CN1895399A - Chinese-medicinal preparation for treating early diabetic retinopathy - Google Patents
Chinese-medicinal preparation for treating early diabetic retinopathy Download PDFInfo
- Publication number
- CN1895399A CN1895399A CN 200610087540 CN200610087540A CN1895399A CN 1895399 A CN1895399 A CN 1895399A CN 200610087540 CN200610087540 CN 200610087540 CN 200610087540 A CN200610087540 A CN 200610087540A CN 1895399 A CN1895399 A CN 1895399A
- Authority
- CN
- China
- Prior art keywords
- grams
- gram
- preparation
- chinese
- proportioning
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
A Chinese medicine for treating the early-phase diabetic retinosis (DR) is prepared from 5 Chinese-medicinal materials including astragalus root, lucid ligustrum fruit, motherwort, black plum, etc through decocting.
Description
The present invention relates to field of medicaments, the Chinese medicine preparation of the retinopathy that to be a kind of treatment caused by diabetes.
(Diabetes mellitus DM) is a kind of commonly encountered diseases, frequently-occurring disease to diabetes, shows that according to WHO global diabetics sum was about 1.35 hundred million in 1996, estimates will rise to 300,000,000 in 2025.(Diabeticretinopathy DR) is the severe complication of diabetes to diabetic renal papillary necrosis, and along with diabetic duration prolongs, the DR sickness rate increases year by year, and diabetic duration is that 63%, 30 year person reaches 95% greater than 16 years person DR sickness rate.The drug main of the early stage retinopathy of treatment will divide two big classes at present: the medicine and the etiotropic medicine that improve retinal microcirculation.The clinical medicine of having introduced to the market such as Doxium, Difrarel etc. all belong to the medicine that improves retinal microcirculation, and price is higher, uncertain therapeutic efficacy.Multiple medicine for the treatment of at the cause of disease, pathogenesis is still in the experimentation stage.Not obvious and the economics dictate because the DR early vision descends, most of patients is often ignored treatment.In case go to a doctor, pathological changes is to mid-term, even blood sugar control can not stop course of disease progress, so early prevention and treatment, for the generation of control DR, delay course of disease progress, most important to reduce sickness rate and blind rate.Since DR be diabetes with the passing of time due to, except that treatment eye pathological changes, also want blood sugar control, blood pressure, blood fat reducing improves patient's General Symptoms.Organic conception is adopted in Chinese traditional treatment, carries out determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs.For the pathogenesis of DR, we think that with the passing of time high sugar consume impairment of QI the moon in the blood, cause angiostenosis or obturation, eyes losing nutrition, blurring of vision.Then give birth in the deficiency-heat for a long time, decoct body fluid, the deficiency of vital energy can not help the blood operation, and deficiency of YIN sering is not smooth and hematogenous blockage causes and gives birth in the blood stasis, and escape of blood from meridians loses its normal manner, and is hemorrhage repeatedly and cause losing one's sight.Primary disease simulataneous insufficiency and excessive, cold and heat also sees, and is clinical in deficiency of both QI and YIN, and stasis of blood resistance order network syndrome is seen in that DR more in early days more.
Aim of the present invention is that diabetes are of a specified duration at the high incidence of the diabetic renal papillary necrosis of modern society, has both considered the one side of its deficiency syndrome in the treatment, considers the one side of the excess syndrome of eye card again.Prolonged illness consumption impairment of QI the moon, so how empty, common weak, tired its disease is, dizziness and tinnitus, insomnia and dreamful sleep; But because of its easy sentimentality again, so many again stasis of bloods hinder the syndrome of order network, the time and blurred vision is looked fatigue of a specified duration, the optical fundus is seen hemorrhage, microangioma etc.So treatment should be dialectical combines with differential diagnosis of diseases, macroscopic view is dialectical to combine with retinal hemorrhage, edema, the microcosmic syndrome differentiation that oozes out, from integral body sight, treating both the principal and secondary aspects of a disease.
For realizing above-mentioned aim, the present invention has developed a kind of Chinese medicine preparation specially, and it is to form with the Radix Astragali, Fructus Ligustri Lucidi, Herba Leonuri, Fructus Mume, Rhizoma Coptidis, Cortex Cinnamomi, Flos Buddlejae that its prescription is formed.
But this medicament supplementing QI and nourishing YIN, promoting blood circulation to remove obstruction in the collateral obviously improves visual function.Medicinal Astragalis is that monarch drug stagnates inducing diuresis to remove edema with the QI invigorating row; With Fructus Ligustri Lucidi, Herba Leonuri, Fructus Mume is ministerial drug, nourishing the liver and kidney, activating blood and promoting diuresis, clearing away heat to improve acuity of vision; Rhizoma Coptidis, Cortex Cinnamomi restoring normal coordination between the heart and kidney, making regulation between water and fire is assistant; The messenger drug Flos Buddlejae has clearing away liver-fire, tonifying liver void, the effect of improve visual and auditory acuity.It is greasy that this medicine had both avoided the agent of nourishing the liver and kidney in the past too to grow, and again on this basis, uses the medicine with clearind deficient heat and clearing away liver-fire, more paying attention to the irritability accent than its medicine reaches, the agent of cold and heat and usefulness are devoted to the balance of function and the coordinative role between the eye functional rehabilitation, and pathological changes is recovered.The clinical pharmacology experiment shows: medicines such as the Radix Astragali, Fructus Ligustri Lucidi, Fructus Mume can strengthen people's immunity, blood sugar regulation, the effect of protection vascular system; Rhizoma Coptidis, Cortex Cinnamomi, Herba Leonuri have antibiotic; blood vessel dilating, effects such as blood circulation promoting, Flos Buddlejae can reduce the permeability of blood vessel.
The inventor is based on theory of integrated Chinese and western medicine, adopt behind the Chinese drug-treated group cost preparation decocting oral, every day potion.Its each each components contents of agent material medicine (weight) scope is: the Radix Astragali 30 grams-60 grams, Fructus Ligustri Lucidi 9 grams-15 grams, Herba Leonuri 9 grams-30 grams, Fructus Mume 3 grams-10 grams, Rhizoma Coptidis 2 grams-9 grams, Cortex Cinnamomi 2 grams-5 grams, Flos Buddlejae 3 grams-9 grams, according to patient's concrete condition, in described content range, take the circumstances into consideration to adjust for each drug component.
The optimum ratio of each drug component is in the preparation of the present invention: the Radix Astragali 40 grams, Fructus Ligustri Lucidi 9 grams, Herba Leonuri 15 grams, Fructus Mume 10 grams, Rhizoma Coptidis 9 grams, Cortex Cinnamomi 2 grams, Flos Buddlejae 9 grams.
In addition, the proportioning of each drug component of preparation of the present invention also is preferably: the Radix Astragali 30 grams, Fructus Ligustri Lucidi 15 grams, Herba Leonuri 15 grams, Fructus Mume 9 grams, Rhizoma Coptidis 6 grams, Cortex Cinnamomi 1 gram, Flos Buddlejae 6 grams.
This medicaments preparation method: 1. get seven doses of the interior medicines in proportion of above-mentioned content range.2. with cleaning cold water soak 30 minutes.3. put into boiling machine, add 2500 milliliters and soak water, decocted 40 minutes, mechanical presses goes out medicine juice.4. in 14 sealed plastic bags of packing, 175 milliliters every bag.
This Chinese medicine preparation medicinal effects is remarkable, has no side effect, and taking convenience, preparation technology is simple, is the Chinese medicine preparation of ideal treatment early diabetic retinopathy, can supply wide clinical application.
Toxicity test research of the present invention is as follows:
One. acute toxicity testing
1. half causes death and tests:
Select healthy 20 rat (male and female half and half), body weight 250 grams-400 grams are got this preparation 5 and restrain/only are dissolved in water, irritate stomach to rat, once feeding.Observed 7 days after the administration, do not find the variation of digestive system, respiratory system, nervous system aspect, the rat activity is as usual, and none example is dead.
2. maximum tolerance determination:
Get 20 of white mice (male and female half and half), body weight 25-40 gram by 8 gram/kg body weight, this preparation of lumbar injection medicinal liquid, once injects, and observes 20 white mice health continuously 7 days.The test dosage is equivalent to 40 times of clinical application.
Two, long term toxicity test:
Select healthy 20 rat (male and female half and half), body weight 250 grams-400 grams are by 1 gram/kg body weight, irritate stomach with this preparation, be administered once every day, successive administration 90 days, do not observe poison, side reaction, rat on the feed, each side such as movable, hair color and body weight are all normal.
Embodiment 1:
This medicaments preparation method: 1. get seven doses of the interior medicines in proportion of above-mentioned content range.2. with cleaning cold water soak 30 minutes.3. put into boiling machine, add 2500 milliliters and soak water, decocted 40 minutes, mechanical presses goes out medicine juice.4. in 14 sealed plastic bags of packing, 175 milliliters every bag.
Embodiment 2:
Press the optimum ratio of each material medicine content (weight) of this medicament: the Radix Astragali 30 grams, Fructus Ligustri Lucidi 15 grams, Herba Leonuri 15 grams, Fructus Mume 9 grams, Rhizoma Coptidis 6 restrains, Cortex Cinnamomi 1 gram, Flos Buddlejae 6 grams are made this preparation with the preparation method of embodiment 1.
Take this preparation in the patients with diabetic retinopathy in 40-70 year for 30 ages, each 175 milliliters, every day, secondary was a course of treatment around the continuous oral.Take 2-3 the course of treatment, clinical effectiveness is good, and effective percentage and satisfaction rate are more than 95%.
Wherein a typical case is: turn round and look at so-and-so, and the woman, 60 years old, told diabetes 10 years, the eyes blurred vision has an eyesight test: right eye 0.4, left eye 0.5, the optical fundus microangioma, visual field sensitivity descends, diagnosis DRI phase, cards such as the whole body companion is weak, the soreness of waist, constipation.Take the preparation that this optimum ratio prescription is made, each 175 milliliters, every day secondary, continuous oral is after eight weeks.General Symptoms is alleviated, and stool is normal, and binocular vision brings up to 0.8.
Claims (5)
1. the Chinese medicine preparation that becomes of a treatment of diabetic retinopathy.
2. preparation according to claim 1 contains the Chinese medicinal components of making by following proportioning: Radix Astragali 30-60 gram, Fructus Ligustri Lucidi 9-15 gram, Herba Leonuri 9-30 gram, Fructus Mume 3-10 gram, Rhizoma Coptidis 2-9 gram, Cortex Cinnamomi 2-5 gram, Flos Buddlejae 3-9 gram.
3. preparation according to claim 1, wherein the proportioning of each Chinese medicinal components is: the Radix Astragali 40 grams, Fructus Ligustri Lucidi 9 grams, Herba Leonuri 15 grams, Fructus Mume 10 grams, Rhizoma Coptidis 9 grams, Cortex Cinnamomi 2 grams, Flos Buddlejae 9 grams.
4. preparation according to claim 1, wherein the proportioning of each Chinese medicinal components is: the Radix Astragali 30 grams, Fructus Ligustri Lucidi 15 grams, Herba Leonuri 15 grams, Fructus Mume 9 grams, Rhizoma Coptidis 6 grams, Cortex Cinnamomi 1 gram, Flos Buddlejae 6 grams.
5. the preparation method of any one described preparation of claim 2-4 is characterized in that: seven doses of the each component medicines of (1) corresponding proportioning; (2) with cleaning cold water soak 30 minutes; (3) put into boiling machine, add 2500 milliliters and soak water, decocted 40 minutes, mechanical presses goes out medicine juice; (4) in 14 sealed plastic bags of packing, 175 milliliters every bag.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100875403A CN100540022C (en) | 2006-06-14 | 2006-06-14 | A kind of Chinese medicine preparation for the treatment of early diabetic retinopathy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100875403A CN100540022C (en) | 2006-06-14 | 2006-06-14 | A kind of Chinese medicine preparation for the treatment of early diabetic retinopathy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1895399A true CN1895399A (en) | 2007-01-17 |
| CN100540022C CN100540022C (en) | 2009-09-16 |
Family
ID=37608137
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006100875403A Active CN100540022C (en) | 2006-06-14 | 2006-06-14 | A kind of Chinese medicine preparation for the treatment of early diabetic retinopathy |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100540022C (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009015515A1 (en) * | 2007-07-31 | 2009-02-05 | Xiyuan Hospital, China Academy Of Chinese Medical Sciences | A pharmaceutical composition for regulating blood sugar level and blood fat level, process for preparation and use thereof |
| CN104161850A (en) * | 2014-07-25 | 2014-11-26 | 北京汉典制药有限公司 | Preparation method of Chinese herbal extract, prepared Chinese herbal extract and application |
| CN104161848A (en) * | 2014-07-25 | 2014-11-26 | 北京汉典制药有限公司 | Preparation method of Chinese herbal extract, prepared Chinese herbal extract and application |
| CN104161849A (en) * | 2014-07-25 | 2014-11-26 | 北京汉典制药有限公司 | Traditional Chinese medicinal tablet for curing diabetic retinopathy and application thereof |
| CN104161847A (en) * | 2014-07-25 | 2014-11-26 | 北京汉典制药有限公司 | Quality detection method of traditional Chinese medicinal composition for curing diabetic retinopathy |
| CN104173504A (en) * | 2014-07-25 | 2014-12-03 | 北京汉典制药有限公司 | Traditional Chinese medicine capsule for treating diabetic retinopathy and application of traditional Chinese medicine capsule for treating diabetic retinopathy |
| CN104173503A (en) * | 2014-07-25 | 2014-12-03 | 北京汉典制药有限公司 | Preparation method of traditional Chinese medicine granules, traditional Chinese medicine granules prepared by same and use of traditional Chinese medicine granules |
| CN104173505A (en) * | 2014-07-25 | 2014-12-03 | 北京汉典制药有限公司 | Compound traditional Chinese medicine extract, as well as preparation method and application thereof |
| CN104173506A (en) * | 2014-07-25 | 2014-12-03 | 北京汉典制药有限公司 | Traditional Chinese medicine extract, as well as preparation method and application thereof |
| CN104189146A (en) * | 2014-07-25 | 2014-12-10 | 北京汉典制药有限公司 | Concentrated traditional Chinese medicine water pill and application thereof |
-
2006
- 2006-06-14 CN CNB2006100875403A patent/CN100540022C/en active Active
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009015515A1 (en) * | 2007-07-31 | 2009-02-05 | Xiyuan Hospital, China Academy Of Chinese Medical Sciences | A pharmaceutical composition for regulating blood sugar level and blood fat level, process for preparation and use thereof |
| AU2007357043B2 (en) * | 2007-07-31 | 2010-11-11 | Xiyuan Hospital, China Academy Of Chinese Medical Sciences | Pharmaceutical composition for regulating blood sugar and fat, preparation and use thereof |
| CN104161850A (en) * | 2014-07-25 | 2014-11-26 | 北京汉典制药有限公司 | Preparation method of Chinese herbal extract, prepared Chinese herbal extract and application |
| CN104161848A (en) * | 2014-07-25 | 2014-11-26 | 北京汉典制药有限公司 | Preparation method of Chinese herbal extract, prepared Chinese herbal extract and application |
| CN104161849A (en) * | 2014-07-25 | 2014-11-26 | 北京汉典制药有限公司 | Traditional Chinese medicinal tablet for curing diabetic retinopathy and application thereof |
| CN104161847A (en) * | 2014-07-25 | 2014-11-26 | 北京汉典制药有限公司 | Quality detection method of traditional Chinese medicinal composition for curing diabetic retinopathy |
| CN104173504A (en) * | 2014-07-25 | 2014-12-03 | 北京汉典制药有限公司 | Traditional Chinese medicine capsule for treating diabetic retinopathy and application of traditional Chinese medicine capsule for treating diabetic retinopathy |
| CN104173503A (en) * | 2014-07-25 | 2014-12-03 | 北京汉典制药有限公司 | Preparation method of traditional Chinese medicine granules, traditional Chinese medicine granules prepared by same and use of traditional Chinese medicine granules |
| CN104173505A (en) * | 2014-07-25 | 2014-12-03 | 北京汉典制药有限公司 | Compound traditional Chinese medicine extract, as well as preparation method and application thereof |
| CN104173506A (en) * | 2014-07-25 | 2014-12-03 | 北京汉典制药有限公司 | Traditional Chinese medicine extract, as well as preparation method and application thereof |
| CN104189146A (en) * | 2014-07-25 | 2014-12-10 | 北京汉典制药有限公司 | Concentrated traditional Chinese medicine water pill and application thereof |
| CN104161847B (en) * | 2014-07-25 | 2016-08-24 | 北京汉典制药有限公司 | A kind of quality determining method of the Chinese medicine composition treating diabetic retinopathy |
| CN104173505B (en) * | 2014-07-25 | 2016-09-21 | 北京汉典制药有限公司 | The preparation method of a kind of Chinese medicinal compound extract and the Chinese medicinal compound extract of preparation thereof and purposes |
| CN104173504B (en) * | 2014-07-25 | 2016-09-21 | 北京汉典制药有限公司 | A kind of Chinese medicine capsules treating diabetic retinopathy and application thereof |
| CN104173506B (en) * | 2014-07-25 | 2016-10-05 | 北京汉典制药有限公司 | The Chinese medical extract of the preparation method of a kind of Chinese medical extract and preparation thereof and purposes |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100540022C (en) | 2009-09-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100540022C (en) | A kind of Chinese medicine preparation for the treatment of early diabetic retinopathy | |
| CN103550532B (en) | Traditional Chinese medicine (TCM) composition for treating palpitation | |
| CN102988750A (en) | TCM (Traditional Chinese medicine) composition for treating diabetes and preparation method thereof | |
| CN101940694B (en) | Medicament for regulating sub-health of human body | |
| CN103720857A (en) | Traditional Chinese medicinal preparation for treating fundus macular oedema lesion | |
| CN103341127A (en) | Traditional Chinese medicine for treating uremia along with hematodialysis and preparation method | |
| CN101229345B (en) | Qi-replenishing and blood-enriching medicine | |
| CN103550688B (en) | A kind of Chinese medicine composition for the treatment of cardiopalmus | |
| CN105596735A (en) | Medicine composition for treating diabetes mellitus | |
| CN103169882A (en) | Traditional Chinese medicine composition for treating diabetes | |
| CN1169546C (en) | Chinese medicine for treating hypotension | |
| CN100581581C (en) | Technique for preparing Chinese traditional medicine and pills for clearing away heart-fire, dispersing phlegm, tranquilizing the mind, and reducing blood pressure | |
| CN101579455B (en) | Traditional Chinese medicine preparation for treating consumptive disease | |
| CN105106758A (en) | Traditional Chinese medicine composition for treating phlegm and blood stasis type dizziness | |
| CN1123350C (en) | Chinese patent medicine (Tangweiping) for treating eyeground affection of diabetes | |
| CN100566740C (en) | A kind of Chinese herb medicine of preventing and treating myopia | |
| CN1022165C (en) | Preparation and process of oral medicinal liquid for recuperating blood vessels | |
| CN100339119C (en) | Traditional Chinese medicine prepns. for treating diabete | |
| CN102430016B (en) | Chinese medicinal composition for treating edema | |
| CN102416112B (en) | Chinese medicinal composition for treating diabetes | |
| CN106177585A (en) | A kind of prevention and the Chinese herbal and crude drugs preparations for the treatment of subhealth state | |
| CN101099803B (en) | Pill-tablet for effective fat-reducing and treating three-high (hyperglycemia, hypertension and hyperlipemia) | |
| CN1395946A (en) | Chinese medicine for relieving fatigue | |
| CN105168589A (en) | Eye-care traditional Chinese medicine gel preparation and preparation method thereof | |
| CN103479821B (en) | Chinese medicine composition of a kind of the kidney invigorating benefit blood and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: BEIJING HANDIAN PHARMACEUTICAL CO., LTD. Effective date: 20121113 Owner name: BEIJING RED SUN PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: GAO JIANSHENG Effective date: 20121113 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 100040 SHIJINGSHAN, BEIJING TO: 100020 CHAOYANG, BEIJING |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20121113 Address after: 100020 Beijing city Chaoyang District Chaowai Street No. 12 B Building No. 1 room 2206 International Building quintiles Patentee after: Beijing Red Sun Pharmaceutical Co., Ltd. Patentee after: Beijing Handian Pharmaceutical Co., Ltd. Address before: 100040 Eye Hospital of Chinese Academy of traditional Chinese medicine, 33 Lu Gu Road, Shijingshan District, Beijing Patentee before: Gao Jiansheng |