JP5756621B2 - Sebum model and method for evaluating the cleanability of hair cleaners - Google Patents

Description

  The present invention relates to a sebum model and a method for evaluating detergency of a hair cleaning agent. More specifically, the present invention relates to a sebum model useful for developing a hair cleaning agent suitable for a user with a sticky feeling on the head, particularly a middle-aged user, and a method for evaluating the cleaning property of the hair cleaning agent. About.

  In recent years, with an increasing awareness of cleanliness, an increasing number of people are concerned about the sticky feeling of their heads. In particular, a human head over 40 years old tends to have a strong sticky appearance. The stickiness of the head is generally considered to be caused by sebum and sweat secreted from the scalp.

  In order to remove sebum and sweat from the head and to suppress the secretion of sebum and sweat, cleaning agents for hair and the like are used. However, the conventional hair cleaner cannot sufficiently improve the stickiness of the head.

  Evaluation of sebum detergency with a hair cleaning agent is, for example, a method using a human head (hereinafter referred to as “human head method”), and measuring a change in weight before and after washing of a keratin cloth coated with artificial sebum. (For example, refer to Patent Documents 1 to 3).

  In the human head method, for example, sensory evaluation is performed with a monitor, and the cleanability of the subject's scalp is confirmed with a microscope after the scalp is cleaned. However, since these methods place a burden on the subject, they tend to lead to fluctuations in the physiological phenomenon of the subject and errors in the evaluation are likely to occur, and the time and cost when performing the evaluation. There is a disadvantage that it takes.

  In addition, since the weight change measurement method uses cottonseed oil, animal fat, etc. as artificial sebum, the state of human sebum cannot be sufficiently reproduced. There is a drawback that it is difficult to accurately evaluate.

  On the other hand, the present inventors utilize the relationship between sebum composition and age, the relationship between sebum composition and head stickiness, and the use of these relationships to reduce the head stickiness or At present, no document has been found that specifically describes a method for accurately evaluating the detergency of sebum that gives the head a sticky feeling with a simple operation.

JP 2005-154354 A JP 2007-161906 A JP 2007-282682 A

  The present invention has been made in view of the prior art, and is a sebum model capable of accurately evaluating the effect of reducing the stickiness of the head or the detergency with respect to the sebum that gives the head a stickiness by a simple operation. The purpose is to provide. It is another object of the present invention to provide a method for evaluating the cleaning properties of a hair cleaning agent that can accurately evaluate the cleaning properties of sebum that gives a sticky feeling to the head with a simple operation.

That is, the gist of the present invention is as follows.
(1) A sebum model for evaluating the effect of reducing the stickiness of the head or the detergency of sebum that gives the head to the stickiness, comprising triglycerides and fatty acids, and the mass ratio of triglycerides and fatty acids A sebum model, wherein (triglyceride / fatty acid) is 0.57 / 1 or more,
(2) The sebum model according to (1), comprising 20 to 55% by mass of triglyceride,
(3) The sebum model according to (1) or (2), wherein the triglyceride is a triglyceride having an acyl group having 7 to 26 carbon atoms,
(4) The sebum model according to (3), wherein the triglyceride is a mixture containing tristearin, tripalmitin, trimyristin and triolein,
(5) The sebum model according to (1) to (4), wherein the fatty acid is a saturated fatty acid or unsaturated fatty acid having 7 to 26 carbon atoms,
(6) The sebum model according to (5), wherein the fatty acid is a mixture containing myristic acid, palmitic acid, stearic acid, and oleic acid.
(7) A method for evaluating the detergency of a detergent for hair against sebum that gives the head a sticky feeling, wherein the sebum model according to any one of (1) to (6) is hair, artificial hair, or keratin fiber After the specimen applied to the base material is washed with a hair washing agent, the amount of lipid contained in the sebum model remaining on the subject is measured, and the amount of the hair washing agent is determined by the amount of the lipid. (8) The method for evaluating the cleaning properties of a scrub for hair, characterized in that the cleaning properties are evaluated, and (8) the sebum that gives the head a sticky feeling is the middle-aged human scalp sebum Concerning the method.

  The sebum model of the present invention has an excellent effect that the effect of reducing the stickiness of the head or the detergency of the sebum that gives the head to the stickiness can be accurately evaluated with a simple operation. In addition, according to the method for evaluating the cleaning properties of the hair cleaning agent of the present invention, there is an excellent effect that the cleaning properties for sebum that gives the head a sticky feeling can be accurately evaluated with a simple operation.

In Experimental example 2, it is a graph which shows the result of having investigated the relationship between the stickiness of appearance, and the content rate of the triglyceride in scalp sebum. In Experimental Example 3, it is a graph which shows the result of having investigated the relationship between the site | part of a scalp and the quantity of the triglyceride in a scalp. In Experimental example 3, it is a graph which shows the result of having investigated the relationship between the site | part of a scalp and the quantity of the fatty acid in a scalp. In Experimental Example 3, it is a graph which shows the result of having investigated the relationship between the site | part of a scalp and the content rate of the triglyceride in scalp sebum. In Experimental example 3, it is a graph which shows the result of having investigated the relationship between the site | part of a scalp and the content rate of the fatty acid in scalp sebum. In Test Example 1, it is a graph showing the results of examining the relationship between the type of component and the residual rate. In Experiment 4, it is a graph which shows the result of having investigated the relationship between the kind of sebum model, the kind of shampoo, and the residual rate of a triglyceride. In Experiment 5, it is a graph which shows the result of having investigated the relationship between the kind of sebum model, the kind of shampoo, and the residual rate of a triglyceride.

  The sebum model of the present invention is a sebum model for evaluating the effect of reducing the stickiness of the head or the detergency of the sebum that gives the head to the stickiness, and contains a triglyceride and a fatty acid. And the mass ratio (triglyceride / fatty acid) is 0.57 / 1 or more.

  The sebum model of the present invention contains triglyceride and fatty acid, and the mass ratio of triglyceride to fatty acid (triglyceride / fatty acid) is 0.57 / 1 or more. It can reproduce the stickiness of the head that is often seen in Therefore, the sebum model of the present invention is useful for the effect of reducing the stickiness of the head or the evaluation of detergency against sebum that gives the head a feeling of stickiness.

  In the present specification, the term “middle-aged” refers to those 35 years of age or older. The middle and old age is preferably 40 to 59 years old.

  Examples of the triglyceride include triglycerides having an acyl group having 7 to 26 carbon atoms. The carbon number of the acyl group is 7 or more, preferably 13 or more, more preferably 14 or more from the viewpoint of accurately reproducing the stickiness of the human head, and accurately reproduces the stickiness of the human head. Therefore, it is 26 or less, preferably 20 or less, more preferably 18 or less. From the viewpoint of accurately reproducing the stickiness of the human head, the trichrylide is preferably a mixture containing tristearin, tripalmitin, trimyristin, and triolein.

  Each content of tristearin, tripalmitin, trimyristin and triolein in the mixture is preferably set within a range in which the stickiness of the human head can be accurately reproduced. For example, the contents of tristearin, tripalmitin, trimyristin and triolein in the mixture are the contents of tristearin, tripalmitin, trimyristin and triolein in triglycerides contained in human sebum. It can set suitably so that it may become the same. Usually, the content of tristearin in the mixture is 1 to 13% by mass, the content of tripalmitin in the mixture is 19 to 44% by mass, and the content of trimyristin in the mixture is 9 to 52%. The content rate of triolein in the said mixture is 20-56 mass%.

  Examples of the fatty acid include saturated fatty acids having 7 to 26 carbon atoms and unsaturated fatty acids. The carbon number is preferably 7 or more, more preferably 13 or more, and even more preferably 14 or more, from the viewpoint of accurately reproducing the stickiness of the human head, and accurately reproduces the stickiness of the human head. In view of the above, it is preferably 26 or less, more preferably 20 or less, and still more preferably 18 or less. The fatty acid is preferably a mixture containing myristic acid, palmitic acid, stearic acid, and oleic acid from the viewpoint of accurately reproducing the stickiness of the human head.

  Each content of myristic acid, palmitic acid, stearic acid, and oleic acid in the mixture is preferably set within a range in which the stickiness of the human head can be accurately reproduced. For example, the contents of myristic acid, palmitic acid, stearic acid, and oleic acid in the mixture are the same as the contents of myristic acid, palmitic acid, stearic acid, and oleic acid in fatty acids contained in human sebum. Can be set to be Usually, the content of myristic acid in the mixture is 9 to 52% by mass, the content of palmitic acid in the mixture is 19 to 44% by mass, and the content of stearic acid in the mixture is 1 to 13%. It is preferable that the content rate of oleic acid in the said mixture is 20-56 mass%.

  The mass ratio of triglyceride to fatty acid (triglyceride / fatty acid) is 0.57 / 1 or more, preferably 0.68 / 1 or more, more preferably 0 from the viewpoint of accurately reproducing the stickiness of the human head. .81 / 1 or more. In addition, it is preferable to set the upper limit of the mass ratio of the triglyceride and the fatty acid within a range in which the stickiness of the human head can be accurately reproduced. Usually, the upper limit of the mass ratio of the triglyceride and the fatty acid is preferably 50/1 or less.

  The total content of triglycerides and fatty acids in the sebum model of the present invention is preferably 20% by mass or more, more preferably 40% by mass or more, from the viewpoint of accurately reproducing the stickiness of the human head. From the viewpoint of accurately reproducing the sticky feeling of the head, it is preferably 80% by mass or less, more preferably 60% by mass or less.

  The sebum model of the present invention may contain other components contained in human sebum. The sebum model of the present invention is a saturated hydrocarbon compound that is liquid at room temperature (25 ° C.) having 15 to 30 carbon atoms, squalene or squalane, wax ester, from the viewpoint of accurately reproducing the stickiness of the human head. It is preferable to contain cholesterol and ceramide.

  The number of carbon atoms of the liquid saturated hydrocarbon compound is preferably 8 or more, more preferably 15 or more, from the viewpoint of suppressing alteration of the sebum model due to volatilization, and the viewpoint of accurately reproducing the stickiness of the human head. Therefore, it is preferably 40 or less, more preferably 30 or less. Examples of the liquid saturated hydrocarbon compound include liquid paraffin, isoparaffin, eicosane and the like. The liquid saturated hydrocarbon compounds may be used alone or in admixture of two or more. Among these, liquid paraffin is preferable from the viewpoint of accurately reproducing the stickiness of the human head. The content of the liquid saturated hydrocarbon compound in the sebum model of the present invention is preferably set as appropriate as long as the stickiness of the human head can be accurately reproduced.

  The content of squalene or squalane in the sebum model of the present invention is preferably set as appropriate as long as the stickiness of the human head can be accurately reproduced.

  Examples of the wax ester include esters of saturated fatty acids having 7 to 26 carbon atoms or unsaturated fatty acids and alcohols having 7 to 26 carbon atoms. The wax ester is preferably a mixture containing hexadecyl palmitate, myristyl myristate and oleyl oleate from the viewpoint of accurately reproducing the stickiness of the human head. The content of the wax ester in the sebum model of the present invention is preferably set within a range in which the stickiness of the human head can be accurately reproduced.

  Each content of hexadecyl palmitate, myristyl myristate and oleyl oleate in the mixture is similar to each content of hexadecyl palmitate, myristyl myristate and oleyl oleate in the wax ester contained in human sebum. Can be set to Usually, the content of hexadecyl palmitate in the mixture is 20 to 57% by mass, the content of myristyl myristate in the mixture is 9 to 52% by mass, and the content of oleyl oleate in the mixture is It is preferable that it is 20-56 mass%.

  The cholesterol content in the sebum model of the present invention is preferably set within a range in which the stickiness of the human head can be accurately reproduced.

  The ceramide is preferably ceramide 2 from the viewpoint of accurately reproducing the stickiness of the human head. The content of the ceramide in the sebum model of the present invention is preferably set as appropriate within a range in which the stickiness of the human head can be accurately reproduced.

  The sebum model of the present invention may contain other components as long as the object of the present invention is not hindered. Examples of other components include components contained in sebum, components contained in sweat, and the like. Although it does not specifically limit as a component contained in the said sebum, For example, a cholesterol ester, a fatty acid monoglyceride, a fatty acid diglyceride etc. are mentioned. The component contained in the sweat is not particularly limited, and examples thereof include organic acids such as lactic acid and pyruvic acid, amino acids, inorganic salts, and water.

  The sebum model of the present invention can be obtained by blending triglyceride and fatty acid so that the mass ratio of triglyceride to fatty acid (triglyceride / fatty acid) is 0.57 / 1 or more.

  As described above, since the sebum model of the present invention can accurately reproduce the stickiness of the human head, the effect of reducing the stickiness of the head or the detergency to sebum that gives the head a feeling of stickiness. Useful for evaluating Therefore, using the sebum model of the present invention, it is possible to evaluate the detergency of the hair cleaning agent for sebum that gives a sticky feeling to the head.

  The method for evaluating the cleaning property of the hair cleaning agent of the present invention is a method for evaluating the cleaning property of the hair cleaning agent for sebum that gives a sticky feeling to the head, and the sebum model of the present invention is hair, artificial hair or keratin fiber. After the specimen applied to the substrate is washed with a hair washing agent, the amount of lipid contained in the sebum model remaining on the subject is measured, and the hair washing agent is washed according to the amount of the lipid. It is a method characterized by evaluating sex.

  The method for evaluating the cleaning properties of the hair cleaning agent of the present invention is one major point in that the sebum model of the present invention is used to evaluate the cleaning properties of the hair cleaning agent for the sebum that gives the head a sticky feeling. There are features. According to the method for evaluating the cleaning properties of the hair cleaner of the present invention, the stickiness of the human head can be accurately reproduced by the sebum model. Accurate evaluation can be performed with a simple operation.

  In the present specification, the concept of the hair cleaning agent includes a liquid containing a substance to be examined for the presence or absence of detergency.

  The subject is obtained by applying the sebum model of the present invention to hair, artificial hair, or a keratin fiber substrate. Examples of the hair include hair obtained from humans. Examples of the artificial hair include artificial hair made of modacrylic fibers used for wigs and the like. Examples of the keratin fiber substrate include a cloth made of keratin (hereinafter also referred to as “keratin cloth”).

  The cleaning of the subject with the hair cleaning agent is performed, for example, by immersing the subject in the hair cleaning agent, wiping the subject with a cloth impregnated with the hair cleaning agent, or the like. It can be carried out, for example, by swallowing after directly applying to the skin.

  The lipid contained in the sebum model remaining on the subject can be recovered, for example, by extracting the lipid contained in the sebum model with an extraction solvent. Here, the lipid refers to a lipid component (for example, triglyceride, fatty acid, squalene or squalane, wax ester, etc.) contained in the sebum model of the present invention. The extraction solvent is not particularly limited, and examples thereof include chloroform, methanol, ethanol, propanol, butanol, hexane, dimethyl ether, acetone, and tetrahydrofuran.

  The method for measuring the amount of lipid is not particularly limited, but in the present invention, gas chromatography with a flame ionization detector (hereinafter referred to as “GC-FID”) can be used.

  In the method for evaluating the cleanability of the hair cleaner of the present invention, for example, the change in the amount of lipid on the subject before and after washing with the hair cleaner or the lipid on the subject after washing with the hair cleaner The detergency of the hair cleaning agent can be evaluated on the basis of the residual ratio. Here, when the amount of lipid on the subject after washing with the hair washing agent is smaller than the amount of lipid on the subject before washing with the hair washing agent, the hair washing agent Can be judged to have good detergency against sebum that gives the head a sticky feeling.

  In the method for evaluating the cleaning property of the hair cleaning agent of the present invention, the cleaning property (the level of cleaning power) against sebum that gives the head a sticky feeling can also be evaluated based on the residual rate of the lipid. In this case, it can be determined that the lower the residual rate, the higher the cleaning performance for sebum that gives the head a sticky feeling.

  As described above, according to the method for evaluating the cleaning property of the hair cleaning agent of the present invention, it is possible to accurately evaluate the cleaning property for sebum that gives the head a sticky feeling with a simple operation. Therefore, the method for evaluating the cleanability of the hair cleanser of the present invention is useful when developing a hair cleanser suitable for a user who has a sticky feeling on the head, particularly a middle-aged user. Further, in the method for evaluating the cleaning properties of the hair cleaner of the present invention, by using the sebum model, it is possible to accurately reproduce the stickiness of a human head without using a human head, The detergency of the hair detergent for sebum can be evaluated by a simple operation.

  Next, the present invention will be described in more detail based on examples. However, the present invention is not limited to the examples.

(Experimental example 1)
The subjects (10 men in their 40s and 50s and 16 men in their 20s) each hair and scalp were washed with unscented shampoo. At the end of 24 hours from the end of washing, a surface area of 540 mm ^{2 on} the surface of the subject's scalp was wiped off using absorbent cotton impregnated with the hexane-ethanol solution [hexane: ethanol (volume ratio) = 60: 40]. Next, scalp sebum adsorbed on the absorbent cotton was extracted using the hexane-ethanol solution. Thereafter, the obtained extract was concentrated and dried to obtain scalp sebum.

  10 μg of the obtained scalp sebum was dissolved in 1 μL of a chloroform-hexane solution [chloroform: hexane (volume ratio) = 2: 1] to obtain a sample. The obtained sample was spread on a high performance thin layer chromatography plate (hereinafter referred to as “HPTLC plate”) and developed with a developing solvent [chloroform: methanol: water (volume ratio) = 95: 20: 1]. Further, the mixture was developed with a developing solvent [hexane: diethyl ether: glacial acetic acid (volume ratio) = 80: 20: 10] to separate lipids constituting the scalp sebum.

  Then, 10 mass% copper sulfate aqueous solution was sprayed uniformly on the HPTLC plate. Next, the HPTLC plate was heated to 180 ° C. to develop color on the lipid on the HPTLC plate. The concentration and area of the spot corresponding to the obtained lipid were analyzed with a densitometer. The amount (mass) of each lipid was calculated based on the analysis result by a densitometer and a calibration curve prepared using a mixed standard solution of a known standard amount of lipid. As standard lipids, saturated hydrocarbon compounds that are liquid at normal temperature (25 ° C.) having 15 to 30 carbon atoms (manufactured by Wako Pure Chemical Industries, Ltd., trade name: Eicosan), squalene [Wako Pure Chemical Industries, Ltd. ), Trade name: squalene], wax ester [manufactured by Wako Pure Chemical Industries, Ltd., trade name: hexadecyl palmitate], triglyceride [manufactured by Sigma-Aldrich Japan, trade name: triolein], fatty acid [ Tokyo Chemical Industry Co., Ltd., trade name: oleic acid, ceramide [manufactured by Cayman, trade name: C-2 ceramide], cholesterol [manufactured by Wako Pure Chemical Industries, Ltd., trade name: cholesterol] were used.

  The average value (mass) of each lipid contained in the scalp sebum of each subject and the average value (mass) of each lipid contained in the scalp sebum of 16 male subjects in the twenties. Was calculated. And the total content of the lipid isolate | separated on the HPTLC plate was set to 100, and the content rate of each lipid was calculated | required. Moreover, the mass ratio (triglyceride / fatty acid) of triglyceride and fatty acid in each of the scalp sebum of men in their 40s and 50s and in the scalp of men in their 20s was calculated.

  As a result, the composition of scalp sebum in men in their 40s and 50s and the composition of scalp sebum in men in their 20s are that the content of triglycerides in the scalp of men in their 40s and 50s is in their 20s. Of fatty acids in scalp sebum of men in their 20s, with a tendency to be higher than the content of triglycerides in men's scalp sebum and the content of fatty acids in scalp sebum of men in their 40s to 50s It was found that there was a significant difference in the tendency to be less than the rate.

(Experimental example 2)
Four panelists evaluated the visual stickiness of the heads of subjects used in Experimental Example 1 (10 men in their 40s and 50s and 16 men in their 20s). The evaluation criteria for the visual stickiness are as follows.
〔Evaluation criteria〕
5 points: sticky 4 points: slightly sticky 3 points: normal 2 points: not sticky 1 point: not sticky at all

  Next, the relationship between the visual stickiness and the triglyceride content in the scalp sebum calculated in Experimental Example 1 was examined.

  In Experimental Example 2, the result of examining the relationship between the appearance of stickiness and the content of triglyceride in scalp sebum is shown in FIG. In FIG. 1, black triangles indicate men in their 40s and 50s, and white circles indicate men in their 20s.

  From the results shown in FIG. 1, it can be seen that the greater the content of triglyceride in the scalp sebum, the greater the visual stickiness. In addition, from the results shown in FIG. 1, compared with males in their 20s, males in their 40s and 50s tend to have a higher content of triglycerides in scalp sebum and a greater visual stickiness. I understand.

(Experimental example 3)
In Experimental Example 1, except that scalp sebum was collected from the frontal, parietal, occipital, or temporal regions of each subject (10 men in their 40s and 50s and 16 men in their 20s) The same operation as in Experimental Example 1 was performed, and the amount (mass) of each lipid was calculated. The average value of triglyceride per cm ² of scalp in men in their 40s and 50s, the average value of fatty acid per cm ² of scalp in men in their 40s and 50s, per cm ² of scalp in men in their 20s The average value of the amount of triglyceride and the average value of the amount of fatty acid per 1 cm ² of scalp of males in their 20s were calculated. In addition, the total mass of lipids separated on the HPTLC plate is defined as 100, the content of triglyceride in the scalp sebum of men in their 40s and 50s, the content of fatty acid in the scalp of men in their 40s and 50s The content of triglyceride in scalp sebum of men in their 20s and the content of fatty acid in scalp sebum of men in their 20s were calculated.

  In Experimental Example 3, the results of examining the relationship between the scalp site and the amount of triglyceride in the scalp are shown in FIG. FIG. 3 shows the results of examining the relationship between the scalp site and the amount of fatty acid in the scalp in Experimental Example 3. FIG. 4 shows the results of examining the relationship between the scalp site and the triglyceride content in the scalp sebum in Experimental Example 3. FIG. 5 shows the results of examining the relationship between the scalp site and the fatty acid content in the scalp sebum in Experimental Example 3. In FIG. 2, the white bar shows the amount of triglyceride in the scalp of men in their 20s and the black bar shows the amount of triglyceride in the scalp of men in their 40s and 50s. In FIG. 3, the white bar indicates the amount of fatty acid in the scalp of men in their 20s, and the black bar indicates the amount of fatty acid in the scalp of men in their 40s and 50s. In FIG. 4, the white bar indicates the content of triglyceride in scalp sebum of men in their 20s, and the black bar indicates the content of triglyceride in scalp sebum of men in their 40s to 50s. In FIG. 5, the white bars indicate the fatty acid content in scalp sebum of men in their 20s and the black bar indicates the fatty acid content in scalp sebum of men in their 40s and 50s.

  From the results shown in FIGS. 2 and 3, men in their 40s to 50s compared to men in their 20s in the scalp at any part of the frontal, parietal, occipital, and temporal regions. It can be seen that the amount of triglyceride tends to be large and the amount of fatty acid in the scalp tends to be small. From the results shown in FIG. 4 and FIG. 5, men in their 40s to 50s compared to men in their 20s in any part of the frontal region, the parietal region, the occipital region, and the temporal region. It can be seen that the content of triglyceride in scalp sebum is high and the content of fatty acid in scalp sebum tends to be low.

(Example 1 and Comparative Example 1)
A hydrocarbon compound, squalene, wax ester, triglyceride, fatty acid, cholesterol, and ceramide are blended so as to have the composition shown in Table 1, and the triglyceride / fatty acid (mass ratio) is 0.81. A sebum model of 1 was prepared (Example 1). The sebum model obtained in Example 1 is a model of scalp sebum that tends to give the head a sticky appearance and is often found in men in their 40s to 50s.

  Also, a hydrocarbon compound, squalene, wax ester, triglyceride, fatty acid, cholesterol, and ceramide are blended so as to have the composition shown in Table 1, and the triglyceride / fatty acid (mass ratio) is 0. A sebum model (Comparative Example 1) that was .34 / 1 was prepared. The sebum model obtained in Comparative Example 1 is a model of scalp sebum that tends not to give the head a sticky appearance and is often found in men in their 20s.

  As the hydrocarbon compound, liquid paraffin (manufactured by Sonneborn Inc., trade name: KAYDOL), which is a saturated hydrocarbon compound that is liquid at room temperature (25 ° C.), was used. Further, as the squalene, Wako Pure Chemical Industries, Ltd., trade name: squalene was used. As the wax ester, hexadecyl palmitate [manufactured by Wako Pure Chemical Industries, Ltd., trade name: hexadecyl palmitate], myristyl myristate [manufactured by Kao Corporation, trade name: EXCEPARL MY-M] and oleic oleate [COGNIS] A product [trade name: CETIOL, manufactured by Japan Co., Ltd.] [hexadecyl palmitate: myristyl myristate: oleyl oleate (mass ratio) = 7: 2: 5] was used. As the triglycerides, tristearin [manufactured by Nacalai Tesque Co., Ltd., trade name: Tristearin] and tripalmitin [manufactured by Wako Pure Chemical Industries, Ltd., trade name: tripalmitin] and trimyristin [Wako Pure Chemical Industries, Ltd.] Product, trade name: trimyristin] and triolein [manufactured by Wako Pure Chemical Industries, Ltd., trade name: triolein] [Tristearin: tripalmitin: trimyristin: triolein (mass ratio) = 1: 8 : 3: 9] was used. As the fatty acid, myristic acid [manufactured by Nacalai Tesque Co., Ltd., trade name: myristic acid] and palmitic acid [manufactured by Nacalai Tesque Co., Ltd., trade name: palmitic acid] and stearic acid [manufactured by Wako Pure Chemical Industries, Ltd., Product name: stearic acid] and oleic acid [made by Wako Pure Chemical Industries, Ltd., product name: oleic acid] [myristic acid: palmitic acid: stearic acid: oleic acid (mass ratio) = 4: 10: 2 : 10] was used. As the cholesterol, Wako Pure Chemical Industries, Ltd., trade name: cholesterol was used. As the ceramide, Ceramide 2 [(2S, 3R) -2-octadecanoylaminooctadecane-1,3-diol, manufactured by Takasago International Corporation, trade name: Ceramide TIC-001] was used.

(Test Example 1)
A commercially available shampoo was dissolved in purified water to a concentration of 7% by mass to obtain an aqueous shampoo solution.

  The sebum model obtained in Example 1 or Comparative Example 1 was heated to 60 ° C. and liquefied. 0.25 g of the obtained sebum model was uniformly applied to a keratin cloth (20 mm × 20 mm). The keratin cloth after application of the sebum model was allowed to stand at 35 ° C. for 12 hours or more.

Next, the keratin cloth after application of the sebum model was placed in a container containing 100 mL of the aqueous shampoo solution whose liquid temperature was maintained at 45 ° C. The keratin cloth after application of the sebum model was washed by shaking the container for 60 minutes so that the vibration frequency was 60 min ⁻¹ and the amplitude was 15 mm.

  The sebum model remaining on the washed keratin cloth was extracted with chloroform. The obtained extract was subjected to GC-FID, and a peak area (hereinafter referred to as “area A”) corresponding to a component (fatty acid, squalene, wax ester or triglyceride) contained in the sebum model was obtained. Further, except that a sebum model attached to the keratin cloth before washing was used instead of the sebum model remaining on the washed keratin cloth, the same operation as described above was performed, and the peak area corresponding to the component (hereinafter referred to as the sebum model) , “Area B”). Next, the residual ratio [(area A / area B) × 100] of the lipid was calculated. FIG. 6 shows the results of examining the relationship between the type of component and the residual rate in Test Example 1. In FIG. 6, the white bar indicates the residual ratio of the component when the sebum model obtained in Example 1 is used, and the black bar indicates the residual ratio of the component when the sebum model obtained in Comparative Example 1 is used.

  From the results shown in FIG. 6, the residual ratio of the component when using the sebum model obtained in Example 1 is compared with the residual ratio of the component when using the sebum model obtained in Comparative Example 1. I understand that it is expensive. From these results, it can be seen that the sebum model obtained in Example 1 cannot be sufficiently washed with the commercially available shampoo. Therefore, this result suggests that scalp sebum of men in their 40s to 50s cannot be sufficiently washed with the commercially available shampoo.

(Test Example 2)
The sebum model obtained in Example 1 and the sebum model obtained in Comparative Example 1 were used to verify whether a sticky feeling of the head was generated.

  Wig [Product name: Natural Hair No. One side of Y-600 Eucalyptus] was coated with 0.5 g of the sebum model obtained in Example 1. Moreover, the sebum model 0.5g obtained by the comparative example 1 was apply | coated to the other half head. Next, the wig was allowed to stand for 24 hours in a laboratory maintained at a relative humidity of 60% and a temperature of 23 ° C.

  After that, it was judged whether 20 half-heads of panelists applied the sebum model obtained in Example 1 or the half heads applied the sebum model obtained in Comparative Example 1 had a sticky feeling of appearance or touch. The sticky feeling was evaluated. Moreover, let 21 panelists determine which half head which applied the sebum model obtained in Example 1 and the half head which applied the sebum model obtained in Comparative Example 1 feels the sticky feeling of tactile sensation. Thus, the sticky feeling of the tactile sensation was evaluated. Table 2 shows the results of evaluating the stickiness of appearance and the stickiness of touch.

  From the results shown in Table 2, the number of panelists who feel the stickiness of appearance and the feeling of stickiness on the half-head coated with the sebum model obtained in Example 1 is the sebum model obtained in Comparative Example 1. It can be seen that there is a tendency to be larger than the number of panelists who feel the stickiness of the appearance and the touch of the touch on the half head. Therefore, it can be seen from these results that the sebum model obtained in Example 1 can be used as a scalp sebum that gives the head a sticky feeling. Further, from the results of Test Example 1 and Test Example 2, according to the sebum model obtained in Example 1, the stickiness of the head similar to that often seen in men in their 40s and 50s, and this stickiness This suggests that it is possible to reproduce the difficulty in cleaning scalp sebum that gives a feeling.

(Test Example 3)
(1) Preparation of sebum model A sebum model was obtained by blending a hydrocarbon compound, squalene, wax ester, triglyceride, fatty acid, cholesterol and ceramide so as to have the composition shown in Table 3. The hydrocarbon compound, squalene, wax ester, triglyceride, fatty acid, cholesterol and ceramide are the same as the hydrocarbon compound, squalene, wax ester, triglyceride, fatty acid, cholesterol and ceramide used in Example 1.

(2) Evaluation of visual stickiness and stickiness of tactile sensation 0.5 g of a sebum model of test number 1 was applied to one half of the wig. Next, the wig was allowed to stand for 24 hours in a laboratory maintained at a relative humidity of 60% and a temperature of 23 ° C.

  After that, five panelists evaluated the visual stickiness by comparing the sticky feeling on the half head with the sebum model applied with the sticky feeling on the half head with no sebum model applied. .

  In addition, five panelists evaluated the sticky feeling of the tactile sensation by comparing the sticky feeling of the tactile sensation in the half head with the sebum model applied with the sticky feeling of the tactile sensation in the half head not applied with the sebum model. I did it.

The evaluation of the stickiness of appearance or touch is as follows.
〔Evaluation criteria〕
5 points: sticky 4 points: slightly sticky 3 points: normal 2 points: not sticky 1 point: not sticky at all

  Further, except that the sebum model of any of test numbers 2 to 8 was used instead of the sebum model of test number 1, the same operation as described above was performed, and the visual stickiness and tactile feel were evaluated. It was.

  Table 3 shows the results of evaluating the sticky feeling of appearance and the sticky feeling of tactile sensation in Test Example 3. In addition, in the evaluation results of the sticky feeling of the appearance and the tactile feeling in the table, “A” is a total score of 20 to 25 points by five panelists, and “B” is five panelists. The total score of evaluation by 15 to 19 points, “C” is the total score of evaluation by 5 panelists is 10 to 14 points, “D” is the total score of 5 panelists evaluation is 5 to 5 points Indicates 9 points.

(3) Evaluation of triglyceride persistence From the results shown in FIG. 6, when the sebum model obtained in Example 1 and the sebum model obtained in Comparative Example 1 were used, the sebum model obtained in Example 1 was used. Among the differences between the residual ratios of the components, the residual ratio of triglycerides when using the sebum model obtained in Example 1 and the residual ratio of triglycerides when using the sebum model obtained in Comparative Example 1 It can be seen that the difference is the largest. Therefore, in the scalp sebum, the increase in the content of triglyceride is considered to be one cause of the stickiness of the head and the difficulty of cleaning the scalp sebum that gives this stickiness.

  Then, as evaluation of the usefulness of a sebum model, the residual property of triglyceride was investigated as follows.

  First, in Test Example 1, the same operation as in Test Example 1 was performed except that any of the sebum models of Test Nos. 1 to 8 was used instead of the sebum model obtained in Example 1 or Comparative Example 1. The residual ratio of triglyceride was calculated. And the residual property of triglyceride was evaluated by the following evaluation criteria. Table 3 shows the results of evaluation of triglyceride persistence in Test Example 3. In the evaluation results of triglyceride persistence in the table, “A” is a residual rate of 100 to 75%, “B” is a residual rate of 74 to 50%, and “C” is a residual rate. Is 49 to 25%, and "D" indicates that the residual ratio is 24 to 0%.

  From the results shown in Table 3, when the sebum models of test numbers 3 to 8 were used, the apparent stickiness was “B” or “A”, the tactile stickiness was “B” or “A”, and the triglyceride It can be seen that the persistence is “B” or “A”. Therefore, in a sebum model containing a hydrocarbon compound, squalene, wax ester, triglyceride, fatty acid, cholesterol and ceramide, the triglyceride / fatty acid (mass ratio) is 0.57 / 1 or more, so It is suggested that the stickiness of the head similar to that often seen in men and the difficulty of cleaning scalp sebum that gives this stickiness can be reproduced.

(Test Example 4)
In Test Example 1, the same operation as in Test Example 1 was performed except that a commercially available shampoo (shampoo A, shampoo B, or shampoo C) was used instead of the unscented shampoo, and the residual ratio of triglyceride was calculated. FIG. 7 shows the results of examining the relationship between the type of sebum model, the type of shampoo, and the residual ratio of triglycerides in Test Example 4.

  From the results shown in FIG. 7, when the sebum model obtained in Example 1 is used, it can be seen that the commercially available shampoo A has a lower residual ratio of triglycerides than the commercially available shampoo B and shampoo C. From these results, since the commercially available shampoo A is superior to the commercially available shampoos B and C in terms of detergency for the sebum model obtained in Example 1, scalp sebum that gives the head a sticky feeling, particularly 40-50. It is suggested that the scalp sebum, which is often found in men of the age group, is excellent in cleansing properties.

  On the other hand, when the sebum model obtained in Comparative Example 1 was used, the commercially available shampoo A had a higher triglyceride residual ratio than the commercially available shampoos B and C, and the sebum model obtained in Comparative Example 1 was compared with the sebum model. It can be seen that the detergency is low. From this result, in the sebum model obtained in Comparative Example 1, it is possible to accurately evaluate the detergency against scalp sebum that gives a sticky feeling of the head, particularly scalp sebum frequently seen in men in their 40s and 50s. I understand that I can't.

  Therefore, by using the sebum model obtained in Example 1, to evaluate the detergency of shampoo and the like for scalp sebum that gives the same stickiness to the head as is often seen in men in their 40s and 50s. You can see that

(Production Example 1)
25 g of an anionic surfactant (manufactured by Shin Nippon Rika Co., Ltd., trade name: Rica Mild ES-100, 30% by mass disodium lauryl polyoxyethylene sulfosuccinate) in 125 g of purified water, and 5% by mass of the surfactant The contained pseudo shampoo composition (shampoo D) was obtained.

(Production Example 2)
A pseudo shampoo composition containing 25 g of an amphoteric surfactant (trade name: Anhitol 20HD, 30% by mass lauryl hydroxysulfobetaine) manufactured by Kao Corporation and dissolved in 125 g of purified water (5% by mass). Shampoo E) was obtained.

(Test Example 5)
In Test Example 1, the same procedure as in Test Example 1 was carried out except that the shampoo D obtained in Production Example 1 or the shampoo E obtained in Production Example 2 was used instead of the unscented shampoo, and the remaining triglyceride remained. The rate was calculated. FIG. 8 shows the results of examining the relationship between the type of sebum model, the type of shampoo, and the residual ratio of triglycerides in Test Example 5.

  From the results shown in FIG. 8, it can be seen that when the sebum model obtained in Example 1 is used, there is a difference between the residual ratios of triglycerides after washing with shampoo D and shampoo E, respectively. Therefore, by using the sebum model obtained in Example 1, scalp sebum that gives the head a sticky feeling, in particular, the magnitude of detergency such as shampoo for scalp sebum frequently seen in men in their 40s and 50s. It can be seen that can be evaluated. On the other hand, when the sebum model obtained in Comparative Example 1 is used, since the triglyceride hardly remains after washing with shampoo D and shampoo E, the magnitude of the detergency is evaluated. It turns out that it is not suitable for.

  As explained above, by using a sebum model containing a hydrocarbon compound, squalene, a wax ester, a triglyceride, a fatty acid, cholesterol and ceramide and having a triglyceride / fatty acid (mass ratio) of 0.57 / 1 or more, It can be seen that the stickiness of the human head can be accurately reproduced. Therefore, according to the above-mentioned sebum model, it can be seen that the cleansing ability of the hair cleaner can be accurately evaluated for sebum that gives a sticky feeling, particularly sebum frequently found in men in their 40s and 50s. In addition, by using the sebum model, it is possible to accurately reproduce the stickiness of the human head without using a human head. You can see that you can.

Claims (7)

A sebaceous model used in the cleaning of the evaluation for the sebum which gives the sticky feeling in reduction or head of sticky feeling of the head, containing a triglyceride and a fatty acid, the weight ratio of triglyceride and fatty acid (triglyceride / fatty acid) is Ri der 0.57 / 1 or more, sebaceous model the triglyceride is tristearin, tripalmitin, wherein mixture der Rukoto containing trimyristin and triolein.   The sebum model according to claim 1, comprising 20 to 55% by mass of triglyceride. The content of tristearin in the mixture is 1 to 13% by mass, the content of tripalmitin in the mixture is 19 to 44% by mass, the content of trimyristin in the mixture is 9 to 52% by mass, the mixture The sebum model according to claim 1 or 2, wherein the content of triolein is 20 to 56 mass% . Before SL fatty acids sebum model according to any one of claims 1 to 3, which is a saturated fatty acid or unsaturated fatty acid 7 to 26 carbon atoms. The sebum model according to claim 4 , wherein the fatty acid is a mixture containing myristic acid, palmitic acid, stearic acid, and oleic acid. A method for evaluating the washability of a hair detergent for sebum that gives a sticky feeling to the head, wherein the sebum model according to any one of claims 1 to 5 is applied to hair, artificial hair, or a keratin fiber substrate. After the subject is washed with a hair washing agent, the amount of lipid contained in the sebum model remaining on the subject is measured, and the detergency of the hair washing agent is evaluated by the amount of the lipid. A method for evaluating the detergency of a hair cleanser. The method according to claim 6 , wherein the sebum that gives a sticky feeling to the head is middle-aged human scalp sebum.