CN1742773A - Xihuang preparation and new preparing method - Google Patents
Xihuang preparation and new preparing method Download PDFInfo
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- CN1742773A CN1742773A CNA2005101053524A CN200510105352A CN1742773A CN 1742773 A CN1742773 A CN 1742773A CN A2005101053524 A CNA2005101053524 A CN A2005101053524A CN 200510105352 A CN200510105352 A CN 200510105352A CN 1742773 A CN1742773 A CN 1742773A
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Abstract
The present invention relates to a Chinese medicine Xihuang preparation for curing swollen welling abscesses, flat abscesses and clove sores, scrofula, streaming sore and carcinomatosis. It is made up by using (by weight portion) 15 portions of cow-bezoare, 15 portion of musk, 550 portions of frankincense (mix-fried with vinegar) and 550 portions of myrrh (mix-fried with vinegar). Said Chinese medicine Xihuang preparation can be made into various dosage forms including dripping pills and soft capsule, etc.
Description
Technical field:
The present invention relates to a kind of Chinese medicine composition and preparation technology thereof, particularly a kind of treatment carbuncle furunculosis, scrofula, multiple abscess, the preparation recipe of cancerous protuberance and preparation technology thereof.
Background technology:
The cellulitis that the traditional Chinese medical science is said is to occur in a plurality of hair follicles that close on mutually of skin and the acute festering type disease of attached sebaceous gland thereof; The carbuncle that the traditional Chinese medical science is said is the acute festering type disease that occurs between the skin and flesh, and both all are the acute festering type illness between generation and skin and the muscle.The multiple abscess skin lesion appearing without definite location is better than the muscle depths, difficult recovery from illness.Since cause of disease difference, dialectical multiple abscess due to heat-damp in summer, residual poison multiple abscess, the multiple abscess due to blood stasis of being divided into of the different bed of symptom.
Calculus Bovis waking up the patient from unconsciousness by dissipating phlegm among the we, cool liver endogenous wind stopping, heat-clearing and toxic substances removing; The Moschus refreshment of having one's ideas straightened out, promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain; Olibanum and Myrrha be the energy detumescence and promoting granulation all, promoting blood circulation and stopping pain; Four medicines share, and reach heat-clearing and toxic substances removing and battalion's repercussive effect, and the preparation after the change extraction process is easy to dissolving and absorption than elite and thick putting that ordinary pill more can collect medicine, and curative effect is fast, and administration time is short, and therefore, curative effect is better.
The purpose of this invention is to provide a kind of therapeutic domain wide, easily accept, easily absorb, the preparation technology of efficient, low dosage, the Chinese medicine dripping pills that has no side effect, soft capsule, granule, chewable tablet, capsule, tablet, pill, its pill that makes can be used for curing mainly the carbuncle furunculosis, scrofula, multiple abscess, cancerous protuberance etc.
Summary of the invention:
The present invention relates to a kind of prescription and preparation technology thereof of Chinese medicine preparation, it is characterized in that, the preparation of per 1000 dosage units is made up of following proportion raw material and adjuvant:
7～90 parts in 7～90 parts of Moschus of Calculus Bovis
200～3300 parts of 200～3300 parts of Myrrhas of Olibanum (vinegar system) (vinegar system)
Preferably:
550 parts of 15 parts of 15 parts of Olibanums of Moschus of Calculus Bovis (vinegar system)
550 parts of Myrrhas (vinegar system)
In more than forming, the weight of medicine is calculated with crude drug, and per 1 part can be 1 gram, also can be kilogram or ton, if be unit with gram, this prescription composition can be made into 1000 doses of pharmaceutical preparatioies.Described 1000 doses of fingers, the final drug preparation of making, as make 1000 of soft capsule preparations, granule 1000g etc. also can make big packing as granule, as the 100-500 bag, specifically can be 100 bags, 125 bags, 200 bags, 250 bags, 500 bags etc., every bag can be used as taking dose 1 time.
More than form, can be made into the preparation of 50-1000 taking dose,, make 125 bags, take the 1-2 bag at every turn, can take 62.5-125 time altogether as granule.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The raw material of Chinese medicine of said ratio extracts processing through new technology of the present invention, obtain the active constituents of medicine of preparation of the present invention, add suitable excipient as required and make suitable medicinal any dosage form, said preparation can be drop pill, soft capsule, granule, chewable tablet, tablet, capsule or pill.
The above new technology of the present invention may further comprise the steps:
Method a:
(1) get Olibanum, Myrrha, break into pieces behind the freezing 2h, with water extraction twice, each 2 hours, merge water and guide and support, add 2 times of amount 95% ethanol precipitate with ethanol, leave standstill 24h, decompress filter, filtrate decompression is condensed into thick extractum, and is standby; The slag of getting it filled is measured 95% ethanol with 2 times, dipping 24h decompress filter, the dry dry extract that gets of filtrate decompression.Merge standby;
(2) get bovine calculus powder and be broken into fine powder and put in the container, it is an amount of to add 20% sodium hydroxide solution, and hydrolysis 20h in the water-bath makes its hydrolysis complete.The concentrated hydrochloric acid acidify filters, and insoluble matter extracts with ethyl acetate backflow, and extracting solution is concentrated into 100ml, filters, and is standby.
Above extract lumps together the active constituents of medicine into preparation of the present invention; This active component is suitable for preparing drop pill of the present invention and soft capsule preparation.
Method b:
(1) Olibanum, Myrrha pulverize separately are become coarse powder,, put in people's extraction kettle, press positive quadraturing design test, determine that the optimum extraction process scheme is: pressure 35mpa, 55 ℃ of temperature, time 2h, flow 22kg/h by 1: 1 mix homogeneously.Extract yield is 8.0～8.1%, and extract is standby;
(2) get Calculus Bovis, Moschus is ground into fine powder, and is standby.
Above extract lumps together the active constituents of medicine into preparation of the present invention; This active component is suitable for preparing other dosage forms except that drop pill and soft capsule preparation of the present invention.
The active constituents of medicine of the preparation of the present invention that above method obtains can be prepared into preparation of the present invention through further processing.
Preparation of the present invention, different dosage form method difference below is the preparation method of several preferred dosage form.
(1) preparation of drop pill
Drop pill of the present invention, wherein the ratio of active component and adjuvant is 1: 0.5～10, and preferred ratio is 1: 2～4, and most preferred ratio is 1: 3.The above adjuvant be specially molecular weight polyethylene glycol between 400 to 10000 Polyethylene Glycol and their mixture, as PEG400 (PEG400), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000, perhaps their mixture or other suitable other auxiliary elements such as glycerol, gelatin or stearic acid sodium etc. of making drop pill.
Following steps are taked in the preparation of drop pill of the present invention:
1. be ready to following raw material: active component, adjuvant and/or other inactive ingredients;
2. with the above-mentioned raw materials mix homogeneously;
3. add the transconversion into heat material, move into the drip irrigation of drop pill machine, medicinal liquid splashes in the liquid sub liquid paraffin by water dropper, removes liquid paraffin, selects ball, promptly.
(2) preparation of soft capsule
Soft capsule preparation of the present invention is that active component and pharmaceutically useful organic solvent and the material of making soft capsule shell are formed.Organic solvent wherein is selected from PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, the material of wherein making soft capsule shell is gelatin or arabic gum, water, plasticizer and antiseptic, the weight ratio of gelatin or arabic gum and plasticizer is 1.0: 0.4～1.0 in the soft capsule shell, and the weight ratio of gelatin and water is 1.0: 0.8～1.2.Wherein the weight proportion between active component and the pharmaceutically useful organic solvent is: the content of active component is 50mg-500mg in every soft capsule.
The preparation method of preparation of the present invention, the process following steps:
A. get gelatin, glycerol, pure water adds thermosol, adds an amount of antiseptic, preparation rubber;
B gets active component and is dissolved in organic solvent, adds suitable quantity of water, is prepared into soft capsule through encapsulating machine.
(3) preparation process of tablet is as follows: with above-mentioned extract obtained, granulate with Calculus Bovis, Moschus medicated powder, add lubricant, tabletting promptly gets tablet.
(4) preparation process of granule is as follows: granulate with Calculus Bovis, Moschus medicated powder, add a certain amount of correctives, filler, lubricant, granulate, promptly get granule.
Filler described in the preparation such as granule, chewable tablet is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.; Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture; Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
Following data declaration beneficial effect of the present invention by experiment:
In order to prove the Clinical feasibility that changes after the technology, we have carried out its main pharmacodynamics, toxicologic study to this medicine, observe its therapeutical effect, and the clinical experimental basis that provides is provided.
(1) the analgesic experiment of rabbit
Select rabbit for use, body weight 1.5～2.0Kg, male and female half and half.Choose body temperature between 38.5～39.5 ℃, and basal body temperature changes less than 32 of 0.5 ℃ qualified rabbit for three days on end, be divided into 4 groups at random, every group 8, be blank group (distilled water 10ml/Kg), aspirin matched group (0.1g/kg), XIHUANG WAN technology be extractum group (0.022g/kg) 1., and technology is extractum group (0.025g/kg) 2..Administering mode gavages, and behind the administration 30min, auricular vein injection antityphoid vaccine 1ml/Kg begins to measure the anus temperature behind the 30min respectively, and every 0.5h surveys 1 time, surveys 4h continuously.The results are shown in Table 1.
The influence of fever in rabbits body temperature due to the table 1 pair antityphoid vaccine (n=8, ℃, x ± s)
| Group | Before the administration | Different time temperature after the administration | |||
| 30min | 60min | 90min | 120min | ||
| Blank aspirin group technology is 2. extractum group of extractum group technology 1. | 39.7±0.64 39.6±0.69 39.3±0.55 39.5±0.65 | 0.85±0.51 0.42±0.20 * 0.54±0.27 * 0.83±0.25 | 1.49±0.55 0.86±0.19 ** 1.09±0.38 ** 1.25±0.30 * | 1.07±0.49 0.60±0.25 ** 0.61±0.19 ** 0.61±0.19 * | 0.01±0.44 0.38±0.21 * 0.28±0.12 ** 0.25±0.32 ** |
| Different time temperature after the administration | |||
| 150min | 180min | 210min | 240min |
| 0.51±0.35 0.34±0.18 * 0.18±0.14 ** 0.35±0.12 * | 0.56±0.48 0.26±0.40 * 0.13±0.15 ** 0.21±0.25 * | 0.39±0.46 0.25±0.42 0.12±0.20 * 0.10±0.31 * | 0.13±0.45 0.03±0.15 0.06±0.18 0.14±0.30 |
Annotate: compare with extremely white group,
*P＜0.01,
*P＜0.05
The result shows: 30min after the vaccinate, each is organized rabbit body temperature and all significantly rises, the 1h peaking, 1.49 ℃ of blank group body temperature rise, 0.86～1.25 ℃ of each administration group body temperature rise, show technology 1. extractum group and technology 2. the extractum group body temperature rise is all had inhibitory action, wherein 1. the effect of extractum group is particularly remarkable with technology, and is close with the aspirin matched group.Behind the 2h technology 1. the reduction amplitude of extractum group body temperature greater than the aspirin matched group.
(2) toxicological study
Acute toxicity test shows that rat oral gavage extract of the present invention fails to measure LD
50
Long term toxicity test: rat grouping, extract of the present invention is irritated stomach, every day three times, connect and annotate 90d, the result, administration group rat and control rats movable, search for food, drinking-water, body weight and multinomial observation indexs such as substantial viscera pathologic finding and histopathology detect, result of the test is not all found any toxicity; Hemogram and hepatic and renal function index and the equal no significant difference of matched group.
The blood vessel irritation of this medicine, allergy and hemolytic test all are negative.
In sum, preparation of the present invention, dropping pill formulation particularly of the present invention and soft capsule preparation are a kind of good treatment hat carbuncle furunculosiss, scrofula, multiple abscess, the medicine of cancerous protuberance, and change preparation technology, can obviously strengthen its heat-clearing and toxic substances removing, with battalion's clinical efficacy such as detumescence grade, there is not tangible toxicity, prolonged application safety in addition, therefore, being worth clinical further applies.
The specific embodiment:
Further specify the present invention by the following examples, include but not limited to the following example.
Embodiment 1:
The preparation method of drop pill of the present invention:
Prescription:
Calculus Bovis 15g Moschus 15g Olibanum (vinegar system) 550g
Myrrha (vinegar system) 550g PEG400 100g
Make 1000 balls
Preparation method:
Get Olibanum, Myrrha, break into pieces behind the freezing 2h, with water extraction twice, each 2 hours, merge water and guide and support, add 2 times of amount 95% ethanol precipitate with ethanol, leave standstill 24h, decompress filter, filtrate decompression is condensed into thick extractum, and is standby; The slag of getting it filled is measured 95% ethanol with 2 times, dipping 24h decompress filter, the dry dry extract that gets of filtrate decompression.Merge standby; Get bovine calculus powder and be broken into fine powder and put in the container, it is an amount of to add 20% sodium hydroxide solution, and hydrolysis 20h in the water-bath makes its hydrolysis complete.The concentrated hydrochloric acid acidify filters, and insoluble matter extracts with ethyl acetate backflow, and extracting solution is concentrated into 100ml, filters, and is standby; With above-mentioned extract obtained and Moschus merging, the PEG400 that adds recipe quantity puts into the vessel in heating dissolving, and jolting makes and dissolves into uniform solution, inserts in the fluid reservoir.Keep 80 ℃ the system of dripping temperature, and a control speed, condensed fluid is a liquid paraffin, drips system promptly.
Embodiment 2:
Preparation of soft capsule method of the present invention:
Prescription:
Calculus Bovis 30g Moschus 30g Olibanum (vinegar system) 1100g
Myrrha (vinegar system) 1100g PEG400 200g
Make 1000
Preparation method:
Get Olibanum, Myrrha, break into pieces behind the freezing 2h, with water extraction twice, each 2 hours, merge water and guide and support, add 2 times of amount 95% ethanol precipitate with ethanol, leave standstill 24h, decompress filter, filtrate decompression is condensed into thick extractum, and is standby; The slag of getting it filled is measured 95% ethanol with 2 times, dipping 24h decompress filter, the dry dry extract that gets of filtrate decompression.Merge standby; Get bovine calculus powder and be broken into fine powder and put in the container, it is an amount of to add 20% sodium hydroxide solution, and hydrolysis 20h in the water-bath makes its hydrolysis complete.The concentrated hydrochloric acid acidify filters, and insoluble matter extracts with ethyl acetate backflow, and extracting solution is concentrated into 100ml, filters, and is standby; With above-mentioned extract obtained and Moschus merging, add an amount of PEG400 mixing and pulverizing, add the PEG400 of surplus then, promptly get medicinal liquid.It is standby in addition to join gelatin solution by certain prescription.The condition that control is suitable splashes in the coolant (liquid paraffin), promptly.
Embodiment 3:
The preparation method of tablet of the present invention:
Prescription:
Calculus Bovis 30g Moschus 30g Olibanum (vinegar system) 1100g
Myrrha (vinegar system) 1100g
Make 1000
Preparation method:
Olibanum, Myrrha pulverize separately are become coarse powder,, put in people's extraction kettle, press positive quadraturing design test, determine that the optimum extraction process scheme is: pressure 35mpa, 55 ℃ of temperature, time 2h, flow 22kg/h by 1: 1 mix homogeneously.Extract yield is 8.0～8.1%, and extract is standby; Get Calculus Bovis, Moschus is ground into fine powder, and is standby; Use 80% alcohol granulation, drying adds magnesium stearate 5.0g, and mixing, tabletting are promptly.
Embodiment 4:
The preparation method of granule of the present invention:
Prescription:
Calculus Bovis 90g Moschus 90g Olibanum (vinegar system) 3300g
Myrrha (vinegar system) 3300g
Make 1000g
Preparation method:
Olibanum, Myrrha pulverize separately are become coarse powder,, put in people's extraction kettle, press positive quadraturing design test, determine that the optimum extraction process scheme is: pressure 35mpa, 55 ℃ of temperature, time 2h, flow 22kg/h by 1: 1 mix homogeneously.Extract yield is 8.0～8.1%, and extract is standby; Get Calculus Bovis, Moschus is ground into fine powder, and is standby; Add aspartame 5.0g, dextrin 300.0g, granulate, drying sprays into essence 5.0g, promptly gets granule.
Claims (10)
1, a kind of Chinese medicine composition is characterized in that per 1000 dosage units are made by the following weight proportion raw material:
7～90 parts in 7～90 parts of Moschus of Calculus Bovis
200～3300 parts of 200～3300 parts of Myrrhas of Olibanum (vinegar system) (vinegar system)
2, the compound preparation of claim 1～2 is characterized in that per 1000 dosage units are made by the following weight proportion raw material:
550 parts of 15 parts of 15 parts of Olibanums of Moschus of Calculus Bovis (vinegar system)
550 parts of Myrrhas (vinegar system)
3, claim 1 or any one Chinese medicine preparation of 2 are drop pill, soft capsule, granule, chewable tablet, tablet, capsule or pill.
4, the Chinese medicine preparation of claim 3 through described raw material is extracted processing, obtains active component, adds suitable adjuvant as required and makes.
5, the Chinese medicine preparation of claim 4 is characterized in that, described active component prepares through following steps:
Method a:(technology 1.)
(1) get Olibanum, Myrrha, break into pieces behind the freezing 2h, with water extraction twice, each 2 hours, merge water and guide and support, add 2 times of amount 95% ethanol precipitate with ethanol, leave standstill 24h, decompress filter, filtrate decompression is condensed into thick extractum, and is standby; The slag of getting it filled is measured 95% ethanol with 2 times, dipping 24h decompress filter, the dry dry extract that gets of filtrate decompression.Merge standby;
(2) get bovine calculus powder and be broken into fine powder and put in the container, it is an amount of to add 20% sodium hydroxide solution, and hydrolysis 20h in the water-bath makes its hydrolysis complete.The concentrated hydrochloric acid acidify filters, and insoluble matter extracts with ethyl acetate backflow, and extracting solution is concentrated into 100ml, filters, and is standby.
Above extract lumps together the active constituents of medicine into preparation of the present invention; This active component is suitable for preparing drop pill of the present invention and soft capsule preparation.
Method b:(technology 2.)
(1) Olibanum, Myrrha pulverize separately are become coarse powder,, put in people's extraction kettle, press positive quadraturing design test, determine that the optimum extraction process scheme is: pressure 35mpa, 55 ℃ of temperature, time 2h, flow 22kg/h by 1: 1 mix homogeneously.Extract yield is 8.0～8.1%, and extract is standby;
(2) get Calculus Bovis, Moschus is ground into fine powder, and is standby.
Above extract lumps together the active constituents of medicine into preparation of the present invention; This active component is suitable for preparing other dosage forms except that drop pill and soft capsule preparation of the present invention.
6, the Chinese medicine preparation of claim 5, it is characterized in that: described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60-115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, coolant temperature is-and 10-5 ℃.
7, the Chinese medicine preparation of claim 5 is characterized in that: described soft capsule, and its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg-500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.Its preparation method is: with active constituents of medicine and proper auxiliary materials mix homogeneously, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
8, the Chinese medicine preparation of claim 5 is characterized in that:
The preparation process of tablet is as follows: with above-mentioned extract obtained, granulate with Calculus Bovis, Moschus medicated powder, add lubricant, tabletting promptly gets tablet.
The preparation process of granule is as follows: granulate with Calculus Bovis, Moschus medicated powder, add a certain amount of correctives, filler, lubricant, granulate, promptly get granule.
9, the Chinese medicine preparation of claim 8 is characterized in that: described filler is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.; Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture; Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
10, the preparation method of any one Chinese medicine preparation of claim 1-9 is characterized in that, the process following steps:
Described raw material of Chinese medicine is extracted processing, obtain active component, add suitable adjuvant and make; Wherein said active component prepares through following steps:
Method a:
(1) get Olibanum, Myrrha, break into pieces behind the freezing 2h, with water extraction twice, each 2 hours, merge water and guide and support, add 2 times of amount 95% ethanol precipitate with ethanol, leave standstill 24h, decompress filter, filtrate decompression is condensed into thick extractum, and is standby; The slag of getting it filled is measured 95% ethanol with 2 times, dipping 24h decompress filter, and the dry dry extract that gets of filtrate decompression merges standby;
(2) get bovine calculus powder and be broken into fine powder and put in the container, it is an amount of to add 20% sodium hydroxide solution, and hydrolysis 20h in the water-bath makes its hydrolysis complete.The concentrated hydrochloric acid acidify filters, and insoluble matter extracts with ethyl acetate backflow, and extracting solution is concentrated into 100ml, filters, and is standby.
Above extract lumps together the active constituents of medicine into preparation of the present invention; This active component is suitable for preparing drop pill of the present invention and soft capsule preparation.
Method b:
(1) Olibanum, Myrrha pulverize separately are become coarse powder,, put in people's extraction kettle, press positive quadraturing design test, determine that the optimum extraction process scheme is: pressure 35mpa, 55 ℃ of temperature, time 2h, flow 22kg/h by 1: 1 mix homogeneously.Extract yield is 8.0～8.1%, and extract is standby;
(2) get Calculus Bovis, Moschus is ground into fine powder, and is standby.
Above extract lumps together the active constituents of medicine into preparation of the present invention; This active component is suitable for preparing other dosage forms except that drop pill and soft capsule preparation of the present invention;
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60-115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, coolant temperature is-and 10-5 ℃.
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg-500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.Its preparation method is: with active constituents of medicine and proper auxiliary materials mix homogeneously, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2005101053524A CN1742773A (en) | 2005-09-23 | 2005-09-23 | Xihuang preparation and new preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2005101053524A CN1742773A (en) | 2005-09-23 | 2005-09-23 | Xihuang preparation and new preparing method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1742773A true CN1742773A (en) | 2006-03-08 |
Family
ID=36138398
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2005101053524A Pending CN1742773A (en) | 2005-09-23 | 2005-09-23 | Xihuang preparation and new preparing method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102895283A (en) * | 2012-10-25 | 2013-01-30 | 山东中医药大学 | Xi Huang dropping pill molding process |
| CN104000864A (en) * | 2014-06-19 | 2014-08-27 | 四川金堂海纳生物医药技术研究所 | Oral administration medicine for treating panaritium and preparing method of oral administration medicine |
-
2005
- 2005-09-23 CN CNA2005101053524A patent/CN1742773A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102895283A (en) * | 2012-10-25 | 2013-01-30 | 山东中医药大学 | Xi Huang dropping pill molding process |
| CN102895283B (en) * | 2012-10-25 | 2015-01-07 | 山东中医药大学 | Xi Huang dropping pill molding process |
| CN104000864A (en) * | 2014-06-19 | 2014-08-27 | 四川金堂海纳生物医药技术研究所 | Oral administration medicine for treating panaritium and preparing method of oral administration medicine |
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