KR100455228B1 - Semi-transparent patches for teeth whitening - Google Patents

Abstract

The present invention relates to a dry type tooth whitening patch containing a peroxide as a tooth whitening agent. Specifically, the hydrophilic glassy polymer is moistened by using a hydrophilic glassy polymer in the matrix-type adhesive layer, which contains a peroxide as a whitening agent and a peroxide stabilizer, and a polymer that is used as a base. The dry type tooth whitening patch that produces strong adhesion when hydrated to the enamel layer on the tooth and releases the tooth whitening agent at the same time has excellent stability over time at high temperatures and the color of the patch is not transparent. It is a semi-transparent dry type tooth whitening patch that is inconspicuous when worn on teeth.

Description

Translucent tooth whitening patch {SEMI-TRANSPARENT PATCHES FOR TEETH WHITENING}

The present invention relates to a dry type patch that removes stains of teeth and makes teeth white by just attaching them to the teeth. Although it does not use a tray, it has sufficient adhesion to teeth, so it does not interfere with daily life after attachment, and it is more convenient to use because it is not easily separated from teeth even when coughing or making a loud sound. Although the formulation is not transparent, it is thin and flexible enough to be inconspicuous to other people when worn, the teeth look whiter while wearing, and do not interfere with speaking, so it is a translucent dry type tooth whitening patch that does not interfere with daily life.

With increasing interest in teeth whitening, many types of whitening toothpastes are on the market. However, even if the toothpaste contains an effective whitening agent, it is difficult to identify a significant whitening effect in a short time by brushing with a contact time of 1 to 3 minutes. Recently, various formulations of whitening products and related patents have been issued to solve this problem. Most of these are formulations that contain high concentrations of peroxides as whitening agents and ensure contact time for sufficient reaction between teeth and whitening products.

Professional whitening products that use trays are to make trays that fit the size of the patient's teeth and apply a certain amount of high-peroxide gel directly. The whitening effect is known to be excellent, but it is expensive and can be applied to the gums due to the use of a relatively large amount of gel. It will interfere with your life. In addition, the effect can be seen quickly when wearing for a relatively long time, so it is recommended to use 6 to 8 hours overnight a day.

In order to solve this problem, many patents have been applied for non-tray teeth whitening products. Proctor & Gamble's Crest Whitestrip, the first of its type, is very convenient without the use of trays, but the adhesive layer's low adhesion makes it convenient to remove, but it can be used when coughing or laughing loudly. There was a problem falling from the teeth when speaking. In addition, the gel type is applied evenly on a thin strip, which is removed from the release liner, and when touched by hand, a large amount of adhesive layer remains on the hand, and inadvertently other parts of the body, such as arms or Similarly, a large amount of adhesive layer remains on the skin when it comes in contact with the face and lips, which is inconvenient, and the high concentration of peroxide used as a tooth whitening agent acts on unwanted areas, resulting in a drop in safety. In addition to the problem that the adhesive layer remains in an undesired place, the adhesive layer is pushed out of the release liner when it is carried in the pouch packaging and the adhesive layer is lost in the pouch, or a large amount is left in the release liner when the strip is removed from the release liner. There was a lot of problems such as breaking off. It also has a shallow pocket on the strip, making the product transparent but uneven, making it stand out from others.

In the present invention, in order to solve these problems, the formulation is selected as dry type, and the hydrophilic glassy polymer is selected as the main polymer of the adhesive layer. Invented a dry type tooth whitening patch that is sufficiently hydrated by saliva that is naturally buried on the inner surface of the tooth, resulting in adhesion and increased adhesion than in the dry state. In the dry state, the adhesive layer is not only low or low, but also solid, so there is no adhesive layer or only a small amount left on the unwanted areas such as hands and skin. At this time, the dry type patch made by the emulsifying power of the peroxide stabilizer used together for stabilization of peroxide is not transparent, but the greatest stability is that the peroxide in the product is excellent at high temperatures without noticeable or disturbing conversation when worn. It is characteristic.

The present invention is a patch that can provide a time for the tooth whitening agent to sufficiently contact the stain of the surface of the tooth. Peroxide is a whitening agent in patch with peroxide stabilizer to improve the stability of peroxide at high temperature. Peroxide content in patch is usually lower or lower than that applied to whitening toothpaste. This is a dry type using hydrophilic glassy polymer in the adhesive layer. When attaching to a tooth, the patch is detached from the release liner by hand. Even if you accidentally touch unwanted areas such as your face or lips, the adhesion layer does not adhere, and even though it contains a high concentration of peroxide as a whitening agent, the glassy polymer is hydrated by the moisture on the surface of your teeth, which is a strong adhesion and whitening agent. Is a safer formulation as it begins to release. Although thin enough and flexible, the patch color is transparent, but when worn, the teeth appear whiter and are inconspicuous to others so it is a convenient formulation for everyday life.

The present invention is a tooth whitening patch containing a peroxide, the whitening effect of the short-term use is very excellent, the feeling is good and convenient, it does not interfere with daily life is a patch for tooth whitening. To achieve this goal, the dry type was found to be more desirable and the peroxide stabilizer in the formulation was needed for stability over time at high temperatures. Specifically, the hydrophilic glass polymer is moistened by the use of a hydrophilic glassy polymer as a polymer, which contains a peroxide as a whitening agent and a peroxide stabilizer in a matrix-type adhesive layer. A new dry type tooth whitening patch that produces strong adhesion when hydrated to an enamel layer on a tooth in the oral cavity and at the same time releases a tooth whitening agent.

In the case of the tooth whitening patch which can be seen only by attaching to a non-tray type of tooth that does not use a tray, the adhesive layer is wet instead of the dry type, or the adhesive layer is a gel type, as in the present invention. In the process of removing the patch from the release liner and attaching it to the teeth by hand, a considerable amount of adhesive layer remains on the hand, and even if it accidentally touches the face or lips, the adhesive layer remains uncomfortable. There is a good chance that it will not result. In particular, most teeth whitening agents use this peroxide because they have a high weight ratio of peroxide with good bleaching effect. The dry type patch of the present invention is more preferred for such formulations as it does not remain in the skin before hydration.

In addition, in the case of non-tray tooth whitening patches or adhesives, in order to achieve the desired effect in a moist oral cavity, such as the mucoadhesive mucoadhesives used for the treatment of stomatitis or the properties required for Taisho-A Not only is it needed to adhere to the mucous membranes for the required time, but it is also necessary to ensure that the adhesive strength does not drop in case of injustice, such as a sudden cough or loud noise when worn. However, it is more desirable to have a low adhesion before attachment to the teeth because it is difficult to control if the adhesion to the skin is too good until it is detached by hand from the release liner. This object can be easily achieved through the dry type patch of the present invention. That is, the dry type patch of the present invention is hardly adhesive or weak until it is hydrated, and has a characteristic of generating strong adhesive force while being hydrated.

In order to make such dry type patches, a polymer is necessary in dry state that has no adhesive strength or weak strength, but is hydrated by a small amount of water in the area where the whitening agent is desired to be formed, or the adhesive force is formed and the whitening agent is released. Do. In the present invention, it was found that the hydrophilic glassy polymer (glassy polymer) has these properties, the hydrophilic glassy polymer (glassy polymer) was used as the main polymer in the adhesive layer (adhesive) to the patch of the matrix form.

Backing is a sheet using water-insoluble and water-impermeable polymer as film former. It prevents the patch from being deformed or detached by saliva without sticking to gums or tongue when attached to teeth.

As in the present invention, when the dry type is used, the stability over time of the peroxide used as the tooth whitening agent is a problem. In the present invention, this problem is solved by adding a peroxide stabilizer. In the case of selection, by controlling the ratio of the solvent appropriately, the stability problem of the peroxide could be solved without adding the peroxide stabilizer. Therefore, the present invention uses a hydrophilic glass polymer as a base material for the attachment layer of a dry type patch using a peroxide as a tooth whitening agent, and uses a peroxide stabilizer to secure the stability of the peroxide, or a glass polymer having good compatibility with the peroxide. By selecting the appropriately adjusted solvent ratio to provide a new type of patch that ensures the stability of the peroxide (stability).

In addition, in the present invention, in order to enhance the whitening effect, condensed phosphate (polyphosphates) may be used together with a peroxide as a tooth whitening agent.

The tooth whitening effect can be controlled by adjusting the thickness of the patch or the drug, and it becomes transparent as it is hydrated when worn and does not have a pattern or pocket on the backing. You can also notice the whitening effect. In addition, because the ticket does not appear while wearing it may not interfere with daily life.

The present invention is characterized by supplying a whitening agent for a sufficient time by attaching to the enamel layer of the tooth rather than attaching it to the skin or mucous membrane with a matrix type patch. In the present invention, the patch is attached to the tooth, the principle that can release the whitening agent in the matrix on the surface of the tooth is as follows. In the field of drug delivery, one of the methods used for transdermal delivery with time lag is an example of the use of water emanating from the skin as an example of a transdermal formulation that has been attached and allowed to release the drug after a certain time. In other words, the drug impermeable barrier (barrier) between the skin adhesion surface and the drug reservoir and the drug is attached after the drug is applied to the permeability of the barrier over time to increase the permeability of the drug over time will be. In this case, the barrier material is a hydrophilic glassy polymer. In the present invention, using a hydrophilic glass polymer on the adhesive layer of the patch of the Matrix Type using the technique, the whitening agent is not released when stored or when touched by hand for attachment to the teeth, but begins to hydrate by moisture on the surface of the tooth. While the adhesion and the release of the whitening agent is characterized in that it takes place. These glass polymers also have excellent adhesion to most hydrophilic tooth surfaces, so there is no need to fold the patch to the back of the tooth to ensure sufficient contact time. In addition, in case of gum, even a small amount of whitening agent is used, even if it is not a big irritation is concerned, it is also a big feature that the release of the whitening agent may not occur in the gum when attaching the patch to touch only the tooth if desired.

For this purpose, the glass polymers mainly used in the adhesive layer of Matrix Type patches are polyalkyl vinyl ether-maleic acid copolymers (PVM / MA copolymer, Gantrez AN 119, AN 139, S-97), polyvinyl alcohol, Polyacrylic acid, Poloxamer 407 (Pluronic), polyvinylpyrrolidone-vinylacetate copolymer (PVP / VA copolymer; Luviskol VA, Plasdone S PVP / VA), polyvinylpyrrolidone (PVP, K-15 to K-120 ), Polyquaternium-11 (Gafquat 755N), Polyquaternium-39 (Merquat plus 3330), Carbomer (Carbopol), hydroxypropylmethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, gelatin, sodium alginate It is possible to use alone or mixtures thereof. As these solvents, mainly water, ethanol and their mixing ratio may be adjusted.

Tooth enamel patches should be flexible enough because they attach directly to the teeth and must be easily shaped as the teeth are bent. Some polymers lack this flexibility, so a suitable plasticizer has been added. Suitable plasticizers vary depending on the type of polymer and its formulation, but are commonly used polypropylene glycol, glycerin and polyethylene glycol.

The tooth whitening agent contained in the tooth enamel adhesion layer is hydrogen peroxide, carbamide peroxide, calcium peroxide, sodium percarbonate, sodium perborate, and pyrophosphate Sodium (tetrasodium pyrophosphate peroxidate) and mixtures thereof were selected and used. Sodium pyrophosphate (TSPP-H2O2), an addition compound of sodium pyrophosphate and hydrogen peroxide, exhibits the properties of hydrogen peroxide in aqueous solution or crystalline state and at the same time exhibits the properties of sodium pyrophosphate itself. Normally, sodium pyrophosphate stabilizes without changing the nature of hydrogen peroxide. It also prevents the drawbacks of using hydrogen peroxide alone. Hydrogen peroxide is accelerated by metal catalysis, ultraviolet rays, oxidase, heat treatment, etc., but sodium peroxide pyrophosphate is stable against all these and exhibits the original properties and properties of hydrogen peroxide. In fact, sodium peroxide pyrophosphate had better stability over time at 40 ° C than when only peroxides were used in liquids, gels, and pastes. However, the peroxide stability in the patch was not easily obtained even by using sodium peroxide pyrophosphate as the whitening agent.

Generally, peroxides are difficult to stabilize in products due to their excellent reactivity, but are not particularly compatible with polymers. The stabilization of peroxide in the product is related to the form and prescription of the product, and there are many patents related to the peroxide stabilization in general gel, paste, and solution phases. Although it is known that peroxide stabilization in thinly applied gels or patches is not a known technique, the results of the inventors of the present invention were not a problem that can be easily solved with generally known peroxide stabilizers.

The inventors found a stabilizer that can be used for the basic properties of the patch or the range of use of the present invention while screening the stabilizer of the peroxide in the patch, and can significantly improve the stability over time at high temperatures of the peroxide in the patch. It became. Thus, a second feature of the invention is the use of a peroxide, a tooth whitening agent, with a peroxide stabilizer.

Peroxide stabilizers that are compatible with peroxides and can be used in oral products include alkyl aryl sulfonates, alkyl sulfonate salts, alkyl carboxylate salts, Span 20, Sorbitan Monolaurate, Span 40, Sorbitan Monopalmitate), Span 60 (Sorbitan Mono stearate), Span 80 (Span 80; Sorbitan Monooleate), Span 85 (Span 85, Sorbitan Trioleate), TWEEN (POE sorbitan fatty acid ester) system and mixtures thereof One or more selected from the group was used.

Among the peroxide stabilizers, alkyl diphenyl oxide disulfonate is a surfactant, but it is characterized by maintaining the transparency of the formulation when added to the prescription, the present invention also excellent in the peroxide stabilization effect in the patch when used as a peroxide stabilizer. However, there are some parts that are not suitable for the present formulation, which is not yet recognized as safety for oral products and may be eaten slightly when attaching teeth. Peroxide stabilizers, except alkyl diphenyl oxide disulfonates, have a good peroxide stabilizing effect when added to the formulation, but are opaque by emulsifying the adhesive preparation solution and semitransparent for dry type tooth whitening patches prepared by drying them. -transparent). However, unlike the opaque, which intentionally disperses the white pigment in the adhesive or backing layer to make it look white, the translucent effect of the addition of peroxide stabilizer is invisible to the user and the other person talking with him. It makes the teeth look whiter and has no obstacles in daily life, meeting the object of the present invention.

The reason for adding peroxide stabilizer in the present invention is that the peroxide is used as the main tooth whitening agent in the patch. When the patch is made with only the whitening agent, the peroxide content in the patch is stored over time even when stored at 40 ° C. As a result, the in vitro whitening effect was also lower than that of the first time. In the case of gel form, the formulation containing peroxide same as Adhesive had a very small peroxide loss without using a stabilizer even when the polymer was used as a film-forming agent, and a formulation lacking peroxide stability was known as a general peroxide stabilizer. By adding small amounts of chelating agents such as EDTA or sodium citrate, the desired level of prescription was obtained. However, in the case of the sheet-type patch obtained by evaporating the solvent of the gel as in the present invention, the stability of the peroxide was lower than that of the solution even when the same formulation was used. When the chelating agent was added as in the solution, the stability of the peroxide in the patch was lower than before the addition. Also, when the dequest phosphonates known to have excellent peroxide stabilizing effects were added to the patch, peroxide stabilizing effects could not be obtained.

There are various reasons why the peroxide over time stability in the prescription depends on whether the same composition is gel or liquid or sheet phase, but according to US Pat. No. 4,320,102, the amount of peroxide is very small due to the catalytic reaction by metal. It is said that even the only metal is very sensitive to decomposition. In other words, hydrogen peroxide decomposes even if only 0.1 mg of iron, 0.2 mg of copper, 0.1 mg of magnesium, and 0.02 mg of chromium per liter. Based on these data, sheet-shaped patches made by evaporation of solvent in solution or gel state contain relatively high amounts of metals in a thin thickness and are more responsive because their surface area increases. It is thought that stability with time of peroxide will become inadequate. In the present invention, materials used as peroxide stabilizers in patches are mainly surfactants or emulsifiers, which form micelles on sheets to prevent contact between raw materials and poorly compatible peroxides, or glass polymers having poor application properties. In this case, the whitening agent was uniformly dispersed throughout the patch, and the adhesive layer was uniformly applied, which is considered to have a positive effect on the peroxide stabilization. Indeed, the gels in the container had excellent stability over time at relatively high temperatures, while the same gel formulations were applied to the strips to increase the surface area. After evaluation of the stability over time, the residual peroxide ratio was significantly reduced over time. .

In addition, in the present invention, although the peroxide is used as the main whitening agent, condensed phosphate is used together with the peroxide as the whitening agent to improve the whitening effect.

Condensed polyphosphates used are, for example, tetrasodium pyrophosphate (TSPP), sodium pyrophosphate (SAPP), sodium hexametaphosphate (SHMP), sodium tripolyphosphate, STP), sodium potassium tripolyphosphate (SKTP), potassium pyrophosphate (TKPP), acidic sodium meta-polyphosphate (Sporix), multiphos (acidic sodium polyphosphate, Multiphos) One or more of them was used together with the peroxide. In general, condensed phosphates are known to be effective as tartar control agents in tartar control and to remove tartar. In addition, they are good chelating agents of metals, which can effectively remove tooth stains produced by metals such as iron, calcium, and magnesium in foods and working environments in the staining of teeth, which may contribute to the improvement of the whitening effect. . Therefore, when the polyphosphate is used in combination with the peroxide in the present invention, it is expected to be effective in inhibiting tartar formation or removing tartar by prolonging the contact time between teeth and polyphosphate as well as improving the whitening effect. In fact, when the patch containing these were attached, the tooth surface or between the teeth was cleared.

Polymers usable in the backing layer of the matrix patch in the present invention are polyvinyl acetate, ethyl cellulose, poly methyl methacrylate, methacrylic acid copolymers such as methacryloyl ethyl betaine / methacrylate copolymer (Yukaformer Manufacturers Mitsubishi, Metacryloyl Ethyl Betain / Metacylate Copolymer Aminoalkyl methacrylate copolymers (Eudragit E 100, Eudragit E 12,5, Eudragit RL 100, Eudragit RL 30D), cellulose acetate phthalate, Shellac alone or mixtures thereof. In addition, as an enteric coating material, any polymer that is insoluble in oral conditions between pH 6 and 8 can be used.

The backing layer can also be used with the addition of several plasticizers for the same reasons as the adhesive layer. In addition to the plasticizers mentioned above, propylene glycol, glycerin, polyethylene glycol and more can be used depending on the solvent used, and caster oil and hydrogenated caster oil can also be used.

Formulations used in the present invention may be used alone or in combination with enzymes, particularly dextranase, glucose oxidase, etc., which were difficult to apply due to stability over time when applied to toothpaste, and also added papain that is effective in whitening teeth. can do. Therapeutic medicinal products for oral disease include triclosan, chlorohexidin, vitamin E or derivatives thereof, including vitamin E acetate or oxidants, chlorophyll or derivatives thereof, and spices, which are effective for removing bad breath. It is possible.

Hereinafter, a preferred embodiment of the present invention. However, the following examples are merely to help the understanding of the present invention is not limited to the following examples.

Examples 1 to 8, Comparative Examples 1 to 5

Tooth whitening patches of Examples 1 to 9 and Comparative Examples 1 to 5 were prepared with the composition as described below.

Example 1

Adhesive Manufacturing Solution

Polyvinyl Alcohol 10%, Polyvinyl Pyrrolidone 3%, Pyroperoxide Peroxide 5%, Sorbitan Monolaurate 3%, Glycerin 3%, Water to 100

Backing Preparation Solution

Ethyl cellulose 8%, Eudragit 5%, caster oil 4%, ethanol to 100

Example 2

Adhesive Manufacturing Solution

Polyvinyl Pyrrolidone 10%, Hydrogen Peroxide 5%, Sorbitan Monoplamitate 3%, Glycerin 10%, Water to 100

Backing Preparation Solution

Polyvinyl Acetate 5%, Yukaformer (Mitsubishi) 5%, Glycerin 6%, Ethanol to 100

Example 3

Adhesive Manufacturing Solution

Polyquaternium-39 10%, urea peroxide 10%, Tween (POE sorbitan fatty acidester) 20 4%, water to 100

Backing Preparation Solution

Cellulose aceteart phthalate 30%, caster oil 4%, acetone: ethanol = 4: 1 mixed solution to 100

Example 4

Adhesive Manufacturing Solution

12% polyalkyl vinyl ether-maleic acid copolymer (Gantrez S 97), 6% sodium pyrophosphate peroxide, 1.0% Sorbitan Oleate, water to 100

Backing Preparation Solution

Ethyl cellulose 10%, caster oil 6%, ethanol to 100

Example 5

Adhesive Manufacturing Solution

12% polyalkyl vinyl ether-maleic acid copolymer (Gantrez S 97), 6% sodium peroxide pyrophosphate, 10% alkyl aryl sulfonate (SLS), NaOH (pH up to 7) water to 100

Backing Preparation Solution

Ethyl cellulose 10%, caster oil 6%, ethanol to 100

Example 6

Adhesive Manufacturing Solution

Polyalkyl vinyl ether-maleic acid copolymer (Gantrez S 97) 11%, polyvinyl pyrrolidone 3%, hydrogen peroxide 3%, SAPP 4%, alkyl sulfonate salt 2%, NaOH appropriate amount (pH upto 7) water to 100

Backing Preparation Solution

Polymethyl Methacrylate 8%, Acetone to 100

Example 7

Adhesive Manufacturing Solution

Polyquaternium-11 20%, PC 4%, TKPP 4%, Sorbitan Monolaurate 2%, Water to 100

Backing Preparation Solution

Eudragit 15%, Propylene Glycol 5%, Ethanolto 100

Example 8

Adhesive Manufacturing Solution

Polyvinyl Pyrrolidone 18%, Hydrogen Peroxide 1.5%, Sorbitan Monostearate 0.5%, NaOH up to pH 6.0, Waterto 100

Backing Preparation Solution

Ethyl cellulose 10%, Eudragit 2%, caster oil 7%, ethanol to 100

Comparative Example 1

Adhesive Gel

Carbopol 12%, hydrogen peroxide 4.5%, SAPP 0.48%, glycerin 80%, waterto 100

Backing floor

Polyethylene strip

Comparative Example 2

Adhesive Gel

Polyvinyl pyrrolidone 10%, polyethylene glycol 3%, urea peroxide 10%, alkyl diphenyl oxide disulfonate 2%, water to 100

Backing Preparation Solution

Ethyl cellulose 10%, caster oil 6%, ethanol to 100

Comparative Example 3

Adhesive Gel

Polyvinyl alcohol 12%, hydrogen peroxide 1.5%, TSPP 3.4%, propylene glycol 3%, hydroxyapatite 0.3%, water to 100

Backing Preparation Solution

Ethyl cellulose 8%, cellulose acetate phthalate 2% ethanol: acetone = 1: 4 mixed solvent to 100

Comparative Example 4

Adhesive Manufacturing Solution

Polyquaternium-11 20%, PC 4%, TKPP 4%, Water to 100

Backing Preparation Solution

Eudragit 15%, Propylene Glycol 5%, Titanium Dioxide 0.2%, Ethanolto 100

Comparative Example 5

Adhesive Manufacturing Solution

Polyalkyl vinyl ether-maleic acid copolymer (Gantrez S 97) 12%, fatigue peroxide sodium phosphate 6%, titanium dioxide 0.5%, NaOH (pH up to 7) water to 100

Backing Preparation Solution

Ethyl cellulose 10%, caster oil 6%, ethanol to 100

Backing Preparation Solution

Ethyl cellulose 12%, caster oil 6%, ethanolto 100

TKPP; tetrapotassium pyrophosphate, SAPP; sodium acid pyrophosphate, TSPP; tetrasodium pyrophosphate

Experimental Example 1

<Transparency of the patch and evaluation of the outstanding thing>

Ten people evaluated the transparency of the formulation obtained in Examples and Comparative Examples before responding with T (transparent) if transparent, semi-transparent (S) if transparent and O (opaque) if opaque, and actually worn by each person. If 9 people except yourself are noticed, give 1 point, if not, give 0 points (out of 9 points), and the degree of whiteness of teeth when worn is given from 1 to 3 points. One is Table 1.

Transparency Stand out Tooth whiteness when worn Example 1 S 0 2 Example 2 S 0 2 Example 3 S 0 2 Example 4 S 0 2 Example 5 S 0 2 Example 6 S 0 2 Example 7 S 0 2 Comparative Example 1 T 8 One Comparative Example 2 T 0 2 Comparative Example 3 O 6 3 Comparative Example 4 O 7 3 Comparative Example 5 O 9 3

Looking at Table 1, in the dry type patch of the embodiment, the transparency is semi-transparent, but it is inconspicuous when worn, and the teeth appear white when worn. In the dry type patch with the white pigment of the comparative example, the teeth looked very white, but the whiteness was not natural, so the wear was noticeable to others. In Comparative Example 1 in which the gel was applied to the strip, it was transparent, but it was noticeable when worn and the wearing state did not appear white.

Experimental Example 2

The stability over time of the peroxide at high temperature (40 ° C.) of the tooth whitening patch prepared according to the composition was evaluated by the following method.

(1) Evaluation method of peroxide content in the patch

Take a mixed solvent capable of dissolving both the backing layer and the adhesive layer of the patch in an Erlenmeyer flask, dissolve it completely by weighing the appropriate amount of patch correctly, add about 5 ml of 6 N hydrochloric acid, and about 2 g of potassium iodide. After thawing, the mixture was left in a cold dark cow for 1 hour and then titrated with 50 mM thiosulfate sodium solution to quantify peroxide content in the patch. The results are shown in Table 2 below.

Storage temperature: 40 ° C, storage condition: pouch packaging Residual Peroxide Ratio (%) Example 3 Example 8 Comparative Example 1 1 week 96% 100% 96% 2 weeks 89% 100% 91% 4 weeks 85% 100% 84% 6 Weeks 85% 94% 71% 8 Weeks 80% 90% 65%

As seen in Examples 3 and 8 and Comparative Example 1 in Table 2, the addition of the peroxide stabilizer was superior to the stability of the peroxide over time at high temperatures. In Comparative Example 1, the new type of whitening agent Crest Whitestrips of P & G of wet type was evaluated, and it was confirmed that the residual peroxide content in the patch rapidly decreased after 4 weeks. In Comparative Example 4, a glass polymer was used for the adhesive layer, but the compatibility with the peroxide was not good, but the peroxide stabilizer was not used together. At this time, the stability of the over time in the patch at high temperature was very poor.

As described above, the present invention is a dry type using a hydrophilic glassy polymer in the adhesive layer with excellent tooth whitening effect while hydrating upon contact with the tooth and release of adhesive and whitening agent is started. It is safer to use, it is convenient to use because it doesn't get in contact with hands or other body parts, and it has excellent peroxide stability in the patch at high temperature, and the patch is translucent before wearing, but it is not noticed by other people and does not interfere with conversation when worn. It is effective to provide a more convenient tooth whitening patch.

Claims (7)

Polyalkylvinylether-maleic acid copolymer (PVM / MA copolymer, Gantrez AN 119, AN 139, S- in a matrix type tooth enamel patch having an adhesive layer and a backing layer). 97), polyvinyl alcohol, polyacrylic acid, Poloxamer 407 (Pluronic), polyvinylpyrrolidone-vinylacetate copolymer (PVP / VA copolymer; Luviskol VA, Plasdone S PVP / VA), polyvinylpyrrolidone (PVP, K-30 ~ K-120), Polyquaternium-11 (Gafquat 755N), Polyquaternium-39 (Merquat plus 3330), Carbomer (Carbopol), hydroxypropylmethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, gelatin (Gelatin ) And one or more hydrophilic glass polymers selected from sodium alginate as bases in the adhesion layer, and alkylarylsulfonate, alkylsulfonate salt, alkylcarboxylate salt, span 20 with peroxide as tooth whitening agent. (Span 20, Sorbita Monolaurate, Span 40, Sorbitan Monopalmitate, Span 60, Sorbitan Monostearate, Span 80, Sorbitan Monooleate, Span 85, Sorbitan Trioleate, and TWEEN POE sorbitan fatty acid A semi-transparent dry type containing at least one peroxide stabilizer selected from esters and having a strong adhesive force as the hydrophilic glass polymer is hydrated by moisture on the surface of the tooth and releasing a whitening agent at the same time. Tooth whitening patch. delete The method of claim 1, wherein the peroxide is hydrogen peroxide, carbamide peroxide, calcium peroxide, sodium percarbonate, sodium perborate, sodium pyrophosphate, or tetrasodium pyrophosphate. peroxidate), or a mixture thereof. delete The tooth whitening patch of claim 1, further comprising a condensed phosphate for enhancing the whitening effect. The method of claim 5 wherein the condensed phosphate is tetrasodium pyrophosphate (TSPP), sodium acid pyrophosphate (SAPP), sodium hexametaphosphate (SHMP), sodium tripolyphosphate (STP), sodium potassium tripolyphosphate (SKTP), tetrapotassium pyrophosphate (TKPP) and acidic sodium metapolyphosphate (Sporix) Tooth whitening patch, characterized in that at least one selected from. The cellulose acetate phthalate, shellac, polyvinyl acetate, ethyl cellulose, polymethyl methacrylate, methacryloyl ethyl betaine / methacrylate copolymer (Yukaformer) according to claim 1, Metacryloyl Ethyl Betain / Metacylate Copolymer, methacrylic acid copolymers (Eudragit L 100, Eudragit L 12,5, Eudragit L 100-55, Eudragit L 30D-55), aminoalkyl methacrylate a patch for teeth whitening, comprising copolymers; Eudragit E 100, Eudragit E 12,5, Eudragit RL 100, Eudragit RL 30D) or mixtures thereof.