CN1504231A - Medicine for tumour - Google Patents

Abstract

The invention discloses a medicament for treating neoplastic diseases which comprises oldenlandia, cactus, Leucophysalis Makino, pericarpium trichosanthis, seed of cowherb, astragalus root, root of red rooted saliva, poria cocos wolf, barbat skullcap, curcuma aromatica, Chinese angelica root and bitter gourd. The advantage of the invention is unique formulation and high curative effect.

Description

A kind of medicine for the treatment of tumor disease

It is 02153714.3 application for a patent for invention priority that the present invention requires number of patent application, and the applying date is December in 2002 2 days, and denomination of invention is: a kind of medicine for the treatment of tumor disease

Invention field

The present invention relates to a kind of medicine for the treatment of tumor disease.It specifically is the Chinese patent medicine of feedstock production with the Chinese herbal medicine.

Background technology

Tumor disease is the common frdquently encountered disease of serious harm human health, and its mortality rate that causes is high, is positioned at first of the human diseases mortality rate, only sees with regard to the situation of China that annual newfound tumor patients in heilongjiang is up to more than 180 ten thousand people.Therefore, people are being devoted to treat the research of tumor disease medicine always.

At present, Western medicine runs into following problem to the tumor disease Drug therapy both at home and abroad:

1, curative effect of medication is low, side effect is big, and clothes easily cause the body visceral organ injury for a long time;

2, drug quality instability, the cost height.

Though the Chinese patent medicine of some treatment tumor diseases is also arranged, because effect is not fairly obvious, the patient still has to depend on some Western medicine.

Summary of the invention

The purpose of this invention is to provide a kind of tumor disease therapeutic agent, it has the tumor of not diffusion such as thyroid carcinoma, esophageal carcinoma, hepatocarcinoma, rectal cancer, breast carcinoma, uterus carcinoma, bone carcinoma gigantocellulare, lymph glands Carcinoma, the brain cancer etc. and suppresses and the elimination effect, to the patient of underwent operative and radiotherapy chemotherapy, significant rehabilitative action is arranged.

Solution of the present invention is based on understanding and the Therapeutic Principle of motherland's medical science to tumor disease mechanism, achieve with reference to modern pharmacological research, from motherland's medicine treasure-house, filter out nourishing kidney-yin, QI invigorating void, blood stasis dispelling blood, pure and impurely let out, strengthening the body resistance, the homologous natural plant of medicated diet, by monarch, the minister of the traditional Chinese medical science, help, make principle to carry out prescription, increase body biological activity and immune resistance, improve organ function, suppress and the elimination tumor cell.

The present invention is achieved through the following technical solutions:

Medicine of the present invention is the medicament of being made by following raw material: (consumption is a weight portion)

Agkistrodon snakeweed 10-50 Radix et Caulis Opuntiae Dillenii 20-60

Radix Ardisiae Punctatae grass 5-20 Fructus Trichosanthis 10-60

Semen Vaccariae 50-150 Radix Astragali 20-100

Pseudobulbus Cremastrae seu Pleiones 5-30 Radix Salviae Miltiorrhizae 10-60

Poria 15-60 Herba Scutellariae Barbatae 20-80

Radix Curcumae 10-60 Radix Angelicae Sinensis 10-50

Nature grass roots 5-40 DAKUGUA 20-160

Preferred weight (part) ratio range of preparation pharmaceutical formulation of the present invention is:

Agkistrodon snakeweed 8-50 Radix et Caulis Opuntiae Dillenii 20-45

Radix Ardisiae Punctatae grass 7-20 Fructus Trichosanthis 15-40

Semen Vaccariae 60-120 Radix Astragali 25-80

Pseudobulbus Cremastrae seu Pleiones 8-25 Radix Salviae Miltiorrhizae 12-50

Poria 20-50 Herba Scutellariae Barbatae 25-70

Radix Curcumae 12-55 Radix Angelicae Sinensis 15-40

Nature grass roots 7-30 DAKUGUA 25-120

The optimum weight of medicine of the present invention (part) proportioning is:

Agkistrodon snakeweed 20 Radix et Caulis Opuntiae Dilleniis 30

Radix Ardisiae Punctatae grass 12 Fructus Trichosanthis 30

Semen Vaccariae 90 Radixs Astragali 60

Pseudobulbus Cremastrae seu Pleiones 15 Radix Salviae Miltiorrhizae 30

Poria 30 Herba Scutellariae Barbataes 50

Radix Curcumae 20 Radix Angelicae Sinensis 20

Nature grass roots 20 DAKUGUA 90

The preparation method of medicine of the present invention is that the Chinese medicine method for making prepares routinely: the employing water alcohol method extracts, and above-mentioned each raw material arrangement is cleaned, and the decoction of heating, filtration, concentrated, ethanol extraction recovery concentrate, and make various dosage forms according to the different dosage form method for making then.

Dosage form of the present invention is meant said dosage form on any pharmaceutics, refers in particular to capsule, pill, tablet and oral liquid.

Clinical drug of the present invention uses the result to show to have following advantage:

1, to select natural plant for use be raw material in the present invention, and each component meets the pharmaceutical control law regulation.Utilize the comprehensive function treatment tumor disease of the Chinese medicine of respectively distinguishing the flavor of, nontoxic to human body.

2, after the present invention is prepared into various preparations, take more convenient, safety; Steady quality, determined curative effect.

3, crude drug of the present invention is originated and is easy to get, and has significantly reduced cost.

For showing medicine of the present invention, year 22 routine cases have been investigated continuously, wherein male 10 examples, women 12 examples, age 25-65 year from nineteen ninety to 2002 to the tumor treatment effect.And be contrast not take medicine of the present invention, select outpatient service and inpatient, the patient who takes this medicine 3-12 is followed the tracks of to investigate show that all tumors do not shift diffusion person before taking medicine, except that 1 people's death, all the other are still living and in good health per capita.

Instructions of taking: day clothes 5 grams, early half an hour ante cibum clothes down, best consumption is to defecate to be as the criterion for two, three times every day in the back of taking medicine, just time too much suitable decrement, very few suitably dosage; Take medicine at every turn and send down with guiding drug wine, wine is Chinese liquor; Taking medicine of the present invention every month was a course of treatment (about 150 grams).

Have no side effect behind the drug administration of the present invention, but the reaction that has the whole body to itch behind the individual patient clothes, edible Fructus Crataegi or haw products are separated it.

Relevant case patient's clinical efficacy is as mentioned below.

1, investigated 15 examples before 1997, wherein the some cases curative effect is as follows:

Liang Dongmei, woman, 31 years old.Suffered from thyroid carcinoma when studying in college in 1989.Behind Heilongjiang Province's forestry general bureau hospital surgical, sb.'s illness took a favorable turn, but mute.Recovery from illness after taking medicine three months.After graduating from university, appoint the public procurator, still working healthily so far.

Li Feng, man, 26 years old.Nineteen ninety is suffered from giant cell tumor of bone, in Heilongjiang Prov. Tumour Hospital's diagnosis of being in hospital, takes two courses of treatment of this medicine after leaving hospital, normal working, and 12 years are very stable always.Take off mourning clothes outside this medicine, do not carry out other treatment.

Year also cured the esophageal carcinoma of Jiang Fengyi from nineteen ninety-1997, Liu Chinese's hepatocarcinoma, the rectal cancer of Liu Chunlu.Wherein except that people's death, ten four-players are alive.

2, investigated 1 example in 1998.

Kan Shuzhen, woman, 58 years old, the auspicious shop accounting of Heilongjiang Province tobacco company.In May, 1997, discovery suffered from breast cancer, and performed the operation in province tumour hospital.Postoperative is arranged 45 days chemotherapy, and result to 30 day just can't stand.Condition of illness reflection is very strong: hair all takes off light, leukopenia, it is bad to sleep, no appetite, skeletonize, skin is the fish scale shape, general aching unbearably, the fingernail blackening.

In December, 1997 took this medicine in June, 1998, effect is very remarkable: appetite heightens, leukocyte is normal, and body weight increases to more than 120 jin by 90 jin, and sleep is normal, skin smooth as before, hair all grows, and from head to foot energetically, lives one the sky, the 7th buildings and does not also think tired several times, adhere to normal working, also help the shop assistant to shoulder smoke box sometimes.In May, 1998 employee's health check-up, tumor locus foci disappearance originally.

3, investigated 1 example in 1999

Liang Juan, woman, 26 years old.Be stained with peasant with forestry bureau.Find to suffer from the brain cancer in January, 1999.This month is the 3rd hospital surgical in the Heilongjiang Province.The postoperative binocular is blurring of vision still, in time takes this medicine three courses of treatment, feels fabulous, recently, to the check of three institutes, fully recovers.Be in hospital simultaneously with beam is beautiful, the Sun Dahu that performs an operation simultaneously, postoperative do not take this medicine, only do chemotherapy, in dead with the middle of the month.

4, investigated 5 examples in 2002

Xu Run, man, 60 years old.Suffered from carcinoma of penis before 20 years, operation is cut entirely.Suffer from rectal cancer February calendar year 2001, operation back health is difficult to control oneself.Begin to take this medicine April in this year, and all are normal now.

Li Juncai, man, 65 years old.Calendar year 2001 is diagnosed as gastric cancer late period through Heilongjiang Prov. Tumour Hospital.Require his speed operation, he is not bold enough to do.Health is weak, the feed difficulty.Begin to take this medicine from this year the beginning of the year, check that to August tumor disappears, he can run 5 kilometers every day.

Liu Yue, woman, 40 years old.Health check-up in April in this year finds that two breasts have tumor, begins to take this medicine May, and check gradually little July, checks that tumor all disappears October.

Mrs Su, 50 years old, suffered from nasopharyngeal carcinoma before 3 years, fail to respond to any medical treatment to national various big hospital after shifting diffusion, return burial in the grounds after death such as being stained with river forestry bureau, take this medicine after four courses of treatment, alive till now.

Lu Bingquan, man, 64 years old.Now live good wooden forward market, professor.October calendar year 2001, first hospital diagnosis was suffered from pulmonary carcinoma through Jiamusi.The back is checked to breathing out medical university, is come to the same thing.Took this medicine three months, physical recovery is normal.

The specific embodiment

Embodiment 1

Take by weighing raw material (kilogram) by following proportioning:

Agkistrodon snakeweed 50 Radix et Caulis Opuntiae Dilleniis 60

Radix Ardisiae Punctatae grass 20 Fructus Trichosanthis 60

Semen Vaccariae 150 Radixs Astragali 100

Pseudobulbus Cremastrae seu Pleiones 30 Radix Salviae Miltiorrhizae 60

Fu luxuriant growth 60 Herba Scutellariae Barbataes 80

Radix Curcumae 60 Radix Angelicae Sinensis 50

Nature grass roots 40 DAKUGUA 160

Method for making: above-mentioned raw materials is decocted with water secondary (1.5,1 hours), merge decoction liquor, use micro-pore-film filtration, aperture 0.8 μ m, filtered solution is concentrated into 400ml, add ethanol, making concentration of alcohol is 60% of concentrated solution, leaves standstill 48 hours, draw supernatant, reclaim ethanol and make medicinal liquid not have the ethanol flavor, be concentrated into 400ml, adding distil water adds sweet seasoning and stirs evenly to 1000ml, and embedding is in 10ml clothes liquid bottle, with 100 ℃ of 30 minutes flowing steam sterilizations, can make oral liquid.

Embodiment 2

Take by weighing raw material (kilogram) by following proportioning:

Agkistrodon snakeweed 10 Radix et Caulis Opuntiae Dilleniis 20

Radix Ardisiae Punctatae grass 5 Fructus Trichosanthis 10

Semen Vaccariae 50 Radixs Astragali 20

Pseudobulbus Cremastrae seu Pleiones 5 Radix Salviae Miltiorrhizae 10

Poria 15 Herba Scutellariae Barbataes 20

Radix Curcumae 10 Radix Angelicae Sinensis 10

Nature grass roots 50 DAKUGUA 20

Coating fluid prescription: acetyl O-phthalic acid cellulose 5 grams

Diethyl phthalate 10 grams

95% ethanol adds to 500ml

Mixing

Method for making: make concentrated solution by embodiment 1 method earlier and continue the wet piece of simmer down to, granulate with 60% concentration ethanol, drying, reuse 500 μ m sieve granulate, and the tablet machine tabletting places the coating container of 55cm to carry out spray coating in tablet.35 ℃ of tablet temperature maintenance in 50 ℃ of the gas flow temperatures, coating container.Coating finishes, 40 ℃ of dryings 10 minutes.Pill gets product.

Embodiment 3

Take by weighing raw material (kilogram) by following proportioning:

Agkistrodon snakeweed 25 Radix et Caulis Opuntiae Dilleniis 35

Radix Ardisiae Punctatae grass 15 Fructus Trichosanthis 40

Semen Vaccariae 85 Radixs Astragali 70

Pseudobulbus Cremastrae seu Pleiones 10 Radix Salviae Miltiorrhizae 28

Poria 35 Herba Scutellariae Barbataes 45

Radix Curcumae 30 Radix Angelicae Sinensis 30

Nature grass roots 20 DAKUGUA 85

Method for making: make concentrated solution by embodiment 1 method earlier, continue the wet piece of simmer down to, granulate with 60% concentration ethanol, drying, reuse 200 μ m sieve granulate, and selecting cellulose acetate-phthalate (CAP) for use is the capsule material, makes capsule.

Embodiment 4

Press embodiment 3 proportioning raw materials.

Method for making: make concentrated solution by embodiment 1 method earlier, continue the wet piece of simmer down to, granulate with 60% concentration ethanol, drying, reuse 200 μ m sieve granulate.With granule and 2 magnesium stearate mix homogeneously, the tablet machine tabletting can make tablet.

Claims (5)

1, a kind of medicine for the treatment of tumor disease, it is the medicament of being made by the following weight parts proportion raw material:

Agkistrodon snakeweed 10-50 Radix et Caulis Opuntiae Dillenii 20-60

Radix Ardisiae Punctatae grass 5-20 Fructus Trichosanthis 10-60

Semen Vaccariae 50-150 Radix Astragali 20-100

Pseudobulbus Cremastrae seu Pleiones 5-30 Radix Salviae Miltiorrhizae 10-60

Poria 15-60 Herba Scutellariae Barbatae 20-80

Radix Curcumae 10-60 Radix Angelicae Sinensis 10-50

Nature grass roots 5-40 DAKUGUA 20-160.

2, the medicine of treatment tumor disease according to claim 1, it is the medicament of being made by the following weight parts proportion raw material:

Agkistrodon snakeweed 8-50 Radix et Caulis Opuntiae Dillenii 20-45

Radix Ardisiae Punctatae grass 7-20 Fructus Trichosanthis 15-40

Semen Vaccariae 60-120 Radix Astragali 25-80

Pseudobulbus Cremastrae seu Pleiones 8-25 Radix Salviae Miltiorrhizae 12-50

Poria 20-50 Herba Scutellariae Barbatae 25-70

Radix Curcumae 12-55 Radix Angelicae Sinensis 15-40

Nature grass roots 7-30 DAKUGUA 25-120.

3, the medicine of treatment tumor disease according to claim 1, it is the medicament of being made by the following weight parts proportion raw material:

Agkistrodon snakeweed 20 Radix et Caulis Opuntiae Dilleniis 30

Radix Ardisiae Punctatae grass 12 Fructus Trichosanthis 30

Semen Vaccariae 90 Radixs Astragali 60

Pseudobulbus Cremastrae seu Pleiones 15 Radix Salviae Miltiorrhizae 30

Poria 30 Herba Scutellariae Barbataes 50

Radix Curcumae 20 Radix Angelicae Sinensis 20

Nature grass roots 20 DAKUGUA 90.

4, according to the medicine of claim 1,2 or 3 described treatment tumor diseases, described medicament is a said dosage form on any pharmaceutics.

5, the medicine of treatment tumor disease according to claim 4, described medicament are capsule, pill, tablet or oral liquid.