CN101919949A - Traditional Chinese medicine composition for treating rheumatic heart disease and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating rheumatic heart diseases and a preparation method thereof. The composition consists of the following ingredients by weight percent: 18%-28% of nux vomica, 6%-12% of Sanguis Draxonis, 18%-28% of nutgrass galingale rhizome, 3%-5% of frankincense, 3%-5% of myrrh, 6%-10% of orange peel and 8%-12% of Szechuan Lovage Rhizome, wherein the sum of the weight percents of the raw materials is 100%. The preparation method of the composite is as follows: according to different properties of each traditional Chinese medicine, removing impurities, drying, smashing, grinding into fine powder and preparing medicinal powder. The composition of the invention has remarkable treatment effects on treating rheumatic heart diseases, in particular on aspects of cleaning impurities in blood vessels, dredging blood vessels, repairing the function insufficiency of valvula bicuspidalis, can simultaneously treat emphysema, has low side effects and safe pharmacy, can be taken for a long time, and has simple preparation method and convenient administration.

Description

Chinese medicine composition of treatment rheumatic heart disease and preparation method thereof

Technical field

The invention belongs to the Chinese drug preparation technique field, relate to the Chinese medicine composition for the treatment of rheumatic heart disease, the invention still further relates to the preparation method of this Chinese medicine composition.

Background technology

Rheumatic heart disease (abbreviation rheumatic heart disease) belongs to common connective tissue disease, because rheumatic fever is shown effect repeatedly and is involved heart, cause damaged heart valve and form, show as have in Bicuspid valve, Tricuspid valve, the aortic valve one or several valvular stenosis and (or) incompetence, wherein, mitral incompetence mainly enlarges from pulmonary hypertension and low cardiac output.Its clinical manifestation mainly exists: but slight mitral incompetence person's non-evident sympton or slight sense of discomfort is only arranged; As active rheumatism, sx when infective endocarditis or rupture of chordae tendineae, atrial fibrillation takes place in 75% mitral incompetence patient, and atrial fibrillation can increase the pressure in left room, left ventricular volume is excessive to be to cause mitral incompetence, another major reason of patient's shortness of breath and palpitation; The common sympton of serious mitral incompetence has: activity endurance such as work dyspnea, tired, orthopnea significantly descend, and spitting of blood and thromboembolism are more rare; The enlargement of liver congestion can occur during right heart failure late period, tenderness is arranged, ankle edema, hydrothorax or ascites; Acute person can very fast generation acute left heart failure or pulmonary edema.

At present, for the Drug therapy of rheumatic heart disease, control Ventricular Rate and prevention blood vessel embolism are the emphasis of treatment, use beta-blocker control Ventricular Rate, can not tolerate if any taboo or patient, can use amiodarone, also can use Folium Digitalis Purpureae; Merge paroxysmal, persistence atrial fibrillation or previously have thromboembolism incident person to use anticoagulant therapy.Drug therapy also comprises diuretic, vasodilation, positive inotropic medicament, A.CEI/ Angiotensin (ARB) and B receptor blocking agent etc.

Repairing mitral valve function not in all directions, mainly adopt operative treatment: (1) valve repair art; (2) prosthetic valve replacement.

Though above Therapeutic Method is especially helpful to repairing Bicuspid valve to the treatment rheumatic heart disease, western medicine is expensive price not only, and the toxic and side effects height; Its side effect of operative treatment is big, cost is high, certain risk is arranged and postoperative complication is more, the post-operative recovery time is long, adaptability also limits to relatively, and show: the health to the people before the treatment has certain requirement or the like; In recent years, utilize the experimentation of modern Chinese medicine treatment rheumatic heart disease more and more to draw attention, but in the treatment rheumatic heart disease, it is average to improve mitral valve function aspect curative effect.

Summary of the invention

The object of the present invention is to provide the Chinese medicine composition of treatment rheumatic heart disease, it is many to have solved the untoward reaction that existing Western medicine long-term treatment brings, the big and operative treatment mitral valve function aspect cost height of side effect, the problem that has a big risk.Another object of the present invention provides the preparation method of above-mentioned Chinese medicine composition.

The technical solution adopted in the present invention is: a kind of Chinese medicine composition for the treatment of rheumatic heart disease, wherein making raw materials of effective components consists of by weight percentage: Semen Strychni 18%～28%, Sanguis Draxonis 6%～12%, Rhizoma Cyperi 18%～28%, Olibanum 3%～5%, Myrrha 3%～5%, Cortex Cinnamomi 8%～10%, Pericarpium Citri Reticulatae 6%～10%, Rhizoma Chuanxiong 8%～12%, the percentage by weight sum of each raw material is 100%.

Another technical scheme of the present invention is: a kind of preparation method for the treatment of the Chinese medicine composition of rheumatic heart disease, get Semen Strychni 18%～28% by weight percentage, Sanguis Draxonis 6%～12%, Rhizoma Cyperi 18%～28%, Olibanum 3%～5%, Myrrha 3%～5%, Cortex Cinnamomi 8%～10%, Pericarpium Citri Reticulatae 6%～10%, Rhizoma Chuanxiong 8%～12%, more than the percentage by weight sum of each raw material be 100%, above eight kinds of raw materials are carried out remove impurity, drying, pulverizing, mix homogeneously, make medicated powder with being ground into fine powder.

The third technical scheme of the present invention is: a kind of Chinese medicine composition for the treatment of rheumatic heart disease, this Chinese medicine composition are that leading of 1:5-8 organized thing and adminicle is formed by weight ratio, wherein,

Main group thing consists of by weight percentage: Semen Strychni 18%～28%, Sanguis Draxonis 6%～12%, Rhizoma Cyperi 18%～28%, Olibanum 3%～5%, Myrrha 3%～5%, Cortex Cinnamomi 8%～10%, Pericarpium Citri Reticulatae 6%～10%, Rhizoma Chuanxiong 8%～12%, the percentage by weight sum of main each raw material of group thing is 100%;

Adminicle consists of by weight percentage: Radix Angelicae Sinensis 6%～12%, Radix Polygoni Ciliinerve 6%～10%, Radix Rehmanniae Preparata 12%～18%, Radix Scutellariae 8%～10%, RADIX ACONITI LATERALIS PREPARATA (system) 4%～8%, Radix Saposhnikoviae 8%～12%, Ramulus Cinnamomi 8%～12%, Radix Glycyrrhizae 3%～7%, Herba Ephedrae 6%～12%, Fructus Aurantii 8%～12%, Radix Aconiti (system) 2%～5%, Fructus Corni 15%～20%, the percentage by weight sum of each raw material of adminicle is 100%.

The 4th kind of technical scheme of the present invention is: a kind of preparation method for the treatment of the Chinese medicine composition of rheumatic heart disease, and this method is carried out as follows:

Step 1, the main group of preparation thing

Get Semen Strychni 18%～28% by weight percentage respectively, Sanguis Draxonis 6%～12%, Rhizoma Cyperi 18%～28%, Olibanum 3%～5%, Myrrha 3%～5%, Cortex Cinnamomi 8%～10%, Pericarpium Citri Reticulatae 6%～10%, Rhizoma Chuanxiong 8%～12%, the percentage by weight sum of main each raw material of group thing is 100%, carry out remove impurity, drying, pulverizing, mix homogeneously, to make medicated powder standby with being ground into fine powder;

Step 2, the preparation adminicle

Get Radix Angelicae Sinensis 6%～12% by weight percentage respectively, Radix Polygoni Ciliinerve 6%～10%, Radix Rehmanniae Preparata 12%～18%, Radix Scutellariae 8%～10%, RADIX ACONITI LATERALIS PREPARATA (system) 4%～8%, Radix Saposhnikoviae 8%～12%, Ramulus Cinnamomi 8%～12%, Radix Glycyrrhizae 3%～7%, Herba Ephedrae 6%～12%, Fructus Aurantii 8%～12%, Radix Aconiti (system) 2%～5%, Fructus Corni 15%～20%, the percentage by weight sum of each raw material of adminicle is 100%, carry out remove impurity, drying, pulverizing, mix homogeneously, to make medicated powder standby with being ground into fine powder;

Step 3

Main group thing that step 1 and step 2 are prepared and adminicle medicated powder are with 1:5-8 ratio compatibility.

The invention has the beneficial effects as follows,

1. to select Chinese crude drug for use be raw material in the present invention, and each component meets the pharmaceutical control law regulation, utilizes the comprehensive function treatment rheumatic heart disease of the Chinese medicine of respectively distinguishing the flavor of, and gives full play to herbal toxic effect effect little, evident in efficacy, can thoroughly cure.

2. the present invention is repairing mitral valve function and double controlling has reasonable curative effect aspect the emphysema, can clear up the impurity in the blood vessel simultaneously, dredging vascellum.

3. taking convenience of the present invention can be directly oral.

The specific embodiment

The present invention is described in detail below in conjunction with the specific embodiment.

One, function and the function of each raw material in this medicine cures mainly

1. a kind of scheme of the present composition is: be made up of following raw material by weight percentage: Semen Strychni 18%～28%, Sanguis Draxonis 6%～12%, Rhizoma Cyperi 18%～28%, Olibanum 3%～5%, Myrrha 3%～5%, Cortex Cinnamomi 8%～10%, Pericarpium Citri Reticulatae 6%～10%, Rhizoma Chuanxiong 8%～12%, above each component percentage by weight sum is 100%.

The write out a prescription effect of each medicine of Chinese medicine composition of the present invention:

Semen Strychni: removing obstruction in the collateral to relieve pain, dispersing swelling and dissipating binds, be used for anemofrigid-damp arthralgia, be monarch drug.

Sanguis Draxonis: promoting blood circulation to remove blood stasis, analgesic therapy hemostasis, expelling pus and promoting granulation;

Rhizoma Cyperi: the resolving depression of regulating the flow of vital energy;

The shared merit that plays blood circulation promoting regulates qi for ministerial drug of Sanguis Draxonis and Rhizoma Cyperi.

Olibanum: be used for coagulation of QI-blood, trusted subordinate's pain;

Myrrha: be used for muscles and bones, all pains of trusted subordinate;

Cortex Cinnamomi: mend supporing yang, the dispersing cold for relieving pain of fire;

Olibanum, Myrrha, Cortex Cinnamomi help monarch, ministerial drug with assistant, and promoting blood circulation and stopping pain, the cold-damp of dispeling the wind numbness, benefit fire are with being adjuvant drug.

Pericarpium Citri Reticulatae: regulating qi-flowing for strengthening spleen, transfer in, dampness, reduce phlegm, with controlling the abdominal distention uncomfortable in chest in the turbid damp resistance, the cough and asthma of phlegm-damp heap soil or fertilizer over and around the roots lung;

Rhizoma Chuanxiong: blood-activating and qi-promoting, wind-expelling pain-stopping are used for rheumatic arthralgia;

Pericarpium Citri Reticulatae and Rhizoma Chuanxiong are messenger drug altogether, and drug effect is more strong and powerful, and the property of medicine is more gentle, do not hinder body.

Function cures mainly: treatment rheumatic heart disease anaphase, impurity, dredging vascellum in the cleaning blood vessel are repaired mitral valve function.

Usage and dosage: be used for the rheumatic heart disease treatment later stage, each bag (0.5g), every day 1 time, medicated powder is directly oral.

2. second of the present composition kind of scheme is: by weight ratio is that leading of 1:5-8 organized thing and adminicle is formed.

Wherein, main group thing consists of by weight percentage: Semen Strychni 18%～28%, and Sanguis Draxonis 6%～12%, Rhizoma Cyperi 18%～28%, Olibanum 3%～5%, Myrrha 3%～5%, Cortex Cinnamomi 8%～10%, Pericarpium Citri Reticulatae 6%～10%, Rhizoma Chuanxiong 8%～12%,

The percentage by weight sum of main each raw material of group thing is 100%.

Adminicle consists of by weight percentage: Radix Angelicae Sinensis 6%～12%, Radix Polygoni Ciliinerve 6%～10%, Radix Rehmanniae Preparata 12%～18%, Radix Scutellariae 8%～10%, RADIX ACONITI LATERALIS PREPARATA (system) 4%～8%, Radix Saposhnikoviae 8%～12%, Ramulus Cinnamomi 8%～12%, Radix Glycyrrhizae 3%～7%, Herba Ephedrae 6%～12%, Fructus Aurantii 8%～12%, Radix Aconiti (system) 2%～5%, Fructus Corni 15%～20%, the percentage by weight sum of each raw material of adminicle is 100%.

The write out a prescription effect of each medicine of Chinese medicine composition of the present invention:

Main group thing: Semen Strychni: removing obstruction in the collateral to relieve pain, dispersing swelling and dissipating binds, be used for anemofrigid-damp arthralgia, be monarch drug.Sanguis Draxonis: promoting blood circulation to remove blood stasis, analgesic therapy hemostasis, expelling pus and promoting granulation; Rhizoma Cyperi: the resolving depression of regulating the flow of vital energy; The shared merit that plays blood circulation promoting regulates qi for ministerial drug of Sanguis Draxonis and Rhizoma Cyperi.Olibanum: be used for coagulation of QI-blood, trusted subordinate's pain; Myrrha: be used for muscles and bones, all pains of trusted subordinate; Cortex Cinnamomi: mend supporing yang, the dispersing cold for relieving pain of fire; Olibanum, Myrrha, Cortex Cinnamomi help monarch, ministerial drug with assistant, and promoting blood circulation and stopping pain, the cold-damp of dispeling the wind numbness, benefit fire are with being adjuvant drug.Pericarpium Citri Reticulatae: regulating qi-flowing for strengthening spleen, transfer in, dampness, reduce phlegm, with controlling the abdominal distention uncomfortable in chest in the turbid damp resistance, the cough and asthma of phlegm-damp heap soil or fertilizer over and around the roots lung; Rhizoma Chuanxiong: blood-activating and qi-promoting, wind-expelling pain-stopping are used for rheumatic arthralgia; Pericarpium Citri Reticulatae and Rhizoma Chuanxiong are messenger drug altogether, and drug effect is more strong and powerful, and the property of medicine is more gentle, do not hinder body.

Adminicle: Radix Angelicae Sinensis: enrich blood; Radix Polygoni Ciliinerve: clearing away heat and cooling blood; Radix Rehmanniae Preparata: the yin nourishing of enriching blood; Radix Scutellariae: heat clearing and damp drying; RADIX ACONITI LATERALIS PREPARATA (system): warming and recuperating the spleen and kidney; Radix Saposhnikoviae: expelling pathogenic wind from the body surface, removing dampness to relieve pain; Ramulus Cinnamomi: diaphoresis expelling pathogenic factors from muscles, dispersing cold for relieving pain; Radix Glycyrrhizae: invigorating the spleen and replenishing QI,, expelling phlegm for arresting cough; Herba Ephedrae: diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema; Fructus Aurantii: diuresis; Radix Aconiti (system): expelling wind and removing dampness, antalgic; Fructus Corni: liver and kidney tonifying, essence astringing and desertion stemming.

Take a broad view of full side, be based on taking into account the resolving depression of regulating the flow of vital energy, controlling cough and asthma to invigorate blood circulation, to enrich blood, pain relieving, to remove rheumatic arthralgia, inducing diuresis to remove edema, it is tight make laws, and treating both the principal and secondary aspects of a disease has been caught and has been prevented and treated rheumatic heart disease.

Function cures mainly: treatment rheumatic heart disease anaphase, impurity, dredging vascellum in the cleaning blood vessel are repaired mitral valve function and the double emphysema of controlling.

Usage and dosage: be used for the treatment of rheumatic heart disease, once take main prescription 0.5g, auxiliary prescription 2.5g, every day 2 times, medicated powder is directly oral.

Two, pharmacodynamic experiment:

Experimental technique:

Select mice for use, male and female half and half are divided into 6 groups at random, 20 every group.First group is the normal control group, gives normal saline; Second group of positive matched group is with rheumatic heart medicine Folium Digitalis Purpureae; Organize thing treatment group for Chinese medicine master of the present invention for the 3rd group, give Chinese medicine active ingredient composition of the present invention; Fourth, fifth, six groups are pharmaceutical composition of the present invention (main group thing adds adminicle) treatment group, and give Chinese medicine composition of the present invention: main group thing and adminicle proportioning are respectively 1:5,1:6,1:8.

Except that the normal control group, all the other groups are irritated the food chloroform to mice and are caused atrial fibrillation.Reveal any symptoms is for sitting up round the clock, is off one's feed, movable obviously increasing have irritated feature, forms the rheumatic heart disease symptoms.Respectively positive controls and Chinese medicine composition group of the present invention are irritated the food administration, every day twice, continuous 14 days, the experiment triplicate, experimental session is observed the ordinary circumstance of mice every day.Observation shows: positive controls mice symptom disappears substantially, but also has irritated feature; Third and fourth, five, six groups of Chinese medicine compositions of the present invention can obviously improve the general situation of mice, spirit takes a turn for the better, appetite increases, and is movable normal.

The result shows: Chinese medicine composition of the present invention has therapeutical effect significantly to rheumatic heart disease atrial fibrillation phenomenon.

Three, toxicity test

1. acute toxicity test

Get 10 of white mice, body weight 18-20g, rat, body weight 120-150g, fasting is 8 hours before the administration, can't help water, according to the weight, only irritates stomach 0.8ml/; 10 of rat, water is can't help in fasting 8 hours, only irritates stomach 3ml/ according to the weight, during test mice is divided into groups immediately.First kind of Chinese medicine composition effective ingredient of the present invention, the main group thing of second kind of pharmaceutical composition of the present invention (main group thing adds adminicle) and adminicle proportioning are respectively 1:5,1:6,1:8, observe the mice response situation respectively after the administration immediately, observed 7 days continuously, 20 mice outward appearance sign no abnormality seens, activity freely, feed, drinking-water, feces are all normal, do not have obvious toxic reaction.

2. long term toxicity test

(1) healthy white rat, body weight 120-150g, male and female half and half, grouping immediately, first kind, second kind Chinese medicine composition group of matched group and the present invention, each is organized number and equates, observes a week before the experiment, observes that it is all normal,

(2) route of administration and time: adopt the mode of irritating stomach.Successive administration 30 days, 9-10 point administration every day.Dosage is divided into three dosage, and high dose group, middle dosage group, low dose group are equivalent to clinical people respectively to be intended 50,25,15 times of consumption and irritate stomach, and dosage is 2ml/100g, adjusts dosage according to the body weight situation weekly, not isoconcentration administration such as usefulness capacity such as grade.Last giving was subjected to behind the reagent thing 24 hours, and 10 rats are killed in every group of works, and male and female half and half are with the relatively more equal no significant difference of matched group.After 2 weeks of drug withdrawal, the rat that lives and stay does not extremely more all have significant difference with matched group again.

Experiment conclusion: experimental session is observed: weigh weekly once during the administration, amount drinking-water appetite is all normal, and weight increase does not have dead or dying animal, does not relatively have significant difference with matched group.In view of the above, in 30 days long term toxicity test of rat oral gavage administration, do not find tangible toxic reaction and retardance toxic reaction.

Four, clinical observation

1) treatment rheumatic heart disease 202 examples, pulmonary heart disease 110 examples, emphysema (obstructive pulmonary disease syndrome) 100 examples, diagnosis basis: 1. male, the woman; 2. rheumatic heart disease symptoms: feel cold in extremity and back, irritable feverish sensation in the chest, and lower limbs edema, it is white to see its red tongue tongue, and pulse is thin, little phenomenon such as have intermittently, breathe hard.

2) efficacy assessment standard

Recovery from illness: edema, cardiopalmus, breathe hard, sleep, all diseases are normal; Produce effects: the atrial fibrillation phenomenon disappears substantially, and heavy elephant of chi pulse makes moderate progress, and it is closely gentle to breathe hard, and sleep, diet all are greatly improved; Effectively: improve a lot the intermittence of pulse, but the improvement of chi pulse phenomenon is not obvious; Invalid: no change before and after the treatment.

3), the present invention uses through clinical practice, clinical practice is summed up, and sees Table as follows:

As seen from the above table: utilizing traditional Chinese medicine composition for treating total effective rate of the present invention is 98.54%.Effective percentage to the rheumatic heart disease treatment is 99.0%, and the inefficiency that rheumatic heart disease is treated is 0.99%, illustrates that Chinese medicine composition of the present invention has therapeutical effect to rheumatic heart disease.

The clinical treatment case:

One. patient Huang Dairong, the woman, 20 years old, look wane and sallow, absentminded is examined its arteries and veins, a left side cun, closes thready pulse, number and intermittently, chi pulse is heavy, little, right cun, close thready pulse and have the string meaning concurrently, near heavy little.According to pulse condition, it is cool to ask whether she likes the heat fear, and answer is yes.Readme: morning yesterday has been outdoor stayed for a moment more, just has afternoon a kind ofly ineffablely to feel bad, breathe hard, the time and also shudder, extremity have slight tic phenomenon.When this situation occurring, her household is very frightened, be just out of hospital before saying two days, after catching a cold repeatedly as before, analysis of cases: with after catching a cold repeatedly, pulse phenomenon such as has intermittently, breathes hard as can be known, this is not simple atrial fibrillation, is the rheumatic heart disease atrial fibrillation of holding concurrently in fact.This is had a cold by heart body and is fought mutually with damp and hot, influences the MC imbalance, and the blood reflux conductance causes breathes hard.Prescription is for Chinese medicine composition of the present invention, and after two doses, three doses, various symptoms continue to improve, and two examine: patient's readme: do not have originally more at heart and feel bad like that.Intermittence of pulse improves a lot, have only chi pulse heavy resemble not obvious.Its essence is: wind and cold does not obtain by removing, and should strengthen by cold dynamics, makes wind and cold appear off-balancesheet.On former prescription, add Radix Aconiti 5g, obey three doses again.Three examine: the atrial fibrillation phenomenon disappears substantially, and it is closely gentle to breathe hard, and sleep, diet all have greatly improved, and it is still heavy, slow to have chi pulse only.This explanation cold is not thoroughly driven away, and continues to take Chinese medicine composition of the present invention.The four diagnostic methods, the phenomenon of chi pulse makes moderate progress, but state also be not very desirable, very little, GUAN-pulse is closely gentle, obeys this medicine again, recovers substantially after the four diagnostic methods, continues to take one month, just thoroughly cure.

Two. patient Liu, the man, 50 years old (2003) before 15 years, because of cardiopalmus, breathe hard, are diagnosed as rheumatic heart disease.Long-term prescription is kept, the time heavy when light.Patient's readme: it is poor to sleep, and feels cold in extremity and back, irritable feverish sensation in the chest, and distension under the rib, lower limbs edema are more so.It is white to see its red tongue tongue; Examine its arteries and veins, two chi portions are all heavy thin, close thready pulse, number, and the area on the wrist over the radial artery where the pulse is felt for diagnosis is flickering.From thready pulse, as can be known little, patient's severe ischemic, blood failing to tonify the heart is so heart failure as for mitral incompetence, is the result of rheumatism invasion and attack.Because the periosteum of Bicuspid valve and human synovial is similar, the joint deformity of rheumatism skelalgia and the distortion of rheumatoid articulations digitorum manus form for the periosteum deformity in fact.The treatment Bicuspid valve, medication need cooperate the guiding drug sick institute that go directly, the ability safety and precise reach therapeutic purposes.Treatment prescription is a Chinese medicine composition of the present invention, and two examine: readme sleep makes moderate progress, and shortness of breath and palpitation is also alleviated to some extent, and patient's confidence heightens, and that the swelling has gone down is a lot of for water after three doses, imitates more not square.Three examine: extremity have been felt heating, and only finger, toe are also felt and sent out coolly, advance three doses again.The four diagnostic methods: all diseases continue to take a turn for the better, but four tips also feel cool.Continue to take, after 24 doses, edema, cardiopalmus, breathe hard, sleep, all diseases are normal substantially, but feel wind and cold slightly, cardiopalmus, the symptom of breathing hard also can occur, but not serious in the past, continue administration,, make the patient recover health of heart with thorough reparation mitral incompetence.Visit so far, healthy, there is not bounce-back again.

Three. patient Song Yu virtue woman 67 years old Yan Fu County octadentate people from village, Yang Quan town first visit in January, 2009.Examine its arteries and veins, right floating pulse, number and have intermittently, left floating pulse, number, tight, have intermittently, know that its cardiovascular is narrow, sputum blocks the lung key, thick fur, yellow slightly, red tongue margin, the bright stomach internal organs of sun must not be shown diffusingly and red-hot because of affection of exogenous wind-cold, and stifling then cardiopulmonary are heated, and red tongue margin is " wind-cold tightening the lung " as can be known.Patient's daughter informs the author, and it is female suffered from this disease 8 years.Calendar year 2001, the city-level hospital diagnosis is emphysema, is never well treated.According to above pulse condition and the extremely difficult present situation of patient respiratory, take resolute measure.Prescription: Chinese medicine composition of the present invention, three doses, be decocted in water for oral dose, two examine: arteries and veins is not floating tight, still has intermittently in the number, and thick fur, Huang are not obvious.From speech, breathe gradually behind the hac nocte sumendus Chinese medicine composition of the present invention and take a turn for the better.Three examine: patient oneself comes to get it filled, and continues administration 30 days, examines its arteries and veins, and is closely gentle, but still has intermittently.Continue to take medicine of the present invention and visit drug withdrawal so far thereafter, never rebound phenomena with kind.

Embodiment 1

Take by weighing Semen Strychni 25g(25%), Sanguis Draxonis 10g(10%), Rhizoma Cyperi 25g(25%), Olibanum 5g(5%), Myrrha 5g(5%), Cortex Cinnamomi 10g(10%), Pericarpium Citri Reticulatae 10g(10%), Rhizoma Chuanxiong 10g(10%), above eight flavor spices are got all the ready respectively by weight, carry out remove impurity, drying, pulverizing, mix homogeneously, make medicated powder with being ground into fine powder, can be directly oral.

Embodiment 2

Take by weighing Semen Strychni 56g(28%), Sanguis Draxonis 12g(6%), Rhizoma Cyperi 56g(28%), Olibanum 8g(4%), Myrrha 8g(4%), Cortex Cinnamomi 18g(9%), Pericarpium Citri Reticulatae 18g(9%), Rhizoma Chuanxiong 24g(12%), above eight flavor spices are got all the ready respectively by weight, carry out remove impurity, drying, pulverizing, mix homogeneously, make medicated powder with being ground into fine powder, can be directly oral.

Embodiment 3

Take by weighing Semen Strychni 56g(28%), Sanguis Draxonis 24g(12%), Rhizoma Cyperi 56g(28%), Olibanum 6g(3%), Myrrha 6g(3%), Cortex Cinnamomi 16g(8%), Pericarpium Citri Reticulatae 12g(6%), Rhizoma Chuanxiong 24g(12%), above eight flavor spices are got all the ready respectively by weight, carry out remove impurity, drying, pulverizing, mix homogeneously, make medicated powder with being ground into fine powder, can be directly oral.

Embodiment 4

Take by weighing Semen Strychni 36g(18%), Sanguis Draxonis 24g(12%), Rhizoma Cyperi 56g(28%), Olibanum 10g(5%), Myrrha 10g(5%), Cortex Cinnamomi 20g(10%), Pericarpium Citri Reticulatae 20g(10%), Rhizoma Chuanxiong 24g(12%), above eight flavor spices are got all the ready respectively by weight, carry out remove impurity, drying, pulverizing, mix homogeneously, make medicated powder with being ground into fine powder, can be directly oral.

Embodiment 5

Take by weighing Semen Strychni 56g(28%), Sanguis Draxonis 24g(12%), Rhizoma Cyperi 36g(18%), Olibanum 10g(5%), Myrrha 10g(5%), Cortex Cinnamomi 20g(10%), Pericarpium Citri Reticulatae 20g(10%), Rhizoma Chuanxiong 24g(12%), above eight flavor spices are got all the ready respectively by weight, carry out remove impurity, drying, pulverizing, mix homogeneously, make medicated powder with being ground into fine powder, can be directly oral.

Embodiment 6

Take by weighing Semen Strychni 56g(28%), Sanguis Draxonis 12g(6%), Rhizoma Cyperi 56g(28%), Olibanum 10g(5%), Myrrha 10g(5%), Cortex Cinnamomi 20g(10%), Pericarpium Citri Reticulatae 20g(10%), Rhizoma Chuanxiong 16g(8%), above eight flavor spices are got all the ready respectively by weight, carry out remove impurity, drying, pulverizing, mix homogeneously, make medicated powder with being ground into fine powder, can be directly oral.

Embodiment 7

Main group thing: take by weighing Semen Strychni 25g(25%), Sanguis Draxonis 10g(10%), Rhizoma Cyperi 25g(25%), Olibanum 5g(5%), Myrrha 5g(5%), Cortex Cinnamomi 10g(10%), Pericarpium Citri Reticulatae 10g(10%), Rhizoma Chuanxiong 10g(10%), above eight flavor spices are got all the ready respectively by weight, carry out remove impurity, drying, pulverizing, mix homogeneously, to make medicated powder standby with being ground into fine powder.

Adminicle: take by weighing Radix Angelicae Sinensis 60g(12%), Radix Polygoni Ciliinerve 35g(7%), Radix Rehmanniae Preparata 65g(13%), Radix Scutellariae 40g(8%), RADIX ACONITI LATERALIS PREPARATA (system) 40g(8%), Radix Saposhnikoviae 40g(8%), Ramulus Cinnamomi 40g(8%), Radix Glycyrrhizae 15g(3%), Herba Ephedrae 35g(7%), Fructus Aurantii 40g(8%), Radix Aconiti (system) 10g(2%), Fructus Corni 80g(16%).Above 12 flavor spices are got all the ready respectively by weight, carried out remove impurity, drying, pulverizing, mix homogeneously, to make medicated powder standby with being ground into fine powder.

According to main group thing and adminicle weight ratio is the 1:5 proportioning, makes main group thing medicated powder 100g and adminicle medicated powder 500g.

Embodiment 8

Main group thing: take by weighing Semen Strychni 56g(28%), Sanguis Draxonis 12g(6%), Rhizoma Cyperi 56g(28%) and, Olibanum 8g(4%), Myrrha 8g(4%) and, Cortex Cinnamomi 18g(9%), Pericarpium Citri Reticulatae 18(9%) and, Rhizoma Chuanxiong 24g(12%).Above eight flavor spices are got all the ready respectively by weight, carried out remove impurity, drying, pulverizing, mix homogeneously, to make medicated powder standby with being ground into fine powder.

Adminicle: take by weighing Radix Angelicae Sinensis 120g(10%), Radix Polygoni Ciliinerve 120g(10%), Radix Rehmanniae Preparata 216g(18%), Radix Scutellariae 96g(8%), RADIX ACONITI LATERALIS PREPARATA (system) 48g(4%), Radix Saposhnikoviae 96g(8%), Ramulus Cinnamomi 96g(8%), Radix Glycyrrhizae 36g(3%), Herba Ephedrae 72g(6%), Fructus Aurantii 96g(8%), Radix Aconiti (system) 24g(2%), Fructus Corni 180g(15%).Above 12 flavor spices are got all the ready respectively by weight, carried out remove impurity, drying, pulverizing, mix homogeneously, to make medicated powder standby with being ground into fine powder.

According to main group thing and adminicle weight ratio is the 1:6 proportioning, makes main group thing medicated powder 200g and adminicle medicated powder 1200g.

Embodiment 9

Main group thing: take by weighing Semen Strychni 56g(28%), Sanguis Draxonis 24g(12%), Rhizoma Cyperi 56g(28%), Olibanum 6g(3%), Myrrha 6g(3%), Cortex Cinnamomi 16g(8%), Pericarpium Citri Reticulatae 12g(6%), Rhizoma Chuanxiong 24g(12%), above eight flavor spices are got all the ready respectively by weight, carry out remove impurity, drying, pulverizing, mix homogeneously, to make medicated powder standby with being ground into fine powder.

Adminicle: take by weighing Radix Angelicae Sinensis 84g(6%), Radix Polygoni Ciliinerve 84g(6%), Radix Rehmanniae Preparata 168g(12%), Radix Scutellariae 112g(8%), RADIX ACONITI LATERALIS PREPARATA (system) 56g(4%), Radix Saposhnikoviae 168g(12%), Ramulus Cinnamomi 168g(12%), Radix Glycyrrhizae 42g(3%), Herba Ephedrae 168g(12%), Fructus Aurantii 112g(8%), Radix Aconiti (system) 28g(2%), Fructus Corni 210g(15%), above 12 flavor spices are got all the ready respectively by weight, carry out remove impurity, drying, pulverizing, mix homogeneously, to make medicated powder standby with being ground into fine powder.

According to main group thing and adminicle weight ratio is the 1:7 proportioning, makes main group thing medicated powder 200g and adminicle medicated powder 1400g.

Embodiment 10

Main group thing: take by weighing Semen Strychni 36g(18%), Sanguis Draxonis 24g(12%), Rhizoma Cyperi 56g(28%), Olibanum 10g(5%), Myrrha 10g(5%), Cortex Cinnamomi 20g(10%), Pericarpium Citri Reticulatae 20g(10%), Rhizoma Chuanxiong 24g(12%), above eight flavor spices are got all the ready respectively by weight, carry out remove impurity, drying, pulverizing, mix homogeneously, to make medicated powder standby with being ground into fine powder.

Adminicle: take by weighing Radix Angelicae Sinensis 96g(6%), Radix Polygoni Ciliinerve 96g(6%), Radix Rehmanniae Preparata 192g(12%), Radix Scutellariae 160g(10%), RADIX ACONITI LATERALIS PREPARATA (system) 80g(5%), Radix Saposhnikoviae 160g(10%), Ramulus Cinnamomi 160g(10%), Radix Glycyrrhizae 112g(7%), Herba Ephedrae 96g(6%), Fructus Aurantii 160g(10%), Radix Aconiti (system) 48g(3%), Fructus Corni 240g(15%).Above 12 flavor spices are got all the ready respectively by weight, carried out remove impurity, drying, pulverizing, mix homogeneously, to make medicated powder standby with being ground into fine powder.

According to main group thing and adminicle weight ratio is the 1:8 proportioning, makes main group thing medicated powder 200g and adminicle medicated powder 1600g.

Embodiment 11

Main group thing: take by weighing Semen Strychni 56g(28%), Sanguis Draxonis 24g(12%), Rhizoma Cyperi 36g(18%), Olibanum 10g(5%), Myrrha 10g(5%), Cortex Cinnamomi 20g(10%), Pericarpium Citri Reticulatae 20g(10%), Rhizoma Chuanxiong 24g(12%), above eight flavor spices are got all the ready respectively by weight, carried out remove impurity, drying, pulverizing, mix homogeneously, to make medicated powder standby with being ground into fine powder.

Adminicle: take by weighing Radix Angelicae Sinensis 60g(6%), Radix Polygoni Ciliinerve 60g(6%), Radix Rehmanniae Preparata 120g(12%), Radix Scutellariae 90g(9%), RADIX ACONITI LATERALIS PREPARATA (system) 40g(4%), Radix Saposhnikoviae 80g(8%), Ramulus Cinnamomi 80g(8%), Radix Glycyrrhizae 40g(4%), Herba Ephedrae 60g(6%), Fructus Aurantii 120g(12%), Radix Aconiti (system) 50g(5%), Fructus Corni 200g(20%).Above 12 flavor spices are got all the ready respectively by weight, carried out remove impurity, drying, pulverizing, mix homogeneously, to make medicated powder standby with being ground into fine powder.

According to main group thing and adminicle weight ratio is the 1:5 proportioning, makes main group thing medicated powder 200g and adminicle medicated powder 1000g.

Embodiment 12

Main group thing: take by weighing Semen Strychni 56g(28%), Sanguis Draxonis 12g(6%), Rhizoma Cyperi 56g(28%), Olibanum 10g(5%), Myrrha 10g(5%), Cortex Cinnamomi 20g(10%), Pericarpium Citri Reticulatae 20g(10%), Rhizoma Chuanxiong 16g(8%), above eight flavor spices are got all the ready respectively by weight, carry out remove impurity, drying, pulverizing, mix homogeneously, to make medicated powder standby with being ground into fine powder.

Adminicle: take by weighing Radix Angelicae Sinensis 72g(6%), Radix Polygoni Ciliinerve 72g(6%), Radix Rehmanniae Preparata 144g(12%), Radix Scutellariae 108g(9%), RADIX ACONITI LATERALIS PREPARATA (system) 48g(4%), Radix Saposhnikoviae 96g(8%), Ramulus Cinnamomi 96g(8%), Radix Glycyrrhizae 48g(4%), Herba Ephedrae 72g(6%), Fructus Aurantii 144g(12%), Radix Aconiti (system) 60g(5%), Fructus Corni 240g(20%).Above 12 flavor spices are got all the ready respectively by weight, carried out remove impurity, drying, pulverizing, mix homogeneously, to make medicated powder standby with being ground into fine powder.

According to main group thing and adminicle weight ratio is the 1:6 proportioning, makes main group thing medicated powder 200g and adminicle medicated powder 1200g.

Claims (4)

1. Chinese medicine composition for the treatment of rheumatic heart disease, it is characterized in that, wherein making raw materials of effective components consists of by weight percentage: Semen Strychni 18%～28%, Sanguis Draxonis 6%～12%, Rhizoma Cyperi 18%～28%, Olibanum 3%～5%, Myrrha 3%～5%, Cortex Cinnamomi 8%～10%, Pericarpium Citri Reticulatae 6%～10%, Rhizoma Chuanxiong 8%～12%, the percentage by weight sum of each raw material is 100%.

2. a preparation method for the treatment of the Chinese medicine composition of rheumatic heart disease is characterized in that, gets Semen Strychni 18%～28% by weight percentage, Sanguis Draxonis 6%～12%, Rhizoma Cyperi 18%～28%, Olibanum 3%～5%, Myrrha 3%～5%, Cortex Cinnamomi 8%～10%, Pericarpium Citri Reticulatae 6%～10%, Rhizoma Chuanxiong 8%～12%, more than the percentage by weight sum of each raw material be 100%, above eight kinds of raw materials are carried out remove impurity, drying, pulverizing, mix homogeneously, make medicated powder with being ground into fine powder.

3. a Chinese medicine composition for the treatment of rheumatic heart disease is characterized in that, this Chinese medicine composition is that leading of 1:5-8 organized thing and adminicle is formed by weight ratio, wherein,

Main group thing consists of by weight percentage: Semen Strychni 18%～28%, Sanguis Draxonis 6%～12%, Rhizoma Cyperi 18%～28%, Olibanum 3%～5%, Myrrha 3%～5%, Cortex Cinnamomi 8%～10%, Pericarpium Citri Reticulatae 6%～10%, Rhizoma Chuanxiong 8%～12%, the percentage by weight sum of main each raw material of group thing is 100%;

Adminicle consists of by weight percentage: Radix Angelicae Sinensis 6%～12%, Radix Polygoni Ciliinerve 6%～10%, Radix Rehmanniae Preparata 12%～18%, Radix Scutellariae 8%～10%, RADIX ACONITI LATERALIS PREPARATA (system) 4%～8%, Radix Saposhnikoviae 8%～12%, Ramulus Cinnamomi 8%～12%, Radix Glycyrrhizae 3%～7%, Herba Ephedrae 6%～12%, Fructus Aurantii 8%～12%, Radix Aconiti (system) 2%～5%, Fructus Corni 15%～20%, the percentage by weight sum of each raw material of adminicle is 100%.

4. a preparation method for the treatment of the Chinese medicine composition of rheumatic heart disease is characterized in that, this method is carried out as follows:

Step 1, the main group of preparation thing

Get Semen Strychni 18%～28% by weight percentage respectively, Sanguis Draxonis 6%～12%, Rhizoma Cyperi 18%～28%, Olibanum 3%～5%, Myrrha 3%～5%, Cortex Cinnamomi 8%～10%, Pericarpium Citri Reticulatae 6%～10%, Rhizoma Chuanxiong 8%～12%, the percentage by weight sum of main each raw material of group thing is 100%, carry out remove impurity, drying, pulverizing, mix homogeneously, to make medicated powder standby with being ground into fine powder;

Step 2, the preparation adminicle

Get Radix Angelicae Sinensis 6%～12% by weight percentage respectively, Radix Polygoni Ciliinerve 6%～10%, Radix Rehmanniae Preparata 12%～18%, Radix Scutellariae 8%～10%, RADIX ACONITI LATERALIS PREPARATA (system) 4%～8%, Radix Saposhnikoviae 8%～12%, Ramulus Cinnamomi 8%～12%, Radix Glycyrrhizae 3%～7%, Herba Ephedrae 6%～12%, Fructus Aurantii 8%～12%, Radix Aconiti (system) 2%～5%, Fructus Corni 15%～20%, the percentage by weight sum of each raw material of adminicle is 100%, carry out remove impurity, drying, pulverizing, mix homogeneously, to make medicated powder standby with being ground into fine powder;

Step 3

Main group thing that step 1 and step 2 are prepared and adminicle medicated powder are with 1:5-8 ratio compatibility.

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