CN1703238B - 重组细胞内病原体免疫原组合物及其使用方法 - Google Patents

重组细胞内病原体免疫原组合物及其使用方法 Download PDF

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Publication number
CN1703238B
CN1703238B CN038254441A CN03825444A CN1703238B CN 1703238 B CN1703238 B CN 1703238B CN 038254441 A CN038254441 A CN 038254441A CN 03825444 A CN03825444 A CN 03825444A CN 1703238 B CN1703238 B CN 1703238B
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immunogenic composition
protein
extracellular protein
gene
bcg
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Chinese (zh)
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CN1703238A (zh
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M·A·霍威兹
G·哈斯
M·V·图利斯
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University of California San Diego UCSD
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University of California San Diego UCSD
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Priority claimed from US10/261,981 external-priority patent/US20030124135A1/en
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN038254441A 2002-09-30 2003-09-30 重组细胞内病原体免疫原组合物及其使用方法 Expired - Lifetime CN1703238B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10/261,981 US20030124135A1 (en) 2000-04-17 2002-09-30 Recombinant intracellular pathogen vaccines and methods for use
US10/261,981 2002-09-30
US10/439,611 2003-05-15
US10/439,611 US6924118B2 (en) 2000-04-17 2003-05-15 Recombinant intracellular pathogen immunogenic compositions and methods for use
PCT/US2003/030994 WO2004031356A2 (en) 2002-09-30 2003-09-30 Recombinant intracellular pathogen immunogenic compositions and methods for use

Publications (2)

Publication Number Publication Date
CN1703238A CN1703238A (zh) 2005-11-30
CN1703238B true CN1703238B (zh) 2012-05-30

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CN038254441A Expired - Lifetime CN1703238B (zh) 2002-09-30 2003-09-30 重组细胞内病原体免疫原组合物及其使用方法

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US (1) US6924118B2 (enExample)
EP (1) EP1556081B1 (enExample)
JP (1) JP2006501304A (enExample)
KR (1) KR101066951B1 (enExample)
CN (1) CN1703238B (enExample)
AT (1) ATE487489T1 (enExample)
AU (1) AU2003272808B2 (enExample)
BR (1) BR0314937A (enExample)
CA (1) CA2500433A1 (enExample)
MX (1) MXPA05003407A (enExample)
RU (1) RU2337707C2 (enExample)
WO (1) WO2004031356A2 (enExample)
ZA (1) ZA200502596B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6924118B2 (en) 2000-04-17 2005-08-02 The Regents Of The University Of California Recombinant intracellular pathogen immunogenic compositions and methods for use
EP2206514B1 (en) * 2003-10-16 2014-01-08 The Regents of The University of California Recombinant intracellular pathogen immunogenic compositions and methods for use
US8383132B2 (en) * 2003-10-16 2013-02-26 The Regents Of The University Of California Immunostimulatory recombinant intracellular pathogen immunogenic compositions and methods of use
US8163294B2 (en) * 2003-10-16 2012-04-24 The Regents Of The University Of California Growth regulatable recombinant BCG compositions
WO2007121194A1 (en) * 2006-04-10 2007-10-25 The Regents Of The University Of California Immunostimulatory recombinant intracellular pathogen immunogenic compositions and methods of use
AP2007004033A0 (en) * 2004-12-01 2007-06-30 Aeras Global Tb Baccine Founda Recombinant bcg strains with enhanced ability to escape the endosome
WO2012020927A1 (ko) 2010-08-09 2012-02-16 에스케이텔레콤 주식회사 통합 영상 검색 시스템 및 그 서비스 방법
RU2517218C1 (ru) * 2012-10-25 2014-05-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования Курская государственная сельскохозяйственная академия имени профессора И.И. Иванова Министерства сельского хозяйства Российской Федерации Способ моделирования гиперчувствительности замедленного типа у морских свинок на микобактерии m.bovis
CN113999865B (zh) * 2021-10-09 2023-06-16 安徽理工大学 结核分枝杆菌融合蛋白ar2及其构建与表达纯化方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001078774A2 (en) * 2000-04-17 2001-10-25 Regents Of The University Of California Recombinant intracellular pathogen vaccines and methods for use

Family Cites Families (12)

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Publication number Priority date Publication date Assignee Title
US5807723A (en) 1987-03-02 1998-09-15 Whitehead Institute For Biomedical Research Homologously recombinant slow growing mycobacteria and uses therefor
JP3011939B2 (ja) 1987-03-02 2000-02-21 ホワイトヘツド・インスチチユート・フオー・バイオメデイカル・リサーチ 組換えミコバクテリア・ワクチン
US5504005A (en) 1987-03-02 1996-04-02 Albert Einstein College Of Medicine Of Yeshiva University Recombinant mycobacterial vaccine
US5591632A (en) 1987-03-02 1997-01-07 Beth Israel Hospital Recombinant BCG
JP2903414B2 (ja) 1989-05-31 1999-06-07 味の素株式会社 抗酸菌分泌発現ベクター及び抗酸菌
AU681572B2 (en) 1991-10-21 1997-09-04 Med Immune, Inc. Bacterial expression vectors containing DNA encoding secretion signals of lipoproteins
US5736367A (en) 1992-03-31 1998-04-07 Medimmune, Inc. Vectors and prokaryotes which autocatalytically delete antibiotic resistance
US5679515A (en) 1994-10-03 1997-10-21 Pathogenesis Corporation Mycobacterial reporter strains and uses thereof
US5700683A (en) 1995-02-17 1997-12-23 Pathogenesis Corporation Virulence-attenuating genetic deletions deleted from mycobacterium BCG
US5869057A (en) 1995-06-07 1999-02-09 Rock; Edwin P. Recombinant vaccines to break self-tolerance
RU2112543C1 (ru) * 1996-09-26 1998-06-10 Александр Григорьевич Хоменко Иммуномодулирующее лекарственное средство
US6924118B2 (en) 2000-04-17 2005-08-02 The Regents Of The University Of California Recombinant intracellular pathogen immunogenic compositions and methods for use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001078774A2 (en) * 2000-04-17 2001-10-25 Regents Of The University Of California Recombinant intracellular pathogen vaccines and methods for use

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Guleria I, et al..Auxotrophic vaccines for tuberculosis..Nature Medicine.2 3.1996,2(3),334-337.
Guleria I, et al..Auxotrophic vaccines for tuberculosis..Nature Medicine.2 3.1996,2(3),334-337. *
Tanya Parish, et al..Production of mutants in amino acid biosynthesis genesofMycobacterium tuberculosis by homologous recombination.Microbiology145.1999,1453497-3503. *

Also Published As

Publication number Publication date
US6924118B2 (en) 2005-08-02
CA2500433A1 (en) 2004-04-15
KR20050075343A (ko) 2005-07-20
MXPA05003407A (es) 2005-08-02
BR0314937A (pt) 2005-08-02
AU2003272808A1 (en) 2004-04-23
EP1556081A2 (en) 2005-07-27
WO2004031356A3 (en) 2004-08-26
ZA200502596B (en) 2005-12-28
EP1556081A4 (en) 2006-10-25
RU2005113266A (ru) 2006-01-20
US20040009184A1 (en) 2004-01-15
KR101066951B1 (ko) 2011-09-23
WO2004031356A2 (en) 2004-04-15
ATE487489T1 (de) 2010-11-15
JP2006501304A (ja) 2006-01-12
RU2337707C2 (ru) 2008-11-10
EP1556081B1 (en) 2010-11-10
AU2003272808B2 (en) 2010-01-21
CN1703238A (zh) 2005-11-30

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