CN1135108C - Medicine for treating traumatic injury and relieving pain - Google Patents
Medicine for treating traumatic injury and relieving pain Download PDFInfo
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Abstract
The present invention discloses medicine for alleviating pain of traumatic injury, which is prepared from chlorophytum, thin evodia, garden balsam stem, notoginseng, dragon blood, safflower, peach seed, olibanum, myrrh, angelica, hemlock parsley, nux vomica, kusnezoff monkshood root, manchurian wildginger, doubleteeth pubesscent angelica root, cassia twig, cyathula root, borneol and menthol according to certain weight ratios, wherein chlorophytum is used as main medicine. The clinical application of the present invention of 350 patients shows that a total effective rate is 96.86%, the present invention has good effects of activating blood circulation, dissipating blood stasis, dispersing swelling, relieving pain, relieving rigidity of muscle, activating collaterals and activating joints, and is ideal medicine for treating injury of joints.
Description
The present invention relates to the medicine of a kind of external curing joint and soft tissue injury.
In recent years, along with the opening of society, the increase of movement of population amount and people like that to motion the incidence rate of traumatic injury, bruise and athletic injury obviously improves.Though this class disease can not threat to life, bring great influence for people's work and life.Joint injury belongs to the traditional Chinese medical science " injury of tendon and muscle " category.Motherland's medical science is thought, the swelling that muscle and tendon injury causes, pain are owing to after human body is subjected to external force damage, involve the QI and blood passages through which vital energy circulates, due to QI-blood circulation is smooth.So-called: " the tumbling down sprain and contusion, the soldier so experiences, QI and blood is all also sick and wounded "." impairment of QI resulting in pain, injury of configuration resulting in swelling ", the breakage of muscle arteries and veins, outside the blood oozing from the body openings or subcuta neous tissue arteries and veins, coagulation of QI-blood, it is not smooth to circulate, so see and swell and ache.Bone is to do, tendon functioning as tenacity, after the injury of tendon and muscle, firm is not firm, so see limitation of activity "." limbs decrease in outside, then QI and blood is hindered in interior.Battalion defends to some extent and does not pass through, internal organs by discord ".So the pathomechanism of the injury of tendon and muscle is a qi stagnation hemagglutination, its Therapeutic Principle is blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain.Modern medicine study shows that osteoarticular injury is a kind of damage that causes soft tissues such as joint capsule external ligament, muscle, tendon under the violence effect.Swelling is that intravascular fluid is seeped into due to the interstice outward owing to capillary rupture, permeability hemorrhage and blood vessel wall increase; And pain is because the local peripheral nerve of traumatic hematoma or inflammatory reaction material incentive causes; Wounded tissue lacerated wound in various degree causes the affected part limitation of activity.There is following problem in this class disease treatment both at home and abroad at present:
(1), existing Chinese patent medicine such as curative effects such as bone-setting liquor, the grieved liniment that disappears are not remarkable, and toxicity and zest are big, use inconvenient;
(2) the Western medicine class at present normal use as Vitalin Emulgel etc., untoward reaction is more, mainly contains skin pruritus, rubescent, twinge, rapid breakout, a few patients still has photosensitivity reaction.And can not use diclofenac, aspirin and other NSAID (non-steroidal anti-inflammatory drug) allergy sufferers.
For addressing the above problem, the object of the present invention is to provide a kind ofly to have analgesia, antiinflammatory, invigorate blood circulation and the detumescence effect, be applicable to the medicine of treatment joint and soft tissue injury, characteristics such as that this medicament has is evident in efficacy, toxicity and zest thereof are little, easy to use.
For achieving the above object, the present invention adopts following scheme:
A kind of medicine for the treatment of joint and soft tissue injury is a principal agent with the Herba Chlorophyti Laxi, and is formulated by the spice of following weight proportion:
Herba Chlorophyti Laxi 15～20 Foliumet Ramulus Evodiae 10～15 Herba speranskiae tuberculataes 8～10
Radix Notoginseng 3～5 Sanguis Draxonis 1～3 Flos Carthami 5～10
Semen Persicae 5～10 Olibanums 3～5 Myrrhas 3～5
Radix Angelicae Sinensis 5～10 Rhizoma Chuanxiongs 5～10 Semen Strychni 5～10
Radix Aconiti Kusnezoffii 3～5 Herba Asaris 3～5 Radix Angelicae Pubescentiss 5～10
Ramulus Cinnamomi 5～10 Radix Cyathulaes 5～10 Borneolum Syntheticums 1～2
Mentholum 1～2.
The weight proportion optimum range of above-mentioned spice is:
Herba Chlorophyti Laxi 15 Foliumet Ramulus Evodiae 12 Herba speranskiae tuberculataes 9
Radix Notoginseng 3 Sanguis Draxonis 1.8 Flos Carthamis 6
Semen Persicae 6 Olibanums 3 Myrrhas 3
Radix Angelicae Sinensis 6 Rhizoma Chuanxiongs 6 Semen Strychni 4.5
Radix Aconiti Kusnezoffii 3 Herba Asaris 3 Radix Angelicae Pubescentiss 6
6 river noon of Ramulus Cinnamomi knee joint 6 Borneolum Syntheticums 1.2
Mentholum 1.2.
Herba Chlorophyti Laxi in the above-mentioned prescription has significant analgesia, antiinflammatory and detumescence effect; Foliumet Ramulus Evodiae has the merit of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, anti-inflammatory analgetic; Radix Notoginseng, Sanguis Draxonis, Flos Carthami, Semen Persicae, Olibanum, Myrrha, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain effect are arranged; Herba speranskiae tuberculatae has relaxing muscles and tendons and activating QI and blood in the collateral, the continuous harm usefulness of synthetism, and Semen Strychni, Radix Aconiti Kusnezoffii, Borneolum Syntheticum etc. have dispelling wind and removing obstruction in the collateral, anti-inflammatory analgesic action.All medicines share, and play the effect of blood circulation promoting and blood stasis dispelling, antiinflammatory, heat-clearing and toxic substances removing, reducing swelling and alleviating pain and relaxing muscles and tendons and activating QI and blood in the collateral altogether.Through 350 routine clinical practice total effective rates is 96.86%, shows that the medicine of treatment of the present invention joint and soft tissue injury has the effect of stronger blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, relaxing muscles and tendons and activating QI and blood in the collateral, easing joint movement, is the ideal medicament of treatment joint injury.The characteristics division is as follows:
The The pharmacological results of partly describing at embodiment confirms that the medicine of treatment joint and soft tissue injury reaches 65.6%～93.8% to the analgesia rate that 0.8% glacial acetic acid causes the pain mice, pain threshold to the mice hot plate method can obviously improve, suppression ratio to the scorching mice ear of 100% caused by dimethylbenzene xylene reaches 34.6%～59.2%, 100% Ovum Gallus domesticus album is caused scorching rat paw edema also the obvious suppression effect, shows that the medicine of treatment of the present invention joint and soft tissue injury has significant Repercusion analgesia effect.
And clinical observation proves that also the hydrotherapy that bonesets of the medicine of treatment of the present invention joint and soft tissue injury imitates significantly (seeing the embodiment part for details): observe treatment joint and soft tissue injury patient 350 examples at Zhongshan Traditional Chinese Medical Hospital's orthopedics department, and observe 110 examples in contrast with bone-setting liquor, the result treats the medication therapy groups of joint and soft tissue injury and cures 175 examples, produce effects 117 examples, effective 47 examples, invalid 11 examples, total effective rate reaches 96.86%; And the bone-setting liquor matched group is cured 15 examples, produce effects 26 examples, effective 44 examples, invalid 25 examples, total effective rate 77.27%.Two groups of curative effects are learned processing by statistics, difference highly significant (P＜0.01).
Side effect is little: show through animal (rabbit) control experiment, the medicine of treatment of the present invention joint and soft tissue injury is through the skin administration, do not see obvious toxic and side effects is arranged, it is 2 grades that dermoreaction stimulates progression, be utmost point minimal irritation, it is 4 grades that the bone-setting liquor dermoreaction stimulates progression, for slightly～moderate stimulates.The clinical drug of treatment joint and soft tissue injury is observed 350 examples, has 5 examples the mild skin reaction to occur, and rate of side effects is 1.43%, and the result shows that the drug side effect of treatment joint and soft tissue injury is less.
The present invention is further described below in conjunction with embodiment:
Take by weighing the spice that is ground into coarse powder by following proportioning:
Herba Chlorophyti Laxi 2.5kg Foliumet Ramulus Evodiae 2kg Herba speranskiae tuberculatae 1.5kg
Radix Notoginseng 0.5kg Sanguis Draxonis 0.3kg Flos Carthami 1kg
Semen Persicae 1kg Olibanum 0.5kg Myrrha 0.5kg
Radix Angelicae Sinensis 1kg Rhizoma Chuanxiong 1kg Semen Strychni 0.8kg
Radix Aconiti Kusnezoffii 0.5kg Herba Asari 0.5kg Radix Angelicae Pubescentis 1kg
Ramulus Cinnamomi 1kg Radix Cyathulae 1kg Borneolum Syntheticum 0.2kg
Mentholum 0.2kg
Except that Borneolum Syntheticum, Mentholum, all the other Chinese medicines add 60% soak with ethanol with above-mentioned raw material of Chinese medicine, totally 3 times, each more than 7 days, after the leaching leachate, add 60% ethanol to 10, ten thousand ml again, make the drug level of the medicine of treatment joint and soft tissue injury reach 17% (g/ml), stir evenly, leave standstill, filter, divide in the 50ml air-pot of packing into and make spray, certainly also can be made into other dosage forms, as exterior-applied formulations such as tincture, solution and ointments.
Traumatic injury analgesic agent external of the present invention, the affected part is wiped in spray, and is each an amount of every day three times, is massaged into heating.
Be further described below in conjunction with analgesia, the antiinflammatory action of pharmacological evaluation the medicine of treatment of the present invention joint and soft tissue injury:
One. experiment material
(1) animal and grouping
1, animal: regular grade NIH mice, body weight 18～22 grams, male 59 female 83; Regular grade SD rat, body weight 150～180 grams, male 60; 8 of rabbit (big mice is available from Guangdong Medical Lab Animal Center, and rabbit is provided by Zhongshan Traditional Chinese Medical Hospital's Animal House).
2, grouping: the medicine low dose group of (1) treatment joint and soft tissue injury:
The medicine of 100% treatment joint and soft tissue injury;
(2) the medicine high dose group of treatment joint and soft tissue injury:
The medicine of 200% treatment joint and soft tissue injury;
(3) positive controls: bone-setting liquor is coated with outward;
(4) blank group: normal saline is coated with outward.
(2) medicine of treatment joint of the present invention and soft tissue injury is made by the applicant, and bone-setting liquor is available from intelligence medicine company limited in the Zhongshan city, and Yulin Pharmaceutic Factory, Gangxi Autonomous Region produces, lot number 99091804.
(3) reagent and instrument
Glacial acetic acid, dimethylbenzene, ether (analytical pure);
Syringe, water bath, metal dish, stopwatch, micropipet, electronic balance, card punch, volumetric measurement device, hair clipper, shears, sterilized filter paper, antiseptic gauze, nonirritant adhesive plaster.
Two, method and result
(1) analgesic activity
1, the inhibitory action of mouse writhing reaction
Get 56 of NIH mices, body weight 18～22g, male and female half and half are divided into four groups at random.Coating medicine-feeding, 1h after the administration, every Mus lumbar injection 0.8% glacial acetic acid 0.1ml/10g.Interior each Mus of 30min was turned round the body number of times after record gave algogen, the results are shown in Table 1.
The medicament spraying agent of table 1 treatment joint and soft tissue injury is to mouse writhing
The influence of reaction
| Group | Number of animals | 30min turns round body number of times X ± SD | Analgesia rate (%) |
| The normal saline group | 14 | 64±27 | |
| The medicine group of 100% treatment joint and soft tissue injury | 14 | 22±26 *** | 65.6 |
| The medicine group of 200% treatment joint and soft tissue injury | 14 | 4±7 *** | 93.8 |
| The bone-setting liquor group | 14 | 15±22 *** | 76.6 |
Compare with matched group
* *P＜0.001
The result shows: the mouse writhing that the medicine of the medicine of 100% treatment joint and soft tissue injury, 200% treatment joint and soft tissue injury and bone-setting liquor all can obviously suppress to be caused by glacial acetic acid reacts, and the drug effect of 200% treatment joint and soft tissue injury is better than bone-setting liquor.
(2) to the influence of the mice hot plate threshold of pain:
Get 31 of NIH mices, female, be divided into four groups at random.Water bath with thermostatic control is adjusted to 55 ± 1 ℃, the metal dish bottom contact water surface, mice is write down from dropping into hot plate to the pain threshold of the time of metapedes as this Mus occurring licking as thermostimulation with stopwatch in the heating back.Every preceding pain threshold of measuring every mice earlier of mice administration is surveyed secondary altogether, is no more than 30s person for qualified with meansigma methods.Scurry jumping, bradykinesia and pain threshold need not with the epigenesist rejecting 10～30 seconds scopes.Outside the extremity foot sole of the foot, be coated with normal saline respectively by group, bone-setting liquor, the medicine of treatment joint and soft tissue injury.Half an hour after the record administration, 1 hour, 1.5 hours, 2 hours, 3 hours, the pain threshold of 4 hours each Mus (surpass 60s and press 60s calculating) calculated threshold of pain increase difference and improves percentage rate with Ge Shi pain threshold mutually, the results are shown in Table 2.
The medicament spraying agent of table 2 treatment joint and soft tissue injury is to mice
The influence of the hot plate threshold of pain
| Group | Number of animals | The threshold of pain increases difference X ± SD (second) and improves percentage rate (%) | |||||
| Half an hour | 1 hour | 1.5 hour | 2 hours | 3 hours | 4 hours | ||
| The normal saline group | 8 | 0.1±4.8 | -2.8±5.2 | -3.6±5.7 | -2.5±4.0 | -1.0±4.6 | 3.1±3.1 |
| 0 | -23.1 | -23.1 | -15.4 | -7.7 | 23.1 | ||
| The medicinal liquid group of 100% treatment joint and soft tissue injury | 7 | 25.3 ±20.9 ** | 15.9±20.7 * | 16.1±20.9 * | 8.6±17.9 | 13.7±22.1 | 3.4±15.1 |
| 156.3 | 100 | 100 | 56.3 | 87.5 | 18.8 | ||
| The medicinal liquid group of 200% treatment joint and soft tissue injury | 8 | 41.1±9.3 *** | 34.3±17.5 *** | 21.2±23.2 * | 8.3±14.0 | 11.3±13.5 | 9.0±12.4 |
| 256.3 | 212.5 | 131.3 | 50 | 68.8 | 56.3 | ||
| The bone-setting liquor group | 8 | 37.0±13.2 *** | 30.6±21.2 *** | 30.1±22.8 ** | 20.6±24.0 * | 21.0±25.5 * | 0.6±5.4 |
| 194.7 | 157.9 | 152.6 | 105.3 | 110.5 | 0 | ||
Compare with matched group
*P＜0.05
*P＜0.01
* *P＜0.001
The result shows: the medicine and the bone-setting liquor of the medicine of 100% treatment joint and soft tissue injury, 200% treatment joint and soft tissue injury all can obviously improve the mice pain threshold.
(2) antiinflammatory action
1, the inhibitory action that mice ear is formed is got 55 of 18～22g male mices, be divided into four groups at random, etherization, according to group each medicinal liquid is applied to mouse right ear tow sides (not adding friction), accurately draw the scorching liquid 100ul of 100% caused by dimethylbenzene xylene with micropipet after 1 hour and be applied to the auris dextra tow sides, left ear is made blank.After causing scorching 1h, the disconnected neck of mice is put to death, cut two ears along the auricle baseline, lay round auricle at same position respectively with 9mm diameter card punch, with one thousandth electronic balance (Shanghai balance equipment factory, model: TA1203) weigh, the auris dextra sheet weight of every Mus deducts left auricle weight and is the swelling degree, calculates inhibitory rate of intumesce.The results are shown in Table 3.
The influence that the medicament spraying agent of table 3 treatment joint and soft tissue injury forms mice ear
| Group | Number of animals | Auris dextra heavy (mg) | Left side ear heavy (mg) | The swelling degree | Inhibitory rate of intumesce |
| X±SD | X±SD | X±SD | 1％ | ||
| The normal saline group | 14 | 35.2±8.9 | 16.1±1.3 | 19.1±8.7 | 0 |
| The medicinal liquid group of 100% treatment joint and soft tissue injury | 14 | 27.9±7.7 | 15.4±1.5 | 12.5 ±7.9 * | 34.6 |
| The medicinal liquid group of 200% treatment joint and soft tissue injury | 13 | 24.3±5.6 | 16.6±1.7 | 7.8±5.4 *** | 59.2 |
| The bone-setting liquor group | 14 | 27.5±5.2 | 15.8±4.7 | 10.2±4.2 *** | 46.6 |
Compare with matched group
*P＜0.05
* *P＜0.001
The result shows: the medicine of the medicine of 100% treatment joint and soft tissue injury, 200% treatment joint and soft tissue injury and bone-setting liquor all can obviously can suppress the mice ear that caused by dimethylbenzene, the drug effect highly significant of 200% treatment joint and soft tissue injury wherein, suppression ratio is than the height of bone-setting liquor.
2, the inhibitory action that the swelling of rat toes is formed
Select 60 of SD rats for use, body weight 150～180g, male, be divided into four groups at random.Coating medicine-feeding after 1 hour, will 100% Ovum Gallus domesticus album (every rat is used 0.1ml) injects under the right back sufficient plantar aponeurosis of rat and causes inflammation, every 1 hour with capillary tube measurement by magnification measurement device, write down 1,2,3,4,5 hour foot swelling degree, the results are shown in Table 4.
The medicament spraying agent of table 4 treatment joint and soft tissue injury is to the influence of rat toes Ovum Gallus domesticus album inflammation
| Group | Number of animals | Cause the toes swelling degree (ml) of scorching back different time (h) | ||||
| 1 | 2 | 3 | 4 | 5 | ||
| The normal saline group | 15 | 0.91±0.15 | 0.87±0.18 | 0.79±0.12 | 0.73±0.13 | 0.59±0.18 |
| The medicinal liquid group of 100% treatment joint and soft tissue injury | 15 | 0.69±0.14 *** | 0.71±0.13 ** | 0.63±0.14 ** | 0.52±0.14 ** | 0.47±0.13 |
| The medicinal liquid group of 200% treatment joint and soft tissue injury | 15 | 0.67 ±0.13 *** | 0.58±0.11 *** | 0.57±0.17 *** | 0.45±0.12 *** | 0.34±0.14 *** |
| The bone-setting liquor group | 15 | 0.64±0.14 *** | 0.65±0.16 ** | 0.56±0.17 *** | 0.58±0.20 * | 0.49±0.20 |
Compare with matched group
*P＜0.05
*P＜0.01
* *P＜0.001
The result shows: the medicine of the medicine of 100% treatment joint and soft tissue injury, 200% treatment joint and soft tissue injury and bone-setting liquor all can obviously suppress the rat toes swelling that caused by Ovum Gallus domesticus album.Wherein the drug treating time of 200% treatment joint and soft tissue injury is long, the effect highly significant.Three, to the irritant experiment of skin
Get healthy do not have hinder, 8 of the white rabbit of body weight 2.0～2.5Kg, be divided into 2 groups, 4 every group.The I group is used bone-setting liquor with the medicine of treatment joint and soft tissue injury, II group, and III represents blank.In preceding 24 hours of administration with tame rabbit back both sides unhairing.The unhairing area be about body surface area 10% (the every side of rabbit is about 70cm
2).
Liquid is tried the thing dropping, and (be generally 1～2ml) on sterilized filter paper sheet (two layers), be affixed on rabbit one side back, cover with one deck oilpaper and two-layer gauze, the sealing of reuse nonirritant adhesive plaster is fixed or dressing, makes test sample can contact skin better in right amount.Opposite side is made blank.Behind 4～6h, removed behind the residual test sample 30～60 minutes, checked test sample to rabbit skin irritant reaction in 24,48 hours, according to the form below is divided the order of reaction:
| Dermoreaction stimulates progression | ||
| The order of reaction | Irritant reaction | |
| 0 | Erythema and eschar | No erythema III |
| 1 | Slight erythema (reluctantly as seen) I | |
| 2 | Middle rank erythema II | |
| 3 | The severe erythema | |
| 4 | Severe erythema to slight eschar forms | |
| 0 | Edema | No edema III |
| 1 | Slight edema (reluctantly as seen) I | |
| 2 | Slight edema (profile raised panel is clear) II | |
| 3 | Intermediate edema (swell about 1mm) | |
| 4 | Serious edema (protuberance surpasses 1mm, and exceeds drug of topical application area) | |
The result shows: by last table order of reaction sum, illustrate that the dermoreaction stimulation progression of the medicine of treatment joint and soft tissue injury is 2 grades, erythema and eschar reluctantly as seen, edema is reluctantly as seen; It is 4 grades that the dermoreaction of bone-setting liquor stimulates progression, and intermediate erythema is arranged, slight edema, and profile raised panel is clear, and the zest that shows the medicine for the treatment of joint and soft tissue injury is less than bone-setting liquor.
Experimental result shows: the medicament spraying agent of treatment joint and soft tissue injury has good detumescence, analgesic effect.This test adopts the medicine of treatment joint and soft tissue injury to confirm that in multiple inflammation, pain model the medicine of treatment joint and soft tissue injury has obvious inhibition by the rat paw edema due to the Ovum Gallus domesticus album; Inhibition is by formaldehyde induced mice ear swelling; Obviously improve the pain threshold of mice; Significantly suppress the writhing response that mice is caused by glacial acetic acid.Skin irritation test shows: the medicament spraying agent of treatment joint and soft tissue injury is little to skin irritation.
Below be clinical report about the Drug therapy joint injury of treatment joint and soft tissue injury:
Joint injury is the orthopedics department commonly encountered diseases, especially with joint injuries such as extremity ankle, wrist, elbow, shoulder, knee joint, hips for seeing more.The author is through the treatment joint of for many years clinical practice development and the medicine of soft tissue injury, through 350 routine clinical practices, and compares with bone-setting liquor and to observe 110 examples relatively, and is respond well, now is reported as follows.
1 clinical data
1.1 physical data is selected the closed damage in joints such as extremity ankle, wrist, elbow, shoulder, knee joint, hip, the local pain that causes, swelling, ecchymosis, joint function disturbance etc. in the injured 3 days time, do not comprise that cases such as fracture, dislocation, nerve injury are the object of observation.Observe 460 examples altogether, and be divided into 2 groups at random.Medicine group (treatment group) 350 examples of treatment joint and soft tissue injury, male 183 examples, women 167 examples, 12～67 years old age.Sprained ankle 130 examples (37.14%) wherein, carpal joint damages 76 examples (21.71%), and elbow joint damages 62 examples (17.71%), and shoulder joint is damaged 37 examples (10.57%), knee joint injury 28 examples (8.00%), hip joint damages 17 examples (4.86%).Bone-setting liquor group (matched group) 110 examples, male 62 examples, women 48 examples, 13～65 years old age.Sprained ankle 39 examples (35.45%) wherein, carpal joint damages 25 examples (22.73%), and elbow joint damages 21 examples (19.1%), and shoulder joint is damaged 12 examples (10.10%), knee joint injury 10 examples (9.10%), hip joint damages 3 examples (2.73%).The sex of two groups of cases, age, the state of an illness and damage location are consistent basically.
1.2 state of an illness index scoring pain: slight (1 minute): when static the injury swell or pain lighter, increase the weight of when movable.Moderate (2 minutes): injury distending pain or pain are more obvious when static.Severe (3 minutes): injury pain seriously unbearably when static.Tenderness: tenderness scope＜2cm
2The person is slight (1 minute), 2～4cm
2The person is moderate (2 minutes),＞4cm
2The person is severe (3 minutes).Swelling: slightly swell the injury, and path length＜1cm person is slight (1 minute) than strong side week, and 1～2cm person is moderate (2 minutes), and＞2cm person is severe (3 minutes).Ecchymosis: ecchymosis＜3cm
2The person is slight (1 minute), 3～6cm
2The person is moderate (2 minutes),＞6cm
2The person is severe (3 minutes).The movable function obstacle: joint motion is limited＜5 ° be slight (1 minute), joint motion is limited in 5 °～10 ° and is moderate (2 minutes), joint motion is limited＞10 ° of persons are severe (3 minutes).State of an illness index appraisal result: slight (4 minutes) 39 examples (11.14%) of treatment group, moderate (8 minutes) 125 examples (35.71%), severe (12 minutes) 186 examples (53.14%), matched group is respectively 24 examples (21.82%), 49 examples (44.54%), 37 examples (33.64%).
2 Therapeutic Method
2.1 prescription is formed with more than 20 kind of Chinese herbal medicine such as preparation Herba Chlorophyti Laxi, Foliumet Ramulus Evodiae, Herba speranskiae tuberculatae, Radix Notoginseng, Sanguis Draxonis, Flos Carthami, Semen Persicae, Olibanum, Myrrha, Semen Strychni, Radix Aconiti Kusnezoffii, Borneolum Syntheticums, makes tincture by the Drug Manufacturing Room of the court, the 50ml/ bottle.Bone-setting liquor is the street drug that Yulin Pharmaceutic Factory, Gangxi Autonomous Region produces.
2.2 usage adopts medicine, the bone-setting liquor medicinal liquid of treatment joint and soft tissue injury to embrocate in the affected part with taboo respectively by treatment group, matched group, with have gentle hands by to heating, each 5～10ml or with the soak of yarn piece, every day 3 times, be 10 days the course of treatment.This product is forbidden inlet, eye, nose and skin injury place, ethanol allergy sufferers and contraindication in pregnancy.
3 therapeutic outcomes
Criterion of therapeutical effect is divided into healing:conscious pain disappearance, and ecchymosis dissipates, and tenderness, swelling disappear, and the function of joint activity recovers normal or state of an illness index was marked 0～1 fen; Produce effects:conscious pain disappears or slight pressure pain is arranged, or sense of discomfort is arranged after the fatigue, and ecchymosis dissipates, and swelling disappears, and the function of joint activity recovers normal substantially or state of an illness index was marked 2～3 fens; Effectively:pain, tenderness obviously alleviate, and ecchymosis, swelling are disappeared substantially, and the function of joint activity obviously improves or state of an illness index was marked 4～5 fens; Invalid:symptom; Sign were marked＞6 fens not as good as responder or state of an illness index.The result:treatment is organized and is cured, 175 examples in, 350 examples; Accounts for 50.00%; And produce effects 117 examples account for 33.43%; And effective 47 examples account for 13.43%; And invalid 11 examples account for 3.14%; Total effective rate 96.86%.Cure 15 examples in matched group 110 examples; Account for 13.64%; Produce effects 26 examples account for 23.63%; And effective 44 examples account for 40.00%; And invalid 25 examples account for 22.73%; total effective rate 77.27％.Two groups of curative effects are learned processing by statistics, difference highly significant P＜0.01.1.2.1 （ ％ ） （ ％ ） （ ％ ） （ ％ ） （ ％ ） 39 23 （ 58.97 ） 11 （ 28.20 ） 4 （ 10.25 ） 1 （ 2.56 ） （ 97.44 ） 125 63 （ 50.04 ） 41 （ 32.80 ） 17 （ 13.60 ） 4 （ 3.20 ） （ 96.80 ） 186 89 （ 47.85 ） 65 （ 34.95 ） 26 （ 13.98 ） 6 （ 3.20 ） （ 96.80 ） 350 175 （ 50.00 ） 117 （ 33.43 ） 47 （ 13.43 ） 11 （ 3.14 ） （ 96.86 ） 2 （ ％ ） （ ％ ） （ ％ ） （ ％ ） （ ％ ） 24 4 （ 16.66 ） 8 （ 33.33 ） 7 （ 29.17 ） 5 （ 20.08 ） （ 79.16 ） 49 7 （ 50.04 ） 11 （ 22.45 ） 20 （ 40.82 ） 11 （ 22.45 ） （ 77.54 ） 37 4 （ 14.28 ） 7 （ 18.92 ） 17 （ 45.95 ） 9 （ 24.32 ） （ 75.68 ） 110 15 （ 10.80 ） 26 （ 23.63 ） 44 （ 40.00 ） 25 （ 22.73 ） （ 77.27 ）。
Have 5 examples (1.43%) dermoreaction to occur in the medicine group 350 of treatment joint and soft tissue injury, wherein drug eruption appears in 3 examples, with slight pruritus.After the drug withdrawal 2～3 days, deflorescence.2 examples have burn feeling, disappear after the drug withdrawal.Bone-setting liquor group 110 examples have 4 examples (3.64%) dermoreaction to occur, 2 routine drug eruption wherein, and 2 examples have burn feeling, disappear after the drug withdrawal.
4, model case
Lee, man 32 years old, workman.Sprain the right side ankle joint when October 6 got out of a predicament or an embarrassing situation in 1998 accidentally, pain unbearably, prescription on individual diagnosis in back 2 hours is hindered in the walking of can not standing.Check: right side ankle swelling, obvious, strong side Zhou Jing＞3cm, ecchymosis scope＞3cm with the external malleolus place
2, right ankle joint moving obstacle.Tenderness scope＞5cm
2, obvious with right external malleolus, lower tibiofibula associating portion tenderness, bony crepitus is touched at the end.The X ray examination does not have fracture, dislocation is levied.Be diagnosed as right sprained ankle.Promptly give the outer scrape along of the medicine yarn piece soak of maneuver restoring and treating injured soft tissues, treatment joint and soft tissue injury, and keep strephexopodia to fix.Drenched the medicine 1 time of treatment joint and soft tissue injury every 4～5 hours, each 10～20ml.Further consultation in the 3rd day, swelling and ache obviously alleviates, ecchymosis scope＜3cm
2, tenderness scope＜4cm
2, the ankle joint back of the body is stretched 30 °, and the sole of the foot is bent 35 °.Continue medication 4 days, and advise the patient to strengthen ankle joint function and take exercise.Symptom and sign disappear substantially after 7 days, and the ankle joint back of the body is stretched 35 °, and the sole of the foot is bent 45 °, and walking is normal, resumes work.
Above-mentioned 350 routine clinical practice total effective rates are 96.86%, and the medicine of prompting treatment joint and soft tissue injury has the effect of stronger blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, relaxing muscles and tendons and activating QI and blood in the collateral, easing joint movement, are the ideal medicament of treatment joint injury.
Claims (2)
1, a kind of medicine for the treatment of joint and soft tissue injury is a principal agent with the Herba Chlorophyti Laxi, and is formulated by the spice of following weight proportion:
Herba Chlorophyti Laxi 15～20 Foliumet Ramulus Evodiae 10～15 Herba speranskiae tuberculataes 8～10
Radix Notoginseng 3～5 Sanguis Draxonis 1～3 Flos Carthami 5～10
Semen Persicae 5～10 Olibanums 3～5 Myrrhas 3～5
Radix Angelicae Sinensis 5～10 Rhizoma Chuanxiongs 5～10 Semen Strychni 5～10
Radix Aconiti Kusnezoffii 3～5 Herba Asaris 3～5 Radix Angelicae Pubescentiss 5～10
Ramulus Cinnamomi 5～10 Radix Cyathulaes 5～10 Borneolum Syntheticums 1～2
Mentholum 1～2.
2, a kind of medicine for the treatment of joint and soft tissue injury as claimed in claim 1 is characterized in that its spice by following weight proportion is formulated:
Herba Chlorophyti Laxi 15 Foliumet Ramulus Evodiae 12 Herba speranskiae tuberculataes 9
Radix Notoginseng 3 Sanguis Draxonis 1.8 Flos Carthamis 6
Semen Persicae 6 Olibanums 3 Myrrhas 3
Radix Angelicae Sinensis 6 Rhizoma Chuanxiongs 6 Semen Strychni 4.5
Radix Aconiti Kusnezoffii 3 Herba Asaris 3 Radix Angelicae Pubescentiss 6
Ramulus Cinnamomi 6 Radix Cyathulaes 6 Borneolum Syntheticums 1.2
Mentholum 1.2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB001308130A CN1135108C (en) | 2000-11-27 | 2000-11-27 | Medicine for treating traumatic injury and relieving pain |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB001308130A CN1135108C (en) | 2000-11-27 | 2000-11-27 | Medicine for treating traumatic injury and relieving pain |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1331981A CN1331981A (en) | 2002-01-23 |
| CN1135108C true CN1135108C (en) | 2004-01-21 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB001308130A Expired - Fee Related CN1135108C (en) | 2000-11-27 | 2000-11-27 | Medicine for treating traumatic injury and relieving pain |
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| CN104435323A (en) * | 2014-10-28 | 2015-03-25 | 王铁创 | Externally-applied traditional Chinese medicine composition for treating traumatic injury and administration mode thereof |
| CN104606313B (en) * | 2015-01-09 | 2018-01-12 | 金万德 | Treat bone and joint diseases and the Chinese medicinal ointment and preparation method of bone fracture |
| CN111905072A (en) * | 2020-07-17 | 2020-11-10 | 北京枢之道生物科技有限公司 | Clove antibacterial powder and preparation method thereof |
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