CN1616001A - Hemorrhoid treating medicine - Google Patents

Abstract

The pile treating medicine consists of alum 1-3 (in weight portions, the same below), verdigris 1-2, sophora fruit 13-23, basket kern 4-8, borneol 1-3, garden burnet 10-16, fig 20-30, metronidazole 0.4-0.8 and dexamethasone 0.001-0.002. The medicine is used in treating piles through combined soaking and sticking, and has fast hemostasis, antipruritic and detumescent effect, short heating period, simple use and no toxic side effect.

Description

Hemorrhoid treating medicine

Technical field

The invention belongs to a kind of pharmaceutical product, particularly a kind of hemorrhoid treating medicine that adopts raw material of Chinese medicine and chemicals raw material.

Background technology

Hemorrhoid are to expand because of the vein stagnation of the blood of anus or rectum end, form the lesser tubercle of projection.Mainly be divided into two kinds of internal hemorrhoid and external hemorrhoids, symptom is for itching, and is scorching hot, pain, stool band blood etc.It belongs to a kind of commonly encountered diseases, and saying so-called " ten male nine hemorrhoid " is exactly the preferably description to its universality.So the medicine of treatment hemorrhoid that is seen in report at present is many,

Summary of the invention

It is the medicine of the treatment hemorrhoid of one with raw material of Chinese medicine and the combination of chemicals raw material that the object of the invention provides a kind of.

The medicine of treatment hemorrhoid of the present invention is to be made by the raw material of following weight portion:

White sail 1-3, Aerugo 1-2, Fructus Sophorae 13-23, Rhizoma Osmundae 4-8, Borneolum Syntheticum 1-3, Radix Sanguisorbae 10-16, Fructus Fici 20-30, metronidazole 0.4---0.8, dexamethasone 0.001-0.002.

The preferential pharmaceutical formulation of recommending of the present invention is:

White sail 2, Aerugo 1.5, the Fructus Sophorae 18, Rhizoma Osmundae 6, Borneolum Syntheticum 2, Radix Sanguisorbae 13, Fructus Fici 25, metronidazole 0.6, dexamethasone 0.001.

The present invention adopts the Chinese and western drugs reasonable compatibility, has both absorbed the advantage of chemicals instant effect, has inherited Chinese medicine conditioning human body again from stop the strong point of disease recurrence at all.Medicine of the present invention is the bonded method treatment of external immersion and external application affected part, has quick-acting haemostatic powder, antipruritic and repercussive effect, can eradicate hemorrhoid in the short time and does not recur.And use simply, have no side effect.

The specific embodiment

1, decocting liquid soaks: white sail 2 grams, Aerugo 1.5 grams, the Fructus Sophorae 18 grams, Rhizoma Osmundae 6 grams, Borneolum Syntheticum 2 grams, Radix Sanguisorbae 13 grams, the Fructus Fici 25 grams after drying of weighing is pulverized, mixed, reheat decocted 30-40 minute after being soaked in water 20 minutes, decocting liquid and medicinal residues are placed clean demibain container together, metronidazole 0.6 gram and the dexamethasone 0.001 that add porphyrize restrain holding temperature about 30 degree, and demibain was soaked 30 minutes.

2, unguentum external application.White sail 2 grams, Aerugo 1.5 grams, the Fructus Sophorae 18 grams, Rhizoma Osmundae 6 grams, Borneolum Syntheticum 2 grams, Radix Sanguisorbae 13 grams, the Fructus Fici 25 grams after drying of weighing is pulverized, mixed, cross 60 mesh sieves, metronidazole 0.6 gram and dexamethasone 0.001 gram with porphyrize adds in the Chinese medicine powder then, add vegetable oil again and make unguentum, get 5 and restrain outer being attached on the anus, keep more than 40 minutes.

3, treatment is carried out once or twice every day.

Medicine of the present invention proves that through the clinical for many years use of inventor curative effect is infallible.It below is Drug therapy hemorrhoid patients clinical report of the present invention.

First: basic standard

One, case is selected

(1) Western medicine diagnose standard

Diagnostic classification standard and Ministry of Public Health new Chinese medicine clinical research in 1993 guideline according to national first anorectal in 1975 academic conference are formulated following diagnostic criteria.

1, external hemorrhoid

(1) thrombosed external hemorrhoid: because of haemorrhoidal vein breaks, clot condenses in subcutaneous, forms thrombosis, and swollen thing occurs,

(2), inflammatory external hemorrhoid: local red and swollen, the pain of blood stasis, and edema and hyperemia are arranged.

2, internal hemorrhoid

(1) I phase internal hemorrhoid: the very for a short time purple that is of blood stasis, matter is soft, and often hemorrhage because of the stool friction, blood stasis does not have.

(2) II phase internal hemorrhoid: blood stasis is bigger, is purple dim color, and mucosa thickens coarse, and blood stasis is deviate from outside the anus in the time of just, and after an action of the bowels from horizontal reset, amount of bleeding is less.

(3) III phase internal hemorrhoid: blood stasis is grey dim color, and matter is harder, and mucosa thickens coarse, and it is little to have blood in stool, and not only blood stasis is deviate from during defecation, even also deviates from when squatting down, coughing or walking.

3, mixed hemorrhoid

Being positioned at the tooth trace upper and lower all has blood stasis, the inside and outside hemorrhoid two aspect symptoms of tool.

4, diagnose in conjunction with following symptom and inspection by above diagnostic criteria

(1) symptom

1. after an action of the bowels archorrhagia, bleed or penetrate blood.

2. just the time or firmly the time, blood stasis is deviate from outside the anus, but can reset from horizontal reset or hand push.

3. anus discomfort after an action of the bowels, the companion weighs down pain.

(2) inspection: the anus skin weighs down congested, and blood stasis becomes big when increasing abdominal pressure, and part patient's blood stasis is deviate from outside the anus.

(3) anoscopy: the bossed blood stasis in tooth trace place, the hemorrhoid mucosa has inflammation, and secreting mucus or companion are rotten to the corn.

(4) digital rectal examination: get rid of other pathological changes such as rectal cancer or rectal polyp.Above-mentioned 3 of meeting in (1) or (2), (3) bar, promptly diagnosable.

(2) Chinese medical discrimination

Wind is hindered the intestinal network: stool band blood, bleed or spurting hemorrhage, color is scarlet, or pruritus ani is arranged.Red tongue, white and thin fur or BOHUANG, floating and rapid pulse.

Damp invasion of lower energizer: the color aquatic foods of having blood in stool, to measure morely, swollen beyond the region of objective existence takes off in the anus, can bounce back burning sensation of the anus or swell and ache voluntarily.Red tongue, yellow and thin fur or yellow greasy, stringy and rolling pulse or sliding number.

Two, test case standard

(1) includes standard in

All Western medicine diagnoses that meets, and meet Chinese medical discrimination and belong to wind and hinder intestinal network and damp invasion of lower energizer person, all can include the test case in.

All Western medicine diagnoses that meets, and meet Chinese medical discrimination and belong to wind and hinder intestinal network and damp invasion of lower energizer person, all can include the test case in.

(2) exclusion standard

1, suffers from severe cardiac, liver, kidney disease patient.

2, be reluctant to accept to observe the case that maybe can not finish statistics by the design requirement.

3, suffer from multiple disease, hold concurrently folder disease, complication are difficult for judged result person.

4, the women of gravid woman and preparation gestation.

Three, grouping and control drug

Case be will include in,, test group and matched group will be divided at random, test group 218 examples, matched group 100 examples by the table of random number method.

Inactive all medicines relevant during the treatment (for oral administration and external) with this disease.

(1) trial drug: water decoction 1000ml demibain of the present invention is soaked, once a day; Every 5g of ointment, (5g) once a day injects anal or is coated with the affected part.All medicine logotypes 7 days.

(2) control drug: the domestic same veriety that gone on the market

Packing 10g/ props up.Usage, consumption, the course of treatment same test group.

Four, observation index

(1) safety indexes

1. general health check-up project.

2. blood, urine, just routine examination.

3. the heart, liver, kidney function test.

(2) health giving quality index

1, related symptoms, sign.

2, anoscopy.

Five, curative effect determinate standard

Curative effect of disease (drafting) according to national anorectal academic conference formulation standard in 1975

(1) recovery from illness: do not have hemorrhagely after an action of the bowels, do not have prolapsus, it is normal that anoscopy hemorrhoid mucosa recovers, the blood stasis atrophy.

(2) produce effects: do not have hemorrhagely after an action of the bowels, nothing is deviate from, and the blood stasis redness obviously disappears, and pain disappears.Anoscopy, internal hemorrhoid mucosa mild hyperaemia, blood stasis diminishes.

(3) take a turn for the better: have after an action of the bowels hemorrhage on a small quantity, pain relief, the companion is prolapsus slightly, anoscopy hemorrhoid mucosa mild hyperaemia.

(4) invalid: after the medication clinical symptoms anoscopy with control Wen Qianwu and be clearly better or increase the weight of.

Clinical symptoms, sign comprehensive therapeutic effect standard

Consider that the external traditional Chinese herb medicine still can not use internal hemorrhoid and external hemorrhoid atrophy of connective tissue type or disappearance, only can make part hemorrhoid edema or thrombosed hemorrhoids dwindle.So in clinical trial our emphasis according to hemorrhoid cause hemorrhage, deviate from, pain and hemorrhoid mucosa state, several symptoms of external hemorrhoid edema are carried out primary part observation, do not observe the blood stasis atresia.When respecting above-mentioned standard, each cardinal symptom is quantized according to light and heavy degree, the evaluation score value, the score value before and after the last foundation treatment is added up, and judges curative effect.Every routine total points is up to 40 fens, and the expression symptom and sign all disappears, and symptom is heavy more, and score value is low more.When clinical card shape, sign comprehensive therapeutic effect are judged, with score value as foundation.

Be almost recovered: 40 minutes.Be meant all kinds of transference cures of hemorrhoid, but blood stasis exists still, can be called the symptom recovery from illness.

Produce effects: 38-36 branch (or score value increases more than 10 minutes and 10 minutes before the treatment).

Effectively: 36-32 branch (or score value increases more than 6 minutes and 6 minutes before the treatment).

Invalid: treatment is preceding, treatment back score value does not have significant change, or score value increases below 3 minutes.

Concrete standards of grading are seen attached list.

Subordinate list: clinical card shape, sign comprehensive observing standards of grading and curative effect standards of grading

1, has blood in stool	Nothing is had blood in stool	8 minutes		Weigh down pain	6 minutes
							Band blood	6 minutes		Severe pain	3 minutes
	Bleed	4 minutes	4, mucosa	Normally	8 minutes
							Penetrate blood	2 minutes		Congested	6 minutes
2, prolapsus	There is not prolapsus	8 minutes		Rotten to the corn	4 minutes
							Can be from horizontal reset	6 minutes		The petechia	2 minutes

	Reset after the rest	4 minutes	5, external hemorrhoid	No edema redness	8 minutes
							Hand push resets	2 minutes	Edema	The external hemorrhoid edema	6 minutes
	Can not reset	0 minute		The external hemorrhoid redness	4 minutes
						3, pain	There are not the pain of bob and pain	8 minutes		The external hemorrhoid erosion	2 minutes

Second portion: physical data

One, experimental condition and sex composition (example)

Group	Add up to	Experimental condition		Sex
						Be in hospital	Outpatient service	The man	The woman
		Test group	????218	??38	??180					??134	??84
Matched group	????100					??54	??46	??68	??32

Two, the age:

Table 2 age distribution situation (example)

Group	Add up to	????20-	????30-	??40-	??50-
						Test group	????218	????21	????99	??55	??43
Matched group	????100	????16	????35	??46	??3

Three, the course of disease distributes:

Table 3 course of disease distribution (example)

Group	Add up to	≤ 1 year	-10 years	-20 years	-30 years	More than 30 years
							Test group	218	98	68	31	13	8
Matched group	100	65	16	9	6	4

Four, disease: the relative analysis of primary symptom

Respectively organize the clinical symptoms statistical table before table 4 treatment

Classification	Primary symptom	Test group		Matched group		The P value
							Example %		Example %
		Have blood in stool	Band blood	68	?31.2						?29	?29	＞0.05
Bleed	87					?39.9	?31	?31
			Penetrate blood	57	?25.1				?26	?26
Hemorrhoid are taken off	Can recover voluntarily					41	?18.9	?11			?11	＞0.05
		Hand push recovers	76	?35.0	?38				?38
	Can not recover					32	?14.6	?11		?11
		Proctalgia	Weigh down pain	124	?57.0				?62		?62		＞0.05
Severe pain	89					?40.9	?40	?40
			The hemorrhoid mucosa	Congested	117				?53.7	?58	?58	＞0.05
Rotten to the corn	56	?25.6				?29	?29
				The petechia	34			?15.6	?17	?17
Local inspection	The external hemorrhoid edema	26				?11.9	?13				?13		＞0.05
			The external hemorrhoid redness	48	?22.0			?26	?26
	The external hemorrhoid erosion	16				?7.34	?8			?8

Third part: result

For continuous use 7 days patient of Drug therapy of the present invention and matched group patient, the symptom combined treatment standard after 7 days is added up as following table:

The result	Test group		Matched group
					The example number	?％	The example number	?％
	Be almost recovered	169	?77.5	?54					?54
Produce effects					27	?12.4	?13	?13
	Effectively	24	?11.1	?2					?2
Invalid					8	?3.7	?31	?31

The test group aggregate efficiency is 96.3%, and the matched group total effective rate only is 69%.Prove that medicine of the present invention has good therapeutic effect for various hemorrhoid, and effect is significantly better than existing medicine.

In full trimestral visit was examined subsequently, test group had 167 people's feedback informations, and wherein 158 people do not have recurrence, and 9 people all be the heavy worker, caused having slight rebound phenomenon owing to overworked, did not influence the judgement to this curative effect of medication.

Claims (2)

1, a kind of medicine for the treatment of hemorrhoid is characterized in that being made by the raw material of following weight portion:

White sail 1-3, Aerugo 1-2, Fructus Sophorae 13-23, Rhizoma Osmundae 4-8, Borneolum Syntheticum 1-3, Radix Sanguisorbae 10-16, Fructus Fici 20-30, metronidazole 0.4---0.8, dexamethasone 0.001---0.002.

2, a kind of medicine for the treatment of hemorrhoid according to claim 1 is characterized in that being made by the raw material of following weight portion:

White sail 2, Aerugo 1.5, the Fructus Sophorae 18, Rhizoma Osmundae 6, Borneolum Syntheticum 2, Radix Sanguisorbae 13, Fructus Fici 25, metronidazole 0.6, dexamethasone 0.001.