CN1756525A - Pseudo body odor composition and perfume composition for inhibiting body odor - Google Patents
Pseudo body odor composition and perfume composition for inhibiting body odor Download PDFInfo
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Abstract
A pseudo body odor composition according to the present invention comprises (A) at least one kind selected from (A-1) hydroxyalkynyl carboxylic acids having 5 to 8 carbon atoms and (A-2) alkenyl carboxylic acids having 5 to 8 carbon atoms and one double bond; (B) at least one kind selected from fatty acids having 2 to 24 carbon atoms; and (C) at least one kind selected from aldehydes having 2 to 13 carbon atoms. A deodorant perfume composition according to the invention includes one kind or more components that are excellent in masking effect and/or a harmonizing effect to an acid odor selected from hydroxyalkynyl carboxylic acids having 5 to 8 carbon atoms and alkenyl carboxylic acids having 5 to 8 carbon atoms and one double bond.
Description
Technical field
The present invention relates to a kind of pseudo body odor compositions of the special odor that approaches true body odor more and had, in more detail, relate to a kind of pseudo body odor compositions, the special odor that said composition approaches body odor more and had, for example owing to the abnormal smells from the patient of human body perspiration and the abnormal smells from the patient of axillary fossa, preferred said composition can be used to estimate the effect of sheltering, being in harmonious proportion or remove stink with perspiration, axillary fossa abnormal smells from the patient etc.; And use this pseudo body odor compositions to estimate the method for sheltering, being in harmonious proportion or remove effects such as stink with perspiration, axillary fossa abnormal smells from the patient.
And then, the present invention relates to be used to suppress the flavor compositions of body odor, in more detail, relate to a kind of flavor compositions that is used to suppress body odor, said composition can shelter effectively and/or be in harmonious proportion because the acidic smell that body odor and stink with perspiration give out, and the method that contains the deodorant compositions of said composition or external treatment compositions and a kind of new inhibition body odor.
Background technology
Owing to feel cleaning, like that particularly recent, it is extremely important that abnormal smells from the patient becomes; Wherein, remove the demand of the abnormal smells from the patient that gives out in the human body, that is to say, the demand of removing body odor is strong especially.The known abnormal smells from the patient that comes out from human body comprises abnormal smells from the patient, oral cavity smell, stink with perspiration, bromhidrosis, foot odor of scalp or hair etc.On the other hand, also be starved of and remove oral cavity smell, feces and because the abnormal smells from the patient of the urine that sulphur compound produces etc., and because the corrupt abnormal smells from the patient that the specific components of the catabolite of organic compound produces.In these abnormal smells from the patients, bromhidrosis it is believed that it is because sweat gland, the secretions of sebaceous gland, exocrine gland, eccrine gland etc. for example, the abnormal smells from the patient that produces through peroxidating or action of microorganisms.For example stink with perspiration, foot flavor etc. comprise the abnormal smells from the patient of bromhidrosis, in interpersonal generation sensation beastly.Therefore, occur various means up to now and removed this abnormal smells from the patient.In view of the situation, be starved of the product that is provided for suppressing or reducing the body odor that comprises bromhidrosis and stink with perspiration to market.
For the method for removing abnormal smells from the patient, known have a whole bag of tricks, for example the formation of the material by suppressing to produce stink suppresses the method that abnormal smells from the patient produces, and suppresses the method for the propagation of the microorganism relevant with the generation stink, the method for sheltering stink substance with particular perfume.In commercially available various products, adopted a kind of abnormal smells from the patient of removing in these methods at least.In order to further specify, for example in a kind of commercially available product, according to its purposes combination a kind of Antiperspirant is arranged, it can suppress a large amount of perspirations, can produce material odorous and perspire, a kind of antibacterial or antibacterial to be suppressing microbial growth, and a kind of screening agent has the component that can give out fragrance etc.In nearly all Antiperspirant, a kind of aluminium compound as astringent is its main component, uses aluminum chloride usually.In addition, use hexachlorophene and various aliquat as antibacterial or antibacterial usually.And, for having the screening agent that discharges aroma constituent, can use various spice, for example at disclosed Japanese patent application (JP-A) No.6-179610, Japanese patent application publication (open) No.2002-505264 of country and Japan Patent office:
Published collection of well-known prior arts (perfume), partI, general of PerfumeThe spice of putting down in writing in (Jan.29,1999) 230-250 page or leaf.
These have abnormal smells from the patient and shelter or during the various product of deodorizing effect when exploitation, need to estimate in advance the material that uses therein or compositions masking effect and the deodorizing effect for abnormal smells from the patient, thereby screen.Up to now, when the masking effect of estimating these abnormal smells from the patients and deodorizing effect, generally use human body to come implementation evaluation.Yet, with regard to being used for the pricer body, there are some problems, except forcing candidate's transition anxiety on one's body, the candidate who is difficult to guarantee to participate in evaluation is reliable, and from human physiology's viewpoint, can not assurance always obtain same phenomenon.And, just when estimating noval chemical compound and compositions, also there is the problem of safety.At this moment, if in evaluation, use to intend the abnormal smells from the patient compositions, need not consider that then the problems referred to above can estimate noval chemical compound and compositions.
Therefore, need to seek be used for to abnormal smells from the patient simply shelter, mediation and deodorization pricer n-body simulation n abnormal smells from the patient, this special abnormal smells from the patient comprises for example stink with perspiration, bromhidrosis etc.So far, after deliberation for example the component of various human scents such as oral cavity smell, scalp abnormal smells from the patient, bromhidrosis, foot odor, stink with perspiration (referring to, for example,
Journal of Chemical Ecology, (USA) 1991,17 (7), the 1469-1492 page or leaf; Head Office of 46
ThTEAC Meeting (sponsoring) by the chemical association of Japan,
46 Th Discussion on Perfume/Terpene and essential oil chemical, contents of lecture, 2002, the 124-126 pages or leaves; Disclosed european patent application No.1,258,531).If can obtain to be in close proximity to the pseudo body odor compositions of real body odor, obviously, as mentioned above, research guarantees to be used for the novel substance of human body or the safety of compositions on the one hand, and is on the other hand, parallel with it, do not consider safety, for bromhidrosis and stink with perspiration, the sheltering of material or compositions, mediation or deodorizing effect are estimated in research how accurately, simple and efficient, and then can screen material and the compositions with this effect effectively.
On the basis of body odor component research, need further to study preparation model abnormal smells from the patient and propose the model abnormal smells from the patient.Among the human body simulation abnormal smells from the patient, for the scalp abnormal smells from the patient, the model abnormal smells from the patient that is used to estimate is disclosed, it contains Squalene, cholesterol and fatty acid as key component (JP-A Nos.2001-220593 and 2001-271088).On the other hand,, mainly studied this component as for stink with perspiration, this component be when sebaceous material and higher fatty acids owing to the oxidized decomposition of inherent antibacterial in the skin produces.But also do not approached the plan abnormal smells from the patient of true stink with perspiration more, particularly, from the special odor of the exocrine gland secretion of for example axillary fossa.Exocrine gland also is present in around eyelid except that axillary fossa, external auditory meatus, the anus, around the nipple etc.
On the other hand, in deodorant products, can mix various flavor compositions; But, those the spice materials that can effectively shelter the axillary fossa abnormal smells from the patient can't be provided at present and have can abundant gratifying feature the spice material.
Summary of the invention
Based on above-mentioned situation, the present inventor adopts gas chromatography, olfactometry, mass spectrography etc. to analyze the component that obtains by solvent extraction from human body axillary fossa part, and finds the odor characteristics of crest sign bromhidrosis at this moment.And, by means, can determine component with mass spectral analysis and chemosynthesis.Up to now, for the component of stink with perspiration, the various carboxylic acids that comprise 3-methyl-2-hexenoic acid and acetic acid have been reported.In addition,, find the ratio of the enantiomer of the 3-hydroxy-3-methyl caproic acid that in the bromhidrosis component, contains and hydroxy carboxylic acid recently, that is to say that the R-body of enantiomer and the ratio of S-body are 1: 3 as present inventor's result of study.The abnormal smells from the patient of chemical compound can show that bromhidrosis is different from the abnormal smells from the patient of those hitherto known 3-methyl-2-hexenoic acids.For the abnormal smells from the patient of hydroxy carboxylic acid, also do not report the method that adopts component odorous to shelter it.
Therefore, the purpose of this invention is to provide a kind of pseudo body odor compositions, said composition approaches real stink with perspiration more, the special odor that goes out from exocrine gland secretion particularly, thereby can correctly estimate stink with perspiration and bromhidrosis shelter, suppress effect etc.; And adopt said composition to estimate for stink with perspiration, the method for the sheltering of bromhidrosis, mediation or deodorizing effect for example.
And another object of the present invention provides a kind of flavor compositions that is used to suppress body odor, and body odor and comprise the stink with perspiration of the bromhidrosis with odour-producing component can effectively be sheltered and/or be in harmonious proportion to said composition.
Also have, another object of the present invention provides a kind of flavor compositions that is used to suppress body odor, and the acidic smell that comes out can effectively be sheltered and/or be in harmonious proportion to said composition from body odor and stink with perspiration.
Also have, another object of the present invention provides a kind of deodorant compositions or external treatment compositions that is useful on the flavor compositions that suppresses body odor that contain, and the acidic smell that comes out can effectively be sheltered and/or be in harmonious proportion to said composition from body odor and stink with perspiration.
In addition, another object of the present invention provides a kind of deodorant compositions or external treatment compositions that is useful on the flavor compositions that suppresses body odor that contain, and stink with perspiration and bromhidrosis can effectively be sheltered and/or be in harmonious proportion to said composition.
In addition, another object of the present invention provides a kind of method that suppresses body odor.
The present inventor is on the bromhidrosis results of analysis, recently developed a kind of pseudo body odor compositions, and many single spice is carried out The selection result with new pseudo body odor compositions, acidic smell can be sheltered and/or be in harmonious proportion to the spice of finding some kind effectively, for example stink with perspiration and bromhidrosis, that is, acidic smell is selected from above-mentioned hydroxyl alkynyl carboxylic acid and the thiazolinyl carboxylic acid with 5 to 8 carbon atoms and two keys with 5 to 8 carbon atoms, thereby realizes the present invention.
That is to say, the present invention relates to according to the following the 1st to the 4th described pseudo body odor compositions and according to following the 5th described be used to estimate shelter, the method for mediation or deodorizing effect.
1. pseudo body odor compositions comprises:
(A) at least a being selected from (A-1) has the hydroxyl alkynyl carboxylic acid of 5 to 8 carbon atoms and the thiazolinyl carboxylic acid that (A-2) has 5 to 8 carbon atoms and two keys; (B) at least a fatty acid that is selected from 2 to 24 carbon atoms; (C) at least a aldehyde that is selected from 2 to 13 carbon atoms.
2. the pseudo body odor compositions of in above-mentioned the 1st, mentioning, wherein component (A) comprising:
(A-1) at least a hydroxyl alkynyl carboxylic acid that is selected from 5 to 8 carbon atoms; With
(A-2) at least a thiazolinyl carboxylic acid that is selected from 5 to 8 carbon atoms and two keys.
3. in the pseudo body odor compositions described in the above-mentioned the 1st or the 2nd, wherein component (A-1) is the raceme and the optically active form of at least a 3-of being selected from hydroxy-3-methyl caproic acid.
4. in the above-mentioned the 1st to the 3rd pseudo body odor compositions described in any one, wherein component (A-2) is the cis-isomer and the transisomer of at least a 3-of being selected from methyl-2-hexenoic acid.
5. one kind is used to estimate the method for sheltering, being in harmonious proportion or remove the stink with perspiration effect, is characterised in that use is in the 1st to the 4th pseudo body odor compositions described in any one.
In addition, the present invention relates to the flavor compositions that is used to suppress body odor, according to the 10th deodorant compositions, according to the 11st external preparation composition with according to the method for the 12nd and the 13rd inhibition body odor according to the following the 6th to the 9th.
6. flavor compositions that is used to suppress body odor, comprise at least a or multiple component of sheltering admirably and/or being in harmonious proportion the acidic smell effect that has, this acidic smell is selected from the hydroxyl alkynyl carboxylic acid with 5 to 8 carbon atoms and has 5 to 8 carbon atoms and the thiazolinyl carboxylic acid of two keys.
7. at the flavor compositions that is used to suppress body odor described in above-mentioned the 6th, wherein acidic smell is 3-hydroxy-3-methyl caproic acid and/or 3-methyl hexenoic acid.
8. the flavor compositions that is used to suppress body odor described in the above-mentioned the 6th or the 7th wherein has the component of sheltering admirably and/or being in harmonious proportion acidic smell, comprising:
(I) at least a or multiple chemical compound or the essential oil of being selected from, its fragrance shelter and be in harmonious proportion all show aspect the acidic smell effect fabulous;
(II) at least a or multiple chemical compound or the essential oil of being selected from, its fragrance is in that to shelter aspect the acidic smell performance fabulous, but in that to be in harmonious proportion aspect the acidic smell performance neutral; With
(III) as required, at least a or multiple chemical compound or the essential oil of being selected from, its fragrance all do not have effect aspect the acidic smell two sheltering and be in harmonious proportion.
9. the flavor compositions that is used to suppress body odor described in above-mentioned the 8th wherein in gross weight, comprises 40% weight or above component (I), comprises 60% weight or above component (I) and (II), comprises the component (III) that is less than 40% weight.
10. the deodorant compositions that comprises the flavor compositions of the above-mentioned the 6th to the 9th inhibition body odor described in any one.
11. comprise the external preparation composition of the flavor compositions of the above-mentioned the 6th to the 9th inhibition body odor described in any one.
12. a method that suppresses body odor is characterized in that, for being selected from the hydroxyl alkynyl carboxylic acid with 5 to 8 carbon atoms and having 5 to 8 carbon atoms and the acidic smell of the thiazolinyl carboxylic acid of two keys, uses following material:
(I) at least a or multiple all have the chemical compound or the essential oil of excellent effect aspect the acidic smell sheltering and be in harmonious proportion;
(II) but at least a or multiple being selected from sheltering fabulously aspect the acidic smell is being in harmonious proportion neutral chemical compound or essential oil aspect the acidic smell; With
(III) as required, at least a or multiple being selected from sheltering and be in harmonious proportion all do not have the chemical compound and the essential oil of effect aspect the acidic smell two.
13. be used to be suppressed at the method for the body odor described in above-mentioned the 12nd, wherein acidic smell is 3-hydroxy-3-methyl caproic acid and/or 3-methyl hexenoic acid.
In addition, according to the flavor compositions that is used to suppress body odor of the present invention can be suitably with at random mix mutually with other flavor compositions according to the object of the invention.Therefore, the present invention's flavor compositions of being used for suppressing body odor can be widely used in various potpourris.
Description of drawings
Fig. 1 is the gas chromatogram of the extract that extracts from the absorbent cotton at wiping axillary fossa position with ether.
Fig. 2 is the example of the synthesis path figure of the R-enantiomer of 3-hydroxy-3-methyl caproic acid and S-enantiomer.
Fig. 3 is the gas chromatogram of qualification result of the methyl ester of the specific components of the more employed extract that extracts from the absorbent cotton at wiping axillary fossa position by ether and synthetic 3-hydroxy-3-methyl caproic acid (R-enantiomer and S-enantiomer).
The specific embodiment
Before the present invention is described in detail in detail, at first explain the analysis of bromhidrosis and the evaluation of component.The identification of the component analysis of bromhidrosis and analytical method and characteristic peak:
After wiping the absorbent cotton at axillary fossa position, thereby make molten concentrating agents preparation extraction sample with the ether extraction.The gas chromatography of employing suction air, mass spectrography etc. are analyzed sample.Fig. 1 shows the gas chromatogram with the extract of the absorbent cotton acquisition at ether extraction wiping axillary fossa position.According to present inventor's analysis, adopt the gas chromatography that sucks air, can find the peak of indicating characteristic abnormal smells from the patient.
In addition, compare from the mass spectral analysis at the peak of indicating characteristic abnormal smells from the patient and the chemical compound that obtains with chemical synthesis process, the component that can be clear that the peak of indicating characteristic abnormal smells from the patient is a 3-hydroxy-3-methyl caproic acid, and in hydroxy carboxylic acid, as the enantiomer ratio of two enantiomers, the ratio of R-body and S-body is 1: 3 (referring to Fig. 3).
In addition, the R-enantiomer of 3-hydroxy-3-methyl caproic acid and S-enantiomer can be synthesized into by path shown in Figure 2.Synthetic method wherein can reference, for example, and JP-A No.10-25265,
J.Org.Chem.(USA), 1983, the 48 the volume, No.22, the 3960-3966 page or leaf and
Tetrahedron Asymmetry(USA), 1996, the 7 volumes, No.7,2023-2028 page or leaf.
Show the 3-hydroxy-3-methyl caproic acid of this discovery, to the odour-producing component of stink with perspiration exhibit flavour feature, and the contrast of the abnormal smells from the patient quality of the known up to now 3-methyl-2-hexenoic acid abnormal smells from the patient that can be used as the odour-producing component of bromhidrosis in the table 1 below.
Table 1
| Quality of flavoring | |
| 3-hydroxy-3-methyl caproic acid (raceme) | The similar bromhidrosis of the abnormal smells from the patient of similar cumin spice is weaker than the S-body |
| (R) 3-hydroxy-3-methyl caproic acid (raceme) | The abnormal smells from the patient of similar cumin spice is weaker than raceme |
| (S) 3-hydroxy-3-methyl caproic acid (raceme) | The abnormal smells from the patient of similar bromhidrosis and similar cumin spice |
| 3-hydroxy-3-methyl caproic acid (raceme) (R)-body/(S)-body=1/3 | The abnormal smells from the patient of similar consumingly bromhidrosis and similar cumin spice |
| Trans-3-methyl-2-hexenoic acid | Acidic smell |
| Cis-3-methyl-2-hexenoic acid | Acidic smell |
| 3-methyl-2-hexenoic acid (transisomer/cis-isomer=1/1) | Than the more intensive acidic smell of cis-isomer |
(1) pseudo body odor compositions
In the present invention, on the basis of The above results, consider and estimate, further carry out the structure again of compositions, thereby obtain to approach more the pseudo body odor compositions of real axillary fossa abnormal smells from the patient.
In pseudo body odor compositions of the present invention, the carboxylic acid of said components (A) is very important for duplicating " the peculiar abnormal smells from the patient of exocrine gland ", and this distinctive abnormal smells from the patient is owing to eccrine secretions in the stink with perspiration produces.A kind of abnormal smells from the patient that " the peculiar abnormal smells from the patient of exocrine gland " expression shows as the root material owing to eccrine secretions, and a kind of body odor that can smell consumingly by nature (stink with perspiration, bromhidrosis).Particularly on crowded train, the peculiar abnormal smells from the patient of this exocrine gland can be consumingly, instantaneously smelt, when a people when a parlor moves to another parlor, can bring sensation beastly to other people.If do not consider the peculiar abnormal smells from the patient of exocrine gland, just can not finish and approach stink with perspiration and the particularly preparation of bromhidrosis abnormal smells from the patient.
The component of pseudo body odor compositions of the present invention (A) comprises at least a hydroxyl alkynyl carboxylic acid with 5 to 8 carbon atoms, and it is as component (A-1), and/or at least a thiazolinyl carboxylic acid with 5 to 8 carbon atoms and two keys, and it is as component (A-2).
Component (A-1) as hydroxyl alkynyl carboxylic acid with 5 to 8 carbon atoms, concrete can be 3-hydroxy-3-methyl valeric acid for example for example, 3-hydroxy-3-methyl caproic acid etc., the raceme and the optically active substance of preferred 3-hydroxy-3-methyl caproic acid, but hydroxyl alkynyl carboxylic acid is not limited to above-mentioned these.In addition, in 3-hydroxyl 3-methylhexanoic acid, the scope that is more preferably as the ratio of the R-body of enantiomer and S-body is from 1.5: 1 to 1: 20, and further preferred range is from about 1: 1 to about 1: 5.In whole compositions, by weight, the scope of the component that is contained (A-1) is about from 0.1 to 50% weight, and preferably approximately 1 to 30% weight is more preferably 5 to 20% weight.
On the other hand, the component (A-2) as the thiazolinyl carboxylic acid with 5 to 8 carbon atoms and two keys specifically is exemplified as 3-methyl-2 penetenoic acid, 3-methyl-2-hexenoic acid, 3-methyl-2-heptenoic acid etc.In addition, the preferred embodiment of thiazolinyl carboxylic acid comprises the cis-isomer and the transisomer of 3-methyl-2-hexenoic acid, preferred example comprises that in the geometric isomer of 3-methyl-2-hexenoic acid, the ratio of cis-isomer and transisomer is from about 1: 1 to about 1: 10.But the thiazolinyl carboxylic acid is not to be defined in above-mentioned these predetermined substances.In whole compositions, by weight, the scope of the component that is contained (A-2) is approximately from 0.1 to 50%, preferably approximately from 1 to 30%, be more preferably from 5 to 20%.
In addition, in the present invention, preferred ingredient (A-1) and component (A-2) are used together.At this moment wait, conjugate as component (A-1) and component (A-2), for instance, the conjugate of 3-hydroxy-3-methyl caproic acid and 3-methyl-2-hexenoic acid, wherein the ratio of the optically active R-enantiomer of 3-hydroxy-3-methyl caproic acid and S-enantiomer is 1: 1 to 1: 3; 3-methyl-the cis-isomer of 2-hexenoic acid and the ratio of transisomer are 1: 1 to 1: 10, are more preferably 1: 1 to 1: 3.With regard to component (A-1) and component (A-2) are used together, be 1: 1 to 10: 1 (A-1) with (A-2) ratio, preferred especially 1: 1 to 3: 1.
In the present invention, as the fatty acid that shown in component (B), has 2 to 24 carbon atoms, can exemplify out straight chain or side chain, saturated or undersaturated fatty acid, can contain hydroxyl, such as acetic acid, propanoic acid, butanoic acid, isopropylformic acid., positive valeric acid, isovaleric acid, caproic acid, enanthic acid, sad, n-nonanoic acid, capric acid, dodecoic acid, tridecanoic acid, myristic acid, pentadecanoic acid, Palmic acid, palmitoleic acid, heptadecanoic acid, stearic acid, oleic acid, linoleic acid, hydroxyacetic acid, lactic acid, 3-hydroxybutyric acid etc.Wherein, any one in acetic acid and the propanoic acid all is the important component of duplicating the acidic smell of real stink with perspiration and bromhidrosis, and adds fashionablely when another fatty acid, can prepare preferred stink with perspiration and bromhidrosis.Here, as other fatty acid, for instance, the fatty acid that preferably has 4 to 18 carbon atoms, for example butanoic acid, isopropylformic acid., valeric acid, isovaleric acid, caproic acid, enanthic acid, sad, n-nonanoic acid, capric acid, dodecoic acid, tridecanoic acid, myristic acid, pentadecanoic acid, Palmic acid, palmitoleic acid, heptadecanoic acid, stearic acid, oleic acid, linoleic acid etc.The fatty acid that wherein has 8 to 18 carbon atoms is important in duplicating the oils and fats abnormal smells from the patient of the stink with perspiration that comprises bromhidrosis.
The mixed proportion of the fatty acid with 2 to 24 carbon atoms in the component (B) is, for acetic acid or propanoic acid, and in the weight of total composition, preferably approximately from 0.001 to 50%, be more preferably approximately from 0.1 to 20% and further preferably from 5 to 15%; For the fatty acid with 4 to 24 carbon atoms, in the weight of total composition, mixed proportion is preferably approximately from 0.001 to 80%, is more preferably at approximately from 0.1 to 70% and further preferably from 1 to 50%.
In the present invention, as the aldehyde that shown in component (C), has 2 to 13 carbon atoms, for instance, straight chain or side chain, saturated or undersaturated aldehyde are arranged, such as acetaldehyde, propionic aldehyde, butyraldehyde, valeral, isovaleral, hexanal, enanthaldehyde, octanal, aldehyde C-9, capraldehyde, undecyl aldehyde, dodecyl aldehyde, tridecyl aldehyde, myristyl aldehyde, cetyl aldehyde, 3-hexenoic aldehyde, 4-heptenal, 2-nonenyl aldehyde, 4-decenal, undecylene aldehyde, 2,6-nonadienal, decadienal, methyl octyl acetaldehyde, methyl nonyl acetaldehyde etc.Wherein, the saturated aldehyde with 6 to 12 carbon atoms is important in duplicating the greasy abnormal smells from the patient of stink with perspiration and bromhidrosis.The mixed proportion of the aldehyde with 2 to 13 carbon atoms in the component (C) is, in the weight of total composition, and preferably approximately from 0.001 to 50%, be more preferably approximately from 0.01 to 10% and further preferably from 0.1 to 5%.
In order to adjust for example accurate mass and the concentration of the body odor of stink with perspiration and bromhidrosis, except component (A) to (C), in pseudo body odor compositions of the present invention, can also sneak into Squalene, squalane, cholesterol or derivatives thereof, aminoacid, glyceride, have 2 to 24 carbon atoms straight chain or branched chain fatty acid, contain the volatility nitrogen compound, contain the chemical compound of volatile sulfur etc.With respect to the weight portion of component (A) to (C), the amount that can add is 0.00001 to 10000 weight portion.
Except component (A) arrives (C), in these mixing cpds, as cholesterol derivative, for instance, can be to have the cholesterol ester straight chain of 11 to 16 carbon atoms or side chain, saturated or unsaturated fatty acid, such as, hendecanoic acid cholesterol ester, dodecylic acid cholesterol ester, tridecanoic acid cholesterol ester, tetradecylic acid cholesterol ester, pentadecanoic acid cholesterol ester, cholesteryl palmitate ester, palmitoleic acid cholesterol ester etc.In addition, as aminoacid, for instance, aminoacid that can be proline, the proline, leucine, phenylalanine, serine, threonine, citrulline (citrulline), valine, lysine, arginine, the protein that comprise peptide is decomposed by protease and form etc.As glyceride, illustrate, can be to have the glyceride straight chain of 2 to 24 carbon atoms or side chain, saturated or unsaturated fatty acid, such as capric acid, hendecanoic acid, dodecylic acid, tridecanoic acid, tetradecylic acid, myristic acid, pentadecanoic acid, Palmic acid, palmitoleic acid etc.This glyceride comprises all single, double and triple fatty glycerides.And triglyceride, particularly straight chain or side chain, saturated or undersaturated triglyceride with fatty acid of 16 carbon atoms is preferred such as Palmic acid triglyceride, palmitoleic acid triglyceride etc.As fatty acid ester, can be lauric acid hexyl ester, lauric acid heptyl ester, lauric acid octyl group ester, lauric acid nonyl ester, Palmic acid hexyl ester, Palmic acid heptyl ester, Palmic acid octyl group ester, Palmic acid nonyl ester, palmitoleic acid hexyl ester etc. for instance.In addition, as volatile nitrogen-containing compound and volatile sulfur-containing compound, can be ammonia, trimethylamine, tri-n-butylamine, hydrogen sulfide, methanthiol etc. for instance.
And, in order to adjust concentration, solvent (solubilizing agent) can be mixed to join in the compositions according to pseudo body odor compositions of the present invention, it is important duplicating aspect the intensity of true body odor.In the chemical constituent of antiperspirant, as everyone knows, the main component outside dewatering is that lactic acid is (referring to, Boukin Boubai for example, 1985, the 13rd volume, No.8, the 363rd to 372 page), and because lactic acid is for not influence of stink with perspiration (bromhidrosis), so it can be used as solubilizing agent and uses, among the present invention with it preferably as the solubilizing agent of pseudo body odor compositions, be used to duplicate the component of true stink with perspiration and bromhidrosis.In addition, owing to have identical characteristic, also can use the fatty acid that contains 2 to 4 carbon atoms and a hydroxyl with lactic acid, such as hydroxyacetic acid, 3-hydroxybutyric acid, and preferably these materials as the solubilizing agent of pseudo body odor compositions of the present invention.
As solubilizing agent, except that the above solubilizing agent, can use any abnormal smells from the patient not have the material of influence, but be not limited to above-mentioned material for for example stink with perspiration and bromhidrosis.As the solubilizing agent except that the above solubilizing agent, for instance as: preferred alcohol, 3-methoxyl group-3-methyl butanol, propylene glycol, dipropylene glycol, diethyl phthalate, triethyl citrate, benzyl benzoate, liquid paraffin etc.Among these solubilizing agents, when considering viscosity and solubilization, from the viewpoint that said composition is used to estimate, preferred alcohol, 3-methoxyl group-3-methyl butanol, dipropylene glycol, diethyl phthalate, triethyl citrate, benzyl benzoate etc.; Set out preferred dipropylene glycol, diethyl phthalate, triethyl citrate and benzyl benzoate if never produce the viewpoint of abnormal smells from the patient.With respect to the weight portion of component (A) to (C) total amount, preferably the amount of the solubilizing agent that can add is 0.001 to 10000 weight portion.
So prepared pseudo body odor compositions approaches real stink with perspiration, bromhidrosis etc.Therefore, adopt said composition, can be accurately and estimate screening ability effectively, be in harmonious proportion effect or deodorizing effect for stink with perspiration, bromhidrosis etc.The result can screen the material that has screening ability, mediation effect or deodorizing effect for the abnormal smells from the patient of stink with perspiration, bromhidrosis etc. effectively.Therefore, odor masking agent, deodorizer and abnormal smells from the patient inhibitor be can be applied to develop according to pseudo body odor compositions of the present invention and assessment method, and the various body deodorants of screening agent, deodorizer or abnormal smells from the patient inhibitor, various human body detergent and various laundry detergent compositions sneaked into.
When using the pseudo body odor compositions that is used to estimate of the present invention, can easily carry out, particularly for the screening ability of the stink with perspiration that causes, bromhidrosis etc., the evaluation of effect or deodorizing effect of being in harmonious proportion because human body is perspired for body odor.For example, sample is joined the pseudo body odor compositions that is used for estimating of the present invention, perhaps sample is contacted with compositions of the present invention, then the abnormal smells from the patient of its abnormal smells from the patient by olfactory sensation and body odor compositions of the present invention compared.As special method, can use the cup method.In the evaluation of abnormal smells from the patient, preferably undertaken by 1 to 20 specialist crew and rank and file.Also have, preferably the evaluation of carrying out is divided into 2 to 7 and estimates ranks, is more preferably to be divided into 3 to 5 and to estimate ranks and undertaken by the member of expert group.
Use the pseudo body odor compositions that is used to estimate of the present invention, can easily carry out for body odor particularly the evaluation of the sheltering of because human body the is perspired stink with perspiration cause, bromhidrosis etc., mediation or deodorizing effect, can be correctly and filter out material effectively with these effects.In addition, study its safety fully on the one hand, on the other hand, follow the research of safety to carry out functional evaluation.Therefore, can realize effective Products Development.
(2) deodorizer flavor compositions
Acidic smell can be sheltered and/or be in harmonious proportion to the flavor compositions of inhibition body odor of the present invention effectively, this acidic smell is from having 5 to 8 carbon atom hydroxyl alkynyl carboxylic acids, with thiazolinyl carboxylic acid with 5 to 8 carbon atoms and two keys, this acidic smell is discharged by body odor, this stink with perspiration (hereinafter, be sometimes referred to as " such as the acidic smell of stink with perspiration and bromhidrosis ") typically comprise, as component, (I) has chemical compound or the essential oil (being sometimes referred to as hereinafter, " sheltering component ") of sheltering admirably and being in harmonious proportion effect for acidic smell such as stink with perspiration and bromhidrosis; (II) its fragrance has excellent effect aspect the masking effect of the acidic smell of stink with perspiration and bromhidrosis, but is being in harmonious proportion chemical compound or the essential oil (being sometimes referred to as hereinafter, " mediation neutral component ") that has neutral effect aspect the effect; (III) as required, its fragrance does not have chemical compound or the essential oil (being sometimes referred to as hereinafter, " surplus component ") of sheltering or being in harmonious proportion effect for acidic smell.Hereinafter, detailed description comprises the chemical compound and the essential oil of component separately.Yet the chemical compound of illustrational separately following component (I) to (III) and essential oil only are as an example; That is to say the above component of the present invention (I), (II) and (III) be not limited to following example.
(I) shelter component
Sheltering component and be the masking effect of the acidic smell of for example stink with perspiration and bromhidrosis and the component that the effect that is in harmonious proportion all has fabulous effect, illustrate, for example can be chemical compound and the essential oil that is selected from following group (I-1) to (I-7).
(I-1) alcohol
Cis 3-hexenol, phenethanol, ethanol, citronellol, 2-ethyl-4-(2,2,3-trimethyl-3-cyclopentenes-1--yl)-2-butylene-1-alcohol (Levosandol: by TakasagoInternational Corp. make), 2-methyl-4-(2,2,3-trimethyl-3-cyclopentenes-1--yl)-2-butylene-1-alcohol (Sandalmysore Core: make), geraniol and Borneolum Syntheticum by Kao Corp..
(I-2) ester and lactone
Cis-3-hexenyl acetate, Styrylallyl acetate, pi-allyl amyl group oxyacetate, phenethyl acetate, benzyl acetate, cis-3-hexenyl salicylate, 2-tert-butylcyclohexyl acetate (Verdox: make) by Kao Corp., jessamona (Hedion: by Firminich, Inc. makes), essence of Niobe, methyl phenylacetate, ethyl acetoacetate, allyl hexanoate, ethyl-2-methyl butyrate, ethyl-2-methyl valerate, pi-allyl cyclohexyl hydroxacetic acid ester (Cyclogalbanate: make) by Dragoco, the methylamino benzoate, γ-undecalactone, nonyl lactone, γ-decalactone and coumarin.
(I-3) aldehyde and acetal
Dimethyl tetrahydro benzaldehyde (Tripral: make), ethyl vanillin, citronellal, hexanal, octanal, benzaldehyde, 2 by IFF, 6-dimethyl-5-heptenal (Melonal: make), citral, isocyclocitral (Isocyclocitral: make), 4-methoxybenzaldehyde, citral diethyl acetal (Citrathal: make), Acetoaldehydephenylethylpropyl acetal and phenyl acetaldehyde dimethylacetal by Quest by IFF by Givaudan.
(I-4) ketone
Damascenone, methyl ionone soap, β-damascone, Camphora, methylene tetramethyl heptanone (Koavone: make), 1-(5,5-dimethyl cyclohexene-1--yl)-4-amylene-1-ketone (α-Dynascone: make), menthone and 1-carvone by Firminich by IFF.
(I-5) ether
Decahydro-3 α, 6,6,9 α-tetramethyl ten dihydro naphthols [2,1-b] furan (Ambroxan: by Henkel make), 2-butyl-4,6-dimethyl-dihydropyran (Vigorose: make), p-Tolyl methyl ether, phenyl acetaldehyde, Flos Rosae Rugosae oxide and β-Nai Jiami by Quest.
(I-6) nitrogen-containing compound
Isobutylquinoline., geranonitrile, 3,7-Dimethyl-6-octenenitrile and hydroxycitronellal methyl 2-aminobenzoate (Hydoroxycitronellylidene methyl anthranilate, anrantiol: make) by TakasagoInternational Corp..
(I-7) essential oil
Fructus Citri Limoniae oil, lime oil, orange oil, oil of rosemary, ylang ylang oil, mandarin oil, eucalyptus oil, lavandin oil, Oleum Pelargonii Graveolentis, chamomile oil, Cardamom oil, citronella oil, elemi oil, Oleum Cinnamomi, petitgrain oil, Flos Tagetis Erectae oil, mugwort oil, kahikatea Oleum sesami, oleum menthae piperitae, sage oil, Flos Caryophylli oil, Oleum Rosae Rugosae, basil oil and Oleum Menthae Rotundifoliae.
Among these shelter component, as for stink with perspiration particularly the component of bromhidrosis with fabulous masking effect be, for instance;
(I-1) alcohol, be selected from cis-3-hexenol, phenethanol, citronellol, 2-ethyl-4-(2,2,3-trimethyl-3-cyclopentenes-1--yl)-2-butylene-1-alcohol (Levosandol: by Takasago International Corp. make), 2-methyl-4-(2,2,3-trimethyl-3-cyclopentenes-1--yl)-2-butylene-1-alcohol (Sandalmysore Core: make), geraniol and Borneolum Syntheticum by Kao Corp..
(I-2) ester and lactone are selected from cis-3-hexenyl acetate, Styrylallyl acetate, pi-allyl amyl group oxyacetate, phenethyl acetate, benzyl acetate, cis-3-hexenyl salicylate, 2-tert-butylcyclohexyl acetate (Verdox: made by Kao Corp.), jessamona (Hedion: made by Firminich Inc.), γ-undecalactone and coumarin.
(I-3) one or more aldehyde are selected from dimethyl tetrahydro benzaldehyde (Tripral: made by IFF) and ethyl vanillin.
(I-4) ketone is selected from damascenone, methyl ionone and β-damascone.
(I-5) ether is decahydro-3 α, 6,6, and 9 α-tetramethyl ten dihydro naphthols [2,1-b] furan (Ambroxan: make) by Henkel.And,
(I-7) essential oil is selected from Fructus Citri Limoniae oil, lime oil, orange oil, oil of rosemary, ylang ylang oil, mandarin oil, eucalyptus oil, lavandin oil and Oleum Pelargonii Graveolentis.
Group in (A) chemical compound or in the essential oil each can be sneaked into individually or both or more persons in conjunction with sneaking into, be used as the component (I) (sheltering component) that is used for suppressing the compositions of body odor of the present invention.Shelter component at these of the flavor compositions that is used for suppressing body odor of the present invention,,, suitably select the mixed volume of each component for the masking effect of stink with perspiration, body odor etc. and other blending ingredients of further adding according to selected specific components; That is to say that it is not to be defined in specific these.In the present invention, sneak into and shelter component, this component is for stink with perspiration, and particularly bromhidrosis shows fabulous masking effect.Therefore, can provide the compositions that is used to suppress body odor of the present invention, said composition can be used to comprise deodorizer, external preparation of spice etc.
(II) mediation neutral component
As being in harmonious proportion neutral component, the fragrance of its chemical compound or essential oil has excellent effect aspect the masking effect of the acidic smell of for example stink with perspiration and bromhidrosis, but has neutral effect aspect the mediation effect, for instance, for example can be, one or more be selected from chemical compound or essential oil that following (II-1) to (II-7) organizes separately.
(II-1) alcohol
Ethyl linalool, 2,6-Dimethyl-2-octanol, 4-methyl-3-decene-5-alcohol (Undecavertol: make), 9-decen-1-ol, right-tert-butyl group Hexalin and dimethyl octanol by Givaudan.
(II-2) ester
Allyl cyclohexyl propionate, terpinyl acetate, Tricyclodecenyl acetate, geraniol acetate, amyl salicylate, phenethyl phenylacetate, ethyl 3-methyl-3-phenyl glycidyl acid esters, ethyl-2,2,6-trimethyl-cyclohexane carboxylate (Thesaron: make), trichloromethyl phenyl methyl acetate (Flos Rosae Rugosae phenyl ketone) and anisyl acetate by Takasago International corp..
(II-3) aldehyde
Heliotropine, right-tert-butyl group-the Alpha-Methyl benzenpropanal (Lilial: make) by Givaudan, 4 (3)-(4-hydroxy-4-methyl phenyl)-3-cyclohexene-1-carboxyl aldehyde (Kovanol: make) by TakasagoInternational Corp., hydroxycitronellal, Alpha-Methyl-3,4-methylene dihydroxyphenyl propionic aldehyde (Helional: make) by IFF, cinnamic aldehyde, the 2-methyl hendecanal, 4, the tricyclo decene butyraldehyde, to ethyl-α, alpha-alpha-dimethyl phenyl propyl aldehyde (Floralozone: make) and 4-(4-methyl-3-pentenyl)-3-cyclohexene-1-carbonyl acetaldehyde (Myrac aldehyde: make) by IFF by IFF.
(II-4) ketone or ketal
α-damascone, δ-damascone, 6-acetyl group-1; 1; 2; 4; 4; 7-hexamethyl tetrahydronaphthalene (Tonalid: make), allyl ionone, the 4-tert-butyl group-2 by PFW, 6-dimethyl acetophenone, 5-ring hexadecene-1-ketone (Ambretone: make) by TakasagoInternational Corp..3-methyl-2-amyl group-2-cyclopentenes-1-ketone (dihydro jasmone) and 2,4,6-trimethyl-4-phenyl-1,3-dioxane (Tloropal: by Harman﹠amp; Rimmer makes).
(II-5) ether
Acetaminol, diphenyl ether and 4-methyl-2 pentanone-(2-methyl-propyl) tetrahydro-2H-4-Pai Lannuo oil (dihydro Flos Rosae Rugosae oxide).
(II-6) nitrogen-containing compound
Tridecylen-2-nitrile.
(II-7) essential oil
Cedar oil, juniper berry oil, Folium Caryophylli oil, Oleum thymi vulgaris and Semen Myristicae oil.
In these are in harmonious proportion neutral component, as for stink with perspiration particularly bromhidrosis have the component of fabulous masking effect, for instance, can be
(II-1) Ethyl linalool in the alcohol;
(II-2) ester is selected from allyl cyclohexyl propionate, terpinyl acetate, Tricyclodecenyl acetate, geraniol acetate and amyl salicylate;
(II-3) aldehyde, be selected from heliotropine, right-tert-butyl group-the Alpha-Methyl benzenpropanal (Lilial: make), 4 (3)-(4-hydroxy-4-methyl phenyl)-3-cyclohexene-1-carboxyl aldehyde (Kovanol: make), hydroxycitronellal, Alpha-Methyl-3,4-methylene dihydroxyphenyl propionic aldehyde (Helional: make) by IFF by TakasagoInternational Corp. by Givaudan;
(II-4) ketone and ketal are selected from α-damascone, δ-damascone, 6-acetyl group-1,1,2,4,4,7-hexamethyl tetrahydronaphthalene (Tonalid: made by PFW);
(II-5) ether is acetaminol; With
(II-7) essential oil is Cedar oil.
Chemical compound in the II group or each in the essential oil can be sneaked into individually or both or more persons in conjunction with sneaking into, be used as the component (II) (mediation neutral component) that is used for suppressing the compositions of body odor of the present invention.Shelter component at these of the flavor compositions that is used for suppressing body odor of the present invention,,, suitably select the mixed volume of each component for the masking effect of stink with perspiration, bromhidrosis etc. and other blending ingredients of further adding according to selected specific components; That is to say that it is not to be defined in specific these.In the present invention, sneak into the mediation neutral component, this component is for stink with perspiration, and particularly bromhidrosis shows fabulous masking effect.Therefore, can provide the compositions that is used to suppress body odor of the present invention, said composition can be used to comprise deodorizer, external preparation of spice etc.
(III) surplus component
As the surplus component, this component does not have chemical compound or the essential oil sheltering or be in harmonious proportion effect by the acidic smell for for example stink with perspiration or bromhidrosis and forms, for instance, can be chemical compound or the essential oil that for example is selected from following (III-1) to (III-6) each group.These surplus components have the effect of mediation potpourri fragrance.
(III-1) pure and mild phenol
Dihydro base myrcenol, Santalex (Santalex: make) by Takasago International Corp., the 3,5-dimethylphenyl propanol, the 2-phenylpropanol, 2,2-dimethyl-3-(3-aminomethyl phenyl) propanol, the 1-menthol, cis p-isopropyl hexahydrobenzyl alcohol (Mayol: make) by Firmenich, α, the alpha-alpha-dimethyl phenethanol, 1-(2-tert-butyl group cyclohexyloxy) butane-2-alcohol (Ambercore: make) by Kao Corp., 1-(2,2, the 6-trimethylcyclohexyl)-3-hexanol (Ambestole: make) and thymol by Takasago International Corp..
(III-2) ester
To a tert-butylcyclohexyl acetate (Vertenex: make) by IFF, ethyl (2-methyl [1,3] dioxolanes-2--yl) acetate (Fraistone: make) by IFF, linalyl acetate, Tricyclodecenyl acetate (Cyclaprop: make) by IFF, geranyl acetate, benzyl salicylate, the hexyl salicylate, ethylene Brazil acid esters (MUSK T: make) by Takasago International Corp., Veramoss (Evemyl: make) by Givaudan, 3-amyl group THP trtrahydropyranyl acetate (Jasmal: make) by IFF, the phenylo salicylic acid ethyl ester, ethyl 2-tert-butylcyclohexyl carboxylate (Floramat: make) by Henkel, 10-oxa--16-hexadecanolide (Oxalide: make) by Takasago International Corp., ethyl tricyclo [5.2.1.O
2,6] decane-2--yl carboxylate (Fruitate: by Kao Corp. make), dimethyl benzyl methylene diacetate ester and Cedryl acetate..
(III-3) aldehyde
Lauryl aldehyde, 2-methyl-3-(4-isopropyl phenyl) propionic aldehyde (cyclamen aldehyde), jasmonal H, cumal, 2,6,10-trimethyl-9-undecylene aldehyde, 1-methyl-4-(4-methyl-3-pentenyl)-3-cyclohexene carboxyl aldehyde (Homomyracaldehyde: make), aldehyde C-9, capraldehyde and 3-laurylene aldehyde by IFF.
(III-4) ketone
β-ionone, Acetyl-.alpha.-cedrene (Woodyflor: make), 7-acetyl group-1 by Takasago International Corp.; 2; 3,4,5; 6; 7,8-octahydro-1,1; 6,7-tetramethyl naphthalene (Iso E Super:IFF manufacturing), 4-(4-hydroxyphenyl)-2-butanone (frambinone), 1-Naphthylethanone and cis-jasmone.
(III-5) ether
Hexamethyl six hydrogen rings penta .alpha.-5:6-benzopyran (Glaxolide: make) and first cedroxyde by IFF.
(III-6) nitrogen-containing compound
Indole.
In the surplus component, as to stink with perspiration particularly bromhidrosis have the chemical compound or the essential oil of fabulous mediation fragrance effect, for instance; Can be
(III-1) alcohol is selected from dihydro base myrcenol and Santalex (Santalex: made by TakasagoInternational Corp.);
(III-2) ester is selected from right-tert-butylcyclohexyl acetate (Vertenex: made by IFF), ethyl (2-methyl [1,3] dioxolanes-2--yl) acetate (Fraistone: made by IFF), linalyl acetate, Tricyclodecenyl acetate (Cyclaprop: made by IFF), geranyl acetate, benzyl salicylate, hexyl salicylate, ethylene Brazil acid esters (MUSK T: made by Takasago InternationalCorp.), Veramoss (Evernyl: made by Givaudan) and Cedryl acetate.;
(III-3) aldehyde lauryl aldehyde, 2-methyl-3-(4-isopropyl phenyl) propionic aldehyde (cyclamen aldehyde) and jasmonal H;
(III-4) ketone is selected from β-ionone, Acetyl-.alpha.-cedrene (Woodyflor: made by TakasagoInternational Corp.), 7-acetyl group-1,2,3,4,5,6,7,8-octahydro-1,1,6,7-tetramethyl naphthalene (Iso E Super:IFF manufacturing), 4-(4-hydroxyphenyl)-2-butanone (frambinone);
(III-5) ether is selected from hexamethyl six hydrogen rings penta .alpha.-5:6-benzopyran (Glaxolide: made by IFF).
Group in (III) chemical compound or in the essential oil each can be sneaked into individually or both or more persons in conjunction with sneaking into, be used as the component (III) (surplus component) that is used for suppressing the compositions of body odor of the present invention.In these surplus components that are used for suppressing the body odor compositions of the present invention,, suitably select the mixed volume of each component according to selected specific components, for the masking effect of stink with perspiration, body odor etc. with other blending ingredients that further add; That is to say that it is not to be defined in specific these.In the present invention, by sneaking into the surplus component, show that particularly bromhidrosis has fabulous masking effect for stink with perspiration.Therefore, can provide the compositions that is used to suppress body odor of the present invention, said composition can be used to comprise deodorizer, external preparation of spice etc.
As mentioned above, any one mixed volume is according to selected specific components, assigns to suitably select for other combined group of the masking effect of stink with perspiration, bromhidrosis etc. and further interpolation in component (I), component (II) and the component (III); That is to say that it is not to be defined in specific these.But for its mixed volume, to the total weight of (III), the consumption of component (I) is about 40 to 95% usually, is more preferably 50 to 85% with component (I).In addition, the total amount of the perfume base mixture of component (I) to (III) is generally 60% weight or more, preferred 60 to 100% weight.And the weight of component (III) is less than 50% weight, preferred 0 to 40% weight.Its reason is during less than 60% weight, can not obtain the masking effect of sufficient acid-resisting abnormal smells from the patient to the total amount of the perfume base mixture of (II) usually when component (I).
In the present invention, the following selection of carrying out said components (I), component (II) and component (III).That is to say that an above-mentioned pseudo body odor compositions and target aroma constituent of mentioning mixes, and at room temperature places 30 minutes.By four expert group members estimate for acidic smell shelter and be in harmonious proportion effect thereafter.By adopting the pseudo body odor compositions of exploitation recently, can estimate effectively in the present invention.Specific assessment method, evaluation criterion and evaluation result have been explained in the EXPERIMENTAL EXAMPLE 1 that is described below.
Component (I), (II) and selection (III): as described below, put together for the masking effect of acidic smell and the Evaluation on effect result that is in harmonious proportion and comprehensively to estimate, thereby select component (I), (II) and (III).
Component (I): the sheltering to count and be shown as 2 or more of chemical compound or essential oil in following EXPERIMENTAL EXAMPLE 1, wherein the degree of sheltering for lilestralis (lilial) is set to 1 point, is set to 1 point at the harmonic point that is in harmonious proportion in estimating.
Component (II): shelter sheltering to count and being shown as 1 or more of chemical compound in the evaluation or essential oil above-mentioned, wherein the degree of sheltering for lilestralis (lilial) is set to 1 point, and the harmonic point that is in harmonious proportion in estimating is set to 0 point.
Component (III): shelter sheltering to count and being shown as 2 or more less of chemical compound in the evaluation or essential oil above-mentioned, wherein the degree of sheltering for lilestralis (lilial) is set to 1 point, and the harmonic point that is in harmonious proportion in estimating is set to-1 point.
At the flavor compositions that is used for suppressing body odor of the present invention, except that the above aroma constituent, the perfume base of record can join in the compositions to a certain extent in " synthetic perfume; chemistry and product information, 1996/3/6, Kagaku Kogyo Nippousha " etc., and can not destroy purpose effect of the present invention, that is to say, in certain quality and quantity scope, it can eliminate the irritating sensation of following acidic smell.Except that the above, can sneak into solvent, fixative etc.
The flavor compositions that the present invention is used for suppressing body odor has fabulous screening ability and/or is in harmonious proportion effect the acidic smell of body odor, in the time of in for example adding deodorant compositions or external preparation to, can effectively suppress because the body odor acidic smell that produces of bromhidrosis particularly.
(3) deodorant compositions and external preparation composition
The flavor compositions that is used for suppressing body odor of the present invention can be mixed to join for example deodorant compositions or external preparation composition, to remove because the offending sensation that the acidic smell of generations such as perspiration brings the people.For deodorant compositions or external preparation composition, it can be joined the flavor compositions that is used for suppressing body odor, known additives etc. can be added into wherein in the scope of not destroying purpose effect of the present invention, that is to say, it can eliminate the irritating sensation of following acidic smell in certain quality and quantity scope.As additive, be used to suppress to give an example the flavor compositions of body odor except of the present invention, for example: antioxidant, antibacterial, UV absorbent, wetting agent, and drug component, such as antiinflammatory, brightening agent, astringent, cryogen and medical herbs extract.
As antioxidant, can be for instance, for example: such as the carotenoid of alpha-carotene, beta-carotene, gamma carotene, lycopene (lycopiene), kryptoxanthin, cryptoxanthin, isozeaxanthin, rhodoxanthin, capsanthin, crocetin etc.; Such as 2,5-dimethyl furan, 2-methylfuran, 2,5-biphenyl furan, 1, the furan of 3-diphenyl isobenzofuran etc.; Vitamin E such as alpha-tocopherol, betatocopherol, Gamma-Tocopherol, Delta-Tocopherol etc.; Aminoacid such as alanine of histidine, the acid of color atmosphere, methionine, alanine, Arrcostab etc.; 1, the ester of 4-silicon first cyclo-octene (diadicyclooctane), dibenzylatiooluene (BHT), doubly acid, ascorbic acid, tannic acid, flavonoid etc.Yet antioxidant is not limited to these.Every kind of antioxidant can go to make usually in accordance with known methods, but also can use the commercially available prod.
In addition, the extract with natural drug of antioxidation also can be used as above-mentioned antioxidant and uses.Particularly, the extract of natural drug can be, such as Radix Scutellariae extract, Herba Artemisiae Scopariae extract, gambir extract, Salvia japonica Thunb. extract, tea extract, rosemary extract, Fructus Foeniculi extract, Herba thymi vulgaris extract, Semen Myristicae extract, Fructus Piperis extract, Rhizoma Curcumae Longae extract, defend sub blue immersion, Fructus Capsici extract, the heart of a lotus seed and belong to extract, Radix Bupleuri base extract, Fructus Chaenomelis extract, Lignum Sappan extract, Ku Leen (culen) extract, fine jade lattice granny rag (Jungrahab, Baeckea frtescens L.) extract etc.But the extract of natural drug be not limited to above-mentioned these.
When these antioxidants are mixed to join in deodorant compositions, the external preparation composition etc., its blended amount is roughly 0.0001% weight or above and 10.0% weight or following of composition weight, preferably roughly 0.01% weight or above and 1.0% weight or following.
As antibacterial, can be for instance for example (halocarbane), chlorhexidine hydrochloride (chlorohexydinehydrochloride) in the trichlorocarbanilide, benzalkonium chloride, benzethonium chloride, hello kappa, dihydrofarnesol (referring to for example: JP-A No.08-245979) etc.When these antibacterial are joined when being mixed with the deodorant compositions that is used for suppressing the flavor compositions of body odor of the present invention, external preparation composition etc. by mixed, the amount of its additive is roughly 0.0001% weight or above and 10.0% weight or following of composition weight, preferably roughly 0.005% measures or above and 5.0% weight or following.
Known dihydrofarnesol is as " antibiotic spice ", and it combines the function of antibacterial and spice.But other spice except dihydrofarnesol also can be mixed to join in deodorant compositions of the present invention or the external preparation composition, so that shelter or be in harmonious proportion the acidic smell that may discharge.
For example,, can mix adding if deodorant compositions of the present invention and external preparation composition are used as solvent compositions: p-aminophenyl acidic group UV absorbent, such as para-aminobenzoic acid etc.; O-amino benzoyl acidic group UV absorbent is such as methylamino benzoate etc.; The salicyl UV absorbent is such as octyl group Salicylate, phenyl salicytate, high menthyl Salicylate etc.; The cinnamate group UV absorbent, such as isopropyl p-methoxycinnamic acid salt, octyl group p-methoxycinnamic acid salt, 2-ethylhexyl-p-methoxycinnamic acid salt, glyceryl list ethyl hexanoyl-di-p-methoxy cinnamate, (4-(trimethicone) methyl silicane base-3-methyl butyl)-3,4,5-trimethoxy cinnamic acid salt etc.; Benzophenone base UV absorbent, such as 2,4-dihydroxy benaophenonel, 2-hydroxyl-4 methoxy benzophenone, 2-hydroxyl-methoxy benzophenone-5 sulfonic acid, 2-hydroxyl-4-methoxy benzophenone-5-sodium sulfonate etc.; And UV absorbent, such as urocanic acid, ethyl urocanic acid salt, 2-phenyl 5 methylbenzoxazoles, 2-(2 '-hydroxyl-5 ' aminomethyl phenyl) benzotriazole, 4-tertiary butyl-4 '-methoxyl group DBM etc.
In addition, wetting agent, such as Polyethylene Glycol, propylene glycol, dipropylene glycol, 1,3-butanediol, hexanediol, glycerol, diglycerol, xylitol, maltose alcohol, maltose, mannite, starch syrup, glucose, fructose, lactose, sodium chondroitin sulfate, hyaluronate sodium, adenylic acid sodium, sodium lactate, bile salt, 2-pyrrolidone-5-carboxylic acid, glycosamine, cyclodextrin etc. also can be mixed to join in deodorant compositions of the present invention or the external preparation composition.
And drug component also can be mixed to join in deodorant compositions of the present invention or the external preparation composition.Drug component except having above-mentioned antioxidant advantage, also has other medical applications.Drug component can be, such as vitamin, such as inositol, pyridoxine hydrochloride, nicotinic acid benzyl, nicotiamide, vitamin D2 (erugocalciferol), biotin etc.; Hormone is such as estradiol, ethinyl estradiol etc.; Anti-inflammatory agent is such as allantoin, azulenes, enoxolone etc.; Skin whitener is such as arbutin etc.; Astringency is such as zinc oxide, tannic acid etc.; Coolant is such as left-handed menthol, Camphora etc.; And sulfur, lysozyme chloride etc.In addition, other medical herbs extracts except the medical herbs extract that uses as above-mentioned antioxidant also can mixedly add.
Can be mixed to join other components in deodorant compositions of the present invention and the external preparation composition be not limited to above-mentioned these.In addition, according to its purpose, any one in the above-mentioned illustrational medicine active component can join separately in the external preparation composition, also can join in the external preparation composition with the form of two kinds or more kinds of conjugate.If desired, also can add other components at deodorizer combinations of perfumes species of the present invention.
In deodorant compositions of the present invention and external preparation composition, according to desired form and dosage, normally used known solvent etc. can not damaged target effect of the present invention to a certain extent.That is to say that as solvent, oils content such as liquid oils and fat, liquid or solid oils and fat, solid oils and fat and wax etc., can be sneaked in the skin nursing external preparation composition.In addition, ester oil class, Hydrocarbon oils and silicones can be blended in deodorant compositions and the skin nursing external preparation composition.And surfactant can be sneaked into as solvent such as anion surfactant, cationic surfactant and amphoteric surfactant, oil loving nonionic surfactant, hydrophilic nonionic surfactant etc.
In addition, the polymer of lower alcohol, sterol, plant polymer, microorganism, starch material polymer, patho-amine polymer, cellulosic material polymer, alginic acid raw polymer, vinyl polymerization body, acrylic polymer and water-soluble polymer can be sneaked in the skin nursing external preparation composition as solvent.Metal ion sequestering agent, nertralizer, pH regulator agent etc. can be sneaked into the solvent as deodorant compositions and external preparation composition.
Solvents shown here etc. are example just, and that is to say, the solvent that can be blended in deodorant compositions of the present invention and the external preparation composition is not limited to these solvents.According to the prescription of desired form, solvent can be suitably in conjunction with being blended in deodorant compositions or the external preparation composition.The special formulation of deodorant compositions and external preparation composition will be described in the example below.
In addition, the flavor compositions that is used to suppress body odor of the present invention can be used as the method that suppresses to stick to easily owing to appear on the medicated clothing acidic smell on the medicated clothing, and suppresses because the method that sticks to the acidic smell on the medicated clothing that human body produces.Specifically, can adopt following form to use said composition, for example laundry with washing finishing agent, laundry with the smears etc.With regard to the compositions of using with above-mentioned form, according to the requirement of purpose, can mix and add fixative and similar material, for example inhibition body odor of the present invention is fixed on the effect target, on medicated clothing with flavor compositions.With regard to regard to the compositions of laundry washing finishing agent, the smears that is used to do washing etc., preferred composition is with the form of liquid additives and spray.
And the flavor compositions that is used for suppressing body odor of the present invention can join prescription, is used to prepare spice and can be prepared into required form and dosage form.As the form and the dosage form of these spice that so prepare, can be spice, cologne, lavatory perfume, deodorizer, soap, human body soap, shampoo, detergent etc. for instance.In this case, do not have specific restriction, but, preferably be about 0.001 to 20.0% weight with respect to whole amount of flavorants for the amount of sneaking into flavor compositions of the present invention in the spice.
The flavor compositions that is used for suppressing body odor of the present invention is blended into various deodorizer and external preparation composition, for by stink with perspiration, what particularly bromhidrosis came out is selected from the hydroxyl alkynyl carboxylic acid with 5 to 8 carbon atoms and has 5 to 8 a carbon atom and the acidic smell of the thiazolinyl carboxylic acid of two keys, shows fabulous masking effect and/or is in harmonious proportion effect.Sneak into deodorizer and the external preparation composition that is used to suppress the flavor compositions of body odor of the present invention therein, have so-called deodorizing effect as one of its purpose effect.That is to say, the flavor compositions that is used to suppress body odor of the present invention, comprise all so-called deodorizer, such as the external preparation of preparation for external application to skin etc., laundry with washing finishing agent or smears and spice etc.Laundry is with washing finishing agent or smears, and the release that it can be used for preventing adhering to easily the acidic smell on the medicated clothing etc. perhaps is used to prevent to be discharged into from human body the adhesion of the acidic smell on the medicated clothing.That is to say, deodorizer of the present invention and external preparation composition have more than and are limited to above-mentioned example, and it means that sneaking into all reagent that are used to suppress the flavor compositions of body odor of the present invention can effectively shelter and/or be in harmonious proportion because the stink with perspiration acidic smell that comes out of bromhidrosis particularly.
Therefore, deodorant compositions of the present invention and external preparation composition have the fabulous effect of sheltering and/or being in harmonious proportion the acidic smell in the body odor; Thereby, use said composition effectively to suppress because the body odor acidic smell that produces of bromhidrosis particularly.
Embodiment
Below, with reference to embodiment the present invention is described more specifically, still, the present invention is not limited to the following example and comparative example.
Has the plan stink with perspiration compositions that is used to estimate of composition shown in table 2 and 3, overall merit on the basis of following evaluation methodology according to the standard method preparation.Its result is shown in table 2 and 3 together.
Evaluation methodology:
Use a cup (about 500 milliliters of volume), wherein the stink with perspiration analog and the abnormal smells from the patient of bromhidrosis analog are estimated.The filter paper of 2cm * 2cm that will have the pseudo body odor compositions of 200 μ l is put into cup, carries out the abnormal smells from the patient evaluation by four members of expert group according to following standard.As a result, four panels of expert estimate on average counts and is suitable as the pseudo body odor compositions that is used to estimate by identification less than 3 pseudo body odor compositions.Evaluation criterion:
1: feel the body odor of similar particularly stink with perspiration and bromhidrosis significantly.
2: feel the body odor of similar stink with perspiration and bromhidrosis fully.
3: feel the body odor of similar stink with perspiration and bromhidrosis slightly.
4: the body odor of almost imperceptible similar stink with perspiration and bromhidrosis.
Table 2
| Composition (% weight) | |
Embodiment 2 | Embodiment 3 | Embodiment 4 |
| 3-hydroxy-3-methyl caproic acid (raceme) | 13.00 | 5.00 | 5.00 | 0.00 |
| 3-hydroxy-3-methyl caproic acid (enantiomer ratio: R/S=1/3) | 0.00 | 0.00 | 0.00 | 13.00 |
| 3-methyl-2-hexenoic acid (transisomer/cis-isomer=1/1) | 5.00 | 13.00 | 5.00 | 5.00 |
| Acetic acid | 11.85 | 11.85 | 12.60 | 11.85 |
| Isopropylformic acid. | 3.95 | 3.95 | 4.20 | 3.95 |
| Butanoic acid | 0.79 | 0.79 | 0.84 | 0.79 |
| Isovaleric acid | 3.95 | 3.95 | 4.20 | 3.95 |
| Caproic acid | 0.79 | 0.79 | 0.84 | 0.79 |
| Enanthic acid | 0.79 | 0.79 | 0.84 | 0.79 |
| Sad | 0.79 | 0.79 | 0.84 | 0.79 |
| N-nonanoic acid | 0.79 | 0.79 | 0.84 | 0.79 |
| Lactic acid | 55.30 | 55.30 | 58.80 | 55.30 |
| Hexanal | 0.60 | 0.60 | 1.20 | 0.60 |
| Octanal | 0.36 | 0.36 | 0.72 | 0.36 |
| Aldehyde C-9 | 0.09 | 0.09 | 0.18 | 0.09 |
| Capraldehyde | 0.90 | 0.90 | 1.80 | 0.90 |
| Undecyl aldehyde | 0.60 | 0.60 | 1.20 | 0.60 |
| Dodecyl aldehyde | 0.23 | 0.23 | 0.45 | 0.23 |
| Benzyl benzoate | 0.23 | 0.23 | 0.45 | 0.23 |
| Triethyl citrate | 0.00 | 0.00 | 0.00 | 5.00 |
| Total amount | 100.0 | 100.0 | 100.0 | 100.0 |
| Body odor (stink with perspiration and bromhidrosis) analog | 1.0 | 2.0 | 2.0 | 1.0 |
Table 3
| Composition (% weight) | Embodiment 5 | Embodiment 6 | Embodiment 7 | Comparative example 1 |
| 3-hydroxy-3-methyl caproic acid (raceme) | 13.00 | 0.00 | 0.00 | 0.00 |
| 3-hydroxy-3-methyl caproic acid (enantiomer ratio: R/S=1/3) | 0.00 | 0.00 | 13.00 | 0.00 |
| 3-methyl-2-hexenoic acid (transisomer/cis-isomer=1/1) | 0.00 | 13.00 | 0.00 | 0.00 |
| Acetic acid | 11.85 | 11.85 | 11.85 | 11.85 |
| Isopropylformic acid. | 3.95 | 3.95 | 3.95 | 3.95 |
| Butanoic acid | 0.79 | 0.79 | 0.79 | 0.79 |
| Isovaleric acid | 3.95 | 3.95 | 3.95 | 3.95 |
| Caproic acid | 0.79 | 0.79 | 0.79 | 0.79 |
| Enanthic acid | 0.79 | 0.79 | 0.79 | 0.79 |
| Sad | 0.79 | 0.79 | 0.79 | 0.79 |
| N-nonanoic acid | 0.79 | 0.79 | 0.79 | 0.79 |
| Lactic acid | 55.30 | 55.30 | 55.30 | 55.30 |
| Hexanal | 0.60 | 0.60 | 0.60 | 0.60 |
| Octanal | 0.36 | 0.36 | 0.36 | 0.36 |
| Aldehyde C-9 | 0.09 | 0.09 | 0.09 | 0.09 |
| Capraldehyde | 0.90 | 0.90 | 0.90 | 0.90 |
| Undecyl aldehyde | 0.60 | 0.60 | 0.60 | 0.60 |
| Dodecyl aldehyde | 0.23 | 0.23 | 0.23 | 0.23 |
| Benzyl benzoate | 0.23 | 0.23 | 0.23 | 0.23 |
| Triethyl citrate | 5.00 | 5.00 | 5.00 | 18.00 |
| Total amount | 100.0 | 100.0 | 100.0 | 100.0 |
| Body odor (stink with perspiration and bromhidrosis) analog | 2.5 | 2.0 | 2.0 | 3.5 |
Can find out obviously that from the result of table 2 and 3 embodiment 1～7th, present creative product, it all is fabulous product as the pseudo body odor compositions that is used to estimate.In addition, for 3-hydroxy-3-methyl caproic acid, from evaluation result as can be seen, used the raceme of 3-hydroxyl 3-methylhexanoic acid among the embodiment 5, used among the embodiment 7 and had the enantiomer ratio and be: the 3-hydroxy-3-methyl caproic acid of R/S=1/3, discovery has the enantiomer ratio: the evaluation of the body odor analog of the 3-hydroxy-3-methyl caproic acid of R/S=1/3 is higher than and has raceme, that is, having the enantiomer ratio is: the 3-hydroxy-3-methyl caproic acid of R/S=1/3 is better than has raceme.
Embodiment 8
Use chemical compound as shown in table 4 and flavor compositions A, carrying out inhibition test according to the operation of following experiment embodiment 1 estimates for the masking effect of body odor (stink with perspiration and bromhidrosis) and the effect that is in harmonious proportion, according to following evaluation criterion evaluation test project, show evaluation result with evaluation of estimate.Its result is shown in Table 4 together.In addition, the composition of flavor compositions A is shown in Table 5 in the table 4.
Filter paper with and the pseudo body odor compositions that have as following table 6 shown in composition that obtain of 2cm * 2cm according to embodiment 4 with 200 μ l, and the filter paper of 2cm * 2cm with 10 μ l spice, put into the about 500 milliliters cup of volume, use foil sealing then.After 30 minutes, in aluminium foil, form the about 1 centimetre hole of diameter, carry out masking effect and be in harmonious proportion Research on effect by four members of expert group according to following evaluation criterion.
The evaluation criterion of masking effect:
3: shelter admirably.
2: shelter admirably basically.
1: feel body odor (fetid sweat and bromhidrosis) slightly.
0: feel body odor (fetid sweat and bromhidrosis) (inadequate sheltering).
Mediation Evaluation on effect standard:
1: be in harmonious proportion.
0: uncertain.
-1: incongruity.
Table 4
| Shelter | Be in harmonious proportion | |
| 2-acetyl-2,3,8,8-tetramethyl octahydro-naphthalene (octarin) | 1 | -1 |
| β-damascone | 2 | 1 |
| Cetone gamma | 2 | 1 |
| Ethyl linalool | 1.5 | 0 |
| Acetaminol | 1.5 | 0 |
| Coumarin | 2.5 | 1 |
| Geraniol | 2 | 1 |
| Phenethyl acetate | 2.5 | 1 |
| Cis-3-hexenyl salicylate | 2 | 1 |
| Cis-jasmone | 1 | -1 |
| Citronellol | 2.5 | 1 |
| Phenethanol | 2.5 | 1 |
| The phenylethyl isopropyl alcohol | 1.5 | -1 |
| Heliotropine | 1.5 | 0 |
| Benzaldehyde | 3 | 1 |
| Frambinone | 0.5 | -1 |
| |
1 | 0 |
| Fructus Citri Limoniae oil | 3 | 1 |
| Oleum Rosae Rugosae | 2.5 | 1 |
| The Flos Rosae Rugosae oxide | 3 | 1 |
| Flavor compositions A | 2.5 | 1 |
Table 5
| Composition | Weight portion |
| 2-acetyl-2,3,8,8-tetramethyl octahydro-naphthalene (octarin) | 200 |
| Cetone gamma | 5 |
| The methylamino benzoate | 4 |
| Coumarin | 5 |
| Geraniol | 80 |
| Trichloromethyl benzyl acetate | 20 |
| Phenethyl acetate | 100 |
| Cis-3-hexenyl salicylate | 20 |
| Cis- |
1 |
| Citronellol | 50 |
| Farnesol | 50 |
| Phenethanol | 90 |
| The phenylethyl isopropyl alcohol | 180 |
| Heliotropine | 100 |
| Linalool | 50 |
| Oleum Santali albi | 15 |
| Oleum bergamottae | 10 |
| Rhythm oil (Rhyme oil) | 10 |
| Fructus Citri Limoniae oil | 10 |
| Total amount | 1000 |
Table 6
| The composition of pseudo body odor | % weight |
| 3-hydroxy-3-methyl caproic acid (enantiomer ratio: R/S=1/3) | 13.00 |
| 3-methyl-2-hexenoic acid (transisomer/cis-isomer=1/1) | 5.00 |
| Acetic acid | 11.85 |
| Isopropylformic acid. | 3.95 |
| Butanoic acid | 0.79 |
| Isovaleric acid | 3.95 |
| Caproic acid | 0.79 |
| Enanthic acid | 0.79 |
| Sad | 0.79 |
| N-nonanoic acid | 0.79 |
| Lactic acid | 55.30 |
| Hexanal | 0.60 |
| Octanal | 0.36 |
| Aldehyde C-9 | 0.09 |
| Capraldehyde | 0.90 |
| Undecyl aldehyde | 0.60 |
| Dodecyl aldehyde | 0.23 |
| Benzyl benzoate | 0.23 |
| Triethyl citrate | 5.00 |
| Total amount | 100.00 |
Embodiment 9
According to the operation of above-mentioned EXPERIMENTAL EXAMPLE 1, adopt the mode identical to suppress experiment with embodiment 8, estimate the masking effect and the mediation effect of the body odor (fetid sweat and bromhidrosis) of Multitest project.Based on its result, the component (I) of having selected the flavor compositions that is used to suppress body odor of the present invention is to (III).Select the results are shown in following table 7-1 to 7-4 (I group), show 8-1 to 8-3 (II group) with show 9-1 in 9-3 (III group).
Table 7-1
| The I group | Shelter | Be in harmonious proportion |
| Cis-3-hexenol | 3 | 1 |
| Cis-3-hexenyl acetate | 3 | 1 |
| Tripral | 3 | 1 |
| Styrylallyl acetate | 3 | 1 |
| Allyl amyl glycolate. | 3 | 1 |
| Citronellal | 3 | 1 |
| Citrathal | 3 | 1 |
| Hexanal | 3 | 1 |
| Octanal | 3 | 1 |
| Benzaldehyde | 3 | 1 |
| 2,6-dimethyl-5-heptenal | 3 | 1 |
| Vigorose | 3 | 1 |
| Camphora | 3 | 1 |
| Essence of Niobe | 3 | 1 |
| P-Tolyl methyl ether | 3 | 1 |
| Citral | 3 | 1 |
| Geranonitrile | 3 | 1 |
| 3,7-Dimethyl-6-octenenitrile | 3 | 1 |
| Methyl heptenone | 3 | 1 |
| Ethyl acetoacetate | 3 | 1 |
| Allyl bexanoate | 3 | 1 |
Table 7-2
| The I group | Shelter | Be in harmonious proportion |
| Ethyl-2-methyl butyrate | 3 | 1 |
| Ethyl-2-methyl valerate | 3 | 1 |
| α-Dynascone | 3 | 1 |
| Phenyl acetyl acetaldehyde | 3 | 1 |
| Cover logical (Mentone) | 3 | 1 |
| The 1-carvone | 3 | 1 |
| L-Flos Rosae Rugosae oxide | 3 | 1 |
| Phenethanol | 2.5 | 1 |
| Phenethyl acetate | 2.5 | 1 |
| Citronellol | 2.5 | 1 |
| Benzyl acetate | 2.5 | 1 |
| Levosandol | 2.5 | 1 |
| Sandalmysore core | 2.5 | 1 |
| γ-undecalactone | 2.5 | 1 |
| Coumarin | 2.5 | 1 |
| Ethyl vanillin | 2.5 | 1 |
| Borneolum Syntheticum | 2.5 | 1 |
| Koavone | 2.5 | 1 |
| Methyl phenylacetate | 2.5 | 1 |
| Isocyclocitral | 2.5 | 1 |
| Cyclogalbanate | 2.5 | 1 |
Table 7-3
| The I group | Shelter | Be in harmonious proportion |
| Acetaldehyde (Acetoaldehyde) phenylethyl propyl group acetal | 2.5 | 1 |
| The methylamino benzoate | 2.5 | 1 |
| The 4-methoxybenzaldehyde | 2.5 | 1 |
| γ-arbricolin (γ-Nonalactone) | 2.5 | 1 |
| γ-Ding position decalactone (γ-Decalactone) | 2.5 | 1 |
| Geraniol | 2 | 1 |
| Damascenone | 2 | 1 |
| Cis-3-hexenyl salicylate | 2 | 1 |
| The methyl ionone soap | 2 | 1 |
| Ambroxan | 2 | 1 |
| 2-tert-butylcyclohexyl acetas | 2 | 1 |
| β-damascone | 2 | 1 |
| Methyl jasmonate | 2 | 1 |
| Methyl ionone | 2 | 1 |
| Isobutylquinoline. | 2 | 1 |
| Phenyl acetaldehyde (Phenylactoaldehyde) dimethyl-acetal | 2 | 1 |
| Anrantiol | 2 | 1 |
| The betanaphthol methyl ether | 2 | 1 |
| Fructus Citri Limoniae oil | 3 | 1 |
| Rhythm oil (Rhyme oil) | 3 | 1 |
| Orange oil | 3 | 1 |
Table 7-4
| The I group | Shelter | Be in harmonious proportion |
| Oil of rosemary | 3 | 1 |
| Cananga odorata oil | 3 | 1 |
| Mandarin oil | 3 | 1 |
| Chamomile oil | 3 | 1 |
| Cardamom oil | 3 | 1 |
| Citronella oil | 3 | 1 |
| Elemi oil | 3 | 1 |
| Mugwort oil | 3 | 1 |
| Ancient paulin face cream oil | 3 | 1 |
| Oleum menthae | 3 | 1 |
| Eucalyptus oil | 2.5 | 1 |
| Lavandin oil | 2.5 | 1 |
| Oleum Cinnamomi | 2.5 | 1 |
| Petitgrain oil | 2.5 | 1 |
| Salvia Sclare L.oil | 2.5 | 1 |
| Flos Caryophylli oil | 2.5 | 1 |
| Oleum Rosae Rugosae | 2.5 | 1 |
| Basil oil | 2.5 | 1 |
| Oleum Pelargonii Graveolentis | 2 | 1 |
| Flos Tagetis Erectae oil (Taget oil) | 2 | 1 |
| Oleum Menthae Rotundifoliae | 2 | 1 |
Table 8-1
| The II group | Shelter | Be in harmonious proportion |
| The bright basic ionone of alkene | 2.5 | 0 |
| 4-methyl-3-decyl-5-alcohol | 2.5 | 0 |
| The bright basic ring hexyl of alkene propionic ester | 2 | 0 |
| The tyerpinyl acetate | 2 | 0 |
| α-damascone | 2 | 0 |
| 2,6-Dimethyl-2-octanol | 2 | 0 |
| The 4-tert-butyl group-2, the 6-dimethyl acetophenone | 2 | 0 |
| Phenylethyl phenylacetate | 2 | 0 |
| Ethyl-3-methyl-3-phenyl glycidyl acid esters | 2 | 0 |
| Styrene acetaldehyde | 2 | 0 |
| Thesaron | 2 | 0 |
| Ethyl linalool | 1.5 | 0 |
| Tricyclodecenyl acetate | 1.5 | 0 |
| NSC 4893 | 1.5 | 0 |
| δ-damascone | 1.5 | 0 |
| The sub-phenol of fourth | 1.5 | 0 |
| Heliotropine | 1.5 | 0 |
| Tonalid | 1.5 | 0 |
| Three decene-2-nitrile | 1.5 | 0 |
Table 8-2
| The II group | Shelter | Be in harmonious proportion |
| 9-decen-1-ol | 1.5 | 0 |
| 2-methyl ten-aldehyde | 1.5 | 0 |
| 4-tricyclo decene butyraldehyde | 1.5 | 0 |
| Patchone | 1.5 | 0 |
| Dimethyl octanol | 1.5 | 0 |
| Diphenyl ether | 1.5 | 0 |
| The Flos Rosae Rugosae phenyl ketone | 1.5 | 0 |
| Floralozone | 1.5 | 0 |
| Dihydro base Flos Rosae Rugosae oxide | 1.5 | 0 |
| Myrac aldehyde (Myracaldehyde) | 1.5 | 0 |
| Anisyl acetate | 1.5 | 0 |
| Ambretone | 1.5 | 0 |
| |
1 | 0 |
| |
1 | 0 |
| |
1 | 0 |
| |
1 | 0 |
| |
1 | 0 |
| |
1 | 0 |
Table 8-3
| The II group | Shelter | Be in harmonious |
| Dihydro jasmone | ||
| 1 | 0 | |
| Cedar oil | 2 | 0 |
| Juniper berry oil | 2 | 0 |
| Oleum thymi vulgaris | 2 | 0 |
| Oleum Pelargonii Graveolentis | 1.5 | 0 |
| Semen Myristicae oil | 1.5 | 0 |
Table 9-1
| The III group | Shelter | Be in harmonious proportion |
| Lauryl aldehyde | 1.5 | -1 |
| Dihydro base myrcenol | 1.5 | -1 |
| Vertenex | 1.5 | -1 |
| Cyclamen aldehyde | 1.5 | -1 |
| β-ionone | 1.5 | -1 |
| Woodyflor | 1.5 | -1 |
| Phenylethyl dimethyl carbinol | 1.5 | -1 |
| Cumal | 1.5 | -1 |
| Fruitate | 1.5 | -1 |
| 1-Naphthylethanone | 1.5 | -1 |
| Indole | 1.5 | -1 |
| Aldehyde C-9 | 1.5 | -1 |
| Luxuriant alkane ester | 1 | -1 |
| Linalyl acetate | 1 | -1 |
| Cyclaprop | 1 | -1 |
Table 9-2
| The III group | Shelter | Be in harmonious proportion |
| Geranyl acetate | 1 | -1 |
| Jasmonal H | 1 | -1 |
| Benzyl salicylate | 1 | -1 |
| The hexyl salicylate | 1 | -1 |
| Iso E super | 1 | -1 |
| 2,6,10-trimethyl-9-undecenal | 1 | -1 |
| Homomyracaldehyde | 1 | -1 |
| The 2-phenyl propanol | 1 | -1 |
| Benzyl acetate | 1 | -1 |
| 2-Phenylethyl salicylate | 1 | -1 |
| Thymol | 1 | -1 |
| Capraldehyde | 1 | -1 |
| The 1-menthol | 1 | -1 |
| Dimethyl benzyl methylene diacetate ester | 1 | -1 |
| Cis-jasmone | 1 | -1 |
| Step Europe (Myol) | 1 | -1 |
| Cedramber | 1 | -1 |
| Santalex | 0.5 | -1 |
| Frambinone | 0.5 | -1 |
Table 9-3
| The III group | Shelter | Be in harmonious proportion |
| Galaxolide | 0.5 | -1 |
| Astrotone | 0.5 | -1 |
| Floramat | 0.5 | -1 |
| 2,2-dimethyl-3-(3-aminomethyl phenyl) propanol | 0.5 | -1 |
| 3-lauric aldehyde (dodecenal) | 0.5 | -1 |
| α, the alpha-alpha-dimethyl phenylethyl | 0.5 | -1 |
| Amber core | 0.5 | -1 |
| Evernyl | 0 | -1 |
| Oxalide | 0 | -1 |
| Cedryl acetate. | 0 | -1 |
| Ambestol | 0 | -1 |
Embodiment 10 and comparative example 2
According to the prescription of following table 10 (10-1 and 10-2), prepare the detergent use flavor compositions of embodiment 10 and comparative example 2 according to standard method, estimate its masking effect and be in harmonious proportion effect according to the method for EXPERIMENTAL EXAMPLE 1.This prescription is based on weight portion (the same prescription that is suitable for following flavor compositions).
Table 10-1 (flavor compositions that is used for detergent)
| Embodiment 10 | Comparative example 2 | |
| Fructus Citri Limoniae oil | 250 | |
| Rhythm oil (Rhyme oil) | 100 | |
| 3,7-Dimethyl-6-octenenitrile | 70 | 70 |
| |
1 | 1 |
| Octanal | 8 | 8 |
| The 2-methyl hendecanal | 24 | |
| Lauryl aldehyde | 24 | |
| Cis-3-hexenol | 5 | 5 |
| Tripral | 40 | 40 |
| Eucalyptus oil | 20 | 20 |
| 2,6-Dimethyl-2-octanol | 100 | |
| Dihydro base myrcenol | 450 | |
| Lavandin oil | 100 | |
| Linalool | 40 | |
| Linalyl acetate | 60 | |
| 2-tert-butylcyclohexyl acetate | 20 | |
| To the tert-butylcyclohexyl acetate | 20 | |
| Tricyclodecenyl acetate | 20 | |
| Cyclaprop | 20 | |
| Citronellol | 30 | 30 |
Table 10-2 (continuous table 10-1)
| L-Flos Rosae Rugosae oxide | 5 | 5 |
| Lilestralis | 60 | |
| Jasmonal H | 60 | |
| Floralozone | 2 | 2 |
| Koavone | 30 | |
| Woodyflor | 30 | |
| Methyl ionone soap | 30 | |
| β-ionone | 30 | |
| The 4-methoxybenzaldehyde | 10 | |
| Heliotropine | 10 | |
| Dipropylene glycol | 75 | 75 |
| Total amount | 1000 | 1000 |
The detergent use flavor compositions of embodiment 10 comprises 719/1000 component (I), 206/1000 component (II), 0/1000 component (III) and other components of 75/1000.On the other hand, the flavor compositions of comparative example 2 comprises 179/1000 component (I), 12/1000 component (II), 694/1000 component (III) and other components of 115/1000.
The evaluation of estimate of the masking effect of the detergent use flavor compositions of embodiment 10 is 3.0, and the Evaluation on effect value that is in harmonious proportion is 1.0.Can find that from evaluation of estimate the flavor compositions of embodiment 10 is fabulous for the masking effect of acidic smell and the effect that is in harmonious proportion.
On the contrary, be 1.0 according to the evaluation of the masking effect of the detergent use flavor compositions of comparative example 2, the Evaluation on effect value that is in harmonious proportion is 0.0.From evaluation of estimate as can be seen, according to the masking effect of the detergent use flavor compositions of comparative example 2 and be in harmonious proportion the effect both can not be satisfactory.
In addition, detergent use flavor compositions of the present invention can prepare cloth-washing detergent through mixing according to following prescription, and it can be used as deodorant compositions of the present invention.As described below, because masking action and mediation effect, this detergent shows the effect of fabulous inhibition acidic smell.
Embodiment 11 and comparative example 3
According to the formulation examples of following cloth-washing detergent, the detergent use flavor compositions of mix embodiment 10 and comparative example 2 prepares cloth-washing detergent.
The formulation examples of laundry detergent
| Component | % weight |
| Linear neopelex alpha-sulfo fatty acid methyl ester sodium salt dodecanol EO (25) adduct C12 is to the fatty acid sodium salt zeolite sodium metasilicate sodium carbonate polyethylene glycol carboxymethyl cellulose flavor compositions sodium sulphate of C13 | 10 10 25 20 7 17 115 surpluses |
| Total amount | 100 |
Under following experiment condition, adopt the detergent of embodiment 11 and comparative example 3 to wash,, compare and estimate because the odour intensity of the acidic smell in the medicated clothing that bromhidrosis causes by five members of expert group according to following evaluation criterion.The result is shown in the following table 11.Can find out obviously that from table 11 medicated clothing of the laundry detergent washing of use embodiment 10 shows the effect of fabulous inhibition acidic smell, this is because the masking action and the mediation effect of the detergent use flavor compositions of embodiment 9.
On the contrary, use the medicated clothing of the laundry detergent washing of comparative example 3 to show that inadequate acidic smell suppresses effect, even after rinsing, still can detect acidic smell.
Experiment condition: after having a bath, the candidate with strong bromhidrosis is wearing a vest, and the gauze that washing is good is in advance tied up at the position that directly contacts with axillary fossa.After 24 hours, washing and rinsing gauze dewater then.Estimate the abnormal smells from the patient afterwards that just dewatered by 5 members of expert group.
Evaluation criterion:
Zero: acidic smell is fully suppressed.
△: feel slight acidic smell.
*: feel tangible acidic smell.
Evaluation result:
Table 11
| Embodiment 11 | Comparative example 3 | |
| Estimate | ○ | △ |
Embodiment 12 and comparative example 4
According to the prescription of following table 12 (12-1 and 12-2), prepare the soap flavor compositions of embodiment 12 and comparative example 4 according to standard method, estimate its masking effect and be in harmonious proportion effect according to the method for EXPERIMENTAL EXAMPLE 1 then.
Table 12-1 (flavor compositions that is used for soap)
| Embodiment 12 | Comparative example 4 | |
| 9-decen-1-ol | 25 | |
| Lauryl aldehyde | 25 | |
| Oleum Pelargonii Graveolentis | 10 | 10 |
| 2,6-Dimethyl-2-octanol | 50 | |
| Dihydro base myrcenol | 50 | |
| Terpinyl acetate | 50 | |
| Lavandin oil | 100 | |
| Linalool | 40 | |
| Linalyl acetate | 110 | |
| 2-tert-butylcyclohexyl acetate | 100 | |
| To the tert-butylcyclohexyl acetate | 100 | |
| Tricyclodecenyl acetate | 10 | |
| Cyclacrop | 10 | |
| Patchone | 5 | 5 |
| Phenethanol | 250 | |
| Jasmonal H | 250 | |
| Citronellal | 80 | |
| Benzyl acetate | 80 | |
| Dorinone | 3 | 3 |
| L-Flos |
1 | 1 |
| Benzyl acetate | 30 | 30 |
Table 12-2 (continuous table 12-1)
| Lilestralis | 50 | |
| Cis p-isopropyl hexahydrobenzyl alcohol | 50 | |
| The methyl ionone soap | 75 | |
| Woodyflor | 75 | |
| |
1 | 1 |
| Bacdanol | 10 | |
| Santalex | 10 | |
| Heliotropine | 50 | |
| Coumarin | 50 | |
| Tonalid | 50 | |
| Glaxolide | 100 | |
| Dipropylene glycol | 50 | |
| Total amount | 1000 | 1000 |
Comprise 710/1000 component (I), 240/1000 component (II), 0/1000 component (III) and other components of 50/1000 according to the soap of embodiment 12 with flavor compositions; On the other hand, comprise 45/1000 component (I), 55/1000 component (II), 860/1000 component (III) and other components of 40/1000 according to the flavor compositions of comparative example 4.
Is 3.0 according to the soap of embodiment 12 with the evaluation of estimate of the masking effect of flavor compositions, and the Evaluation on effect value that is in harmonious proportion is 1.0.Can find that from evaluation of estimate the flavor compositions of embodiment 12 is fabulous for the masking effect of acidic smell and the effect that is in harmonious proportion.
On the contrary, be 1.0 according to the soap of comparative example 4 with the evaluation of the masking effect of flavor compositions, the Evaluation on effect value that is in harmonious proportion is 0.0, that is to say, according to the soap of comparative example 4 with the masking effect of flavor compositions and be in harmonious proportion the effect both can not be satisfactory.
Embodiment 13 and comparative example 5
According to the embodiment of following soap prescription, the soap of sneaking into embodiment 12 and comparative example 4 prepares soap with flavor compositions.
The embodiment of soap prescription
| Component | % calculates by weight |
| Coconut/perm fatty acid oil sodium salt coconut/perm fatty acid oil dibutyl hydroxy toluene ethylenediamine tetra-acetic acid citric acid titanium dioxide flavor compositions is purified waste water | 90 3 0.1 0.1 0.5 0.3 1 surpluses |
| Total amount | 100 |
Under the following conditions, use the soap of embodiment 13 and comparative example 5, after using, compare and estimate the odour intensity of the acidic smell that causes owing to bromhidrosis by five members of expert group.The results are shown in the following table 13.Can find out obviously that from table 13 when the soap that adopts embodiment 13 washs, find to use owing to the soap of embodiment 12 masking action and the mediation effect of flavor compositions, the acidic smell in the gauze obtains fabulous inhibition.On the contrary, when the soap that adopts comparative example 5 washs, can aware the acidic smell in the gauze.
Experiment condition: after having a bath, the candidate with strong bromhidrosis is wearing a vest, and the gauze that washing is good is in advance tied up at the position that directly contacts with axillary fossa.After 24 hours, soap and wash gauze, and rinsing, dehydration then.Estimate the abnormal smells from the patient afterwards that just dewatered by 5 members of expert group.
Evaluation criterion:
Zero: acidic smell is fully suppressed.
△: perceive slight acidic smell.
*: perceive tangible acidic smell.
Evaluation result:
Table 13
| Embodiment 13 | Comparative example 5 | |
| Estimate | ○ | △ |
Embodiment 14 and comparative example 6
According to prescription shown in the following table 14 (14-1 and 14-2), prepare the body soap perfume compositions of embodiment 14 and comparative example 6 according to standard method, estimate its masking effect and be in harmonious proportion effect according to the method for EXPERIMENTAL EXAMPLE 1 then.
Table 14-1 (flavor compositions that is used for the body soap)
| Embodiment 14 | Comparative example 6 | |
| Oleum bergamottae | 120 | |
| Linalool | 50 | |
| Linalyl acetate | 70 | |
| Fructus Citri Limoniae oil | 100 | |
| Rhythm oil (Rhyme oil) | 150 | |
| Dihydro base myrcenol | 250 | |
| 3,7-Dimethyl-6-octenenitrile | 20 | |
| Tridecylen-2-nitrile | 20 | |
| Octanal | 3 | |
| Capraldehyde | 3 | |
| Allyl hexanoate | 10 | |
| Fruitate | 10 | |
| Cis-3-hexenol | 2 | 2 |
| Styrylallyl acetate | 20 | |
| Floropal | 20 | |
| Citronellol | 80 | |
| Benzyl acetate | 80 | |
| Geraniol acetate | 20 | |
| Benzyl acetate | 20 | |
| Dimethyl benzene acetate ethanol ester | 40 |
Table 14-2 (continuous table 14-1)
| Dorinone | 10 | 10 |
| Lilestralis | 80 | |
| Cis p-isopropyl hexahydrobenzyl alcohol | 80 | |
| The methyl dihydro jasmone | 150 | |
| Jasmonal H | 150 | |
| Myracaldehyde | 15 | |
| 3-lauric aldehyde (dodecenal) | 15 | |
| Cis 3-hexenyl salicylate | 20 | |
| The hexyl salicylate | 20 | |
| The methyl ionone soap | 50 | |
| Woodyflor | 50 | |
| Ambroxan | 10 | |
| Evernyl | 10 | |
| Sandalmysore core | 20 | |
| Santalex | 20 | |
| Tonalid | 50 | |
| Glaxolide | 100 | |
| Dipropylene glycol | 50 | |
| Total amount | 1000 | 1000 |
The body soap perfume compositions of embodiment 14 comprises 665/1000 component (I), 165/1000 component (II), 0/1000 component (III) and other components of 170/1000.On the other hand, the flavor compositions of comparative example 6 comprises 12/1000 component (I), 40/1000 component (II), 898/1000 component (III) and other components of 50/1000.
Evaluation of estimate according to the masking effect of the body soap perfume compositions of embodiment 14 is 3.0, and the Evaluation on effect value that is in harmonious proportion is 1.0.Can find that from evaluation of estimate the flavor compositions of embodiment 14 is fabulous for the masking effect of acidic smell and the effect that is in harmonious proportion.
On the contrary, be 1.0 according to the evaluation of the masking effect of the body soap perfume compositions of comparative example 6, the Evaluation on effect value that is in harmonious proportion is 0.0, that is to say, according to the masking effect of the spice of comparative example 6 and be in harmonious proportion the effect both can not be satisfactory.
Embodiment 15 and comparative example 7
According to the embodiment with lower body soap prescription, the body soap perfume compositions of sneaking into embodiment 14 and comparative example 6 prepares the body soap.
The embodiment of body soap prescription
| Component | % weight |
| Potassium hydroxide sodium laurate lauryl polyethylene glycol oxide sulfuric ester pearling agent lauryl amido propyl betaine flavor compositions is purified waste water | 36 10 10 8 0.5 surpluses |
| Total amount | 100 |
Under the following conditions, use the body soap of embodiment 14 and comparative example 7, after using, compare and estimate the odour intensity of the acidic smell that causes owing to bromhidrosis by five members of expert group according to following evaluation criterion.The results are shown in the following table 15.Can find out obviously that from table 15 when the body soap that adopts embodiment 15 washs, find masking action and mediation effect owing to body soap perfume compositions, the acidic smell in the gauze obtains fabulous inhibition.On the contrary, when the body soap that adopts comparative example example 7 washs, can aware the acidic smell in the gauze.
Experiment condition: after having a bath, the candidate with strong bromhidrosis is wearing a vest, and the gauze that washing is good is in advance tied up at the position that directly contacts with axillary fossa.After 24 hours, soap with body and to wash gauze, and rinsing, dehydration then.Estimate the abnormal smells from the patient afterwards that just dewatered by 5 members of expert group.
Evaluation criterion:
Zero: acidic smell is fully suppressed.
△: perceive slight acidic smell.
*: perceive tangible acidic smell.
Evaluation result:
Table 15
| Embodiment 15 | Comparative example 7 | |
| Estimate | ○ | △ |
Embodiment 16 and comparative example 8
According to prescription shown in the following table 16 (16-1 and 16-2), prepare the deodorizer flavor compositions of embodiment 16 and comparative example 8 according to standard method, estimate its masking effect and mediation effect according to the method for EXPERIMENTAL EXAMPLE 1 then.
Table 16-1 (flavor compositions that is used for deodorizer)
| Embodiment 16 | Comparative example 8 | |
| Oleum bergamottae | 200 | |
| Linalool | 80 | |
| Linalyl acetate | 120 | |
| Fructus Citri Limoniae oil | 150 | 150 |
| Petitgrain oil | 10 | 10 |
| Cis-3-hexenol | 3 | 3 |
| Tripral | 3 | 3 |
| Pi-allyl amyl group oxyacetate | 3 | 3 |
| Ancient paulin |
1 | 1 |
| Salvia Sclare L.oil | 10 | 10 |
| Citronellol | 100 | 100 |
| Jessamona | 300 | |
| Benzyl acetate | 300 | |
| Dorinone | 10 | 10 |
| Benzyl acetate | 20 | 20 |
| β-Nai Jiami | 5 | 5 |
| Dihydro Flos Rosae Rugosae oxide | 80 | |
| Cis p-isopropyl hexahydrobenzyl alcohol | 80 | |
| Cis-3-hexenyl salicylate | 20 | |
| The hexyl salicylate | 20 | |
| Methyl ionone soap | 30 |
Table 16-2 (continuous table 16-1)
| β-ionone | 30 | |
| γ-undecalactone | 5 | 5 |
| Tonalid | 25 | |
| Glaxolide | 50 | |
| Dipropylene glycol | 25 | |
| Total amount | 1000 | 1000 |
The deodorizer of embodiment 16 comprises 670/1000 component (I), 105/1000 component (II), 0/1000 component (III) with flavor compositions) and other components of 225/1000.On the other hand, the flavor compositions of comparative example 8 comprises 320/1000 component (I), 0/1000 component (II), 600/1000 component (III) and other components of 80/1000.
Is 3.0 according to the deodorizer of embodiment 16 with the evaluation of estimate of the masking effect of flavor compositions, and the Evaluation on effect value that is in harmonious proportion is 1.0.Can find that from evaluation of estimate the flavor compositions of embodiment 16 is fabulous for the masking effect of acidic smell and the effect that is in harmonious proportion.
On the contrary, is 1.0 according to the deodorizer of comparative example 8 with the evaluation of the masking effect of flavor compositions, the Evaluation on effect value that is in harmonious proportion is 0.0, that is to say, can not be satisfactory with mediation effect both with the masking effect of flavor compositions according to the deodorizer of comparative example 8.
Embodiment 17 and comparative example 9
According to the embodiment of following prescription, the deodorizer of sneaking into embodiment 16 and comparative example 8 prepares washing liquid with flavor compositions, and this washing liquid is an external preparation composition.
The embodiment of deodorizer (washing liquid) prescription
| Component | ％ |
| Aluminium chlorohydrate ethanol hydroxyethylcellulose chlohexidine gluconate polyethylene glycol oxide PPOX cetyl ether flavor compositions is purified waste water | 35 35 0.6 0.2 2 0.5 surpluses |
| Total amount | 100 |
Under the following conditions, use the washing liquid of embodiment 17 and comparative example 9, after using, compare and estimate the odour intensity of the acidic smell that causes owing to bromhidrosis by five members of expert group according to following evaluation criterion.The results are shown in the following table 17.Can obviously find out from table 17, when the washing liquid that adopts embodiment 17 is handled, find that the acidic smell in the gauze obtains fabulous inhibition owing to be used for the masking action and the mediation effect of the flavor compositions of washing liquid.On the contrary, when the washing liquid that adopts comparative example 9 is washed, can aware the acidic smell in the gauze.
Experiment condition: after having a bath, the candidate with strong bromhidrosis handles an one axillary fossa and puts on a vest with deodorizer, and the gauze of getting well with washing is in advance directly tied up at the position that directly contacts with axillary fossa.After 24 hours, estimate the abnormal smells from the patient of gauze by 5 members of expert group.
Evaluation criterion:
Zero: do not make good use of than not making.
△: better a little than not using (awaring slight acidic smell).
*: be equivalent to not use (perceiving tangible acidic smell).
Evaluation result:
Table 17
| Embodiment 17 | Comparative example 9 | |
| Estimate | ○ | △ |
Embodiment 18 and comparative example 10
According to prescription shown in the following table 18 (18-1 and 18-2), prepare the deodorizer flavor compositions of embodiment 18 and comparative example 10 according to standard method, estimate its masking effect and mediation effect according to the method for EXPERIMENTAL EXAMPLE 1 then.
Table 18-1 (flavor compositions that is used for deodorizer)
| Embodiment 18 | Comparative example 10 | |
| Fructus Citri Limoniae oil | 60 | 60 |
| Mandarin oil | 40 | 40 |
| Oleum bergamottae | 250 | |
| Linalool | 100 | |
| Linalyl acetate | 150 | |
| Ethyl acetoacetate | 12 | 12 |
| Salvia Sclare L.oil | 8 | 8 |
| Dorinone | 20 | 20 |
| Jessamona | 300 | |
| Benzyl acetate | 300 | |
| Kovanol | 80 | |
| Mayol | 80 | |
| Floralozone | 5 | |
| 2,2-dimethyl-3-(3-aminomethyl phenyl) propanol | 5 | |
| Cis-3-hexenyl salicylate | 50 | |
| The hexyl salicylate | 50 | |
| Semen Myristicae oil | 3 | |
| Folium Caryophylli oil | 3 | |
| β-ionone | 30 |
Table 18-2 (continuing table 18-1)
| Iso E super | 30 | |
| Ambroxane | 2 | 2 |
| Sandalmysore core | 40 | |
| Santalex | 40 | |
| Tonalid | 50 | |
| Glaxolide | 100 | |
| Dipropylene glycol | 50 | |
| Total amount | 1000 | 1000 |
The deodorizer of embodiment 18 comprises 532/1000 component (I), 138/1000 component (II), 30/1000 component (III) and other components of 300/1000 with flavor compositions.On the other hand, the flavor compositions of comparative example 9 comprises 142/1000 component (I), 3/1000 component (II), 755/1000 component (III) and other components of 100/1000.
Is 3.0 according to the deodorizer of embodiment 18 with the evaluation of estimate of the masking effect of flavor compositions, and the Evaluation on effect value that is in harmonious proportion is 1.0.Can find that from evaluation of estimate the flavor compositions of embodiment 18 is fabulous for the masking effect of acidic smell and the effect that is in harmonious proportion.
On the contrary, is 1.0 according to the deodorizer of comparative example 10 with the evaluation of the masking effect of flavor compositions, the Evaluation on effect value that is in harmonious proportion is 0.0, that is to say, can not be satisfactory with mediation effect both with the masking effect of flavor compositions according to the deodorizer of comparative example 10.
Embodiment 19 and comparative example 11
According to the embodiment of following prescription, the deodorizer of sneaking into embodiment 18 and comparative example 10 prepares spray form deodorizer (washing liquid type) with flavor compositions, and this deodorizer is external preparation composition.
The embodiment of spray form deodorizer (washing liquid type) prescription
| Component | % weight |
| Hydroxyethylcellulose aluminium chlorohydrate ethanol propane diols talcum polyethylene glycol oxide list distearate flavor compositions is purified waste water | 0.6 18 10 15 73 0.05 surpluses |
| Total amount | 100 |
Under the following conditions, use the spray form deodorizer (washing liquid type) of embodiment 19 and comparative example 11, after using, compare and estimate the odour intensity of the acidic smell that causes owing to bromhidrosis by five members of expert group according to following evaluation criterion.The results are shown in the following table 19.Can obviously find out from table 19, when the spray form deodorizer that adopts embodiment 19 is handled, find that the acidic smell in the gauze obtains fabulous inhibition owing to be used for the masking action and the mediation effect of the flavor compositions of deodorizer.On the contrary, when the spray form deodorizer (washing liquid type) that adopts comparative example 11 when handling, even after using, can aware acidic smell in the gauze.
Experiment condition: after having a bath, the candidate with strong bromhidrosis handles an one axillary fossa and puts on a vest with deodorizer, and the gauze of getting well with washing is in advance directly tied up at the position that directly contacts with axillary fossa.After 24 hours, estimate the abnormal smells from the patient of gauze by 5 members of expert group.
Evaluation criterion:
Zero: do not make good use of than not making.
△: better a little than not using (awaring slight acidic smell).
*: be equivalent to not use (perceiving tangible acidic smell).
Evaluation result:
Table 19
| Embodiment 19 | Comparative example 11 | |
| Estimate | ○ | △ |
Embodiment 20 and comparative example 12
According to the embodiment of prescription shown in following, the deodorizer of preparation embodiment 18 and comparative example 10 is with the liquid storage of flavor compositions, and then preparation is as the aerosol (being used for aerosol container) of external preparation composition.
Aerocolloidal formulation Example (being used for aerosol container)
| Component | % calculates by weight |
| The liquid storage liquefied petroleum gas | 45 55 |
| Total amount | 100 |
Under the following conditions, use the aerosol of embodiment 20 and comparative example 12, after using, compare and estimate the odour intensity of the acidic smell that causes owing to bromhidrosis by five panels of expert according to following evaluation criterion.The results are shown in the following table 20.Can obviously find out from table 20, when the aerosol that adopts embodiment 20 is handled, find that the acidic smell in the gauze obtains fabulous inhibition owing to masking action and the mediation effect of using flavor compositions according to the deodorizer of embodiment 18.On the contrary, when the washing liquid that adopts comparative example 12 is handled, even after using, can aware acidic smell in the gauze.
Experiment condition: after having a bath, the candidate with strong bromhidrosis handles an one axillary fossa and puts on a vest with aerosol, and the gauze of getting well with washing is in advance directly tied up at the position that directly contacts with axillary fossa.After 24 hours, estimate the abnormal smells from the patient of gauze by 5 members of expert group.
Evaluation criterion:
Zero: do not make good use of than not making.
△: betterly a little than not using (aware slight acidic smell.)
*: be equivalent to not use (perceiving tangible acidic smell).
Evaluation result:
Table 20
| Embodiment 20 | Comparative example 12 | |
| Estimate | ○ | △ |
Embodiment 21 and comparative example 13
According to prescription shown in the following table 21, prepare the aerosol powder flavor compositions of embodiment 21 and comparative example 13 according to standard method, estimate its masking effect and mediation effect according to the method for EXPERIMENTAL EXAMPLE 1 then.
Table 21 (flavor compositions that is used for the aerosol powder)
| Embodiment 21 | Embodiment 21 | Comparative example 13 |
| Ethyl-2-methyl butyrate (methyl butylate) | 10 | 10 |
| Ethyl-2-methyl valerate | 50 | |
| Luxuriant alkane ester | 50 | |
| Allyl hexanoate | 80 | 80 |
| Pi-allyl amyl group oxyacetate | 30 | 30 |
| Tripral | 50 | 50 |
| Terpinyl acetate | 80 | |
| Linalyl acetate | 80 | |
| 2-tert-butylcyclohexyl acetate | 400 | |
| To the tert-butylcyclohexyl acetate | 400 | |
| Koavone | 150 | |
| Jasmonal H | 150 | |
| γ-undecalactone | 30 | 30 |
| Coumarin | 20 | |
| Heliotropine | 20 | |
| Tonalid | 50 | |
| Glaxolide | 100 | |
| Dipropylene glycol | 50 | |
| Total amount | 1000 | 1000 |
The aerosol powder of embodiment 21 comprises 820/1000 component (I), 130/1000 component (II), 0/1000 component (III) and other components of 50/1000 with flavor compositions.On the other hand, the flavor compositions of comparative example 13 comprises 200/1000 component (I), 20/1000 component (II), 780/1000 component (III) and other components of 0/1000.
Is 3.0 according to the aerosol powder of embodiment 21 with the evaluation of estimate of the masking effect of flavor compositions, and the Evaluation on effect value that is in harmonious proportion is 1.0.Can find that from evaluation of estimate the flavor compositions of embodiment 21 is fabulous for the masking effect of acidic smell and the effect that is in harmonious proportion.
On the contrary, is 1.0 according to the aerosol powder of comparative example 13 with the evaluation of the masking effect of flavor compositions, the Evaluation on effect value that is in harmonious proportion is 0.0, that is to say, can not be satisfactory with mediation effect both with the masking effect of flavor compositions according to the aerosol powder of comparative example 13.
Embodiment 22 and comparative example 14
According to the embodiment of following prescription, the aerosol powder of sneaking into embodiment 21 and comparative example 13 prepares the aerosol powder with flavor compositions, and this aerosol powder is a deodorant compositions.
The embodiment of aerosol powder powder formulation
| Component | % weight |
| Aluminium chloride hydroxide magnesia-silica silicic acid anhydride POE (20) glycerine three isostearate methyl polysiloxane decyl cyclopentasiloxane (Decamethyl cyclopentasiloxane) flavor compositions isopropyl myristates | 20 15 7 15 21 0.05 surpluses |
| Total amount | 100 |
Under the following conditions, use the aerosol powder of embodiment 22 and comparative example 14, after using, compare and estimate the odour intensity of the acidic smell that causes owing to bromhidrosis by five members of expert group according to following evaluation criterion.The results are shown in the following table 22.Can obviously find out from table 22, when the aerosol powder that adopts embodiment 22 is handled, find that the acidic smell in the gauze obtains fabulous inhibition owing to masking action and the mediation effect of using flavor compositions according to the deodorizer of embodiment 21.On the contrary, when the aerosol powder that adopts comparative example 14 is handled, even after using, can aware acidic smell in the gauze.
Experiment condition: after having a bath, the candidate with strong bromhidrosis handles an one axillary fossa and puts on a vest with aerosol, and the gauze of getting well with washing is in advance directly tied up at the position that directly contacts with axillary fossa.After 24 hours, estimate the abnormal smells from the patient of gauze by 5 members of expert group.
Evaluation criterion:
Zero: do not make good use of than not making.
△: better a little than not using (awaring slight acidic smell).
*: be equivalent to not use (perceiving tangible acidic smell).
Evaluation result
Table 22
| Embodiment 22 | Comparative example 14 | |
| Estimate | ○ | △ |
Embodiment 23 and comparative example 15
According to the embodiment of prescription shown in following, the aerosol powder of preparation embodiment 21 and comparative example 13 is with the liquid storage of flavor compositions, and then preparation is as the aerosol (being used for aerosol container) of deodorant compositions.
The formulation Example of aerosol powder (being used for aerosol container)
| Component | % calculates by weight |
| The liquid storage liquefied petroleum gas | 45 55 |
| Total amount | 100 |
Under the following conditions, use the aerosol powder of embodiment 23 and comparative example 15, after using, compare and estimate the odour intensity of the acidic smell that causes owing to bromhidrosis by five panels of expert according to following evaluation criterion.The results are shown in the following table 23.Can obviously find out from table 23, when the aerosol powder that adopts embodiment 23 is handled, find that the acidic smell in the gauze obtains fabulous inhibition owing to masking action and the mediation effect of using flavor compositions according to the powder of embodiment 21.On the contrary, when the aerosol powder that adopts comparative example 15 is handled, even after using, can aware acidic smell in the gauze.
Experiment condition: after having a bath, the candidate with strong bromhidrosis is with an aerosol powder-processed one axillary fossa and put on a vest, directly ties up at the position that directly contacts with axillary fossa with the gauze that washing is good in advance.After 24 hours, estimate the abnormal smells from the patient of gauze by 5 members of expert group.
Evaluation criterion:
Zero: do not make good use of than not making.
△: better a little than not using (awaring slight acidic smell).
*: be equivalent to not use (perceiving tangible acidic smell).
Evaluation result:
Table 23
| Embodiment 23 | Comparative example 15 | |
| Estimate | ○ | △ |
Claims (13)
1. pseudo body odor compositions, it is characterized in that: this pseudo body odor compositions comprises:
(A) at least a being selected from (A-1) has the hydroxyl alkynyl carboxylic acid of 5 to 8 carbon atoms and the thiazolinyl carboxylic acid that (A-2) has 5 to 8 carbon atoms and two keys;
(B) at least a fatty acid that is selected from 2 to 24 carbon atoms; With
(C) at least a aldehyde that is selected from 2 to 13 carbon atoms.
2. pseudo body odor compositions according to claim 1 is characterized in that: described component (A) comprising: (A-1) at least a hydroxyl alkynyl carboxylic acid with 5 to 8 carbon atoms that is selected from; With
(A-2) at least a thiazolinyl carboxylic acid that is selected from 5 to 8 carbon atoms and two keys.
3. according to claim 1 or 2 any one described pseudo body odor compositions, it is characterized in that: described component (A-1) is the raceme and the optically active form of at least a 3-of being selected from hydroxy-3-methyl caproic acid.
4. according to any one described pseudo body odor compositions of claim 1 to 3, it is characterized in that: described component (A-2) is the cis-isomer and the transisomer of at least a 3-of being selected from methyl-2-hexenoic acid.
5. one kind is used to estimate the method for sheltering, being in harmonious proportion or remove the stink with perspiration effect, it is characterized in that: use in the pseudo body odor compositions of claim 1 to 4 described in any one.
6. flavor compositions that is used to suppress body odor, it is characterized in that: this flavor compositions that is used to suppress body odor comprises at least a or multiple component of sheltering admirably and/or being in harmonious proportion the acidic smell effect that has, and described acidic smell is selected from the hydroxyl alkynyl carboxylic acid with 5 to 8 carbon atoms and has 5 to 8 carbon atoms and the thiazolinyl carboxylic acid of two keys.
7. the flavor compositions that is used to suppress body odor according to claim 6 is characterized in that: described acidic smell is 3-hydroxy-3-methyl caproic acid and/or 3-methyl hexenoic acid.
8. according to claim 6 or the 7 described flavor compositions that are used to suppress body odor, it is characterized in that: described have a component of sheltering admirably and/or being in harmonious proportion acidic smell, comprising:
(I) at least a or multiple chemical compound or the essential oil of being selected from, its fragrance shelter and be in harmonious proportion all show aspect the acidic smell effect fabulous;
(II) at least a or multiple chemical compound or the essential oil of being selected from, its fragrance is in that to shelter aspect the acidic smell performance fabulous, but in that to be in harmonious proportion aspect the acidic smell performance neutral; With
(III) as required, at least a or multiple chemical compound or the essential oil of being selected from, its fragrance all do not have effect aspect the acidic smell two sheltering and be in harmonious proportion.
9. the flavor compositions that is used to suppress body odor according to claim 8, it is characterized in that: wherein in gross weight, comprise 40% weight or above component (I), comprise 60% weight or above component (I) and (II), comprise the component (III) that is less than 40% weight.
10. deodorant compositions is characterized in that: described deodorant compositions comprises the flavor compositions of aforesaid right requirement 6 to the 9 inhibition body odor described in any one.
11. an external preparation composition is characterized in that: described external preparation composition comprises the flavor compositions of aforesaid right requirement 6 to the 9 inhibition body odor described in any one.
12. a method that suppresses body odor is characterized in that:, use following material for being selected from hydroxyl alkynyl carboxylic acid and having 5 to 8 carbon atoms and the acidic smell of the thiazolinyl carboxylic acid of two keys with 5 to 8 carbon atoms:
(A) at least a or multiple all have the chemical compound or the essential oil of excellent effect aspect the acidic smell sheltering and be in harmonious proportion;
(B) but at least a or multiple being selected from sheltering fabulously aspect the acidic smell is being in harmonious proportion neutral chemical compound or essential oil aspect the acidic smell; With
(C) as required, at least a or multiple being selected from sheltering and be in harmonious proportion all do not have the chemical compound or the essential oil of effect aspect the acidic smell two.
13. the method according to the inhibition body odor described in the claim 12 is characterized in that: described acidic smell is 3-hydroxy-3-methyl caproic acid and/or 3-methyl hexenoic acid.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP056017/2003 | 2003-03-03 | ||
| JP2003056017A JP2004263102A (en) | 2003-03-03 | 2003-03-03 | False body odor composition |
| JP057462/2003 | 2003-03-04 |
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| Publication Number | Publication Date |
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| CN1756525A true CN1756525A (en) | 2006-04-05 |
| CN100356901C CN100356901C (en) | 2007-12-26 |
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| CNB2004800058172A Expired - Fee Related CN100356901C (en) | 2003-03-03 | 2004-02-26 | Pseudo body odor composition and perfume composition for inhibiting body odor |
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| JP (1) | JP2004263102A (en) |
| CN (1) | CN100356901C (en) |
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|---|---|
| JP2004263102A (en) | 2004-09-24 |
| CN100356901C (en) | 2007-12-26 |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Shanghai Takasago-Union Fragrances & Flavors Co., Ltd. Assignor: Takamasago Perfume Industrial Co., Ltd. Contract fulfillment period: 2007.12.28 to 2013.12.27 contract change Contract record no.: 2008990000730 Denomination of invention: Pseudo body odor composition and perfume composition for inhibiting body odor Granted publication date: 20071226 License type: Exclusive license Record date: 20081014 |
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Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2007.12.28 TO 2013.12.27; CHANGE OF CONTRACT Name of requester: SHANGHAI TAKASAGO JIANCHEN SPICE CO., LTD. Effective date: 20081014 |
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Granted publication date: 20071226 Termination date: 20140226 |