CN1739760A - Stomach-benefiting medicine and its prepn - Google Patents
Stomach-benefiting medicine and its prepn Download PDFInfo
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- CN1739760A CN1739760A CNA2005100606328A CN200510060632A CN1739760A CN 1739760 A CN1739760 A CN 1739760A CN A2005100606328 A CNA2005100606328 A CN A2005100606328A CN 200510060632 A CN200510060632 A CN 200510060632A CN 1739760 A CN1739760 A CN 1739760A
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Abstract
The present invention relates to Chinese medicine with the functions of benefiting stomach, regulating the middle warmer, regulating vital energy and eliminating turbid evil, and the Chinese medicine is prepared with 12 kinds of Chinese medicinal materials including Chinese goldthread, red ginseng, fritillary, notoginseng, bitter orange, etc. The present invention is prepared with medicated food materials and treats gastropathy by means of the synergistic effect of the medicine materials. The Chinese medicine can remit and cure gastropathy and other complications. In addition, the Chinese medicine has no need of decoction, simple preparation process and convenient taking.
Description
Technical field
The present invention relates to a kind of stomach reinforcing and in, the turbid medicine of regulating the flow of vital energy, be the Chinese patent medicine of feedstock production with the Chinese herbal medicine specifically, the invention still further relates to the preparation method of this medicine.
Background technology
Because very fast, the operating pressure of modern's rhythm of life is big, diet does not have rule, very easily cause the imbalance of digestive tract disease and digestive tract function, population based in, the youth, belong to the age bracket occurred frequently of digestive tract disease.Have data to show that the sickness rate of the various chronic stomaches of white collar class, intestinal diseases is up to 70%, this is an alarming numeral; And the prescription on individual diagnosis rate has only about 13%, and this is a discomforting numeral especially.Common people think that gastrointestinal disease is common disease, and from the medical science angle analysis, and this disease is if can not get correctly treating timely, and the lighter influences people's quality of life, ignore patient's carcinogenesis of diagnosis and treatment but part has early warning signal and threat to life;
The lighter of gastropathy influences people's quality of life, complication extensively and seriously, cause the digestive function reduction to cause dyspepsia because body of gland atrophy and gastric acid descend, gastric content is detained or bile reflux, stimulates coat of the stomach to cause epigastric discomfort, feeling of repletion and dull pain, vagal excitation is low, gastric peristalsis is weak and emptying is slow, and gastric content easily is detained, gastrin cell pressurized and secrete gastrin, gastric acid is increased, performance pain; Pylorus expanded about flesh and is upset and spasm when gastric juice increased, and gastric emptying is obstructed, and gastric juice backflows to cause to esophagus or oral cavity and returns acid, and gastric content emptying difficulty causes that food ferments and dyspepsia causes belch; Can cause gastrorrhagia, anemia in addition, cause symptoms such as acute diffuse peritonitis, blood pressure drops, hemorrhagic shock;
Both at home and abroad to the gastropathy Drug therapy, run into following thorny problem at present
1.H
2Receptor blocking class medicine mainly contains headache, giddy, xerostomia, feels sick, abdominal distention, insomnia, and idol has erythra, peripheral nervous inflammation, serum aminotransferase or bilirubin to increase, and continues the gastric acid inhibitory secretion for a long time, can cause the gastric bacterial growth.
2.M the cholinoceptor blocking agent often has xerostomia, blurred vision, heart rate quickening, platycoria and erubescence etc., also obvious poisoning symptom can occur sometimes.
3. the mucous membrane protection medicine diarrhoea, xerostomia often occur, feels sick, stomach discomfort, diarrhoea, erythra, scabies is overworked and dizzy.
Though the Chinese patent medicine of some treatment gastropathy is also arranged, as a kind of pharmaceutical composition for the treatment of gastropathy of Chinese patent application (patent No.: 98122151.3), be a kind of main treatment because of the Chinese patent medicine of stomach discomfort due to the peptic ulcer.It is the medicament of being made by the following weight proportion raw material: Endoconcha Sepiae 110-250 part, Radix Notoginseng 20-60 part, Rhizoma Corydalis 45-150 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 30-90 part, Fructus Amomi 15-50 part, Cortex Magnoliae Officinalis 20-80 part, Radix Aucklandiae 20-80 part, Lignum Aquilariae Resinatum 10-30 part, Rhizoma Alpiniae Officinarum 5-20 part, Radix Et Rhizoma Rhei 5-40 part, Bulbus Fritillariae Thunbergii 20-80 part.Though every kind of medicine of this patent application component all has the circulation of qi promoting hemostasis, the characteristics of warming spleen and stomach for dispelling cold, antacid granulation promoting, stomach function regulating, but combining and can not playing enhancing is the effect of medicine, so the effect of composition of medicine is not fairly obvious, the patient still has to rely on some Western medicine.
Summary of the invention
The object of the present invention is to provide a kind of stomach-benefiting medicine therapeutic agent that has treatment weakness of the spleen and stomach, essential resistance of turbid phlegm, stomach-QI being unable to descend normally and can alleviate gastritis, gastric ulcer, gastric cancer complication effect.
Another object of the present invention provides the preparation method of this rem.
Solution of the present invention is based on motherland's medical science to gastropathy and pathogenetic understanding of complication and Therapeutic Principle thereof, with reference to the modern pharmacological research achievement, from motherland's medicine treasure-house, filters out replenishing QI to invigorate the spleen, lets out hot and suffocating clearly; Burnt mechanism of qi among the Xuan Chang, it is clear and coherent that gastric qi is descended; Burnt expectorant is turbid in the change, hemostasis and pain-relieving; Profit stomach hemostasis helps spleen fortuneization, QI invigorating with in, coordinating the actions of various ingredients in a prescription.Simultaneously using both cold and hot drugs of the present invention, reinforcement and elimination in combination, bitter cold and do not upset one's stomach, happiness is evil and just do not hinder, both the regulating stomach-QI stomach is turbid, again can promoting the circulation of QI to relieve pain, the hardship of reduction of patient gastropathy is played important effect.
Medicine of the present invention is made by following component: (consumption is a weight portion)
Rhizoma Coptidis 4-18, Radix Ginseng Rubra 4-18, Bulbus Fritillariae Cirrhosae 4-18
Radix Notoginseng 5-26, Fructus Aurantii 4-18, Radix Aucklandiae (Radix Vladimiriae) 4-18,
Rhizoma Atractylodis Macrocephalae 5-25, Fructus Amomi Rotundus 4-20, Endothelium Corneum Gigeriae Galli 4-20,
Pseudobulbus Bletillae (Rhizoma Bletillae) 5-25, Endoconcha Sepiae 10-35, Radix Glycyrrhizae 3-15.
Formula optimization weight (part) ratio range of preparation medicine of the present invention is:
Rhizoma Coptidis 5～11 Radix Ginseng Rubra 5～11 Bulbus Fritillariae Cirrhosaes 5～11
Radix Notoginseng 6～18 Fructus Aurantiis 6～12 Radix Aucklandiae (Radix Vladimiriae) 6～12
Rhizoma Atractylodis Macrocephalae 6～12, Fructus Amomi Rotundus 6～12, Endothelium Corneum Gigeriae Galli 6～18
The Pseudobulbus Bletillae (Rhizoma Bletillae) 6～12, Endoconcha Sepiae 12～18, Radix Glycyrrhizae 3～6.
The optimum weight of medicine of the present invention (part) proportioning is:
Rhizoma Coptidis 8 Radix Ginseng Rubra 8 Bulbus Fritillariae Cirrhosaes 8
Radix Notoginseng 8 Fructus Aurantiis 8 Radix Aucklandiae (Radix Vladimiriae) 8
Rhizoma Atractylodis Macrocephalae 8, Fructus Amomi Rotundus 8, Endothelium Corneum Gigeriae Galli 8
The Pseudobulbus Bletillae (Rhizoma Bletillae) 8, Endoconcha Sepiae 16, Radix Glycyrrhizae 4.
In above-mentioned stomach-benefiting medicine, described medicament is the above a dosage form of any pharmaceutics; As preferably, described medicament is a powder.
Above-mentioned each component is made medicine production method of the present invention is:
1. got frying bitter orange earlier 2～6 minutes, drying and crushing to 120 order fine powder,
With Rhizoma Coptidis, Radix Ginseng Rubra, Bulbus Fritillariae Cirrhosae, Radix Notoginseng at-15 ℃ down respectively after the lyophilization, processing powder is broken into 120 order fineness;
3. extracting liquorice is crushed to 120 order fineness, is that 5% Diluted Alcohol solution extracts with concentration, discards residue, after extracting solution concentrates, and dry back and Fructus Aurantii powder, Rhizoma Coptidis powder, red ginseng powder, Bulbus Fritillariae Cirrhosae powder, Radix Notoginseng powder mixing; Make loose powder;
4. get Radix Aucklandiae (Radix Vladimiriae) Rhizoma Atractylodis Macrocephalae, Fructus Amomi Rotundus, Endothelium Corneum Gigeriae Galli, the Pseudobulbus Bletillae (Rhizoma Bletillae), Endoconcha Sepiae crushed after being dried and become 120 order fine powders;
With above-mentioned whole powder components by after the described mixed, 100～110 ℃ of following sterilization treatment 30～60 minutes, make powder.
In the preparation method of above-mentioned stomach-benefiting medicine: disinfecting action wherein is to adopt the step type sterilization, and temperature is raised to 110 ℃ rapidly, and segmentation drops to 100 ℃ then, sterilization time 30～60 minutes.
As preferably, disinfecting action wherein is the fine powder that will mix 110 ℃ of insulations 20 minutes down, cools to 105 ℃ then to keep 15 minutes, cools to 100 ℃ again and keeps 25 minutes.
Radix Ginseng Rubra wherein in the present invention, Rhizoma Atractylodis Macrocephalae replenishing QI to invigorate the spleen; The Rhizoma Coptidis bitter cold is let out hot and suffocating clearly; JUKE, burnt mechanism of qi during Radix Aucklandiae a surname is smooth, it is clear and coherent that gastric qi is descended; Fructus Amomi Rotundus, burnt expectorant is turbid in Endoconcha Sepiae, the Bulbus Fritillariae Cirrhosaeization, Radix Notoginseng energy hemostasis and pain-relieving; The hemostasis of Pseudobulbus Bletillae (Rhizoma Bletillae) profit stomach, Endothelium Corneum Gigeriae Galli helps spleen fortuneization, the Radix Glycyrrhizae QI invigorating with in, coordinating the actions of various ingredients in a prescription.The present invention makes medicament with the compositions of above-mentioned employing said medicine, and being based on potentiation is the drug combination pharmacological mechanism.Bring into play the synergism between medicine and improve curative effect; Drug combination has surpassed each medicine effect sum; The medicament simultaneously using both cold and hot drugs reinforcement and elimination in combination that the present invention is made, bitter cold and do not upset one's stomach, happiness is evil and just do not hinder, both the regulating stomach-QI stomach is turbid, again can promoting the circulation of QI to relieve pain, truly have the merit of stomach reinforcing, in addition powder not perishable, absorb very fast, taking convenience.
Therefore the present invention has the following advantages:
1. to select the homologous natural plants of medicated diet for use be raw material in the present invention, is drug combination pharmacological action mechanism treatment gastropathy based on potentiation on the pharmacology, do not have chemical sweeting agent, nontoxic to human body.
2. the present invention's phenomenon that has no adverse reaction can substitute Western medicine on therapeutic effect, and therapeutic effect is apparent in view, and can alleviate or eliminate other complication of gastropathy significantly.
3. the present invention need not decoct taking convenience.
Introduce acute toxicity testing, the anti-gastric-ulcer action effect of stomach-benefiting medicine preparation of the present invention below.
Acute toxicity test
With the SD rat of body weight 200 ± 20g, 10 every group, oral (3mg) or lumbar injection (1mg) stomach-benefiting medicine preparation of the present invention, administration was observed death condition after 7 days, obtained minimum fatal dose (MLD).The result is as shown in table 1.
Anti-gastric-ulcer effect test:
(body weight 180～220g) is carried out the anti-gastric-ulcer test with 18 hours SD male rat of fasting, water stress method be set up the gastric ulcer model of rat, it is 23 ± 1 ℃ Chi Shuizhong that the SD rat of oral pharmaceutical composition of the present invention is vertically put into temperature, put to death the SD rat with carbonic acid gas after 8 hours, get stomach, observe and measure the degree of injury of gastric gland portion with anatomical lens, summation is as the damage index of every SD rat.(this tests every group of 4～5 rats).
Treat reagent thing preparation with physiological saline solution, matched group is only given normal saline, and relatively two groups damage index is obtained suppression ratio and will be the results are shown in table 1 with following formula
Suppression ratio=(normal saline group-administration group)/normal saline group * 100
The pharmacological tests of table 1 The compounds of this invention
As shown in table 1, stomach-benefiting medicine of the present invention has good anti-gastric-ulcer effect, can be used as effective medicament for anti-gastric ulcer, and toxicity of the present invention is less.
The specific embodiment
Below by specific embodiment, technical scheme of the present invention is described in further detail; But the present invention is not limited to these embodiment
Percentage by weight proportioning by following tabulation takes by weighing following prescription
Table 2: the weight proportion (g) of embodiment 1～embodiment 5 each component
Table 3: the weight proportion (g) of embodiment 6～embodiment 10 each component
The production method of embodiment 1～10 is as follows
Got frying bitter orange earlier 2～6 minutes, drying and crushing to 120 order fine powder, after difference lyophilization under-15 ℃, processing powder is broken into 120 order fineness with Rhizoma Coptidis, Radix Ginseng Rubra, Bulbus Fritillariae Cirrhosae, Radix Notoginseng; Extracting liquorice is crushed to 120 order fineness, is that 5% Diluted Alcohol solution extracts with concentration, discards residue, after extracting solution concentrates, and dry back and Fructus Aurantii powder, Rhizoma Coptidis powder, red ginseng powder, Bulbus Fritillariae Cirrhosae powder, Radix Notoginseng powder mixing; Make loose powder; Get Radix Aucklandiae (Radix Vladimiriae) Rhizoma Atractylodis Macrocephalae, Fructus Amomi Rotundus, Endothelium Corneum Gigeriae Galli, the Pseudobulbus Bletillae (Rhizoma Bletillae), Endoconcha Sepiae crushed after being dried and become 120 order fine powders; By after the described mixed, 110 ℃ are incubated 20 minutes down, cool to 105 ℃ then to keep 15 minutes, cool to 100 ℃ again and keep 25 minutes with above-mentioned whole powder components.
Claims (8)
1, a kind of stomach-benefiting medicine is characterized in that it is the medicament of being made by the following weight proportion raw material
Rhizoma Coptidis 4-18, Radix Ginseng Rubra 4-18, Bulbus Fritillariae Cirrhosae 4-18
Radix Notoginseng 5-26, Fructus Aurantii 4-18, Radix Aucklandiae (Radix Vladimiriae) 4-18,
Rhizoma Atractylodis Macrocephalae 5-25, Fructus Amomi Rotundus 4-20, Endothelium Corneum Gigeriae Galli 4-20,
Pseudobulbus Bletillae (Rhizoma Bletillae) 5-25, Endoconcha Sepiae 10-35, Radix Glycyrrhizae 3-15.
2, stomach-benefiting medicine according to claim 1, wherein the weight proportion of each raw material is
Rhizoma Coptidis 5～11 Radix Ginseng Rubra 5～11 Bulbus Fritillariae Cirrhosaes 5～11
Radix Notoginseng 6～18 Fructus Aurantiis 6～12 Radix Aucklandiae (Radix Vladimiriae) 6～12
Rhizoma Atractylodis Macrocephalae 6～12, Fructus Amomi Rotundus 6～12, Endothelium Corneum Gigeriae Galli 6～18
The Pseudobulbus Bletillae (Rhizoma Bletillae) 6～12, Endoconcha Sepiae 12～18, Radix Glycyrrhizae 3～6.
3, stomach-benefiting medicine according to claim 1, wherein the weight proportion of each raw material is
Rhizoma Coptidis 8 Radix Ginseng Rubra 8 Bulbus Fritillariae Cirrhosaes 8
Radix Notoginseng 8 Fructus Aurantiis 8 Radix Aucklandiae (Radix Vladimiriae) 8
Rhizoma Atractylodis Macrocephalae 8, Fructus Amomi Rotundus 8, Endothelium Corneum Gigeriae Galli 8
The Pseudobulbus Bletillae (Rhizoma Bletillae) 8, Endoconcha Sepiae 16, Radix Glycyrrhizae 4.
4,, it is characterized in that described medicament is the above a dosage form of any pharmaceutics according to claim 1 or 2 or 3 described stomach-benefiting medicines.
5, stomach-benefiting medicine according to claim 4 is characterized in that described medicament is a powder.
6, according to the preparation method of the described stomach-benefiting medicine of claim 5, it is characterized in that getting earlier frying bitter orange 2～6 minutes, drying and crushing to 120 order fine powder, after difference lyophilization under-15 ℃, processing powder is broken into 120 order fineness with Rhizoma Coptidis, Radix Ginseng Rubra, Bulbus Fritillariae Cirrhosae, Radix Notoginseng; Extracting liquorice is crushed to 120 order fineness, is that 5% Diluted Alcohol solution extracts with concentration, discards residue, after extracting solution concentrates, and dry back and Fructus Aurantii powder, Rhizoma Coptidis powder, red ginseng powder, Bulbus Fritillariae Cirrhosae powder, Radix Notoginseng powder mixing; Make loose powder; Get Radix Aucklandiae (Radix Vladimiriae) Rhizoma Atractylodis Macrocephalae, Fructus Amomi Rotundus, Endothelium Corneum Gigeriae Galli, the Pseudobulbus Bletillae (Rhizoma Bletillae), Endoconcha Sepiae crushed after being dried and become 120 order fine powders; Above-mentioned whole powder components by after the described mixed, 100～110 ℃ of following sterilization treatment 30～60 minutes, are made powder.
7, the preparation method of stomach-benefiting medicine according to claim 6, disinfecting action wherein are to adopt the step type sterilization, and temperature is raised to 110 ℃ rapidly, and segmentation drops to 100 ℃ then, sterilization time 30～60 minutes.
8. the preparation method of stomach-benefiting medicine according to claim 6, disinfecting action wherein are the fine powders that will mix 110 ℃ of insulations 20 minutes down, cool to 105 ℃ then to keep 15 minutes, cool to 100 ℃ again and keep 25 minutes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100606328A CN1299756C (en) | 2005-09-05 | 2005-09-05 | Stomach-benefiting medicine and its prepn |
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|---|---|---|---|
| CNB2005100606328A CN1299756C (en) | 2005-09-05 | 2005-09-05 | Stomach-benefiting medicine and its prepn |
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| CN1739760A true CN1739760A (en) | 2006-03-01 |
| CN1299756C CN1299756C (en) | 2007-02-14 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103494963A (en) * | 2013-10-09 | 2014-01-08 | 颜文超 | Special medicated diet for treating stomach cancer |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1066062C (en) * | 1998-03-24 | 2001-05-23 | 宋青 | Medicine for gastroenteritic diseases and its preparation process |
| CN1150021C (en) * | 2001-01-09 | 2004-05-19 | 刘宝泉 | Chinese patent medicine for treating peptic ulcer |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103494963A (en) * | 2013-10-09 | 2014-01-08 | 颜文超 | Special medicated diet for treating stomach cancer |
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| CN1299756C (en) | 2007-02-14 |
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Granted publication date: 20070214 |