JP2001271088A - Model composition of scalp smell for evaluation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a model composition of scalp smell for evaluation capable of evaluating a masking effect or suppressing effect of scalp smell, exactly and effectively screening materials having the effect. SOLUTION: This model composition of scalp smell for evaluation includes components, (A) proline or a peptide including proline, (B) squalene, (C) cholesterol or its derivative and (D) one or more kind of 2-24C fatty acids, and the invention includes an evaluation method for masking or suppressing effect of scalp smell using the composition.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an evaluation model scalp odor composition which is closer to the actual scalp odor and which can sufficiently reproduce the scalp peeled odor used for evaluating the masking or suppressing effect of the scalp odor. About things.

[0002]

2. Description of the Related Art Odors generated from the human body (human body odor) include typical breath odor, axillary odor, foot odor, scalp odor and body odor, which are generally unpleasant. From being impressed to the surroundings as a smell,
Many cosmetics or pharmaceuticals which mask the odor and consider deodorization / suppression have been developed and studied so far. Such an odor masking or deodorizing effect may be one of the functions of the product or may be a concept of the entire product, but in any case, in order to enhance the attractiveness of the product in product development. Plays an important role.

[0003] In order to evaluate the masking and deodorizing effects of such odors, it is difficult to obtain cooperation because it is necessary to carry out experiments that limit human lifestyle in order to obtain highly reproducible results for humans. In addition, when a new agent is used for evaluation, its safety also becomes a problem. In other words, if the evaluation model composition is used, it is possible to obtain a qualitative result in terms of functionality regardless of the presence or absence of safety in parallel with the examination while sufficiently examining the safety.

[0004] Therefore, a human body odor model for simply evaluating the masking and deodorizing effects and the like has been required.
Various human odor components such as bad breath, armpit odor, foot odor, scalp odor, and body odor have been studied. Of these, scalp odor has been studied mainly on components that give rise to “fatty odor” and “acid odor”, but a model odor closer to the actual scalp odor has not been obtained.

[0005] An object of the present invention is to provide a model scalp odor composition which is closer to the actual scalp odor and enables more accurate evaluation of masking and suppression of scalp odor, and a scalp using the composition. An object of the present invention is to provide a method for evaluating an odor masking or suppressing effect.

[0006]

Under such circumstances, the present inventors have analyzed the components obtained by solvent extraction and headspace extraction from human scalp using amino acid analysis, gas chromatography, mass spectrometry and the like. As a result, the actual scalp odor was not sufficient if only the “fatty odor” and “acid odor”, which were conventionally considered to be the cause of the scalp odor, were sufficient. Cannot be reproduced,
In addition to gaining the knowledge that it is necessary to consider three types of components including "unpleasant smell",
As a result of various studies on a model scalp odor composition that sufficiently reproduced the “unpleasant odor”, the specific compositions shown in the following (A) to (D) were closer to the actual scalp odor, It has been found that the effect of masking or suppressing odor can be accurately and simply evaluated, and a substance having the effect can be efficiently screened.

That is, the present invention provides the following component (A):
(B), (C) and (D); (A) proline or a proline-containing peptide, (B) squalene, (C) cholesterol or a derivative thereof, (D)
An object of the present invention is to provide a model scalp odor composition for evaluation containing at least one or more fatty acids having 2 to 24 carbon atoms.

The present invention also provides a method for evaluating the masking or suppressing effect of scalp odor, which comprises using the model scalp odor composition for evaluation.

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION Component (A) in the composition of the present invention
Is one of the amino acids that make up proteins, and this component is important in reproducing the “unpleasant odor” of the scalp odor. Here, `` unpleasant odor '' refers to a substance that expresses sweat as a causative substance and has a strong smell property in the presence of scalp oil, especially when moving from a space to another space in a crowded train or It instantly smells strong and causes a more unpleasant impression on others. The unpleasant smell is
Although the smell is weaker than the fat smell or the acid smell, it is not possible to construct a smell close to the actual scalp smell without considering the unpleasant smell.

[0010] The component (A) proline-containing peptide of the composition of the present invention is a peptide containing proline as a constituent amino acid, preferably an oligopeptide, which releases proline in the composition and is similar to proline. It emits an odor. The component (A) proline or proline-containing peptide can be contained in the entire composition in an amount of 0.001 to 50% by weight, and is particularly preferably added in the range of 0.005 to 20% by weight.

The squalene of the component (B) contains 2
0 to 60% by weight, especially 30 to 40% by weight.
It is preferable to mix in the range of weight%.

The cholesterol derivative of the component (C) is not particularly restricted but includes, for example, cholesterol esters and the like. Specifically, cholesterol undecanoate, cholesterol dodecanoate, cholesterol tridecanoate, tetradecane tetradecane Cholesterol esters of linear or branched saturated or unsaturated fatty acids having 11 to 16 carbon atoms, such as acid cholesterol ester, pentadecanoic acid cholesterol ester, palmitic acid cholesterol ester, and palmitoleic acid cholesterol ester are exemplified. Among them, cholesterol palmitate is particularly preferred from the viewpoint of versatility and odor.

In the present invention, cholesterol or a derivative thereof represented as the component (C) includes not only a case where cholesterol and a cholesterol derivative are contained alone but also a case where cholesterol and several cholesterol derivatives are simultaneously contained. It is. Component (C)
Cholesterol or a derivative thereof is 0.1 to
20% by weight, especially 1 to 10% by weight
It is preferable to mix in the range of.

The fatty acid having 2 to 24 carbon atoms of the component (D) includes, for example, acetic acid, propionic acid, butanoic acid, isobutanoic acid, valeric acid, isovaleric acid, octanoic acid, decanoic acid, dodecanoic acid, tridecanoic acid, and myristine. Examples thereof include straight-chain or branched saturated or unsaturated fatty acids such as acids, pentadecanoic acid, palmitic acid, palmitoleic acid, heptadecanoic acid, stearic acid, oleic acid, and linolenic acid. Of these, either acetic acid or propionic acid is an essential component in reproducing the acid odor of the actual scalp odor, and the scalp odor of the present invention is adjusted by adding other fatty acids to this. Can be. Here, other fatty acids include isobutyric acid, butyric acid, isovaleric acid, valeric acid, octanoic acid, dodecanoic acid, tridecanoic acid, myristic acid, pentadecanoic acid, palmitic acid, palmitoleic acid, heptadecanoic acid, stearic acid, and oleic acid. 4-18 carbon atoms such as linolenic acid
Are preferred examples. Among them, fatty acids having 8 to 18 carbon atoms are important for reproducing fat odor of scalp odor. As the component (D) fatty acid having 2 to 24 carbon atoms, particularly, acetic acid or propionic acid is used in an amount of 0.000
1 to 0.1% by weight of a fatty acid having 4 to 24 carbon atoms is 0.00
It is preferable to mix 1 to 50% by weight.

At least one selected from the group consisting of leucine, phenylalanine, serine, threonine, citrulline, valine, lysine, and arginine is important in reproducing the unpleasant odor of the actual scalp odor. It is a component, and particularly when used in combination with the component (A), its effects are sufficiently exhibited. The component (E) may be used alone or as a mixture of two or more, but particularly preferably a mixture of leucine and / or phenylalanine. Component (E) is, in the total composition of the composition of the present invention,
0.001 to 50% by weight,
It is preferable to mix in the range of 0.005 to 20% by weight.

The glyceride of the component (F) is, for example, a straight or branched chain having 2 to 24 carbon atoms such as decanoic acid, undecanoic acid, dodecanoic acid, tridecanoic acid, tetradecanoic acid, myristic acid, pentadecanoic acid, palmitic acid and palmitoleic acid. Means a glyceride of a saturated or unsaturated fatty acid,
Any of mono-, di-, and tri-fatty acid glycerides are included, and among them, triglycerides are preferable, and linear or branched saturated or unsaturated fatty acid triglycerides having 16 carbon atoms such as palmitic acid triglyceride and palmitoleic acid triglyceride are particularly preferable. preferable.

Component (F) glyceride comprises
0.1 to 25% by weight.
It is preferable to mix in a range of 0% by weight.

The squalane of the component (G) contains,
0.1 to 10% by weight, particularly 0.5 to 10% by weight.
It is preferable to mix in a range of 5% by weight.

In the present invention, the compound (H) generated from the component (A) or the component (E) means an amino acid decomposition product such as volatile amines generated by decomposition of the amino acid by a microorganism or the like, and is particularly limited. Although not to be done, for example, pyrrolidine, agmatine, cadaverine,
Piperidine, isobutylamine, isoamylamine, phenethylamine and the like. Component (H) can be contained in the entire composition at 0.00001 to 5% by weight,
In particular, it is preferable to mix in the range of 0.0001 to 1% by weight.

The N- or S-compounds (I) other than the above-mentioned components (A) and (E), which are generated from proteins of the human body, are defined as amino acids (wherein the component (A) And (E) amino acids) and volatile amines generated by further decomposition of the amino acids, sulfides such as hydrogen sulfide, and protein degradation products such as indole, for example, indole, ammonia, trimethylamine, tryptamine, alanine , Tyramine, histamine, putrescine, hydrogen sulfide, methyl mercaptan and the like. Component (I) can be contained in the entire composition at 0.00001 to 5% by weight,
In particular, it is preferable to mix in the range of 0.0001 to 1% by weight.

The model scalp odor composition for evaluation of the present invention includes:
For the purpose of adjusting the delicate quality and concentration of the scalp odor, a linear or branched fatty acid ester having 2 to 24 carbon atoms can be blended in addition to the above components (A) to (I).

Such fatty acid esters include, for example, hexanyl laurate, heptanyl laurate, lauryl octanyl ester, lauryl nonanyl ester, hexanyl palmitate, heptanyl palmitate, octanyl palmitate, Nonamyl palmitate, hexanyl palmitoleate and the like can be mentioned. These are 0.001 to 0.001 when components (A) to (I) are 1 part by weight.
It can be contained at 10,000 parts by weight.

Further, a solvent can be added to the evaluation model scalp composition of the present invention for the purpose of adjusting the concentration of the scalp odor composition, which is used to reproduce the actual strength of the scalp odor. Is important. Such a solubilizing agent is not particularly limited as long as it does not affect the scalp odor, and ethanol, 3-methoxy-3-methylbutanol, dipropylene glycol, diethyl phthalate, liquid paraffin, and the like can be used. Preferably, ethanol, diethyl phthalate and 3-methoxy-3-methylbutanol are particularly preferred in view of viscosity and solubilization as a model for evaluation, and dipropylene glycol and diethyl phthalate are preferred in that they are almost odorless. These are 0.001 to 1 when components (A) to (I) are 1 part by weight.
It is preferable to mix 0000 parts by weight.

Since the scalp odor composition thus prepared is close to the actual scalp odor, it can be used to evaluate the masking or suppressing effect of the scalp odor accurately and simply. A substance having a masking action or an inhibitory action can be efficiently screened. Therefore, the scalp odor composition and evaluation method of the present invention,
It is useful for the development of odor masking agents, deodorant / suppression agents, and various hair cosmetics containing these agents.

The evaluation of the masking or suppressing effect of the scalp odor using the evaluation model scalp odor composition of the present invention is performed, for example, by adding a subject to the evaluation model scalp odor composition of the present invention,
It can be carried out by bringing the composition of the present invention into contact with a subject, smelling the smell, and comparing it with the smell of the scalp odor composition of the present invention. As a specific method, the cup method may be used, and the evaluation of the odor is preferably performed by a specialized panel of 1 to 20 persons, and is preferably evaluated in 2 to 7 levels, preferably in 3 to 5 levels.

[0026]

EXAMPLES Examples 1 to 3

A model scalp odor composition for evaluation having the composition shown in Table 1 was prepared according to a conventional method, and comprehensively evaluated based on the following evaluation methods. The results are shown in Table 1.

(Evaluation method) Room temperature 25 ° C., humidity 65% HR
In a room kept in the environment, 10 professional panelists (five men and women each) use a cup (4.5 cm in lower circular diameter, 6.5 cm in upper circular diameter, 9 cm in height; content of about 216 cm ³ ). In a state where the model scalp odor composition diluted to 1.5% for evaluation was sprayed once into this cup, the scalp odor at that time was evaluated according to the following criteria, and those having an average score of less than 3 points were evaluated. It was determined as a model scalp odor composition for use.

1: clearly felt as scalp odor 2: sufficiently recognized as scalp odor 3: slightly recognized as scalp odor 4: slightly difficult to recognize as scalp odor 5: distinctly different from scalp odor

[0030]

[Table 1]

[0031]

[Table 2]

[0032]

[Table 3]

As is clear from the results in Table 1, the products of the present invention (Examples 1 to 3) were all excellent as model scalp odor compositions for evaluation.

Example 4 The masking effect of the scalp odor was evaluated for the compounds and fragrance compositions shown in Table 2 based on the following evaluation methods. Table 2 also shows the results.

(Evaluation method) Room temperature 25 ° C., humidity 65% HR
In a room kept in the environment, 10 professional panelists (five men and women each) use a cup (4.5 cm in lower circular diameter, 6.5 cm in upper circular diameter, 9 cm in height; content of about 216 cm ³ ). In this cup, the model scalp odor composition of Example 1 was added.
Each fragrance composition (addition rate: 0.1% by weight) was sprayed once in a state of spraying once, and immediately thereafter, the masking effect was measured 30 minutes later, 1 hour later, and the next day. The evaluation was based on the following criteria.

1: Completely masked 2: Almost masked 3: Slight scalp odor 4: Scalp odor (slightly insufficient masking) 5: Clear scalp odor (insufficient masking)

[0037]

[Table 4]

[0038]

[Table 5]

[0039]

[Table 6]

Example 5 Shampoo compositions 1 to 3 having the compositions shown in Table 4 were evaluated for the effect of suppressing scalp odor based on the following evaluation method.
Table 4 also shows the results.

(Evaluation method) Room temperature 25 ° C., humidity 65% HR
In a room kept in the environment of the above, the model scalp odor composition of Example 1 was applied by 10 specialized panelists (5 men and women),
After spraying once on a maple (length 20 cm, about 20 g),
The shampoo composition shown in Table 4 prepared according to a conventional method was applied, washed with hair, rinsed, sufficiently wiped off with a towel, and air-dried. In this environment, immediately after rinsing, after towel drying (about 1 hour after hair washing), the presence or absence of scalp odor was evaluated according to the following criteria, and the average score was obtained.
The suppression effect was determined according to the following criteria.

(Evaluation criteria) 1: No scalp odor completely 2: Almost no scalp odor 3: Slight scalp odor 4: Scalp odor 5: Clear scalp odor

(Judgment criteria) ：: Very good suppression of scalp odor (above average point 1 or more and less than 2 points) 良好: Good suppression of scalp odor (above average point 2 or more and less than 3 points) △: Scalp odor Slightly inadequate suppression (average score of 3 or more 4
×: Inadequate suppression of scalp odor (above average score of 4 or more)

[0044]

[Table 7]

[0045]

By using the evaluation model scalp odor composition of the present invention, the effect of masking or suppressing scalp odor can be evaluated, and a substance having the effect can be screened accurately and efficiently. In addition, since a functional evaluation can be performed in parallel with the examination while sufficiently examining safety, efficient product development can be achieved.

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) C11B 9/00 C11B 9/00 VZ F term (Reference) 4H059 AA09 BA01 BA26 BA33 BA34 BA42 BA43 BA48 BA52 BB02 BB03 BB14 BB15 BB18 BB24 BB44 BB45 BB53 BB57 BC42 BC43 DA09

Claims (7)

[Claims] 1. The following components: (A), (B), (C) and (D); (A) proline or a proline-containing peptide, (B) squalene, (C) cholesterol or a derivative thereof, (D) At least one or more fatty acids having 2 to 24 carbon atoms;
A model scalp odor composition for evaluation, comprising: 2. The model scalp odor composition for evaluation according to claim 1, further comprising (E) at least one selected from leucine, phenylalanine, serine, threonine, citrulline, valine, lysine and arginine. 3. The evaluation model scalp odor composition according to claim 1, further comprising (F) glyceride. 4. The model scalp odor composition for evaluation according to claim 1, further comprising (G) squalane. 5. The evaluation model scalp odor composition according to any one of claims 1 to 4, further comprising a compound (H) generated from the component (A) or the component (E). 6. The method according to claim 1, further comprising the step of:
The model scalp odor composition for evaluation according to any one of claims 1 to 5, comprising a compound or an S compound (I) (however, excluding the components (A) and (E)). 7. A method for evaluating scalp odor masking or scalp odor suppression effect, comprising using the model scalp odor composition for evaluation according to any one of claims 1 to 6.