KR100497004B1 - Dry type patches safe for gum - Google Patents

Abstract

The present invention relates to a dry type tooth whitening patch, wherein the upper teeth and the lower teeth are different in shape and have a height and a shape such that the area in contact with the gum is minimized. The height of the middle part corresponding to the highest), and the lower teeth for the tooth whitening patch of the present invention having the highest height of both ends corresponding to the canine (mandibular left and right canine) part, the irritation of the gums is minimized. While it has a form that completely covers the entire part of the teeth, it has a low irritation and good fit.

Description

Dry type tooth whitening patch with minimal gum irritation {DRY TYPE PATCHES SAFE FOR GUM}

The present invention in a dry type tooth whitening patch that makes the teeth white by simply attaching it to the teeth without using a tray, while minimizing the irritation of the gums and minimizing foreign body feelings. The present invention relates to a tooth whitening patch having a form that is more convenient for use because it has sufficient adhesion to the teeth and is not inconvenient to daily life and does not separate from the teeth even when coughing or making a loud sound.

Recently, with increasing interest in teeth whitening, a lot of tray products that can see the teeth whitening effect in a short time have been sold. These tray products are largely divided into OTC products and those requiring a doctor's prescription. The former has the advantage that it can be purchased at a pharmacy or a large supermarket and is inexpensive, while the tray is generally made of the same size and shape, so it does not fit well with each tooth, so In addition to the irritation caused by the excessive use of the gel applied to the tray, it is known that there are various problems in safety in addition to the inconvenience caused by the leakage of the gel during use. In addition, in most cases it is difficult to use during everyday life because it is noticeable to others when attached to the general use is limited to use at bedtime. On the other hand, products that require a doctor's prescription measure the shape or size of the patient's teeth and order them for personal use, so the trays are manufactured with the correct size and shape. It is a hassle to visit a doctor.

Recently, many patents have been filed for tooth whitening adhesives that do not use trays to solve these problems. Curtis et al., U.S. Patent No. 5,310,563, discloses a tooth whitening agent that encapsulates and adds a peroxide or various potent ingredients to a material such as a putty using a silicone polymer. In this case, the force that the tooth whitening adhesive adheres to the teeth is caused by the elasticity of the putty material such as rubber, and there is no mention of shape. However, the tooth whitening adhesive using a substance such as putty has a disadvantage in that the whitening effect is relatively low even if it is attached to the tooth at the same time because the peroxide is encapsulated. In addition, the tongue movement depends on the elastic force alone. In many mouths, if the bend is attached to a severely curved tooth and is stimulated by a certain stimulus, for example, where it hits or coughs, it is likely to be separated from the tooth and recover to its original shape.

Meanwhile, 3M applies a gel retention insert with a microstructure that has been developed and used to further enhance the adhesion between gel and teeth to tooth whitening products (Zaris) using conventional trays. Tooth whitening adhesives have been developed that use only gel retaining inserts without the use of trays. In this case, a gel retaining insert with a microstructure made by using pressure sensitive adhesive (PSA) and dispersing tooth whitening ingredients is used as a tooth whitening adhesive. A tray is used by applying a gel retaining insert having a microstructure insoluble in water. It has not been tested for whitening effects (as most polymers used in PSA use solvents that cannot be used in oral products rather than water or alcohol, such as methylene chloride, ethyl acetate, etc.). It is thought that there is an inadequate aspect to commercialize the acrylic polymer which has an inadequate surface-attachment, and the acrylic polymer capable of wet PSA is incompatible with peroxide when used as an adhesive for whitening teeth.

Colgate also developed an adhesive for whitening teeth using US Pat. No. 6,419,906 for tooth whitening adhesives, using thermoplastic ethylene oxide polymers and solid percarbonates as whitening agents. However, polyethylene is considered to have a problem of poor fit because of excellent compatibility with peroxides but low tooth adhesion.

In particular, P & G commercializes and sells these teeth whitening strips. The tooth whitening strips sold by P & G solve the problem of tray products by applying thin and uniform tooth whitening ingredients to thin and flexible polyethylene strips without using trays. However, P & G's product is a wet type, which has the advantage that the adhesion between the tooth and the product is not so strong that it is easy to attach or detach, whereas severe impacts such as coughing or There is a disadvantage in that it is not attached to a desired position for a desired time due to the impact of laughing out loud. This phenomenon is known to occur more in the lower teeth than the upper teeth. A patented product developed by P & G in connection with these products, the shape of which has an initial rounded corner (USP 5,879,691), and then the shape of the tooth whitening strip is important for attaching the tooth whitening agent to the desired area for the desired time. It was found that the related patent WO2001-014736 was filed. The tooth whitening strip is shaped to cover at least four front teeth and two canine fronts of the user, the biggest feature being that they do not cover the ends of the two canines. In other words, the strip may be shaped so that the canine protrudes. Possible shapes include trapezoids with or without stepped sides or notches, and quadrangles with grooves, stepped sides, or recesses. By having this good shape, the teeth whitening strips and materials are better adhered to the teeth and, in an improved shape, remain on the user's teeth without slipping for longer periods of time. In fact, as seen in P & G's tooth whitening strips, this shape appears to be applied to the lower teeth rather than the upper teeth, which are relatively large in size and smooth in flexion. 1A and 1B are plan views showing upper and lower teeth forms of the Crest Whitestrip of P & G, respectively.

However, P & G's tooth whitening strip has a room for improvement in that it is a wet type even if the trapezoid does not cover the ends of two canines.

Advantages of the dry type tooth whitening patch previously filed by the present inventors are that even when the adhesive layer adheres to the hand when the patch is detached from the release liner by hand, the adhesive component does not remain and the face does not remain. If you accidentally touch an unwanted area such as your face or lips, it is convenient because it does not ask. In addition, the human safety part, which may be caused by containing a high concentration of peroxide as a whitening agent, is more preferably a dry type in which the whitening component does not adhere to the hands or skin. In other words, the dry type is a safer formulation in which a glassy polymer is hydrated by moisture on the surface of a tooth, which is a desired area, and thus a strong adhesive force is generated and a whitening agent is released.

However, the dry type tooth whitening patch having such many advantages is excellent in adhesion after hydration, but there is no problem during the attachment. There is a possibility that a strong adhesive force generated in the process of hydration increases the irritation to the gums, so a solution is required.

The present invention is to solve the problem that the dry type teeth whitening patch may be irritated by the moisture of the gums, dry type and upper teeth and lower teeth to maximize the curve of the teeth in order to minimize contact with the gums An object of the present invention is to provide a tooth whitening patch.

In order to achieve the above object, in the dry tooth whitening patch of the dry type, the teeth of the dry type, characterized in that the upper teeth and lower teeth for the shape, and has a height and shape to minimize the area in contact with the gums Provides a whitening patch.

Here, the shape of the tooth whitening patch is the highest in the middle portion corresponding to the middle incisor (upper left and right middle incisor) for the upper teeth, and the height of both ends corresponding to the canine (lower left and right fangs) for the lower teeth High is preferred.

The present invention relates to a dry type patch using a hydrophilic glassy polymer as the main polymer in several layers including a drug layer, which provides a time for the tooth whitening agent to sufficiently contact the stain on the tooth surface. To provide a whitening patch excellent tooth whitening effect can be used for a short period of time.

In the present invention, as mentioned above, as a result of the study to compensate for the disadvantage of the dry type tends to have a lot of strength and relatively strong stimulation is felt as the contact with the gum when attached to the teeth in the oral cavity, the teeth Discovered the importance of whitening patch shapes. Accordingly, by minimizing the area where the tooth whitening patch is in contact with the gum when it is attached to the teeth, less irritation is reduced, and by using the strong adhesive force, which is an advantage of the dry type, it forms an improved form that minimizes the area to be folded in the back of the tooth. Thus, the study was conducted to feel comfortable during the attachment time. As a result, according to the present invention, there is provided a dry type tooth whitening patch containing peroxide, which has a shape that fits well with the teeth and minimizes contact with the gums.

The present invention relates to a dry type tooth whitening patch having a good adhesion to teeth while having a low gum irritation shape. In other words, it is a shape to maximize the advantages of the dry type patch while compensating for the disadvantages. In order to minimize contact with the gums and whiten the roots of the teeth, it is necessary to have a shape that utilizes the bend of the teeth and the contact area of the gums. There is. According to this, the upper teeth have a large and high anterior teeth (upper left and right middle incisors), and in the case of the lines where the gums and teeth touch, the middle is preferably convex, and the lower teeth have the most teeth (fangs) protruding from the gums so that the gums and teeth touch the teeth. It is more preferable that the center part is concave, and the end part which is a part which touches a canine is convex.

The biggest reason people want their teeth to be white is when they have white teeth, they feel confident in talking with others and they look more refined. The teeth that are revealed to other people when laughing or speaking are generally at least 4 to 8 teeth, both upper and lower teeth, among those who want to look white as well as the entire tooth and the visible front, as well as the back of the invisible tooth. Although, the tooth color is particularly important for these displacers. In general, most of people's teeth are more pigmented than canine teeth, and the upper part of the tooth (root) that touches the gum is known to be more pigmented than the tip of the tooth (the part that does not touch the gum). In addition, when a tooth whitening product containing peroxide is used, the upper teeth than the lower teeth, and the tip of the teeth (the parts not touching the gums) are relatively well whitened when viewed from one tooth.

The most preferred shape for tooth whitening patches containing dry peroxides is to match the curve of the teeth to cover the roots of the teeth while minimizing contact with the gums.

Peroxide, which is mainly used as a tooth whitening agent, is known to have excellent whitening effect because it not only bleaches the color of the tooth surface, but also penetrates and bleaches into the enamel and dentin of the tooth. On the other hand, these peroxides can also penetrate the gums, so even if they are found to be safe in the toxicity assessment, they can cause temporary irritation if they touch the gums. The most common transient stimuli that can be caused by peroxides are tooth sensitivity and gingival irritation. These irritations are known to occur more often with peroxide-containing products immediately after brushing, and are more likely to occur with continuous use of peroxide-containing products. Such stimuli are temporary, and are known to disappear when the number of times of use or the use is stopped for a while, but it is desirable to prevent such stimuli from occurring. There are many ways to reduce these stimuli, but in general, the lower the concentration of peroxide, the lower the content of peroxide is known to be effective. However, the tooth whitening effect by the tooth whitening product is effective as the concentration of the peroxide is higher and the content is higher, so it is necessary to set an appropriate level.

The preferred shape of the tooth whitening patch may vary depending on the composition or properties of the tooth whitening patch. For example, P & G's Crest Whitestrips, a typical wet-type tooth whitening strip, have the advantage of being easy to attach and detachable at the desired time due to the lack of adhesion. In addition, since the teeth whitening strip has adhesion by Carbopol gel, which is an adhesive polymer inherent in the teeth, the adhesion to teeth or gums is not different. However, it may be desirable to have a special shape, such as folding it to the back of the tooth, without covering the tip of the canine, as strong adhesion is lacking and can be degraded by various stimuli. That is, in order to prevent detachment from the teeth, it is more preferable to fold and attach to the back of the teeth than to cover only the front part of the teeth.

On the other hand, in the dry type, since the feature is hydration and has a strong adhesive force, rather than the relatively dry tooth surface, the wet gum can be hydrated first and have a strong adhesive force. Because it can be more stimulating in some people. Therefore, in the form of a dry type tooth whitening patch, it is desirable to minimize the contact area of the gums. However, as mentioned earlier, since the pigmentation of the root part of the tooth, which is a part in contact with the gum, is relatively severe and is not easily whitened, this part is more preferably covered. It is also possible to have a fold line to cover the back of the tooth, but the lower teeth make contact with the tongue, so fewer folds are more comfortable. That is, in the case of lower teeth, the height is 2 to 4 cm, rather than covering both the front and the entire tooth, 0.3 to 2 cm, preferably 0.5 to 1.5 cm, the front part of the tooth is completely covered but the back part is partially covered or It is preferable not to cover or at all. In the case of upper teeth as well, it is more comfortable and comfortable to fold or partially cover the patch on the back of the tooth. Therefore, the upper teeth have a height of 0.5 to 2.5 cm, preferably 0.7 to 1.5 cm, and more preferably, the front part of the tooth is completely covered but the back part is partially covered or not covered at all.

The size of the tooth whitening patch may vary depending on the number of teeth to be white and the size of the teeth. In other words, from one tooth to the upper teeth, upper teeth, lower teeth may be applied to the entire lower teeth. When only one tooth is applied, the color of the part is not preferable because it is difficult to harmonize with the surrounding color, and in the entire application, it is inconvenient to make the mouth wide open and attach when attaching at one time. Therefore, it is desirable to cover the size of six to eight teeth that are seen when laughing or talking.

The shape of the tooth whitening patch can be a rectangle of the same height as a whole, but in this case, if the height is set to the maximum size of the tooth, the smaller teeth will have more gum contact area, and the overall height will be the average tooth size. When fitted, large teeth can cause the roots of the teeth (the areas where they come in contact with the gums) not to be sufficiently covered.

Human teeth are different in the size and shape of the upper teeth and lower teeth, because the bending is different, it is preferable that the teeth whitening patch also different size and shape for the upper teeth and lower teeth. For example, the upper teeth are usually the two largest teeth (the maxillary left and right incisors) and the largest rise from the gum, so it is desirable to make the tooth whitening patch the highest in height (convex). On the other hand, the lower teeth are the most protruding from the gum to the bottom of the canine so that the height of the canine portion is preferably the highest. In the case of Asian people, the height of the upper teeth is about 1 cm on average, although it is somewhat different depending on the person. In this case, the maximum height of the patch is preferably 0.8 to 1.5 cm. On the contrary, when the lower teeth have an average height of 0.9 cm, the maximum height of the patch is preferably about 0.6 to 1.5 cm.

In view of the above, in the present invention, the dry type is characterized in that the adhesion to the user's teeth is excellent and does not fall off the teeth unless they are deliberately removed by hand at the desired time, minimizing the irritation of the gums and at the same time whitening them. To achieve the effect, it is intended to provide a tooth whitening patch having a shape that takes into account the curvature of the upper and lower teeth.

The biggest advantage of the dry type in tooth whitening patches is that it has a strong adhesion after hydration, so that it can stick to the teeth for a sufficient amount of time even when there is no fold back. In addition, the fact that there is little foreign body feeling, and the part which touches the gum is minimized, also excellent in terms of irritation and safety can also be the best advantage. Also, even when the upper teeth and the lower teeth are attached at the same time, the upper teeth and the lower teeth are not in contact at all, so the convenience of use is also excellent. However, for lower teeth, dilution occurs by saliva, although less than when it is a wet type, it may not be attached for the desired time if a long time of attachment is desired. In this case, since the lower teeth in the folding type is a form that wraps the teeth like a forceps from above, there is an advantage that the dilution is less caused by the saliva, and thus can be sufficiently adhered for a desired time.

In order to maximize the effect of the tooth whitening product, it is desirable to lengthen the contact time between the whitening component and the tooth coloring component, which is used during bedtime for overnight use. It is for this reason that the first Dentist-Prescribed at-Home Bleaching product is used for sleeping using a custom tray. However, wet type products are not suitable for bedtime because of poor tooth adhesion. On the other hand, dry type products have excellent tooth adhesion, so bedtime usage is also possible. In this case, if it is a folding type, adhesive force can be heightened further and it is preferable.

The teeth whitening effect is increased in the sealed environment (sealed environment), so in the case of folding dry type can be expected to increase the whitening effect by providing such an environment.

In this type of dry type products, there is a way to increase the number of cuts in the folded parts by increasing the adhesive force, or adhesion, while minimizing foreign matters. In the case of the lower teeth, it minimizes the overlapping parts on the back of the teeth. When the lower teeth are folded, the feeling of foreign body is large and frustrating. The reason why the awl covers the back is relatively narrow, but the part that is folded back from the tooth after the canine is widened. Therefore, in the case of lower teeth, it is desirable to cover only the augers as much as possible.

Putting a notch in the middle, whether it is for upper teeth or lower teeth, is preferable because it can give convenience to use when the product is attached to a tooth. Once attached, there is an advantage in that the center line can be exactly aligned, especially in the case of the upper groove in the upper teeth, it is desirable to reduce the irritation because the product is less contact with the gum.

Examples of tooth whitening patches of the preferred form according to the invention are shown in FIGS. 2A and 2B to 6A and 6B.

Figures 2a and 2b is a plan view of the upper teeth and lower teeth for the tooth whitening patch according to an embodiment of the present invention, Figure 2a is the upper teeth when viewed from the gums for the upper teeth two (mid incisors) height 2b is a plan view of the height of the canine which protrudes downward when viewed from the gum for the lower teeth.

Figure 3a and Figure 3b is a plan view of the upper teeth and lower teeth for the tooth whitening patch according to another embodiment of the present invention, Figure 3a is the upper teeth when viewed from the gums for the upper teeth two teeth (medium incisors) A plan view of a notch in the center of the gum contact surface to increase the height and to make it easier to align the center part when attaching, and FIG. 3B shows the height of the canine that protrudes downward when viewed from the gum for the lower teeth. This is a plan view of the groove in the center of the gum contact surface to make it easy to fit the center when attaching.

Figures 4a and 4b is a plan view of the upper teeth and lower teeth for the tooth whitening patch according to another embodiment of the present invention, Figure 4a is the height of the middle teeth protruding from the top when viewed as gums for the upper teeth 4 is a plan view of the shape that can cover up to the back of the tooth, while raising the height of the canine which protrudes downward when viewed from the gum for the lower teeth, while increasing the height. to be.

Figures 5a and 5b is a plan view of the upper teeth and lower teeth for the tooth whitening patch according to another embodiment of the present invention, Figure 5a is the upper teeth when viewed from the gums for the upper teeth two teeth (mid incisors) height Insert a groove into the center of the gum contact surface to make it easy to align the center, and cover the back of the tooth, and cut the cut and / or groove in the fold for convenience when folding it back. Figure 5b is a plan view of the insert, Figure 5b is for the lower teeth, the height of the fangs protruding the lowest when viewed from the gums, while the groove in the center of the gum contact surface to cover the back of the teeth can be covered to facilitate the center This is a plan view of a cut line and / or a groove in the foldable portion for convenience when folding in the back while being in the form of being.

Figure 6a and 6b is a plan view of the upper teeth and lower teeth for the tooth whitening patch according to another embodiment of the present invention, Figure 6a is the upper teeth when viewed from the gums for the upper teeth two teeth (mid incisors) height Insert a groove into the center of the gum contact surface to make it easy to align the center, and cover the back of the tooth, and cut the cut and / or groove in the fold for convenience when folding it back. 6B is a plan view of one side incidence widened, and FIG. 6B shows a groove in the center of the gum contact surface to increase the height of the canine that protrudes from the lowermost when viewed from the gum for the lower teeth, and to facilitate the centering. Formed to cover the back of the teeth, cutouts and / or grooves in the folds for ease of folding back A plan view of things was as wide as the lateral incisor one size.

The form of the tooth whitening patch according to the present invention is not limited to that disclosed in the drawings mentioned above. Especially in the case of upper teeth, the middle part of the tooth structure can reach the gum most often.In this case, if the groove that is inserted to mark the center is inserted deeply, for example, twice the lower tooth groove, the area that touches the gum is further reduced. Can be used. In addition, the lower teeth have a large bend of the teeth, so if the folds are too narrow, if the thickness of the product is a little thick, they will overlap each other at the back of the teeth, which may make you feel uncomfortable and uncomfortable. It may be more preferable.

In order to obtain a dry type tooth whitening patch formulation according to the present invention, these hydrophilic glassy polymers are moistened by using hydrophilic glassy polymer as the main polymer of the layer except the supporter layer such as the adhesive layer or the drug layer. When hydrated to the enamel layer of the tooth in the oral cavity, it is required to have a strong adhesive force and at the same time release the tooth whitening agent.

In the case of tooth whitening patches, where the whitening effect can be achieved by simply attaching to the teeth without using a tray (non-tray type), when the adhesive layer is wet or gel type, the patch is removed from the release layer. In addition to the large amount of drug or adhesive components (80% or more) left on the hand during adhesion to the teeth by hand, the adhesive layer remains even when accidentally touches the face or lips. There is a lot of potential for unwanted results. In particular, teeth whitening agents use this peroxide because the use of a high weight ratio of peroxide, which is most effective in bleaching. On the other hand, when the dry type patch of the present invention is not hydrated, the drug or adhesive component is in light contact with the skin in a solid (sheet or film), and the drug or adhesive component remains within 0 to 10% when desorbed, which is more safe and convenient. It is characteristic.

In addition, in the case of a non-tray tooth whitening patch or adhesive, aptachi (mucoadhesive), a mucoadhesive used for the treatment of stomatitis, is a domestic anabolic drug and a Japanese manufacturer is TEIJIN or Taisho-A ( Salesman: Japanese pharmaceuticals, manufacturer: Japan TEIYAKU) In addition to the physical properties required in the moist oral cavity to achieve the desired effect, the adhesion to the desired area for the required time, as well as injustice In other words, even when you suddenly cough or make a loud sound when worn, the adhesive strength is required to not fall off. However, it is more difficult to control the adhesive force on the skin until it is detached by hand from the release layer and attached to the teeth, so it is more difficult to control the adhesive force.

This object can be easily achieved through the present invention, since the dry type patch of the present invention has a property of being hardly or weakly hydrated while being hydrated, and thus having strong adhesive force. In the case of the patch of the present invention, the strong adhesive strength when hydrated in most cases is also suitable for peeling off by hand, but if the adhesive strength is too strong according to the properties of the glass polymer used (mouthwash, gargle, water or drink) It can be used more conveniently because the adhesive strength is easily dropped.

In the tooth whitening patch, the backing layer is a sheet using a water-insoluble and water-impermeable polymer as a film former. It prevents the shape of the patch from being deformed or detached by saliva without sticking to the tongue.

On the other hand, the time-lapse stability of the peroxide used as a tooth whitening agent in the dry type tooth whitening patch may be a problem, in the present invention, to solve this problem by adding a peroxide stabilizer, or a glass polymer excellent in compatibility with the peroxide By appropriately adjusting the proportion of the solvent, the stability problem of the peroxide could be solved without adding a peroxide stabilizer. Accordingly, the present invention uses a hydrophilic glass polymer as a base material for the adhesion layer of a dry type patch using a peroxide as a tooth whitening agent, and uses a peroxide stabilizer to ensure the stability of the peroxide, or a good compatibility with the peroxide. The glass polymer is selected to provide a new type of patch that provides adequate stability of the peroxide by appropriately adjusting the solvent ratio.

In addition, in the patch for tooth whitening of the present invention, condensed phosphate (polyphosphates) may be used together with a peroxide as a tooth whitening agent to enhance the whitening effect.

The tooth whitening effect of the tooth whitening patch of the present invention can be controlled by adjusting the thickness or drug of the patch, which becomes transparent as it is hydrated when worn, and does not have a pattern or a pocket on the backing layer so that it adheres to the teeth. While the oxygen droplets of the peroxide are observed, the user can perceive the whitening effect emotionally. In addition, because the ticket does not appear during wearing does not interfere with everyday life.

The tooth whitening patch of the present invention is a matrix type patch, which is attached to the enamel layer of the tooth rather than to the skin or mucous membrane, and supplies the whitening agent to the tooth surface for a sufficient time. The principle of the patch of the present invention attached to the tooth and the whitening agent in the matrix to release to the surface of the tooth is as follows: Among the methods used for transdermal delivery with time lag in the field of pharmacology, An example of a transdermal formulation that causes a drug to be released after a certain time after attachment is the idea of using moisture emanating from the skin. In other words, the drug permeability barrier (barrier) is installed between the skin adhesion surface and the drug reservoir and the agent is attached, and the barrier is hydrated by moisture invading the skin, thereby increasing the permeability of the drug over time. . At this time, the barrier material is a hydrophilic glassy polymer. In the present invention, by using a hydrophilic glass polymer in various layers of the matrix type patch, the whitening agent is not released when stored or when touched by hand for attachment to the teeth, but begins to be hydrated by moisture on the surface of the tooth. Adhesion and whitening agent release. As such, the use of a hydrophilic glass polymer for several layers other than the support layer of a dry type patch is one of the features of the present invention.

Glass polymers mainly used for the adhesive layer of matrix type patches for this purpose include polyalkylvinyl ether-maleic acid copolymers (PVM / MA copolymer, Gantrez AN 119, AN 139, S-97), polyvinyl alcohol, poly Acrylic acid, Poloxamer 407 (Pluronic), polyvinyl pyrrolidone-vinyl acetate copolymer (PVP / VA copolymer; Luviskol VA, Plasdone S PVP / VA), polyvinyl pyrrolidone (PVP, K-15-K-120 ), Polyquaternium-11 (Gafquat 755N), Polyquaternium-39 (Merquat plus 3330), Carbomer (Carbopol), hydroxypropylmethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, gelatin, alginate (sodium alginate) Either alone or mixtures thereof may be used. As these solvents, mainly water, ethanol, or these mixing ratios can be adjusted and used.

Teeth whitening patches should be flexible enough because they attach directly to the teeth and can be easily shaped as the teeth are bent. Since some of these polymers are inferior in flexibility, it is necessary to add an appropriate plasticizer. Suitable plasticizers vary depending on the type of polymer and its formulation, but may be used in general, polypropylene glycol, glycerin, or polyethylene glycol.

In the tooth whitening patch of the present invention, the tooth whitening agent contained in the tooth enamel adhesion layer is hydrogen peroxide, carbamide peroxide, calcium peroxide, sodium percarbonate, sodium perborate perborate), tetrasodium pyrophosphate peroxidate or mixtures thereof. Sodium pyrophosphate (TSPP-H ₂ O ₂ ), an addition compound of sodium pyrophosphate and hydrogen peroxide, exhibits the properties of hydrogen peroxide in aqueous solution or crystal state and at the same time exhibits the properties of sodium pyrophosphate itself. Normally, sodium pyrophosphate stabilizes hydrogen peroxide without altering its original properties and prevents the drawbacks of using hydrogen peroxide alone. In other words, hydrogen peroxide is accelerated by metal catalysts, ultraviolet rays, oxidases, heat treatments, etc., but sodium pyrophosphate is stable against all of these and exhibits the inherent properties and properties of hydrogen peroxide. In fact, sodium pyrophosphate showed better peroxide stability at 40 ° C than when only peroxides were used in liquids, gels, and pastes. However, peroxide stability in the patch was not easily obtained even by using sodium pyrophosphate as a whitening agent.

In general, peroxides are difficult to stabilize in a product due to their excellent reactivity, but are not particularly compatible with polymers. The stabilization of such peroxides in the product is also related to the shape and prescription of the product. In general, gels or pastes and solution phases have relatively many peroxide stabilization patents, and partially at a high temperature. It is known that the stability can be secured, but peroxide stabilization in thinly applied gels or patches is not known, and according to the results of the present inventors, it was not a problem that can be easily solved with generally known peroxide stabilizers. .

In view of this, the present inventors, while screening the stabilizer of the peroxide in the patch, the inventors found a stabilizer that can be used in the basic properties of the patch or the scope of use of the present invention at a high temperature of the peroxide in the patch as in the present invention Over time stability can be significantly improved. Accordingly, it is one of the features of the present invention to use a peroxide which is a tooth whitening agent together with a peroxide stabilizer.

Stabilizers that are compatible with peroxides in tooth whitening patches of the present invention include alkylaryl sulfonates, alkyl sulfonate salts, alkyl carboxylate salts, alkyldiphenyloxide disulfonates, span 20 (Span 20, Sorbitan Monolaurate), Span 40 (Sorbitan Monopalmitate), Span 60 (Span 60, Sorbitan Monostearate), Span 80 (Span 80, Sorbitan Monooleate), Span 85 (Span 85, Sorbitan Trioleate), TWEEN (POE sorbitan fatty acid ester) Mixtures of these can be used. The peroxide stabilizer will be described in more detail below.

In the teeth whitening patch to use a peroxide as a main tooth whitening agent, when the created a patch only such a whitening agent is, even when stored at 40 ℃ to decline over this patch within a peroxide content hours in vitro whitening effect of the present invention first More falling was confirmed. In the case of gel formulations, the peroxide loss was very low without a separate stabilizer even when the polymer was used as a film-forming agent in a formulation containing the same peroxide as the adhesive. First, a desired level of prescription can be obtained by adding a small amount of EDTA or sodium citrate, for example. However, as in the present invention, in the sheet-type patch obtained by evaporating the solvent of the gel, even if the same prescription is used, the stability of peroxide is lower than that of the solution, even if the stabilizer is not added. When the chelating agent was added, it was confirmed that the stability of the peroxide in the patch was lower than before the addition. Moreover, even when added to the patch, Dequest phosphonates known to have excellent peroxide stabilizing effects could not be obtained.

There are various reasons why the peroxide over time stability in prescription depends on whether the same composition is gel, liquid, or sheet. However, according to US Pat. No. 4,320,102, a very small amount of metal can be catalyzed by a metal reaction. It is said to be very sensitive to decomposition even in prescription. In other words, hydrogen peroxide decomposes even if only 0.1 mg of iron, 0.2 mg of copper, 0.1 mg of magnesium, and 0.02 mg of chromium per liter. Based on these data, sheet-like patches made by evaporation of solvent in solution or gel state have relatively high contents because they contain high content of metal in thin thickness and increase reactivity due to wide surface area. It is thought that stability with time of a peroxide will become inadequate.

In the present invention, materials used as peroxide stabilizers in patches are mainly surfactants or emulsifiers, which form micelles on sheets to prevent contact between raw materials and incompatible materials with poor peroxides, or glass polymers with poor applicability. When used, it is thought that the whitening agent is uniformly dispersed throughout the patch and the adhesive layer is uniformly applied to positively affect the peroxide stabilization. Indeed, the gels in the container had excellent stability over time at relatively high temperatures, while the same gel formulations were applied to the strips to increase the surface area, and when evaluated over time, the residual peroxide ratio decreased significantly over time. . However, the present inventors have found that some of the hydrophilic glassy polymers are excellent in compatibility with the peroxides and can be sufficiently stabilized by appropriately adjusting the proportion of the solvent without adding a peroxide stabilizer. Accordingly, the scope of the present invention is not limited to using only peroxide and peroxide stabilizer together. This will be described in more detail below.

Polyvinyl pyrrolidone (PVP, K-15 to K-120), Polyquaternium-11, Polyquaternium-39, polyvinyl pyrrolidone-vinyl acetate copolymer (PVP / VA copolymer) among hydrophilic glassy polymers Was not only soluble in both water and ethanol, but also had excellent compatibility with peroxides. When the water and ethanol ratios were adjusted to 9: 1 to 0:10 without the addition of peroxide stabilizers, the stability of peroxide in the patch was excellent. . Such good compatibility of peroxide and polyvinyl pyrrolidone is thought to be due to the formation of a complex by hydrogen bonding of polyvinyl pyrrolidone and peroxide to stabilize. Among them, polyvinyl pyrrolidone is the most preferred hydrophilic glass polymer for use as a main polymer for drug layers containing peroxides. Such good compatibility between peroxide and polyvinyl pyrrolidone is thought to be due to the formation of a complex by hydrogen bonding of polyvinyl pyrrolidone and peroxide to stabilize. Although PVP can use all K-15 to K-120, PVP (K-90) was preferable in this invention. However, in the case of producing by casting (casting), the higher the polymer content in the gel in terms of production efficiency in the manufacturing process is preferable, PVP (K-30) is more preferable. PVP preferably has a relatively high molecular weight of at least 500,000 molecular weight, more preferably at least 1,000,000 molecular weight. Most preferably PVP with a molecular weight of 1,270,000 is used. In addition, it was confirmed that the polymer and the peroxide having a quaternary ammonium structure such as Polyquaternium have good compatibility. The use of a mixed solvent of water and ethanol as a solvent means that the glass polymers having good compatibility with these peroxides are very hydrophilic and are not uniformly applied to a release layer or another sheet, but a mixed solvent of water and ethanol is used as a solvent. This is because this problem can be solved and a uniform sheet phase can be obtained. Therefore, in the tooth whitening patch of the present invention, when the glass polymer having high compatibility with the peroxide is used, the peroxide is used as the tooth whitening agent and the water and ethanol solvent ratios are controlled in the adhesive layer composition during preparation without the addition of a separate peroxide stabilizer. Another feature is that a patch having excellent peroxide stability at high temperatures can be produced. In this case, as in the patch containing the peroxide stabilizer, an appropriate plasticizer may be added depending on the polymer in order to give the patch sufficient flexibility. Suitable plasticizers are polypropylene glycol, glycerin, polyethylene glycol, and the like, which may be used depending on the type of polymer and the prescription thereof.

In addition, although the tooth whitening patch of the present invention uses a peroxide as a main whitening agent, condensed phosphates (polyphosphates) may be used together with the peroxide to improve the whitening effect. Condensed phosphates that can be used are, for example, sodium pyrophosphate (TSPP), sodium pyrophosphate (SAPP), sodium hexametaphosphate (SHMP) and sodium tripolyphosphate (STP). , Among sodium potassium tripolyphosphate (SKTP), potassium pyrophosphate (TKPP), acidic sodium meta-polyphosphate (Sporix), ultraphosphate (acidic sodium polyphosphate, Multiphos) Species or more may be used with the peroxide. In general, condensed phosphate is known to be effective as a tartar control agent in toothpaste to inhibit tartar formation or to remove tartar. In addition, they are good chelating agents of metals, which can effectively remove tooth pigmentation produced by metals such as iron, calcium and magnesium in food or working environment during tooth staining, which may contribute to the improvement of whitening effect. It is known. Therefore, when the polyphosphate is used in combination with the peroxide in the tooth whitening patch of the present invention, it is expected that not only the improvement of the whitening effect but also the contact time between the tooth and the polyphosphate may be effective in suppressing tartar formation or removing tartar. In fact, it can be seen that the surface of the teeth or between the teeth is clean when the patch containing them is attached.

Polymers usable for the backing layer of the matrix patch according to the invention are polyvinyl acetate, ethyl cellulose, polymethyl methacrylate, methacrylic acid copolymers, for example methacryloyl ethyl betaine / Methacrylate copolymer (Yukaformer: Mitsubishi, Metacryloyl Ethyl Betain / Metacylate Copolymer), Methacrylic acid copolymers; Eudragit L 100, Eudragit L 12, 5, Eudragit L 100-55, Eudragit L 30D-55 ), Aminoalkyl methacrylate copolymers (Eudragit E 100, Eudragit E 12, 5, Eudragit RL 100, Eudragit RL 30D), cellulose acetate phthalate, Shellac alone or mixtures thereof. In addition, it is an enteric coating material that can be used as long as the polymer does not dissolve in oral conditions between pH 6 and 8.

In the tooth whitening patch of the present invention, the supporter layer may be used by adding various plasticizers in order to have sufficient flexibility. In addition to the above-mentioned plasticizers propylene glycol, glycerin and polyethylene glycol, more plasticizers can be used depending on the solvent used, and caster oil and hydrogenated caster oil can also be used.

In addition, the tooth whitening patch of the present invention is not only whitening by chemical and physical action when attached to the teeth but also a white pigment titanium dioxide, talc (white pigment) in the support layer so that it may appear visually white. talc), hydroxyapatite, zinc oxide and the like can be used in combination. If these pigments are not compatible with the whitening agent of the adhesive layer, surface-treated titanium dioxide can be used. In addition to the white pigment, it is also possible to apply a pearl or a pigment of various colors depending on the individuality.

Dry type tooth whitening patch formulation according to the present invention may be used alone or in combination with enzymes, particularly dextranase, glucose oxidase, etc., which are difficult to apply over time in toothpaste, papain (papain) that is effective in whitening teeth Etc. can also be added. Therapeutic medicinal products for oral disease include triclosan, chlorhexidin, vitamin E or derivatives thereof, especially vitamin E acetate, or oxidants, chlorophyll or derivatives thereof, and flavors effective for removing bad breath. It is possible.

The method of using a dry type tooth whitening patch according to the present invention consists of attaching to a surface of a tooth to be whitened. Patches are largely divided into water-soluble parts and water-insoluble parts (support layer). The water-soluble part directly contacts the surface of the tooth, and the support layer serves as a protective wall. Dry type tooth whitening patches increase hydration and increase adhesion as they are hydrated. However, it can be fully hydrated with minimal moisture, so it doesn't matter unless you deliberately wipe and dry the tooth surface. In addition, since excessive adhesion of the hydrophilic glass polymer melts suddenly and the adhesive force drops rapidly, it is not preferable to consume excessive water or drink while the tooth whitening patch is attached to the teeth.

As an example of a specific method of use, once the center of the patch is aligned with the center of the teeth to be attached, it is positioned by hand and then pressed to close contact. It is preferable to push with a hand or a tongue to close the gap between teeth. .

The tooth whitening patch according to the present invention can be easily detached due to its low adhesive force if it is attached at a time of about 30 minutes or 1 hour. However, in some cases, the adhesive force does not drop even after elapse of time. In this case, if you attach it more and then detach it at the time of dropping, there is no problem with safety, but it can help the whitening effect. If you just want to remove it quickly, you can easily rinse it off with water.

Such a whitening adhesive for teeth whitening is effective in achieving a whitening effect in a short period of time because it sufficiently secures contact between the peroxide and the teeth stain, but unlike the toothpaste, since the refreshing part is weak, the patch is removed according to the preference. You can also brush your teeth afterwards. However, brushing teeth before patching is not recommended because it can cause irritation without much help for whitening.

Hereinafter, a preferred embodiment of the present invention. However, these examples are only illustrative to aid the understanding of the present invention, and the scope of the present invention is not limited thereto.

Examples 1 to 5, Comparative Example 1

Tooth whitening patches of Examples 1 to 5 and Comparative Example 1 were prepared according to the compositions described below.

Example 1

Drug-containing adhesive layer preparation solution

Water was added to 10% polyvinyl alcohol, 10% polyvinylpyrrolidone, 5% sodium pyrophosphate, 5% alkylaryl sulfonate (SLS) and 3% glycerin to make 100%.

Support layer preparation solution

Ethanol was added to 8% ethyl cellulose, 5% Eudragit, and 4% castor oil to make 100%.

Example 2

Adhesive layer manufacturing solution

Ethanol was added to 30% of hydroxypropyl cellulose to obtain 100%.

Drug layer preparation solution

Water was added to 20% polyvinylpyrrolidone, 5% hydrogen peroxide, 10% glycerin and 30% ethanol to make 100%.

Support layer preparation solution

Ethanol was added to 5% polyvinyl acetate, 5% Yukaformer (Mitsubishi) and 6% glycerin to make 100%.

Example 3

Drug-containing adhesive layer preparation solution

Water was added to 10% of Polyquaternium-39, 10% of urea peroxide, and 50% of ethanol to make 100%.

Support layer preparation solution

30% cellulose acetate phthalate and 4% castor oil were added to acetone: ethanol = 4: 1 mixed solution to make 100%.

Example 4

Adhesive layer manufacturing solution

Ethanol was added to 20% of polyvinylpyrrolidone to make 100%.

Drug layer preparation solution

Water was added to 12% of polyalkylvinyl ether-maleic acid copolymer (Gantrez S 97), 6% of sodium pyrophosphate and 0.5% of sorbitan oleate to make 100%.

Support layer preparation solution

Ethanol was added to 10% ethyl cellulose and 6% castor oil to make 100%.

Example 5

Adhesive layer manufacturing solution

Water was added to 10% polyvinyl alcohol, 10% polyvinylpyrrolidone and 3% glycerin to make 100%.

Drug layer preparation solution

Water was added to 20% of Polyquaternium-11, 4% of PC, 4% of TKPP and 2% of sorbitan monolaurate to 100%.

Support layer preparation solution

Ethanol was added to 15% of Eudragit and 5% of propylene glycol to make 100%.

Comparative Example 1

Drug-containing adhesive layer gel

Water was added to Carbopol 12%, 4.5% hydrogen peroxide, 0.48% SAPP and 80% glycerin to 100%.

Support layer

Polyethylene strips.

TKPP in the above examples; tetrapotassium pyrophosphate, SAPP; sodium acid pyrophosphate, TSPP; tetrasodium pyrophosphate

Experimental Example 1

Gum irritation evaluation

1a, 2a, 3a, 4a, 5a, and 6a in Table 1 are all for upper teeth, and the prescription is the same dry type as in Example 1, but only in form. Figure 2a is a non-folded form, Figure 4a is a folded form but no cut, Figures 5a and 6a is a folded form and cut. 1A is for P & G's Crest Whitesptrip upper teeth currently sold in the United States. 1A is the prescription of the comparative example 1, and the form is a thing folded into a form as shown in a figure.

As described above, all other conditions were the same, and only various types of patches were used, and each was worn twice a day for 30 minutes or more for 2 weeks, and then gum stimulation and wearing comfort were evaluated. The adhesion sustainability was also evaluated, and how well the adhesion was maintained even when applied for more than 1 hour in the usage for 30 minutes or more. Each rating is on a 5-point scale, very satisfied 5 points (no irritation, very strong tooth adhesion, very good adhesion lasting), slightly satisfied 4 points (almost no stimulation, slightly stronger tooth adhesion, slightly better adhesion lasting), moderate 3 points (sometimes irritation, moderate adhesion, moderate adhesion), slightly dissatisfied 2 points (irritation at initial use, slightly weaker adhesion, slightly less sustained adhesion), very unsatisfactory 1 point (continuous stimulation during use, very weak adhesion) Adhesion is very poor).

The lengths of FIGS. 1A, 2A, 3A, 4A, 5A, and 6A were all similar to could cover 6-8 teeth, and were evaluated by 10 for each case. Table 1 shows the results of usability and safety evaluation for each type.

Gum irritation Wear comfort Tooth adhesion Adhesion lasting  Figure 2a 4.5 4 5 3  3a 4 3 4 5  4a 4 4 4 5  Figure 5a 4 4 4 5  6a 4 4 4 5  Figure 1a 3 3 3 2

2A, 3A, 4A, 5A, and 6A, the formulations of Fig. 2A that do not fold even in the same dry type of Example 1 have the best gum irritation, that is, the least irritation. Can be. On the other hand, the adhesion sustaining force was better in those of Figs. 3a, 4a, 5a and 6a, which is a folding type even in the same dry type. Therefore, in the case of the usage used for a long time more than 30 minutes, even if it is the same dry type, it is judged that the folding type is more preferable. As a result, even though the length is similar, there is a difference in gum irritation, wearing comfort, tooth adhesion and adhesion persistence, depending on whether it is a dry type or a wet type. Able to know.

Experimental Example 2

Next, unlike Table 1, the adhesion to the teeth of the tooth whitening patch was measured by a mechanical method.

(1) Preparation of Hydroxyapatite (HAP) Tablet Specimen

The hydroxyapatite powder was tableted by IR press and then sintered at 1000 ° C.

(2) tooth adhesion evaluation

A miniature tensile tester was used to measure the adhesion of the patch to hydroxyapatite, an artificial tooth, and the results are shown in Table 2. Adhesion in the dry state is a measure of the adhesion of the sintered hydroxyapatite specimen in a completely dry state, the adhesion in the wet state is to wet the specimen sufficiently in advance by water, and then remove the moisture on the surface It is measured. The reason for this definition of wetting conditions is that the mouth is actually wet, but the surface of the tooth is not so large that it appears to be moist. Adhesion of the patch to the teeth was repeatedly measured several times after a certain time, after a certain time, the force applied when the patch was pressed for a certain time with a constant force and then detached. Table 2 shows tooth adhesion (gmf).

Dry adhesion Wet adhesion Example 1 0.8 205.9 Example 2 24.3 85.75 Example 3 40.0 105.5 Example 4 17.0 160.2 Example 5 22.1 114.0 Comparative Example 1 38.0 39.5

As shown in Table 2, in Examples 1 to 5, which are dry type patches, the difference in adhesion between the dry state and the wet state increases by 2 to as much as 260 times, while the wet type, in particular, gel In the case of Comparative Example 1 coated with a strip, it can be seen that there is almost no difference in the adhesive force in the dry state or the wet state.

As described above, the tooth whitening patch according to the present invention is a dry type using a hydrophilic glassy polymer (glassy polymer) in the layer except for the support layer, so that the adhesive force and the release of the whitening agent are started while being hydrated upon contact with the tooth. It is safer to use and it is convenient to use because it doesn't get in contact with hands or other body parts, and it has excellent adhesion, so it doesn't detach during wearing, but it adheres perfectly to the surface of teeth, so it has excellent whitening effect and minimizes contact with gums. It has a form that completely covers the entire part of, so it has low irritation and good fit.

1A and 1B are plan views showing upper and lower teeth forms of C & C's Crest Whitestrip, respectively.

Figures 2a and 2b is a plan view of the upper teeth and lower teeth for the tooth whitening patch according to an embodiment of the present invention, Figure 2a is the upper teeth when viewed from the gums for the upper teeth two (mid incisors) height Figure 2b is a plan view of the heightened, Figure 2b is a plan view of the height of the canine protrudes to the bottom when viewed from the gum for lower teeth.

Figure 3a and Figure 3b is a plan view of the upper teeth and lower teeth for the tooth whitening patch according to another embodiment of the present invention, Figure 3a is the upper teeth when viewed from the gums for the upper teeth two teeth (medium incisors) A plan view of a notch in the center of the gum contact surface to increase the height and to make it easier to align the center part when attaching, and FIG. 3B shows the height of the canine that protrudes downward when viewed from the gum for the lower teeth. Top view of the groove in the center of the gum contact surface to make it easier to align the center when attaching.

Figures 4a and 4b is a plan view of the upper teeth and lower teeth for the tooth whitening patch according to another embodiment of the present invention, Figure 4a is the height of the middle teeth protruding from the top when viewed as gums for the upper teeth 4 is a plan view of the shape that can cover up to the back of the tooth, while raising the height of the canine which protrudes downward when viewed from the gum for the lower teeth, while increasing the height. .

Figures 5a and 5b is a plan view of the upper teeth and lower teeth for the tooth whitening patch according to another embodiment of the present invention, Figure 5a is the upper teeth when viewed from the gums for the upper teeth two teeth (mid incisors) height Insert a groove into the center of the gum contact surface to make it easy to align the center, and cover the back of the tooth, and cut the cut and / or groove in the fold for convenience when folding it back. Figure 5b is a plan view of the insert, Figure 5b is for the lower teeth, the height of the fangs protruding the lowest when viewed from the gums, while the groove in the center of the gum contact surface to cover the back of the teeth can be covered to facilitate the center Top view of cutouts and / or grooves in the folds for ease of folding in the back, while keeping the shape in place.

Figure 6a and 6b is a plan view of the upper teeth and lower teeth for the tooth whitening patch according to another embodiment of the present invention, Figure 6a is the upper teeth when viewed from the gums for the upper teeth two teeth (mid incisors) height Insert a groove into the center of the gum contact surface to make it easy to align the center, and cover the back of the tooth, and cut the cut and / or groove in the fold for convenience when folding it back. 6B is a plan view of one side incidence widened, and FIG. 6B shows a groove in the center of the gum contact surface to increase the height of the canine that protrudes from the lowermost when viewed from the gum for the lower teeth, and to facilitate the centering. Formed to cover the back of the teeth, cutouts and / or grooves in the folds for ease of folding back A plan view of things as wide as one incisor size.

Claims (12)

delete In the dry type tooth whitening patch, the upper teeth patch and the lower teeth patch are 0.5 to 2.5 cm in height, and the height of the middle part attached to the mid incisor (upper left and right middle incisors) is the highest. The lower tooth patch is a dry tooth whitening patch, characterized in that the height of both ends attached to the canine (mandible left and right canine) with a height of 0.3 to 2.0 cm. delete The method of claim 2, wherein the whitening agent is hydrogen peroxide, carbamide peroxide, calcium peroxide, sodium percarbonate, sodium perborate, tetrasodium pyrophosphate peroxidate) and mixtures thereof, and polyalkylvinyl ether-maleic acid copolymers (PVM / MA copolymer, Gantrez AN 119, AN 139, S-97), polyvinyl alcohol, polyacrylic acid, Poloxamer 407 (Pluronic), polyvinyl pyrrolidone-vinyl acetate copolymer (PVP / VA copolymer; Luviskol VA, Plasdone S PVP / VA), polyvinyl pyrrolidone (PVP, K-15 to K-120), Polyquaternium-11 (Gafquat 755N), Polyquaternium-39 (Merquat plus 3330), Carbomer (Carbopol), hydroxypropylmethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, gelatin, sodium alginate and mixtures thereofGlidden hydrophilic when the polymer (glassy polymer) of the vital tooth whitening patch dry-type which is characterized in that it comprises as being chosen. The method of claim 4 wherein the peroxide is alkylaryl sulfonate, alkyl sulfonate salt, alkyl carboxylate salt, alkyldiphenyloxide disulfonate, Span 20, Sorbitan Monolaurate, Span 40, Sorbitan Monopalmitate ), Span 60 (Sorbitan Monostearate), Span 80 (Span 80, Sorbitan Monooleate), Span 85 (Span 85, Sorbitan Trioleate), TWEEN (POE sorbitan fatty acid ester) system and mixtures thereof A dry type tooth whitening patch characterized by containing together with a topic. The dry type tooth whitening patch of claim 2, wherein the height of the patch is similar to the size of the tooth so that a portion of the patch does not need to be folded into the back of the tooth. The dry type tooth whitening patch of claim 2, wherein a portion of the patch is folded into the back of the tooth, and a cut line is easily inserted into the patch. delete The dry type tooth whitening patch according to claim 2, wherein the upper tooth patch has a height of 0.7 to 1.5 cm, and the highest portion has a height of 0.8 to 1.5 cm. 3. The dry tooth whitening patch of claim 2, wherein the lower tooth patch has a height of 0.5 to 1.5 cm, and the highest portion has a height of 0.6 to 1.5 cm. delete The dry type tooth whitening patch of claim 2, wherein the tooth whitening patch of the dry type has a notch in the center of the contact area with the gum so as to indicate the center of either the upper tooth patch or the lower tooth patch.