CN1660398B - Combination of medication for treating sleep disorder - Google Patents
Combination of medication for treating sleep disorder Download PDFInfo
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- CN1660398B CN1660398B CN 200410093437 CN200410093437A CN1660398B CN 1660398 B CN1660398 B CN 1660398B CN 200410093437 CN200410093437 CN 200410093437 CN 200410093437 A CN200410093437 A CN 200410093437A CN 1660398 B CN1660398 B CN 1660398B
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- insomnia
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Abstract
A Chinese medicine for treating insomnia is prepared from 6 Chinese-medicinal materials including ganoderma, tuckahoe, fleece flower root, wild jupube kernel, etc.
Description
Technical field
The present invention relates to the Chinese medicine pharmaceutical composition, specifically a kind of oral Chinese medicine pharmaceutical composition of Cure for insomnia.
Background technology
At present, the medicine of Cure for insomnia is numerous, and certain curative effect is respectively arranged.The situation of insomnia is varied, causes that the factor of insomnia is also a lot.Particularly in 21 century, numerous social factors such as competition of the rhythm of life, the pressure of work, the talent make many people suffer from the insomnia that weight differs.Therefore, must suit the remedy to the case, treating both the principal and secondary aspects of a disease just can prove effective.Though the Chinese patent medicine kind of existing Cure for insomnia is many, its curative effect is people's will not all to the greatest extent.
Summary of the invention
To the objective of the invention is in order addressing the above problem, a kind of Chinese patent medicine of new Cure for insomnia to be provided, the dosage form of its prescription and selection has very strong specific aim to Cure for insomnia, and it is low to have a cost of taking medicine, and the cycle is short, and is evident in efficacy, characteristics such as cure rate height.
Purpose of the present invention can take following method to realize:
The pharmaceutical composition of a kind of oral medication insomnia, it is characterized in that it by following main materials be component form or by the water extract of following main materials as active component with pharmaceutically acceptable additives are formed or be made up of as active component and pharmaceutically acceptable additives the alcohol extract of following main materials:
BULBUS LILII 2-5 weight portion, Ganoderma 5-8 weight portion, Poria 1-2 weight portion, Radix Polygoni Multiflori 1-2 weight portion, Semen Ziziphi Spinosae 1 weight portion, Radix Polygalae 1 weight portion.
Purpose of the present invention can also take following method to realize:
Its formula optimization is: BULBUS LILII 3 weight portions, Ganoderma 3 weight portions, Poria 2 weight portions, Radix Polygoni Multiflori 2 weight portions, Semen Ziziphi Spinosae 1 weight portion, Radix Polygalae 1 weight portion.
Described pharmaceutically acceptable additives are following one or more: glycerol, gelatin, lecithin, sodium lauryl sulphate, dimethyl sulfoxine, azone, Polyethylene Glycol, Polyethylene Glycol-32, glycerol monolaurate (gelucire44/14), HPMC, CMC-Na, ethylparaben, tartaric acid, citric acid, sodium bicarbonate, propylene glycol, carbomer, PVA, alginate, tragcanth, dextrin, dried starch etc.
Its dosage form can be a said dosage form on any pharmaceutics, and as syrup, oral liquid, dissolved granule, tablet, capsule: described capsule can be common capsule, effervescent capsule or other various suitable capsules.Described tablet can be common tablet, effervescent tablet, dispersible tablet or other various suitable tablets, can be with suitable coating material coating also coating not, preferred syrup.
The present invention is the compound preparation energy tranquilizing by nourishing the heart that active component is made with BULBUS LILII, Ganoderma, Poria, Radix Polygoni Multiflori, Semen Ziziphi Spinosae and Radix Polygalae, nourishing YIN and moistening the lung, relieving restlessness clears away heart-fire, can treat various insomnias, its medicine time is short, no dependence, curative effect is obvious, the cure rate height, Cure for insomnia disease is with strong points, and sphere of action is extensive.
The specific embodiment
Describe implementation of the present invention in detail below in conjunction with embodiment.
Embodiment 1:
The preparation of syrup
Get BULBUS LILII 300 gram, Ganoderma 300 grams, Poria 200 grams, Radix Polygoni Multiflori 200 grams, Semen Ziziphi Spinosae 100 grams part, Radix Polygalae 100 grams, decoct with water secondary, 3 hours for the first time, 2 hours for the second time, collecting decoction filtered, and filtrate is concentrated in right amount.Other gets sucrose and adds water boil in right amount, after the dissolving, concentrates and to make syrup, with above-mentioned concentrated solution mixing, boils, and puts coldly, adds an amount of antiseptic and essence, and is diluted to certain volume promptly with cold boiled water.This product is tan thick liquid, and it is sweet to distinguish the flavor of.Relative density is 1.26-1.28.
Embodiment 2:
The preparation of oral liquid
Get BULBUS LILII 500 gram, Ganoderma 800 grams, Poria 200 grams, Radix Polygoni Multiflori 200 grams, Semen Ziziphi Spinosae 100 grams part, Radix Polygalae 100 grams, decoct with water secondary, 3 hours for the first time, 2 hours for the second time, collecting decoction, filter, filtrate is concentrated into an amount of volume, puts coldly, adds 95% ethanol of 3 times of amounts of medicinal liquid, stir evenly, leave standstill filtration after 24 hours.Be evaporated to the thick paste shape, add water and diluted cold preservation in right amount 24 hours, filter, add 300 milliliters of simple syrups, sodium benzoate 5 grams, add water to 1000 milliliters again, stir evenly, cold preservation filters, and embedding is sterilized 30 minutes promptly for 100 ℃ in 10 milliliters of ampoules.
In like manner, the present invention makes up material agent, capsule or the tablet that production technology routinely also can be made into Cure for insomnia disease with said medicine and medicinal additive.
Application examples 1:
By following clinical 206 routine insomniacs' treatment and observation, this preparation clinical cure rate is 61%.Specifically see Table 1, table 2.Matched group is an ANSHEN BUNAO YE, and of the present invention group is the syrup of embodiment 1 preparation.30 days time cycles were a course of treatment.
Two kinds of method Cure for insomnias of table 1 crux fruit
Two kinds of method Cure for insomnias of table 2 crux fruit
Look into subordinate list X
2Value show X
2 0.05(1)=3.841 X
2 0.01(1)=6.635
This example is calculated X
2 0.01=7.72＞6.635 P＜of the present invention group of therapeutic effect of 0.01 explanation has highly significant.By inquiry, wherein 50 routine effects do not show, and its main cause is due to patient heavy drinking and work during medication are overworked.Then, also prohibit against alcoholic drinks or take a good rest continuation one course of treatment of medication, and insomnia improves substantially, obtained satisfied result.
Claims (4)
1. the pharmaceutical composition of oral medication insomnia, it is characterized in that: it makes active component by the water extract of following raw materials according and pharmaceutically receptible additives are formed, and the weight portion of each raw material is:
BULBUS LILII 2-5 weight portion, Ganoderma 5-8 weight portion, Poria 1-2 weight portion, Radix Polygoni Multiflori 1-2 weight portion, Semen Ziziphi Spinosae 1 weight portion and Radix Polygalae 1 weight portion.
2. the pharmaceutical composition of oral medication insomnia, it is characterized in that: it makes active component by the water extract of following raw materials according and pharmaceutically receptible additives are formed, and the weight portion of each raw material is:
BULBUS LILII 3 weight portions, Ganoderma 3 weight portions, Poria 2 weight portions, Radix Polygoni Multiflori 2 weight portions, Semen Ziziphi Spinosae 1 weight portion and Radix Polygalae 1 weight portion.
3. the pharmaceutical composition of a kind of oral medication insomnia according to claim 1 is characterized in that: described pharmaceutically receptible additives are following more than one: glycerol, gelatin, lecithin, tartaric acid, citric acid, sodium bicarbonate.
4. the pharmaceutical composition of a kind of oral medication insomnia according to claim 1, it is characterized in that: its dosage form is syrup or oral liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410093437 CN1660398B (en) | 2004-12-23 | 2004-12-23 | Combination of medication for treating sleep disorder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410093437 CN1660398B (en) | 2004-12-23 | 2004-12-23 | Combination of medication for treating sleep disorder |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1660398A CN1660398A (en) | 2005-08-31 |
| CN1660398B true CN1660398B (en) | 2011-02-16 |
Family
ID=35010135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410093437 Expired - Fee Related CN1660398B (en) | 2004-12-23 | 2004-12-23 | Combination of medication for treating sleep disorder |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1660398B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101919962B (en) * | 2009-06-10 | 2012-01-25 | 河北以岭医药研究院有限公司 | Medicine for curing insomnia and preparation method thereof |
| CN102716360A (en) * | 2012-06-20 | 2012-10-10 | 李良 | Cortex albiziae Chinese medicine decoction for relieving insomnia and preparation method |
| CN103463473B (en) * | 2013-08-15 | 2015-05-06 | 怀宁县华春医院 | Traditional Chinese medicine for treating intractable insomnia, |
| CN103622017B (en) * | 2013-11-28 | 2016-04-06 | 潘新华 | Glossy ganoderma cordycepin particle |
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2004
- 2004-12-23 CN CN 200410093437 patent/CN1660398B/en not_active Expired - Fee Related
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| Publication number | Publication date |
|---|---|
| CN1660398A (en) | 2005-08-31 |
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|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110216 Termination date: 20131223 |