CN1738900B - 特异于胰腺胰岛β细胞的蛋白质及其应用 - Google Patents

特异于胰腺胰岛β细胞的蛋白质及其应用 Download PDF

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CN1738900B
CN1738900B CN2003801088861A CN200380108886A CN1738900B CN 1738900 B CN1738900 B CN 1738900B CN 2003801088861 A CN2003801088861 A CN 2003801088861A CN 200380108886 A CN200380108886 A CN 200380108886A CN 1738900 B CN1738900 B CN 1738900B
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cell
polynucleotide
protein
seq
present
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CN1738900A (zh
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米歇尔·塞夫
阿兰·法维耶
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Joseph fourier university
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
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Commissariat a lEnergie Atomique CEA
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
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  • Biotechnology (AREA)
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  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Public Health (AREA)
CN2003801088861A 2002-11-18 2003-11-18 特异于胰腺胰岛β细胞的蛋白质及其应用 Expired - Fee Related CN1738900B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR02/14374 2002-11-18
FR0214374A FR2847263B1 (fr) 2002-11-18 2002-11-18 Polynucleotide specifique de la cellule pancreatique beta des ilots de langerhans
PCT/FR2003/003413 WO2004046355A2 (fr) 2002-11-18 2003-11-18 Proteine specifique des cellules pancreatiques beta des ilots de langerhans et ses applications.

Related Child Applications (1)

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CN2011101575572A Division CN102250242A (zh) 2002-11-18 2003-11-18 特异于胰腺胰岛β细胞的蛋白质及其应用

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CN1738900A CN1738900A (zh) 2006-02-22
CN1738900B true CN1738900B (zh) 2011-07-06

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CN2011101575572A Pending CN102250242A (zh) 2002-11-18 2003-11-18 特异于胰腺胰岛β细胞的蛋白质及其应用

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US (2) US7851164B2 (https=)
EP (3) EP1563071B1 (https=)
JP (2) JP4498144B2 (https=)
CN (2) CN1738900B (https=)
AT (2) ATE494376T1 (https=)
AU (1) AU2003295025B2 (https=)
CA (1) CA2506331C (https=)
DE (2) DE60323664D1 (https=)
DK (2) DK1925667T3 (https=)
ES (3) ES2314268T3 (https=)
FR (1) FR2847263B1 (https=)
WO (1) WO2004046355A2 (https=)

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WO2008065544A2 (en) * 2006-09-11 2008-06-05 Mcgill University Genetic predictors of risk for type 2 diabetes mellitus
EP2118309B1 (en) * 2006-12-29 2015-01-28 The Regents of the University of Colorado, a body corporate Diagnostic and therapeutic target for autoimmune diseases and uses thereof
WO2008096009A2 (en) * 2007-02-09 2008-08-14 Mellitech Polymorphism in the slc30a8 gene
WO2009101181A2 (en) * 2008-02-14 2009-08-20 Universite Libre De Bruxelles New plasma membrane biomarkers preferentially expressed in pancreatic beta cells useful in imaging or targeting beta cells
CN102171242A (zh) * 2008-09-30 2011-08-31 诺沃-诺迪斯克有限公司 G6PC2编码的β细胞表面标签
WO2010054096A1 (en) * 2008-11-07 2010-05-14 The Cleveland Clinic Foundation Method for detecting and purifying pancreatic beta cells
CN102762731B (zh) * 2009-08-05 2018-06-22 库尔纳公司 通过抑制针对胰岛素基因(ins)的天然反义转录物来治疗胰岛素基因(ins)相关的疾病
EP2537859A1 (en) 2011-06-23 2012-12-26 Université de Mons Molecules specifically binding pancreatic beta cells biomarkers
US8852873B2 (en) 2012-04-13 2014-10-07 Diabetomics, Llc Maternal biomarkers for gestational diabetes
CN104098675A (zh) * 2013-04-03 2014-10-15 苏州偲聚生物材料有限公司 多肽、包含该多肽的检测器件和检测试剂盒
CN104098673A (zh) * 2013-04-03 2014-10-15 苏州偲聚生物材料有限公司 多肽、包含该多肽的检测器件和检测试剂盒
JP6825910B2 (ja) * 2014-03-26 2021-02-03 ヘルムホルツ・ツェントルム・ミュンヒェン・ドイチェス・フォルシュンクスツェントルム・フューア・ゲズントハイト・ウント・ウムベルト（ゲーエムベーハー）Ｈｅｌｍｈｏｌｔｚ Ｚｅｎｔｒｕｍ Ｍｕｅｎｃｈｅｎ Ｄｅｕｔｓｃｈｅｓ Ｆｏｒｓｃｈｕｎｇｓｚｅｎｔｒｕｍ ｆｕｅｒ Ｇｅｓｕｎｄｈｅｉｔ ｕｎｄ Ｕｍｗｅｌｔ （ＧｍｂＨ） Ｆｌａｔｔｏｐ（Ｆｌｔｐ）はβ細胞成熟についての新規のバイオマーカーである
GB201520568D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd Peptides
GB201520550D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520603D0 (en) * 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
WO2017189483A1 (en) 2016-04-25 2017-11-02 The Johns Hopkins University Znt8 assays for drug development and pharmaceutical compositions
CN106226526A (zh) * 2016-06-30 2016-12-14 深圳市亚辉龙生物科技股份有限公司 一种锌转运蛋白8抗体化学发光免疫检测试剂盒及其制备方法
EP3652540A4 (en) 2017-07-12 2021-04-07 The Johns Hopkins University PROTEOLIPOSOME-BASED ZNT8 SELF-ANTIGEN FOR DIAGNOSIS OF TYPE 1 DIABETES
WO2020037174A1 (en) * 2018-08-16 2020-02-20 The Johns Hopkins University Antibodies to human znt8
CN109734793B (zh) * 2019-03-14 2022-12-02 深圳市药品检验研究院（深圳市医疗器械检测中心） 一种ZnT8重组蛋白及其制备方法和应用
US20220340911A1 (en) * 2019-08-13 2022-10-27 Amgen Inc. Rnai constructs for inhibiting slc30a8 expression and methods of use thereof
US12366570B2 (en) 2019-10-01 2025-07-22 The Johns Hopkins University Cell-based ZNT8 assay
CA3228876A1 (en) 2021-08-20 2023-02-23 Dax Fu Cell-surface antibody to a specific biomarker of pancreatic beta-cells

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Also Published As

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ES2314268T3 (es) 2009-03-16
CA2506331A1 (fr) 2004-06-03
WO2004046355A2 (fr) 2004-06-03
US7851164B2 (en) 2010-12-14
ATE408689T1 (de) 2008-10-15
EP2239272A3 (fr) 2010-12-08
EP1563071A2 (fr) 2005-08-17
DK1563071T3 (da) 2009-02-02
AU2003295025B2 (en) 2008-09-18
ES2454592T3 (es) 2014-04-11
JP2010150262A (ja) 2010-07-08
DE60335676D1 (de) 2011-02-17
ES2361639T3 (es) 2011-06-20
EP1925667A1 (fr) 2008-05-28
CN102250242A (zh) 2011-11-23
DE60323664D1 (de) 2008-10-30
JP4498144B2 (ja) 2010-07-07
JP5202550B2 (ja) 2013-06-05
AU2003295025A1 (en) 2004-06-15
CA2506331C (fr) 2015-02-17
FR2847263A1 (fr) 2004-05-21
JP2006506084A (ja) 2006-02-23
EP1925667B1 (fr) 2011-01-05
EP2239272A2 (fr) 2010-10-13
FR2847263B1 (fr) 2006-01-13
WO2004046355A3 (fr) 2004-09-30
DK1925667T3 (da) 2011-04-26
EP2239272B1 (fr) 2014-01-01
US20110027807A1 (en) 2011-02-03
ATE494376T1 (de) 2011-01-15
EP1563071B1 (fr) 2008-09-17
US9568482B2 (en) 2017-02-14
US20060246442A1 (en) 2006-11-02
CN1738900A (zh) 2006-02-22

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