WO2004014286A1 - A capsule filling machine - Google Patents
A capsule filling machine Download PDFInfo
- Publication number
- WO2004014286A1 WO2004014286A1 PCT/IB2003/003566 IB0303566W WO2004014286A1 WO 2004014286 A1 WO2004014286 A1 WO 2004014286A1 IB 0303566 W IB0303566 W IB 0303566W WO 2004014286 A1 WO2004014286 A1 WO 2004014286A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- capsule
- operating position
- nozzle
- seats
- filling machine
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B35/00—Supplying, feeding, arranging or orientating articles to be packaged
- B65B35/06—Separating single articles from loose masses of articles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
- A61J3/074—Filling capsules; Related operations
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B37/00—Supplying or feeding fluent-solid, plastic, or liquid material, or loose masses of small articles, to be packaged
- B65B37/14—Supplying or feeding fluent-solid, plastic, or liquid material, or loose masses of small articles, to be packaged by pneumatic feeders
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B37/00—Supplying or feeding fluent-solid, plastic, or liquid material, or loose masses of small articles, to be packaged
- B65B37/16—Separating measured quantities from supply
Definitions
- the present invention relates to a capsule filling machine for the production of hard gelatin capsules containing pharmaceutical material.
- the pharmaceutical material in the hard gelatin capsules of the type with a capsule lid and a capsule body to which the present invention advantageously refers is in the form of particles, that is to say, micro-tablets or pellets.
- a capsule filling machine of the known type currently used basically comprises a central turret or carrousel rotating with discontinuous or stepping motion and equipped with a plurality of operating units located along the edge of the turret and driven by the turret by means of reciprocating drive parts.
- Each operating unit on the turret comprises a slide supporting element for holding one or more capsules to be carried to a plurality of work stations in which successive operating steps take place, in accordance with a known method. For example, closed capsule feed and angled positioning, subsequent opening of each capsule, that is to say, separation of the capsule body from the capsule lid, feeding a quantity of pharmaceutical material into the capsule body, then closing each capsule body with the relative capsule lid and, finally, discharge of the closed filled capsule obtained in this way.
- dosing units of known type each comprising a hollow punch which forms a cylinder and houses a piston (normally pneumatically driven) , pick up the pharmaceutical material by lowering the cylinder into a tank containing the material which is attached to the turret, together with an upward movement of the piston to allow dosing, that is to say, to allow the pharmaceutical material to be held in the cylinder previously immersed in the tank.
- the cylinder is then lifted out of the tank and, after a scraping or brushing step to remove any excess micro-tablets, the piston downstroke is activated to push the product, dosed according to the volume of the cylindrical chamber, into the capsule body, aligned in succession with the corresponding cylinder.
- the above-mentioned dosing units are used for efficient, precision dosing of pharmaceutical material in powder form, whilst if capsules are to be filled with particulate material such as micro-tablets or pellets, dosing is not as precise.
- the piston can pick up precise and constant volumes of powdered pharmaceutical material in the hollow cylinder, in the case of micro-tablets, the piston cannot exert sufficient pick up force on the micro-tablets to guarantee a given and constant number of micro-tablets which will then be released into each capsule body.
- the aim of the present invention is to produce a capsule filling machine which can overcome the above-mentioned disadvantage of the prior art.
- the aim of the present invention is to produce a capsule filling machine which guarantees high precision dosing.
- Another aim of the present invention is to propose a capsule filling machine which, together with the above-mentioned precision dosing, continues to guarantee the reliability, productivity and safety levels required of such machines, as well as the production speed typical of current capsule filling machine, in particular of high productivity continuous-motion capsule filling machines.
- the present invention provides a capsule filling machine for the production of hard gelatin capsules of the type with a capsule lid and a capsule body containing particles of pharmaceutical material, in particular micro-tablets or pellets, the machine comprising a first rotary carrousel, which supports a plurality of slide units for picking up and handling the capsules in order to open then close the capsules by separating then joining the capsule lids and the capsule bodies; a second carrousel, which rotates in such a way that it is synchronised with the first carousel, having a plurality of reciprocating doser means moving between a first operating position in which the doser means are designed to pick up pharmaceutical material from a tank containing the material which is attached to the machine and a second operating position in which they release the material into the capsule bodies.
- the machine is characterised in that the doser means each comprise a hollow nozzle with a plurality of seats on its edge for picking up and holding the particulate pharmaceutical material, each seat communicating with pneumatic means .
- the pneumatic means comprise pneumatic vacuum means which, in the first operating position, suck up and hold individual particles of the pharmaceutical material in respective seats of the nozzle, and pressurised pneumatic means which generate a flow that discharges the particles from the seats in the second operating position to allow the above-mentioned release of material into the capsule bodies.
- Figure 1 is a diagram illustrating the operating cycle of a capsule filling machine made according to the present invention
- Figures 2 and 3 are side views with some parts cut away and others in cross-section of a detail of the capsule filling machine made according to the present invention in two different operating configurations;
- Figure 4 is a front view with some parts in cross-section of a detail of a particular component of the capsule filling machine illustrated in Figures 2 and 3;
- Figure 5 is a cross-section of the component illustrated in Figure 4.
- FIG 6 is a detail of a part of the capsule filling machine illustrated in Figure 1.
- the capsule filling machine disclosed labelled 10 as a whole, is used for filling capsules C of the known type with a capsule lid and a capsule body, labelled 13 and 14 respectively, with given quantities of particles 12 of pharmaceutical material, specifically pharmaceutical micro-tables 12 or pellets.
- the capsule filling machine 10 comprises a first carrousel 2 rotating about a vertical axis Z in the direction indicated by the arrow L and having radial arms 2a, 2b supporting a plurality of slide units 3 for picking up capsule bodies 14 of capsules C and moving them in a horizontal direction, and a tank 11 with a known, substantially toroidal shape, located at the base of the capsule filling machine 10 and designed to hold a mass of micro-tablets 12 supplied from a feed hopper 30.
- the machine 10 also comprises a second carrousel 4 (Figure 2), also rotating about the vertical axis Z, again in the direction indicated by arrow L in Figure 1 and synchronised with the first rotary carrousel 2.
- the carrousel 4 is equipped with a plurality of micro-tablet 12 doser means 21.
- the doser means 21 are mobile in a vertical direction parallel with the axis Z alternatively between a first, pick up operating position ( Figures 2 and 6) , in which the means 21 are inside the tank 11 containing the micro-tablets 12 for picking up quantities consisting of a given number of individual micro-tablets 12 and, a second operating position for releasing the quantities of micro-tablets 12 into the capsule body 14 of a capsule C ( Figure 3) .
- the first rotary carrousel 2 picks up the capsules C from an upper hopper (of the known type and not illustrated) , containing the empty capsules C, then the capsules C are individually placed in the pick up means 3, each of the means comprising two bushings 15 and 17 for angling and guiding the capsules C.
- Each capsule C is handled in successive operating steps consisting of capsule C opening by separating the capsule lid 13 from the relative capsule body 14, filling the capsule body 14 with a quantity of micro-tablets 12 by means of the dosers 21, closing the capsule body 14 with the capsule lid 13 and, finally, discharge of the finished capsule C from the capsule filling machine 10 at an outfeed and unloading zone S ( Figure 1) .
- each of the doser means 21 comprises a cylindrical rod 20 with a free end 20a having a plurality of seats or openings 25 on the edge, for picking up and holding individual micro-tablets 12.
- Each of the openings 25 on the edge is also controlled by pneumatic means 24 ( Figure 2) , specifically pneumatic means 24a for generating a vacuum and pneumatic means 24b for generating a pressurised air jet.
- the means 24a are designed so that, in the first operating position, they pick up by suction a given number of micro-tablets 12 held in corresponding openings 25 on the edge, whilst the means 24b are designed so that, in the second operating position, they discharge and release the micro-tablets 12 into a capsule body 14 thanks to a pneumatic thrust coming out of the openings 25.
- each opening 25 preferably has dimensions corresponding to the dimensions of the micro-tablets 12 contained in the tank 11. In this way, positioning and holding the individual micro-tablet 12 at the opening 25 results in precision sealed closing of the opening 25.
- each opening 25 is preferably circular in shape, so that it forms a cylindrical cavity communicating with the pneumatic means 24 through pipes 27.
- V of the cylindrical rod 20 are arranged in two or more adjacent horizontal planes.
- the angular spaces separating the openings preferably have an angle of around 120° between one opening 25 on the edge and the next.
- the pneumatic means 24 also comprise a central channel 18, inside the cylindrical rod 20, for the circulation of air, whether pressurised or forming a vacuum, to the openings 25 on the edge by means of the pipes 27.
- the above-mentioned free pick up end 20a consists of a nozzle 22 with a tubular body whose central cylindrical cavity 23 has a constriction at the end, designed to form the central channel 18 for the passage of air forming a vacuum.
- the top of the nozzle 22 with the tubular body is, in turn, attached to a vertical hollow rod, forming the cylindrical rod 20, by a connecting zone 26.
- the hollow rod 20 is connected to selection valve means 50 controlling the pneumatic means 24.
- the selection valve means 50 are preferably located on the second carrousel 4 and connect the suction means 24a to the openings 25 in the first, pick up operating position illustrated in Figure 2, that is to say, with the nozzle 22 immersed in the mass of micro- tablets 12 contained in the tank 11 and, alternatively, switch to the connection between the openings 25 and the pressurised air means 24b, in the second operating position in which the micro-tablets 12 are released in to the capsule body 14 by pneumatic discharge of the micro-tablets 12.
- the arm 2a of the first carrousel 2 ( Figures 2 and 3) has a chamber 19 which is substantially funnel- shaped, designed to engage with the nozzle 22 in the second, release operating position, allowing and facilitating micro-tablet 12 infeed into the capsule body 14. Operation of the capsule filling machine 10 described so far can be easily inferred from the description above.
- the capsule filling machine 10 automatically performs all of the guided capsule C filling operations, according to the successive steps of opening, filling, closing and, finally, discharge from the machine 10.
- the filling step is performed by means of an operation whereby a predetermined number of micro-tablets 12 is picked up from the tank 11. This is done by lowering the hollow rod 20, equipped with the nozzle 22, into the mass of micro-tablets 12, then activating the suction means 24a designed to create a vacuum with a predetermined value, so that the nozzle 22 attracts and holds micro-tablets 12 at the openings 25.
- the rod 20 is then lifted in the known way to the position illustrated in Figure 3, and the bushing 17 with the capsule body 14 is moved horizontally to bring the capsule body precisely into position below the funnel-shaped chamber 19.
- the selection valve means 50 switch the hollow rod 20 connection from the suction means 24a to the pressurised air means 24b. This causes the release of each of the micro-tablets 12 held in the relative opening 25 into the funnel-shaped chamber 19 and, from here, into the capsule body 14 of the capsule C being filled.
- the bushing 17 supporting the capsule body 14 is again moved, to the position illustrated in Figure 2, continuing the rotary path illustrated in the diagram in Figure 1 with the upper bushing 15.
- the machine described above achieves the preset aims thanks to a simple feed nozzle structure which allows precise dosing of the number of micro-tablets to be inserted in the capsules.
- optimum dosing results were obtained with a number of openings 25 for each nozzle 22, and therefore, a number of micro- tablets 12, varying between thirteen and thirty.
- the precise and constant number of micro-tablets 12 which fills the capsule body 14 of each capsule C is precisely determined by the number of openings 25 in the nozzle 22, since a single micro-tablet 12 is held by suction in each opening 25.
- varying the number of openings in the pick up means varies the number, and therefore the dosage, of the micro-tablets.
- the dimensions of the openings may vary, as may the profile of the cavities formed by the openings in the nozzle body.
- the number of openings distributed in each plane and, therefore, their angular distribution may also vary.
- the pneumatic means for suction and pressurised air connected to the hollow rod may be of various types and powers, depending on the applications.
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/523,408 US20060064943A1 (en) | 2002-08-08 | 2003-08-04 | Capsule filling machine |
JP2004527220A JP2005535375A (en) | 2002-08-08 | 2003-08-04 | Capsule filling machine |
EP03784408A EP1553910B1 (en) | 2002-08-08 | 2003-08-04 | A capsule filling machine |
AU2003250486A AU2003250486A1 (en) | 2002-08-08 | 2003-08-04 | A capsule filling machine |
ES03784408T ES2304540T3 (en) | 2002-08-08 | 2003-08-04 | MACHINE TO FILL CAPSULES. |
BR0305676-7A BR0305676A (en) | 2002-08-08 | 2003-08-04 | Capsule Filling Machine |
DE60320289T DE60320289T2 (en) | 2002-08-08 | 2003-08-04 | capsule |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT000525A ITBO20020525A1 (en) | 2002-08-08 | 2002-08-08 | OPERATING MACHINE. |
ITBO2002A000525 | 2002-08-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2004014286A1 true WO2004014286A1 (en) | 2004-02-19 |
Family
ID=31503930
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2003/003566 WO2004014286A1 (en) | 2002-08-08 | 2003-08-04 | A capsule filling machine |
Country Status (12)
Country | Link |
---|---|
US (1) | US20060064943A1 (en) |
EP (1) | EP1553910B1 (en) |
JP (1) | JP2005535375A (en) |
KR (1) | KR20050027273A (en) |
CN (1) | CN100404014C (en) |
AT (1) | ATE391483T1 (en) |
AU (1) | AU2003250486A1 (en) |
BR (1) | BR0305676A (en) |
DE (1) | DE60320289T2 (en) |
ES (1) | ES2304540T3 (en) |
IT (1) | ITBO20020525A1 (en) |
WO (1) | WO2004014286A1 (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITBO20050791A1 (en) * | 2005-12-23 | 2007-06-24 | Mg 2 Srl | MACHINE FOR DOSING MICROCOMPRESSES |
CN101134001B (en) * | 2007-10-22 | 2012-09-19 | 湖南千山制药机械股份有限公司 | Apparatus and method for filling tablets quantificationally into capsules |
CN103987357B (en) | 2011-10-06 | 2017-12-12 | 康宝卡普股份有限公司 | The manufacturing method and apparatus of capsule |
BR112015010601B1 (en) | 2012-11-09 | 2022-07-19 | Civitas Therapeutics, Inc. | PHARMACEUTICAL COMPOSITION AND USE OF THE COMPOSITION |
US9456987B2 (en) | 2013-04-03 | 2016-10-04 | Binutra, Inc. | Capsule with internal diaphragm |
KR101391185B1 (en) * | 2013-05-29 | 2014-05-27 | 주식회사 이수이엔지 | Packing apparatus for stick typed pouch |
US10071021B2 (en) * | 2015-05-19 | 2018-09-11 | Maxocap Corporation | Capsule filling systems and methods of using a capsule filling system |
CN108025823B (en) * | 2015-07-18 | 2019-12-27 | 德国翰辉包装机械有限责任公司 | Method and apparatus for dividing and delivering pills |
ITUA20163077A1 (en) | 2016-05-02 | 2017-11-02 | Mg 2 Srl | POWER SUPPLY GROUP FOR DETERMINATION OF GRANULES, IN PARTICULAR MICROGRANULES, IN CAPSULES |
IT201900012504A1 (en) | 2019-07-22 | 2021-01-22 | Ima Spa | Machine and method for filling capsules. |
CN113287778A (en) * | 2021-05-31 | 2021-08-24 | 东莞市沃德精密机械有限公司 | Vertical continuous filling device |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2050885A1 (en) * | 1969-10-21 | 1971-04-29 | Fratelh Zanasi SpA, Ozzano Emilia, Bologna (Italien) | Syphon dosimeter for pharmaceutical powders |
WO2001070171A1 (en) * | 2000-03-22 | 2001-09-27 | B.L. Macchine Automatiche Spa | Capsules filling machine to pack powder, herbs, microgranules, pellets |
US20020002809A1 (en) * | 2000-05-31 | 2002-01-10 | Robert Bosch Gmbh | Metering device |
US6363801B1 (en) * | 2000-04-26 | 2002-04-02 | General Electric Company | Apparatus and process for selecting and positioning particles |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN2079506U (en) * | 1990-11-23 | 1991-06-26 | 杨运禄 | Semi-automatic filler for forming capsule |
CN2237450Y (en) * | 1995-07-18 | 1996-10-16 | 郑杰 | Combied device for filling capsules |
US6357490B1 (en) * | 2000-08-22 | 2002-03-19 | Advanced Inhalation Research, Inc. | System, method and apparatus for filling containers |
US6745546B2 (en) * | 2001-11-02 | 2004-06-08 | R.P. Scherer Technologies, Inc. | Encapsulation machine with valved injection wedge |
-
2002
- 2002-08-08 IT IT000525A patent/ITBO20020525A1/en unknown
-
2003
- 2003-08-04 ES ES03784408T patent/ES2304540T3/en not_active Expired - Lifetime
- 2003-08-04 AT AT03784408T patent/ATE391483T1/en not_active IP Right Cessation
- 2003-08-04 JP JP2004527220A patent/JP2005535375A/en active Pending
- 2003-08-04 BR BR0305676-7A patent/BR0305676A/en not_active IP Right Cessation
- 2003-08-04 US US10/523,408 patent/US20060064943A1/en not_active Abandoned
- 2003-08-04 KR KR1020057001841A patent/KR20050027273A/en not_active Application Discontinuation
- 2003-08-04 AU AU2003250486A patent/AU2003250486A1/en not_active Abandoned
- 2003-08-04 EP EP03784408A patent/EP1553910B1/en not_active Expired - Lifetime
- 2003-08-04 CN CNB038188864A patent/CN100404014C/en not_active Expired - Fee Related
- 2003-08-04 DE DE60320289T patent/DE60320289T2/en not_active Expired - Fee Related
- 2003-08-04 WO PCT/IB2003/003566 patent/WO2004014286A1/en active IP Right Grant
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2050885A1 (en) * | 1969-10-21 | 1971-04-29 | Fratelh Zanasi SpA, Ozzano Emilia, Bologna (Italien) | Syphon dosimeter for pharmaceutical powders |
WO2001070171A1 (en) * | 2000-03-22 | 2001-09-27 | B.L. Macchine Automatiche Spa | Capsules filling machine to pack powder, herbs, microgranules, pellets |
US6363801B1 (en) * | 2000-04-26 | 2002-04-02 | General Electric Company | Apparatus and process for selecting and positioning particles |
US20020002809A1 (en) * | 2000-05-31 | 2002-01-10 | Robert Bosch Gmbh | Metering device |
Also Published As
Publication number | Publication date |
---|---|
BR0305676A (en) | 2004-10-19 |
AU2003250486A1 (en) | 2004-02-25 |
DE60320289T2 (en) | 2009-07-16 |
CN1674854A (en) | 2005-09-28 |
US20060064943A1 (en) | 2006-03-30 |
ITBO20020525A1 (en) | 2004-02-09 |
JP2005535375A (en) | 2005-11-24 |
DE60320289D1 (en) | 2008-05-21 |
ES2304540T3 (en) | 2008-10-16 |
CN100404014C (en) | 2008-07-23 |
KR20050027273A (en) | 2005-03-18 |
EP1553910B1 (en) | 2008-04-09 |
EP1553910A1 (en) | 2005-07-20 |
ATE391483T1 (en) | 2008-04-15 |
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