CN1618462A - Compositions of SOD and vetetative medicine or its extractives, and its prepn. method - Google Patents

Abstract

A composition of SOD and vegetative medicine or its extract for increasing the power to resist against anoxia and fatigue and the endurance of sports, and its preparing process are disclosed. Its advantages are high concentration, antioxidizing activity and skin or mucosa absorptivity, and long half-life period.

Description

The composition and method of making the same of SOD and plant amedica or its extract

Affiliated field

The present invention relates to the composition and method of making the same of superoxide dismutase SOD and plant amedica, particularly SOD and plant amedica or its extract.Be to utilize both complementary functions, eliminate unnecessary superoxide anion free radical and hydroxy radical in the body, stabilizing cell membrane and antienzyme activity are used for disease prevention or treatment, and resisting fatigue, raising immunity, can satisfy the needs of human health longevity.

Background technology

SOD is a kind of compound enzyme, and there is super hydrogen oxide enzyme the status in the human defensive system, goes back glutathione, and oxidized form of glutathione contains selenic glutathion superoxides enzyme; Human experimentation shows that SOD content is 90mg/L in the normal human blood, and the superoxides enzyme is 9mg/L, so the sweet peptidyl transferase of Guang is 1mg/L, visible SOD is to the importance of human body.Therefore three enzymes are compared, and SOD is undoubtedly the key enzyme in the defense system.Oxygen relies on the catalytic action of cytochrome oxidase, and the absorption oxygen of 98%-99% can directly be reduced to H ₂O, but remaining O ₂Be reduced to O by single electron ^- ₂SOD is catalysis superoxide radical (O in the aerobe object ^- ₂Or HO ₂) disproportionation is H ₂O ₂With O ₂A kind of metalloenzyme, difference along with metal species is divided into CuZn-SOD, Mn-SOD, Fe-SOD and Ni-SOD, all belong to acidic protein, 26S Proteasome Structure and Function is more stable, can tolerate the effect of various physics or chemical factor, to the stability of heat, PH and proteolytic enzyme than higher, usually in the PH5.3-9.5 scope, SOD catalytic reaction speed is unaffected, keeps the interior ultra-large type oxygen-derived free radicals of cell and is in harmless low-level state.As a kind of functional component, the physiological function of SOD can be summarized as: remove and produce excessive ultra-oxygen anion free radical in the body metabolic process, delay owing to free radical is encroached on the aging phenomenon that occurs, as delaying decrepitude of skin and the sedimentary appearance of lipofuscin; Improve the resistance of human body, comprise tumor, inflammation, emphysema, cataract and autoimmune disease etc. inducing an illness owing to the free radical infringement; Improve the resistance of human body to the extraneous incitant of free radical, as smog, radiation, toxic chemical and poisonous pharmaceuticals etc., enhancing body is the adaptive faculty of environment to external world; Pain and the serious adverse of ameliorate tumor patient when carrying out chemotherapy, radiotherapy is as bone marrow injury and leukopenia etc.; Eliminate organism fatigue, strengthen adaptive faculty the over loading large amount of exercise.In vivo, zinc is the constituent of many enzymes, can influence the structure of organic minute ligand of some non-enzyme again, participates in the metabolism of interior various materials of body and energy, thereby demonstrates the physiological function that it has: be the constituent of multiple metalloenzyme in the body; Protection stabilate film; Promote the growth promoter and the tissue regeneration of body; Regulate immunologic function; Influence hormonal system; Improve the sense of taste and promote appetite; Promote the homergy and the visual performance of vitamin A; The normal function of protection skin and skeleton; Promote intelligence development.

The principal element that influences the SOD clinical practice has: biological half-life; The foreign protein immunogenicity; The permeability of cell membrane and stability.After this showed that modification SOD enters the body circulation, it was slack-off to eliminate speed, but distribution speed is still very fast; Compare with free SOD, modification SOD is the content height in liver and kidney, and content is also higher in brain; The free distribution sequence trend of SOD in tissue is stomach, intestinal, muscle, lung, brain, liver, brain, kidney, spleen, the heart and testis, the result proves that variation has taken place modification enzyme's metabolic pathway, this and enzyme cell membrane permeability-related, content during the modification enzyme organizes in brain is higher, illustrate that the modification enzyme can pass through blood brain barrier, this is significant for the treatment cerebral trauma.Mainly concentrate on radioprotective at present both at home and abroad, antitumor, on defying age and the autoimmune disease, the disease kind of treatment has: ischemic reperfusion syndrome, oxygen intoxication, radiation damage, dermatosis, osteoarthritis, rheumatoid arthritis, burn, senile cataract, familial muscular dystrophy etc., because the SOD that uses is heterologous protein at present, and molecular weight is all greater than 30000, therefore human body is the problem of very paying close attention in the application to its toleration, illustrate that SOD has no side effect, the people has stronger tolerance to it; Reorganization SOD is the very little biomacromolecule of toxicity and side effect, but as antigen, repeatedly injects in the body and still can bring out immunoreation, so optimal method is the SOD with sod gene clone and expressing human; Perhaps nanorize makes the macromole peptide become little peptide, is beneficial to absorption of human body, and this all is our settled problem.

Traditional Chinese herbal medicine is medical to be single less, mostly be compound recipe, being particular about monarch, is the main treatment disease with one, two flavor monarchs drug often, but because Chinese herbal medicine composition complexity, except that active ingredient, also have a large amount of impurity, even harmful material, have side effects, so that poison, need other ministerial drug assistants to make and eliminate the effects of the act, help to absorb, thereby the prescription volume is excessive, unfavorable use, also existence disappears, and this answers that toxic and side effects, and cancels out each other, and reduces drug effect, be difficult to bring into play the real effect of principal agent, demand urgently improving.

Summary of the invention

The present invention is directed to the prior art deficiency, utilize modern biochemical technology and Chinese medicine and pharmacy theory, the composition and method of making the same of a kind of SOD and plant amedica or its extract is provided, it is the compositions use in conjunction of SOD and plant amedica or its extract, improve drug level and active ingredient, antioxidant activity improves more than 6 times, and skin, mucosa absorption rate reach more than 90%, and the half-life prolongs two more than the order of magnitude; Can enter directly to bring into play in the cell and remove free radical, have the effect of stronger anti peroxidation of lipid, the comprehensive drug performance is more thorough, it is comparable to be far from traditional herbal mixture, is used to improve anti-anoxia ability, the performance anti-fatigue effect, improving exercise tolerance, is the big invention to human medicinal career.

The compositions of SOD and plant amedica or its extract, its proportioning is: SOD 1000-1 ten thousand active units: plant amedica 1-50 gram.

The preparation method of composition of SOD and plant amedica or its extract is to add in the SOD plant amedica or its extract.

Plant amedica can be food be again the plant of medicine, as Semen Ziziphi Spinosae, Fructus Gardeniae, CitrusaurantiumL.Var.amara Engl., Fructus Momordicae, Cortex Cinnamomi, Semen Raphani, Pericarpium Citri Reticulatae, Fructus Amomi, Fructus Mume, Semen Myristicae, the Radix Angelicae Dahuricae, Flos Chrysanthemi, Herba Pogostemonis, Fructus Hippophae, Semen Pruni, Fructus Canarii, Bulbus Allii Macrostemonis, Herba Menthae, Flos Caryophylli, Rhizoma Alpiniae Officinarum, Semen Ginkgo, Fructus Citri, Fructus Cannabis, orange, Poria, Herba Moslae, Folium Perillae, Fructus Anisi Stellati, Semen Canavaliae, Rhizoma Zingiberis Recens, Fructus Jujubae, Rhizoma Dioscoreae, Fructus Crataegi, Fructus Foeniculi, SENGUA, Arillus Longan, Semen Lablab Album, Bulbus Lilii, Pericarpium Zanthoxyli, Semen Euryales, Semen Phaseoli, Fructus Citri Sarcodactylis, Caulis et Folium Lactucae sativae, Semen Armeniacae Amarum, Thallus Laminariae (Thallus Eckloniae), Semen Persicae, Semen Nelumbinis, Fructus Mori, Herba Cichorii, Semen Sojae Preparatum, Semen Sesami Nigrum, black pepper, Semen Torreyae, Semen Coicis, Fructus Hordei Germinatus, Semen Sinapis, bright Pemisetum flaccidum Griseb., Folium Nelumbinis, Folium Mori, Herba Portulacae, fresh Rhizoma Phragmitis, or other Chinese herbal medicine, plant amedica.

The plant amedica extract can be baicalin, the baicalin of Radix Scutellariae, as antibiotic, protect the liver, antioxidation, anticancer disease; The resveratrol of Rhizoma Polygoni Cuspidati is as antioxidation, anti-hypoxia, anticancer disease, blood fat reducing; The TANSHINONES of Radix Salviae Miltiorrhizae, danshensu, former catechu as microcirculation improvement, have good effect to coronary heart disease, myocardial ischemia.

SOD is the free radical street cleaner, remove patient's unnecessary free radical (patient often free radical is more than the normal person), be absorbed by the body when advancing into drug effect at medicine, interior free yl removed, medicine is absorbed by human body comprehensively with SOD, the performance maximum efficacy, because the drug effect of radical pair medicine directly influences, drug effect was had a greatly reduced quality, the reason of medicine can not bring into play maximum effect that Here it is in the past, have to increase dose, tackle the infringement of free radical on the one hand; Performance is renderd a service to disease on the other hand, has not nowadays had the side effect of free radical, and the efficacy of a drug has just strengthened greatly.Take SOD for a long time and both can remove free radical, free radical is disappeared or minimizing, its amount of medication has significantly reduced when curing the disease, drug effect is better than compound medicines, and this is the preferred approach that the medicine performance is renderd a service, and is a kind of brand new ideas, will make major contribution for the human health cause, these of the present invention just one big characteristics will cause the revolution of materia medica, biology, pharmacology, pharmacodynamics, cause the new thinking of treatment disease.

SOD and Chinese medicine merge the Therapeutic Method that uses, and utilize both complementary functions, can change the shortcoming that both use unsatisfactory curative effect respectively.

The use of Chinese medicine is more and more general in the world in recent years, and Chinese medicine and natural goods comprise that the sales volume of antioxidant all increases like multiple every year; We propose to replace or assist western medicine with the Chinese medicine natural goods, have obtained good effect, at home, Thailand, Japan, the U.S. and Europe more and more generally paid attention to.

Confirm by experiment:

1, antioxidant activity experiment: detection method chemiluminescence, protein electrophoresis, biochemical measurement, UV scanning.Capsule 's content weight: 0.35 ± 0.05g/ grain; Antioxidant activity, every capsules anti-oxidant vigor is equivalent to 3200 SOD active units; Sample 60 ℃ the heating 2 hours after its anti-oxidant vigor be equivalent to 650 SOD unit of activity; Determining the protein quantity: sample is measured total protein meeting content 9.5mg/ grain, albumin content＜2mg/ grain on Hitachi's automatic clinical chemistry analyzer; Protein electrophoresis is analyzed: sample thief (concentration is 50mg/ml) and bovine serum albumin (25mg/ml), and electrophoresis under the standard conditions, show sample does not have protein band as a result, and the colour developing of standard quality controlled serum and bovine serum albumin is all very clear; Metal ion is measured in the sample: show that every capsules contains magnesium 0.25mg, do not measure calcium, phosphorus, ferrum plasma; UV scanning: it is all constant at the 260nm place to show whether no matter sample heat its maximum absorbance, brief summary: contain anti-oxidation active substance in this sample.

2, radioprotective experiment: matched group NS; The test group corn SOD, the experiment of peripheral blood leucocyte counting, date processing and result judge, leukocyte count is a measurement data, adopt variance analysis, but need to carry out homogeneity test of variance earlier by the program of variance analysis, variance is neat, calculates the P value, P value＜0.05, conclusion: difference has significance between test group and the matched group, the peripheral blood leucocyte counting of P＜0.05 pre-irradiation is used for respectively organizing the harmonious check of leukocyte count purpose, and dosage group and radiation model control group are relatively, difference does not have significance, proceeds irradiation and subsequent experimental.The leukocyte count that shines back 3 days radiation model control group carries out self relatively with pre-irradiation respectively, and difference has significance, and the radiation damage model is set up, the 5th day, the 14th day dosage group in irradiation back and the comparison of radiation model control group, total white blood cells increases, and difference has significance, and this tests positive.

Leukocyte count is relatively before and after the radiation:

C(0) C(5) C(14) T(0) Y(5) T(14)

Mean 7.55 0.6883 2.2000 7.28 1.38 2.84

P 0.80 0.0044 0.0479

SOD 1.58 1.31 0.18 0.48 1.37 0.53

3, resisting fatigue experiment: medicine preparation (0.5ml//time), experiment group B, 12mg/ml P+L (2/3-100ml); Test group C, 12mg/mlP+L (2/3-100ml); Corn SOD (4000U/ml); Test group D16mg/ml Trionyx sinensis Wiegmann glue; Test group E80mg/ml Trionyx sinensis Wiegmann glue, the alleviating physical fatigue function.Can stablize 24h under the carbamide room temperature in the serum, can stablize more than 7 days at 4-6 ℃.Blood lactic acid is compared with matched group, and experiment group B, C, D, E and control group A compare, and the P value is respectively 0.04,0.84,0.17,0.19.Difference has significance, and this tests positive.

Carbamide in the serum compares:

Contr0l B C D E

UN 9.2±0.9 8.5±1.3 7.7±1.0 9.4±0.9 8.5±1.2

P 0.2467 0.0083 ^☆ 0.6052 0.2135

Mice swimming with a load attached to the body time ratio is:

Control B C D E

MEAN 88 114 116 95 103

SOD 20.74825 31.48714 28.2101 26.96368 13.62351

p 0.055799 0.028482 0.516779 0.084634

According to the cross correlation of nitric oxide, superoxide radical and superoxide dismutase, SOD may be as one of effective ingredient of oral formulations.It can be used for preventing and treating gastral chronic inflammatory disease, and can prevent or the interior cancer of auxiliary treatment digestive tract.High-new engineering enzyme engineering is to utilize the catalytic action of enzyme to carry out the material transformed technology, be that the enzyme that will have specific catalysis in the organism separates, in conjunction with the chemical industry technology, in liquid medium, be fixed on the specific solid phase carrier, as urging the not reactor of biochemical reaction, and enzyme is carried out chemical modification, or adopt the structural transformation of polypeptide chain, enzymology stability, catalytic performance even antigen performance are changed, to reach the engineering of specific purpose.Enzyme engineering is widely used functional food, such as the manufacturing of effect compositions such as functional oligose, peptide, aminoacid, vitamin.SOD is a kind of important enzyme of defence oxidative damage in the organism, and energy catalysis superoxide radical generation dismutation reaction is kept the interior ultra-large type oxygen-derived free radicals of cell and is in harmless low-level state.

SOD has been applied to fields such as medicine, food, health product, cosmetics as broad-spectrum enzyme, and the application of SOD in plant amedica or its extract has the effect that strengthens cellular immune function, macrophage phagocytic function and humoral immune function.Active oxygen is the important participant of plant amedica or its extract oxidation, adds SOD and can prevent plant amedica or its extract oxidation.

We use free radical biology, free radical medical science, Chinese medicine are learned and the threpsology, in plant amedica or its extract, add and contain antioxidant SOD and antioxidant vitamins is main complexing agent, become SOD plant amedica or its extract, through a series of experiments, prove that it is a kind of medicine efficiently or health product.The permeability of SOD in the human small intestine greatly improves; Rate of release improves; Effect and effective rate of utilization improve greatly; can effectively break through of the restriction of body biological barrier to the effect of medicine food; make medicine food enter blood circulation better; the natural biological barrier that human body has many protection bodies to be without prejudice, as blood brain barrier, blood-eye barrier; cell biological envelope barrier etc.; general medicine is difficult to by these body biological barriers, and the SOD microgranule then can pass these barriers, and lesions position is played therapeutical effect.

SOD has effects such as the mottle of removing, chloasma, wrinkle to Ms's skin, and can increase the elasticity of skin membrane, prevents aging; The man there is allaying tiredness, eliminates subhealth state, improves antiviral ability, prevent old and feeble effect, and can reduce prostatitic morbidity risk rate.This technology has overcome the application limitations and the deficiency of bio proteases such as present SOD, has opened new gate for its extensive use, is suitable for penetration and promotion.

Description of drawings

Accompanying drawing 1SOD of the present invention and Chinese Medicine and Clavicular sketch map, Fig. 2 resisting fatigue experimental result is sketch map relatively.

The specific embodiment:

Embodiment 1

SOD and plant amedica or its extractive composition, proportioning are SOD 10,000 active units: plant amedica 1 gram.

Embodiment 2

We adopt a kind of corn superoxide dismutase from corn SOD compound enzyme method for large scale production, and the SOD mother solution of producing can reach 600-1000 active unit/gram; SOD dry powder can reach 4000-6000 active unit/gram.

Embodiment 3

Treatment acute hepatitis B medicine: SOD mother solution 6g, 4800 active units, Herba Sidae Rhombifoliae soup 1g, Artemisia anethoicles Mattf soup 0.5g; Every day three times, taking medicine before meal is used.The result: amine transferring enzyme SGOT and SGPT promptly descend after beginning to take rapidly; HbsAg also descends rapidly, and after virus disappeared, the also very fast generation of various antibody was fast than common speed.We find the patient at the hepatitis initial stage, and SOD rolls up, and SOD is lower than normal value before convalescent period.When acute stage, a large amount of hepatocyte breakages, intracellular SOD is released out to blood, SOD raises in the blood plasma and make; In the acute end of term, cell is impaired to be weakened, and SOD reduces to minimum in the blood plasma.When convalescent period, SOD gos up gradually to normally.

Embodiment 4

The treatment diabetes medicament: SOD dry powder 3g, 15000 active units, ZHIBAIDIHUANG 1.5g, every day three times, taking medicine before meal is used.The result: the long-term diabetes of patient, complication foot ulcer is used the blood sugar lowering Western medicine for many years.After the medication not only blood glucose obviously descend, foot's ulcer also in one month the healing; Cholesterol in the blood and triglyceride also have improvement.

Embodiment 5

Sargassum: for Sargassaceae plant sheep dwells and the frond of Sargassum.The frond yellowish-brown, meat, high 20～50cm also can reach more than the 2m.2～3 pieces of base portion tool acrospires, early fallout.Trunk is upright, and branch is cylindrical, diameter 2～4mm.Grow in low tide that unrestrained water slug is often arranged and greater than on the rock under the damp line.Chemical constituent 1, Sargassum fusiforme (Harv.) Setch contain alginic acid 15.32%～32.18%, mannitol 2.21%～7.78%, iodine 32.2%～84.2%, potassium oxide 3.23%～11.67%, total ash 19.72%～37.53%, Hijiki polysaccharide and laminaran; 2, Sargassum contains alginic acid, mannitol, and iodine, potassium, crude protein, ash, sargassan also contains the phospholipids compounds based on cephalin; Pharmacology: hypotensive effect; The anticoagulant effect; Effect for reducing blood fat; Influence to body's immunity; Antitumor action; Anti-infectious function; Other effects; Salty in the mouth, cold in nature.Return liver, stomach, nerve.Function with cure mainly: eliminating phlegm and softening indurated mass, diuretic detumescent; Main goiter, scrofula, swelling of the scrotum, beriberi is floating catches.Use and compatibility: be used for goiter, scrofula, swelling of the scrotum; The salty energy of Sargassum softening the hard mass, vanishing sputum and dispelling knot; Term beriberi edema.Usage and dosage: for oral administration: fry in shallow oil soup, 5～15 grams; Or go into ball, loose; External: the amount of living, grind into powder to apply or smash to apply and count.Attached side: control soldier's sacculation under the neck; Control goiter; Control five kinds of goiter; Control toxic goiter, stony goiter; Treating the liver is through goiter; Control under the jaw scrofula and go into to cover Lee; Control Serpentis dish scrofula such as prunus mume (sieb.) sieb.et zucc. Lee; Control hernia; Control nephritic proteinuria; Give birth to proud flesh on the training the body.

Treatment beriberi edema medicine: SOD mother solution 6g, 6000 active units, Sargassum 6g.

Embodiment 6

Semen Nelumbinis: be the fruits and seeds of nymphaeaceae plant lotus.Perennial aquatic draft.Plump horizontal walk of rhizome, the crust yellow-white, joint portion hangs, and scale leaf and indefinite is arranged, and internode expands, words spoken by an actor from offstage, hollow and the pipe of many bar shapeds is arranged.Spontaneous or cultivate in the pond; Composition: contain the starch and the Raffinose of volume, protein 16.6%, fat 2.0%, carbohydrate 62%, calcium 0.089%, phosphorus 0.285%, ferrum 0.0064%.Sub-pod contains nuciferine, N-demethyl nuciferine, oxoushinsunine and N-noramepavine.Oxoushinsunine has the nasopharyngeal carcinoma of inhibition ability; Usage and consumption are for oral administration: fry in shallow oil soup, the 10-20 gram; Or go into ball, loose.Choosing side: it is more than to control chronic dysentery; Control the inferior the dysentery anorexia, the popular name fasting dysentery; Control fasting dysentery, Semen Nelumbinis is not fried not with what, peels off shell, with the meat and the heart, grinds and is smalls; Control flaming up of heart-fire, damp and hot Sheng down, it is puckery red to urinate, stranguria with turbid discharge metrorrhagia and leukorrhagia, cards such as seminal emission; Control heart channel deficiency-heat, the urine red turbid urine; Control the urine nebulousurine, nocturnal emission is let out essence; The tonify deficiency benefit is decreased; Cure the disease the back stomach a little less than; Control regurgitation of food from the stomach; Cold syndrome of the stomach cough with dyspnea after managing property, vomiting is not eaten or abdominal distention.

Treatment cold syndrome of the stomach cough with dyspnea in puerperal, vomiting is not eaten or the abdominal distention medicine: SOD dry powder 6g, 4800 active units, oxoushinsunine 1.5g.

Embodiment 7

Tremella: be the sporophore of Tremellaceae Tremella.Former plant: the sporophore pure white, colloid, translucent, wide 5-10cm is made up of the limb that majority is wide and thin, and is soft when fresh, does after-contraction.Load is subsphaeroidal, vertical separation, (10～13) um* (9～10um).Spore is colourless, and is smooth, subsphaeroidal, (6～8.5) um* (4～7um).Chemical constituent: contain Tremella entity polysaccharide, tremella polysaccharide spore (TPS), polysaccharide TP-1, glycoprotein TP, cell wall polysaccharides, glucuronic acid xylomannan, neutral polysaccharide, acid assorted polysaccharide.From the tremella spore that plate method obtains, separate obtaining 3 polysaccharide: TF-A, TF-B and TF-C, its relative molecular mass is respectively 76000,76000 and 70000.Contained lipid components, the part of its ancient unit of weight, equal to one fourth of a liang alcohol contain 16.8% Ergota ancient unit of weight, equal to one fourth of a liang alcohol, 28.5% Ergota ancient unit of weight, equal to one fourth of a liang-7-alkene-3B-alcohol; Fatty acid part contains 1.32% hendecanoic acid, 2.37% dodecylic acid, 1.28% tridecanoic acid, 0.09% tetradecanoic acid, 5.43% pentadecanoic acid, 17.20% hexadecanoic acid, 3.11% octadecanoid acid, 2.37% 16 carbon-olefin(e) acid (9) 38.83% 18 carbon-(9)-olefin(e) acids, 27.98% 18 carbon-(9,12)-dienoic acid; Phospholipid moiety contains phosphatidyl glycerol. Phosphatidylserine, phosphatidylcholine and phosphatidylinositols.In addition, contain Sa Buddhist nun tannin A, B, C, D in the Portugal mycelia.Pharmacology: to the influence of Immune Effects (1) to non-specific immunity; (2) to the influence of humoral immunization; (3) influence of pair cell immunity; (4) to the influence of immune organ weight; Antitumor action; Anti-radiation and function of increasing leukocyte; Influence to hemopoietic system; Effect to liver; Anticoagulant and thromboembolism preventing effect; Antiinflammatory action; Effect for reducing blood fat; Hypoglycemic activity; Antiulcer action; Antimutagenic effect; Delaying senility function; Promote protein and biological nucleic acid synthetic; The film protective effect; Function cures mainly: the lung moistening nourishing the stomach is promoted the production of body fluid in nourishing.Cure mainly cough due to consumptive disease, sputum mixed with blood, Tianjin is few thirsty, body void after being ill, shortness of breath and fatigue.Usage and dosage: for oral administration: fry in shallow oil soup, 3～10 grams; Or water-ice sugar, meat clothes.Attached side: lung moistening, cough-relieving, deficiency of lung-YIN is controlled in nourishing, cough, expectorant is few, and is thirsty; Control consumption of body fluid caused by febrile disease, thirst and drinking; Be used for cancer radiotherapy, chemotherapy phase; Control the essential hypertension modern clinical research: the treatment chronic tracheitis; The treatment pulmonary heart disease; The treatment leukopenia.

Treatment chronic tracheitis medicine: SOD mother solution 6 grams, 4800 active units, tremella polysaccharide spore 1 gram.

Embodiment 8

Be purification SOD and plant amedica or its extractive composition as intermediate, be used for food, health product, medicine, cosmetics, daily-use chemical industry goods, carrying of tobacco and wine goods stopped.

Embodiment 9

Be purification SOD and plant amedica or its extractive composition, as the carrier of soft capsule, capsule, Emulsion, tablet, injection or other dosage form.

Embodiment 10

Be purification SOD and plant amedica or its extractive composition, can add various medicines according to various objectives, as the carrier of multiple formulations.

Claims (10)

1, the compositions of SOD and plant amedica or its extract, its proportioning is: SOD 1000-1 ten thousand active units: plant amedica 1-50 gram.

2,, be SOD mother solution 6 grams, 4800 active units, Herba Sidae Rhombifoliae soup 1 gram, Artemisia anethoicles Mattf soup 0.5 gram according to the compositions of the described SOD of claim 1 and plant amedica or its extract.

3,, be SOD dry powder 3 grams, 15000 active units, ZHIBAIDIHUANG 1.5 grams according to the compositions of the described SOD of claim 1 and plant amedica or its extract

4,, be SOD mother solution 6 grams, 4800 active units, berberine 6 grams according to the compositions of the described SOD of claim 1 and plant amedica or its extract.

5,, be SOD dry powder 6 grams, 4800 active units, oxoushinsunine 1.5 grams according to the compositions of the described SOD of claim 1 and plant amedica or its extract.

6, the preparation of compositions method of SOD and plant amedica or its extract is to add in the SOD plant amedica or its extract.

7,, be that the SOD mother solution can reach 600-1000 active unit/gram according to the preparation of compositions method of the described SOD of claim 6 and plant amedica or its extract; SOD dry powder can reach 4000-6000 active unit/gram.

8, preparation of compositions method according to the described SOD of claim 6 and plant amedica or its extract, be plant amedica can be food be again the medicine plant, as as Semen Ziziphi Spinosae, Fructus Gardeniae, CitrusaurantiumL.Var.amara Engl., Fructus Momordicae, Cortex Cinnamomi, Semen Raphani, Pericarpium Citri Reticulatae, Fructus Amomi, Fructus Mume, Semen Myristicae, the Radix Angelicae Dahuricae, Flos Chrysanthemi, Herba Pogostemonis, Fructus Hippophae, Semen Pruni, Fructus Canarii, Bulbus Allii Macrostemonis, Herba Menthae, Flos Caryophylli, Rhizoma Alpiniae Officinarum, Semen Ginkgo, Fructus Citri, Fructus Cannabis, orange, Poria, Herba Moslae, Folium Perillae, Fructus Anisi Stellati, Semen Canavaliae, Rhizoma Zingiberis Recens, Fructus Jujubae, Rhizoma Dioscoreae, Fructus Crataegi, Fructus Foeniculi, SENGUA, Arillus Longan, Semen Lablab Album, Bulbus Lilii, Pericarpium Zanthoxyli, Semen Euryales, Semen Phaseoli, Fructus Citri Sarcodactylis, Caulis et Folium Lactucae sativae, Semen Armeniacae Amarum, Thallus Laminariae (Thallus Eckloniae), Semen Persicae, Semen Nelumbinis, Fructus Mori, Herba Cichorii, Semen Sojae Preparatum, Semen Sesami Nigrum, black pepper, Semen Torreyae, Semen Coicis, Fructus Hordei Germinatus, Semen Sinapis, bright Pemisetum flaccidum Griseb., Folium Nelumbinis, Folium Mori, Herba Portulacae, fresh Rhizoma Phragmitis, or other Chinese herbal medicine, plant amedica.

9,, be that the plant amedica extract can be the baicalin of Radix Scutellariae, baicalin according to the preparation of compositions method of the described SOD of claim 6 and plant amedica or its extract; The resveratrol of Rhizoma Polygoni Cuspidati; The TANSHINONES of Radix Salviae Miltiorrhizae, danshensu, former catechu.

10, the application of the compositions of SOD and plant amedica or its extract is that SOD and plant amedica or its extractive composition as intermediate, are used for the carrier of food, health product, medicine, cosmetics, daily-use chemical industry goods, tobacco and wine goods; Be carrier as soft capsule, capsule, Emulsion, tablet, injection or other dosage form; Be to add various medicines, as the carrier of multiple formulations according to various objectives.

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