CN1915375A - Chinese traditional medicine for expeling wind and cold, relaxing muscles and tendons, harmonizing link and alleviating pain, and method for fabricating dog skin plaster purpose made - Google Patents

Abstract

A Chinese medicine in the form of plaster on dog's hide for treating rheumatic arthritis and rheumatic arthrodynia, and promoting blood circulation is prepared from methyl salicylate, bagodryl hydrochloride, belladonna extract, nitrone, and 44 Chinese-medicinal materials including gastrodia tuber, liquorice root, Chuan-xiong rhizome, peach kernel, etc. Its preparing process is also disclosed.

Description

Expelling wind and cold, relaxing muscles and tendons to promote blood circulation and network analgesic Chinese medicine and special dog skin plaster method for making

Technical field

The present invention relates to a kind of Chinese medicine, relate in particular to a kind of the have Chinese medicine of expelling wind and cold, relaxing muscles and tendons to promote blood circulation and network pain-relieving functions and the preparation method of special dog skin plaster thereof.

Background technology

Anemofrigid-damp arthralgia, shoulder arm lumbago and skelalgia, numb limbs and tense tendons, traumatic injury, arthralgia etc. are common disease, are more common in person in middle and old age, physical labourer, children etc., though harm is little, to the misery that people cause, are tangible.The therapeutic modality of daily life, work is sought simply, is easy to get, do not influence to most of patients.In the middle of China's traditional treatment,, reach and solve the purpose of suffering from pain, and develop thus and traditional black plaster of coming how with the topical therapeutics of the outer application mode of medicine, promptly be with medicine by behind the vegetable oil extraction, add lead oxide, Plumbum preparatium is refined into cream, stick in the affected part.Since black plaster have at normal temperatures harden, pollution clothes and easily cause shortcomings such as environmental pollution, quality be uncontrollable, the patient in use, compliance is relatively poor.The rubber paste formulation promptly is to develop on this basis and next local external use's treatment preparation.Be characterized in the ingredient after extracting according to certain technology, adding certain simultaneously is that the ingredient medicine that plays the Transdermal absorption facilitation again is in the same place with Percutaneous absorption enhancer and the refining of base rubber cream, coat on the carrier of cotton or various quality, stick in the skin affected part and treat, thereby changed the shortcoming of black plaster, made things convenient for patient's medication.Therefore, the sick rubber paste formulation kind of treatment rheumatism etc. is of all shapes and colors.

Diseases such as anemofrigid-damp arthralgia, shoulder arm lumbago and skelalgia, numb limbs and tense tendons, traumatic injury, arthralgia, have course of disease length, touching characteristics repeatedly, doctor trained in Western medicine is except the oral analgesic quickly alleviating pain, for treatment of diseases, also there is not effective method, and these analgesic are many to have the hepatic and renal function damage, should not take for a long time.The traditional external application activating blood circulation to dissipate blood stasis of China, the Therapeutic Method of reducing swelling and alleviating pain medicine but often can prove effective.Treating the medicine of this class disease, is the compound recipe combination of multiple activating blood circulation to dissipate blood stasis, anti-inflammatory analgetic class Chinese medicine mostly, and number and role according to every class medicine emphasize particularly on different fields.Drug regimen of the present invention, its particularity are in this combination that flavour of a drug quantity is many, and contain other and make up unexistent multiple expensive thin medicine such as Sanguis Draxonis, Squama Manis, Rhizoma Gastrodiae etc., and be on curative effect, with the obvious advantage.Simultaneously, not containing Moschus in the medicine of the present invention, do not influence fertility, thereby do not limit women, children, is to be suitable for crowd's medicine widely.

Summary of the invention

The present invention provides a kind of Chinese medicine with expelling wind and cold, relaxing muscles and tendons to promote blood circulation and network pain-relieving functions in order to solve the described technical problem of background technology part, purpose provides a kind of women, children of not limiting, suitable crowd is medicine widely, it is evident in efficacy that it belongs to syndrome of cold-dampness blocking collaterals type person to treatment rheumatic arthritis and cold rheumatoid joint pain, but life-time service and safe and reliable.

Another object of the present invention provides a kind of preparation method with special dog skin plaster of expelling wind and cold, relaxing muscles and tendons to promote blood circulation and network pain-relieving functions Chinese medicine.

Following 48 crude drug of medicament selection of the present invention make up, make each efficacy of drugs produce synergism these drug regimens, have expelling wind and cold, relaxing muscles and tendons to promote blood circulation and network analgesic function, thereby can effectively treat anemofrigid-damp arthralgia, shoulder arm lumbago and skelalgia, numb limbs and tense tendons, diseases such as traumatic injury.The consumption of drug component of the present invention be through the inventor carry out a large amount of grope to sum up with experimentation draw, the weight ratio of each raw material has curative effect preferably in following weight range, then effect is relatively poor to exceed the following weight scope.

To achieve these goals, the present invention is achieved in that a kind of expelling wind and cold that has, relaxing muscles and tendons to promote blood circulation, with the Chinese medicine of network pain-relieving functions, its active component is made up of the fractional component of following weight: Fructus Aurantii 300-700, Herba Asari 300-700, Halloysitum Rubrum 300-700, Caulis Sinomenii 300-700, Rhizoma Gastrodiae 300-700, Pericarpium Citri Reticulatae Viride 300-700, Rhizoma Et Radix Notopterygii 300-700, Radix Linderae 300-700, Radix Aconiti 300-700, Radix Glycyrrhizae 300-700, Radix Ampelopsis 300-700, Cortex Phellodendri 300-700, Rhizoma Chuanxiong 0-1000, Radix Aucklandiae 300-700, Radix Polygalae 300-700, Semen Persicae 300-700, Rhizoma Atractylodis Macrocephalae 300-700, Radix Aconiti Kusnezoffii 300-700, Fructus Foeniculi 300-700, Squama Manis 300-700, Semen Cuscutae 300-700, Fructus Toosendan 300-700, Fructus Cnidii 300-700, Radix Clematidis 300-700, Semen Hydnocarpi 300-700, Radix Paeoniae Rubra 300-700, Radix Achyranthis Bidentatae 300-700, Fructus Psoraleae 300-700, Radix Dipsaci 300-700, Radix Aconiti Lateralis Preparata 300-700, Cortex Eucommiae 300-700, Rhizoma Cyperi 300-700, Bombyx Batryticatus 300-700, Radix Angelicae Sinensis 300-700, Pericarpium Citri Reticulatae 300-700, Cortex Cinnamomi 0-1000, catechu 100-400, Olibanum 100-400, Sanguis Draxonis 100-400, Myrrha 100-400, Flos Caryophylli 100-400, Camphora 300-700, methyl salicylate 0-1200; very thin oily 0-2000; Borneolum Syntheticum 0-2000; diphhydramine hydrochloride 80-220; Semen daturae fluid extract 8-35; Percutaneous absorption enhancer 0-200.

Described Chinese medicine, its active component is made up of the fractional component of following weight: Fructus Aurantii 400-600, Herba Asari 400-600, Halloysitum Rubrum 400-600, Caulis Sinomenii 400-600, Rhizoma Gastrodiae 400-600, Pericarpium Citri Reticulatae Viride 400-600, Rhizoma Et Radix Notopterygii 400-600, Radix Linderae 400-600, Radix Aconiti 400-600, Radix Glycyrrhizae 400-600, Radix Ampelopsis 400-600, Cortex Phellodendri 400-600, Rhizoma Chuanxiong 400-600, Radix Aucklandiae 400-600, Radix Polygalae 400-600, Semen Persicae 400-600, Rhizoma Atractylodis Macrocephalae 400-600, Radix Aconiti Kusnezoffii 400-600, Fructus Foeniculi 400-600, Squama Manis 400-600, Semen Cuscutae 400-600, Fructus Toosendan 400-600, Fructus Cnidii 400-600, Radix Clematidis 400-600, Semen Hydnocarpi 400-600, Radix Paeoniae Rubra 400-600, Radix Achyranthis Bidentatae 400-600, Fructus Psoraleae 400-600, Radix Dipsaci 400-600, Radix Aconiti Lateralis Preparata 400-600, Cortex Eucommiae 400-600, Rhizoma Cyperi 400-600, Bombyx Batryticatus 400-600, Radix Angelicae Sinensis 400-600, Pericarpium Citri Reticulatae 400-600, Cortex Cinnamomi 400-600, catechu 200-300, Olibanum 200-300, Sanguis Draxonis 200-300, Myrrha 200-300, Flos Caryophylli 200-300, Camphora 400-600, methyl salicylate 550-850; very thin oily 900-1200; Borneolum Syntheticum 900-1200; diphhydramine hydrochloride 120-180; Semen daturae fluid extract 15-25; Percutaneous absorption enhancer 30-100.

Described Percutaneous absorption enhancer is any one in dimethyl sulfoxide, alcohol, polyhydric alcohol, ethyl acetate, oleic acid, linoleic acid, lauric acid and ester thereof, azone, anion surfactant, cationic surfactant, non-ionic surface active agent, lecithin, carbamide, the salicylic acid pyrrolidone.

Described Chinese medicine, its active component is made up of the fractional component of following weight: Fructus Aurantii 500, Herba Asari 500, Halloysitum Rubrum 500, Caulis Sinomenii 500, Rhizoma Gastrodiae 500, Pericarpium Citri Reticulatae Viride 500, Rhizoma Et Radix Notopterygii 500, the Radix Linderae 500, Radix Aconiti 500, Radix Glycyrrhizae 500, Radix Ampelopsis 500, Cortex Phellodendri 500, Rhizoma Chuanxiong 500, the Radix Aucklandiae 500, Radix Polygalae 500, Semen Persicae 500, the Rhizoma Atractylodis Macrocephalae 500, Radix Aconiti Kusnezoffii 500, Fructus Foeniculi 500, Squama Manis 500, Semen Cuscutae 500, Fructus Toosendan 500, Fructus Cnidii 500, Radix Clematidis 500, Semen Hydnocarpi 500, Radix Paeoniae Rubra 500, Radix Achyranthis Bidentatae 500, Fructus Psoraleae 500, Radix Dipsaci 500, Radix Aconiti Lateralis Preparata 500, the Cortex Eucommiae 500, Rhizoma Cyperi 500, Bombyx Batryticatus 500, Radix Angelicae Sinensis 500, Pericarpium Citri Reticulatae 500, Cortex Cinnamomi 500, catechu 250, Olibanum 250, Sanguis Draxonis 250, Myrrha 250, Flos Caryophylli 250, Camphora 500, methyl salicylate 700; very thin oily 1000; Borneolum Syntheticum 1000; diphhydramine hydrochloride 150; Semen daturae fluid extract 20; azone 60.

The present invention can adopt the conventional method of Chinese medicine preparation to make any exterior-applied formulation, as dosage forms such as crust cloth cream, black plaster, gel, ointment, aerosol, liniment, membrane.But in order to make each raw material of medicine of the present invention better bring into play drug effect, reduce cost, also be fit to patient's medication, the preparation method preferred for preparation of medicine of the present invention becomes rubber paste formulation---special dog skin plaster.But these can not be used for limiting protection scope of the present invention.

A kind of described expelling wind and cold that has, relaxing muscles and tendons to promote blood circulation, preparation method with the special dog skin plaster of network pain-relieving functions Chinese medicine, get Fructus Aurantii by described weight ratio, Herba Asari, Halloysitum Rubrum, Caulis Sinomenii, Rhizoma Gastrodiae, Pericarpium Citri Reticulatae Viride, Rhizoma Et Radix Notopterygii, the Radix Linderae, Radix Aconiti, Radix Glycyrrhizae, hold back in vain, Cortex Phellodendri, Rhizoma Chuanxiong, the Radix Aucklandiae, Radix Polygalae, Semen Persicae, the Rhizoma Atractylodis Macrocephalae, Radix Aconiti Kusnezoffii, Fructus Foeniculi, Squama Manis, Semen Cuscutae, Fructus Toosendan, Fructus Cnidii, Radix Clematidis, Semen Hydnocarpi, Radix Paeoniae Rubra, Radix Achyranthis Bidentatae, Fructus Psoraleae, Radix Dipsaci, Radix Aconiti Lateralis Preparata, the Cortex Eucommiae, Rhizoma Cyperi, Bombyx Batryticatus, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Cortex Cinnamomi, catechu, Olibanum, Sanguis Draxonis, Myrrha, Flos Caryophylli is ground into coarse powder, with alcohol reflux three times, 2-4 hour for the first time, second, three times 1-3 hour, merge three times extracting solution, being evaporated to relative density is that 1.30-1.35 is at the 65-70 ℃ of extractum of measuring down, standby, getting rubber cleans, dry down at 50-60 ℃, be cut into bulk, in rubber mixing machine, plasticate and reticulate thin slice, camphorate, Oleum menthae, the ice place, diphhydramine hydrochloride, methyl salicylate, the Percutaneous absorption enhancer mixed liquor, flooded 18-30 hour, add above-mentioned extractum, Semen daturae fluid extract, roll evenly, be applied on the cloth, itemize, punching, the lid lining, section, packing, promptly.

Advantage of the present invention and effect are as follows:

Medicine of the present invention has expelling wind and cold, relaxing muscles and tendons to promote blood circulation and network analgesic function, and rheumatic arthritis is belonged to syndrome of cold-dampness blocking collaterals type person, and above percentage rate of its produce effects and total effective rate are respectively 32% and 90%; Cold rheumatoid joint pain belongs to syndrome of cold-dampness blocking collaterals type person significant curative effect, and above percentage rate of its produce effects and total effective rate are up to 63.3% and 96.6%; Heavy to muscle arthralgia, limbs, the local symptom such as cold of sending out has significant curative effect; Arthroncus there is certain curative effect; Indexs such as antagonism chain " O " and erythrocyte sedimentation rate have certain regulating action.Simultaneously, not containing Moschus in the medicine of the present invention, do not influence fertility, thereby do not limit women, children, is to be suitable for crowd's medicine widely.

Clinical drug observed result of the present invention shows: the curative effect that this medicine treatment rheumatic arthritis and cold rheumatoid joint pain belong to syndrome of cold-dampness blocking collaterals type person is significant, and obviously is better than contrasting medicine.This medicine of clinical use is safe and reliable.

Further specify the effect of medicine of the present invention below in conjunction with clinical trial.

Medicine special dog skin plaster clinical observation of the present invention is summed up:

Summary:

Medicine special dog skin plaster of the present invention is the external plaster by Dongling Pharmaceutical Co., Ltd., Shenyang's development.This medical instrument has the function of expelling wind and cold, relaxing muscles and tendons to promote blood circulation and network pain relieving.Be used for the treatment of anemofrigid-damp arthralgia, shoulder arm lumbago and skelalgia, numb limbs and tense tendons, diseases such as traumatic injury.

Be further its clinical efficacy of checking and safety, 80 routine clinical observations have been carried out in this test, rheumatic arthritis is belonged to syndrome of cold-dampness blocking collaterals type person, and above percentage rate of its produce effects and total effective rate are respectively 32% and 90%, and curative effect obviously is better than contrasting medicine " SHEXIANG ZHUANGGU GAO ".Cold rheumatoid joint pain is belonged to syndrome of cold-dampness blocking collaterals type person, tangible curative effect is also arranged, above percentage rate of its produce effects and total effective rate are up to 63.3% and 96.6%.Paste with this medicine except that skin itching, rubescent and have the little pimple appears in individual patient, do not have other toxic and side effects and untoward reaction.

Clinical observation result shows: the curative effect that this medicine treatment rheumatic arthritis and cold rheumatoid joint pain belong to syndrome of cold-dampness blocking collaterals type person is significant, and obviously is better than contrasting the clinical use of medicine, illustrates that it is safe and reliable using this medicine.

Liaoning academy of traditional Chinese medicine of observation unit, Shenyang Inst. of Traditional Chinese Medicine.

Special dog skin plaster system is by the external plaster of Dongling Pharmaceutical Co., Ltd., Shenyang's development.For further its clinical efficacy of checking and safety, carried out clinical observation by hospitals such as Liaoning Prov. Traditional Chinese Medicine Inst and Shenyang Inst. of Traditional Chinese Medicine, now observed result is reported as follows:

One, case choice criteria

(1), clinical data

The case source is the different sexes patient who selects to meet rheumatic arthritis and cold rheumatoid joint pain diagnosis at random.Be the rheumatic arthritis patient if observe 1 group of 50 example (dog skin plaster), male's 21 examples wherein, women's 29 examples, minimum 22 years old of age, the oldest 65 years old, 45.12 ± 11.27 years old mean age.The course of disease is the shortest 0.02, and is the longest 20 years, average course of disease 3.49 ± 4.69 years.The symptom integral meansigma methods is 25.00 ± 5.03 minutes before the treatment.Contrast also is the rheumatic arthritis patient for 30 examples (SHEXIANG ZHUANGGU GAO).Male's 15 examples wherein, women's 15 examples, minimum 20 years old of age, the oldest 65 years old, 44.13 ± 12.59 years old mean age.The course of disease is the shortest 0.25, and is the longest 20 years, and average course of disease is 2.92 ± 4.16 years.The symptom average integral is 22.87 ± 5.26 minutes before the treatment.Observe 1 group and learn processing with the matched group case by statistics at sex, age, the course of disease, characteristic of disease aspects such as (symptom average product score values before the treatment), difference that there are no significant, P＞0.05, two a group case have harmony and comparability (seeing table 1 for details).Other establishes and observes 2 group of 30 example (dog skin plaster) and be the cold rheumatoid joint pain patient, male's 10 examples wherein, women's 20 examples, 45.53 ± 12.02 years old mean age, average course of disease 3.40 ± 4.65 years.

1 group of table 1 observation is relatively harmonious with matched group

Group	The example number				Symptom before the treatment
							Total example	The man	The woman	Mean age (year)	Average course of disease (year)	Integral mean (state of an illness)
	Observe 1 group of matched group	50 30	21 15	29 15	45.12±11.27 44.13±12.59	3.49±4.69 2.92±4.16							25.00±5.03 22.87±5.26

(2), diagnostic criteria

1, rheumatic arthritis diagnostic criteria

Formulate this standard according to " Clinical Researches of New Drugs guideline " related standards.

(1) clinical manifestation: acute stage, have multiple and the migration joint aches, mostly occurs in big joint, can be with redness pain or tuberosity or erythema; Chronicly can only feel joint aches.

(2) laboratory examination: anti-chain " O " is more than 1: 500, or erythrocyte sedimentation rate speeds; Or more than antistreptokinase 80 units; Or antihyaluronidase is more than 128 units; Or the c reactive protein positive.

(3) the rheumatic arthritis medical history was arranged in the past.

2, cold rheumatoid joint pain diagnostic criteria

This standard of standard formulation of combination of Chinese and Western medicine diagnostic criteria that " rheumatic four diseases " formulated according to 1985 " rheumatism tremble with fear sick academic forum " is unified and in April, 1988 whole nation combination of Chinese and Western medicine rheumatism disease disease academic conference revision.

(1) medical history: rheumatism it is attacked by the cold and evil history is arranged.

(2) symptom: some joint or muscle are miserable, numb, pain even severe pain, movable difficulty; Meet cold or Changes in weather (cloudy day, rain, the blow) state of an illness increases the weight of.

(3) sign: the joint of getting involved is limited because of movable function due to the pain, but alleviates after the activity, and most cases are the pain pneumonedema only, the minority case in the joint around mild swelling (no red heat).

(4) lab testing: erythrocyte sedimentation rate is most normal, and minority is fast slightly; Anti-chain " O ", rheumatoid factor and routine blood test all belong to normally.

(5) X ray examination: except that the visible soft tissue swelling of minority case, generally do not have sclerotin change.Some cases can be sent out hyperosteogeny.

(6) prognosis, catabasis or healing posterior joint do not stay deformity, and joint function recovery is normal.

3, traditional Chinese medical science typing standard

Syndrome of cold-dampness blocking collaterals: the limbs joint cold type of pain is heavy, or swelling, and local fear of cold, color of the leather are not red, and that touches is not hot, and pain increase in intensity under coldness must hotly then subtract, enlarged tongue, and matter is light dark, the greasy in vain or whiten of tongue, stringy and tense pulse or string are slow.

(3) test case standard

1, includes the case standard in

All diagnostic criteria and traditional Chinese medical science typing standards of meeting, the age all can be used as the observation case the patient of 18-65 different sexes between year.

2, get rid of the case standard

(1), the age is under-18s or over-65s person.

(2) merge the heart, cerebrovascular, liver, kidney and serious primary disease of hemopoietic system and psychotic.

(3) not medication in accordance with regulations can't be judged that curative effect or data are not congruent to affect the treatment or safety judgement person.

(4) gestation, preparation gestation or women breast-feeding their children.

(5) to this medicine allergy sufferers.

Two, clinic observation index

(1) safety observation index

1, general health check-up project.

2, blood, routine urinalysis, liver function, kidney merit (creatinine).

3, to local skin irritation and allergic phenomena.

(2) health giving quality observation index

1, observes muscle arthralgia, heavy, swelling, part situation of change before and after symptom such as cool sense or fear of cold, pain increase in intensity under coldness and tongue, the arteries and veins treatment is arranged.

2, the variation before and after erythrocyte sedimentation rate, the treatment of anti-chain indexs such as " O ".

Three, observation and administrated method

Observe 1 group of 50 example (rheumatic arthritis) and observe 2 group of 30 example (cold rheumatoid joint pain) and pastes all that (two weeks were a course of treatment, observed a course of treatment for specification 7 * 10cm), subsides every day one with dog skin plaster.Viewing duration is stopped using, and other has the medicine of therapeutical effect.Matched group 30 examples (rheumatic arthritis) are all pasted with SHEXIANG ZHUANGGU GAO (Liaohe River pharmaceutical factory produces, lot number 970303), and paste every day one, and the course of treatment and other require same observation group.

Four, curative effect determinate standard

(1) clinical cure: clinical symptoms all disappears, and tongue, arteries and veins recover normal, and treatment back integration is zero, and physics and chemistry detects index and recovers normal

(2) produce effects: clinical symptoms obviously alleviates, and the treatment back preceding integrated value of treatment descends 〉=2/3, and physics and chemistry detects index obviously to be improved.

(3) effective: clinical symptom relief, integrated value descended＜2/3, 〉=1/3 before treated the treatment back; Physics and chemistry detects index improvement.

(4) invalid: clinical symptoms is improved not obvious or is increased the weight of, and integrated value descended＜1/3 before treated the treatment back; Physics and chemistry detects index does not have improvement.

Five, observed result

(1) observation group and matched group clinical efficacy are relatively

1,1 group of observation and matched group clinical efficacy are relatively

1 group of table 2 observation and matched group clinical efficacy are relatively

Group	The example number	Clinical treatment		Produce effects		Effectively		Invalid		Produce effects	Effectively total
												Example	(％)	Example	(％)	Example	(％)	Example	(％)	Example (%)	Rate (%)
		Observe 1 group of matched group	50 30	6 0	12.0 0	10 5	20.0 16.7	29 13	58.0 43.3	5 12	10.0 40.0											32.0 16.7	90.0※※ 60.0

Annotate: ※ ※ P＜0.01

As seen from Table 2, observing 1 group of above percentage rate of produce effects and total effective rate is 32%, 90%, and above percentage rate of matched group produce effects and total effective rate are respectively 16.7% and 60%.Analyze through Ridit, U=2.66, there is highly significant difference P＜0.01, and the curative effect that the prompting observation is 1 group is better than matched group respectively.

2, observe 2 groups of clinical efficacies

Table 3 is observed 2 groups of clinical efficacies

Group	The example number	Clinical treatment		Produce effects		Effectively		Invalid		Produce effects above (%)	Total effective rate (%)
												Example	(％)	Example	(％)	Example	(％)	Example	(％)
		Observe 2 groups	30	6	20.0	13	43.3	10	33.3											1	3.4	63.3	96.6

As seen from Table 3, observe 2 groups above percentage rate of produce effects and total effective rate, point out this medicine that cold rheumatoid joint pain is also had better curative effect also respectively up to 63.3% and 96.6%.

(2) each clinical symptoms curative effect of observation group and matched group relatively

1,1 group of observation and matched group clinical symptoms are relatively

1 group of table 4 observation and each clinical symptoms of matched group are relatively

Symptom (Signs)	Observe 1 group						Matched group
													Total example	Control preceding integration	Control the back integration	Drop-out value	Rate of descent	Difference average before and after the treatment	Total example	Control preceding integration	Control the back integration	Drop-out value	Rate of descent	Difference average before and after the treatment
	The heavy part of muscle arthralgia limbs sends out swelling cool	50 50 48 29	254 234 121 52	70 90 39 13	184 144 82 39	72.4 61.5 67.8 75.0	3.68±1.24 ※※※ 2.92±1.58 ※※ 1.71±0.92 ※※ 1.34±0.97 ※	30 30 29 15	134 110 71 24	56 56 38 13	78 54 33 11	58.2 49.1 46.5 45.8													2.60±1.30 1.80±1.32 1.10±0.77 0.73±0.59

Annotate: treatment front and back difference meansigma methods compares ※ P＜0.05 ※ ※ P＜0.01 ※ ※ ※ P＜0.001 between group

As seen from Table 4, observe 1 group of main clinic symptoms treatment back, muscle arthralgia, a local cold and swelling are all had significant curative effect, the heavy symptom of limbs is also had certain curative effect from the integrated value rate of descent.By with treatment of control group before and after the difference meansigma methods relatively, muscle arthralgia, limbs be heavy, local to be sent out coolly, P value respectively＜0.001 and＜0.01 has highly significant difference, points out 1 group of medicine of observation that above-mentioned three symptom curative effects obviously are better than matched group.The swelling symptom, also there is significant difference P＜0.05, and its curative effect also is better than matched group.

2, observe 2 groups of clinical symptoms curative effects

Table 5 is observed 2 groups of each clinical symptoms curative effects

Symptom (sign)	Total example	Control preceding integration	Control the back integration	Drop-out value	Rate of descent (%)
						The heavy part of muscle arthralgia limbs sends out swelling cool	30 27 29 4	146 112 67 5	38 32 14 1	100 80 53 4	73.9 71.4 79.1 80.0

As seen from Table 5, observe 2 groups of treatments after, the muscle arthralgia, limbs are heavy, locally send out coolly, four symptom integral rates of descent of swelling are respectively 73.9%, 71.4%, 79.1%, 80%.Prompting observation group medicine has the curative effect of highly significant to above-mentioned four symptoms.

(3) observation group's medicine is to the influence of erythrocyte sedimentation rate and anti-chain indexs such as " O "

Anti-chain " O " is all more than 500 units before observing 1 group of treatment, and after the treatment, 38 examples have decline in various degree.The erythrocyte sedimentation rate meansigma methods is 26.06 ± 15.53 before the treatment, drops to 16.16 ± 8.92 after the treatment, and through the T check, there is significant differences P＜0.001, and prompting has obvious regulating action to erythrocyte sedimentation rate, and its mechanism remains further to be inquired into.

Six, toxic and side effects and untoward reaction

To having observed indexs such as routine blood test, routine urinalysis, liver function, renal function before and after observation group's case treatment, the result has no significant change, and it is safe using this medicine during the prompting treatment.In the clinical observation process, there are 5 examples skin itching to occur, 2 routine skin rubefaction, 1 routine skin has little pimple, is due to its plaster dressing rubber.

Seven, discussion and conclusion

(1) discusses

1, medicine dog skin plaster of the present invention carries out 80 routine clinical observations through hospitals such as Liaoning Prov. Traditional Chinese Medicine Inst, Shenyang Inst. of Traditional Chinese Medicine, rheumatic arthritis is belonged to syndrome of cold-dampness blocking collaterals type person, above percentage rate of its produce effects and total effective rate are respectively 32% and 90%, curative effect is obvious, be better than contrasting the medicine SHEXIANG ZHUANGGU GAO, cold rheumatoid joint pain belongs to syndrome of cold-dampness blocking collaterals type person significant curative effect, and above percentage rate of its produce effects and total effective rate are up to 63.3% and 96.6%.

2, heavy to muscle arthralgia, limbs, the local symptom such as cold of sending out of plaster has significant curative effect, and obviously is better than contrasting medicine.Arthroncus there is certain curative effect.

3, indexs such as this medicine antagonism chain " O " and erythrocyte sedimentation rate have certain regulating action, and its mechanism remains further to be inquired into.

4, paste with the curative effect of this ointment after 2 weeks and be better than curative effect after 1 week, prompting label with this medicine to be advisable more than 2 weeks.

5, this medicine is consistent to the different courses of disease, all ages and classes, different sexes patient's curative effect.

6, paste with this medicine except that skin itching, rubescent and have the little pimple appears in individual patient, do not have other side effect and untoward reaction, illustrate that this medicine of use is safe and reliable.

(2) conclusion

Clinical observation result shows: the curative effect that this medicine treatment rheumatic arthritis and cold rheumatoid joint pain belong to syndrome of cold-dampness blocking collaterals type person is significant, and obviously is better than contrasting medicine.This medicine of clinical use is safe and reliable.

The specific embodiment

Enforcement to Chinese medicine of the present invention is elaborated below, but protection scope of the present invention is not limit by embodiment.

Embodiment one:

A kind of have an expelling wind and cold, relaxing muscles and tendons to promote blood circulation, with the Chinese medicine of network pain-relieving functions, it is made up of the fractional component of following weight: Fructus Aurantii 700, Herba Asari 700, Halloysitum Rubrum 700, Caulis Sinomenii 700, Rhizoma Gastrodiae 700, Pericarpium Citri Reticulatae Viride 700, Rhizoma Et Radix Notopterygii 700, the Radix Linderae 700, Radix Aconiti 700, Radix Glycyrrhizae 700, Radix Ampelopsis 700, Cortex Phellodendri 700, Rhizoma Chuanxiong 1000, the Radix Aucklandiae 700, Radix Polygalae 700, Semen Persicae 700, the Rhizoma Atractylodis Macrocephalae 700, Radix Aconiti Kusnezoffii 700, Fructus Foeniculi 700, Squama Manis 700, Semen Cuscutae 700, Fructus Toosendan 700, Fructus Cnidii 700, Radix Clematidis 700, Semen Hydnocarpi 700, Radix Paeoniae Rubra 700, Radix Achyranthis Bidentatae 700, Fructus Psoraleae 700, Radix Dipsaci 700, Radix Aconiti Lateralis Preparata 700, the Cortex Eucommiae 700, Rhizoma Cyperi 700, Bombyx Batryticatus 700, Radix Angelicae Sinensis 700, Pericarpium Citri Reticulatae 700, Cortex Cinnamomi 1000, catechu 400, Olibanum 400, Sanguis Draxonis 400, Myrrha 400, Flos Caryophylli 400, Camphora 700, methyl salicylate 1200; very thin oily 2000; Borneolum Syntheticum 2000; diphhydramine hydrochloride 220; Semen daturae fluid extract 35; azone 200.

The preparation method that is made into special dog skin plaster is as follows: get Fructus Aurantii by described weight ratio, Herba Asari, Halloysitum Rubrum, Caulis Sinomenii, Rhizoma Gastrodiae, Pericarpium Citri Reticulatae Viride, Rhizoma Et Radix Notopterygii, the Radix Linderae, Radix Aconiti, Radix Glycyrrhizae, hold back in vain, Cortex Phellodendri, Rhizoma Chuanxiong, the Radix Aucklandiae, Radix Polygalae, Semen Persicae, the Rhizoma Atractylodis Macrocephalae, Radix Aconiti Kusnezoffii, Fructus Foeniculi, Squama Manis, Semen Cuscutae, Fructus Toosendan, Fructus Cnidii, Radix Clematidis, Semen Hydnocarpi, Radix Paeoniae Rubra, Radix Achyranthis Bidentatae, Fructus Psoraleae, Radix Dipsaci, Radix Aconiti Lateralis Preparata, the Cortex Eucommiae, Rhizoma Cyperi, Bombyx Batryticatus, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Cortex Cinnamomi, catechu, Olibanum, Sanguis Draxonis, Myrrha, Flos Caryophylli is ground into coarse powder, with alcohol reflux three times, 2-4 hour for the first time, second, three times 1-3 hour, merge three times extracting solution, being evaporated to relative density is that 1.30-1.35 is at the 65-70 ℃ of extractum of measuring down, standby, getting rubber cleans, dry down at 50-60 ℃, be cut into bulk, in rubber mixing machine, plasticate and reticulate thin slice, camphorate, Oleum menthae, the ice place, diphhydramine hydrochloride, methyl salicylate, the azone mixed liquor, flooded 18-30 hour, add above-mentioned extractum, Semen daturae fluid extract, roll evenly, be applied on the cloth, itemize, punching, the lid lining, section, packing, promptly.

Embodiment two:

A kind of have an expelling wind and cold, relaxing muscles and tendons to promote blood circulation, with the Chinese medicine of network pain-relieving functions, it is made up of the fractional component of following weight: Fructus Aurantii 300, Herba Asari 300, Halloysitum Rubrum 300, Caulis Sinomenii 300, Rhizoma Gastrodiae 300, Pericarpium Citri Reticulatae Viride 300, Rhizoma Et Radix Notopterygii 300, the Radix Linderae 300, Radix Aconiti 300, Radix Glycyrrhizae 300, Radix Ampelopsis 300, Cortex Phellodendri 300, the Radix Aucklandiae 300, Radix Polygalae 300, Semen Persicae 300, the Rhizoma Atractylodis Macrocephalae 300, Radix Aconiti Kusnezoffii 300, Fructus Foeniculi 300, Squama Manis 300, Semen Cuscutae 300, Fructus Toosendan 300, Fructus Cnidii 300, Radix Clematidis 300, Semen Hydnocarpi 300, Radix Paeoniae Rubra 300, Radix Achyranthis Bidentatae 300, Fructus Psoraleae 300, Radix Dipsaci 300, Radix Aconiti Lateralis Preparata 300, the Cortex Eucommiae 300, Rhizoma Cyperi 300, Bombyx Batryticatus 300, Radix Angelicae Sinensis 300, Pericarpium Citri Reticulatae 300, catechu 100, Olibanum 100, Sanguis Draxonis 100, Myrrha 100, Flos Caryophylli 100, Camphora 300, diphhydramine hydrochloride 80, Semen daturae fluid extract 8, azone 30.

Its preparation method is with embodiment one.

Embodiment three:

A kind of have an expelling wind and cold, relaxing muscles and tendons to promote blood circulation, with the Chinese medicine of network pain-relieving functions, it is made up of the fractional component of following weight: Fructus Aurantii 700, Herba Asari 700, Halloysitum Rubrum 300, Caulis Sinomenii 300, Rhizoma Gastrodiae 700, Pericarpium Citri Reticulatae Viride 300, Rhizoma Et Radix Notopterygii 700, the Radix Linderae 700, Radix Aconiti 300, Radix Glycyrrhizae 700, Radix Ampelopsis 700, Cortex Phellodendri 700, Rhizoma Chuanxiong 700, the Radix Aucklandiae 700, Radix Polygalae 300, Semen Persicae 300, the Rhizoma Atractylodis Macrocephalae 700, Radix Aconiti Kusnezoffii 700, Fructus Foeniculi 700, Squama Manis 700, Semen Cuscutae 700, Fructus Toosendan 700, Fructus Cnidii 700, Radix Clematidis 700, Semen Hydnocarpi 700, Radix Paeoniae Rubra 700, Radix Achyranthis Bidentatae 700, Fructus Psoraleae 300, Radix Dipsaci 300, Radix Aconiti Lateralis Preparata 300, the Cortex Eucommiae 700, Rhizoma Cyperi 700, Bombyx Batryticatus 300, Radix Angelicae Sinensis 700, Pericarpium Citri Reticulatae 700, Cortex Cinnamomi 300, catechu 100, Olibanum 400, Sanguis Draxonis 400, Myrrha 100, Flos Caryophylli 400, Camphora 700, methyl salicylate 1000; very thin oily 1500; Borneolum Syntheticum 600; diphhydramine hydrochloride 80; Semen daturae fluid extract 35; azone 30.

Embodiment four:

A kind of have an expelling wind and cold, relaxing muscles and tendons to promote blood circulation, with the Chinese medicine of network pain-relieving functions, it is made up of the fractional component of following weight: Fructus Aurantii 400, Herba Asari 400, Halloysitum Rubrum 400, Caulis Sinomenii 400, Rhizoma Gastrodiae 400, Pericarpium Citri Reticulatae Viride 400, Rhizoma Et Radix Notopterygii 400, the Radix Linderae 400, Radix Aconiti 400, Radix Glycyrrhizae 400, Radix Ampelopsis 400, Cortex Phellodendri 400, Rhizoma Chuanxiong 400, the Radix Aucklandiae 400, Radix Polygalae 400, Semen Persicae 400, the Rhizoma Atractylodis Macrocephalae 400, Radix Aconiti Kusnezoffii 400, Fructus Foeniculi 400, Squama Manis 400, Semen Cuscutae 400, Fructus Toosendan 400, Fructus Cnidii 400, Radix Clematidis 400, Semen Hydnocarpi 400, Radix Paeoniae Rubra 400, Radix Achyranthis Bidentatae 400, Fructus Psoraleae 400, Radix Dipsaci 400, Radix Aconiti Lateralis Preparata 400, the Cortex Eucommiae 400, Rhizoma Cyperi 400, Bombyx Batryticatus 400, Radix Angelicae Sinensis 400, Pericarpium Citri Reticulatae 400, Cortex Cinnamomi 400, catechu 200, Olibanum 200, Sanguis Draxonis 200, Myrrha 200, Flos Caryophylli 200, Camphora 400, methyl salicylate 550; very thin oily 900; Borneolum Syntheticum 900; diphhydramine hydrochloride 120; Semen daturae fluid extract 15; azone 30.

Embodiment five:

A kind of have an expelling wind and cold, relaxing muscles and tendons to promote blood circulation, with the Chinese medicine of network pain-relieving functions, it is made up of the fractional component of following weight: Fructus Aurantii 600, Herba Asari 600, Halloysitum Rubrum 600, Caulis Sinomenii 600, Rhizoma Gastrodiae 600, Pericarpium Citri Reticulatae Viride 600, Rhizoma Et Radix Notopterygii 600, the Radix Linderae 600, Radix Aconiti 600, Radix Glycyrrhizae 600, Radix Ampelopsis 600, Cortex Phellodendri 600, Rhizoma Chuanxiong 600, the Radix Aucklandiae 600, Radix Polygalae 600, Semen Persicae 600, the Rhizoma Atractylodis Macrocephalae 600, Radix Aconiti Kusnezoffii 600, Fructus Foeniculi 600, Squama Manis 600, Semen Cuscutae 600, Fructus Toosendan 600, Fructus Cnidii 600, Radix Clematidis 600, Semen Hydnocarpi 600, Radix Paeoniae Rubra 600, Radix Achyranthis Bidentatae 600, Fructus Psoraleae 600, Radix Dipsaci 600, Radix Aconiti Lateralis Preparata 600, the Cortex Eucommiae 600, Rhizoma Cyperi 600, Bombyx Batryticatus 600, Radix Angelicae Sinensis 600, Pericarpium Citri Reticulatae 600, Cortex Cinnamomi 600, catechu 300, Olibanum 300, Sanguis Draxonis 300, Myrrha 300, Flos Caryophylli 300, Camphora 600, methyl salicylate 850; very thin oily 1200; Borneolum Syntheticum 1200; diphhydramine hydrochloride 180; Semen daturae fluid extract 25; azone 100.

Embodiment six:

A kind of have an expelling wind and cold, relaxing muscles and tendons to promote blood circulation, with the Chinese medicine of network pain-relieving functions, it is made up of the fractional component of following weight: Fructus Aurantii 550, Herba Asari 650, Halloysitum Rubrum 500, Caulis Sinomenii 550, Rhizoma Gastrodiae 650, Pericarpium Citri Reticulatae Viride 650, Rhizoma Et Radix Notopterygii 650, the Radix Linderae 550, Radix Aconiti 500, Radix Glycyrrhizae 580, Radix Ampelopsis 680, Cortex Phellodendri 660, Rhizoma Chuanxiong 600, the Radix Aucklandiae 600, Radix Polygalae 600, Semen Persicae 600, the Rhizoma Atractylodis Macrocephalae 480, Radix Aconiti Kusnezoffii 480, Fructus Foeniculi 480, Squama Manis 480, Semen Cuscutae 480, Fructus Toosendan 600, Fructus Cnidii 600, Radix Clematidis 480, Semen Hydnocarpi 600, Radix Paeoniae Rubra 600, Radix Achyranthis Bidentatae 600, Fructus Psoraleae 480, Radix Dipsaci 600, Radix Aconiti Lateralis Preparata 480, the Cortex Eucommiae 600, Rhizoma Cyperi 600, Bombyx Batryticatus 600, Radix Angelicae Sinensis 600, Pericarpium Citri Reticulatae 600, Cortex Cinnamomi 600, catechu 250, Olibanum 220, Sanguis Draxonis 220, Myrrha 220, Flos Caryophylli 220, Camphora 460, methyl salicylate 680; very thin oily 180; Borneolum Syntheticum 220; diphhydramine hydrochloride 160; Semen daturae fluid extract 15.

Embodiment seven:

A kind of have an expelling wind and cold, relaxing muscles and tendons to promote blood circulation, with the Chinese medicine of network pain-relieving functions, it is made up of the fractional component of following weight: Fructus Aurantii 500, Herba Asari 500, Halloysitum Rubrum 500, Caulis Sinomenii 500, Rhizoma Gastrodiae 500, Pericarpium Citri Reticulatae Viride 500, Rhizoma Et Radix Notopterygii 500, the Radix Linderae 500, Radix Aconiti 500, Radix Glycyrrhizae 500, Radix Ampelopsis 500, Cortex Phellodendri 500, Rhizoma Chuanxiong 500, the Radix Aucklandiae 500, Radix Polygalae 500, Semen Persicae 500, the Rhizoma Atractylodis Macrocephalae 500, Radix Aconiti Kusnezoffii 500, Fructus Foeniculi 500, Squama Manis 500, Semen Cuscutae 500, Fructus Toosendan 500, Fructus Cnidii 500, Radix Clematidis 500, Semen Hydnocarpi 500, Radix Paeoniae Rubra 500, Radix Achyranthis Bidentatae 500, Fructus Psoraleae 500, Radix Dipsaci 500, Radix Aconiti Lateralis Preparata 500, the Cortex Eucommiae 500, Rhizoma Cyperi 500, Bombyx Batryticatus 500, Radix Angelicae Sinensis 500, Pericarpium Citri Reticulatae 500, Cortex Cinnamomi 500, catechu 250, Olibanum 250, Sanguis Draxonis 250, Myrrha 250, Flos Caryophylli 250, Camphora 500, methyl salicylate 700; very thin oily 1000; Borneolum Syntheticum 1000; diphhydramine hydrochloride 150; Semen daturae fluid extract 20; azone 60.

Embodiment eight:

A kind of have an expelling wind and cold, relaxing muscles and tendons to promote blood circulation, with the Chinese medicine of network pain-relieving functions, it is made up of the fractional component of following weight: Fructus Aurantii 500, Herba Asari 500, Halloysitum Rubrum 500, Caulis Sinomenii 450, Rhizoma Gastrodiae 500, Pericarpium Citri Reticulatae Viride 500, Rhizoma Et Radix Notopterygii 500, the Radix Linderae 450, Radix Aconiti 500, Radix Glycyrrhizae 500, Radix Ampelopsis 500, Cortex Phellodendri 500, Rhizoma Chuanxiong 500, the Radix Aucklandiae 500, Radix Polygalae 500, Semen Persicae 500, the Rhizoma Atractylodis Macrocephalae 450, Radix Aconiti Kusnezoffii 500, Fructus Foeniculi 500, Squama Manis 500, Semen Cuscutae 500, Fructus Toosendan 500, Fructus Cnidii 500, Radix Clematidis 500, Semen Hydnocarpi 500, Radix Paeoniae Rubra 500, Radix Achyranthis Bidentatae 450, Fructus Psoraleae 500, Radix Dipsaci 500, Radix Aconiti Lateralis Preparata 500, the Cortex Eucommiae 500, Rhizoma Cyperi 500, Bombyx Batryticatus 500, Radix Angelicae Sinensis 500, Pericarpium Citri Reticulatae 500, Cortex Cinnamomi 450, catechu 350, Olibanum 350, Sanguis Draxonis 250, Myrrha 250, Flos Caryophylli 250, Camphora 550, methyl salicylate 800; very thin oily 1100; Borneolum Syntheticum 1100; diphhydramine hydrochloride 110; Semen daturae fluid extract 18; azone 50.

Embodiment nine:

A kind of have an expelling wind and cold, relaxing muscles and tendons to promote blood circulation, with the Chinese medicine of network pain-relieving functions, it is made up of the fractional component of following weight: Fructus Aurantii 400, Herba Asari 400, Halloysitum Rubrum 400, Caulis Sinomenii 400, Rhizoma Gastrodiae 300, Pericarpium Citri Reticulatae Viride 300, Rhizoma Et Radix Notopterygii 300, the Radix Linderae 400, Radix Aconiti 350, Radix Glycyrrhizae 350, Radix Ampelopsis 400, Cortex Phellodendri 400, Rhizoma Chuanxiong 100, the Radix Aucklandiae 400, Radix Polygalae 400, Semen Persicae 400, the Rhizoma Atractylodis Macrocephalae 400, Radix Aconiti Kusnezoffii 300, Fructus Foeniculi 300, Squama Manis 300, Semen Cuscutae 300, Fructus Toosendan 300, Fructus Cnidii 300, Radix Clematidis 300, Semen Hydnocarpi 300, Radix Paeoniae Rubra 300, Radix Achyranthis Bidentatae 300, Fructus Psoraleae 300, Radix Dipsaci 300, Radix Aconiti Lateralis Preparata 300, the Cortex Eucommiae 300, Rhizoma Cyperi 300, Bombyx Batryticatus 300, Radix Angelicae Sinensis 300, Pericarpium Citri Reticulatae 300, Cortex Cinnamomi 200, catechu 400, Olibanum 400, Sanguis Draxonis 400, Myrrha 400, Flos Caryophylli 400, Camphora 400, methyl salicylate 120; very thin oily 1800; Borneolum Syntheticum 110; diphhydramine hydrochloride 220; Semen daturae fluid extract 35; azone 100.

Embodiment ten:

Azone described in the embodiment one to ten is a Percutaneous absorption enhancer, azone can be substituted by in dimethyl sulfoxide, alcohol, polyhydric alcohol, ethyl acetate, oleic acid, linoleic acid, lauric acid and ester thereof, azone, anion surfactant, cationic surfactant, non-ionic surface active agent, lecithin, carbamide, the salicylic acid pyrrolidone any one, and other is identical.

Claims (5)

1, a kind of have an expelling wind and cold, relaxing muscles and tendons to promote blood circulation, with the Chinese medicine of network pain-relieving functions, it is characterized in that its active component is made up of the fractional component of following weight: Fructus Aurantii 300-700, Herba Asari 300-700, Halloysitum Rubrum 300-700, Caulis Sinomenii 300-700, Rhizoma Gastrodiae 300-700, Pericarpium Citri Reticulatae Viride 300-700, Rhizoma Et Radix Notopterygii 300-700, Radix Linderae 300-700, Radix Aconiti 300-700, Radix Glycyrrhizae 300-700, Radix Ampelopsis 300-700, Cortex Phellodendri 300-700, Rhizoma Chuanxiong 0-1000, Radix Aucklandiae 300-700, Radix Polygalae 300-700, Semen Persicae 300-700, Rhizoma Atractylodis Macrocephalae 300-700, Radix Aconiti Kusnezoffii 300-700, Fructus Foeniculi 300-700, Squama Manis 300-700, Semen Cuscutae 300-700, Fructus Toosendan 300-700, Fructus Cnidii 300-700, Radix Clematidis 300-700, Semen Hydnocarpi 300-700, Radix Paeoniae Rubra 300-700, Radix Achyranthis Bidentatae 300-700, Fructus Psoraleae 300-700, Radix Dipsaci 300-700, Radix Aconiti Lateralis Preparata 300-700, Cortex Eucommiae 300-700, Rhizoma Cyperi 300-700, Bombyx Batryticatus 300-700, Radix Angelicae Sinensis 300-700, Pericarpium Citri Reticulatae 300-700, Cortex Cinnamomi 0-1000, catechu 100-400, Olibanum 100-400, Sanguis Draxonis 100-400, Myrrha 100-400, Flos Caryophylli 100-400, Camphora 300-700, methyl salicylate 0-1200; very thin oily 0-2000; Borneolum Syntheticum 0-2000; diphhydramine hydrochloride 80-220; Semen daturae fluid extract 8-35; Percutaneous absorption enhancer 0-200.

2, according to claim 1 have an expelling wind and cold, relaxing muscles and tendons to promote blood circulation, with the Chinese medicine of network pain-relieving functions, it is characterized in that active component is made up of the fractional component of following weight: Fructus Aurantii 400-600, Herba Asari 400-600, Halloysitum Rubrum 400-600, Caulis Sinomenii 400-600, Rhizoma Gastrodiae 400-600, Pericarpium Citri Reticulatae Viride 400-600, Rhizoma Et Radix Notopterygii 400-600, Radix Linderae 400-600, Radix Aconiti 400-600, Radix Glycyrrhizae 400-600, Radix Ampelopsis 400-600, Cortex Phellodendri 400-600, Rhizoma Chuanxiong 400-600, Radix Aucklandiae 400-600, Radix Polygalae 400-600, Semen Persicae 400-600, Rhizoma Atractylodis Macrocephalae 400-600, Radix Aconiti Kusnezoffii 400-600, Fructus Foeniculi 400-600, Squama Manis 400-600, Semen Cuscutae 400-600, Fructus Toosendan 400-600, Fructus Cnidii 400-600, Radix Clematidis 400-600, Semen Hydnocarpi 400-600, Radix Paeoniae Rubra 400-600, Radix Achyranthis Bidentatae 400-600, Fructus Psoraleae 400-600, Radix Dipsaci 400-600, Radix Aconiti Lateralis Preparata 400-600, Cortex Eucommiae 400-600, Rhizoma Cyperi 400-600, Bombyx Batryticatus 400-600, Radix Angelicae Sinensis 400-600, Pericarpium Citri Reticulatae 400-600, Cortex Cinnamomi 400-600, catechu 200-300, Olibanum 200-300, Sanguis Draxonis 200-300, Myrrha 200-300, Flos Caryophylli 200-300, Camphora 400-600, methyl salicylate 550-850; very thin oily 900-1200; Borneolum Syntheticum 900-1200; diphhydramine hydrochloride 120-180; Semen daturae fluid extract 15-25; Percutaneous absorption enhancer 30-100.

3, the Chinese medicine with expelling wind and cold, relaxing muscles and tendons to promote blood circulation and network pain-relieving functions according to claim 1 and 2 is characterized in that described Percutaneous absorption enhancer is any one in dimethyl sulfoxide, alcohol, polyhydric alcohol, ethyl acetate, oleic acid, linoleic acid, lauric acid and ester thereof, azone, anion surfactant, cationic surfactant, non-ionic surface active agent, lecithin, carbamide, the salicylic acid pyrrolidone.

4, according to claim 1 and 2 have an expelling wind and cold, relaxing muscles and tendons to promote blood circulation, with the Chinese medicine of network pain-relieving functions, it is characterized in that active component is made up of the fractional component of following weight: Fructus Aurantii 500, Herba Asari 500, Halloysitum Rubrum 500, Caulis Sinomenii 500, Rhizoma Gastrodiae 500, Pericarpium Citri Reticulatae Viride 500, Rhizoma Et Radix Notopterygii 500, the Radix Linderae 500, Radix Aconiti 500, Radix Glycyrrhizae 500, Radix Ampelopsis 500, Cortex Phellodendri 500, Rhizoma Chuanxiong 500, the Radix Aucklandiae 500, Radix Polygalae 500, Semen Persicae 500, the Rhizoma Atractylodis Macrocephalae 500, Radix Aconiti Kusnezoffii 500, Fructus Foeniculi 500, Squama Manis 500, Semen Cuscutae 500, Fructus Toosendan 500, Fructus Cnidii 500, Radix Clematidis 500, Semen Hydnocarpi 500, Radix Paeoniae Rubra 500, Radix Achyranthis Bidentatae 500, Fructus Psoraleae 500, Radix Dipsaci 500, Radix Aconiti Lateralis Preparata 500, the Cortex Eucommiae 500, Rhizoma Cyperi 500, Bombyx Batryticatus 500, Radix Angelicae Sinensis 500, Pericarpium Citri Reticulatae 500, Cortex Cinnamomi 500, catechu 250, Olibanum 250, Sanguis Draxonis 250, Myrrha 250, Flos Caryophylli 250, Camphora 500, methyl salicylate 700; very thin oily 1000; Borneolum Syntheticum 1000; diphhydramine hydrochloride 150; Semen daturae fluid extract 20; azone 60.

5, a kind of claim 1 is described to have expelling wind and cold, relaxing muscles and tendons to promote blood circulation, preparation method with the dog skin plaster of network pain-relieving functions Chinese medicine, get Fructus Aurantii by described weight ratio, Herba Asari, Halloysitum Rubrum, Caulis Sinomenii, Rhizoma Gastrodiae, Pericarpium Citri Reticulatae Viride, Rhizoma Et Radix Notopterygii, the Radix Linderae, Radix Aconiti, Radix Glycyrrhizae, hold back in vain, Cortex Phellodendri, Rhizoma Chuanxiong, the Radix Aucklandiae, Radix Polygalae, Semen Persicae, the Rhizoma Atractylodis Macrocephalae, Radix Aconiti Kusnezoffii, Fructus Foeniculi, Squama Manis, Semen Cuscutae, Fructus Toosendan, Fructus Cnidii, Radix Clematidis, Semen Hydnocarpi, Radix Paeoniae Rubra, Radix Achyranthis Bidentatae, Fructus Psoraleae, Radix Dipsaci, Radix Aconiti Lateralis Preparata, the Cortex Eucommiae, Rhizoma Cyperi, Bombyx Batryticatus, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Cortex Cinnamomi, catechu, Olibanum, Sanguis Draxonis, Myrrha, Flos Caryophylli is ground into coarse powder, with alcohol reflux three times, 2-4 hour for the first time, second, three times 1-3 hour, merge three times extracting solution, being evaporated to relative density is that 1.30-1.35 is at the 65-70 ℃ of extractum of measuring down, standby, getting rubber cleans, dry down at 50-60 ℃, be cut into bulk, in rubber mixing machine, plasticate and reticulate thin slice, camphorate, Oleum menthae, the ice place, diphhydramine hydrochloride, methyl salicylate, the Percutaneous absorption enhancer mixed liquor, flooded 18-30 hour, add above-mentioned extractum, Semen daturae fluid extract, roll evenly, be applied on the cloth, itemize, punching, the lid lining, section, packing, promptly.