CN1674868B - 包含药物、软膏基质和增溶剂/分散剂的眼用软膏剂组合物 - Google Patents

包含药物、软膏基质和增溶剂/分散剂的眼用软膏剂组合物 Download PDF

Info

Publication number
CN1674868B
CN1674868B CN038172089A CN03817208A CN1674868B CN 1674868 B CN1674868 B CN 1674868B CN 038172089 A CN038172089 A CN 038172089A CN 03817208 A CN03817208 A CN 03817208A CN 1674868 B CN1674868 B CN 1674868B
Authority
CN
China
Prior art keywords
compositions
ointment base
ointment
weight
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN038172089A
Other languages
English (en)
Chinese (zh)
Other versions
CN1674868A (zh
Inventor
J·奥库努鲁
M·巴比奥勒索尼耶
J-C·比泽克
G·L·基斯
C·肖赫
M·P-H·翁
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of CN1674868A publication Critical patent/CN1674868A/zh
Application granted granted Critical
Publication of CN1674868B publication Critical patent/CN1674868B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN038172089A 2002-07-23 2003-07-22 包含药物、软膏基质和增溶剂/分散剂的眼用软膏剂组合物 Expired - Fee Related CN1674868B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39786502P 2002-07-23 2002-07-23
US60/397,865 2002-07-23
PCT/EP2003/008005 WO2004009056A1 (en) 2002-07-23 2003-07-22 Ophtalmic ointment composition comprising a drug, an ointment base and a solubiling/dispersing agent

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN2010102484792A Division CN101897662B (zh) 2002-07-23 2003-07-22 包含药物、软膏基质和增溶剂/分散剂的眼用软膏剂组合物

Publications (2)

Publication Number Publication Date
CN1674868A CN1674868A (zh) 2005-09-28
CN1674868B true CN1674868B (zh) 2010-09-29

Family

ID=30771133

Family Applications (2)

Application Number Title Priority Date Filing Date
CN038172089A Expired - Fee Related CN1674868B (zh) 2002-07-23 2003-07-22 包含药物、软膏基质和增溶剂/分散剂的眼用软膏剂组合物
CN2010102484792A Expired - Fee Related CN101897662B (zh) 2002-07-23 2003-07-22 包含药物、软膏基质和增溶剂/分散剂的眼用软膏剂组合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN2010102484792A Expired - Fee Related CN101897662B (zh) 2002-07-23 2003-07-22 包含药物、软膏基质和增溶剂/分散剂的眼用软膏剂组合物

Country Status (8)

Country Link
US (2) US20060115500A1 (enExample)
EP (2) EP2319493A3 (enExample)
JP (2) JP2005536516A (enExample)
CN (2) CN1674868B (enExample)
AU (1) AU2003254566A1 (enExample)
BR (1) BR0312817A (enExample)
CA (1) CA2492989C (enExample)
WO (1) WO2004009056A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006019851A1 (en) * 2004-07-23 2006-02-23 Eli Lilly And Company Methods for diagnosing and treating diabetic microvascular complications
US20100160293A1 (en) * 2005-02-17 2010-06-24 Kakuji Tojo Solid Ophthalmic Drug for External Use
CA2659775A1 (en) * 2006-08-04 2008-02-14 Insys Therapeutics Inc. Aqueous dronabinol formulations
KR20100072333A (ko) * 2007-11-01 2010-06-30 보오슈 앤드 롬 인코포레이팃드 약물 전달을 위한 비히클로서의 비-수성 수혼화성 물질
JP5997612B2 (ja) 2009-12-08 2016-09-28 スミス アンド ネフュー オーソペディックス アーゲーＳｍｉｔｈ ＆ Ｎｅｐｈｅｗ Ｏｒｔｈｏｐａｅｄｉｃｓ ＡＧ 増幅された酵素活性の酵素創傷壊死組織除去組成物
US9463201B2 (en) 2014-10-19 2016-10-11 M.G. Therapeutics Ltd Compositions and methods for the treatment of meibomian gland dysfunction
KR20180090251A (ko) 2015-09-28 2018-08-10 아주라 오프탈믹스 엘티디 마이봄샘 지질 분비를 증가시키기 위한 티올 및 이황화물 함유 약제
EP3442519A4 (en) 2016-04-14 2019-12-04 Azura Opthalmics Ltd. SELDISULFID COMPOSITIONS FOR USE IN THE TREATMENT OF THE MEIBOM DRESSING DYSFUNCTION
EP3741367A1 (en) * 2019-05-21 2020-11-25 Premark Pharma GmbH Treatment of ocular disease
CN115279458A (zh) 2020-01-10 2022-11-01 阿祖拉眼科有限公司 组合物和敏感性说明

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1323207A (zh) * 1998-10-14 2001-11-21 诺瓦提斯公司 含有维生素a和维生素e的眼药组合物的用途
WO2001095878A1 (en) * 2000-06-14 2001-12-20 EGIS Gyógyszergyár Rt. Process for the preparation of a sterile ointment containing acyclovir

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3134718A (en) * 1963-12-12 1964-05-26 Schering Corp Pregna-1,4-dienes and compositions containing same
US3453257A (en) 1967-02-13 1969-07-01 Corn Products Co Cyclodextrin with cationic properties
GB1537047A (en) * 1975-10-03 1978-12-29 Fisons Ltd Eye ointment
US4432964A (en) * 1981-08-24 1984-02-21 Alza Corporation Topical composition containing steroid in two forms released independently from polymeric carrier
CA1196284A (en) * 1982-05-28 1985-11-05 Joshua Oduro-Yeboah Pharmaceutical formulations
US4966773A (en) * 1986-11-25 1990-10-30 Alcon Laboratories, Inc. Topical ophthalmic compositions containing microfine retinoid particles
US5093330A (en) * 1987-06-15 1992-03-03 Ciba-Geigy Corporation Staurosporine derivatives substituted at methylamino nitrogen
IL86632A0 (en) * 1987-06-15 1988-11-30 Ciba Geigy Ag Derivatives substituted at methyl-amino nitrogen
JPS644125A (en) * 1987-06-26 1989-01-09 Hitachi Ltd Communication satellite identification system
IT1222309B (it) * 1987-07-08 1990-09-05 Menarini Sas Utilizzazione di forme farmaceutiche per uso topico contenenti miocamicina per la terapia delle infezione da germi sensibili alla miocamicina stessa
JP2865324B2 (ja) * 1989-09-29 1999-03-08 東京田辺製薬株式会社 ９―メチル―３―（１Ｈ―テトラゾール―５―イル）―４Ｈ―ピリド［１，２―ａ］ピリミジン―４―オン又はその塩の軟膏剤
DE69021833T2 (de) 1989-11-09 1996-03-21 Sandoz Ag Heteroatome enthaltende tricyclische Verbindungen.
US5241059A (en) 1990-05-21 1993-08-31 Toppan Printing Co., Ltd. Cyclodextrin derivatives
DK0474126T3 (enExample) * 1990-09-04 1997-04-07 Fujisawa Pharmaceutical Co
DK196591D0 (da) * 1991-12-05 1991-12-05 Mouritsen & Elsner Aps Anvendelse af en kendt kemisk forbindelse til fremstilling af et farmaceutisk paraeparat til topisk applikation
HUT66531A (en) 1992-05-07 1994-12-28 Sandoz Ag Heteroatoms-containing tricyclic compounds, pharmaceutical prepns contg. them and process for producing them
MY110603A (en) 1993-05-27 1998-08-29 Novartis Ag Tetrahydropyran derivatives
US5599808A (en) * 1994-02-18 1997-02-04 Cephalon, Inc. Aqueous indolocarbazole solutions
AU3609795A (en) * 1994-10-10 1996-05-02 Novartis Ag Ophthalmic and aural compositions containing diclofenac potassium
EP0711557A1 (de) * 1994-11-09 1996-05-15 Ciba-Geigy Ag Pharmazeutische Formulierungsgrundlage
EP0848717A1 (en) 1995-08-24 1998-06-24 Merck & Co., Inc. Process for the preparation of imidazolyl macrolide immunosuppressants
JPH0977662A (ja) * 1995-09-11 1997-03-25 Zeria Pharmaceut Co Ltd 軟膏剤
UA54427C2 (uk) * 1996-05-01 2003-03-17 Елі Ліллі Енд Компані Спосіб лікування очних захворювань, які пов'язані з фактором васкулярного ендотеліального росту
JPH10203979A (ja) * 1997-01-24 1998-08-04 Rohto Pharmaceut Co Ltd チアプロフェン酸を含有する抗眼炎症剤
CO4960662A1 (es) 1997-08-28 2000-09-25 Novartis Ag Ciertos acidos 5-alquil-2-arilaminofenilaceticos y sus derivados
IT1295423B1 (it) * 1997-10-10 1999-05-12 Medivis S R L Uso della flunarizina nella terapia topica del glaucoma
FR2772271B1 (fr) * 1997-12-11 2000-09-01 Union Pharma Scient Appl Nouvelle association pharmaceutique a activite analgesique
KR100627620B1 (ko) * 1998-05-15 2006-09-25 와카모토 세이야꾸 가부시끼가이샤 항염증 점안제
US6200968B1 (en) * 1998-08-06 2001-03-13 Cephalon, Inc. Particle-forming compositions containing fused pyrrolocarbazoles
ID29970A (id) * 1998-11-23 2001-10-25 Novartis Ag Metode untuk mengobati penyakit neovaskuler okuler
GB9903547D0 (en) * 1999-02-16 1999-04-07 Novartis Ag Organic compounds
ITMI991453A1 (it) * 1999-07-01 2001-01-01 Farmila Farma Milano Composizioni oftalmiche in forma di gel acquosi
US6271233B1 (en) 1999-08-10 2001-08-07 Ciba Vision Corporation Method for treating ocular neovascular diseases
CN1127955C (zh) * 2000-07-07 2003-11-19 中山医科大学中山眼科中心 一种眼前段及眼表免疫相关性疾病治疗药物
AR038628A1 (es) * 2002-03-04 2005-01-19 Novartis Ag Composicion oftalmica

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1323207A (zh) * 1998-10-14 2001-11-21 诺瓦提斯公司 含有维生素a和维生素e的眼药组合物的用途
WO2001095878A1 (en) * 2000-06-14 2001-12-20 EGIS Gyógyszergyár Rt. Process for the preparation of a sterile ointment containing acyclovir

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Fabgro D. et. al.."PKC412--a protein kinase inhibitor with abroadtherapeuticpotential.".Anticancer Drug Des.15 1.2000,15(1),17.
Fabgro D. et. al.."PKC412-a protein kinase inhibitor with abroadtherapeuticpotential.".Anticancer Drug Des.15 1.2000,15(1),17. *
Mayer K. et. al.."FK506 intment 0.1% - A new therapeutic optionforatopicblepharitis. Clinical trial with 14 patients".Klin Monatsbl Augenheilkd218 11.2001,218(11),733.
Mayer K. et. al.."FK506 intment 0.1%-A new therapeutic optionforatopicblepharitis. Clinical trial with 14 patients".Klin Monatsbl Augenheilkd218 11.2001,218(11),733. *
姚小莉.维生素E与眼.眼外伤职业眼病杂志21 6.1999,21(6),636-637.
姚小莉.维生素E与眼.眼外伤职业眼病杂志21 6.1999,21(6),636-637. *

Also Published As

Publication number Publication date
BR0312817A (pt) 2005-04-19
CN101897662A (zh) 2010-12-01
EP1531793A1 (en) 2005-05-25
JP2005536516A (ja) 2005-12-02
JP2012087146A (ja) 2012-05-10
WO2004009056A1 (en) 2004-01-29
US20140005171A1 (en) 2014-01-02
CA2492989C (en) 2012-11-20
US20060115500A1 (en) 2006-06-01
EP2319493A3 (en) 2011-07-27
CN1674868A (zh) 2005-09-28
CA2492989A1 (en) 2004-01-29
EP2319493A2 (en) 2011-05-11
AU2003254566A1 (en) 2004-02-09
CN101897662B (zh) 2013-05-22

Similar Documents

Publication Publication Date Title
JP2012087146A (ja) 薬剤、軟膏基剤および可溶化剤／分散剤を含む、眼科用軟膏組成物
EP1848431B1 (en) Liquid formulations for treatment of diseases or conditions
US20110152307A1 (en) Ophthalmic composition comprising ascomycin
JP6824270B2 (ja) 生物活性親油性化合物を有するｐｅｇ化脂質ナノ粒子
JP2008543775A (ja) 眼の障害を治療するための方法および組成物
WO2010059894A1 (en) Ocular formulations of norketotifen
BR112016015763B1 (pt) Preparação farmacêutica incluindo composto de ácido piridilaminoacético, e, uso da mesma
KR20150100670A (ko) 레고라페닙을 함유하는 국소 안과 제약 조성물
JP5681472B2 (ja) 眼科用組成物
PT1682131E (pt) Cci-779 para o tratamento do linfoma de células do manto
WO2024209038A1 (en) Use of pimecrolimus for the treatment of dry eye in patients characterized by a corneal staining score of 4 or 5 on the oxford grading scale
HK1071301B (en) Ophthalmic composition comprising ascomycin
HK1110215B (en) Liquid formulations for treatment of diseases or conditions
ZA200406492B (en) Ophthalmic composition comrpising ascomycin

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C56 Change in the name or address of the patentee

Owner name: NOVARTIS CO., LTD.

Free format text: FORMER NAME: NOVARTIS AG

CP01 Change in the name or title of a patent holder

Address after: Basel

Patentee after: Novartis Ag

Address before: Basel

Patentee before: Novartis AG

CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20100929

Termination date: 20140722

EXPY Termination of patent right or utility model