CN1313114A - Medicine for treating female dimacteric syndrome and its preparing process - Google Patents
Medicine for treating female dimacteric syndrome and its preparing process Download PDFInfo
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- CN1313114A CN1313114A CN 01100405 CN01100405A CN1313114A CN 1313114 A CN1313114 A CN 1313114A CN 01100405 CN01100405 CN 01100405 CN 01100405 A CN01100405 A CN 01100405A CN 1313114 A CN1313114 A CN 1313114A
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Abstract
A Chinese patent medicine for treating female Chimacteric syndrome is prepared from lucid ligustrum fruit, epimedium, red sage root, amber, vinegared cyperus tuber and parched jujube kernel through grinding the last three, decocting others to obtain concentrated liquid, mixing them together, adding additive, baking and loading in capsules. It has high curative effect.
Description
The present invention relates to a kind of medicine for the treatment of female dimacteric syndrome, is the Chinese medicine composition that is used for the treatment of female dimacteric syndrome specifically.
Climacteric is human endemism.Because time of senescing of male gonad is later, it is lighter symptom to occur, thus climacteric boundary not fairly obvious yet.The Women world has been generally acknowledged from beginning in 41 years old, has been lasted 15-20.35-65 year is expanded as at the American Studies center.Climacteric generally is divided into three periods: (1) premenopause, preceding 2～5 years of amenorrhea, average about 4 years; (2) menopause: continue amenorrhea 1 year; (3) postmenopause: menopause is about 15 years (be menopause to ovary endocrine function complete obiteration period, that is the stage before entering the geratic period), climacteric claimed again.Approximately menoxenia can take place in the climacteric women of 70-90%, and the different autonomic nervous dysfunction of companion's degree is main symptom, and wherein women's symptom of 10-30% is heavier, has reduced quality of life, needs treatment.The traditional Chinese medical science thinks that all diseases are because the kidney qi degradation dashes and appoints loss, and the damage of essence blood stasis causes imbalance of YIN and YANG before and after the postmenopausal women, due to the function disorder.
The method of western medical treatment female dimacteric syndrome mainly is an estrogen replacement therapy at present, and commonly used is nilestriol, but such medicine taboo is more, and side reaction is also many, and is difficult to reach the long-term treatment effect.Traditional Chinese medical science aspect does not have the specific treatment medicine as yet yet.
Therefore the purpose of this invention is to provide a kind of medicine of effective treatment female dimacteric syndrome, is the Chinese medicine complex specifically.It is more than 95% to the total effective rate of female dimacteric syndrome.
Medicine of the present invention is made up of by following weight portion proportioning following traditional Chinese medicines:
Ripe Fructus Ligustri Lucidi 15-30 Herba Epimedii 15-30 Radix Cyathulae 10-20
Radix Salviae Miltiorrhizae 10-20 succinum 5-12 Semen Ziziphi Spinosae (parched) 10-30
Herba Ecliptae 10-30 Rhizoma Cyperi (processed with vinegar) 5-15 Caulis Polygoni Multiflori 10-30
Ganoderma lucidum seu Japonicum 10-20
Each component optimum weight part proportioning is:
Who Fructus Ligustri Lucidi 20 Herba Epimedii 22 Radix Cyathulaes 15
Radix Salviae Miltiorrhizae 15 succinums 8 Semen Ziziphi Spinosae (parched)s 20
Herba Ecliptae 18 Rhizoma Cyperi (processed with vinegar) 10 Caulis Polygoni Multiflori 20
Ganoderma lucidum seu Japonicum 10
This pharmaceutical preparation is as follows:
With the said medicine letter sorting, clean, with the Rhizoma Cyperi infusion, per 5 kilograms of Rhizoma Cyperis add in the Rhizoma Cyperi and mix thoroughly with 1 kilogram of vinegar, and moistening is to blotting vinegar, and airing is standby.Semen Ziziphi Spinosae is cleaned, removed impurity and put into pot, fry to the little intensification of color with slow fire is little, taking-up cools.With the independent porphyrize of succinum, sieve, again with Rhizoma Cyperi, Semen Ziziphi Spinosae mixing porphyrize, cross No. 6 sieves and succinum mixing, pack into and stock usefulness.All the other medicines mix by the budget amount puts into steamer, add 15 times of amounts of water, steaming and decocting is extracted three times then, each 1.5 or 2 hours, is condensed into the gruel sample, in the storage that injection is got ready, with the medicated powder of getting ready, add mixing in the concentrated solution earlier, add an amount of adjuvant again, granulate and dry in the sterilization back, promptly encapsulated.Perhaps make as stated above in the bag of packing into behind the granule, make dissolved granule, every pouch 2 grams.As fry in shallow oil soup, and succinum consumption 1.5-6 gram, every auxiliary medicine decocts 2 times, sub-service sooner or later, succinum divides 2 times with the decoction clothes down.
Female dimacteric syndrome belongs to all diseases in traditional Chinese medical science menopause front and back.Its pathogenesis is the kidney qi degradation, deficiency of kidney-essence, and the imbalance between YIN and YANG of kidney, and cause internal organs pathological changes such as the heart, liver, spleen, thus make primary disease complicated and diversified clinical manifestation occur.The kidney qi degradation loses viscera, meridians, organizes moistening of QI and blood to support and warm, and QI and blood is also disorderly day by day because of the kidney qi degradation, and the amount of blood, color, therefore flow also changes, and stasis becomes the stasis of blood, thereby forms the pathological change of simulataneous insufficiency and excessive.Cool in nature, the sweet in the mouth of Fructus Ligustri Lucidi has the YIN nourishing invigorating the liver and kidney, the clearing away heat to improve acuity of vision effect; Herba Epimedii is warm in nature, acrid-sweet flavor, and it is warm in nature and not dry, and it imitate to be mended and not high, supporing yang and impairment of YIN not; Herba Epimedii, Fructus Ligustri Lucidi are monarch drug altogether, and cool temperature is made mutually, and negative and positive complement each other with mending, no matter be the deficiency of YIN or yang deficiency all available it.The Radix Salviae Miltiorrhizae cooling blood and removing stasis, tranquilizing by nourishing the heart; The Radix Achyranthis Bidentatae blood circulation promoting and blood stasis dispelling, invigorating the liver and kidney; The succinum promoting blood circulation to remove blood stasis, the arresting convulsion of calming the nerves, three flavors are ministerial drug altogether; Semen Ziziphi Spinosae tranquilizing by nourishing the heart arresting sweating; Herba Ecliptae enriching yin and nourishing kidney removing heat from blood, calmness is allayed excitement; Ganoderma lucidum seu Japonicum benefit vital essence, calms the nerves that it is good to imitate at bone and muscle strengthening; The Rhizoma Cyperi bar reaches irritability, the resolving depression regulating menstruation, and hypnosis is analgesic; Caulis Polygoni Multiflori nourishing blood to tranquillize the mind collateral dredging, the five tastes are adjuvant drug altogether, monarch's two ministers three assistants five, and prescription is rigorous, all medicine 5 usefulness, tonifying kidney-yin helps kidney yang, beneficial vital essence, bone and muscle strengthening, Disperse hepatic depression, blood stasis can be dispelled, hemorrhage ending, tranquilizing by nourishing the heart, the QI and blood people having the same aspiration and interest, treating both the principal and the secondary aspects of a disease at the same time is so clinical effectiveness is remarkable.
Modern medicine proves, the Women hormonal change is with ovarian function decline, hypothalamus one hypophysis one gonad axis due to the estrogen decrease change into key link.Scientific research is found, on the tissue at each more than 400 position of women's whole body and the cell membrane of organ estrogen receptor is arranged, when estrogen decrease, these tissues and organ will be found the variation in degeneration or the metabolism, it is uneven to cause climacteric women to occur in multisystems such as spirit, psychology, neuroendocrines, and then the symptom of a series of neuroendocrine imbalances occurs.Modern pharmacology studies have shown that: Fructus Ligustri Lucidi, Herba Epimedii, Radix Achyranthis Bidentatae, Radix Salviae Miltiorrhizae, Rhizoma Cyperi etc. have estrogen-like effects, and endocrine is had regulating action.Can strengthen the function of hypothalamic pituitary gonadal axis, but not influence normal endocrine.Estradiol is arranged in the Fructus Ligustri Lucidi, testosterone is arranged again, endocrine is had dual regulation.Polysaccharide in the Herba Epimedii can improve the synthetic ratio of DNA (deoxyribonucleic acid), obviously improves the symptom of the yang deficiency or the deficiency of YIN.The Herba Epimedii extracting solution can make calcified bone form to be increased, but prevention of osteoporosis, and can improve the reactivity of hypophysis to lutropin, and obviously increase antepituitary, ovary and uterus weight, improve ovary chorionic-gonadotropin hormone/interstitialcellstimulating hormone (ICSH) receptor-specific adhesion.Fructus Ligustri Lucidi, Herba Epimedii and blood pressure lowering, heart tonifying, anticoagulant arranged, protect the liver, blood sugar lowering, blood fat reducing, defying age and cerebral protection.
Wherein pharmaceutical composition of the present invention being made common pill, powder, oral liquid, tablet etc. also belongs in the category of the present invention.
1, clinical data
138 routine patients are the married woman, age 40-62 year, wherein 41-51 year 112 examples, 26 examples more than 55 years old, cardinal symptom: warm sweating, emotional lability 56 examples, insomnia is dizzy, menoxenia 102 examples, higher person's 29 examples of companion's blood pressure.
2, clinical symptoms: common sympton has: (1) menoxenia, menostaxis reduce not to the utmost or through amount until amenorrhea; (2) neck flush, hectic fever, systolic pressure raise, and fluctuation is obviously, and cardiopalmus can appear in part patient, chest sense of oppression, out of breath, and ECG ST section moves down; (3) abnormal emotion-thought is as worried, depressed, insomnia, dizzy, emotional; (4) vagina is done, is itched and burning sensation; (5) climacteric osteoporosis lumbago and backache, cervical spondylosis and the spinal canal stenosis etc. that cause; (6) other can show as weak, obesity etc.
3, Therapeutic Method
This group case all adopts has invigorating kidney, promoting blood circulation, the side's medicine woman Shu Xin capsule of the present invention and the decoction administration of the function of calming the nerves.Main component is that extractions such as Fructus Ligustri Lucidi, Herba Epimedii, Herba Ecliptae, Rhizoma Cyperi (processed with vinegar), Radix Salviae Miltiorrhizae, Semen Ziziphi Spinosae (parched), Caulis Polygoni Multiflori, succinum, Radix Achyranthis Bidentatae, Ganoderma lucidum seu Japonicum concentrate, and makes the granule capsule, every 0.3 gram.
Usage and dosage: each 4 (being equivalent to crude drug 3g), every day three times, as usefulness decoction pair every day one, sub-service sooner or later, six weeks were a course of treatment.
4, criterion of therapeutical effect and therapeutic effect
The criterion of therapeutical effect produce effects: clinical symptom disappearance, observe 2 months not recidivists; Effectively: clinical symptoms partly disappears or all disappears and the recidivist; Invalid: clinical symptoms does not have improvement.
Therapeutic effect: this organizes 138 examples, treat 1 the course of treatment produce effects 113 examples, effective 19 examples, invalid 6 examples, total effective rate is 97%.
5, medical record for example
Week so-and-so, the woman, 47 years old, the cadre, main suit's menoxenia 2 years, the beginning menostaxis not to the utmost, back infrequent menstruation, amenorrhea is 3 months, the companion has a sleepless night, cardiopalmus is weak, warms sweating, can not work and manage household affairs.Seeking medical advice in many places, all is diagnosed as climacteric syndrome, but because of its allergic constitution, take Western medicine and often cause allergy, treatment is intermittent, and first quarter moon is worried excessively before examining, and lies awake all night, the state of an illness increases the weight of, irritated irritability, sensation of oppression over the chest with shortness of breath, lumbago, talalgia, dark red, the few tongue of tongue, stringy and thready pulse are accompanied in moving then cardiopalmus, dizziness, sweating, are diagnosed as climacteric syndrome, recuperated under medical treatment for 1 course of treatment with woman Shu Xin capsule of the present invention, the elimination of all diseases is resumed work.
6, discuss
Female dimacteric syndrome belongs to all diseases in traditional Chinese medical science menopause front and back.Its pathogenesis is the kidney qi degradation, deficiency of kidney-essence, and the imbalance between YIN and YANG of kidney, and cause internal organs pathological changes such as the heart, liver, spleen, thus make primary disease complicated and diversified clinical manifestation occur.The kidney qi degradation loses viscera, meridians, organizes moistening of QI and blood to support and warm, and QI and blood is also disorderly day by day because of the kidney qi degradation, and the amount of blood, color, therefore flow also changes, and stasis becomes the stasis of blood, thereby forms the pathological change of simulataneous insufficiency and excessive.On the physiology, heart kidney regulation between water and fire, the Liver and kidney yi and Kui are derived from the same origin, deficiency of kidney yin can cause corresponding physiological change.The not warm soil of kidney yang deficiency, fire can cause the deficiency of spleen-YANG and kidneyYANG disease again.In a word, Woman climacteric, suffering from a deficiency of the kidney is to cause a disease originally, women's characteristics are " YIN often being in shortage, YANG often being in excess ", and are in the majority with the deficiency of the kidney yin person again.No matter deficiency of the kidney yin or insufficiency of kidney-YANG, but equal hyperamization stasis of bloods.The origin cause of formation of blood stasis can be summarized as (1) blood stasis due to qi deficiency, and the kidney being the origin of congenital constitution, the source of spermatogenesis, and the vital essence deficiency, then blood fortune is unable, and the hyperamization stasis of blood; (2) kidney master water, insufficiency of kidney-YANG then evaporates incapability, and water can not activating QI, and then the expectorant stasis of blood stops holding mutual knot; (3) deficiency of YIN is to the stasis of blood, and the deficiency of YIN consumes impairment of body fluid liquid, and body fluid deficiency is insufficiency of blood then, and the blood mistake is moistened foster, and blood stasis viscous is then moved the slow hyperamization liquid stasis of blood and stagnated; (4) stagnation of QI causes the stasis of blood, how because of feelings will is uncomfortable, and depression of liver-QI, ascending or descending movement of vital Qi is lacked of proper care and is caused qi depression to blood stasis; (5) prolonged illness causes the stasis of blood, climacteric syndrome, and the disease multiterminal, febrile disease is touching, and the traditional Chinese medical science is called it " pathogen usually intruding into collateral in protracted disease, prolonged illness must the stasis of blood ".If when effecting a permanent cure, take the circumstances into consideration to add and use the nourshing blood and promoting blood circulation medicine, can improve curative effect preferably.
Embodiment 1
10 kilograms of 15 kilograms of Radix Cyathulaes of 15 kilograms of Herba Epimedii of ripe Fructus Ligustri Lucidi
10 kilograms of 5 kilograms of Semen Ziziphi Spinosae (parched)s of 10 kilograms of succinums of Radix Salviae Miltiorrhizae
10 kilograms of 5 kilograms of Caulis Polygoni Multiflori of 10 kilograms of Rhizoma Cyperi (processed with vinegar) of Herba Ecliptae
10 kilograms of Ganoderma lucidum seu Japonicumes
With the said medicine letter sorting, clean, with the Rhizoma Cyperi infusion, per 5 kilograms of Rhizoma Cyperis add in the Rhizoma Cyperi and mix thoroughly with 1 kilogram of vinegar, and moistening is to blotting vinegar, and airing is standby.Semen Ziziphi Spinosae is cleaned, removed impurity and put into pot, fry to the little intensification of color with slow fire is little, taking-up cools.With the independent porphyrize of succinum, sieve, again with Rhizoma Cyperi, Semen Ziziphi Spinosae mixing porphyrize, cross No. 6 sieves and succinum mixing, pack into and stock usefulness.All the other medicines mix by the budget amount puts into steamer, add 15 times of amounts of water, steaming and decocting is extracted three times then, each 1.5 or 2 hours, is condensed into the gruel sample, in the storage that injection is got ready, with the medicated powder of getting ready, add mixing in the concentrated solution earlier, add an amount of adjuvant again, granulate and dry in the sterilization back, promptly encapsulated.Perhaps make as stated above in the bag of packing into behind the granule, make dissolved granule, every pouch 2 grams.As fry in shallow oil soup, and succinum consumption 1.5-6 gram, every auxiliary medicine decocts 2 times, sub-service sooner or later, succinum divides 2 times with the decoction clothes down.
Embodiment 2
20 kilograms of 30 kilograms of Radix Cyathulaes of 30 kilograms of Herba Epimedii of ripe Fructus Ligustri Lucidi
30 kilograms of 12 kilograms of Semen Ziziphi Spinosae (parched)s of 20 kilograms of succinums of Radix Salviae Miltiorrhizae
30 kilograms of 15 kilograms of Caulis Polygoni Multiflori of 30 kilograms of Rhizoma Cyperi (processed with vinegar) of Herba Ecliptae
20 kilograms of Ganoderma lucidum seu Japonicumes
Method for making is with embodiment 1.
Embodiment 3
15 kilograms of 22 kilograms of Radix Cyathulaes of 20 kilograms of Herba Epimedii of who Fructus Ligustri Lucidi
20 kilograms of 8 kilograms of Semen Ziziphi Spinosae (parched)s of 15 kilograms of succinums of Radix Salviae Miltiorrhizae
20 kilograms of 10 kilograms of Caulis Polygoni Multiflori of 18 kilograms of Rhizoma Cyperi (processed with vinegar) of Herba Ecliptae
10 kilograms of Ganoderma lucidum seu Japonicumes
Method for making is with embodiment 1.
Claims (5)
1, a kind of Chinese medicine composition for the treatment of female dimacteric syndrome is characterized in that it is made up of by following weight portion proportioning following Chinese medicine:
Ripe Fructus Ligustri Lucidi 15-30 Herba Epimedii 15-30 Radix Cyathulae 10-20
Radix Salviae Miltiorrhizae 10-20 succinum 5-12 Semen Ziziphi Spinosae (parched) 10-30
Herba Ecliptae 10-30 Rhizoma Cyperi (processed with vinegar) 5-15 Caulis Polygoni Multiflori 10-30
Ganoderma lucidum seu Japonicum 10-20
2, the Chinese medicine composition of claim 1 is characterized in that the weight portion proportioning of above-mentioned Chinese medicine is:
Who Fructus Ligustri Lucidi 20 Herba Epimedii 22 Radix Cyathulaes 15
Radix Salviae Miltiorrhizae 15 succinums 8 Semen Ziziphi Spinosae (parched)s 20
Herba Ecliptae 18 Rhizoma Cyperi (processed with vinegar) 10 Caulis Polygoni Multiflori 20
Ganoderma lucidum seu Japonicum 10
3, claim 1 or 2 Chinese medicine composition is characterized in that its preparation method is as follows:
With the said medicine letter sorting, clean, with the Rhizoma Cyperi infusion, per 5 kilograms of Rhizoma Cyperis add in the Rhizoma Cyperi and mix thoroughly with 1 kilogram of vinegar, and moistening is to blotting vinegar, and airing is standby.Semen Ziziphi Spinosae is cleaned, removed impurity and put into pot, fry to the little intensification of color with slow fire is little, taking-up cools.With the independent porphyrize of succinum, sieve, again with Rhizoma Cyperi, Semen Ziziphi Spinosae mixing porphyrize, cross No. 6 sieves and succinum mixing, pack into and stock usefulness.All the other medicines mix by the budget amount puts into steamer, add 15 times of amounts of water, steaming and decocting is extracted three times then, each 1.5 or 2 hours, is condensed into the gruel sample, in the storage that injection is got ready, with the medicated powder of getting ready, add mixing in the concentrated solution earlier, add an amount of adjuvant again, granulate and dry in the sterilization back, promptly encapsulated.Perhaps make as stated above in the bag of packing into behind the granule, make dissolved granule, every pouch 2 grams.As fry in shallow oil soup, and succinum consumption 1.5-6 gram, every auxiliary medicine decocts 2 times, sub-service sooner or later, succinum divides 2 times with the decoction clothes down.
4, claim 1 or 2 Chinese medicine composition is characterized in that it is a capsule preparations.
5, claim 1 or 2 Chinese medicine composition is characterized in that it is a granular preparation.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB011004053A CN1150920C (en) | 2001-01-10 | 2001-01-10 | Medicine for treating female dimacteric syndrome and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB011004053A CN1150920C (en) | 2001-01-10 | 2001-01-10 | Medicine for treating female dimacteric syndrome and its preparing process |
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| CN1313114A true CN1313114A (en) | 2001-09-19 |
| CN1150920C CN1150920C (en) | 2004-05-26 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102784376A (en) * | 2012-08-03 | 2012-11-21 | 李娜 | Preparation method of traditional Chinese medicine for treating anorexia type acute glomerulonephritis |
| CN103933477A (en) * | 2014-04-21 | 2014-07-23 | 青岛市第三人民医院 | Chinese medicinal preparation for treating female climacteric syndrome |
| CN105250754A (en) * | 2015-10-19 | 2016-01-20 | 黄淮学院 | Traditional Chinese medicine composition for relieving menopausal symptoms and application of traditional Chinese medicine composition |
-
2001
- 2001-01-10 CN CNB011004053A patent/CN1150920C/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102784376A (en) * | 2012-08-03 | 2012-11-21 | 李娜 | Preparation method of traditional Chinese medicine for treating anorexia type acute glomerulonephritis |
| CN102784376B (en) * | 2012-08-03 | 2014-04-09 | 李娜 | Preparation method of traditional Chinese medicine for treating anorexia type acute glomerulonephritis |
| CN103933477A (en) * | 2014-04-21 | 2014-07-23 | 青岛市第三人民医院 | Chinese medicinal preparation for treating female climacteric syndrome |
| CN103933477B (en) * | 2014-04-21 | 2016-11-02 | 青岛市第三人民医院 | Chinese medicinal preparation for treating female climacteric syndrome |
| CN105250754A (en) * | 2015-10-19 | 2016-01-20 | 黄淮学院 | Traditional Chinese medicine composition for relieving menopausal symptoms and application of traditional Chinese medicine composition |
| CN105250754B (en) * | 2015-10-19 | 2019-02-22 | 黄淮学院 | It is a kind of alleviate menopause symptom Chinese medicine composition and its application |
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| Publication number | Publication date |
|---|---|
| CN1150920C (en) | 2004-05-26 |
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Granted publication date: 20040526 Termination date: 20100210 |