CN1669551A - 一种滴丸基质辅料及其滴丸制备方法 - Google Patents
一种滴丸基质辅料及其滴丸制备方法 Download PDFInfo
- Publication number
- CN1669551A CN1669551A CN 200410018761 CN200410018761A CN1669551A CN 1669551 A CN1669551 A CN 1669551A CN 200410018761 CN200410018761 CN 200410018761 CN 200410018761 A CN200410018761 A CN 200410018761A CN 1669551 A CN1669551 A CN 1669551A
- Authority
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- Prior art keywords
- drop pill
- adjuvant
- substrate
- substrate adjuvant
- melting point
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000006187 pill Substances 0.000 title claims abstract description 137
- 239000000463 material Substances 0.000 title abstract description 9
- 238000004519 manufacturing process Methods 0.000 title abstract description 3
- -1 sucrose ester Chemical class 0.000 claims abstract description 96
- 239000002671 adjuvant Substances 0.000 claims abstract description 82
- 229930006000 Sucrose Natural products 0.000 claims abstract description 51
- 239000005720 sucrose Substances 0.000 claims abstract description 51
- 238000002844 melting Methods 0.000 claims abstract description 25
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 9
- 239000008101 lactose Substances 0.000 claims abstract description 9
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 claims abstract description 6
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims abstract description 5
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims abstract description 5
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000000811 xylitol Substances 0.000 claims abstract description 5
- 235000010447 xylitol Nutrition 0.000 claims abstract description 5
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract description 5
- 229960002675 xylitol Drugs 0.000 claims abstract description 5
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims abstract description 3
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims abstract description 3
- 239000000758 substrate Substances 0.000 claims description 74
- 229940008099 dimethicone Drugs 0.000 claims description 44
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 44
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 44
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 44
- 239000007788 liquid Substances 0.000 claims description 34
- 239000002826 coolant Substances 0.000 claims description 31
- 239000003814 drug Substances 0.000 claims description 31
- 238000010438 heat treatment Methods 0.000 claims description 28
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 26
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 26
- 239000003292 glue Substances 0.000 claims description 26
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 26
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 26
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 25
- 230000008018 melting Effects 0.000 claims description 24
- 239000000203 mixture Substances 0.000 claims description 23
- 230000004927 fusion Effects 0.000 claims description 22
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 18
- 238000002156 mixing Methods 0.000 claims description 17
- 239000000377 silicon dioxide Substances 0.000 claims description 13
- 238000002360 preparation method Methods 0.000 claims description 12
- 235000012239 silicon dioxide Nutrition 0.000 claims description 12
- 238000009472 formulation Methods 0.000 claims description 11
- 229940075507 glyceryl monostearate Drugs 0.000 claims description 9
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims description 9
- 229920002472 Starch Polymers 0.000 claims description 7
- 239000008107 starch Substances 0.000 claims description 7
- 235000019698 starch Nutrition 0.000 claims description 7
- 241001597008 Nomeidae Species 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims description 4
- 229940057995 liquid paraffin Drugs 0.000 claims description 3
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- 238000004140 cleaning Methods 0.000 claims description 2
- 239000004014 plasticizer Substances 0.000 claims description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 2
- 239000008158 vegetable oil Substances 0.000 claims description 2
- 239000000832 lactitol Substances 0.000 abstract 1
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 abstract 1
- 235000010448 lactitol Nutrition 0.000 abstract 1
- 229960003451 lactitol Drugs 0.000 abstract 1
- 229960001375 lactose Drugs 0.000 abstract 1
- 229960004793 sucrose Drugs 0.000 abstract 1
- 229960003487 xylose Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 description 27
- 238000003756 stirring Methods 0.000 description 21
- 238000001035 drying Methods 0.000 description 20
- 239000004744 fabric Substances 0.000 description 20
- 238000009413 insulation Methods 0.000 description 20
- 239000002932 luster Substances 0.000 description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 20
- 239000000155 melt Substances 0.000 description 17
- 235000013305 food Nutrition 0.000 description 14
- 229940079593 drug Drugs 0.000 description 9
- 239000000284 extract Substances 0.000 description 8
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 239000002202 Polyethylene glycol Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 229920001223 polyethylene glycol Polymers 0.000 description 6
- 241000180649 Panax notoginseng Species 0.000 description 5
- 235000003143 Panax notoginseng Nutrition 0.000 description 5
- 238000011161 development Methods 0.000 description 4
- 230000018109 developmental process Effects 0.000 description 4
- 239000000341 volatile oil Substances 0.000 description 4
- 108010010803 Gelatin Proteins 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 3
- 239000012141 concentrate Substances 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 239000008273 gelatin Substances 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 235000011852 gelatine desserts Nutrition 0.000 description 3
- 229920001983 poloxamer Polymers 0.000 description 3
- 229960000502 poloxamer Drugs 0.000 description 3
- 229920000570 polyether Polymers 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000003809 water extraction Methods 0.000 description 3
- NQBWNECTZUOWID-UHFFFAOYSA-N (E)-cinnamyl (E)-cinnamate Natural products C=1C=CC=CC=1C=CC(=O)OCC=CC1=CC=CC=C1 NQBWNECTZUOWID-UHFFFAOYSA-N 0.000 description 2
- 241000237903 Hirudo Species 0.000 description 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 2
- 241001643642 Viticis Species 0.000 description 2
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 2
- NQBWNECTZUOWID-QSYVVUFSSA-N cinnamyl cinnamate Chemical compound C=1C=CC=CC=1\C=C/C(=O)OC\C=C\C1=CC=CC=C1 NQBWNECTZUOWID-QSYVVUFSSA-N 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 239000012259 ether extract Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 229930003944 flavone Natural products 0.000 description 2
- 150000002212 flavone derivatives Chemical class 0.000 description 2
- 235000011949 flavones Nutrition 0.000 description 2
- 238000011068 loading method Methods 0.000 description 2
- 239000012567 medical material Substances 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000000194 supercritical-fluid extraction Methods 0.000 description 2
- 229920002994 synthetic fiber Polymers 0.000 description 2
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 2
- JECYNCQXXKQDJN-UHFFFAOYSA-N 2-(2-methylhexan-2-yloxymethyl)oxirane Chemical compound CCCCC(C)(C)OCC1CO1 JECYNCQXXKQDJN-UHFFFAOYSA-N 0.000 description 1
- 241000208340 Araliaceae Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 235000011201 Ginkgo Nutrition 0.000 description 1
- 244000194101 Ginkgo biloba Species 0.000 description 1
- 235000008100 Ginkgo biloba Nutrition 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- RXUWDKBZZLIASQ-UHFFFAOYSA-N Puerarin Natural products OCC1OC(Oc2c(O)cc(O)c3C(=O)C(=COc23)c4ccc(O)cc4)C(O)C(O)C1O RXUWDKBZZLIASQ-UHFFFAOYSA-N 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- IYNDLOXRXUOGIU-LQDWTQKMSA-M benzylpenicillin potassium Chemical compound [K+].N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)CC1=CC=CC=C1 IYNDLOXRXUOGIU-LQDWTQKMSA-M 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
- 229960000520 diphenhydramine Drugs 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 238000002481 ethanol extraction Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000012395 formulation development Methods 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 150000002333 glycines Chemical class 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 description 1
- 208000030194 mouth disease Diseases 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- HKEAFJYKMMKDOR-VPRICQMDSA-N puerarin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1C1=C(O)C=CC(C2=O)=C1OC=C2C1=CC=C(O)C=C1 HKEAFJYKMMKDOR-VPRICQMDSA-N 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
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- 238000003860 storage Methods 0.000 description 1
- 125000000185 sucrose group Chemical group 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 206010048282 zoonosis Diseases 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims (17)
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/563,078 US20070059358A1 (en) | 2003-07-02 | 2004-02-07 | Matrix adjuvants and the drop pills prepared with them |
CN200410018761A CN100592920C (zh) | 2004-03-17 | 2004-03-17 | 一种滴丸基质辅料及其滴丸制备方法 |
JP2006517936A JP5401013B2 (ja) | 2003-07-02 | 2004-07-02 | マトリクスアジュバントおよびそれらとともに調製される滴丸 |
AU2004253211A AU2004253211B2 (en) | 2003-07-02 | 2004-07-02 | Matrix adjuvants and the drop pills prepared with them |
KR1020127025875A KR20120118082A (ko) | 2003-07-02 | 2004-07-02 | 기질 보강제 및 이들에 의해 제조된 점적 환제 |
PCT/CN2004/000730 WO2005002547A1 (fr) | 2003-07-02 | 2004-07-02 | Adjuvants de matrice et granules preparees a l'aide desdits adjuvants |
EP04738328.6A EP1647269B1 (en) | 2003-07-02 | 2004-07-02 | Matrix adjuvants and the drop pills prepared with them |
KR1020057025485A KR101298256B1 (ko) | 2003-07-02 | 2004-07-02 | 기질 보강제 및 이들에 의해 제조된 점적 환제 |
RU2005141403/15A RU2354403C2 (ru) | 2003-07-02 | 2004-07-02 | Связующее вспомогательное вещество и приготовленная на его основе таблетка в форме капли |
BRPI0411626-7A BRPI0411626A (pt) | 2003-07-02 | 2004-07-02 | adjuvantes de matrizes e pìlulas de deposição com eles preparadas |
CA2530783A CA2530783C (en) | 2003-07-02 | 2004-07-02 | Drop pills prepared from excipients derived from natural sources |
AU2009251014A AU2009251014B2 (en) | 2003-07-02 | 2009-12-17 | Matrix adjuvants and the drop pills prepared with them |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200410018761A CN100592920C (zh) | 2004-03-17 | 2004-03-17 | 一种滴丸基质辅料及其滴丸制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1669551A true CN1669551A (zh) | 2005-09-21 |
CN100592920C CN100592920C (zh) | 2010-03-03 |
Family
ID=35041128
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200410018761A Expired - Fee Related CN100592920C (zh) | 2003-07-02 | 2004-03-17 | 一种滴丸基质辅料及其滴丸制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN100592920C (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101780116A (zh) * | 2010-03-19 | 2010-07-21 | 上海应用技术学院 | 一种食品级基质的中药浸膏滴丸及其制备方法 |
CN101194907B (zh) * | 2006-12-08 | 2011-08-10 | 天津天士力制药股份有限公司 | 一种含那可丁的滴丸及其制备方法 |
CN101194904B (zh) * | 2006-12-08 | 2011-08-10 | 天津天士力制药股份有限公司 | 一种含马来酸哌克昔林的滴丸及其制备方法 |
CN113133976A (zh) * | 2020-01-19 | 2021-07-20 | 成都百裕制药股份有限公司 | 一种有效成分包含银杏萜内酯的滴丸 |
-
2004
- 2004-03-17 CN CN200410018761A patent/CN100592920C/zh not_active Expired - Fee Related
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101194907B (zh) * | 2006-12-08 | 2011-08-10 | 天津天士力制药股份有限公司 | 一种含那可丁的滴丸及其制备方法 |
CN101194904B (zh) * | 2006-12-08 | 2011-08-10 | 天津天士力制药股份有限公司 | 一种含马来酸哌克昔林的滴丸及其制备方法 |
CN101780116A (zh) * | 2010-03-19 | 2010-07-21 | 上海应用技术学院 | 一种食品级基质的中药浸膏滴丸及其制备方法 |
CN101780116B (zh) * | 2010-03-19 | 2012-05-09 | 上海应用技术学院 | 一种食品级基质的中药浸膏滴丸及其制备方法 |
CN113133976A (zh) * | 2020-01-19 | 2021-07-20 | 成都百裕制药股份有限公司 | 一种有效成分包含银杏萜内酯的滴丸 |
CN113133976B (zh) * | 2020-01-19 | 2022-03-04 | 成都百裕制药股份有限公司 | 一种有效成分包含银杏萜内酯的滴丸 |
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Publication number | Publication date |
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CN100592920C (zh) | 2010-03-03 |
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Owner name: TASLY PHARMACEUTICAL GROUP CO., LTD. Free format text: FORMER NAME: TIANJIN TASLY PHARMACEUTICAL CO., LTD. |
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Address after: 300402 Tianjin City, Beichen science and Technology Park of Beichen Xinyi Road Liaohe Road No. 1 white Patentee after: Tasly Pharmaceutical Group Co., Ltd. Address before: 300402 Tianjin City, Beichen science and Technology Park of Beichen Xinyi Road Liaohe Road No. 1 white Patentee before: Tianjin Tianshili Pharmaceutical Co., Ltd. |
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CP01 | Change in the name or title of a patent holder | ||
CP01 | Change in the name or title of a patent holder |
Address after: 300402 Tianjin City, Beichen science and Technology Park of Beichen Xinyi Road Liaohe Road No. 1 white Patentee after: Tasly Pharmaceutical Group Limited by Share Ltd Address before: 300402 Tianjin City, Beichen science and Technology Park of Beichen Xinyi Road Liaohe Road No. 1 white Patentee before: Tasly Pharmaceutical Group Co., Ltd. |
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CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20100303 Termination date: 20210317 |