CN1899471A - External use muscle relaxing preparation for treating traumatic injury and rheumatism stagnation pain and its preparing method - Google Patents
External use muscle relaxing preparation for treating traumatic injury and rheumatism stagnation pain and its preparing method Download PDFInfo
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Abstract
The externally applied muscle relaxing preparation is prepared with 16 kinds of Chinese medicinal materials, including wild aconite root, red peony root, camphor, pricklyash, rhubarb, etc. It has the functions of relaxing and activating tendons, dispelling wind and dampness, healing wound and stopping pain, and is applied in treating rheumatic arthralgia, traumatic injury, myalgia and limitation of movement. It has obvious curative effect and no obvious toxic side effect.
Description
Technical field: the present invention relates to a kind of external use muscle relaxing preparation for the treatment of traumatic injury, rheumatic arthralgia and preparation method thereof, belong to technical field of traditional Chinese medicine pharmacy.
Background technology: traumatic injury causes muscles, tendon and vessel injury, causes disorder of QI movement, the QI and blood mutual resistance, and stagnation of QI and blood, passages through which vital energy circulates is obstructed, and diseases such as local swelling, joint stuffiness, limitation of activity are then arranged; Often because of the wind-cold damp pathogen invasion and attack, multiple abscess muscle, joint, passages through which vital energy circulates make coagulation of QI-blood not all right to the rheumatic arthralgia person, then have muscle arthralgia, swelling or numb limbs and tense tendons emphatically, diseases such as limitation of activity.Existing bone-setting liquor and DIEDA WANHUAYOU are usually used in the cold and damp stagnation card on the market, and bone-setting liquor is usually used in fracture and wet blood stasis syndrome, restrains grieved aerosol and YUNNAN BAIYAO DING and is usually used in syndrome of static blood blocking collaterals.And yet there are no open to the traumatic injury of syndrome of static blood blocking collaterals and all medicable medicine of rheumatic ostalgia of cold and damp stagnation card simultaneously.
Summary of the invention:
The objective of the invention is to: a kind of external use muscle relaxing preparation for the treatment of traumatic injury, rheumatic arthralgia and preparation method thereof is provided, and the present invention is a raw material with pure Chinese herbal medicine, has expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral, the analgesic effect of curing the wound is used for wind-damp numbness, traumatic injury, bones and muscles pain, joint stuffiness; It is evident in efficacy, and steady quality is easy to use.
The present invention constitutes like this: according to listed as parts by weight, it is to make for 40～80 parts with 40～80 parts of Radix Aconiti Kusnezoffii, 20～40 parts of Radix Paeoniae Rubra, 40～80 parts of Camphoras, 40～80 parts in Pericarpium Zanthoxyli, 40～80 parts of Radix Et Rhizoma Rhei, 40～80 parts of Radix Aconiti, 40～80 parts of Rhizoma Pinelliae, 20～40 parts on Flos Carthami, 40～80 parts of Radix Angelicae Pubescentiss, 40～80 parts of Arisaema Cum Bile, 40～80 parts of Fructus Chaenomeliss, 40～80 parts of Fructus Gardeniaes, 30～60 parts of Pollen Typhaes, 30～60 parts of Lignum Sappans, 40～80 parts of Fructus Liquidambaris and Rhizoma Et Radix Notopterygii.
Specifically, it is to make with Radix Aconiti Kusnezoffii 60g, Radix Paeoniae Rubra 30g, Camphora 60g, Pericarpium Zanthoxyli 60g, Radix Et Rhizoma Rhei 60g, Radix Aconiti 60g, Rhizoma Pinelliae 60g, Flos Carthami 30g, Radix Angelicae Pubescentis 60g, Arisaema Cum Bile 60g, Fructus Chaenomelis 60g, Fructus Gardeniae 60g, Pollen Typhae 45g, Lignum Sappan 45g, Fructus Liquidambaris 60g and Rhizoma Et Radix Notopterygii 60g.
The present invention treats traumatic injury, the preparation method of the external use muscle relaxing preparation of rheumatic arthralgia is: take by weighing Radix Aconiti Kusnezoffii, Radix Paeoniae Rubra, Pericarpium Zanthoxyli, Radix Et Rhizoma Rhei, Radix Aconiti, Rhizoma Pinelliae, Flos Carthami, Radix Angelicae Pubescentis, Arisaema Cum Bile, Fructus Chaenomelis, Fructus Gardeniae, Pollen Typhae, Lignum Sappan, Fructus Liquidambaris and Rhizoma Et Radix Notopterygii be totally ten five tastes, be ground into coarse powder, according to the percolation under Chinese Pharmacopoeia version appendix IO fluid extract in 2005 and the extractum item, make solvent with 50～70% ethanol, flood after 24～60 hours, with the speed of per minute 1～10ml percolation slowly, the collection liquid of filtering, after the stirring and dissolving that camphorates, filter, promptly get tincture of the present invention or fluid extract or extractum.
Best preparation method is: take by weighing Radix Aconiti Kusnezoffii, Radix Paeoniae Rubra, Pericarpium Zanthoxyli, Radix Et Rhizoma Rhei, Radix Aconiti, Rhizoma Pinelliae, Flos Carthami, Radix Angelicae Pubescentis, Arisaema Cum Bile, Fructus Chaenomelis, Fructus Gardeniae, Pollen Typhae, Lignum Sappan, Fructus Liquidambaris and Rhizoma Et Radix Notopterygii totally ten five tastes, be ground into coarse powder, according to the percolation under Chinese Pharmacopoeia version appendix IO fluid extract in 2005 and the extractum item, make solvent with 60% ethanol, flood after 48 hours, with the speed of per minute 1～3ml percolation slowly, the collection liquid of filtering, after the stirring and dissolving that camphorates, filter, promptly get tincture of the present invention or fluid extract or extractum.
The external use muscle relaxing preparation that the present invention treats traumatic injury, rheumatic arthralgia can also prepare like this: take by weighing Radix Aconiti Kusnezoffii, Radix Paeoniae Rubra, Camphora, Pericarpium Zanthoxyli, Radix Et Rhizoma Rhei, Radix Aconiti, Rhizoma Pinelliae, Flos Carthami, Radix Angelicae Pubescentis, Arisaema Cum Bile, Fructus Chaenomelis, Fructus Gardeniae, Pollen Typhae, Lignum Sappan, Fructus Liquidambaris and Rhizoma Et Radix Notopterygii totally ten Six-elements, pulverize, mix, promptly get active ingredient of the present invention, the active ingredient that obtains is added required adjuvant, make required preparation according to a conventional method.
The unguentum that the present invention treats traumatic injury, rheumatic arthralgia prepares like this: take by weighing Radix Aconiti Kusnezoffii, Radix Paeoniae Rubra, Camphora, Pericarpium Zanthoxyli, Radix Et Rhizoma Rhei, Radix Aconiti, Rhizoma Pinelliae, Flos Carthami, Radix Angelicae Pubescentis, Arisaema Cum Bile, Fructus Chaenomelis, Fructus Gardeniae, Pollen Typhae, Lignum Sappan, Fructus Liquidambaris and Rhizoma Et Radix Notopterygii totally ten Six-elements, be crushed to 100～300 orders, mixing, add one or more mixing in an amount of vaseline, paraffin, Polyethylene Glycol, Cera Flava, the lanoline, promptly.
The paste that the present invention treats traumatic injury, rheumatic arthralgia prepares like this: take by weighing Radix Aconiti Kusnezoffii, Radix Paeoniae Rubra, Camphora, Pericarpium Zanthoxyli, Radix Et Rhizoma Rhei, Radix Aconiti, Rhizoma Pinelliae, Flos Carthami, Radix Angelicae Pubescentis, Arisaema Cum Bile, Fructus Chaenomelis, Fructus Gardeniae, Pollen Typhae, Lignum Sappan, Fructus Liquidambaris and Rhizoma Et Radix Notopterygii totally ten Six-elements, pulverize the back and cross 80～100 mesh sieves, add an amount of glycerin gelatine then or the PEG class is made substrate, promptly.
The liniment that the present invention treats traumatic injury, rheumatic arthralgia prepares like this: take by weighing Radix Aconiti Kusnezoffii, Radix Paeoniae Rubra, Camphora, Pericarpium Zanthoxyli, Radix Et Rhizoma Rhei, Radix Aconiti, Rhizoma Pinelliae, Flos Carthami, Radix Angelicae Pubescentis, Arisaema Cum Bile, Fructus Chaenomelis, Fructus Gardeniae, Pollen Typhae, Lignum Sappan, Fructus Liquidambaris and Rhizoma Et Radix Notopterygii totally ten Six-elements, pulverize, use 60% alcohol dipping, stir once every day, filter, filtrate adds 60% ethanol to 10000ml, promptly.
Traumatic injury and the rheumatic arthralgia cause of disease, clinical manifestation are not quite similar, but similar pathogenesis is arranged, and promptly QI and blood blocks in passages through which vital energy circulates, numbness and obstructed.According to the principle for the treatment of different diseases with the same therapeutic principle, the ruling by law that both all can " declare logical " it, promptly controlling should the blood stasis dispelling circulation of qi promoting, reducing swelling and alleviating pain, the method for relaxing muscles and tendons and activating QI and blood in the collateral, passages through which vital energy circulates general rule distending pain remove.It is monarch drug that the present invention writes out a prescription with Radix Aconiti Kusnezoffii, Radix Aconiti, gets the merit of its relaxing muscles and tendons and activating flow of qi and blood channels and collaterals, and expelling, is ministerial drug with multi-flavor collateral dredging promoting blood circulation by removing wind medicines such as Pericarpium Zanthoxyli, Radix Et Rhizoma Rhei, Fructus Gardeniae, Arisaema Cum Bile, Rhizoma Pinelliae, Radix Angelicae Pubescentiss, and the monarch and his subjects mutually 5, and blood is capable and muscle relaxes, and wind removes and venation is lived.General rule not bitterly, the muscle network that relaxes is lived pain from disappearing.Help the merit that helps the monarch and his subjects with medicines such as Pericarpium Zanthoxyli, Camphora, Fructus Chaenomelis, Lignum Sappan, Rhizoma Et Radix Notopterygii, Fructus Liquidambaris again.More than all medicines share, play relaxing muscles and tendons and activating QI and blood in the collateral altogether, expelling wind and removing dampness, the merit of the pain relieving of curing the wound.Be used for wind-damp numbness, traumatic injury, bones and muscles pain, joint stuffiness cures mainly and sprains, tired damage, muscles and bones is ached.
In order to verify that medicine of the present invention has excellent curative, the applicant has carried out series of experimental research, and is specific as follows:
One, pharmacological toxicology test:
1. antiinflammatory action
1.1 on Carrageenan causes the influence of rat toes and gets 40 of male rats, body weight 150～180g is divided into 4 groups at random, and 8 every group, grouping and dosage saw Table for 1 (dosage contains the crude drug amount in every 1ml, and wherein 0.87g/ml is clinical consumption concentration).Successive administration four days, every day 3 times, 30min after the last administration, the toes aponeurosis (aponeuroses) is injected 1% carrageenin 0.05% down in a rat left side, with capillary tube measurement by magnification device, surveying the following partial volume in rat hindlimb ankle joint fixed position every 1h, is the swelling degree with the difference of medication front and back, METHOD FOR CONTINUOUS DETERMINATION 6 times, organize a t check, the result: each time of external use muscle relaxing tincture high dose mensuration all has tangible antiinflammatory action, and middle dosage 2h is effective, low dosage is not obvious, sees Table 1.
Table 1 on Carrageenan causes the n=8 that influences of rat toes swelling
| Group | Dosage (g/ml) | Cause scorching back rat toes swelling degree and change (X ± SDml) | |||||
| 1h | 2h | 3h | 4h | 5h | 6h | ||
| The external use muscle relaxing tincture | 1.74 | 0.05±0.039 *** | 0.136±0.089 *** | 0.227±0.168 *** | 0.374±0.128 *** | 0.408±0.119 ** | 0.447±0.091 *** |
| 0.87 | 0.146±0.054 * | 0.384±0.134 * | 0.654±0.162 | 0.732±0.154 | 0.684±0.158 | 0.682±0.143 | |
| 0.43 | 0.159±0.083 | 0.474±0.218 | 0.550±0.234 | 0.643±0.161 | 0.643±0.153 | 0.631±0.179 | |
| Bone-setting liquor | Clinical consumption | 0.158±0.193 | 0.240±0.078 * | 0.482±0.097 | 0.579±0.087 | 0.659±0.127 | 0.691±0.145 |
| (water) | Deng number of times | 0.246±0.113 | 0.576±0.198 | 0.713±0.137 | 0.760±0.142 | 0.633±0.138 | 0.688±0.114 |
*P＜0.05 **P＜0.01 ***P＜0.001
1.2 xylol causes the influence of Mice Auricle inflammation
Get 28 ± 2g male mice, 50, be divided into five groups at random, 10 every group.Matched group is given the equal-volume normal saline, and positive controls is given aspirin, and the administration volume is 0.15ml/10g.Test and be administered once earlier in preceding 16 hours, be administered once next day again, and after the administration 30 minutes for the second time, every Mus left side ear was coated with dimethylbenzene 30ul and causes inflammation, cause scorching back 1.5h, mice is put to death, cut two ears, take off the disk at the same position of two ears with the 8mm card punch, precision is weighed, with left and right sides ear weight difference is the swelling degree, compares with matched group, the results are shown in Table 2.
Table 2 external xylol cause mice auricle swelling influence (X ± SD, n=10)
| Group | Number of animals (only) | Dosage (g/ml) | Swelling degree (mg) |
| Matched group | 10 | In appearance water | 10.8±2.6 |
| Low dosage | 10 | 0.43 | 8.4±1.2* |
| Middle dosage | 10 | 0.87 | 6.8±2.6** |
| High dose | 10 | 1.74 | 5.2±3.8** |
| Aspirin | 10 | 0.15ml/10g | 5.0±3.1*** |
Annotate: compare * * * P＜0.001 * * P＜0.01 * P＜0.05 with matched group
The result shows: the Mice Auricle inflammation that external use muscle relaxing tincture xylol causes has significant inhibitory effect.
2. hot-plate analgesic test
Get 60 of female mices, each one is placed on the hot plate (hot plate temperature being transferred at 55 ± 1 ℃ in advance), and mice is from being placed on the hot plate to the pain threshold of metapedes required time (second) as this Mus occurring licking, i.e. response latency bitterly.Allly lick the metapedes time less than 5 seconds or give it up greater than 30 seconds or leaper.Qualified mice is divided into 5 groups at random, repeats to survey its normal pain threshold, the meansigma methods of getting two subnormal pain thresholds is as the pain threshold before this Mus administration (pain response latency).In experiment preceding 16 hours be administered once earlier (sole administration), experiment day is administered once again, and the administration volume is 0.15ml/10g.30min, 60min, 90min survey the pain threshold (pain response latency) of mice respectively after administration.Still reactionless as 60 seconds, mice is taken out, in order to avoid scald, calculated with 60 seconds its threshold of pain.The results are shown in Table 3.
Table 3 external use muscle relaxing tincture to the analgesic test (hot plate method) of mice (X ± SD, n=10)
| Group | Dosage (g/ml) | The pain response latency (s) before the administration | The pain response latency (s) of different time after the administration | ||
| 30min | 60min | 90min | |||
| Negative control group | Equal-volume water | 18.8±4.0 | 17.9±6.2 | 19.2±4.9 | 18.6±4.6 |
| Low dose group | 0.43 | 18.3±4.9 | 20.1±5.4 | 25.2±6.0* | 28.2±7.3** |
| Middle dosage group | 0.87 | 21.5±2.6 | 23.7±2.8 | 29.0±8.1* | 34.8±11.5** |
| High dose group | 1.74 | 19.1±3.5 | 22.5±3.8* | 27.2±5.6** | 33.7±11.6** |
| Aspirin | 0.01 | 20.7±2.8 | 29.1±7.2** | 36.9±12.0*** | 37.2±13.4** |
Annotate: compare * * P＜0.01 * P＜0.05 with matched group
The result shows: the external use muscle relaxing tincture causes pain to hot plate analgesic activity preferably.
3. skin irritation sensitivity test
Get 5 of rats, use the external use muscle relaxing tincture with 3 dosage (concentration) respectively: 1.74g/ml, 0.87g/ml, 0.43g/ml contact intact skin, with 2 dosage: 0.87g/ml, 1.74g/ml contact damage skin, observed 7 days continuously after 24 hours, there is no the reaction of whole body and local toxicity, anaphylaxis, administration district skin does not have erythema, no edema occurs.
Two, clinical trial
The external use muscle relaxing tincture is the new drug that my company develops according to folk remedy, has expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral, and the analgesic effect of curing the wound is used for wind-damp numbness, traumatic injury, bones and muscles pain, joint stuffiness.From year April in July, 2002 to 2003 to 100 routine extremity soft tissue injury patients, carried out clinical research according to the pairing of different severity extents and age stratification, the single blind contrast method at random of utilization, be reported as follows:
1. physical data: 50 examples are organized in treatment, matched group 50 examples; Man's 56 examples, women 44 examples, two groups are compared X
2=0.1532, P＞0.05; The oldest 60 years old, minimum 18 years old, average 35.35 years old, wherein less than 30 years old 38 example, 31～45 years old 25 example, 46～60 years old 37 example, two groups are relatively, U=0.3341, P＞0.05; Ill 1 all 69 examples, ill 2 all 24 examples, ill 3 all 7 examples, two groups are relatively, X
2=1.6764, P＞0.05; Upper limb 26 examples, lower limb 37 examples, waist 14 examples, cervical region 23 examples; Slight 27 examples, moderate 40 examples, severe 33 examples, two groups are relatively, U=0, P＞0.05.
The external use muscle relaxing tincture is embrocated the affected part in right amount, 2～3 times on the one, 7 days one courses of treatment, carries out statistical summary after the course of treatment; Matched group bone-setting liquor, usage are to spread on the affected part, 2～3 times on the one with the drenched absorbent cotton of medicinal liquid.Two groups during medication, all stop using other oral medicine and medicine for external use.
2. observation index
(1) degree of disease sites pain, tenderness and swelling, the scope of function limitation, the situation of muscle spasm.(2) blood, urine, stool routine examination, hepatic and renal function and Electrocardioscopy.(3) skin allergy and the intestines and stomach reaction.(4) spirit and neural situation of change.
3. severity extent assessment
(1) pain: be difficult to stand 3 fens, can stand 2 fens, slight 1 minute.(2) swelling: compare＞1cm3 branch with the Zhou Jing of strong side same area; 0.5～1cm2 branch;＜0.5cm1 branch.(3) pain: light pressed promptly pain or tenderness 3 minutes; Tenderness did not have tenderness 2 minutes; Tenderness need be exerted oneself 1 fen.(4) muscle spasm: as tabular, elasticity disappeared 3 fens; Poor flexibility 2 minutes: spasm slightly, elasticity can 1 minute.(5) dysfunction: joint motion reduces above 3 minutes of 30 degree; 30～20 degree 2 minutes; Following 1 minute of 20 degree.Severity extent is divided into gently, in, weigh three degree: 1～7 is divided into slightly, and 8～12 are divided into moderate, and 13～18 are divided into severe.
4. curative effect judging standard
(1) clinical cure: the sings and symptoms complete obiteration, treatment back total mark reduces greater than 95%.(2) produce effects: sings and symptoms is clearly better, and treatment back total mark reduces greater than 70%.(3) effective: sings and symptoms improves, and treatment back total mark reduces greater than 30%.(4) invalid: sings and symptoms does not have obvious improvement, and treatment back total mark reduces less than 30%.
4.1 diagnostic criteria
With the diagnostic criteria as research such as the miserable discomfort of body corresponding site, pain, swelling, tenderness, muscle spasm, dysfunction.
4.2 exclusion standard (1) under-18s, more than 60 years old, gestation or women breast-feeding their children have allergies person to external used medicine.(2) suffer from disease patients such as the heart, liver, kidney and disease of hematopoietic system, psychosis, tuberculosis, tumor.(3) be associated with fracture and other visceral organ injuries, cerebral trauma person.(4) not medication in accordance with regulations can't judge that curative effect or data are incomplete, affects the treatment and safety judgement person.
5. therapeutic outcome
5.1 result of study shows: the cure rate of treatment group is 46.00%, and obvious effective rate is 78.00%; The matched group cure rate is 20.00%, obvious effective rate 46.00%, and the treatment group obviously is better than matched group, sees table 4 for details.
The analysis of table 4 total effects
| Group | The example number | Clinical recovery | Produce effects | Effectively | Invalid | The U value | The P value |
| Test group | 50 | 23 | 16 | 9 | 2 | 3.3325 | ＜0.01 |
| Matched group | 50 | 10 | 13 | 20 | 7 |
5.2 two groups of individual event curative effects of individual event disease curative effect relatively
The result shows that the treatment group is better than matched group (all P＜0.01) aspect improving in diseases such as pain, swelling, tenderness, muscle spasm, dysfunctions, and before and after the treatment of the disease of two groups of each individual events highly significant difference (P＜0.05) is arranged more all, sees table 5 for details.
Table 5 individual event symptom efficacy analysis average integral (X ± SD)
| Project | Group | Before the treatment | After the treatment |
| Pain and swelling tenderness muscle cramp dysfunction | Treatment group treatment of control group group treatment of control group group treatment of control group group treatment of control group group control group | 2.42±0.53* 2.35±0.45 2.12±0.57* 2.41±0.59 2.54±1.14* 2.48±0.83 1.52±1.14* 1.28±0.85 1.53±0.98* 1.45±0.96 | 0.56±0.68** 1.10±0.76 0.29±0.51** 1.23±0.79 0.27±0.57** 1.26±0.79 0.16±0.34** 0.59±0.76 0.17±0.43** 0.54±0.62 |
* zero difference between P＞preceding each symptom treatment group of 0.05 expression treatment and matched group is variant between * * P＜0.05 expression treatment each symptom treatment group of back and matched group.
5.3 severity extent and curative effect
Different severity extents and curative effect relatively at slight group no significant difference, have notable difference in moderate and severe group between treatment group and the matched group between two groups, (P＜0.05,＜0.01), see table 6 for details.
Table 6 severity extent and therapeutic effect relationship analysis
| Degree | Group | Clinical cure | Produce effects | Effectively | Invalid | Add up to | Show more rate % | Ridit |
| Slight moderate severe | Treatment group treatment of control group group treatment of control group group matched group | 6 5 11 4 6 1 | 5 4 5 6 6 3 | 1 2 4 8 4 10 | 0 0 1 3 1 4 | 12 11 21 21 17 18 | 91.67 81.82 90 55 80.95 33.33 | U＝0.3772 P＞0.05 U＝2.2399 P＜0.05 U＝2.7783 P＜0.01 |
6. safety is observed
In the clinical research process, 25 examples that treatment is organized in 50 examples detections such as routine blood test, defecation routine, hepatic and renal function and electrocardiogram have been done before and after medication, the result is all in normal range, all case does not have skin allergy, gastrointestinal reaction, spirit and neural unusual performance in therapeutic process.Illustrate that external use muscle relaxing tincture of the present invention does not have overt toxicity reaction and side effect, safe and reliable, can life-time service.
Compared with prior art, preparation of the present invention has relaxing muscles and tendons and activating QI and blood in the collateral, expelling wind and removing dampness, the analgesic effect of curing the wound, clinical practice be in wind-damp numbness, traumatic injury, bones and muscles pain, joint stuffiness, it is evident in efficacy, no obvious toxic-side effects, safe and reliable, easy to use, stable and controllable for quality, be worth clinical application.
The specific embodiment:
Embodiments of the invention 1: Radix Aconiti Kusnezoffii 60g, Radix Paeoniae Rubra 30g, Camphora 60g, Pericarpium Zanthoxyli 60g, Radix Et Rhizoma Rhei 60g, Radix Aconiti 60g, Rhizoma Pinelliae 60g, Flos Carthami 30g, Radix Angelicae Pubescentis 60g, Arisaema Cum Bile 60g, Fructus Chaenomelis 60g, Fructus Gardeniae 60g, Pollen Typhae 45g, Lignum Sappan 45g, Fructus Liquidambaris 60g, Rhizoma Et Radix Notopterygii 60g
Take by weighing Radix Aconiti Kusnezoffii, Radix Paeoniae Rubra, Pericarpium Zanthoxyli, Radix Et Rhizoma Rhei, Radix Aconiti, Rhizoma Pinelliae, Flos Carthami, Radix Angelicae Pubescentis, Arisaema Cum Bile, Fructus Chaenomelis, Fructus Gardeniae, Pollen Typhae, Lignum Sappan, Fructus Liquidambaris and Rhizoma Et Radix Notopterygii totally ten five tastes, be ground into coarse powder, according to the percolation under Chinese Pharmacopoeia version appendix IO fluid extract in 2005 and the extractum item, make solvent with 60% ethanol, flood after 48 hours, with the speed of per minute 1～3ml percolation slowly, the collection liquid of filtering, after the stirring and dissolving that camphorates, filter, promptly get tincture of the present invention.The affected part is embrocated in the external of this preparation in right amount, 2～3 times on the one.
Embodiments of the invention 2: Radix Aconiti Kusnezoffii 40g, Radix Paeoniae Rubra 20g, Camphora 40g, Pericarpium Zanthoxyli 40g, Radix Et Rhizoma Rhei 40g, Radix Aconiti 40g, Rhizoma Pinelliae 40g, Flos Carthami 20g, Radix Angelicae Pubescentis 40g, Arisaema Cum Bile 40g, Fructus Chaenomelis 40g, Fructus Gardeniae 40g, Pollen Typhae 30g, Lignum Sappan 30g, Fructus Liquidambaris 40g, Rhizoma Et Radix Notopterygii 40g
Take by weighing Radix Aconiti Kusnezoffii, Radix Paeoniae Rubra, Pericarpium Zanthoxyli, Radix Et Rhizoma Rhei, Radix Aconiti, Rhizoma Pinelliae, Flos Carthami, Radix Angelicae Pubescentis, Arisaema Cum Bile, Fructus Chaenomelis, Fructus Gardeniae, Pollen Typhae, Lignum Sappan, Fructus Liquidambaris and Rhizoma Et Radix Notopterygii totally ten five tastes, be ground into coarse powder, according to the percolation under Chinese Pharmacopoeia version appendix IO fluid extract in 2005 and the extractum item, make solvent with 50% ethanol, flood after 24 hours, with the speed of per minute 3～10ml percolation slowly, the collection liquid of filtering, after the stirring and dissolving that camphorates, filter, promptly get fluid extract of the present invention.
Embodiments of the invention 3: Radix Aconiti Kusnezoffii 80g, Radix Paeoniae Rubra 40g, Camphora 80g, Pericarpium Zanthoxyli 80g, Radix Et Rhizoma Rhei 80g, Radix Aconiti 80g, Rhizoma Pinelliae 80g, Flos Carthami 40g, Radix Angelicae Pubescentis 80g, Arisaema Cum Bile 80g, Fructus Chaenomelis 80g, Fructus Gardeniae 80g, Pollen Typhae 60g, Lignum Sappan 60g, Fructus Liquidambaris 80g, Rhizoma Et Radix Notopterygii 80g
Take by weighing Radix Aconiti Kusnezoffii, Radix Paeoniae Rubra, Pericarpium Zanthoxyli, Radix Et Rhizoma Rhei, Radix Aconiti, Rhizoma Pinelliae, Flos Carthami, Radix Angelicae Pubescentis, Arisaema Cum Bile, Fructus Chaenomelis, Fructus Gardeniae, Pollen Typhae, Lignum Sappan, Fructus Liquidambaris and Rhizoma Et Radix Notopterygii totally ten five tastes, be ground into coarse powder, according to the percolation under Chinese Pharmacopoeia version appendix IO fluid extract in 2005 and the extractum item, make solvent with 70% ethanol, flood after 60 hours, with the speed of per minute 1～3ml percolation slowly, the collection liquid of filtering, after the stirring and dissolving that camphorates, filter, promptly get extractum of the present invention.
Embodiments of the invention 4: Radix Aconiti Kusnezoffii 40g, Radix Paeoniae Rubra 40g, Camphora 40g, Pericarpium Zanthoxyli 80g, Radix Et Rhizoma Rhei 40g, Radix Aconiti 80g, Rhizoma Pinelliae 40g, Flos Carthami 40g, Radix Angelicae Pubescentis 40g, Arisaema Cum Bile 80g, Fructus Chaenomelis 40g, Fructus Gardeniae 80g, Pollen Typhae 30g, Lignum Sappan 60g, Fructus Liquidambaris 40g, Rhizoma Et Radix Notopterygii 80g
Take by weighing Radix Aconiti Kusnezoffii, Radix Paeoniae Rubra, Camphora, Pericarpium Zanthoxyli, Radix Et Rhizoma Rhei, Radix Aconiti, Rhizoma Pinelliae, Flos Carthami, Radix Angelicae Pubescentis, Arisaema Cum Bile, Fructus Chaenomelis, Fructus Gardeniae, Pollen Typhae, Lignum Sappan, Fructus Liquidambaris and Rhizoma Et Radix Notopterygii totally ten Six-elements, be crushed to 100～300 orders, mixing adds an amount of vaseline and mixes, and promptly gets unguentum of the present invention.
Embodiments of the invention 5: Radix Aconiti Kusnezoffii 80g, Radix Paeoniae Rubra 20g, Camphora 80g, Pericarpium Zanthoxyli 40g, Radix Et Rhizoma Rhei 80g, Radix Aconiti 40g, Rhizoma Pinelliae 80g, Flos Carthami 20g, Radix Angelicae Pubescentis 80g, Arisaema Cum Bile 40g, Fructus Chaenomelis 80g, Fructus Gardeniae 40g, Pollen Typhae 60g, Lignum Sappan 30g, Fructus Liquidambaris 80g, Rhizoma Et Radix Notopterygii 40g
Take by weighing Radix Aconiti Kusnezoffii, Radix Paeoniae Rubra, Camphora, Pericarpium Zanthoxyli, Radix Et Rhizoma Rhei, Radix Aconiti, Rhizoma Pinelliae, Flos Carthami, Radix Angelicae Pubescentis, Arisaema Cum Bile, Fructus Chaenomelis, Fructus Gardeniae, Pollen Typhae, Lignum Sappan, Fructus Liquidambaris and Rhizoma Et Radix Notopterygii totally ten Six-elements, pulverize the back and cross 80～100 mesh sieves, add an amount of substrate (glycerin gelatine) then, promptly get paste of the present invention.
Embodiments of the invention 6: Radix Aconiti Kusnezoffii 40g, Radix Paeoniae Rubra 40g, Camphora 40g, Pericarpium Zanthoxyli 40g, Radix Et Rhizoma Rhei 40g, Radix Aconiti 40g, Rhizoma Pinelliae 40g, Flos Carthami 40g, Radix Angelicae Pubescentis 40g, Arisaema Cum Bile 40g, Fructus Chaenomelis 40g, Fructus Gardeniae 40g, Pollen Typhae 40g, Lignum Sappan 40g, Fructus Liquidambaris 40g, Rhizoma Et Radix Notopterygii 40g
Take by weighing Radix Aconiti Kusnezoffii, Radix Paeoniae Rubra, Camphora, Pericarpium Zanthoxyli, Radix Et Rhizoma Rhei, Radix Aconiti, Rhizoma Pinelliae, Flos Carthami, Radix Angelicae Pubescentis, Arisaema Cum Bile, Fructus Chaenomelis, Fructus Gardeniae, Pollen Typhae, Lignum Sappan, Fructus Liquidambaris and Rhizoma Et Radix Notopterygii totally ten Six-elements, pulverize, use 60% alcohol dipping, stir once every day, filter, filtrate adds 60% ethanol to 10000ml, promptly gets liniment of the present invention.
Claims (8)
1. external use muscle relaxing preparation for the treatment of traumatic injury, rheumatic arthralgia, it is characterized in that: according to listed as parts by weight, it is to make for 40～80 parts with 40～80 parts of Radix Aconiti Kusnezoffii, 20～40 parts of Radix Paeoniae Rubra, 40～80 parts of Camphoras, 40～80 parts in Pericarpium Zanthoxyli, 40～80 parts of Radix Et Rhizoma Rhei, 40～80 parts of Radix Aconiti, 40～80 parts of Rhizoma Pinelliae, 20～40 parts on Flos Carthami, 40～80 parts of Radix Angelicae Pubescentiss, 40～80 parts of Arisaema Cum Bile, 40～80 parts of Fructus Chaenomeliss, 40～80 parts of Fructus Gardeniaes, 30～60 parts of Pollen Typhaes, 30～60 parts of Lignum Sappans, 40～80 parts of Fructus Liquidambaris and Rhizoma Et Radix Notopterygii.
2. according to the external use muscle relaxing preparation of the described treatment traumatic injury of claim 1, rheumatic arthralgia, it is characterized in that: it is to make with Radix Aconiti Kusnezoffii 60g, Radix Paeoniae Rubra 30g, Camphora 60g, Pericarpium Zanthoxyli 60g, Radix Et Rhizoma Rhei 60g, Radix Aconiti 60g, Rhizoma Pinelliae 60g, Flos Carthami 30g, Radix Angelicae Pubescentis 60g, Arisaema Cum Bile 60g, Fructus Chaenomelis 60g, Fructus Gardeniae 60g, Pollen Typhae 45g, Lignum Sappan 45g, Fructus Liquidambaris 60g and Rhizoma Et Radix Notopterygii 60g.
3. treat traumatic injury as claimed in claim 1 or 2, the preparation method of the external use muscle relaxing preparation of rheumatic arthralgia, it is characterized in that: take by weighing Radix Aconiti Kusnezoffii, Radix Paeoniae Rubra, Pericarpium Zanthoxyli, Radix Et Rhizoma Rhei, Radix Aconiti, Rhizoma Pinelliae, Flos Carthami, Radix Angelicae Pubescentis, Arisaema Cum Bile, Fructus Chaenomelis, Fructus Gardeniae, Pollen Typhae, Lignum Sappan, Fructus Liquidambaris and Rhizoma Et Radix Notopterygii be totally ten five tastes, be ground into coarse powder, according to the percolation under Chinese Pharmacopoeia version appendix IO fluid extract in 2005 and the extractum item, make solvent with 50～70% ethanol, flood after 24～60 hours, with the speed of per minute 1～10ml percolation slowly, the collection liquid of filtering, after the stirring and dissolving that camphorates, filter, promptly get tincture of the present invention or fluid extract or extractum.
4. according to the described treatment traumatic injury of claim 3, the preparation method of the external use muscle relaxing preparation of rheumatic arthralgia, it is characterized in that: take by weighing Radix Aconiti Kusnezoffii, Radix Paeoniae Rubra, Pericarpium Zanthoxyli, Radix Et Rhizoma Rhei, Radix Aconiti, Rhizoma Pinelliae, Flos Carthami, Radix Angelicae Pubescentis, Arisaema Cum Bile, Fructus Chaenomelis, Fructus Gardeniae, Pollen Typhae, Lignum Sappan, Fructus Liquidambaris and Rhizoma Et Radix Notopterygii be totally ten five tastes, be ground into coarse powder, according to the percolation under Chinese Pharmacopoeia version appendix IO fluid extract in 2005 and the extractum item, make solvent with 60% ethanol, flood after 48 hours, with the speed of per minute 1～3ml percolation slowly, the collection liquid of filtering, after the stirring and dissolving that camphorates, filter, promptly get tincture of the present invention or fluid extract or extractum.
5. treat the preparation method of the external use muscle relaxing preparation of traumatic injury, rheumatic arthralgia as claimed in claim 1 or 2, it is characterized in that: take by weighing Radix Aconiti Kusnezoffii, Radix Paeoniae Rubra, Camphora, Pericarpium Zanthoxyli, Radix Et Rhizoma Rhei, Radix Aconiti, Rhizoma Pinelliae, Flos Carthami, Radix Angelicae Pubescentis, Arisaema Cum Bile, Fructus Chaenomelis, Fructus Gardeniae, Pollen Typhae, Lignum Sappan, Fructus Liquidambaris and Rhizoma Et Radix Notopterygii totally ten Six-elements, pulverize, mix, promptly get active ingredient of the present invention, the active ingredient that obtains is added required adjuvant, make required preparation according to a conventional method.
6. according to the preparation method of the external use muscle relaxing preparation of the described treatment traumatic injury of claim 5, rheumatic arthralgia, it is characterized in that: take by weighing Radix Aconiti Kusnezoffii, Radix Paeoniae Rubra, Camphora, Pericarpium Zanthoxyli, Radix Et Rhizoma Rhei, Radix Aconiti, Rhizoma Pinelliae, Flos Carthami, Radix Angelicae Pubescentis, Arisaema Cum Bile, Fructus Chaenomelis, Fructus Gardeniae, Pollen Typhae, Lignum Sappan, Fructus Liquidambaris and Rhizoma Et Radix Notopterygii totally ten Six-elements, be crushed to 100～300 orders, mixing, add one or more mixing in an amount of vaseline, paraffin, Polyethylene Glycol, Cera Flava, the lanoline, promptly get unguentum of the present invention.
7. according to the preparation method of the external use muscle relaxing preparation of the described treatment traumatic injury of claim 5, rheumatic arthralgia, it is characterized in that: take by weighing Radix Aconiti Kusnezoffii, Radix Paeoniae Rubra, Camphora, Pericarpium Zanthoxyli, Radix Et Rhizoma Rhei, Radix Aconiti, Rhizoma Pinelliae, Flos Carthami, Radix Angelicae Pubescentis, Arisaema Cum Bile, Fructus Chaenomelis, Fructus Gardeniae, Pollen Typhae, Lignum Sappan, Fructus Liquidambaris and Rhizoma Et Radix Notopterygii totally ten Six-elements, pulverize the back and cross 80～100 mesh sieves, add an amount of glycerin gelatine then or the PEG class is made substrate, promptly get paste of the present invention.
8. according to the preparation method of the external use muscle relaxing preparation of the described treatment traumatic injury of claim 5, rheumatic arthralgia, it is characterized in that: take by weighing Radix Aconiti Kusnezoffii, Radix Paeoniae Rubra, Camphora, Pericarpium Zanthoxyli, Radix Et Rhizoma Rhei, Radix Aconiti, Rhizoma Pinelliae, Flos Carthami, Radix Angelicae Pubescentis, Arisaema Cum Bile, Fructus Chaenomelis, Fructus Gardeniae, Pollen Typhae, Lignum Sappan, Fructus Liquidambaris and Rhizoma Et Radix Notopterygii totally ten Six-elements, pulverize, use 60% alcohol dipping, stir once every day, filter, filtrate adds 60% ethanol to 10000ml, promptly gets liniment of the present invention.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2006102007373A CN100438896C (en) | 2006-07-25 | 2006-07-25 | External use muscle relaxing preparation for treating traumatic injury and rheumatism stagnation pain and its preparing method |
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| CNB2006102007373A CN100438896C (en) | 2006-07-25 | 2006-07-25 | External use muscle relaxing preparation for treating traumatic injury and rheumatism stagnation pain and its preparing method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101024003B (en) * | 2007-03-26 | 2010-05-19 | 河南仲景药业股份有限公司 | Medicine for treating injury and preparing method |
| CN105998497A (en) * | 2016-07-11 | 2016-10-12 | 陈堃 | Traditional-Chinese-medicine tincture formula for treating bone arthralgia and preparing method |
| CN107362252A (en) * | 2017-07-20 | 2017-11-21 | 闫鹏生 | A kind of medicinal liquor for treating traumatic injury |
| CN112587638A (en) * | 2020-12-29 | 2021-04-02 | 四川标创生物科技有限公司 | Rheumatism plaster, plaster patch and preparation method of plaster |
-
2006
- 2006-07-25 CN CNB2006102007373A patent/CN100438896C/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101024003B (en) * | 2007-03-26 | 2010-05-19 | 河南仲景药业股份有限公司 | Medicine for treating injury and preparing method |
| CN105998497A (en) * | 2016-07-11 | 2016-10-12 | 陈堃 | Traditional-Chinese-medicine tincture formula for treating bone arthralgia and preparing method |
| CN107362252A (en) * | 2017-07-20 | 2017-11-21 | 闫鹏生 | A kind of medicinal liquor for treating traumatic injury |
| CN112587638A (en) * | 2020-12-29 | 2021-04-02 | 四川标创生物科技有限公司 | Rheumatism plaster, plaster patch and preparation method of plaster |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100438896C (en) | 2008-12-03 |
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