CN1713882A - Dry type patches safe for gum - Google Patents

Abstract

Disclosed herein is a pair of dry type patches for teeth whitening, having a patch for upper teeth and a patch for lower teeth, in which the patch for upper teeth has a shape different from the patch for lower teeth, and each patch has a controlled width and shape such that the contact area of each patch with gums is minimized. In the patch for upper teeth, a central portio n covering right and left upper central incisors is widest. In the patch for lower teeth, either portion covering right and left lower canine teeth is widest. Since the dry type patches covers all the portions of the teeth whil e minimizing the contact area with gums, no or little irritation is caused and wearability is excellent.

Description

Dry type paster to safe for gum

Technical field

The present invention relates to not use dens supporter can be attached to dry type patches for teeth whitening on the tooth, it has the contact area shape that the zest to gingiva is cut to bone, and makes the wearer feel nature.Because patches for teeth whitening adheres to tooth securely, they can not disturb wearer's daily life, and can not come off from tooth easily between active stage as wearer's mouth of coughing and/or speak up.

Technical background

Along with people increase the interest that brightens its tooth, many dens supporter products that teeth whitening effect is provided in a short time have been available commercially.The product that these dens supporter products are divided into over-the-counter products (" OTC product ") substantially and need the dentist to write out a prescription.Can low price buy the OTC product, but it is reported that it has many problems.For example, because the OTC product adopts the dens supporter of single size and single shape, they are not suitable for the various sizes and the shape of user tooth, and because dens supporter is improper and be applied to gel on the dens supporter and too much cause zest to tooth.In addition, owing in use can taking place, the gel leakage has problem convenient and safety.And because most OTC products are all very showy thereby very difficultly use them in daily life.Therefore, the application of OTC product is limited, for example can only use at night.On the other hand, owing to need the product that the dentist writes out a prescription strictly to make according to the profile and the size of patient's tooth, therefore can be in the problem that solves the OTC product in a way, cost an arm and a leg and the patient need regularly see dentist's shortcoming but have.

In order to solve the problems referred to above of gel-filled (gel-filled) dens supporter product, to have developed the tooth whitening strips (strips) that need not to use dens supporter and having proposed many associated patent applications.

For example, U.S. Patent No. 5,310,563 (Curtis etc.) propose a kind of tooth whitening strips, and it contains the capsule by adopting silicon polymer encapsulation peroxide or various composition in putty-like (putty-like) material to obtain.This tooth whitening strips is derived from the elasticity of this putty-like material such as rubber to the adhesive force of tooth.Yet the shape to this whitening strips does not give significant concern.This whitening strips has a shortcoming, and promptly because peroxide is encapsulated to the putty-like material, although therefore this whitening strips is labelled to the same time cycle of tooth, its whitening effect is still relatively poor relatively.In addition, because the adhesive force between this whitening strips and tooth depends on elastic strength, therefore the stimulation to tooth can make this whitening strips separate from tooth as cough or with the collision of something in the oral cavity of tongue vigorous exercise, thereby this whitening strips recovers its original shape.

On the other hand, 3M has researched and developed and has not a kind ofly used dens supporter and only adopt the tooth whitening strips of gel retardation insert (gelretention insert).This gel retardation insert is for further strengthening adhesive force development product between gel and tooth, and has micro structure.Should have the micro structure that adopts PSA (pressure sensitive adhesive) in it and be dispersed with the teeth whitening composition as the gel retardation insert of tooth whitening strips.Yet, having the dens supporter that the gel retardation insert of water solublity micro structure is made as employing, this gel retardation insert is not confirmed to the effect of teeth whitening.Because most polymer as PSA use solvent such as dichloromethane or ethyl acetate etc. rather than water and the ethanol that is not suitable for dental products, thereby they are considered to be not suitable for directly be attached on the intraoral tooth.In addition, as under the situation of tooth whitening strips, this tooth whitening strips is considered to be not suitable for commercialization at acrylate copolymer that will be lower with peroxide compatible (wet PSA).

The U.S. Patent No. 6,419,906 of authorizing Colgate discloses a kind of tooth whitening strips that contains thermoplasticity ethylene oxide polymer and solid percarbonate as brightener for tooth.Yet because ethylene oxide polymer and peroxide highly compatible be but low to tooth adhesive force, this whitening strips is considered to wear poor performance.

Especially, P﹠amp; G makes this tooth whitening strips commercialization.Because this tooth whitening strips makes by the teeth whitening composition being applied to equably, thinly on thin and the elastic polyethylene band, does not use dens supporter, therefore can solve the problem of traditional dens supporter product.Because tooth whitening strips is a wet type, the intensity that this whitening strips adheres to tooth is not high.Therefore, this whitening strips can adhere to and peel off easily, but a shortcoming arranged, promptly when coughing and cachinnating its can not be in the required time attached to the desired position on, and can be easily from tooth, compare particularly with upper tooth that the tooth place of lower tooth comes off.As the patented product relevant with these whitening strips products, U.S. Patent No. 5,879, the whitening strips of 691 open tool fillets.After this tooth whitening strips of finding given shape is that brightener for tooth is attached to desired location in required time necessary, P﹠amp; G develops the band with different shape based on this discovery, and has submitted PCT patent disclosure WO 2001-014736 to.This tooth whitening strips has and can cover 4 labial teeths and 2 canine tooth outer surfaces and allow to expose the shape at two canine tooth tips.That is, this whitening strips is shaped as the tip that does not cover canine tooth.The example that the shape of this whitening strips is possible comprises the tetragon that has or do not have the trapezoidal of at least one staged limit or groove and have at least one staged limit, groove or recess.These shapes allow whitening strips and teeth whitening material to be attached to tooth well, and keep this state and not from wearer's tooth landing in one section long time.As from P﹠amp; Seen in the business-like tooth whitening strips product that G produces, this whitening strips product is applied to have relative large scale and less lower tooth rather than the upper tooth of degree of crook.Fig. 1 a and 1b are respectively Crest Whitestrip (P﹠amp; G) be used for the whitening strips of upper tooth and be used for the plane graph of the whitening strips of lower tooth.

Yet, although P﹠amp; The tooth whitening strips that G produces has the trapezoidal shape that 2 canine tooth tips are not covered by band, but because this whitening strips is a wet type, so its adhesive force to tooth is still bad.Therefore, be necessary to improve the bad problem of adhesive force.

The principal benefits of the dry type patches for teeth whitening that is proposed by inventor of the present invention is, when user with hands when release liner (release liner) is peeled off paster and is labelled to paster on the tooth, the adhesion composition that is contained in the adhesion layer can not be deposited on the position of not expecting that reaches on hand as face or lip because of the error of user.In addition, because this paster is a dry type, it can solve the safety problem that is caused by the high concentration of hydrogen oxide as brightener for tooth.That is, after being labelled to the dry doubling sheet on the tooth, by the moisture hydration of dental surface the time, a kind of glassy polymers provides the powerful adhesive force to tooth, and begins to discharge brightening agent.Therefore, this dry type paster is the safe dosage form of no use problem.

Yet although above-mentioned dry type patches for teeth whitening has these advantages and tooth is had good tack, when the contact of this paster contained gingiva than tooth higher level moisture, the high adhesion strength that causes in the hydro-combination process can produce zest to gingiva.

Summary of the invention

In view of the problem (as the zest that causes by contained humidity in the gingiva) of above-mentioned patches for teeth whitening and make the present invention to gingiva, and target of the present invention is the dry type patches for teeth whitening that is provided for upper tooth and lower tooth, wherein in order to minimize and the contacting of gingiva, the shape of paster and/or contact area forms according to the gingiva contour line between tooth and the gingiva (gum line).

In order to realize target of the present invention, providing a slice to be used for upper tooth and a slice, to be used for the dry type patches for teeth whitening of lower tooth right, wherein upper tooth paster has the shape different with lower tooth paster, and every paster and/or contact area have width and shape through adjusting, thereby make the contact area minimum of every paster and gingiva.Preferred covering mid portion right and upper left central incisor is the wideest in upper tooth paster, and preferred covering two parts right and the lower-left canine tooth are the wideest in lower tooth paster.

According to an aspect of the present invention, provide hydrophilic glassy polymers wherein to be used to comprise the dry type paster of each layer of active component layer.Because dry type paster of the present invention can provide fully contacting of brightener for tooth and stain that dental surface forms, so can obtain fabulous whitening effect in a short time.

The specific embodiment of the present invention can overcome the problem (as when being attached on the inner teeth gear of oral cavity to the intense stimulus of gingiva) of conventional dry type paster.Thereby, the specific embodiment of the present invention relate to wherein when being attached to paster on the tooth, make the area that contacts with gingiva minimize with reduce to the zest of gingiva and by using to the strong adhesive force of tooth so that be folded to the minimized shape of the area at tooth back, the latter is one of advantage of dry type paster.Therefore, specific embodiment more of the present invention provide the dry type teeth whitening that contains peroxide to paste, and it is well with the match profiles of tooth and make with contacting of gingiva and minimize.

The specific embodiment of the present invention relates to tooth had fabulous adhesive force and have the dry type teeth whitening that can reduce the shape of gingival irritation pastes.Preferred specific embodiments of the present invention is the dry type paster, and it can keep inherent advantage, and solves the shortcoming of traditional dry type paster simultaneously.In addition, the shape of paster contact area of the present invention forms according to the boundary line between tooth and gingiva (as the gingiva contour line), to minimize and to brighten root of the tooth when the gingiva contact area contacts.Therefore, because last central incisor is maximum and the longest in upper tooth, the preferred mid portion the wideest (projection) that covers right and upper left central incisor in upper tooth paster, and because the part maximum exposed in lower tooth of canine tooth, preferred two parts that cover right and lower-left canine tooth are the wideest and other parts are spill in lower tooth paster.

People wish that pure white tooth is because pure white tooth can increase confidence and can stay impression clearly in other people brain during talking.The teeth number of exposing when smiling or talk is generally totally 4～8 upper teeth and lower tooth.Some people wish to brighten the invisible rear surface of all teeth and the front surface that can see.Yet for most of people, the color of labial teeth is most important.Known, canine tooth other labial teeth relatively is more prone to painted.In addition, root of the tooth (near gingiva) is more prone to painted than cusp (away from gingiva).Also known when the tooth whitening products that contains peroxide is used to whitening teeth, upper tooth and cusp (away from gingiva) are more promptly brightened than lower tooth and root of the tooth.

The shape of dry type paster, or the contact area of dry type paster preferably contains peroxide and forms according to the contour line that covers root of the tooth when minimizing with the gingiva contact area at least.

Because usually as the peroxide of the brightener for tooth stain that forms of bleaching teeth surface not only, and the enamel of bleaching teeth and dentine, they have fabulous whitening effect as everyone knows.Yet, exist peroxide to infiltrate through the probability of gingiva.Though toxicity test proof peroxide safety, releasing stimulus in short time during peroxide contact gingiva.As the short-term zest that peroxide causes, common known dental hyperesthesia and gingival irritation.Known this zest is used when containing peroxide product after brushing teeth immediately can become serious.Also known when continue using peroxide product frequent releasing stimulus.In order to alleviate this short-term zest, should stop or reducing and use peroxide product with the gingiva contact area.Preferred peroxide product only causes slight zest or does not cause zest.As everyone knows, any effectively abirritate of product that contains low concentration and low content peroxide.Yet,, preferably suitably control the level of peroxide because the concentration of the whitening effect of tooth whitening products and peroxide and content are proportional.

The preferable shape of patches for teeth whitening can change according to the composition of paster specific embodiments and the specific embodiments of feature and/or paster contact area.For example, because typical wet type tooth whitening strips Crest Whitestrips (P﹠amp; G) adhesion strength is low, and it can be easily be attached to tooth and peels off from tooth in the required time.In addition, because the adhesion strength of this whitening strips is derived from a kind of adhesive polymer carbopol (Carbopol) gel that is contained in this whitening strips, so this whitening strips is not to there are differences between tooth and the adhesive force to the gingiva contact area.Yet, because a little less than the adhesion strength of this whitening strips, this whitening strips can because of various stimulations from loss of tooth.Therefore, preferably this whitening strips has the shape that is foldable to the tooth back that does not cover canine cusp.That is, this whitening strips preferably with this not from the front portion and the back of the mode tray covered teeth of loss of tooth.

On the other hand, when common dry type paster during by hydration, it has strong adhesion strength.Therefore, compare with tooth, the gingiva that contains higher level moisture at first adheres to securely by hydration and with paster.In addition, when keeping the state that adheres to tooth, be contained in peroxide in the paster and infiltrate through gingiva and cause more zest.In view of the foregoing, the contact area between preferred paster and gingiva minimizes.As mentioned above, because relative cusp seriously but brightens slowly near the root of the tooth variable color of gingiva, root of the tooth is preferably covered by this paster.This paster can have the back of fold line with tray covered teeth.Yet, because lower tooth frequently contacts with tongue, with regard to the property worn, preferred little folded part.Preferably, lower tooth paster contact area wide be 0.3～2cm, be preferably 0.5～1.5cm, thereby cover the anterior and part of lower tooth fully or not exclusively cover the back of lower tooth.If the contact area field width 2～4cm of lower tooth paster then can cover the front portion and the back of lower tooth fully.Identical with lower tooth paster, with regard to the property worn, the folded part of upper tooth paster is preferably less.Preferably, upper tooth paster contact area wide be 0.5～2.5cm, be preferably 0.7～1.5cm, thereby can cover the anterior and part of upper tooth fully or not exclusively cover the back of upper tooth.

The size of patches for teeth whitening and/or paster contact area can change according to the number and the size of tooth.No matter how are the number of tooth and position, all can use paster of the present invention.When with paster only attached to a tooth on the time, what the color of this tooth may be with other tooth is different, therefore not preferred this way.When paster being attached on all teeth, user must open mouth widely as far as possible so that paster is attached on the tooth, and this is very inconvenient.Therefore, the size of preferred paster is enough to cover 6 to 8 teeth that expose when smiling or speak.

This patches for teeth whitening can be the rectangular shape with same widths.Yet when width was adjusted to maximum tooth, this paster covered other denticle fully and touches the gingiva part.Perhaps, when width was adjusted to the tooth of intermediate sizes, this paster can not cover the root of big relatively tooth fully.

Because upper tooth and lower tooth are different aspect their size, profile and the curvature, so upper tooth paster preferably has the shape that is different from lower tooth paster.For example, because central incisor is maximum and the longest in upper tooth, therefore preferably make upper tooth paster in the wideest mode of core that covers right and upper left central incisor; Because the degree maximum that canine tooth exposes in lower tooth is preferably made lower tooth paster in the wideest mode of two parts that covers right and lower-left canine tooth.Many people's average upper tooth size is about 1cm, and the lower tooth size is about 0.9cm.Therefore, paster contact area of the present invention is preferably wide 0.8～1.5cm of upper tooth paster and the wide 0.6～1.5cm of lower tooth paster.

In view of aforementioned, because dry type paster of the present invention has fabulous adhesiveness to wearer's tooth, it can be from loss of tooth under the situation that does not apply external force.Therefore, the invention provides upper tooth and lower tooth dry type patches for teeth whitening, wherein paster contact area shape forms to minimize the zest of gingiva and to obtain fabulous whitening effect according to the boundary line between tooth and gingiva.

The principal benefits of dry type patches for teeth whitening of the present invention is for because these pasters have high adhesion strength after their hydrations, and the back that therefore can be tooth does not have under the situation of any folded part and is fixed on the sufficiently long time on the tooth.In addition, thus this dry type paster has for the wearer and provides contact area between nature sensation and paster and gingiva to be minimized and gingiva is not caused or only cause slight irritating benefit.And, thereby upper tooth paster can not contact the property worn that provides good with lower tooth paster.Yet because lower tooth paster can be by saliva dilution, it can be back from following odontoptosis in adhering to of short time.Lower tooth paster is under the situation of the folding consequently folded form paster of its parcel lower tooth in back therein, and saliva dilution reduces and lower tooth paster can be attached to lower tooth in the time of expectation.

In order to maximize the whitening effect of dry type patches for teeth whitening, preferably increase the time of contact between brightening agent and tooth stain, be preferably contact whole night.First kind of Medical-Dental Division Fan family who adopts fixing dens supporter is to be Application Design whole night with bleach product.Because the wet type patch products to tooth adhesive force a little less than, so they are unsuitable for using whole night.And owing to the strong adhesion of dry type patch products to tooth, so they are applicable to application whole night.With regard to the adhesion strength of improving, more preferably has the dry type patch products of folded part.

Because teeth whitening effect can improve in the environment of particularly sealing, therefore the folding dry type paster of expection can demonstrate fabulous whitening effect.

In order to increase, in this folding dry type paster, form cutting line (cut line) to the adhesion strength of tooth and the abnormal sensory that minimizes the wearer.More preferably, form wide cutting line to minimize the lap at the lower tooth back side.Since the fold domain at the tooth back side canine tooth or before tooth place relative narrower, so and the tooth place relative broad of the fold domain at the tooth back side behind canine tooth is wearer's paraesthesia or unhappy.Therefore, lower tooth paster preferably only covers the back side of canine tooth or tooth before.

In addition, the core that is preferable over upper tooth and lower tooth paster is made a groove.Being formed with of groove is beneficial to improve wears performance.When wearing this dry type paster, groove allows this paster to be mounted to the center line of tooth.Particularly, when groove was formed at mid portion central of upper tooth paster, the contact area of this paster and gingiva was minimized and has therefore been reduced zest to gingiva.

The patch shape of the preferred specific embodiments of the present invention is shown in Fig. 2 a to 6b.

Fig. 2 a and 2b are respectively the patches for teeth whitening that is used for upper tooth of a preferred embodiment of the present invention and are used for the plane graph of the patches for teeth whitening of lower tooth.Particularly, Fig. 2 a is the plane graph that is used for the patches for teeth whitening of upper tooth, and the mid portion that wherein covers last central incisor the most outstanding in the upper tooth is the wideest; Fig. 2 b is the plane graph that is used for the patches for teeth whitening of lower tooth, and the two parts that wherein cover right and lower-left canine tooth are the wideest.

Fig. 3 a and 3b are respectively the patches for teeth whitening that is used for upper tooth of another preferred specific embodiments of the present invention and are used for the plane graph of the patches for teeth whitening of lower tooth.Particularly, Fig. 3 a is the plane graph that is used for the patches for teeth whitening of upper tooth, and the mid portion that wherein covers last central incisor the most outstanding in the upper tooth is the wideest, and forms a groove so that be attached to upper tooth in the center of mid portion; Fig. 3 b is the plane graph that is used for the patches for teeth whitening of lower tooth, and the two parts that wherein cover right and lower-left canine tooth are the wideest, and forms a groove so that be attached to lower tooth in the center of mid portion.

Fig. 4 a and 4b are respectively the patches for teeth whitening that is used for upper tooth of another preferred specific embodiments of the present invention and are used for the plane graph of the patches for teeth whitening of lower tooth.Particularly, Fig. 4 a is the plane graph that is used for the patches for teeth whitening of upper tooth, the mid portion that wherein covers last central incisor the most outstanding in the upper tooth is the wideest, and a groove is formed at the center of mid portion so that be attached to upper tooth, and the part on both sides is extended to cover the back of upper tooth; Fig. 4 b is the plane graph that is used for the patches for teeth whitening of lower tooth, and the two parts that wherein cover right and lower-left canine tooth are the wideest, and a groove is formed at the center of mid portion so that be attached to lower tooth, and the part on both sides is extended to cover the back of lower tooth.

Fig. 5 a and 5b are respectively the patches for teeth whitening that is used for upper tooth of another preferred specific embodiments of the present invention and are used for the plane graph of the patches for teeth whitening of lower tooth.Particularly, Fig. 5 a is the plane graph that is used for the patches for teeth whitening of upper tooth, the mid portion that wherein covers last central incisor the most outstanding in the upper tooth is the wideest, a groove is formed at the center of mid portion so that be attached to upper tooth, the part on both sides is extended the back with the covering upper tooth, and forms cutting line and/or groove to be easy to be folded to the back of upper tooth in the office, folding part; Fig. 5 b is the plane graph that is used for the patches for teeth whitening of lower tooth, two parts of canine tooth are the wideest below wherein covering, one groove is formed at the center of mid portion so that be attached to lower tooth, the part on both sides is extended the back with the covering lower tooth, and forms cutting line and/or groove to be easy to be folded to the back of lower tooth in the office, folding part.

Fig. 6 a and 6b are respectively the patches for teeth whitening that is used for upper tooth of another preferred specific embodiments of the present invention and are used for the plane graph of the patches for teeth whitening of lower tooth.Particularly, Fig. 6 a is the plane graph that is used for the patches for teeth whitening of upper tooth, the mid portion that wherein covers last central incisor the most outstanding in the upper tooth is the wideest, one groove is formed at the center of mid portion so that be attached to upper tooth, the part on both sides is extended covering the back of upper tooth, and the recess that forms a lateral incisor size in the office, folding part is to be easy to be folded to the back of upper tooth; Fig. 6 b is the plane graph that is used for the patches for teeth whitening of lower tooth, two parts of canine tooth are the wideest below wherein covering, one groove is formed at the center of mid portion so that be attached to lower tooth, the part on both sides is extended covering the back of lower tooth, and the recess that forms a lateral incisor size in the office, folding part is to be easy to be folded to the back of lower tooth.

Will be appreciated that patches for teeth whitening of the present invention and/or contact area are not limited by the shape shown in above-mentioned each figure.Consider the profile of upper tooth, mid portion most probable contact gingiva.Given this reason, the long twice of groove that the groove that forms in the mid portion of upper tooth paster forms than the mid portion in lower tooth paster reducing the contact area of paster and gingiva, thereby allows to use more easily.The relative upper tooth degree of crook of lower tooth is bigger.When the cutting line of the office, folding part of lower tooth paster formation is too narrow, lap can occur at the back of lower tooth, thereby cause abnormal sensory and be not easy to using.Therefore, preferably form two or more wide cutting lines in the office, folding part of lower tooth paster.

In order to make dry type patches for teeth whitening of the present invention, adopt the hydrophilic glassy polymers to comprise adhesion layer, active material layer and other each layer, but do not comprise backing layer with formation.When adamantine layer was by hydration, the hydrophilic glassy polymers provided the strong adhesive force of tooth and discharges brightener for tooth in moistening oral cavity.

Do not use the patches for teeth whitening of dens supporter (as no dens supporter type) only just can demonstrate fabulous whitening effect by being attached to tooth.Yet, when paster comprises wet adhesion layer and particularly during the gel-type adhesion layer, paster can be stayed on hand the active substance or the adhesion substance of considerable amount (80% or more) in the release liner stripping process.And when the error owing to user makes the face of paster and user or lipped joint touch, the adhesion substance that is included in the adhesion layer will be stayed on face or the lip.And kind and content on brightener for tooth are decided, and may obtain bad consequence.Particularly, be used as brightener for tooth, therefore serious problem may take place owing to have the high concentration peroxide of fabulous bleaching effect.In contrast, active substance that comprises in the dry type paster of the present invention and adhesion substance are kept solid forms (lamellar or membranaceous) before hydration.When paster touches skin or when tooth is peeled off, only residual 0～10% a small amount of active substance and adhesion substance.So provable dry type paster safety of the present invention and easy to use.

The teeth whitening that does not have dens supporter pastes or brightens dens supporter and is required to have and the suitable good adhesion strength of mucomembranous adhesion agent that is used for the treatment of stomatitis, this mucomembranous adhesion agent for example is AFTACH (distributor: Dong-Wha Pharm.Ind.Co., Ltd., Korea S, manufacturer: TEIJIN, Japan) and Taisho-A (distributor: Taisho Pharmaceutical Co., Ltd., Japan, manufacturer: TEIYAKU, Japan).That is, they must have enough adhesion strengths to demonstrate expected effect in moistening oral cavity in the required time.In addition, even they are required to have the adhesion strength that also is unlikely to from loss of tooth under unexpected situation, as unexpected cough and raise a cry.And, preferred anodontia holder patches for teeth whitening or brighten dens supporter and before being attached to tooth, have weak adhesion strength.This is because too strong initial adherence intensity can have problems when release liner is peeled off with hands.

Dry type paster of the present invention can address the above problem easily.Dry type paster of the present invention had very weak adhesion strength before paster is by hydration.This dry type paster provides strong adhesion strength after hydration.Even this dry type paster is by hydration fully, it also can be peeled off with hands easily.If too strong, drink a large amount of water (gargle, brush teeth, drinking water or beverage) and promote it from loss of tooth to the adhesive force of tooth.Therefore, dry type paster of the present invention helps using easily.

Backing layer can contain water-insoluble and the fluid-tight polymer of making in order to prevent that paster from sticking to gingiva or tongue and distortion or being caused by saliva from the film of loss of tooth.

On the other hand, may exist as the peroxide of the brightener for tooth in the dry type patches for teeth whitening and pass in time and become problem of unstable.In order to solve the unstability of peroxide among the present invention, can use peroxide stabiliser, or not use peroxide stabiliser, but add the glassy polymers solution that has excellent compatibility with peroxide by regulating solvent ratios.Therefore, the invention provides a kind of novel paster, it uses the hydrophilic glassy polymers as the base polymer that uses peroxide as the adhesion layer of the dry type paster of brightener for tooth (base polymer), and by regulating alternative this peroxide stabiliser of glassy polymers solution that solvent ratios is added peroxide stabiliser or had excellent compatibility with peroxide.Novel paster of the present invention can guarantee stabilization of peroxide.

In order to strengthen the whitening effect of patches for teeth whitening of the present invention, polyphosphate can be with peroxide as brightener for tooth.

Thickness that can be by regulating paster or change the teeth whitening effect that active substance is controlled patches for teeth whitening of the present invention.Paster is in case by being worn, and just begins by hydration and becomes transparent.In addition, owing to do not have pattern (pattern) or cover (pocket) on the backing layer, so the wearer may observe the oxygen bubbles that is produced by peroxide in wearing process, thereby and can witness whitening effect.And, because it is transparent and unshowy to wear in the process paster, thereby do not influence the daily life of user.

Patches for teeth whitening of the present invention is a matrix type patch, and is used to be attached to and is not skin or mucosa but the adamantine layer of tooth, so that provide brightener for tooth with whitening teeth to dental surface in time enough.Below the explanation paster is attached to tooth and is contained in intramatrical brightener for tooth and is released into principle on the dental surface: in the transdermal drug delivery system field of tool time lag, proposed a kind of preparation capable of permeating skin that discharges medicine from the skin moisture evaporated that utilizes after it adheres to the scheduled time.More specifically, in preparation capable of permeating skin, provide a kind of impermeable barrier of medicine between drug-reservoir and skin attachment surface.When said preparation adhered to skin, this barrier was gradually by from the hydration of skin moisture evaporated, thereby increased its permeability to medicine.In this case, use the hydrophilic glassy polymers as the barrier material.In the present invention, use the material of hydrophilic glassy polymers as each layer of matrix type patch.By the structure of this paster, can prevent the release of brightening agent when paster being adhered to tooth in storage and with hands.After paster adhered to, this paster began by the moisture hydration of dental surface and therefore obtains adhesion strength, thereby discharges brightening agent.The hydrophilic glassy polymers is used as the material of each layer of matrix type patch.Therefore, according to a further aspect in the invention, the hydrophilic glassy polymers is used as the material of matrix type patch each except that backing layer layer.

For these purposes, the example that can be used for the glassy polymers in the adhesion layer of paster of the present invention comprises such as Gantrez AN 119, poly-alkyl vinyl ether-maleic acid of AN 139 and S-97 (PVM/MA copolymer), polyvinyl alcohol, polyacrylic acid, poloxamer 407 (Pluronic), polyvinylpyrrolidone-vinyl acetate copolymer (PVP/VA copolymer) as Luviskol VA and Plasdone S PVP/VA, polyvinylpyrrolidone (PVP, K-15～K-120), Onamer M 1 (Gafquat 755N), polyquaternary amine-39 (Merquat plus 3330), carbomer (carbopol), hydroxypropyl emthylcellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose, gelatin reaches the alginate as sodium alginate.Above-mentioned polymer can be used separately or use with their mixture.The solvent of these polymer comprises the mixture of water, ethanol or their various mixed proportions.

The paster that adheres on the tooth should adapt to the profile phase with tooth in enough pliable and tough deformable.Because some polymers flexible are poor, can add suitable plasticizer.This plasticizer is decided on the kind and the preparation of glassy polymers, but use polypropylene glycol usually, glycerol or Polyethylene Glycol be as plasticizer.

The brightener for tooth that is contained in the enamel adhesion layer can be selected from following group: hydrogen peroxide, urea peroxide, calper calcium peroxide, SODIUM PERCARBONATE, Dexol, hydrogen peroxide tetrasodium pyrophosphate (tetrasodium pyrophosphate peroxidate) and their mixture.Hydrogen peroxide tetrasodium pyrophosphate (TSPP-H ₂O ₂) be the additive compound of tetrasodium pyrophosphate and hydrogen peroxide, it has the character of tetrasodium pyrophosphate self and has aqueous solution or the character of the hydrogen peroxide of crystal state.Usually, but tetrasodium pyrophosphate stable peroxide hydrogen and do not change the intrinsic property of hydrogen peroxide.In other words, it can prevent to use separately the problem that hydrogen peroxide causes.Metal peroxy hydrogen enzyme (metalliccatalase), UV ray, oxidase, heat treatment etc. can quicken the decomposition of hydrogen peroxide, and the hydrogen peroxide tetrasodium pyrophosphate stablizes and show the intrinsic property and the function of hydrogen peroxide to above-mentioned substance and processing.In fact, the hydrogen peroxide tetrasodium pyrophosphate of using liquid, gel or pasty state uses hydrogen peroxide to demonstrate good time stability relatively separately under 40 ℃ of temperature.Yet,, still be difficult for making the peroxide in the paster to reach stable even use the hydrogen peroxide tetrasodium pyrophosphate.

Usually, peroxide known is owing to its good reactivity is difficult in patch products stable.And the compatibility of it and polymer is poor.The stability of product endoperoxide is with the type of product or prepare relevant.About the stability of product endoperoxide, many patents that relate to the stabilization of peroxideization of general gel, paste or solution state are arranged, and find that the some of them patent can guarantee the stability to a certain degree under the high temperature.Yet, do not have prompting about the stabilization of peroxideization in scumbling shop gel or paster.Similarly, the present inventor finds that after carrying out test of many times the problems referred to above can not rely on known peroxide stabiliser to solve.Now, the inventor is during the stabilizing agent of screening paster endoperoxide, find a kind of like this stabilizing agent, it can be used for can not damaging in the range of application of the present invention the fundamental property of paster of the present invention, and can improve paster endoperoxide in time stability at high temperature.Therefore, according to another aspect of the present invention, peroxide stabiliser and peroxide are together as brightener for tooth.

Can be used for the peroxide stabiliser that has an excellent compatibility with peroxide in the patches for teeth whitening of the present invention and be being selected from following group one or more: alkyl aryl sulfonic acid ester, alkyl sulfonate esters, alkyl carboxylates, the disulfonic acid alkyl diphenyl ether, span series is as span 20 (sorbitan mono-laurate), span 40 (anhydrous sorbitol monopalmitate), sorbester p18 (sorbitan monostearate), sorbester p17 (sorbitan monooleate) and sorbester p37 (sorbitan trioleate), and tween (POE sorbitan fatty acid ester) series.Below peroxide stabiliser is illustrated in greater detail.

Patches for teeth whitening of the present invention contains peroxide as main brightener for tooth.When paster only used brightener for tooth to make then in 40 ℃ of following storages, the content of paster endoperoxide was passed in time and is reduced.Thereby also the whitening effect in observation in vitro to paster is lower than new paster.For gel-type preparation, even when excessive polymer being used as film former and not adding peroxide stabiliser, peroxide loss in time also seldom.Even when said preparation has a small amount of peroxide, also can obtain stability and required effect by using a small amount of intercalating agent that is known as general peroxide stabiliser as EDTA or sodium citrate.The solvent of gel layer is evaporated with in the patches for teeth whitening that forms lamellar paster (sheet-shaped patch) therein, and when not adopting stabilizing agent in the preparation, its peroxide stability reduces with respect to gel-type preparation.Also observe, compare, add intercalating agent and cause the peroxide stability of paster to descend with the paster of no intercalating agent.In addition, even use because of the well-known Dequest phosphonate/ester of its good peroxide stablizing effect, the still peroxide stability that can not obtain being fit to.

As mentioned above, paster endoperoxide stability is with dosage form such as gel, liquid or sheet and different reasons can be explained with many modes.According to U.S. Patent No. 4,320,102, peroxide is described to can be by the decomposition of being changed places by the catalytic response light of little metal that comprises in the compositions.The data of report show and exist every liter of peroxide 0.1mg ferrum, 0.2mg copper, 0.1mg magnesium or 0.02mg chromium will cause the decomposition of peroxide.The sheet type paster that evaporation by solution-type or gel-type paster internal solvent forms can contain the metal of high concentration on the thin slice of paster.In addition, sheet type paster has big surface area, can allow to carry out from the teeth outwards the reaction of two-forty, has reduced stabilization of peroxide simultaneously.

Stabilizing agent that paster of the present invention contains is most to be surfactant or emulsifying agent, and they are considered to form micelle and to the stabilization of peroxide generation beneficial effect in the product.For example, this stabilizing agent can stop peroxide with the material of peroxide compatible difference between contact, when using the glassy polymers of spreadability difference, be scattered in brightening agent in the paster equably and allow to apply equably adhesion layer.In fact, it is found that the residual quantity of peroxide reduces in time when gel is applied on the big surf zone thinly, and the gel of the same composition that comprises in the container is stable under high relatively temperature.The inventor finds, because some hydrophilic glassy polymerss and peroxide have the good compatibility, the solution of the hydrophilic glassy polymers through adjusting solvent ratios is not used peroxide stabiliser stable peroxide thing fully.Therefore, the invention is not restricted to the combination of peroxide and peroxide stabiliser.Now, more detailed description is as follows.

(PVP is in the hydrophilic glassy polymers of K-15～K-120), Onamer M 1, polyquaternary amine-39, polyvinylpyrrolidone-vinyl acetate copolymer (PVP/VA copolymer) and peroxide highly compatible and soluble in water, ethanol or their mixture as polyvinylpyrrolidone.Therefore, can be 9: 1 to 0: 10 water and alcoholic acid mixture and do not use peroxide stabiliser to stablize peroxide in the paster by the application mix ratio.The excellent compatibility that it is believed that polyvinylpyrrolidone and peroxide comes from peroxide by stabilized with hydrogen bond formation complex with polyvinylpyrrolidone.Polyvinylpyrrolidone (PVP) is the most preferred hydrophilic glassy polymers of the active component layer that is applied to contain peroxide.In obtainable PVP, paster of the present invention is used K-15～K-120, and preferably uses K-90 (PVP).Owing to just with regard to the efficient of casting coating method production, need gel content higher, therefore more preferably K-30 (PVP).Preferably, this PVP has high relatively molecular weight, preferably is higher than approximately 500,000, more preferably is higher than about 1,000,000.In a preferred specific embodiments, the application molecular weight is 1,270,000 PVP.In addition, find peroxide and polymer such as polyquaternary amine highly compatible with quaternary ammonium structure.According to the present invention, answer water and alcoholic acid mixture solvent as adhesion substance.Be generally hydrophilic with the glassy polymers of peroxide highly compatible, and make them can not be coated to the surface of release liner or other sheet equably.This water and alcoholic acid mixture can address this is that, thereby form uniform lamella.Therefore, according to a further aspect in the invention, provide and contain peroxide and paste, wherein do not add peroxide stabiliser and make paster in high temperatures by regulating water and alcoholic acid ratio as brightener for tooth and with teeth whitening that peroxide has a glassy polymers of excellent compatibility.Equally, paster of the present invention also comprises plasticizer, thereby provides sufficient pliability for paster.The plasticizer that is fit to comprises propylene glycol, glycerol and Polyethylene Glycol, although it can change with the kind and the preparation of applied polymer.

In addition, the present invention can comprise the polyphosphate of the peroxide that is different from the main brightening agent of conduct as brightening auxiliary agent to strengthen whitening effect.Can be used for polyphosphate of the present invention comprises and is selected from following group one or more: tetrasodium pyrophosphate (TSPP), sodium acid pyrophosphate (SAPP), sodium hexameta phosphate (SHMP), Sodium triphosphate (STP), Sodium triphosphate potassium (SKTP), tetrapotassium pyrophosphate (TKPP), acid sodium phosphate on the high side (Sporix) and acid sodium polyphosphate (Multiphos).Usually, well-known polyphosphate can be effectively as the tartar controlling agent in the toothpaste with the formation that suppresses tartar or remove tartar.Because it can remove the stain that is formed on the dental surface effectively, particularly those are derived from the stain that forms as metals such as ferrum, calcium, magnesium of food or working environment, also known polyphosphate is the good intercalating agent that can strengthen teeth whitening effect to a certain extent.Find that polyphosphate is applied to can suppress the formation of tartar and remove tartar by the time of contact that prolongs tooth and polyphosphate in the paster of the present invention with peroxide.In fact, found when paster of the present invention is adhered to tooth that it is clean that dental surface and diastema become.

The polymer that can be used for matrix type patch backing layer of the present invention comprises polyvinyl acetate; ethyl cellulose; polymethyl methacrylate; produce the methacryl betanin/methacrylic acid copolymer that can trade name Yukaformer be purchased by Mitsubishi; as Eudragit L 100; Eudragit L 125; Eudragit L 100-55; the methacrylic acid copolymer of Eudragit L 30D-55; as Eudragit E 100; Eudragit E 125; Eudragit RL 100; the aminoalkyl methacrylate ester copolymer of Eudragit RL 30D, CAP; Lac and their mixture.In addition, can be applicable to the undissolved polymer under 8 conditions of pH6 in the oral cavity as enteric-coating material.

For obtaining enough pliabilities, the backing layer that teeth whitening of the present invention pastes can comprise various plasticizers.In the case, comprise the plasticizer of the numerous species of above-mentioned plasticizer, can use according to employed solvent types as propylene glycol, glycerol, Polyethylene Glycol.For example, can also use Oleum Ricini or castor oil hydrogenated.

And, when paster of the present invention is adhered to tooth, in order to make tooth because physics and chemical reaction and obviously brighten can be used any Chinese white in backing layer.For example, titanium dioxide, Talcum, hydroxyapatite, zinc oxide or their mixture can be used as Chinese white.When these pigment with as the peroxide incompatible of brightening agent the time, can use surface treated titanium dioxide.In addition, also can sample application Margarita material or versicolor pigment according to the individual.

According to the present invention, can be used alone or as a mixture the material that can not be used for traditional toothpaste because they are unstable in time as enzyme, particularly glucanase or glucoseoxidase.Also can add known papain with teeth whitening effect.Can use treatment oral diseases such as triclosan, chlorhexidine, vitamin E or derivatives thereof such as Vitamin E acetate, the oxidant that can effectively treat halitosis, chlorophyll or derivatives thereof, spice.

Using the method for patches for teeth whitening of the present invention to comprise adheres to this paster on the tooth that need brighten.This paster is made up of water-soluble portion and water-insoluble part (backing layer).This water-soluble portion directly contacts with dental surface, and backing layer plays protective bulkhead.Along with the hydration of dry type patches for teeth whitening, its pliability and adhesion strength increase.If dental surface is too dried, has then just begun paster and can not be attached to dental surface.Even because only there is being in the presence of the small amount of moisture this paster also can be, so as long as dental surface is not very dry with regard to can not having special problem by hydration fully.In addition, greatly reduce the adhesion strength of this paster owing to too much moisture rapidly dissolvable hydrophilic glassy polymers.Therefore, during wearing patches for teeth whitening, should not drink a large amount of water or beverage.

Particularly, at first, user places paster the mid portion of tooth and makes it be close to dental surface with finger.At this moment, preferably make it be close to space between adjacent teeth with finger and tongue.

Patches for teeth whitening of the present invention can come off from tooth after 30 minutes to 1 hour naturally in adhering to tooth.Occasionally, this paster even after the long duration, can not come off easily.Yet coming off naturally needs more time.In this case, there is not the problem of secure context and strengthened results of tooth whitening on the contrary.If need, wearer's available water is peeled off this paster easily.

Because patches for teeth whitening of the present invention can guarantee that peroxide fully contacts in the required time with the tooth stain, its effect to whitening teeth is remarkable, but can not be fully provides as the pure and fresh sensation due to the toothpaste to the wearer.Given this reason, the wearer can brush teeth after peeling off paster.Yet, do not brush teeth before not advising adhering to paster owing to can cause the tooth zest.

Description of drawings

Can more be expressly understood above-mentioned and other purpose, feature and other benefit of the present invention by following detailed description of the accompanying drawings, wherein:

Fig. 1 a and 1b are respectively Crest Whitestrip (P﹠amp; G) the upper tooth whitening strips and the plane graph of lower tooth whitening strips;

Fig. 2 a and 2b are respectively the patches for teeth whitening that is used for upper tooth of a preferred embodiment of the present invention and are used for the plane graph of the patches for teeth whitening of lower tooth.Particularly, Fig. 2 a is the plane graph that is used for the patches for teeth whitening of upper tooth, and wherein, the mid portion that covers last central incisor the most outstanding in the upper tooth is the wideest; Fig. 2 b is the plane graph that is used for the patches for teeth whitening of lower tooth, and the two parts that wherein cover right and lower-left canine tooth are the wideest.

Fig. 3 a and 3b are respectively the patches for teeth whitening that is used for upper tooth of another preferred specific embodiments of the present invention and are used for the plane graph of the patches for teeth whitening of lower tooth.Particularly, Fig. 3 a is the plane graph that is used for the patches for teeth whitening of upper tooth, and the mid portion that wherein covers last central incisor the most outstanding in the upper tooth is the wideest, and forms a groove so that be attached to upper tooth in the center of mid portion; Fig. 3 b is the plane graph that is used for the patches for teeth whitening of lower tooth, and the two parts that wherein cover right and lower-left canine tooth are the wideest, and forms a groove so that be attached to lower tooth in the center of mid portion.

Fig. 4 a and 4b are respectively the patches for teeth whitening that is used for upper tooth of another preferred specific embodiments of the present invention and are used for the plane graph of the patches for teeth whitening of lower tooth.Particularly, Fig. 4 a is the plane graph that is used for the patches for teeth whitening of upper tooth, the mid portion that wherein covers last central incisor the most outstanding in the upper tooth is the wideest, and a groove is formed at the center of mid portion so that be attached to upper tooth, and the part on both sides is extended to cover the back of upper tooth; Fig. 4 b is the plane graph that is used for the patches for teeth whitening of lower tooth, and the two parts that wherein cover right and lower-left canine tooth are the wideest, and a groove is formed at the center of mid portion so that be attached to lower tooth, and the part on both sides is extended to cover the back of lower tooth.

Fig. 5 a and 5b are respectively the patches for teeth whitening that is used for upper tooth of another preferred specific embodiments of the present invention and are used for the plane graph of the patches for teeth whitening of lower tooth.Particularly, Fig. 5 a is the plane graph that is used for the patches for teeth whitening of upper tooth, the mid portion that wherein covers last central incisor the most outstanding in the upper tooth is the wideest, a groove is formed at the center of mid portion so that be attached to upper tooth, the part on both sides is extended the back with the covering upper tooth, and forms cutting line and/or groove to be easy to be folded to the back of upper tooth in the office, folding part; Fig. 5 b is the plane graph that is used for the patches for teeth whitening of lower tooth, two parts of canine tooth are the wideest below wherein covering, one groove is formed at the center of mid portion so that be attached to lower tooth, the part on both sides is extended the back with the covering lower tooth, and forms cutting line and/or groove to be easy to be folded to the back of lower tooth in the office, folding part.

Fig. 6 a and 6b are respectively the patches for teeth whitening that is used for upper tooth of another preferred specific embodiments of the present invention and are used for the plane graph of the patches for teeth whitening of lower tooth.Particularly, Fig. 6 a is the plane graph that is used for the patches for teeth whitening of upper tooth, the mid portion that wherein covers last central incisor the most outstanding in the upper tooth is the wideest, one groove is formed at the center of mid portion so that be attached to upper tooth, the part on both sides is extended covering the back of upper tooth, and the recess that forms a lateral incisor size in the office, folding part is to be easy to be folded to the back of upper tooth; Fig. 6 b is the plane graph that is used for the patches for teeth whitening of lower tooth, two parts of canine tooth are the wideest below wherein covering, one groove is formed at the center of mid portion so that be attached to lower tooth, the part on both sides is extended covering the back of lower tooth, and the recess that forms a lateral incisor size in the office, folding part is to be easy to be folded to the back of lower tooth.

Specific embodiments

Hereinafter, will be described in greater detail the present invention with reference to the following example.Yet it is for the purpose of illustration that these embodiment are provided, and can not be considered to limitation of the scope of the invention.

Embodiment 1 to 5, comparative example 1

According to following compositions, the teeth whitening of preparation embodiment 1 to 5 and comparative example pastes.

[embodiment 1]

Be used to prepare the solution of the adhesion layer that contains active substance

Add in the mixture that adds water to 10% polyvinyl alcohol, 10% polyvinylpyrrolidone, 5% hydrogen peroxide tetrasodium pyrophosphate, 2% alkyl aryl sulfonic acid ester (SLS) and 3% glycerol, reach 100% until total amount.

Be used to prepare the solution of backing layer

Add in the mixture of ethanol to 8% ethyl cellulose, 5%Eudragit and 4% Oleum Ricini, reach 100% until total amount.

[embodiment 2]

Be used to prepare the solution of adhesion layer

Reach 100% until total amount in the hydroxypropyl cellulose of interpolation ethanol to 30%.

Be used to prepare the solution of active material layer

Add adding water in 20% polyvinylpyrrolidone, 5% hydrogen peroxide, 10% glycerol and the 30% alcoholic acid mixture, reach 100% until total amount.

Be used to prepare the solution of backing layer

Add in the mixture of ethanol to 5% polyvinyl acetate, 5%Yukaformer (Mitsubishi) and 6% glycerol, reach 100% until total amount.

[embodiment 3]

Be used to prepare the solution of the adhesion layer that contains active substance

Add adding water in 10% polyquaternary amine-39,10% urea peroxide and the 50% alcoholic acid mixture, reach 100% until total amount.

Be used to prepare the solution of backing layer

Mixed solution (acetone=4/1) is added in the mixture of 30% CAP and 4% Oleum Ricini, reaches 100% until total amount.

[embodiment 4]

Be used to prepare the solution of adhesion layer

Reach 100% until total amount in the polyvinylpyrrolidone of interpolation ethanol to 20%.

Be used to prepare the solution of active material layer

Add in the mixture that adds water to 12% poly-alkyl vinyl ether-maleic acid (Grantrez S 97) and 6% hydrogen peroxide tetrasodium pyrophosphate and 0.5% sorbitan monooleate, reach 100% until total amount.

Be used to prepare the solution of backing layer

Add in the mixture of ethanol to 10% ethyl cellulose and 6% Oleum Ricini, reach 100% until total amount.

[embodiment 5]

Be used to prepare the solution of adhesion layer

Add adding water in 10% polyvinyl alcohol, 10% polyvinylpyrrolidone and 3% glycerol, reach 100% until total amount.

Be used to prepare the solution of active material layer

Add in the mixture that adds water to 20% Onamer M 1,4%PC, 4%TKPP and 2% sorbitan mono-laurate, reach 100% until total amount.

Be used to prepare the solution of backing layer

Add ethanol to the mixture of 15%Eudragit and 5% Polyethylene Glycol, reach 100% until total amount.

[comparative example 1]

Be used to prepare the gel of the adhesion layer that contains active substance

Add in the mixture that adds water to 12% carbopol, 4.5% hydrogen peroxide, 0.48%SAPP and 80% glycerol, reach 100% until total amount.

Backing layer

The polyethylene band

More than the abbreviation of Shi Yonging has following meaning.

TKPP: tetrapotassium pyrophosphate, SAPP: sodium acid pyrophosphate, TSPP: tetrasodium pyrophosphate

[experimental example 1]

The gingival irritation evaluation

With reference to accompanying drawing, Fig. 1 a, 2a, 3a, 4a, 5a and 6a are upper tooth paster.These pasters are made by the corresponding preparations that obtains in the Application Example 1.Respectively, the paster unfolded part shown in Fig. 2 a, the paster shown in Fig. 4 a has folded part but not have cutting line, and Fig. 5 a and 6a have folded part and cutting line, Fig. 1 a is depicted as Crest Whitestrip (P﹠amp; G, U.S.) upper tooth whitening strips.Whitening strips shown in Fig. 1 a is made by the corresponding preparations of using comparative example 1 acquisition.As shown in Figure 1a, this whitening strips has folded part and is rectilinear form.

Wear these pasters after 30 minutes twice continuing for 2 every days in week, measure the paster made thus to the degree of gingival irritation and wear performance.In addition, measure after one hour and hold viscosity (adhesion maintenance) this paster being adhered to tooth.Give the above-mentioned feature marking of paster based on following standard.5: very satisfied (nonirritant, the tooth adhesion is very strong, it is very outstanding to hold viscosity), 4: satisfied (do not have or minimal irritation, the tooth adhesion is strong, hold viscosity outstanding), 3: medium (slight zest, the tooth adhesion is medium, it is medium to hold viscosity), 2: dissatisfied (incipient stage has zest, a little less than the tooth adhesion, it is not good to hold viscosity), 1: very dissatisfied (have lasting zest in the use, the tooth adhesion very a little less than, hold the viscosity extreme difference).

Paster shown in Fig. 1 a, 2a, 3a, 4a, 5a and the 6a has the length that is enough to cover 6 to 8 teeth.In 10 people, measure the degree to gingival irritation, the property worn of these pasters and hold viscosity.The result is as shown in table 1.

Table 1

	Stimulation degree to gingiva	Wear performance	The tooth degree of adhesion	Hold viscosity
					Fig. 2 a	??4.5	??4	??5	??3
Fig. 3 a	??4	??3	??4	??5
					Fig. 4 a	??4	??4	??4	??5
Fig. 5 a	??4	??4	??4	??5
					Fig. 6 a	??4	??4	??4	??5
Fig. 1 a	??3	??3	??3	??2

As seen from Table 1, although Fig. 2 is a, the paster shown in 3a, 4a, 5a and the 6a is the formulation preparation by embodiment 1, but the non-folded form paster of Fig. 2 a the most outstanding in gingival irritation mensuration (as the zest minimum), and compare with the non-folded form paster of Fig. 2 a, the folded form paster of Fig. 3 a, 4a, 5a and 6a is outstanding in holding viscosity mensuration.Therefore infer, when wearing 30 minutes or during the longer time preferred folded form paster.Conclusion is, the gingival irritation of paster, wears performance and holds the type (wet or do) that viscosity depends on paster.The physical property of dry type paster depends on the shape (folding or non-folding) of this dry type paster.

[test example 2]

Measure the adhesion strength of patches for teeth whitening according to following mechanical means to tooth.

(1) preparation of hydroxyapatite (HAP) tablet samples

(IR press) forms hydroxyapatite powder in tablet by the IR press.The gained tablet is calcined down at 1000 ℃.

(2) to the evaluation of the adhesion strength of tooth

Using miniature tension test instrument to measure paster adheres to as the adhesion strength on the hydroxyapatite of artificial teeth material.The result is as shown in table 2 below.Will be through measuring the adhesion strength under the drying regime behind the incinerating hydroxyapatite sample finish-drying.Water being added to fully the moisture of after this sample complete wetting, removing sample surfaces through incinerating hydroxyapatite sample then, measure the adhesion strength under the wetting state afterwards.Why set up wetting conditions and be because the oral cavity is moist but dental surface does not have moistening to being enough to find moisture.Paster is depressed on the sample in the constant time with constant force, measures and peel off the needed power of accompanying paster, thereby obtain the adhesion strength that paster adheres to tooth.The replication several times.The result is as shown in table 2.

Table 2

	Adhesion strength under the drying regime	Adhesion strength under the wetting state
			Embodiment 1	??0.8	??205.9
Embodiment 2	??24.3	??85.75
			Embodiment 3	??40.0	??105.5
Embodiment 4	??17.0	??160.2
			Embodiment 5	??22.1	??114.0
Comparative example 1	??38.0	??39.5

As shown in table 2, the dry type paster of embodiment 1-5 demonstrates than adhesion strength high 2～260 times under the wetting state under drying regime.On the other hand, the wet type paster that is coated with gel on its of comparative example 1 does not have significant difference between the adhesion strength under wetting state and the drying regime.

Industrial applicability

Obviously as shown in the above description, patches for teeth whitening of the present invention be wherein the hydrophilic glassy polymers as the dry type paster of the material of other each layers except that backing layer.After this dry type paster was attached on the tooth, this glassy polymers provided the strong adhesion that adheres to tooth in by the moisture hydration of dental surface, and brightening agent begins to discharge.Therefore, this dry type paster is in use no problem safe dosage form.In addition, although this dry type paster contacts with hands or other positions, it does not stay any residue, and this provides convenience in application.And because this dry type paster has high adhesion to tooth, therefore it can not have fabulous whitening effect from loss of tooth in wearing process.In addition, because the contact area 100 of this dry type paster has covered all parts of tooth, make simultaneously with contacting of gingiva to minimize, thereby do not cause or only cause minimal irritation and wear performance splendid.

Although disclose the preferred embodiments of the disclosure for exemplary purposes, those skilled in the art will recognize that, can make various improvement, interpolation or replacement under the disclosed scope and spirit condition of the present invention not deviating from as appended claims.

Claims (12)

1, it is right to have a dry type patches for teeth whitening of upper tooth paster and lower tooth paster, wherein upper tooth paster is different with the shape of lower tooth paster, thereby and each paster width and the shape that all have through adjusting make that the contact area of each paster and gingiva is minimized.

2, dry type patches for teeth whitening as claimed in claim 1 is right, and wherein said upper tooth paster covering mid portion right and upper left central incisor is the wideest, and described lower tooth paster covering two parts right and the lower-left canine tooth are the wideest.

3, dry type patches for teeth whitening as claimed in claim 1 or 2 is right, and wherein said paster doubles by the water hydration time to the adhesion strength to tooth.

4, dry type patches for teeth whitening as claimed in claim 1 or 2 is right, and wherein said paster is to comprising peroxide as brightener for tooth and hydrophilic glassy polymers.

5, dry type patches for teeth whitening as claimed in claim 4 is right, and wherein said paster is to also comprising peroxide stabiliser together with peroxide.

6, dry type patches for teeth whitening as claimed in claim 1 or 2 is right, and wherein the size of the width of each paster and tooth is similar, thereby can not fold into the back side of tooth.

7, dry type patches for teeth whitening as claimed in claim 1 or 2 is right, and wherein each paster all folds into the back side of tooth and has cutting line so that can be folded to the back side of tooth easily at folded part.

8, dry type patches for teeth whitening as claimed in claim 1 or 2 is right, the wide 0.5～2.5cm of wherein said upper tooth paster, the wide 0.3～2.0cm of described lower tooth paster.

9, dry type patches for teeth whitening as claimed in claim 8 is right, the wide 0.7～1.5cm of wherein said upper tooth paster, and Breadth Maximum is 0.8～1.5cm.

10, dry type patches for teeth whitening as claimed in claim 8 is right, the wide 0.5～1.5cm of wherein said lower tooth paster, and Breadth Maximum is 0.6～1.5cm.

11, dry type patches for teeth whitening as claimed in claim 1 is right, and wherein said paster is to comprising the water-insoluble outermost layer.

12, dry type patches for teeth whitening as claimed in claim 1 is right, and wherein said upper tooth paster and/or lower tooth paster are included in the groove that forms with the centre of gingiva contact portion.

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