CN1615939A - Chinese medicine prescription for breating diabetes retina pathologic change - Google Patents
Chinese medicine prescription for breating diabetes retina pathologic change Download PDFInfo
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- CN1615939A CN1615939A CN 200410012534 CN200410012534A CN1615939A CN 1615939 A CN1615939 A CN 1615939A CN 200410012534 CN200410012534 CN 200410012534 CN 200410012534 A CN200410012534 A CN 200410012534A CN 1615939 A CN1615939 A CN 1615939A
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Abstract
The present invention relates to Chinese medicine preparing technology, and is especially a kind of Chinese medicine preparation for treating pathologic change. The Chinese medicine preparation is prepared with 12 kinds of Chinese medicinal materials, including rehmannia root, anemarrhena rhizome, figwort, astragalus root, notoginseng, etc. in certain proportion. The Chinese medicine preparation has double functions of treating diabetes and retina disease.
Description
Technical field:
The present invention relates to the Chinese medicine preparation technique, particularly a kind of Chinese medicinal formulae for the treatment of diabetic retinopathy.
Background technology:
Diabetes are the general commonly encountered diseases based on carbohydrate metabolism disturbance.The population of China sickness rate is about 1%, and diabetic retinopathy (it is sick to be called for short the sugar net) is one of severe complication of diabetes.According to document announcement, in diabetics, sugar net patient is taken place and is reached more than 50% in morbidity 10-15, become common, frequently-occurring disease, do not find at present safe, effective, economic medicine clinically as yet, but adopt multiple single therapy effect in, the comprehensive drug treatment of Western medicine, the drawback of its existence is: can not play the effect for the treatment of both the principal and secondary aspects of a disease; The accumulate poisoning phenomenon in use appears in some medicine easily; Cross reaction between the medicine appears in the medication process easily; Adverse reaction rate is higher; Drug price is higher.
Summary of the invention:
Purpose of the present invention is intended to solve the drawback of above-mentioned background technology, and provide a kind of diabetes and retinal diseases is had the double treatment function, and has the Chinese medicinal formulae of the treatment diabetic retinopathy for the treatment of both the principal and secondary aspects of a disease, safety economy characteristics.
The technical scheme that realizes this goal of the invention is: the drug component and the percentage by weight thereof of this Chinese medicinal formulae are: the Radix Rehmanniae 6.85～10.27, the Rhizoma Anemarrhenae 6.85～10.27, Radix Scrophulariae 6.85～10.27, the Radix Astragali 6.85～20.55, Radix Notoginseng powder 2.05～6.85, Cortex Phellodendri 2.05～8.22, Rhizoma Atractylodis 3.43～8.22, Semen Cassiae 10.27～20.55, Radix Salviae Miltiorrhizae 6.85～13.70, Sargassum 4.11～8.22, Thallus Laminariae (Thallus Eckloniae) 4.11～8.22, river cattle sunset 4.11～10.27.
The technical scheme that realizes this goal of the invention can also be: the drug component and the percentage by weight thereof of this Chinese medicinal formulae are: the Radix Rehmanniae 8.56, the Rhizoma Anemarrhenae 8.56, Radix Scrophulariae 8.56, the Radix Astragali 13.70, Radix Notoginseng powder 4.45, Cortex Phellodendri 5.13, Rhizoma Atractylodis 5.82, Semen Cassiae 15.40, Radix Salviae Miltiorrhizae 10.27, Sargassum 6.16, Thallus Laminariae (Thallus Eckloniae) 6.16, river cattle sunset 7.19.
According to the configuration proportion of prescription of the present invention, adopt advanced Chinese medicine preparation production technology, this medicine can be made granule, the medicine name is called for short " sugared net granule ", and it is packed to press one time oral dose 10g, and clothes were three times in general day, or abided by testament.
The Chinese medicinal formulae of treatment diabetic retinopathy of the present invention, its prescription is according to being: modern medicine is thought, diabetes spp traditional Chinese medical science diabetes category, this disease deficiency of YIN is this, scorching for marking, delay is deficiency of both QI and YIN with the passing of time then, deficiency of both YIN and YANG.Diabetic retinopathy claims blurring of vission again, and retina is at the five ratation schools genus water wheels that are right, by kidney is led.Blurring of vission becomes varied because of its internal ophthalmopathy, in conjunction with whole body then pathological changes have void that reality is arranged, simulataneous insufficiency and excessive, but should disease this for empty, to be designated as tangible different phase clinical manifestation different, but should be method with nourishing YIN and clearing away heat, promoting blood circulation to remove obstruction in the collateral totally.Weak or the course of disease is long as the patient, should help product with the short spleen of QI invigorating.The present invention is according to the above cause of disease mechanism, in line with invigorating blood circulation, and hemostasis and not being detained, collateral dredging makes eye bright and does not hinder positive principle, controls and intends side in conjunction with whole dialectical executing with local.The Radix Rehmanniae, Radix Scrophulariae heat clearing away in the side, establish the yang function, promote the production of body fluid, Rhizoma Anemarrhenae heat clearing away, YIN nourishing, moisturize, Radix Salviae Miltiorrhizae, Radix Notoginseng powder, river cattle sunset collateral dredging disappear stagnant, Cortex Phellodendri heat clearing away, dampness removing, detumescence, Semen Cassiae liver heat removing and eyesight improving, the Radix Astragali, the short spleen, inducing diuresis and reducing edema of Rhizoma Atractylodis QI invigorating, Thallus Laminariae (Thallus Eckloniae), Sargassum hard masses softening and resolving, all flavor Chinese medicine is played the merit of nourishing YIN and clearing away heat, blood circulation-activating eyesight-improving altogether, and it is sick to be used for the treatment of the sugar net, blurred vision, disease such as Light-headedness due to the deficiency of YIN is scorching; Be used for retinal hemorrhage, ooze out, auxiliary treatment such as proliferative vitreous body, retinopathy and vitrectomy postoperative, retinal detachment surgery.
Chinese medicinal formulae of the present invention---" sugared net granule " observed through 1000 routine patient's clinical trials to affiliated indication over the past two years, any toxic reaction do not occur, its observation of curative effect result such as following table.
1000 example sugar net sick I～IV phase patient observation of curative effect tables
| Group | The eye number | Significant effective | Produce effects | Invalid | Total effective rate |
| The sugar sick I phase of net | ??110 | ??105 | ??3 | ??2 | ??98.18％ |
| The sugar sick II phase of net | ??230 | ??204 | ??11 | ??15 | ??93.48％ |
| The sugar sick III phase of net | ??360 | ??278 | ??37 | ??45 | ??87.50％ |
| The sugar sick IV phase of net | ??300 | ??190 | ??42 | ??68 | ??77.33％ |
| Sum | ??1000 |
Therapeutic scheme: the sick I phase of sugar net took medicine three months continuously, and a further consultation in month once or follow the doctor's advice at interval; The sick II phase of sugar net took medicine three months continuously, and a further consultation in month once or follow the doctor's advice at interval; The sick III phase of sugar net took medicine six months continuously, and a further consultation in month once or follow the doctor's advice at interval; The sick IV phase of sugar net took medicine six months continuously, and a further consultation in month once or follow the doctor's advice at interval.
Model case:
Case 1 (sugar net sick I phase): the woman, 55 years old, the main suit continued toward diabetic history 10 years, and the shadow institute of waving over 4 months goes to a doctor before the eyes.Through looking into: V
A left side=0.3, V
Right=0.4, cornea of both eyes is transparent, and is dark among the anterior chamber, and crystal is slightly muddy, and vitreous body is not seen obvious muddiness, the clear color in optic disc limit, optical fundus can, A, V intersect and levy the positive, nethike embrane is dispersed in microangioma and is dispersed in little petechia, the macular area foveal reflex is not seen.Treatment: take sugared net granule continuously after three months, look into again: V
A left side=0.4, V
Right=0.5, be dispersed in little petechia and disappear.
Case 2 (sugar net sick II phase): the man, 60 years old, the main suit continued toward diabetic history 10 years, the eyes blurring of vision over 3 months institute go to a doctor.Through looking into: V
A left side=0.25, V
Right=0.2, binocular lense is slightly muddy, and surplus prosthomere shows no obvious abnormalities, and nethike embrane has a small amount of rigid oozing out, and is yellow-white, clear-cut margin, and ecchymosis is arranged, the FFA prompting eyes sugar sick II phase of net.Treatment: take sugared net granule continuously after 3 months, look into again: V
A left side=0.4, V
Right=0.5, ecchymosis disappears, and yellow-white is rigid to ooze out minimizing.
Case 3 (sugar net sick III phase): the woman, 62 years old, the main suit continued toward diabetic history 12 years, and eyes blurring of vision institute is over the past half year gone to a doctor.Through looking into: V
A left side=0.25, V
Right=0.3, cornea of both eyes is transparent, and is dark among the anterior chamber, and crystal is slightly muddy, and surplus prosthomere shows no obvious abnormalities, optical fundus visible " soft oozing out " is positioned at macula lutea temporo side, is white in color the 1/2-1PO size, the border is clear, the velveteen shape, and ecchymosis is arranged, the FFA prompting eyes sugar sick III phase of net.Treatment: take sugared net granule continuously after 6 months, conscious to look thing gradually clear, and white is soft oozes out minimizing, and ecchymosis obviously reduces.
Case 4 (sugar net sick IV phase): the man, 58 years old, the main suit continued toward diabetic history 12 years, binocular vision descend two weeks institute go to a doctor.Through looking into: V
A left side=0.5, V
Right=0.1, cornea of both eyes is transparent, and crystal is transparent, the a small amount of hematocele of right eye vitreous body, optical fundus as seen, optic disc temporo side nethike embrane sheet is hemorrhage, be radial, macular area is got involved, at the bottom of the left eye visible " soft oozing out ", be white in color, the velveteen shape has a small amount of ecchymosis, the FFA prompting, left eye is the sugar sick III phase of net, and right eye is the sugar sick IV phase of net.Treatment: take sugared net granule continuously after 6 months, the white soft minimizing of oozing of left eye, ecchymosis obviously reduces, right eye optic disc temporo side nethike embrane absorption of hemorrhage, vitreous hemorrhage absorbs, and ecchymosis obviously reduces.
The specific embodiment:
Below provide six concrete (prescriptions) belonging to prescription configuration proportion of the present invention
Embodiment sees the following form.
Diabetic retinopathy Chinese medicinal formulae formula table
| Component | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 | ||||||
| Weight g | Content % | Weight g | Content % | Weight g | Content % | Weight g | Content % | Weight g | Content % | Weight g | Content % | |
| The Radix Rehmanniae | 12.5 | 8.56 | 10 | ??6.85 | 15 | 10.27 | 13 | ?8.91 | ?12 | ?8.22 | ?15 | ?10.27 |
| The Rhizoma Anemarrhenae | 12.5 | 8.56 | 10 | ??6.85 | 10 | 6.85 | 12 | ?8.22 | ?14 | ?9.59 | ?15 | ?10.27 |
| Radix Scrophulariae | 12.5 | 8.56 | 12 | ??8.22 | 10 | 6.85 | 15 | ?10.27 | ?14 | ?9.59 | ?15 | ?10.27 |
| The Radix Astragali | 20 | 13.70 | 10 | ??6.85 | 30 | 20.55 | 25 | ?17.12 | ?20 | ?13.70 | ?15 | ?10.27 |
| Radix Notoginseng powder | 6.5 | 4.45 | 10 | ??6.85 | 3 | 2.05 | 5 | ?3.43 | ?8 | ?5.48 | ?8 | ?5.48 |
| Cortex Phellodendri | 7.5 | 5.13 | 12 | ??8.22 | 5 | 3.43 | 3 | ?2.05 | ?8 | ?5.48 | ?10 | ?6.85 |
| Rhizoma Atractylodis | 8.5 | 5.82 | 12 | ??8.22 | 5 | 3.43 | 9 | ?6.16 | ?7 | ?4.79 | ?11 | ?7.54 |
| Semen Cassiae | 22.5 | 15.40 | 30 | ??20.54 | 15 | 10.27 | 18 | ?12.33 | ?25 | ?17.12 | ?17 | ?11.65 |
| Radix Salviae Miltiorrhizae | 15 | 10.27 | 10 | ??6.85 | 20 | 13.70 | 18 | ?12.33 | ?14 | ?9.59 | ?14 | ?9.59 |
| Sargassum | 9 | 6.16 | 6 | ??4.11 | 12 | 8.22 | 10 | ?6.85 | ?8 | ?5.48 | ?8 | ?5.48 |
| Thallus Laminariae (Thallus Eckloniae) | 9 | 6.16 | 12 | ??8.22 | 6 | 4.11 | 12 | ?8.22 | ?8 | ?5.48 | ?8 | ?5.48 |
| River Niu Xi | 10.5 | 7.19 | 12 | ??8.22 | 15 | 10.27 | 6 | ?4.11 | ?8 | ?5.48 | ?10 | ?6.85 |
| Add up to | 146 | 100 | 146 | ??100 | 146 | 100 | 146 | ?100 | ?146 | ?100 | ?146 | ?100 |
Claims (2)
1, a kind of Chinese medicinal formulae for the treatment of diabetic retinopathy is characterized in that the drug component of this Chinese medicinal formulae and percentage by weight thereof are: the Radix Rehmanniae 6.85～10.27, the Rhizoma Anemarrhenae 6.85～10.27, Radix Scrophulariae 6.85～10.27, the Radix Astragali 6.85～20.55, Radix Notoginseng powder 2.05～6.85, Cortex Phellodendri 2.05～8.22, Rhizoma Atractylodis 3.43～8.22, Semen Cassiae 10.27～20.55, Radix Salviae Miltiorrhizae 6.85～13.70, Sargassum 4.11～8.22, Thallus Laminariae (Thallus Eckloniae) 4.11～8.22, river cattle sunset 4.11～10.27.
2, the Chinese medicinal formulae of treatment diabetic retinopathy according to claim 1 is characterized in that the drug component of this Chinese medicinal formulae and percentage by weight thereof are: the Radix Rehmanniae 8.56, the Rhizoma Anemarrhenae 8.56, Radix Scrophulariae 8.56, the Radix Astragali 13.70, Radix Notoginseng powder 4.45, Cortex Phellodendri 5.13, Rhizoma Atractylodis 5.82, Semen Cassiae 15.40, Radix Salviae Miltiorrhizae 10.27, Sargassum 6.16, Thallus Laminariae (Thallus Eckloniae) 6.16, river cattle sunset 7.19.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410012534 CN1278723C (en) | 2004-09-17 | 2004-09-17 | Chinese medicine prescription for breating diabetes retina pathologic change |
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|---|---|---|---|
| CN 200410012534 CN1278723C (en) | 2004-09-17 | 2004-09-17 | Chinese medicine prescription for breating diabetes retina pathologic change |
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| CN1615939A true CN1615939A (en) | 2005-05-18 |
| CN1278723C CN1278723C (en) | 2006-10-11 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410012534 Expired - Fee Related CN1278723C (en) | 2004-09-17 | 2004-09-17 | Chinese medicine prescription for breating diabetes retina pathologic change |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101081091B (en) * | 2007-04-25 | 2010-07-28 | 肖自力 | Vision-improving and intelligent-improving beverage |
| CN102631460A (en) * | 2012-03-31 | 2012-08-15 | 北京绿源求证科技发展有限责任公司 | Traditional Chinese medicine (TCM) for treating diabetic retinopathy |
| CN104491476A (en) * | 2015-01-12 | 2015-04-08 | 季宗文 | Medicine for treating yin-deficiency and dryness-heat type diabetic retinopathy and preparation method thereof |
-
2004
- 2004-09-17 CN CN 200410012534 patent/CN1278723C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101081091B (en) * | 2007-04-25 | 2010-07-28 | 肖自力 | Vision-improving and intelligent-improving beverage |
| CN102631460A (en) * | 2012-03-31 | 2012-08-15 | 北京绿源求证科技发展有限责任公司 | Traditional Chinese medicine (TCM) for treating diabetic retinopathy |
| CN104491476A (en) * | 2015-01-12 | 2015-04-08 | 季宗文 | Medicine for treating yin-deficiency and dryness-heat type diabetic retinopathy and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN1278723C (en) | 2006-10-11 |
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