CN1739734A - Chinese medicine prepn for treating stomatitis and its prepn process - Google Patents
Chinese medicine prepn for treating stomatitis and its prepn process Download PDFInfo
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Abstract
The Chinese medicine preparation for treating stomatitis is prepared with asparagus root, ophiopogon root, figwort, licorice and honeysuckle. It preparation process is also disclosed.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation for the treatment of oral inflammation and preparation method thereof.
Background technology
Oral inflammation is a kind of oral cavity commonly encountered diseases, mainly show as and produce stomatocace or herpes, can produce a plurality of ulcer or herpes when serious, except that producing pain, also have symptoms such as heating, xerostomia, thirsty, five vexed hot-tempered, insomnias, night sweat, tongue pulse condition and occur, influence the healthy of people and take food.
The traditional Chinese medical science thinks that hyperactivity of fire caused by deficiency of YIN is the paathogenic factor of oral inflammation.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of oral inflammation, be used for the treatment of oral inflammation.
Technical scheme of the present invention is: a kind of Chinese medicine preparation for the treatment of oral inflammation is the medicament of being made by following materials based on weight:
1 part～98 parts of Radix Asparagis, 1 part～98 parts of Radix Ophiopogonis, 1 part～98 parts of Radix Scrophulariaes, 1 part～80 parts in Radix Glycyrrhizae, 1 part～100 parts of Flos Loniceraes.
The Chinese medicine preparation of described treatment oral inflammation, the preferred parts by weight of each raw material are:
5 parts～50 parts of Radix Asparagis, 5 parts～50 parts of Radix Ophiopogonis, 5 parts～50 parts of Radix Scrophulariaes, 2 parts～40 parts in Radix Glycyrrhizae, 5 parts～80 parts of Flos Loniceraes.
In the Chinese medicine preparation of described treatment oral inflammation, the optimum weight umber of each raw material is: 25 parts of Radix Asparagis, 25 parts of Radix Ophiopogonis, 25 parts of Radix Scrophulariaes, 12.5 parts in Radix Glycyrrhizae, 30 parts of Flos Loniceraes.
The Chinese medicine preparation of described treatment oral inflammation can be for there being the dosage form on sugared granule, sugar free granule, tablet, capsule, powder and other pharmaceutics.
The Chinese medicine preparation of above-mentioned treatment oral inflammation can adopt following method preparation:
(1) takes by weighing five tastes medicinal raw material by above-mentioned prescription; (2) above-mentioned raw materials is dropped into steaming and decocting and extract in the pot, add water logging and cross medical material, open vapour cooking twice, filter merging filtrate; (3) to be concentrated into relative density be 1.09～1.12 (60 ℃ of mensuration) for liquid filter, is cooled to room temperature, adds ethanol, stirs, and leaves standstill more than 12 hours and make precipitation, gets supernatant, reclaims ethanol, and being concentrated into relative density is the extractum of 1.30～1.33 (60 ℃ of mensuration); (4) add adjuvant, make corresponding dosage form by the preparation technology of required dosage form.
According to different dosage forms, also can adopt traditional extracting method beyond the said method to extract and prepare.
Described adjuvant can be in the various auxiliary agents such as binding agent, filler, correctives, wetting agent one or more.
Instructions of taking is: one day 1-2 time, each medicament of taking in is equivalent to primary crude drug 11.8g, and the child reduces by half.
Flos Lonicerae heat clearing away, detoxifcation, antibiotic; Radix Asparagi YIN nourishing, heat clearing away, promote the production of body fluid, pathogenic fire reducing; Radix Ophiopogonis nourishing YIN and moistening the lung, the cough-relieving of promoting the production of body fluid, relieving restlessness clears away heart-fire; Radix Scrophulariae removing heat from blood YIN nourishing, let out scorching detoxifcation; Radix Glycyrrhizae has heat-clearing and toxic substances removing, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.The Chinese medicine preparation of treatment oral inflammation of the present invention, all medicines are collaborative, have nourishing YIN and clearing away heat, and the effect of removing toxic substances and promoting subsidence of swelling is used for the oral inflammation due to the hyperactivity of fire caused by deficiency of YIN, has the good characteristics of therapeutic effect.
For the effect of further objective evaluation Chinese medicine preparation of the present invention, carried out clinical trial, finish 362 routine clinical trials altogether by Nanfang Hospital of No.1 Military Medical Univ., Affiliated Hospital of Medical Colleges Of Guilin, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Med.
Following condition is satisfied in test: (1) meets recurrent aphtha or two sick kinds of herpetic aphtha in the Western medicine diagnose stomatitis; (2) meet differential diagnosis in tcm aphtha card and belong to type of hyperactivity of fire caused by deficiency of YIN; (3) age is between 18～65 years old; (4) course of disease is in 5 days.
Medication: institute's with medicament Chinese medicine granules of the present invention, every day 2 times, each 20g (2 bags).The matched group ZHIBAI DIHUANG WAN, each 6 grams, every day 3 times, 7 days courses of treatment.
Curative effect observation project: (1) oral inflammation symptom is mainly observed number, size, herpes scope and pain degree, body temperature, gingival hemorrhage, the submandibular lymph nodes of oral ulcer.(2) the differential diagnosis in tcm symptom is mainly observed heating, xerostomia, thirsty, five vexed hot-tempered, insomnias, robber, tongue pulse condition.Above-mentioned two when going to a doctor, the treatment back observed or estimated in the 3rd day and the 7th day.
Efficacy assessment standard: (1) clinical recovery stomatocace or herpes disappear, other transference cure.(2) produce effects stomatocace or herpes are clearly better (have 2 in pain, area or scope, the quantity and reduce by 2 grades), and other symptoms take a turn for the better.(3) effectively stomatocace or herpes take a turn for the better (have 2 in pain, area or scope, the quantity and reduce by 2 grades), and other symptoms take a turn for the better.(4) invalid each symptom and sign does not all have improvement or increases the weight of.
Case situation: observe qualified experimenter's 362 examples altogether, recurrent aphtha person 255 examples wherein, herpetic stomatitis person 107 examples; Age 18-29 year person's 122 examples, 30-39 year person's 125 examples, 40-49 year person's 58 examples, 50-65 year person's 57 examples; Male patient's 154 examples, female patient 208 examples, course of disease 1-3 days person's 254 examples, 4-5 days person's 108 examples.Its total effects sees Table 1, and ulcer or herpes improvement degree see Table 2, clinical symptoms and sign disappearance rate or normalization rate see Table 3
As can be seen from Table 1, the Chinese medicine preparation of treatment stomatitis of the present invention, cure rate, the obvious effective rate of treatment recurrent aphtha are 65.1%, total effective rate is 86.98%; Recovery from illness, the obvious effective rate of treatment herpetic stomatitis are 57.5%, and total effective rate is 86.21%, and the total effective rate of treatment oral inflammation is 86.75%.And the recovery from illness of treatment of control group recurrent aphtha, obvious effective rate are 60%, and total effective rate is 82.50%; Recovery from illness, the obvious effective rate of treatment herpetic stomatitis are 50%, and total effective rate is 75%, and the total effective rate of treatment oral inflammation is 80%.The effect that shows Chinese medicine preparation treatment oral inflammation of the present invention is better than matched group.
Table 1 clinical trial total effects synopsis
| Group | The example number | Recovery from illness | Produce effects | Effectively | Invalid | Total effective rate (%) | P |
| Recurrent aphtha | The treatment group | 215 | 95 | 45 | 47 | 28 | 86.98 | |
| Matched group | 40 | 17 | 7 | 9 | 7 | 82.50 | P＞0.05 | |
| Herpetic stomatitis | The treatment group | 87 | 35 | 15 | 25 | 12 | 86.21 | |
| Matched group | 20 | 6 | 4 | 5 | 5 | 75.00 | P＞0.05 | |
| Add up to | The treatment group | 302 | 130 | 60 | 72 | 40 | 86.75 | |
| Matched group | 60 | 23 | 11 | 14 | 12 | 80.00 | P＞0.05 |
As can be seen from Table 2, the Chinese medicine preparation of treatment stomatitis of the present invention can significantly alleviate the pain due to ulcer or the herpes, and the improvement rate is respectively 87.4%, 85.1%, and matched group improvement rate is respectively 85%, 80%; The curative effect that the treatment group alleviates the pain due to the herpes is better than matched group.Minimizing curative effect to ulcer size and skin ulcer rash scope is preferable, and the improvement rate is respectively 81.4%, 74.7%, and matched group is respectively 72.5%, 65%, is better than matched group equally.
Table 2 ulcer or skin ulcer rash are improved degree
| Group | The example number | Increase the weight of | Do not have and improve | Improve 1 grade | Improve 2 grades | Improve 3 grades | Improvement rate (%) | |
| The ulcer decreased number | The treatment group Δ | 215 | 3 | 58 | 87 | 55 | 12 | 71.6 |
| Matched group | 40 | 1 | 9 | 21 | 7 | 2 | 75.0 | |
| The ulcer size reduces | The treatment group Δ | 215 | 2 | 38 | 95 | 45 | 35 | 81.4 |
| Matched group | 40 | 1 | 10 | 15 | 9 | 5 | 72.5 | |
| Ulcer pain is improved | The treatment group Δ | 215 | 2 | 25 | 60 | 78 | 50 | 87.4 |
| Matched group | 40 | 0 | 6 | 10 | 18 | 6 | 85.0 | |
| The herpes scope reduces | The treatment group Δ | 87 | 5 | 17 | 28 | 20 | 17 | 74.7 |
| Matched group | 20 | 2 | 5 | 5 | 3 | 5 | 65.0 | |
| Herpes pain is improved | The treatment group * | 87 | 2 | 11 | 27 | 25 | 22 | 85.1 |
| Matched group | 20 | 0 | 4 | 9 | 4 | 3 | 80.0 |
Δ P＞00.05,
*P＜0.05 treatment group and matched group are relatively.
Improve 1 grade of expression: treatment back severity extent reduces by 1 grade before the treatment
Improve 2 grades of expressions: treatment back severity extent reduces by 2 grades before the treatment
Improve 3 grades of expressions: treatment back severity extent reduces by 3 grades before the treatment
As can be seen from Table 3, Chinese medicine preparation of the present invention not only all has improvement in various degree to herpes scope, the pain degree of ulcer number, size and the herpetic stomatitis of recurrent aphtha, and contrast before and after other related symptoms treatment due to the hyperactivity of fire caused by deficiency of YIN is also had curative effect preferably.
The improvement situation contrast table of table 3 pair each disease
| Group | Original routine number before the treatment | The routine number of treatment back disappearance | Disappearance rate or normalization rate % | |
| The ulcer number | The treatment group | 215 | 125 | 58.1 |
| Matched group | 40 | 21 | 52.5 | |
| The ulcer size | The treatment group | 215 | 126 | 58.6 |
| Matched group | 40 | 21 | 52.5 | |
| Ulcer pain | The treatment group | 215 | 135 | 62.8 |
| Matched group | 40 | 26 | 65 | |
| The herpes scope | The treatment group | 87 | 47 | 54 |
| Matched group | 20 | 9 | 45 | |
| Herpes pain | The treatment group | 87 | 58 | 66.7 |
| Matched group | 20 | 13 | 75 | |
| Xerostomia | The treatment group | 205 | 152 | 74.2 |
| Matched group | 32 | 27 | 84.4 | |
| Thirsty | The treatment group | 172 | 138 | 80.2 |
| Matched group | 30 | 25 | 83.3 | |
| Dryness of the tongue | The treatment group | 140 | 123 | 87.9 |
| Matched group | 25 | 16 | 64.0 | |
| Five is vexed hot-tempered | The treatment group | 98 | 73 | 74.5 |
| Matched group | 28 | 17 | 60.7 | |
| Insomnia | The treatment group | 94 | 64 | 68.1 |
| Matched group | 23 | 11 | 47.8 | |
| Night sweat | The treatment group | 86 | 70 | 81.4 |
| Matched group | 20 | 14 | 70 | |
| Heating | The treatment group | 33 | 30 | 90.1 |
| Matched group | 5 | 4 | 80 | |
| The feed difficulty | The treatment group | 112 | 103 | 91.9 |
| Matched group | 12 | 10 | 83.3 | |
| The submandibular lymph nodes enlargement | The treatment group | 52 | 42 | 80.8 |
| Matched group | 9 | 7 | 77.8 |
Carry out the safety testing result simultaneously and show that Chinese medicine preparation safety of the present invention is good, finds no toxic and side effects.
In sum, pharmaceutical preparation of the present invention is used for the treatment of that oral inflammation can obviously improve patient's main clinic symptoms, sign due to the hyperactivity of fire caused by deficiency of YIN, is used for recurrent aphtha, herpetic stomatitis.Do not find in the therapeutic process that it is to darling renal function and blood system infringement, clinical practice safety.
For pharmaceutical preparation of the present invention, also carried out pharmaceutical research, respectively antiinflammatory action, external bacteriostasis, strengthening the body resistance effect are promoted the production of body fluid to moisturize to act on and test, estimate as follows:
(1) antiinflammatory action
1, to the bullate influence of rat granuloma
70 of SD male rats, 120-180g is divided into 7 groups at random by body weight: the solvent control group; Positive drug control group comprises dexamethasone 0.96mg/kg group, Waterelon Frost Lozenges 0.5,1.0k/kg group; The runny plaste 1.0,2.0 that Chinese medicine composition of the present invention extracts, 4.0g/kg group.10 of every group of rats, gastric infusion 1.0ml/100g.Make abdominal incision under ether light anaesthesia aseptic condition, it is subcutaneous that two sterilization cotton balls (each cotton balls weighs 50 ± 1mg, autoclaving, each adds ampicillin 1mg/0.1ml/, 50 ℃ of stove-dryings) are implanted rat both sides groin respectively.Performing the operation began administration the same day, and continuous 7 days, rat was put to death in cervical vertebra dislocation in the 8th day, takes out cotton balls, weighs after 1 hour in 90 ℃ of baking oven inner dryings, deducts the raw cotton ball weight, is the granuloma net weight, the results are shown in Table 4.
Table 4 Chinese medicine preparation of the present invention is to the bullate influence of rat granuloma (X ± SD)
| Group | Dosage (g/kg) | Number of animals (only) | Granuloma induced by implantation of cotton pellets (mg/100g) |
| The solvent control group | Equal-volume | 10 | 37.66±7.21 |
| Dexamethasone | 0.00096 | 10 | 22.53±3.06 *** |
| Waterelon Frost Lozenges | 0.5 | 10 | 32.72±7.60 * |
| 1.0 | 10 | 29.55±6.56 ** | |
| Chinese medicine runny plaste of the present invention | 1.0 | 10 | 27.71±6.27 ** |
| 2.0 | 10 | 26.03±4.96 *** | |
| 4.0 | 10 | 23.81±5.55 *** |
Compare with the solvent control group
*P＞0.05,
*P＜0.05,
* *P＜0.01.
As can be seen from Table 4, the extractum of pharmaceutical composition of the present invention can obviously suppress the hypertrophy of chronic granuloma, and has dose-effect relationship.
2, on Carrageenan causes the influence of rat footpad swelling
70 of male SD rats, 120-150g is divided into 7 groups at random by body weight: the solvent control group; Positive drug control group comprises aspirin 60mg/kg group, Waterelon Frost Lozenges 0.5,1.0k/kg group; Chinese medicine runny plaste 1.0,2.0 of the present invention, 4.0g/kg group.10 of every group of rats, gastric infusion.Use the blood capillary drainage, measure and respectively organize the right back sufficient volume of rat, only in the right back sufficient lift of rat, injected 1% carrageenin solution 0.1ml/ in preceding 0.5 hour, measured once right back sufficient volume, observe its swelling degree every 1 hour in administration.The result shows that injection can make the right back foot swelling of rat in the carrageenin foot lift, and swelling in 3 hours reaches the peak, and 6 little fashion do not recover normal.Irritate stomach in advance and give aspirin, Waterelon Frost Lozenges, Chinese medical concrete of the present invention, all can obviously alleviate the foot swelling degree, action intensity is relevant with dosage, and effect was kept more than 4 hours.
3, to the influence of mouse peritoneum capillary permeability
70 of NH mices, 18-22g, male and female half and half are divided into 7 groups at random by sex and body weight: the solvent control group; Positive drug control group comprises aspirin 100mg/kg group, Waterelon Frost Lozenges 0.5,1.0k/kg group, Chinese medicine runny plaste 2.0,4.0 of the present invention, 8.0g/kg group.10 of every group of mices, gastric infusion.After the administration 1 hour, mice is tail vein injection 1% Yi Wensilan 0.05ml/10g respectively, pneumoretroperitoneum was injected 0.7% acetum 0.1ml/10g in 5 minutes, in injecting back 20 minutes with the mice sacrificed by exsanguination, used the normal saline flushing abdominal cavity, collect cleanout fluid, and be diluted to 10ml, and add 0.1ml0.1NnaOH then, placed after 1 hour 1000gxg centrifugal 10 minutes, get supernatant in 510nm place colorimetric, the results are shown in Table 5.
The influence of table 5 pair mouse peritoneum capillary permeability (X ± SD)
| Group | Dosage (g/kg) | Number of animals (only) | Optical density (D) |
| Solvent control | Equal-volume | 10 | 0.253±0.093 |
| Aspirin | 0.1 | 10 | 0.100±0.036 *** |
| Waterelon Frost Lozenges | 0.5 | 10 | 0.179±0.061 ** |
| 1.0 | 10 | 0.133±0.042 *** | |
| Chinese medicine runny plaste of the present invention | 2.0 | 10 | 0.166±0.038 ** |
| 4.0 | 10 | 0.144±0.022 *** | |
| 8.0 | 10 | 0.107±0.039 *** |
Compare with the solvent control group
*P＞0.05,
*P＜0.05,
* *P＜0.01.
As can be seen from Table 5, Chinese medicine 2.0,4.0 of the present invention, 8.0g/kg all can suppress the mouse peritoneum capillary permeability that acetic acid causes and increase, and drug potency is relevant with dosage.
(2) external bacteriostasis
In aseptic plate, add 2% broth agar culture medium 20ml/ ware (Diplococcus pneumoniae, the Hemolytic streptococcus first, the second blood agar culture-medium), after treating that it solidifies, the test organisms liquid that to cultivate 18 hours (comprises golden Fructus Vitis viniferae 10 strains (wherein sensitive organism 5 strains, fastbacteria 5 strains), Diplococcus pneumoniae 10 strains, the Hemolytic streptococcus first, each 10 strain of second), be uniformly coated on planar surface with aseptic cotton rod, use metal piercing device (diameter 1.0cm) in plate, evenly to bore a hole several then, it is rebasing to add 0.1ml2% steamed beef soup agar at the bottom of the hole, after solidifying, add cefradine 30.0 μ g/ holes respectively, Chinese medicine runny plaste 70 of the present invention, 60,50,40,30,20, the 10mg/ hole, put in 37 ℃ of ovum casees and cultivated 18 hours, the record antibacterial circle diameter.The results are shown in Table 6
The effect of table 6 pair various pathogenic bacterium
| Group | Liquor strength (mg/ml) | Antibacterial circle diameter (mm) | ||||
| Gold Fructus Vitis viniferae (persister) | Gold Fructus Vitis viniferae (sensitive strain) | Lung is two | The first chain | The second chain | ||
| Chinese medicine of the present invention | 10 | 16.0 | 17.5 | --- | --- | --- |
| 20 | 16.8 | 20.5 | --- | --- | --- | |
| 30 | 20.5 | 26.0 | --- | 14.0 | --- | |
| 40 | 24.0 | 28.0 | --- | 15.0 | --- | |
| 50 | 27.2 | 30.5 | 15.0 | 16.0 | 15.0 | |
| 60 | 29.2 | 32.0 | 18.0 | 18.5 | 18.0 | |
| 70 | 31.5 | 34.0 | 20.0 | 21.0 | 19.5 | |
| The cefradine capsule | 0.03 | 32.0 | 35.0 | 29.0 | 28.0 | 27.0 |
Result of the test shows, the Chinese medicine of treatment oral inflammation of the present invention all has inhibitory action to the growth of golden Fructus Vitis viniferae (sensitive strain and persister), Diplococcus pneumoniae, Hemolytic streptococcus first, second when finite concentration, especially obvious to golden Fructus Vitis viniferae inhibitory action.
(3) strengthening the body resistance effect
70 of NH mices, 24-26g, male and female half and half are divided into 7 groups at random by sex and body weight: the solvent control group; Positive controls comprises aspirin 5.0mg/kg group, Waterelon Frost Lozenges 0.5g/kg, 1.0g/kg group, Chinese medicine runny plaste 2.0,4.0 of the present invention, 8.0g/kg group.10 of every group of mices, with 1.25%2,4-dinitrochlorobenzene acetone solution gives the mouse back subcutaneous injection with sensitization, every 0.02ml.Sensitization one day after, the beginning gastric infusion, continuous 9 days, 4-dinitrochlorobenzene acetone solution was annotated under the right sufficient lift of mice, every 0.02ml with 0.25%2 in the 10th day, acetone solution to parapodum injection same volume compares, cutting two foots from ankle after 38 hours, weigh on balance, is the swelling degree with the weight difference of two foots.The results are shown in Table 7
Table 7 pairs 2, and the influence of 4-dinitrochlorobenzene induced mice delayed hypersensitivity (X ± SD)
| Group | Dosage (g/kg) | Number of animals (only) | Swelling value (mg/ only) | Suppression ratio (%) |
| Solvent control | Equal-volume | 10 | 42.71±22.24 | |
| Aspirin | 0.1 | 10 | 11.17±7.44 *** | 73.58 |
| Waterelon Frost Lozenges | 0.5 | 10 | 16.99±9.27 *** | 60.22 |
| 1.0 | 10 | 11.35±7.80 *** | 73.42 | |
| Chinese medicine of the present invention | 2.0 | 10 | 18.25±8.01 *** | 57.27 |
| 4.0 | 10 | 13.57±6.28 *** | 68.22 | |
| 8.0 | 10 | 9.58±4.97 *** | 77.57 |
Annotate: compare with the solvent control group
*P＞0.05,
*P＜0.05,
* *P＜0.01
By the result as can be known, Chinese medicine of the present invention can suppress 2, the right back foot swelling of mice due to the 4-dinitrochlorobenzene, and have dose-effect relationship, act on similar to Waterelon Frost Lozenges, with the solvent control group relatively P value equal＜0.01.
(4) effect of moisturizing of promoting the production of body fluid
60 of NH mices, 18-22g, male and female half and half are divided into 7 groups at random by sex and body weight: the solvent control group; Ammonia chloride 0.5, the 1.0g/kg group; Chinese medicine runny plaste 2.0,4.0 of the present invention, 8.0g/kg group.10 of every group of mices, half an hour behind the gastric infusion, lumbar injection 0.5% phenol red solution 0.5ml/ only injects back cervical vertebra half an hour dislocation and puts to death mice, peels off the trachea surrounding tissue, cut one section trachea down to the trachea bifurcation from thyroid cartilage, put into the test tube that fills the 2ml normal saline, add 2 sodium hydroxide again, with 721 type spectrophotometers, mensuration is respectively organized optical density in wavelength 546nm place, checks in phenol red content (μ g/ml) on phenol red normal line.The results are shown in Table 8
Table 8 Chinese medicine of the present invention is to the influence of the phenol red excretion amount of mice trachea section (X ± SD)
| Group | Dosage (g/kg) | Number of animals (only) | Phenol red output (μ g/ml) | Increase percentage rate (%) |
| Solvent control | Equal-volume | 10 | 0.39±0.14 | |
| Ammonia chloride | 0.5 | 10 | 0.44±0.19 * | 12.82 |
| 1.0 | 10 | 0.64±0.11 *** | 64.10 | |
| Chinese medicine of the present invention | 2.0 | 10 | 0.42±0.28 * | 7.69 |
| 4.0 | 10 | 0.52±0.15 * | 33.33 | |
| 8.0 | 10 | 0.58±0.15 *** | 48.72 |
Annotate: compare with the solvent control group
*P＞0.05,
*P＜0.05,
* *P＜0.01
By test result as can be seen, Chinese medicine of the present invention has certain facilitation to mouse breathing road secretory function, and has dose-effect relationship.
The specific embodiment
Below in conjunction with specific embodiment KOUYANQING preparation of the present invention is described further.
Embodiment 1
Present embodiment is for there being sugared granule, and the consumption of each raw material is: Radix Asparagi 25kg, Radix Ophiopogonis 25kg, Radix Scrophulariae 25kg, Radix Glycyrrhizae 12.5kg, Flos Lonicerae 30kg.
Adopt following method preparation:
(1) takes by weighing five tastes medicinal raw material by above-mentioned prescription; (2) above-mentioned raw materials is dropped into steaming and decocting and extract in the pot, add water logging and cross medical material, open vapour cooking twice, filter merging filtrate; (3) to be concentrated into relative density be 1.09～1.12 (60 ℃ of mensuration) for liquid filter, is cooled to room temperature, adds ethanol, stir, leave standstill more than 12 hours and make precipitation, get supernatant, reclaim ethanol, being concentrated into relative density is the extractum (moisture 35%) of 1.30～1.33 (60 ℃ of mensuration); (4) add adjuvants such as powdered sugar, starch slurry and binding agent, wetting agent and make soft material, supplementary product consumption is 9 times of used extractum weight, again through granulation, dry, the granulate branch bag of packing into becomes granule, every packed medicine 10g (being equivalent to primary crude drug 5.9g).
Instructions of taking: every day 1-2 time, each 20 grams (two bags).
Embodiment 2
Present embodiment is a sugar free granule, and the consumption of each raw material is: Radix Asparagi 25kg, Radix Ophiopogonis 25kg, Radix Scrophulariae 25kg, Radix Glycyrrhizae 12.5kg, Flos Lonicerae 30kg.
Extract by method among the embodiment 1 and to add dextrin or dextrin and sweeting agent behind the extractum, again through granulation, dry, the granulate branch bag of packing into becomes granule, every packed medicine 3g (being equivalent to primary crude drug 5.9g).
Instructions of taking is: every day 1-2 time, each 2 bags.
Embodiment 3
Present embodiment is a tablet, and the consumption of each raw material is: Radix Asparagi 25kg, Radix Ophiopogonis 25kg, Radix Scrophulariae 25kg, Radix Glycyrrhizae 12.5kg, Flos Lonicerae 30kg.
Extract the extractum after drying by method among the embodiment 1, pulverize, make granule, drying, compacting is in blocks, and every is equivalent to primary crude drug 2.95g, promptly.
Instructions of taking is: every day 1-2 time, each 4.
Embodiment 4
Present embodiment is a capsule, and the consumption of each raw material is: Radix Asparagi 25kg, Radix Ophiopogonis 25kg, Radix Scrophulariae 25kg, Radix Glycyrrhizae 12.5kg, Flos Lonicerae 30kg.
Extract the extractum after drying by method among the embodiment 1, pulverize, incapsulate, every powder charge is equivalent to primary crude drug 5.9g, promptly.
Instructions of taking is: every day 1-2 time, each 2.
Embodiment 5
Present embodiment is an oral liquid, and the consumption of each raw material is: Radix Asparagi 25kg, Radix Ophiopogonis 25kg, Radix Scrophulariae 25kg, Radix Glycyrrhizae 12.5kg, Flos Lonicerae 30kg.
Add simple syrup by method among the embodiment 1 after extracting extractum, it is an amount of to add water, stirs evenly, filter, and embedding, every bottle of 10ml (being equivalent to primary crude drug 5.9g) sterilization, promptly.
Instructions of taking is: every day 1-2 time, each 2 bottles.
Embodiment 6
Present embodiment is a sugar free granule, and the consumption of each raw material is: Radix Asparagi 1kg, Radix Ophiopogonis 98kg, Radix Scrophulariae 1kg, Radix Glycyrrhizae 80kg, Flos Lonicerae 1kg.
Extract by method among the embodiment 1 and to add dextrin or dextrin and sweeting agent behind the extractum, again through granulation, dry, the granulate branch bag of packing into becomes granule, every bag of 3g is equivalent to primary crude drug 5.9g.
Instructions of taking is: every day 1-2 time, each 2 bags.
Embodiment 7
Present embodiment is a sugar free granule, and the consumption of each raw material is: Radix Asparagi 98kg, Radix Ophiopogonis 1kg, Radix Scrophulariae 98kg, Radix Glycyrrhizae 1kg, Flos Lonicerae 100kg.
Extract by method among the embodiment 1 and to add dextrin or dextrin and sweeting agent behind the extractum, again through granulation, dry, the granulate branch bag of packing into becomes granule, every packed medicine is equivalent to primary crude drug 5.9g.
Instructions of taking is: every day 1-2 time, each 2 bags.
Embodiment 8
Present embodiment is a tablet, and the consumption of each raw material is: Radix Asparagi 5kg, Radix Ophiopogonis 50kg, Radix Scrophulariae 5kg, Radix Glycyrrhizae 40kg, Flos Lonicerae 5kg.
Extract the extractum after drying by method among the embodiment 1, pulverize, make granule, drying, compacting is in blocks, and every is equivalent to primary crude drug 2.95g, promptly.
Instructions of taking is: every day 1-2 time, each 4.
Embodiment 9
Present embodiment is a capsule, and the consumption of each raw material is: Radix Asparagi 50kg, Radix Ophiopogonis 5kg, Radix Scrophulariae 50kg, Radix Glycyrrhizae 2kg, Flos Lonicerae 80kg.
Extract the extractum after drying by method among the embodiment 1, pulverize, incapsulate, every powder charge is equivalent to primary crude drug 5.9g, promptly.
Instructions of taking is: every day 1-2 time, each 2.
Embodiment 10
Present embodiment is an oral liquid, and the consumption of each raw material is: Radix Asparagi 10kg, Radix Ophiopogonis 60kg, Radix Scrophulariae 45kg, Radix Glycyrrhizae 30kg, Flos Lonicerae 30kg.
Add simple syrup by method among the embodiment 1 after extracting extractum, it is an amount of to add water, stirs evenly, filter, and embedding, every bottle of 10ml (being equivalent to primary crude drug 5.9g) sterilization, promptly.
Instructions of taking is: every day 1-2 time, each 2 bottles.
Embodiment 11
Present embodiment is a sugar free granule, and the consumption of each raw material is: Radix Asparagi 60kg, Radix Ophiopogonis 60kg, Radix Scrophulariae 41kg, Radix Glycyrrhizae 30kg, Flos Lonicerae 50kg.
Extract by method among the embodiment 1 and to add dextrin or dextrin and sweeting agent behind the extractum, again through granulation, dry, the granulate branch bag of packing into becomes granule, every bag of 3g is equivalent to primary crude drug 5.9g.
Instructions of taking is: every day 1-2 time, each 2 bags.
Claims (5)
1, a kind of Chinese medicine preparation for the treatment of oral inflammation is the medicament of being made by following materials based on weight:
1 part～98 parts of Radix Asparagis, 1 part～98 parts of Radix Ophiopogonis, 1 part～98 parts of Radix Scrophulariaes, 1 part～80 parts in Radix Glycyrrhizae, 1 part～100 parts of Flos Loniceraes.
2, the Chinese medicine preparation of treatment oral inflammation as claimed in claim 1 is characterized in that: each raw material weight umber is in the described Chinese medicine preparation:
5 parts～50 parts of Radix Asparagis, 5 parts～50 parts of Radix Ophiopogonis, 5 parts～50 parts of Radix Scrophulariaes, 2 parts～40 parts in Radix Glycyrrhizae, 5 parts～80 parts of Flos Loniceraes.
3, the Chinese medicine preparation of treatment oral inflammation as claimed in claim 1 is characterized in that: each raw materials in part by weight is in the Chinese medicine preparation of described treatment oral inflammation: 25 parts of Radix Asparagis, 25 parts of Radix Ophiopogonis, 25 parts of Radix Scrophulariaes, 12.5 parts in Radix Glycyrrhizae, 30 parts of Flos Loniceraes.
4, as the Chinese medicine preparation of described treatment oral inflammation one of in the claim 1 to 3, it is characterized in that: described Chinese medicine preparation is the dosage form that has on sugared granule, sugar free granule type, tablet, capsule, powder, unguentum, oral liquid, syrup, electuary, mixture, buccal tablet, effervescent tablet and other pharmaceutics.
5, the preparation method of the Chinese medicine preparation of the described treatment oral inflammation of a kind of claim 1 is characterized in that this method comprises following process:
(1) takes by weighing five tastes medicinal raw material by above-mentioned prescription; (2) above-mentioned raw materials is dropped into steaming and decocting and extract in the pot, add water logging and cross medical material, open vapour cooking twice, filter merging filtrate; Relative density was 1.09～1.12 when (3) the liquid filter was concentrated into 60 ℃, was cooled to room temperature, added ethanol, stirred, and left standstill more than 12 hours and made precipitation, got supernatant, reclaimed ethanol, and relative density is 1.30～1.33 extractum when being concentrated into 60 ℃; (4) add adjuvant, make corresponding dosage form by the preparation technology of required dosage form.
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| CNB2005100985894A CN100372561C (en) | 2005-09-06 | 2005-09-06 | Chinese medicine prepn for treating stomatitis and its prepn process |
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| CNB2005100985894A CN100372561C (en) | 2005-09-06 | 2005-09-06 | Chinese medicine prepn for treating stomatitis and its prepn process |
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| CN101732561A (en) * | 2009-12-29 | 2010-06-16 | 重庆精鼎药材科技开发有限公司 | Health-care medicine used for preventing and treating chronic pharyngitis and preparation method thereof |
| CN101129774B (en) * | 2007-09-21 | 2010-07-14 | 广州白云山和记黄埔中药有限公司 | Traditional Chinese medicine preparation for treating inflammation of oral cavity and method of producing the same |
| CN101491634B (en) * | 2008-01-23 | 2011-08-17 | 北京亚东生物制药有限公司 | Traditional Chinese medicine composition for treating chronic pharyngitis and preparation method and quality control method thereof |
| CN102225150A (en) * | 2011-06-15 | 2011-10-26 | 广州白云山和记黄埔中药有限公司 | New purpose of traditional Chinese preparation for treating stomatitis |
| CN102225151A (en) * | 2011-06-15 | 2011-10-26 | 广州白云山和记黄埔中药有限公司 | New purpose of medicine for treating stomatitis |
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| CN103656284A (en) * | 2013-11-29 | 2014-03-26 | 周晨 | Traditional Chinese medicine formula for treating oral inflammation |
| CN105106081A (en) * | 2015-10-12 | 2015-12-02 | 浙江康德药业集团股份有限公司 | Chinese herbal toothpaste used for oral inflammation and preparation method of Chinese herbal toothpaste |
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| CN101129774B (en) * | 2007-09-21 | 2010-07-14 | 广州白云山和记黄埔中药有限公司 | Traditional Chinese medicine preparation for treating inflammation of oral cavity and method of producing the same |
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| CN101732561A (en) * | 2009-12-29 | 2010-06-16 | 重庆精鼎药材科技开发有限公司 | Health-care medicine used for preventing and treating chronic pharyngitis and preparation method thereof |
| CN102225150A (en) * | 2011-06-15 | 2011-10-26 | 广州白云山和记黄埔中药有限公司 | New purpose of traditional Chinese preparation for treating stomatitis |
| CN102225151A (en) * | 2011-06-15 | 2011-10-26 | 广州白云山和记黄埔中药有限公司 | New purpose of medicine for treating stomatitis |
| CN102225151B (en) * | 2011-06-15 | 2013-02-27 | 广州白云山和记黄埔中药有限公司 | New purpose of medicine for treating stomatitis |
| CN102920905A (en) * | 2012-11-16 | 2013-02-13 | 成都倍特药业有限公司 | Extracting method for effective component of kouyanqing capsule |
| CN103656284A (en) * | 2013-11-29 | 2014-03-26 | 周晨 | Traditional Chinese medicine formula for treating oral inflammation |
| CN105106081A (en) * | 2015-10-12 | 2015-12-02 | 浙江康德药业集团股份有限公司 | Chinese herbal toothpaste used for oral inflammation and preparation method of Chinese herbal toothpaste |
| CN105106081B (en) * | 2015-10-12 | 2017-11-10 | 浙江康德药业集团股份有限公司 | A kind of Chinese herbal toothpaste for oral inflammation and preparation method thereof |
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