CN1745779A - Chinese medicine for treating angiitis and phlebitis etc. thromboembolia disease - Google Patents

Abstract

A Chinese medicine in the form of ointment for treating vasculitis, phlebitis, phlebeurysma, peripheral neurtitis, pile, burn, scald, etc is prepared from 7 Chinese-medicinal materials including dahurian angelica root, pollen, red peony root, red sage root, etc through grinding and mixing the powder with vaseline.

Description

A kind of Chinese medicine for the treatment of the inaccessible disease of thrombosis such as vasculitis, phlebitis

Technical field: the present invention relates to Chinese medicine, particularly the Chinese medicine of the inaccessible disease of thrombosis such as vasculitis, phlebitis, varicosis.

Background technology: be used for the treatment of vasculitis at present, phlebitis, varicosis, thunder Loews disease, the significant medicine that also is of no curative effect of diseases such as peripheral nerve inflammation, it is all very painful to suffer from this sick people, the patient who is in a bad way also needs amputation, done multiple effort in order to address this problem people, the plurality of Chinese prescription has been proposed, as Chinese patent: " 00129961; 1 " the technology that one key name is called " a kind of vasculitic medicated powder of treatment and preparation method " number is disclosed, this medicine has certain effect to alleviating lighter symptom, then be of no curative effect for the patient with severe symptoms, addressing this problem becomes urgent need.

The content of invention: overcome the deficiency that prior art exists, propose that a kind of therapeutic effect is splendid, short treating period, the Chinese medicine that can effect a radical cure diseases such as vasculitis, phlebitis, varicosis, thunder Loews disease, peripheral nerve inflammation that expense is low.This Chinese medicine is made of following composition: Radix Et Rhizoma Rhei, the Radix Angelicae Dahuricae, pollen, Radix Paeoniae Rubra, Pollen Typhae, Radix Salviae Miltiorrhizae, Olibanum; The weight proportion of its each composition is: the 10-20 of Radix Et Rhizoma Rhei part, Radix Angelicae Dahuricae 10-20 part, pollen 10-20 part, Radix Paeoniae Rubra 10-20 part, Pollen Typhae 10-20 part, Radix Salviae Miltiorrhizae 10-20 part, Olibanum 10-20 part.Its production technology is: Radix Et Rhizoma Rhei, the Radix Angelicae Dahuricae, pollen, Radix Paeoniae Rubra, Pollen Typhae, Radix Salviae Miltiorrhizae, Olibanum seven flavor medicine are ground to form 100 purpose smalls, and mix homogeneously adding vaseline is made ointment and is got final product.Chinese medicine of the present invention is owing to contain Radix Et Rhizoma Rhei, and the energy diuretic has the removing blood stasis and activating blood flow function, and subcutaneous tissue is discharged sepage, accelerates hypodermic recovery; Owing to contain pollen, have multivitamin and trace element, can remove the too much free radical of human body, keep cell activity and vigor, locate into metabolism; Contain the Radix Angelicae Dahuricae, have that cold expelling is sensible, an effect of wind-expelling pain-stopping, detumescence and apocenosis.Contain pollen, contain Radix Paeoniae Rubra, have the effect of clearing away heat and cooling blood, stasis-dispelling and pain-killing.Contain Pollen Typhae, the effect of have hemostasis, invigorating blood circulation.Contain Radix Salviae Miltiorrhizae, have the effect of blood circulation promoting and blood stasis dispelling, removing heat from blood eliminating carbuncle.Contain Olibanum, have the effect of promoting blood circulation and stopping pain, granulation promoting.The result of above-mentioned every medicine comprehensive function makes Chinese medicine of the present invention have blood circulation promoting and blood stasis dispelling, dredge the meridian passage, puies forward the function of analgesic, the anti-inflammatory analgesic of poison, removing the necrotic tissue and promoting granulation, and disease effects such as treatment vasculitis, phlebitis, varicosis are splendid, short treating period, expense are low.

The specific embodiment: get the 10g of Radix Et Rhizoma Rhei, Radix Angelicae Dahuricae 10g, pollen 10g, Radix Paeoniae Rubra 10g, Pollen Typhae 10g, Radix Salviae Miltiorrhizae 10g, Olibanum 20g, grind to form 100 purpose smalls, mix homogeneously adds vaseline and makes ointment promptly.

Get the 20g of Radix Et Rhizoma Rhei, Radix Angelicae Dahuricae 20g, pollen 20g, Radix Paeoniae Rubra 20g, Pollen Typhae 20g, Radix Salviae Miltiorrhizae 20g, Olibanum 10g, grind to form 100 purpose smalls, mix homogeneously adds vaseline and makes ointment promptly.

Using method: medicine for external use is applied to the illing skin surface, a 4g, 1 time on the one.

In order to estimate the clinical medicine safety of Chinese medicine of the present invention, it has been carried out toxicity test research, be reported as follows:

1. be subjected to test product: a kind of Chinese medicine every day for the treatment of the inaccessible diseases of thrombosis such as vasculitis, phlebitis 1 time, each 4 grams.

2. experimental animal: the white mice of Kunming kind, body weight 18-22 gram, male and female dual-purpose.

3. the preparation of dosage and test drug: get a kind of Chinese medicine 4 grams for the treatment of the inaccessible diseases of thrombosis such as vasculitis, phlebitis, put and add the 10.0ml distilled water in the mortar and be uniformly dispersed, make solution.Administering mode is a gastric infusion.

One, the mensuration of median lethal dose(LD 50)

Get 9 of mices, divide three groups, but fail to find out the dosage of 100% animal dead.

Select 50 of the healthy mices of body weight 20 ± 2g for use, male and female half and half are divided into five groups at random, an oral administration gavage administration, and dosage is by geometric progression, and maximum dose level calculates with the maximum volume that can accept.Observed 7 days none death as a result after the administration.

Two, mtd test

Select 20 of healthy mices, male and female half and half, normally raise 1 after, administration is 1 time in 24 hours, observes continuously 7, does not see untoward reaction and death condition, can think the oral avirulence of this medicine.The maximum tolerated dose multiple is calculated as follows:

$=\frac{0.8\×3\×24\%}{20}\×\frac{60000}{6\×3\×0.4}$

If use every day by the adult; Consumption 4 grams calculate, and the result is 240 times of normal clinical dosage, illustrate that a kind of Chinese medicine for the treatment of the inaccessible disease of thrombosis such as vasculitis, phlebitis has safety.

A kind of Chinese medicine clinical summary for the treatment of the inaccessible disease of thrombosis such as vasculitis, phlebitis

One group to the statistics in the patients clinical observations of diseases such as vasculitis, phlebitis, varicosis this organizes 5% case for observing the patient of treatment.Man's 43 examples wherein, women 16 examples, age 40-50 year 10 examples, 51-60 year 30 examples, 19 examples more than 61 years old, wherein Therapeutic Method is the patient to be divided into two groups at random, 39 examples are organized in treatment, use Chinese medicine of the present invention, every day 1 time, each 4 grams, 30 days is a course of treatment.Matched group 20 examples are taken other medicine, and 30 days is a course of treatment, all do inspection before and after the treatment, and the result shows that the treatment group effective percentage of taking Chinese medicine of the present invention is 98%, and matched group does not have obvious effects.

Claims (2)

1, a kind of Chinese medicine for the treatment of the inaccessible disease of thrombosis such as vasculitis, phlebitis is characterized in that this Chinese medicine is made of following composition: Radix Et Rhizoma Rhei, the Radix Angelicae Dahuricae, pollen, Radix Paeoniae Rubra, Pollen Typhae, Radix Salviae Miltiorrhizae, Olibanum; The weight proportion of its each composition is: the 10-20 of Radix Et Rhizoma Rhei part, Radix Angelicae Dahuricae 10-20 part, pollen 10-20 part, Radix Paeoniae Rubra 10-20 part, Pollen Typhae 10-20 part, Radix Salviae Miltiorrhizae 10-20 part, Olibanum 10-20 part.

2, the Chinese medicine of the inaccessible disease of thrombosis such as treatment vasculitis as claimed in claim 1, phlebitis, it is characterized in that its production technology is: Radix Et Rhizoma Rhei, the Radix Angelicae Dahuricae, pollen, Radix Paeoniae Rubra, Pollen Typhae, Radix Salviae Miltiorrhizae, Olibanum seven flavor medicine are ground to form 100 purpose smalls, and mix homogeneously adding vaseline is made ointment and is got final product.