CN1724007A - Medicine contg. zinc, honeysuckle, Radix scutellariae and forsynthia fruit - Google Patents
Medicine contg. zinc, honeysuckle, Radix scutellariae and forsynthia fruit Download PDFInfo
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- CN1724007A CN1724007A CN 200410043729 CN200410043729A CN1724007A CN 1724007 A CN1724007 A CN 1724007A CN 200410043729 CN200410043729 CN 200410043729 CN 200410043729 A CN200410043729 A CN 200410043729A CN 1724007 A CN1724007 A CN 1724007A
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Abstract
A Chinese medicine 'Zn-contained Shuanghuanglian' for treating the bactenal and viral upper respiratory tract infection is prepared proportionally from honeysuckle flower, scutellaria root, forsythia fruit and Zn preparation. Its preparing process is also disclosed.
Description
Technical field: the present invention relates to a kind of zinc SHUANGHUANLIAN and Preparation Method thereof of containing, the prescription preparation contains zinc SHUANGHUANLIAN medicine especially according to Chinese medicine Coordinative Chemistry theory and again.
Background technology: at present, the SHUANGHUANLIAN product of market listing has products such as aqueous injection, injectable powder, granule, capsule, tablet and oral liquid.It is by Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae three flavor Chinese prescriptions that its raw material is formed, and reuses Fructus Forsythiae and wants as monarch.But the patient of upper respiratory tract infection increases to some extent in recent years, and majority is mixed infection viral and antibacterial, and 'Shuang Hualian ' bacteriostasis deficiency is treated as simple use SHUANGHUANLIAN, and it is longer the course of treatment to exist treatment, and curative effect is hanged down and waited deficiency.If cooperate the then more remarkable (Lin Bin of curative effect of appropriate antibacterial drug therapy.Deng.Shuanghuanglian powder injection and cefazolin sodium 5 usefulness effect mechanism researchs.China Dispensary.2000,11 (1): 18), promptly 5 usefulness can strengthen SHUANGHUANLIAN and antibiotic bacteriostasis simultaneously, and SHUANGHUANLIAN and antibiotic share anti-infective therapy course of treatment is shortened, and curative effect improves, and with single with there were significant differences (Chen Shuanlu, the Lu Guojin of a kind of medicine wherein.The research [J] of bacteriostatic activity outside ZHUSHEYONG SHUANGHUANGLIAN and several antibiotic association.Contemporary Chinese is used pharmaceutical journal.1998，15(8)：58)。
Summary of the invention: in order to overcome existing 'Shuang Hualian ' bacteriostasis deficiency, the invention provides a kind of zinc SHUANGHUANLIAN medicine that contains, this contains zinc SHUANGHUANLIAN medicine can not only improve bacteriostasis, and has the thermal effect of separating that can significantly improve its reduction body temperature.Technical scheme of the present invention is: medicine of the present invention is to make (ratio of weight and number) by following medicine and component: Flos Lonicerae 2.5-6.5 part; Radix Scutellariae 2.5-6.5 part; Fructus Forsythiae 5.0-12.0 part; Containing zinc is the zinc agent of 0.015-0.075 part.
The preparation method of medicine of the present invention is:
1, gets Fructus Forsythiae earlier and go into to boil in 6 times the water 10 minutes, drop into Flos Lonicerae, Radix Scutellariae, stop heating after 10 minutes, place, when temperature is reduced to 50 ℃, add ethanol and make and contain the alcohol amount and reach 50% determining alcohol;
2, with above-mentioned gained medicinal liquid pour in the KS-500D ultrasonic washing unit that the gauze string bag is housed, 40 (KHz) ultrasonic extraction 45 minutes (40 ℃ of temperature), altogether ultrasonic extraction is 2 times.Combining extraction liquid, sucking filtration, filtrate recycling ethanol (decompression) is evaporated to 1.20-1.25 (70-80 ℃ of survey), and vacuum drying (50 ℃) gets extract powder;
3, with the above-mentioned SHUANGHUANLIAN extract powder that makes by described proportioning with after the zinc agent mixes, promptly.
Solution of the present invention is based on modern pharmacology to the new thinking of Chinese medicine active chemical research and the new knowledge of Chinese medicine Coordinative Chemistry theory thereof.On the basis of the former prescription of SHUANGHUANLIAN, increase harmonizing drug zinc agent simply.The zinc agent can be adopted taurine zinc; contain taurine in the zinc and have refrigeration function because of taurine closes; can at short notice hyperpyrexia infant body temperature be reduced to normally; curative effect is lasting; there is not knock-on; can suppress the inflammation that the staphylococcus escherichia coli are caused, viral infection is also had good inhibition effect (DuBing Zhen, Hu Kangxing.Taurine granule therapy children's acute respiratory tract infection observation of curative effect. Chinese rural medical magazine.2003，10(10)：36)。(Li Chunlian, etc.Taurine granule assistant is controlled bronchopneumonia 120 routine clinical observations.Modern combination of Chinese and Western medicine magazine .2003,12 (14): 1509).And wherein contained zinc can make Flos Lonicerae water extract bacteriostasis when having zinc to exist significantly improve (Cao Zhiquan, room analogy.New thinking to the research of Chinese medicine active chemical. practical combination of Chinese and Western medicine magazine, 1991,4 (9): 520).Experiment shows that Baicalin-Zn BA-Zn ZnBA has certain inhibitory action (suppression ratio 22.41%) to the experimental edema of dimethyl benzene.It only is not 12.23% and 10.41% that the simple baicalin or the suppression ratio of zinc chloride reach.Baicalin-Zn BA-Zn ZnBA is to the existing significantly influence of sensitized guinea pig isolated organ Schultz-DaleShi reaction, and the suppression ratio of Baicalin-Zn BA-Zn ZnBA is 68.31 ± 9.56%, and the suppression ratio of baicalin be 35.70 ± 6.84% (Jia Xiurong, etc.The northwest pharmaceutical journal.1994，9(4)：162)。So we are antibacterial, antiinflammatory, the antipyretic ability that harmonizing drug strengthens chlorogenic acid in the SHUANGHUANLIAN, caffeic acid, rutin, phillyrin, baicalin, baicalin with the zinc agent, the purpose of raising clinical efficacy.Clinical drug result on trial of the present invention shows that containing the zinc SHUANGHUANGLIAN JIAONANG is a kind of antipyretic and anti-inflammatory medicine of highly effective and safe, and the clinical symptom remission rate is than SHUANGHUANLIAN obviously raise (P＜0.01).
Medicine of the present invention can be avoided selecting appropriate antibiotic difficulty with 5 times spent of antibiotic, and the benefit of untoward reaction such as avoiding generation of flora drug resistance and antibiotics toxic and side effect is arranged.And it is simple to have preparation method, can energy savings, characteristics such as reduce production costs, the zinc that another important feature of the present invention is in this product and is contained is one of 14 kinds of essential in human body trace element, have important biological function, can influence growth promoter, improving appetite and digestive function, the enhancing human body immunity function is arranged, prevent important function such as flu.Contained taurine also is a kind of aminoacid with extensive biological action in this product; functions such as unique antiinflammatory, analgesia, analgesic calmness, blood pressure lowering are arranged, especially the baby's brain after the wean, vision, height and body weight are grown the crucial effect that plays.
Be the clinical experiment result below:
The clinical observation purpose:
Observation contains the clinical refrigeration function of zinc SHUANGHUANGLIAN JIAONANG, antiinflammatory action, side effect and the suitableeest clinical treatment dosage.
Observe medicine:
Curative: the zinc SHUANGHUANGLIAN JIAONANG that contains of the present invention, five rings, Mudanjiang pharmaceutical Co. Ltd produces, specification: 0.3g/ grain.
The contrast medicine: SHUANGHUANGLIAN KOUFUYE, Harbin No.3 Traditional Chinese Medicine Factory produces.
Case is selected:
1. determine the selection of minimum effective dose case:
Case is selected: select the above heating of growing up of 15 one full year of life to be diagnosed as viral respiratory tract infection patient 60 examples, the men and women all can.
The sick kind: viral upper respiratory tract infection, tracheitis, bronchitis, pneumonia, the degree of heat is more than 37.5 ℃.
Medicine group 30 examples, control drug group 30 examples, equal twice oral zinc SHUANGHUANGLIAN JIAONANG and control drug of containing.Each is organized the case distribution and is undertaken by district's group random table.
Observation index:
Body temperature: took medicine back 1 hour, 3 hours, 5 hours, 7 hours, 12 hours, 24 hours, and surveyed body temperature decline situation.
Symptom and sign: took medicine back 7 hours, 12 hours, 24 hours, viewing head, pharynx, breast, extremity portion pain, pharyngeal congestion, cough, expectoration,, breathe heavily, uncomfortable in chest, breathe hard, dyspnea symptom sign alleviates situation.
The back 24 hours patient temperatures of taking medicine drop to below 37 ℃ and (comprise 37 ℃), head, pharynx, breast, extremity portion pain, pharyngeal congestion, cough, expectoration,, breathe heavily, uncomfortable in chest, breathe hard, dyspnea symptom sign alleviates situation such as non-evident effect and untoward reaction, and this dosage promptly is defined as minimum effective dose.
2. case is selected:
Age: children's, from child's to 14 one full year of life, the men and women does not limit.Observation group's (containing zinc SHUANGHUANGLIAN JIAONANG group) 60 examples, positive controls (SHUANGHUANLIAN group) 30 examples.The adult, above adult of 15 one full year of life, the men and women all can.Observation group's (containing zinc SHUANGHUANGLIAN JIAONANG group) 60 examples, positive controls (SHUANGHUANLIAN group) 30 examples.
Each is organized the case distribution and is undertaken by the 2:1 random table.
The sick kind: ill toxicity respiratory system infection, heating, head, pharynx, breast, extremity portion pain, pharyngeal congestion, cough, expectoration,, breathe heavily, uncomfortable in chest, breathe hard dyspnea symptom sign person more than a day.
The degree of heat: basic, normal, high heat, press internal medicine diagnostic base specified standard.The low grade fever case load must not be organized 1/3rd of routine number above this in each group, and the hyperpyrexia number must not be organized 1/3rd of routine number less than this.
Points for attention and eliminating case:
1. respectively organize disease kind, age, sex and answer there was no significant difference.
2. forbid taking simultaneously other types antipyretic, adrenocortical hormone.
3. forbid taking anti-other Chinese and western drugses that cure cold.
Dosage and method:
1. children's observation group: contain zinc SHUANGHUANGLIAN JIAONANG 2-4 grain d,
Positive controls: SHUANGHUANGLIAN KOUFUYE 10ml, 30ml/d.
Adult observation group: contain zinc SHUANGHUANGLIAN JIAONANG 4-6 grain d.
Positive controls: SHUANGHUANGLIAN KOUFUYE 30ml/d.
Below respectively organizing dose divides every day 2-3 time oral.
Each group is all in taking medicine back 1 hour, 3 hours, 5 hours, 7 hours, 12 hours, 24 hours first, survey body temperature, viewing head, pharynx, breast, extremity portion pain, pharyngeal congestion, cough, expectoration,, breathe heavily, uncomfortable in chest, breathe hard, dyspnea symptom sign alleviates situation, being recorded to takes medicine ended in back 24 hours, side effect and untoward reaction are recorded to after the drug withdrawal 3 days, and objective indicator is in the check in 3 days～7 days of taking medicine.
Effectively criterion:
1. patient's a certain moment body temperature of taking medicine in back 8 hours all drops to and (comprises 37 ℃) below 37 ℃ for effectively.
2. taking medicine, a certain moment body temperature descends 1 ℃, 2 ℃ in back 8 hours, and the summation of the positive hundreds of proportions by subtraction of common practice reaches 90% or more for effective.
3. taking medicine, a certain moment body temperature descends 2 ℃ in back 8 hours, and the summation of the positive hundreds of proportions by subtraction of common practice reaches 90% or more for effective.
4. sings and symptoms such as a certain moment fever alleviation 85% is effective in 24 hours.Above standard meets and wherein is more than 1 or 1 effectively.
Observation index:
Body temperature and every observation index are seen attached list.
Statistical summary:
Each group is preceding by taking medicine, take medicine the back each constantly body temperature do the t check, take medicine between each group the back each constantly body temperature do the t check, each group each body temperature decline percentage rate constantly of back of taking medicine.Each organizes remission degree percentage rate.Side effect and untoward reaction are analyzed, drawn whether untoward reaction and side effect are arranged, and item, the scope of application and the consumption usage noted.
The result
Subordinate list 1 contains the clinical observation of the analgesic capsule effect of zinc SHUANGHUANLIAN
The adult children's
Contain zinc SHUANGHUANGLIAN JIAONANG SHUANGHUANLIAN and contain zinc SHUANGHUANLIAN SHUANGHUANLIAN
Capsule
(n＝60) (n＝30) (n＝60) (n＝60)
Take medicine preceding body temperature (℃) 38.5 ± 0.6 38.3 ± 0.6 39.3 ± 0.25 39.2 ± 0.3
Clothes (hour) 1 38.5 ± 0.5 38.3 ± 0.35 39.0 ± 0.3 39.1 ± 0.26
Medicine 2 38.1 ± 0.5 38.2 ± 0.45 39.0 ± 0.5 39.1 ± 0.5
Back 3 38.0 ± 0.3 38.2 ± 0.6 38.7 ± 0.4 38.8 ± 0.6
Each is 5 37.5 ± 0.4 38.0 ± 0.4 38.2 ± 0.5 38.7 ± 0.45 years old
The time 7 37.1 ± 0.5 37.6 ± 0.5 37.5 ± 0.35 38.1 ± 0.4
Carve 36.7 ± 0.6 37.4 ± 0.4 36.8 ± 0.4 37.8 ± 0.5
12 36.7±0.4
Body 37.5 ± 0.5 36.7 ± 0.35 37.4 ± 0.4
24
Temperature (℃)
Annotate: the preceding adult that takes medicine, children's contain zinc SHUANGHUANLIAN and SHUANGHUANLIAN group body temperature zero difference.Take medicine back 5 hours adults, children's contain the preceding decline of taking medicine of zinc SHUANGHUANLIAN and SHUANGHUANLIAN group body temperature, contain zinc SHUANGHUANLIAN group body temperature descend obviously (P＜0.05).Obviously descend (P＜0.01) before adult, children's contain zinc SHUANGHUANLIAN and SHUANGHUANLIAN group body temperature and take medicine after taking medicine 24 hours, contain zinc SHUANGHUANLIAN group descend remarkable (P＜0.01).
Subordinate list 2 adults contain zinc SHUANGHUANLIAN and SHUANGHUANLIAN refrigeration function percentage rate
Each moment body temperature drops to normal percentage rate
1 2 3 5 7 12 24 (h)
Contain zinc SHUANGHUANLIAN 16 20 41.7
a59.6
a61.3
a80.7
a90.2
a
Capsule
SHUANGHUANLIAN 10 14 21.7 31.2 40.7 50.1 70.7
Annotate: two groups relatively
aCalculate with the routine number that body temperature drops to below 37 ℃ P＜0.05
It is obvious than the SHUANGHUANLIAN refrigeration function to contain the zinc SHUANGHUANGLIAN JIAONANG
Subordinate list 3 children's contain zinc SHUANGHUANLIAN and SHUANGHUANLIAN refrigeration function percentage rate
Each moment body temperature drops to normal percentage rate
1 2 3 5 7 12 24 (h)
Contain zinc SHUANGHUANLIAN 3 19 30
a85.7
b90.1
b90.5
b95.1
b
Capsule
SHUANGHUANLIAN 09 30 30 45.1 50.1 70.1
Annotate: two groups relatively
aP＜0.05,
bP＜0.01 drops to routine number below 37 ℃ with body temperature and calculates that to contain the zinc SHUANGHUANGLIAN JIAONANG obvious than the SHUANGHUANLIAN refrigeration function
Table 4 contains zinc SHUANGHUANGLIAN JIAONANG, 12,24 hours clinical symptom remission percentage rate of SHUANGHUANLIAN
12 24 (h)
Contain zinc SHUANGHUANGLIAN JIAONANG 95.9 70.8
SHUANGHUANLIAN 89.7 40.7
Contain zinc SHUANGHUANGLIAN JIAONANG clinical symptom remission rate than SHUANGHUANLIAN obviously raise (P＜0.01).
Two groups of patients there is no clinical adverse.
Conclusion: containing the zinc SHUANGHUANGLIAN JIAONANG is a kind of antipyretic and anti-inflammatory medicine of highly effective and safe.
Annotate: 1. observe the medicine letter and represent that with T, C T is for containing the zinc SHUANGHUANGLIAN JIAONANG, C is a SHUANGHUANGLIAN KOUFUYE.
2. every usefulness in all brackets+,-number represent.
3. the unit in the observation item is by iu.
The specific embodiment 1: take by weighing raw material: 4.5 parts of Flos Loniceraes by following proportioning; 4.5 parts of Radix Scutellariaes; 9.0 parts of Fructus Forsythiaes; Contain zinc and be 0.025 part taurine zinc; Be extracting honeysuckle 450g; Radix Scutellariae 450g; Fructus Forsythiae 900g; Taurine zinc 120g;
Preparation method is as follows: preparation of the present invention can be a said dosage form on any pharmaceutics.Adopt capsule in the present embodiment.
Get Fructus Forsythiae earlier and go in the water of 6 times of amounts (volume) to boil 10 minutes, drop into Flos Lonicerae and Radix Scutellariae again, stop heating after 10 minutes, place, when temperature is reduced to 50 ℃, add ethanol and make and contain the alcohol amount and reach 50% determining alcohol; That continues will all pour in the KS-500D ultrasonic washing unit that the gauze string bag is housed with medicine-feeding, liquid, and 40 (KHz) ultrasonic extraction 45 minutes (40 ℃ of temperature) surpasses 2 times altogether.Combining extraction liquid, sucking filtration continues to be evaporated to relative density 1.20--1.25 (70--80 ℃ of survey) behind the decompression filtrate recycling ethanol, and vacuum drying (50 ℃) gets extract powder; After pressing proportioning raw materials and taurine zinc mixing, pack the 0.3g capsule into promptly.
The specific embodiment 2: take by weighing raw material: Flos Lonicerae 450g by following proportioning; Radix Scutellariae 450g; Fructus Forsythiae 900g, zinc gluconate 174g, preparation method is as follows: get Fructus Forsythiae earlier and go in the water of 6 times of amounts (volume) to boil 10 minutes, drop into Flos Lonicerae and Radix Scutellariae again, stop heating after 10 minutes, place, when temperature is reduced to 50 ℃, add ethanol and make and contain the alcohol amount and reach 50% determining alcohol; That continues all pours above medicinal liquid in the KS-500D ultrasonic washing unit that the gauze string bag is housed, and 40 (KHz) ultrasonic extraction 45 minutes (40 ℃ of temperature) surpasses 2 times altogether.Combining extraction liquid, sucking filtration continues to be evaporated to relative density 1.20-1.25 (70--80 ℃ of survey) behind the decompression filtrate recycling ethanol, and vacuum drying (50 ℃) gets extract powder; After pressing proportioning raw materials and zinc gluconate mixing, promptly.
The specific embodiment 3:
Take by weighing raw material by following proportioning: Flos Lonicerae 450g, Radix Scutellariae 450g, Fructus Forsythiae 900g zinc sulfate 109.9g, preparation method is as follows: get Fructus Forsythiae earlier and go in the water of 6 times of amounts (volume) to boil 10 minutes, drop into Flos Lonicerae and Radix Scutellariae again, stop heating after 10 minutes, place, when temperature is reduced to 50 ℃, add ethanol and make and contain the alcohol amount and reach 50% determining alcohol; That continues all pours above medicinal liquid in the KS-500D ultrasonic washing unit that the gauze string bag is housed, 40 (KHz) ultrasonic extraction 45 minutes (40 ℃ of temperature), surpass altogether 2 times, combining extraction liquid, sucking filtration, continue to be evaporated to relative density 1.20--1.25 (70--80 ℃ of survey) behind the decompression filtrate recycling ethanol, vacuum drying (50 ℃) gets extract powder; After pressing proportioning raw materials and zinc sulfate mixing, pack the 0.3g capsule into promptly.
Claims (5)
1, a kind of zinc SHUANGHUANLIAN medicine that contains is characterized in that it is to be made by the following raw medicaments in portion by weight thing: Flos Lonicerae 2.5---12.0 parts of 6.5 parts, Radix Scutellariaes 2.5---6.5 parts, Fructus Forsythiae 5.0---, and containing zinc is 0.015---0.075 part zinc agent.
2, the zinc SHUANGHUANLIAN medicine that contains as claimed in claim 1 is characterized in that the weight fraction ratio of described crude drug is: 4.5 parts of Flos Loniceraes, 4.5 parts of Radix Scutellariaes, 9.0 parts of Fructus Forsythiaes, contain the zinc agent of 0.025 part on zinc.
3, the zinc SHUANGHUANLIAN medicine that contains as claimed in claim 1, the zinc agent that it is characterized in that wherein being contained can be any zinc agent of closing the zinc form.
4, the zinc SHUANGHUANLIAN medicine that contains as claimed in claim 1 is characterized in that described zinc agent is a taurine zinc.
5,, it is characterized in that described dosage form can be any preparation formulation on the pharmaceutics as the described zinc SHUANGHUANLIAN medicine that contains of claim 1.2.3.4.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100437293A CN1322874C (en) | 2004-07-19 | 2004-07-19 | Medicine contg. zinc, honeysuckle, Radix scutellariae and forsynthia fruit |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100437293A CN1322874C (en) | 2004-07-19 | 2004-07-19 | Medicine contg. zinc, honeysuckle, Radix scutellariae and forsynthia fruit |
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| Publication Number | Publication Date |
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| CN1724007A true CN1724007A (en) | 2006-01-25 |
| CN1322874C CN1322874C (en) | 2007-06-27 |
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| CN105193948A (en) * | 2015-10-29 | 2015-12-30 | 林州中农生物肽科技有限公司 | Preparation method of Shuanghuanglian oral liquid for animals |
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| US7745509B2 (en) | 2003-12-05 | 2010-06-29 | 3M Innovative Properties Company | Polymer compositions with bioactive agent, medical articles, and methods |
| US8399027B2 (en) | 2005-04-14 | 2013-03-19 | 3M Innovative Properties Company | Silver coatings and methods of manufacture |
| US20070166399A1 (en) | 2006-01-13 | 2007-07-19 | 3M Innovative Properties Company | Silver-containing antimicrobial articles and methods of manufacture |
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| CN1089848A (en) * | 1993-01-15 | 1994-07-27 | 哈尔滨中药四厂 | SHUANGHUANGLIAN JIAONANG and preparation method thereof |
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| CN105193948A (en) * | 2015-10-29 | 2015-12-30 | 林州中农生物肽科技有限公司 | Preparation method of Shuanghuanglian oral liquid for animals |
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