CN1674854A - A capsule filling machine - Google Patents

A capsule filling machine Download PDF

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Publication number
CN1674854A
CN1674854A CNA038188864A CN03818886A CN1674854A CN 1674854 A CN1674854 A CN 1674854A CN A038188864 A CNA038188864 A CN A038188864A CN 03818886 A CN03818886 A CN 03818886A CN 1674854 A CN1674854 A CN 1674854A
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CN
China
Prior art keywords
capsule
operating position
rotating disk
shower nozzle
pneumatic means
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CNA038188864A
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Chinese (zh)
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CN100404014C (en
Inventor
R·特雷比
E·泽尔比纳蒂
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I.M.A.工业机械自动装置股份公司
IMA Industria Macchine Automatiche SpA
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IMA Industria Macchine Automatiche SpA
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Publication of CN1674854A publication Critical patent/CN1674854A/en
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Publication of CN100404014C publication Critical patent/CN100404014C/en
Anticipated expiration legal-status Critical
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B35/00Supplying, feeding, arranging or orientating articles to be packaged
    • B65B35/06Separating single articles from loose masses of articles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/074Filling capsules; Related operations
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B37/00Supplying or feeding fluent-solid, plastic, or liquid material, or loose masses of small articles, to be packaged
    • B65B37/14Supplying or feeding fluent-solid, plastic, or liquid material, or loose masses of small articles, to be packaged by pneumatic feeders
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B37/00Supplying or feeding fluent-solid, plastic, or liquid material, or loose masses of small articles, to be packaged
    • B65B37/16Separating measured quantities from supply

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Basic Packing Technique (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicinal Preparation (AREA)
  • Formation And Processing Of Food Products (AREA)
  • Eye Examination Apparatus (AREA)
  • Lighting Device Outwards From Vehicle And Optical Signal (AREA)
  • Centrifugal Separators (AREA)

Abstract

A capsule filling machine (10) for the production of hard gelatin capsules (C)of the type with a capsule lid and a capsule body (13, 14) containing pharmaceutical micro-tablets (12) comprises a first rotary carrousel (2) supporting a plurality of slide units (3) for picking up and handling capsules (C) in order to open then close the capsules (C) by separating then joining the capsule lids (13) and the capsule bodies (14); a second carrousel (4), which rotates in such a way that it is synchronized with the first carousel (2), having a plurality of reciprocating doser means (21)'' moving between a first operating position in which the doser means (21) are designed to pick up particulate material (12) from a tank (11) containing the material which is attached to the machine (10) and a second operating position in which they release the material into the capsule (C) bodies (14). The doser means (21) each comprise a hollow nozzle (22) with a plurality of seats (25) on its edge for picking up and holding the particulate pharmaceutical material (12), each seat (25) communicating with pneumatic means (24,24a,24b), the pneumatic means (24,24a,24b) comprising pneumatic vacuum means (24a) which, in the first operating position, suck up and hold individual particles (12) of the material in respective seats (25) of the nozzle (22), and pressurised pneumatic means (24b) which generate a flow that discharges the particles (12) from the seats (25) in the second operating position to release the material into the capsule (C) bodies (14).

Description

Capsule filler
The present invention relates to capsule filler, be used to produce the hard colloid capsule that comprises medicine.
Specifically be, the such hard gelatin capsules of the most suitable production of the present invention, the medicine in this hard gelatin capsules is a grain shape, i.e. tabloid shape or piller shape, this capsule has capsule lid and capsule body.
Background technology
In general, use the capsule filler of known type to consist essentially of central turnplate or rotary table now, this rotating disk rotates in the mode that interrupted rotation or stepping are rotated, and has many operating units, these unit are along the configuration of the end of rotating disk, are driven by rotating disk by driver part back and forth.
In accordance with known methods, each operating unit on rotating disk comprises the sliding bearing parts, is used for one or more capsule is sent to many workbench that carry out various operating procedures in succession.For example, carry the capsule of sealing and make capsule tilt to place, open each capsule subsequently, promptly, capsule body and capsule lid are separated, subsequently a certain amount of medicine is sent into capsule body, seal each capsule body with corresponding capsule lid then, discharge the capsule of expiring medicine of the sealing of producing by this way at last.
In this operation cycle, the metering units of known type comprises hollow punch respectively, this drift forms cylindrical shape, comprise piston (driving with Pneumatic method usually), this metering units is gathered medicine, and method is, this cylinder is swelled in the bucket that medicine is housed that is connected in rotating disk, piston is moved upward, measure, be about to medicine and be contained in and before soak in the bucket in the cylinder.
Cylinder is proposed from bucket, strike off or clear away step subsequently, remove after the too much tabloid medicine, driven plunger is to down stroke, thereby will be pushed into according to the pharmaceutical preparation of cylinder chamber volume metering in succession in the capsule body with corresponding cylinder collimation.
Now, can measure the powder shape medicine effectively and accurately with above-mentioned metering units, if but with granule medicament or tabloid or piller capsule charge, just then this metering is not too accurate.
Though piston can collect the powder medicaments of accurate constant basis in the hollow cylinder, under the situation of tabloid, piston can not apply enough captivations to tabloid, guarantees to gather the tabloid of constant, numbers, is put into subsequently in each capsule body.
Brief summary of the invention
The objective of the invention is to produce a kind of capsule filler, this filling machine can overcome the shortcoming of above-mentioned prior art.
Specifically be to the objective of the invention is to make a kind of capsule filler that can guarantee the high accuracy metering.
Another object of the present invention provides a kind of capsule filler, this filling machine combines with above-mentioned metering device accurately, can guarantee the needed reliability of this machine, production efficiency, safety and represent the particularly speed of production of high production rate continued operation capsule filler of modern capsule filler.
Therefore the invention provides the capsular capsule filler of a kind of production hard colloid, this capsule has capsule lid and packs the particularly capsule body of tabloid or piller of granule medicament into, this machine comprises: first rotating disk, this rotating disk supports many sliding units, be used to pick up and handle capsule, so that by capsule lid and capsule body are separated, cover then, open and seal this capsule; Second rotating disk, this rotating disk and first rotating disk rotate synchronously, this second rotating disk has many reciprocating metering devices, this metering device moves between first operating position and second operating position, when primary importance, this metering device be designed to can from be connected in machine comprise medicine the bucket gather medicine, when the second position, this metering device with drug release in capsule body.This machine is characterised in that, this metering device is included in its end respectively to have and is permitted porous hollow shower nozzle, be used to pick up and keep granular medicament, each hole communicates with pneumatic means, this pneumatic means comprises evacuation pneumatic means and supercharging pneumatic means, the former is when first operating position, discrete drug particles is drawn into and remains in the corresponding shower nozzle hole, the latter produces one air-flow at second operating position, drug particles is blown out from the hole, thereby said medicine is discharged in the capsule body.
Brief description of drawings
Be elaborated below with reference to accompanying drawing, can obviously find out the features and advantages of the present invention thus, these accompanying drawings illustrate the preferred embodiments of the present invention, but do not limit the scope of the principle of the invention, and these accompanying drawings are:
Fig. 1 is a sketch map, and the operation cycle of capsule filler of the present invention is shown;
Fig. 2 and 3 is side views, capsule filler that the present invention makes is shown in the details in two different operating stages, and some parts is cut off among the figure, and other parts are cross-sectional views;
Fig. 4 is a front view, and part is a sectional view, and the details of capsule filler particular component shown in Fig. 2 and 3 is shown;
Fig. 5 is a cross-sectional view, and parts shown in Figure 4 are shown;
Fig. 6 is a detail view, and the part of capsule filler shown in Figure 1 is shown.
The detailed description of the preferred embodiment of the present invention
With reference to figure 1, shown capsule filler is generally designated by numeral 10, this filling machine is used for a certain amount of drug particles 12 particularly medicine tabloid 12 or piller, be filled among the capsule C with capsule lid and capsule body of known type, this capsule lid and capsule body are represented with numbering 13 and 14 respectively.
Shown in Fig. 1,2 and 3, this capsule filler 10 comprises first rotating disk 2 and bucket 11, the former can rotate around vertical axis Z along the direction that arrow L represents, and have the supporting many sliding units 3 radially adjutage 2a, 2b, this sliding unit is used to pick up the capsule body 14 of capsule C, and this main body along continuous straight runs is moved, and the latter has known cardinal principle annular shape, be configured in the bottom of capsule filler 10, be designed to keep a large amount of pillers 12 that transport from transfer hopper 30.
This filling machine 10 also comprises second rotating disk 4 (Fig. 2), and this rotating disk also rotates around axis Z, and is to rotate along the direction shown in Fig. 1 arrow L, rotates synchronously with first rotating disk 2.This rotating disk 4 has the metering device 21 of many metering tabloids 12.
Shown in 2,3 and 6, this metering device 21 can be alternately movable between the first pick-up operation position (Fig. 2 and 6) and second operating position along the vertical direction that is parallel to the Z axle, when first operating position, device 21 inserts in the bucket 11 that comprises tabloid 12, pick up the medication amount that constitutes by the independent tabloid 12 of some, when second operating position, this a certain amount of tabloid 12 is discharged in the capsule body 14 of capsule C (Fig. 3).
According to the known method shown in Fig. 1,2 and 3, first rotating disk 2 takes out the capsule C (capsule of known type from the top hopper that comprises capsulae vacuus C, not shown), then capsule C distinctly is placed on the pick device 3, each pick device comprises two sleeves 15 and 17 that are used to tilt and control capsule C.Handle each capsule C with operating procedure in succession, these steps are, capsule lid 13 and corresponding capsule body 14 are separated, open, utilize metering device 21 that a certain amount of tabloid 12 is incapsulated main body 14 capsule C, cover this capsule body 14 with capsule lid 13 then, at last the capsule C that installs is discharged (Fig. 1) from capsule filler 10 through exporting and draw off region S.
Illustrate as Fig. 4 is clear, each metering device comprises the cylinder bar 20 with free end 20a, and the end of this free end has many holes or opening 25, is used to pick up and keeps each tabloid 12.
Each opening of going up endways also has pneumatic means 24 (Fig. 2), specifically is, the pneumatic means 24b of vacuum pneumatic means 24a and generation pressurized air stream.Device 24a designs like this, make when first operating position, this device picks up the tabloid 12 of some by suction, it is remained in the respective openings 25 on the end, and device 24b designs like this, make that when second operating position this device utilizes the pneumatic thrust that penetrates from opening 25, and these tabloids 12 are discharged in the capsule body 14.
Specifically be that the size of each opening 25 preferably is equivalent to be contained in the size of tabloid 12 in the bucket 11.Like this, configuration and keep individual dice agent 12 to cause opening 12 is closed exactly in opening 25.
In addition as shown in Figure 4, each opening 25 cross sections are preferably round-shaped, make it can form the cylinder chamber that is communicated with pneumatic means 24 through pipe 27.
Can not know that as Figure 4 and 5 the opening of going up endways 25 disposes like this, make these openings separate angle same with respect to the longitudinal axis Z ' of cylinder bar 20.These openings are configured on two and a plurality of adjacent horizontal planes.
Between opening 25 going up endways and the adjacent opening, the angle that opening separates preferably is about 120 ° angle [alpha].
Pneumatic means 24 also is included in the central passage 18 in the cylinder bar, and the air that is used to make air pressurized or form vacuum flows to terminal opening 25 through pipe 27.
The above-mentioned end 20a that freely picks up is made of the shower nozzle with tubular body (nozzle) 22, and the center drum chamber of this tubular body 23 has necking down in the end, and this necking down is designed to form central passage 18, is used for by forming the air of vacuum.
Top with shower nozzle 22 of tubular body is connected in vertical hollow rod by join domain 26 again, forms cylinder bar 20.
As shown in Figure 2, this hollow stem 20 is connected in the selector valve device 50 of control pneumatic means 24.
This selector valve device 50 preferably is configured on second rotating disk 4, and in the first pick-up operation position shown in Figure 2, it is the position that shower nozzle 22 inserts a large amount of tabloids 12 in the bucket 11, aspirator 24a is connected in opening 25, perhaps at second operating position, promptly this tabloid 12 is discharged into the position of capsule body 14, switches to the air assembly 24b that opening 25 is connected in supercharging by pneumatic discharge tabloid 12.
Specifically be that in order correctly tabloid 12 to be discharged in the capsule body 14, the arm 2a of first rotating disk 2 has chamber 19, this chamber is essentially funnel shaped, be designed to when the second releasing operation position, can combine, help tabloid 12 is discharged in the capsule body 14 with shower nozzle 22.
Can find out the operation of above-mentioned capsule filler 10 easily from above-mentioned explanation.
Suitably reinforced rotating disk 30 is transported to tabloid 12 in the bucket 11, and this capsule filler 10 can be opened capsule, capsule charge in order, closes capsule, discharge capsular step from filling machine 10 at last, automatically performs the filling operation of all capsule C.
Specifically be, utilize a kind of operation to carry out the filling step, can from bucket 11, pick up the tabloid 12 of predetermined number thus.
This filling operating procedure is, the hollow stem 20 that will have shower nozzle 22 is inserted in a large amount of tabloids 12, drives aspirator 24a then, and this aspirator becomes the vacuum that can form predetermined vacuum level, make shower nozzle 22 tabloid 12 can be attracted in the hole 25, and remain in this hole.
In a known manner bar 22 is risen to position shown in Figure 3 then, and move horizontally the sleeve 17 that carries capsule body 14, this capsule body is taken exactly to the position that is positioned at below the funnel-shaped chamber 19.
At this moment, selector valve device 50 switches hollow stem 20, makes it switch to and be connected in pressurized air device 24b from being connected in aspirator 24a.
So just, each tabloid 12 that remains in the respective openings 25 can be discharged in the infundibulate chamber 19, these tabloids enter into the capsule body 14 of the capsule C of positive filling from cavity then.
At this moment, the sleeve 17 that will support capsule body 14 again moves to position shown in Figure 2, continues to rotate with upper sleeve along the path circumscribed shown in Fig. 1 sketch map.
Therefore above-mentioned filling machine utilizes a kind of simple feeding nozzle structure to reach predetermined purpose, and this shower nozzle can accurately measure the tabloid number that incapsulates.When test, for each shower nozzle 22, can use the number of opening 25, thereby measure the result with the number optimization of tabloid 12, this number of openings changes between 13-30.
Because this structure of picking up shower nozzle, can utilize the number of the opening 25 of shower nozzle 22 accurately to determine the accurate constant tabloid 12 of quantity of each capsule of filling C capsule body 14 because in each opening 25 the single tabloid 12 of sticking only.
Clearly, the number that changes the pick device split shed can change the number of tabloid, thereby changes tabloid.
As change the cavity shape that the shower nozzle upper shed forms, can change the size of opening.On each shower nozzle total number of openings, the distribution that is distributed in number of openings on each plane and is their angle also can change.Therefore there are other embodiment of shower nozzle, comprise join domain and lower passage.
Be connected in hollow stem be used to bleed and the pneumatic means of pressurization gas, can for different kinds with have different power, this depends on application.
The present invention can have other suitable modification, and does not exceed the scope as the principle of the invention as described in claims.

Claims (4)

1. capsule charge device (10) that is used for production hard colloid capsule (C), this capsule comprises capsule lid and capsule body (13,14), drug particles (12), particularly tabloid (12) or piller are housed, and this machine (10) comprising: first rotating disk (2), this rotating disk supports many sliding units (3), be used to pick up and handle capsule (C),, open and close this capsule (C) thus so that capsule lid (13) and capsule body (14) are separately combined then; Second rotating disk (4), this rotating disk and first rotating disk (2) rotate synchronously, this second rotating disk has many reciprocating metering devices (21), this metering device can move between first operating position and second operating position, when first operating position, this metering device (21) is designed to and can picks up granule medicament (12) from the bucket (11) that comprises medicine that is connected in filling machine (10), when second operating position, this metering device can be with drug release in the main body (14) of capsule (C); This filling machine is characterised in that, each metering device (21) comprises hollow shower nozzle (22), the edge of this shower nozzle has many holes (25), be used to pick up granule medicament (12), and keep this medicine, each hole (25) and pneumatic means (24,24a, 24b) communicate, and this pneumatic means (24,24a, 24b) comprise evacuation pneumatic means (24a) and supercharging pneumatic means (24b), the former will aspirate single particle medicine (12) in the respective aperture (25) of suction shower nozzle (22), and hold it in this hole when first operating position, the latter is when second operating position, produce air-flow, this air-flow is granule medicament (12) tap (25), thereby above-mentioned granule medicament is discharged in the main body (14) of capsule (C).
2. capsule filler as claimed in claim 1 is characterized in that, is configured on the surface of shower nozzle (22) in the hole on the edge (25), with respect to the longitudinal axis (Z ') of shower nozzle (22) angle same separately.
3. capsule filler as claimed in claim 2 is characterized in that, the angle (α) between adjacent holes (25) equals 120 °.
4. as each described capsule filler among the claim 1-3, it is characterized in that, first rotating disk (2) has and is essentially funnel shaped cavity (19), this cavity is designed to when second operating position, can combine with shower nozzle (22), thereby help granule medicament (12) is sent into the main body (14) of capsule (C).
CNB038188864A 2002-08-08 2003-08-04 A capsule filling machine Expired - Fee Related CN100404014C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITBO2002A000525 2002-08-08
IT000525A ITBO20020525A1 (en) 2002-08-08 2002-08-08 OPERATING MACHINE.

Publications (2)

Publication Number Publication Date
CN1674854A true CN1674854A (en) 2005-09-28
CN100404014C CN100404014C (en) 2008-07-23

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CNB038188864A Expired - Fee Related CN100404014C (en) 2002-08-08 2003-08-04 A capsule filling machine

Country Status (12)

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US (1) US20060064943A1 (en)
EP (1) EP1553910B1 (en)
JP (1) JP2005535375A (en)
KR (1) KR20050027273A (en)
CN (1) CN100404014C (en)
AT (1) ATE391483T1 (en)
AU (1) AU2003250486A1 (en)
BR (1) BR0305676A (en)
DE (1) DE60320289T2 (en)
ES (1) ES2304540T3 (en)
IT (1) ITBO20020525A1 (en)
WO (1) WO2004014286A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1985789B (en) * 2005-12-23 2011-12-21 Mg2有限公司 Machine for metering microtablets
CN101134001B (en) * 2007-10-22 2012-09-19 湖南千山制药机械股份有限公司 Apparatus and method for filling tablets quantificationally into capsules
CN108025823A (en) * 2015-07-18 2018-05-11 德国翰辉包装机械有限责任公司 Method and apparatus for dividing and delivering pill

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EP3069708B1 (en) * 2011-10-06 2018-05-09 Combocap, Inc. Capsule
BR112015010601B1 (en) * 2012-11-09 2022-07-19 Civitas Therapeutics, Inc. PHARMACEUTICAL COMPOSITION AND USE OF THE COMPOSITION
US9456987B2 (en) 2013-04-03 2016-10-04 Binutra, Inc. Capsule with internal diaphragm
KR101391185B1 (en) * 2013-05-29 2014-05-27 주식회사 이수이엔지 Packing apparatus for stick typed pouch
US10071021B2 (en) * 2015-05-19 2018-09-11 Maxocap Corporation Capsule filling systems and methods of using a capsule filling system
ITUA20163077A1 (en) 2016-05-02 2017-11-02 Mg 2 Srl POWER SUPPLY GROUP FOR DETERMINATION OF GRANULES, IN PARTICULAR MICROGRANULES, IN CAPSULES
IT201900012504A1 (en) * 2019-07-22 2021-01-22 Ima Spa Machine and method for filling capsules.
CN113287778A (en) * 2021-05-31 2021-08-24 东莞市沃德精密机械有限公司 Vertical continuous filling device
US20240238162A1 (en) * 2021-08-27 2024-07-18 Multiply Labs Inc. System, method, and apparatus facilitating assembly of a capsule

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DE2050885C3 (en) * 1969-10-21 1974-02-28 Fratelli Zanasi S.P.A., Ozzano Emilia, Bologna (Italien) Process for dosing powdery substances with the aid of a plunger dosing device
CN2079506U (en) * 1990-11-23 1991-06-26 杨运禄 Semi-automatic filler for forming capsule
CN2237450Y (en) * 1995-07-18 1996-10-16 郑杰 Combied device for filling capsules
WO2001070171A1 (en) * 2000-03-22 2001-09-27 B.L. Macchine Automatiche Spa Capsules filling machine to pack powder, herbs, microgranules, pellets
US6363801B1 (en) * 2000-04-26 2002-04-02 General Electric Company Apparatus and process for selecting and positioning particles
DE10027008B4 (en) * 2000-05-31 2016-12-29 Robert Bosch Gmbh metering
US6357490B1 (en) * 2000-08-22 2002-03-19 Advanced Inhalation Research, Inc. System, method and apparatus for filling containers
US6745546B2 (en) * 2001-11-02 2004-06-08 R.P. Scherer Technologies, Inc. Encapsulation machine with valved injection wedge

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1985789B (en) * 2005-12-23 2011-12-21 Mg2有限公司 Machine for metering microtablets
CN101134001B (en) * 2007-10-22 2012-09-19 湖南千山制药机械股份有限公司 Apparatus and method for filling tablets quantificationally into capsules
CN108025823A (en) * 2015-07-18 2018-05-11 德国翰辉包装机械有限责任公司 Method and apparatus for dividing and delivering pill
US10556712B2 (en) 2015-07-18 2020-02-11 Harro Hoefliger Verpackungsmaschinen Gmbh Method and device for separating and transferring pellets

Also Published As

Publication number Publication date
ES2304540T3 (en) 2008-10-16
EP1553910B1 (en) 2008-04-09
DE60320289D1 (en) 2008-05-21
WO2004014286A1 (en) 2004-02-19
ATE391483T1 (en) 2008-04-15
JP2005535375A (en) 2005-11-24
US20060064943A1 (en) 2006-03-30
AU2003250486A1 (en) 2004-02-25
CN100404014C (en) 2008-07-23
DE60320289T2 (en) 2009-07-16
ITBO20020525A1 (en) 2004-02-09
KR20050027273A (en) 2005-03-18
BR0305676A (en) 2004-10-19
EP1553910A1 (en) 2005-07-20

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Granted publication date: 20080723