CN103393918B - Compounded garcinia and radix angelicae ointment for preventing and treating chemotherapeutic phlebitis - Google Patents
Compounded garcinia and radix angelicae ointment for preventing and treating chemotherapeutic phlebitis Download PDFInfo
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Abstract
The invention relates to the technical field of medicine preparation, is a traditional Chinese medicine for preventing and treating chemotherapeutic phlebitis, and solves the problems that the existing medicines for treating the chemotherapeutic phlebitis has a poor effect, high price and the like. A compounded garcinia and radix angelicae ointment for preventing and treating chemotherapeutic phlebitis comprises the following medical components in parts by mass: 500-1000 parts of garcinia, 150-250 parts of radix angelicae, 1000-1500 parts of fritillary, 200-300 parts of rheum officinale, 200-300 parts of camphor, 200-300 parts of borneol, 100-300 parts of costus root and 100-300 parts of mint. According to the invention, the garcinia as a monarch drug is taken as a medicine prescription for treating the chemotherapeutic phlebitis, the treating methods of clearing heat and expelling damp, detoxicating and removing pus, relieving swelling and pain, activating blood and removing blood stasis and dredging main and collateral channels are used to prevent and treat the chemotherapeutic phlebitis.
Description
Technical field
The present invention relates to field of medicine preparing technology, there is the Chinese medicine for a kind of prevention and therapy chemotherapeutic phlebitis.
Background technology
Intravenous chemotherapy is the important means for the treatment of malignant tumor, uses widely clinically, but most chemotherapeutics has strong impulse effect to local, causes Superficial veins in various degree scorching.Bibliographical information vein instillation chemotherapeutics local phlebitis incidence rate can reach 84%, not only brings misery to patient, and affects carrying out as scheduled of chemotherapy.Therefore the control of chemotherapeutic phlebitis is very necessary.The prevention and controls of chemotherapeutic phlebitis is numerous, 1, the intravenous administration: (Guan Xuming such as Guan Xuming, Wang Yanjun, Chen little Yan. the clinical observation [J] of intravenous drip temperature solution prevention of phlebitis. Nursing graduate education, 2003, 17 (3): 277) introduce and before injection lid promise, first add dexamethasone 5mg with 100ml normal saline set up venous access, Gai Nuo is dissolved in 100ml saline to drip off in 30 minutes, middle with 0.9% normal saline flushing vein, add dexamethasone 5 ~ 10mg with 100ml normal saline immediately after medication slowly to instil washing pipe, then rinse with 0.9% normal saline 500 ~ 1000ml vein.Ikeda uses heparin sodium 5000u intravenous injection for first 3 hours in antitumor drug injection, phlebitis incidence rate is made to be reduced to 10%, and have no coagulation disorders (Ikeda S, Douchi T, Nagata Y.Use of heparin to lower the incidence ofPhlebitisinducedbyanti-neoplasticagentsusedinovarianca ncer [J] .J-Obstet-Gynaecol-Res. 2004,30 (6): 427-429).Although above method is effective, intravenous administration has certain side effect, also needs the indication grasping these medicines during use, therefore, there is limitation as control chemotherapeutic phlebitis.2, Western medicine partial smearing: Vilardell M etc. study and find to use heparin gel partial smearing can reduce incidence rate (the Vilardell M of thrombophlebitis, Sabat D, Arnaiz JA, Bleda MJ, Castel JM, Laporte JR, VallveC.Topical heparin for the treatment of acute superficial phlebitis secondarytoindwellingintravenouscatheter [J] .EurJClinPharmacol, 1999,54:917-921); Tian Tongrong applies four kinds of medicine partial smearing methods and studies it causes rabbit ear vein damage preventive effect to nvelbine, the infringement of discovery hyaluronidase (hyaluronidase) rabbit ear vein and surrounding tissue is afterwards all lighter, its protection effect be better than nitroglycerin, 2% scopolamine and 25% magnesium sulfate (Tian Tongrong. the experimentation that hyaluronidase prevention vinorelbine is phlebitis caused and clinical practice [J]. Chinese clinical tumor and rehabilitation, 2004,11 (3): 204-206).The clinical protective agents for chemotherapeutic phlebitis is of a great variety, but drug effect limitation is single, if heparin gel is only to reduction blood viscosity, anti-tampon, improve medicine microcirculation remarkable, though hyaluronidase has better prevention effects to phlebitis, but antibacterial and anastalsis unsatisfactory curative effect (Huo Chunnuan, Mao Yanling, appoint Jianping, paddy Qingyang. the experimentation [J] that Hepudiod Cream is treated dopamine induced intravenous rabbit and damaging surrounding tissue. Acad J PLA Postgrad Med Sch, 2000, 21 (4): 288-289), majority is cured the symptoms, not the disease, empirical medication is in the majority, the objective criterion of shortage science.3, partial closure: adopting 2% procaine 5ml to add dexamethasone 5mg when treating nvelbine venous injury, doing radial multi-point injection centered by affected part, drug application application causes remission simultaneously.Partial closure has certain curative effect to exsomose injury, but more or less brings new misery to patient, and patient is difficult to accept, and close opportunity and dosage, scope is wayward, more can not accomplish that the preventive measure for chemotherapeutic phlebitis is popularized.4, the external application of Chinese medicine: all little equality (Zhou little Ping, Miao Jingxia, Liao Rongrong, etc. the cool Prophylactic chemotherapy phlebitis [J] of a note. nursing journal, 2008,15(5): 10) by a note cool (main component: natural Herba Menthae) Prophylactic chemotherapy phlebitis 80 example, chemotherapeutic phlebitis incidence rate 0 grade of 66 example (83%), I grade of 10 example (12%), II grade of 3 example (4%), III grade of 1 example (1%), the total incidence rate of phlebitis is 17%, and more similar report is low a lot.Huang Yue excellent (Huang Yueyou. external Shuang Bai San treatment chemotherapeutic phlebitic clinical observation and nursing [J]. international medical and health Leader, 2007,13 (23): 108 ~ 109) external Shuang Bai San treatment chemotherapeutic phlebitis 95 example, be divided into observation group 50 example and matched group 45 example at random, observation group adds Mel water with Shuang Bai San and dresses affected part, and matched group is with 33% magnesium sulfate yarn block soak affected part.Result: Shuang Bai San treatment Chemotherapy-induced Phlebitis is obviously better than 33%, magnesium sulfate, P < 0.01.Conclusion: Shuang Bai San can protect impaired vein, effectively can reduce all kinds of venous injury that chemotherapeutics causes.5, external washout with traditional Chinese herbs, fumigation and wash method: Hu Yunlong (Hu Yunlong external washout with traditional Chinese herbs treatment antitumor drug causes the analysis of chemotherapeutic phlebitis effect. seek medical advice and medicine, 2012,10 (5)-590-591) etc. homemade traditional Chinese drug washout observe 94 routine chemotherapeutic phlebitis patients, total effective rate 84%.Fang Jigang (observe from intending JieDuQuYuZiYin methods fumigation in treating Chemotherapy-induced Phlebitis. Inner Mongol Chinese medicine .2012,31 (14)-2-3) etc. from intending Chinese traditional herbal medicine treatment chemotherapeutic phlebitis, treatment group pain, red and swollen persistent period comparatively conventional therapy group obviously shorten, therapeutic effect is better than matched group.Chinese medicine prevention chemotherapeutic phlebitis method is numerous, has certain therapeutic effect, and simple to operate, low price, safely, have no side effect, be subject to the accreditation of numerous medical workers, patient, promotion prospect is wide.But experience medication, clinical observers are in the majority, and experimentation, the clinical research of system are less, and research level is low.
Therefore, at present, what also do not have a kind of medical profession to generally acknowledge effectively can treat chemotherapeutic phlebitic medicine.
Summary of the invention
The problems referred to above that the present invention exists to solve the chemotherapeutic phlebitic medicine for the treatment of at present, provide the Chinese medicine of the good prevention and therapy chemotherapeutic phlebitis of a kind of therapeutic effect.
The present invention adopts following technical scheme to realize:
A kind of compound recipe rattan root of Dahurian angelica cream of prevention and therapy chemotherapeutic phlebitis, comprise following drug component and mass fraction proportioning: Resina garciniae 500 ~ 1000 parts, the Radix Angelicae Dahuricae 150 ~ 250 parts, Bulbus Fritillariae Thunbergii 1000 ~ 1500 parts, Radix et Rhizoma Rhei 200 ~ 300 parts, Camphora 200 ~ 300 parts, Borneolum Syntheticum 200 ~ 300 parts, Radix Aucklandiae (Radix Vladimiriae) 100 ~ 300 parts, Herba Menthae 100 ~ 300 parts.
The preparation method of above-mentioned compound recipe rattan root of Dahurian angelica cream: comprise the steps:
(1), by after Resina garciniae, the Radix Angelicae Dahuricae, Bulbus Fritillariae Thunbergii, raw army, Radix Aucklandiae (Radix Vladimiriae), Herba Menthae oven dry, 100 orders are crossed after conventional pulverizing for subsequent use;
(2), for subsequent use by crossing 100 orders after Camphora, the pulverizing of Borneolum Syntheticum routine;
(3) fecula prepared by step (1) and (2) is fully mixed for subsequent use;
(4) add excipient vaseline, lanoline, additional proportion is: fecula: vaseline: lanoline=100:65:15, and fecula and excipient fully stir evenly rear bottled sterilizing and get final product.
In this formula, monarch drug in the Resina garciniae side of being, counteracting toxic substances phagedenoma, removing blood stasis eliminating stagnation, detumescence, hemostasis; Radix Angelicae Dahuricae detumescence and apocenosis, pain relieving; Bulbus Fritillariae Thunbergii powder detoxifcation; The removing pathogenic heat from blood and toxic substance from the body of raw army, eliminating blood stasis and inducing menstruation; Camphora orifice opening, qi stagnation removing, reducing swelling and alleviating pain; Borneolum Syntheticum leads to all keys, loose stagnated fire, the loose poison of heat clearing away; Radix Aucklandiae (Radix Vladimiriae) promoting the circulation of QI to relieve pain; Herba Menthae is anticorrosion, antiinflammatory, analgesia.All medicines share, and become clearing heat and expelling damp altogether, removing toxic substances and promoting pus discharge, reducing swelling and alleviating pain, effect of blood circulation promoting and blood stasis dispelling, the meridian dredging.
The present invention is that light brown is to brown mastic.Medicine for treatment: ointment is evenly applied to affected part, scope of medication Zhou Jing is greater than affected part 1 ~ 2 cm, 2 times/day, and each retention time is 6 hours, 28 hours minor tick times, continuous 6 days.Prophylactic: use before chemotherapeutics, ointment is evenly applied to top about 10 ~ 15 cm of venipuncture point used, to each end of chemotherapy 1 ~ 2 hour, the 8 hours repeated drug takings in interval, to this cycle end of chemotherapy.
The mechanism of compound recipe rattan root of Dahurian angelica cream control chemotherapeutic phlebitis is set forth from molecular biological angle.Compound recipe rattan root of Dahurian angelica cream can suppress the tumor necrosis factor (TNF-α) of mouse tail vein blood vessel endothelium, the expression of VEGF (VEGF).TNF-α cell extensively derives from the various cell such as immunocyte, endotheliocyte, is proportionate with damage index, and TNF-α is that body is subject to internal and external environment to stimulate the cyclin with important biomolecule function produced, and participates in the immunity, inflammation etc. of body.Select TNF-α as the observation index of experimentation.Model group does not carry out any intervention, immunohistochemical staining strong positive.Compound recipe rattan root of Dahurian angelica cream group compares with Hirudoid positive controls, and the TNF-alpha expression of compound recipe rattan root of Dahurian angelica cream is appropriate lower than happiness the Liao Dynasty, and dyeing is in the weak positive.Illustrate that compound recipe rattan root of Dahurian angelica cream is by lowering TNF-alpha expression, alleviates and suppress the symptom of chemotherapeutic phlebitis.VEGF is that a kind of endothelial cell specific mitogenesis is former.VEGF General Expression level in adult normal and animal is lower.Multiple Some Circulating Factors and chemical factors all can induce the expression of VEGF, and as tunica intima anoxia can induce the secretion of VEGF, promote separate sources endothelial cell division propagation and reconstructing blood vessel, vegf expression magnitude relation is to inflammation weight and thrombosis situation.1. VEGF can increase the permeability of blood vessel endothelium; 2. VEGF can the release of stimulating platelet vWF (factor Ⅳ), and impel platelet adhesion on endotheliocyte, inducing thrombosis is formed; 3. VEGF also can produce the thrombin of endotheliocyte, and hyperamization pipe local hypercoagulability.All kinds of factors discharged in thrombosis and inflammatory reaction have again the effect of mutually promoting, aggravation venous injury.VEGF is selected to be the observation index of this experimentation.Result of study confirms, compound recipe high dose group vegf expression is lower than model group, high dose compound recipe rattan root of Dahurian angelica cream is described when blood vessel injury inflammation by reducing vegf expression, edema caused by the vascular permeability suppressing VEGF to cause increases, minimizing thrombosis, cell infiltration and platelet adhesion reaction, reach the phlebitic effect that treatment vinorelbine causes.
Pharmacodynamic test of active extract of the present invention is summarized as follows:
1, method
Select mice to be experimental animal, utilizing Vinorelbine injection for making film medicine, setting up chemotherapeutic phlebitis animal model.
Treatment, prophylactic: compound recipe rattan root of Dahurian angelica cream of the present invention, be divided into respectively height, in two dosage groups.
Western medicine group medicine: it is appropriate that treatment, prevention are happiness the Liao Dynasty.
After medicine for treatment, prophylactic terminate.Observe animal situation and carry out phlebitic classification, light Microscopic observation caudal vein histology pathological change, ImmunohistochemistryMethods Methods detects caudal vein TNF-α and vegf expression.Carry out statistical procedures.
2, result
Prevention: carry out prophylactic immediately after different group tail vein injection vinorelbine, observe Mus tail local and surrounding tissue change, administration is caudal vein and surrounding tissue pathological section, HE dyeing after 5 days, and the pathological characters of light Microscopic observation compound recipe rattan root of Dahurian angelica cream group venous injury is lighter than distant appropriate group of happiness.Treatment: treatment high dose, treatment low dose group, likes the inflammation structure that distant appropriate matched group all can improve chemotherapeutic phlebitis, and the improvement for the treatment of high dose group is obviously better than treatment low dose group, likes distant appropriate matched group.ImmunohistochemistryResults Results is pointed out: compound recipe rattan root of Dahurian angelica cream all can lower TNF-alpha expression with happiness the Liao Dynasty is appropriate, and the TNF-alpha expression of compound recipe rattan root of Dahurian angelica cream is appropriate lower than happiness the Liao Dynasty.Compound recipe rattan root of Dahurian angelica cream all has with happiness the Liao Dynasty is appropriate the effect reducing vegf expression, and the vegf expression for the treatment of high dose is lower than the distant appropriate matched group of happiness.
3, conclusion
Prevention: phlebitis incidence rate and degree of inflammation compare, compound recipe high dose group and like difference between distant appropriate group of group and have statistical significance (P<0.05), prompting compound recipe high dose group phlebitis incidence rate is starkly lower than the distant appropriate matched group of happiness.Treatment high dose group, treatment low dose group compare with the distant appropriate matched group of happiness, there is significant difference (P<0.05) in hemorrhage around thrombosis, blood vessel, fibroplasia, tube chamber hyperemia and vascular endothelial cell come off.Prompting compound recipe high dose group alleviates symptom and the pathological lesion degree of chemotherapeutic phlebitis, and curative effect is better than distant appropriate group of happiness.
Treatment: compound recipe rattan root of Dahurian angelica cream and like distant appropriate group and all can effectively treat mouse chemotherapy phlebitis, improves the inflammation structure of chemotherapeutic phlebitis, and treatment high dose improves and is obviously better than distant appropriate group of happiness.Compound recipe rattan root of Dahurian angelica cream, by lowering Mus tail chemotherapeutic phlebitis TNF-α and vegf expression, effectively can alleviate the pathologic damage of vein blood vessel, alleviates and control chemotherapeutic phlebitis.
The dosage of mouse chemotherapy phlebitis experimental model: the using dosage of modeling medicine vinorelbine: according to the routine clinical dosage of vinorelbine, by pharmacology's formula scales, it is 4.75mg/kg that reference experiment Mouse Weight calculates mice dosage, the using dosage of this modeling is 7 times amount of 4.75mg/kg, volume injected is 0.1ml/10g, the mouse model that this project experimentation uses, becomes mould rate 100%, without animal dead.
Clinical effectiveness of the present invention is summarized as follows:
One, treat
1, method: adopt method that is random, contrast, selects chemotherapeutic phlebitis patient 79 example meeting requirement of experiment, is divided into two groups, treatment group 40 example, matched group 39 example.Treatment group: high dose compound recipe rattan root of Dahurian angelica cream, matched group: happiness the Liao Dynasty is appropriate.Administrated method: 2 times/day.Each retention time is 6 hours, and 2 minor tick times were 8 hours.Administration time is 6 days.Relatively two groups of treatments terminate rear chemotherapeutic phlebitis symptom and improve situation.
2, result: at the end for the treatment of: 1. phlebitis clinical efficacy evaluation: treatment group 0 grade 53.85%, I grade 33.33%, II grade 12.82%, III grade 0.00%; Matched group 0 grade 35.00%, I grade 27.50%, II grade 32.50%, III grade 5.00%.Compare difference between two groups and have statistical significance (P=0.0201), treatment group phlebitis curative effect is better than matched group.2. tcm syndrome therapeutic evaluation: the remarkable improvement rate 85.00% for the treatment of group, effective percentage 100.00%, the remarkable improvement rate 46.16% of matched group, effective percentage 92.31%, comparing difference between two groups has statistical significance (P<0.05).3. individual event symptom therapeutic evaluation: injection site swelling curative effect, injection site pain curative effect, two groups are compared difference and have statistical significance (P<0.05), and treatment group curative effect is better than matched group.And injection site skin rubefaction curative effect, injection site skin heating curative effect, compare difference not statistically significant (P > 0.05) between group.Not there is untoward reaction in experimental session.
3, conclusion: clinical test results confirms that compound recipe rattan root of Dahurian angelica cream effectively can treat chemotherapeutic phlebitis, and improve the clinical symptoms of chemotherapeutic vein, effect is better than Hirudoid.Its curative effect is reliable, and effect is stable, has no side effect, and is the medicine that treatment chemotherapeutic phlebitis is comparatively satisfied with.
Two, prevent
1, method: adopt method that is random, contrast, select 236 examples to meet the patient of requirement of experiment, be divided into two groups at random, prevention group 118 example, matched group 118 example.Treatment group: high dose compound recipe rattan root of Dahurian angelica cream, matched group: happiness the Liao Dynasty is appropriate.Administrated method: after patient venipuncture's success, before defeated chemotherapeutic, two kinds of medicaments uniformity are applied to above the successful vein of puncture along puncture vein direction by 15 ~ 30 min, 1 ~ 2h external application second time medicine after all dripping off to liquid.Two groups of administration times are 5 days.
2, result: prophylactic 5 days ends: prevention group chemotherapeutic phlebitis incidence rate 21.19%, matched group 40.68%, compare difference between two groups and have statistical significance (P<0.05), matched group phlebitis incidence rate is greater than test group (P < 0.05).Chemotherapeutic phlebitis changed in stages: prevention group 0 grade 78.81%, I grade 11.86%, II grade 6.78%, III grade 2.54%; Matched group 0 grade 59.32%, I grade 11.02%, II grade 23.73%, III grade 5.93%; Compare difference between two groups and have statistical significance (P<0.05), matched group phlebitis degree weight.Chemotherapeutic phlebitis time of origin prevention group 4.040 days, matched group 2.833 days, comparing difference between two groups has statistical significance (P<0.05), and prevention group postpones phlebitis time of origin.Chemotherapeutic phlebitis limbs pain degree prevention group 4.280 degree, matched group 5.313 degree, comparing difference between two groups has statistical significance (P<0.05), and prevention group can alleviate limbs pain degree.Not there is untoward reaction in experimental session.
3, conclusion: clinical test results confirms that the external application of compound recipe rattan root of Dahurian angelica cream significantly reduces chemotherapeutic phlebitis incidence rate; reduce the phlebitic generation of severe; postpone phlebitis time of origin; alleviate limbs pain degree; be conducive to the protection of patient vessel; achieve good preventive effect, it is appropriate that preventive effect is better than happiness the Liao Dynasty.
The model case of Chinese medicine of the present invention is as follows:
1, Zhen Husheng, man, 60 years old.Patient is diagnosed as carcinoma of gastric cardia in April, 2009, April 20 row radical correction.Entered my institute July 14 and carry out chemotherapy, use medicine is oxaliplatin, 5-FU.Chemotherapy moves ahead vascular test, and do not have phlebitic symptom, patient does not have main complaint.Chemotherapy uses PeV, the generation of partial smearing compound recipe rattan root of Dahurian angelica cream prevention of phlebitis before infused drug, uses a course for the treatment of continuously.After end of chemotherapy, have no phlebitis.Follow up a case by regular visits to, do not occur phlebitis.
2, Wang Yong, man, 44 years old, small cell lung cancer.JIUYUE enters my institute on the 15th and carries out chemotherapy, and chemotherapeutics is ifosfamide, etoposide, cisplatin, and chemotherapy moves ahead vascular test, and do not have phlebitic symptom, patient does not have main complaint.Chemotherapy uses PeV, the generation of partial smearing compound recipe rattan root of Dahurian angelica cream prevention of phlebitis before infused drug, uses a course for the treatment of continuously.After end of chemotherapy, have no phlebitis.Follow up a case by regular visits to, do not occur phlebitis.
3, Xu Zhanzhong, man, 60 years old, hypopharynx squamous cell carcinoma was postoperative, and my institute of 7 monthly incomes in 2009, improve every inspection, carry out chemotherapy, medicine is paclitaxel, cisplatin.Chemotherapy moves ahead vascular test, and do not have phlebitic sign, patient does not have main complaint.Chemotherapy uses PeV, the generation of partial smearing compound recipe rattan root of Dahurian angelica cream prevention of phlebitis before infused drug, uses a course for the treatment of continuously.After end of chemotherapy, have no phlebitis.Follow up a case by regular visits to, do not occur phlebitis.
4, Wang Min, man, 72 years old, rectal carcinoma radical is postoperative, for asking further treatment, and my institute of 3 monthly incomes in 2008, improve every inspection, see right upper extremity lower end and right side the back of the hand local swelling, blackout, hardening, tactile pain, have streak change, be diagnosed as chemotherapeutic phlebitis three grades, chemotherapeutic exosmoses.Use compound recipe rattan root of Dahurian angelica cream 8 days, symptom is obviously improved, and upper limb and right hand activity are freely.Follow up a case by regular visits to, do not recur.
5, Feng Shutian, man, 78 years old, cardia body of stomach cancer, left clavicle superior gluteal lymph node shifts, in my institute of 5 monthly incomes in 2008, improve every inspection, see that left upper extremity forearm vein has streak change, the pain touched, local is dark red, is diagnosed as phlebitis secondary, and use compound recipe rattan root of Dahurian angelica cream two course for the treatment of, symptom is obviously improved.Follow up a case by regular visits to, do not recur.
The present invention take Resina garciniae as the chemotherapeutic phlebitic medicament composing prescription of monarch drug treatment, with clearing heat and expelling damp, removing toxic substances and promoting pus discharge, reducing swelling and alleviating pain, blood circulation promoting and blood stasis dispelling, the meridian dredging are method for the treatment of, prevention and therapy chemotherapeutic phlebitis, there is provided a kind of therapeutic effect definite, become the medicine that provincialism or medical circle generally acknowledge, prevention and therapy chemotherapeutic phlebitis effectively, reduces the untoward reaction of chemotherapy to greatest extent, alleviate the misery of patients undergoing chemotherapy, help patients undergoing chemotherapy to complete chemotherapy smoothly.
Detailed description of the invention
Below specific embodiments of the invention are described in detail.
embodiment 1
A compound recipe rattan root of Dahurian angelica cream for prevention and therapy chemotherapeutic phlebitis, comprises following drug component and mass fraction proportioning: 1 gram every part,
Resina garciniae 700 parts, the Radix Angelicae Dahuricae 250 parts, Bulbus Fritillariae Thunbergii 1000 parts, raw army 220 parts, Camphora 300 parts, Borneolum Syntheticum 250 parts, Radix Aucklandiae (Radix Vladimiriae) 180 parts, Herba Menthae 200 parts.
The preparation method of above-mentioned compound recipe rattan root of Dahurian angelica cream: comprise the steps:
(1), by after Resina garciniae, the Radix Angelicae Dahuricae, Bulbus Fritillariae Thunbergii, raw army, Radix Aucklandiae (Radix Vladimiriae), Herba Menthae oven dry, 100 orders are crossed after conventional pulverizing for subsequent use;
(2), for subsequent use by crossing 100 orders after Camphora, the pulverizing of Borneolum Syntheticum routine;
(3) fecula prepared by step (1) and (2) is fully mixed for subsequent use;
(4) add excipient vaseline, lanoline, additional proportion is: fecula: vaseline: lanoline=100:65:15, and fecula and excipient fully stir evenly rear bottled sterilizing and get final product, every bottled 30g.
embodiment 2
A compound recipe rattan root of Dahurian angelica cream for prevention and therapy chemotherapeutic phlebitis, comprises following drug component and mass fraction proportioning: 2 grams every part,
Resina garciniae 500 parts, the Radix Angelicae Dahuricae 150 parts, Bulbus Fritillariae Thunbergii 1300 parts, raw army 300 parts, Camphora 270 parts, Borneolum Syntheticum 230 parts, Radix Aucklandiae (Radix Vladimiriae) 200 parts, Herba Menthae 300 parts.
The preparation method of above-mentioned compound recipe rattan root of Dahurian angelica cream: comprise the steps:
(1), by after Resina garciniae, the Radix Angelicae Dahuricae, Bulbus Fritillariae Thunbergii, raw army, Radix Aucklandiae (Radix Vladimiriae), Herba Menthae oven dry, 100 orders are crossed after conventional pulverizing for subsequent use;
(2), for subsequent use by crossing 100 orders after Camphora, the pulverizing of Borneolum Syntheticum routine;
(3) fecula prepared by step (1) and (2) is fully mixed for subsequent use;
(4) add excipient vaseline, lanoline, additional proportion is: fecula: vaseline: lanoline=100:65:15, and fecula and excipient fully stir evenly rear bottled sterilizing and get final product, every bottled 50g.
embodiment 3
A compound recipe rattan root of Dahurian angelica cream for prevention and therapy chemotherapeutic phlebitis, comprises following drug component and mass fraction proportioning: 5 grams every part,
Resina garciniae 800 parts, the Radix Angelicae Dahuricae 200 parts, Bulbus Fritillariae Thunbergii 1200 parts, raw army 280 parts, Camphora 200 parts, Borneolum Syntheticum 300 parts, Radix Aucklandiae (Radix Vladimiriae) 150 parts, Herba Menthae 250 parts.
The preparation method of above-mentioned compound recipe rattan root of Dahurian angelica cream: comprise the steps:
(1), by after Resina garciniae, the Radix Angelicae Dahuricae, Bulbus Fritillariae Thunbergii, raw army, Radix Aucklandiae (Radix Vladimiriae), Herba Menthae oven dry, 100 orders are crossed after conventional pulverizing for subsequent use;
(2), for subsequent use by crossing 100 orders after Camphora, the pulverizing of Borneolum Syntheticum routine;
(3) fecula prepared by step (1) and (2) is fully mixed for subsequent use;
(4) add excipient vaseline, lanoline, additional proportion is: fecula: vaseline: lanoline=100:65:15, and fecula and excipient fully stir evenly rear bottled sterilizing and get final product, every bottled 30g.
embodiment 4
A compound recipe rattan root of Dahurian angelica cream for prevention and therapy chemotherapeutic phlebitis, comprises following drug component and mass fraction proportioning: 1 gram every part,
Resina garciniae 1000 parts, the Radix Angelicae Dahuricae 170 parts, Bulbus Fritillariae Thunbergii 1500 parts, raw army 200 parts, Camphora 250 parts, Borneolum Syntheticum 270 parts, Radix Aucklandiae (Radix Vladimiriae) 100 parts, thin 100 parts.
The preparation method of above-mentioned compound recipe rattan root of Dahurian angelica cream: comprise the steps:
(1), by after Resina garciniae, the Radix Angelicae Dahuricae, Bulbus Fritillariae Thunbergii, raw army, Radix Aucklandiae (Radix Vladimiriae), Herba Menthae oven dry, 100 orders are crossed after conventional pulverizing for subsequent use;
(2), for subsequent use by crossing 100 orders after Camphora, the pulverizing of Borneolum Syntheticum routine;
(3) fecula prepared by step (1) and (2) is fully mixed for subsequent use;
(4) add excipient vaseline, lanoline, additional proportion is: fecula: vaseline: lanoline=100:65:15, and fecula and excipient fully stir evenly rear bottled sterilizing and get final product, every bottled 30g.
embodiment 5
A compound recipe rattan root of Dahurian angelica cream for prevention and therapy chemotherapeutic phlebitis, comprises following drug component and mass fraction proportioning: 1 gram every part,
Resina garciniae 600 parts, the Radix Angelicae Dahuricae 220 parts, Bulbus Fritillariae Thunbergii 1100 parts, raw army 250 parts, Camphora 230 parts, Borneolum Syntheticum 200 parts, Radix Aucklandiae (Radix Vladimiriae) 300 parts, thin 150 parts.
The preparation method of above-mentioned compound recipe rattan root of Dahurian angelica cream: comprise the steps:
(1), by after Resina garciniae, the Radix Angelicae Dahuricae, Bulbus Fritillariae Thunbergii, raw army, Radix Aucklandiae (Radix Vladimiriae), Herba Menthae oven dry, 100 orders are crossed after conventional pulverizing for subsequent use;
(2), for subsequent use by crossing 100 orders after Camphora, the pulverizing of Borneolum Syntheticum routine;
(3) fecula prepared by step (1) and (2) is fully mixed for subsequent use;
(4) add excipient vaseline, lanoline, additional proportion is: fecula: vaseline: lanoline=100:65:15, and fecula and excipient fully stir evenly rear bottled sterilizing and get final product, every bottled 30g.
Claims (2)
1. a compound recipe rattan root of Dahurian angelica cream for prevention and therapy chemotherapeutic phlebitis, is characterized in that: comprise following drug component and mass fraction proportioning:
Resina garciniae 500 ~ 1000 parts, the Radix Angelicae Dahuricae 150 ~ 250 parts, Bulbus Fritillariae Thunbergii 1000 ~ 1500 parts, raw army 200 ~ 300 parts, Camphora 200 ~ 300 parts, Borneolum Syntheticum 200 ~ 300 parts, Radix Aucklandiae (Radix Vladimiriae) 100 ~ 300 parts, Herba Menthae 100 ~ 300 parts.
2. the preparation method of the compound recipe rattan root of Dahurian angelica cream of a prevention and therapy chemotherapeutic phlebitis according to claim 1: it is characterized in that: comprise the steps:
(1), take the Resina garciniae of predetermined weight, the Radix Angelicae Dahuricae, Bulbus Fritillariae Thunbergii, raw army, Radix Aucklandiae (Radix Vladimiriae), Herba Menthae dry, conventional pulverize after to cross 100 orders for subsequent use;
(2), take Camphora, the Borneolum Syntheticum of predetermined weight, conventional pulverize after to cross 100 orders for subsequent use;
(3) fecula prepared by step (1) and (2) is fully mixed for subsequent use;
(4) add excipient vaseline, lanoline, additional proportion is: fecula: vaseline: lanoline=100:65:15, and fecula and excipient fully stir evenly rear bottled sterilizing and get final product.
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| CN1745779A (en) * | 2004-09-10 | 2006-03-15 | 周景和 | Chinese medicine for treating angiitis and phlebitis etc. thromboembolia disease |
| CN101810777A (en) * | 2009-02-19 | 2010-08-25 | 邵友元 | Formula of ointment for treating red and swollen heat pain |
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