CN1395946A - Chinese medicine for relieving fatigue - Google Patents

Abstract

A Chinese medicine in the form of oral liquid, instant powder, or capsule for treating exhaustion syndrome is prepared from 5 Chinese medicinal materials including ginseng, ganoderma, white peony root, etc.. Its advantages are high curative effect and no toxic by-effect.

Description

The pure Chinese medicinal preparation that treatment is tired

The present invention relates to field of medicaments, is a kind of tired pure Chinese medicinal preparation for the treatment of.

Tired morbidity secret is often ignored by people, and along with the social life work rhythm is accelerated, people's physical and psychological pressure also day by day increases, and causes sickness rate that ascendant trend is year by year arranged in recent years.In recent years, clinically research treatment more be chronic fatigue syndrome and sports fatigue.Chronic fatigue syndrome (Chronic fatigue syndrome, CFS) be a kind of be outstanding behaviours with the chronic fatigue, simultaneously with low grade fever, lymph node swells and ache, the syndrome of muscular soreness, neural mental symptom, crucial immunological abnormality and other non-specific manifestations.Sports fatigue promptly refer to by body movement itself caused " the organism physiology process can not continue its function on a specified level and/or can not keep predetermined exercise intensity " the phenomenon of body movement ability drop.Because of modern medicine does not still have definite final conclusion to the understanding of the aspects such as the cause of disease, essence and morbidity of CFS at present, simultaneously, the generation of sports fatigue, development mechanism are also very complicated, so clinically also lack effective Therapeutic Method.

The traditional Chinese medical science thinks that the tired cause of disease is overworked, comprises labour, a tax on one's mind and excess of sexual intercourse in ancient book more.With liver,spleen,kidney three is dirty substantial connection arranged." element is asked and lifted the pain opinion " carries: " overexertion leading to consumption of QI.The Lao Ze sweating of panting is inside and outsidely all got over, so QI consumed." Golden Mirror of Medicine: the argumentation of " internal injury forced labour impairment of the spleen gas ".The traditional Chinese medical science is thought, causes that the reason of CFS mainly contains: bother excessively, feelings will is not smooth, innate deficiency or lose in conditioning greatly after being ill etc.; And hard training, consumption energy consumption gas easily causes YANG QI deficiency and to cause limb soft weak, tired card, on the other hand, again because of in the motor process, sweating is more, and impairment of body fluid consumption liquid easily causes YIN-fluid being insufficient again, spleen closes muscle outward in addition, and muscle is fatigued, and spleen is earlier impaired, dysfunction of the spleen in transportation, and then cause damp and hot interior giving birth to, aster is old gradually long-pending, increase the weight of heat stagnation in the lining, thereby the performance of sports fatigue still there is the card of interior-heat caused by deficiency of YIN such as xerostomia, dry pharynx all the more.Chinese medicine prevention fatigue has significant advantage, and over past ten years, it is also day by day gradually many to grind the Chinese medicine relevant report of controlling fatigue syndrome and sports fatigue from clinical and experimental viewpoint, has embodied Chinese medicine and has cured the tired good prospect for the treatment of.

Clinical expert is controlled at the clinical card of fatigue respectively profound view, whenever control with stagnation of liver-QI with deficiency of the spleen, pattern of syndrome opinion such as suffer from a deficiency of the kidney, giving consideration to both the incidental and fundamental, add and subtract with disease, the treatment primary disease, and obtain certain curative effect, but it is unified as yet about the standard diagnostic criteria of CFS and sports fatigue to be limited to the traditional Chinese medical science, thus clinical card control grind to control and still owe accurate.

Aim of the present invention is increasing at people's its physical and mental burden under more and more fierce competitive environment of modern society, so should consider the one side of fatigue syndrome and sports fatigue deficiency syndrome in the treatment, also wanting has the one side of excess syndrome to it.The stagnation of QI is how uncomfortable by feelings will, and the liver failing to maintain the normal flow of QI causes, and disharmony between the liver and spleen can cause spleen insufficiency, the phlegm-damp cohesion, and visceral dysfunction, deficiency of qi and blood can cause QI and blood not transported, and give birth in the blood stasis, and blood stasis does not remove to hinder again new hemopoiesis, i.e. the apoplexy due to deficiency folder stasis of blood.As seen, deficiency syndrome are main diseases of most CFS and sports fatigue clinical patients, also often send out because of clinical manifestation is different to be the deficiency in origin and excess in superficiality card, or deficiency and excess hold assorted card under the arm, and the stagnation of QI, expectorant coagulate, blood stasis is the real performance of mark.Simultaneously, it is abnormal emotion-thought that very big factor is levied in tired comprehensive morbidity, with excessive thinking and anxiety direct relation is arranged, again because sports fatigue often with stress be relevant, so, be necessary to emphasize the physiological and pathological effect of " heart " in the tired pathogenic process.The fatigue disease position relates to the heart, liver,spleen,kidney more, and the pathogenesis master is stagnation of liver-QI with deficiency of the spleen, heart-liver blood deficiency, disarmony between the heart and kidney.Should pay attention in clinical dialectically combining with differential diagnosis of diseases, from integral body, treating both the principal and secondary aspects of a disease, invigorating middle warmer has thin.

For realizing above-mentioned aim, the present invention has developed a kind of pure Chinese medicinal preparation specially, and is used for clinical with capsule formulation.It is to form with Radix Ginseng, the Radix Astragali, Ganoderma, the Radix Paeoniae Alba, Radix Curcumae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati, Arillus Longan, Herba Epimedii, Herba Cistanches component that its prescription is formed.

But this medicament benefiting qi and supporting yang, accent tonifying liver spleen, restoring normal coordination between the heart and kidney.Ginseng for medicinal use, Ganoderma, the Radix Astragali be monarch with invigorate vital energy and yang, the kidney tonifying spleen invigorating; With the Radix Paeoniae Alba, Radix Curcumae, Radix Salviae Miltiorrhizae is ministerial drug, both nourishing blood to suppress the hyperactive liver, and the merit of SIWU TANG to the greatest extent again, adding Radix Curcumae can invigorate blood circulation by liver clearing and depression relieving in tonification; With Rhizoma Polygonati, Arillus Longan is adjuvant drug, and tonification is cloudy smart, restoring normal coordination between the heart and kidney; Messenger drug Herba Epimedii, Herba Cistanches warming and recuperating the spleen and kidney, the YIN nourishing relieving constipation.The grand effect of this efficacy of a drug is special, has both avoided high violent tonifying YANG, consumption impairment of YIN essence, again on the basis of tonification liver,spleen,kidney, more pay attention to liver controlling conveyance and dispersion, the effect that The heart controls mental activities, be devoted to the recovery and the effect between each internal organs of function and coordinate, the meridian qi and blood operation is unobstructed, and fatigue is cured.The clinical pharmacology experiment shows that Radix Ginseng is rich in B kind Saponin and a large amount of vitamin, can improve the contractility and the frequency of heart, nervous system is had excitation, but its decocting liquid significant prolongation mice swimming time has obvious antifatigue effect; Ganoderma contains rich in amino acid, and trace element etc. can be the body synthetic hemoglobin and furnish ample material, this not only helps the aerobic oxidation ability and strengthens, and the accumulation that helps to delay the generation of lactic acid in the muscle and reduce blood lactic acid, quicken the removing of lactic acid, the fixed quantitative load time lengthening; The Radix Astragali has the enhancing human body immunity function, protects the liver, antibiotic, antidotal effect; Herba Epimedii can stimulate male rabbit to increase the secretory action of testosterone, and allaying tiredness improves results; Herba Cistanches has the effect of rising cortisol levels, can improve the emergency function of human body.

The inventor is based on theory of integrated Chinese and western medicine, adopt pure Chinese drug-treated group cost preparation, each components contents of its material medicine (weight) scope is: Radix Ginseng 250-350 gram, Ganoderma 150-350 gram, Radix Astragali 200-350 gram, Radix Paeoniae Alba 100-300 gram, Radix Curcumae 150-250 gram, Radix Salviae Miltiorrhizae 100-200 gram, Rhizoma Polygonati 200-350 gram, Arillus Longan 100-200 gram, Herba Epimedii 200-300 gram, Herba Cistanches 150-250 gram.According to patient crowd's concrete condition, in described content range, take the circumstances into consideration to adjust for each drug component.

The optimum ratio of each drug component is in the preparation of the present invention: Radix Ginseng 300 grams, Ganoderma 200 grams, the Radix Astragali 300 grams, the Radix Paeoniae Alba 200 grams, Radix Curcumae 150 grams, Radix Salviae Miltiorrhizae 100 grams, Rhizoma Polygonati 200 grams, Arillus Longan 100 grams, Herba Epimedii 200 grams, Herba Cistanches 150 grams.

In addition, the proportioning of each drug component also is preferably in the preparation of the present invention: Radix Ginseng 350 grams, Ganoderma 350 grams, the Radix Astragali 250 grams, the Radix Paeoniae Alba 300 grams, Radix Curcumae 200 grams, Radix Salviae Miltiorrhizae 150 grams, Rhizoma Polygonati 250 grams, Arillus Longan 150 grams, Herba Epimedii 250 grams, Herba Cistanches 200 grams.

The preparation method of capsule preparations in this preparation: 1.Get the oven dry of the medicine in proportion back porphyrize powder in the above-mentioned content range, cross 120 mesh sieves; 2.Medicated powder blendes together one, behind the drying machine inner drying, stirs; 3.With above-mentioned medicated powder, incapsulate through the sterile working, i.e. system; 4.With the medical sterilization method capsule is sterilized; Described medical sterilization method such as irradiation sterilization, commonly used have cobalt-60 irradiation sterilization.

This preparation effect is remarkable, has no side effect, and taking convenience, preparation technology is simple, is the tired pure Chinese medicinal preparation of ideal treatment, can supply wide clinical application.

Toxicity test research of the present invention is as follows:

One, toxicity test

1. half causes death and tests:

Select healthy 20 rat (male and female half and half), body weight 200-400g gets this preparation medicated powder 5g/ and only is dissolved in water, feeds rat, once feeding.Observed 7 days after the administration, do not find the variation of digestive system, respiratory system, nervous system aspect, rat health.

2. big dosis tolerata is measured:

Get 20 of white mice (male and female half and half), body weight 25-40g presses this preparation of 8g/kg lumbar injection medicinal liquid, once injects, and observes 20 white mice health continuously 7 days.The test dosage is equivalent to 40 times of clinical application.

Two, long term toxicity test:

Select healthy 20 rat (male and female half and half), body weight 250-400g presses the 1g/kg amount and irritates stomach with this preparation, and be administered once every day, observed continuously 30 days, do not observe toxicity, and each side such as movable on the feed hair color of rat and body weight are all normal.

Embodiment 1:

The preparation method of capsule preparations in this preparation: 1. get the oven dry of the medicine in proportion back porphyrize powder in the above-mentioned content range, cross 120 mesh sieves; 2. medicated powder blendes together one, behind the drying machine inner drying, stirs; 3. with above-mentioned medicated powder, the zero capsule of packing into through the sterile working (each capsule pack into medicine 0.5g); 4. with the above-mentioned capsule that installs cobalt-60 irradiation sterilization.

Embodiment 2:

Press the optimum ratio of each material medicine content (weight) of this medicament: Radix Ginseng 300 grams, Ganoderma 200 grams, the Radix Astragali 300 grams, the Radix Paeoniae Alba 200 grams, Radix Curcumae 150 restrains, Radix Salviae Miltiorrhizae 100 grams, Rhizoma Polygonati 200 grams, Arillus Longan 100 grams, Herba Epimedii 200 grams, Herba Cistanches 150 restrains; Preparation method with embodiment 1 is made this preparation.

Take this preparation for the patient of 30 ages in 30-50 year, each 5-8 grain, every day three times, three weeks of continuous oral are a course of treatment.Take 1-2 the course of treatment, clinical effectiveness, effective percentage and satisfaction rate are more than 95%.

Wherein a typical case is: the Wang, and the woman, 42 years old, the cadre, it is surplus to state extremely tired half a year, deficiency of QI with disinclination to talk, lack of appetite is indigestion and loss of appetite, dizziness, extremities aching pain, irritated emotional, attention is difficult to concentrate, and often feels afternoon low grade fever, haves a medical check-up and the coherence check no abnormality seen.Take the capsule that this optimum ratio prescription is made, each 5, every day three times, continuous oral is after three weeks, and symptom is obviously improved; After one week of clothes, all diseases disappear, and it is brisk to live.

Embodiment 3:

Press the optimum ratio of each material medicine content (weight) of this medicament: Radix Ginseng 350 grams, Ganoderma 350 grams, the Radix Astragali 250 grams, the Radix Paeoniae Alba 300 grams, Radix Curcumae 200 restrains, Radix Salviae Miltiorrhizae 150 grams, Rhizoma Polygonati 250 grams, Arillus Longan 150 grams, Herba Epimedii 250 grams, Herba Cistanches 200 restrains; Preparation method with embodiment 1 is made this preparation.

Take this preparation for the patient of 30 ages in 30-55 year, each 5-8 grain, every day three times, three weeks of continuous oral are a course of treatment, take 1-2 the course of treatment, clinical effectiveness is good.

Claims (7)

1. treat tired pure Chinese medicinal preparation for one kind.

2. according to right 1 described preparation, its preferred dosage form is a kind of tired pure Chinese medicine capsule preparation for the treatment of.Its material medicine is formed and weight proportion is: Radix Ginseng 250-350 gram, Radix Astragali 200-350 gram, Ganoderma 150-350 gram, Radix Paeoniae Alba 100-300 gram, Radix Curcumae 150-250 gram, Radix Salviae Miltiorrhizae 100-200 gram, Rhizoma Polygonati 200-350 gram, Arillus Longan 100-200 gram, Herba Epimedii 200-300 gram, Herba Cistanches 150-250 gram.

3. preparation according to claim 1, wherein the weight proportion of each raw material is: Radix Ginseng 300 grams, the Radix Astragali 300 grams, Ganoderma 200 grams, the Radix Paeoniae Alba 200 grams, Radix Curcumae 150 grams, Radix Salviae Miltiorrhizae 100 grams, Rhizoma Polygonati 200 grams, Arillus Longan 100 grams, Herba Epimedii 200 grams, Herba Cistanches 150 grams.

4. preparation according to claim 1, wherein the weight proportion of each raw material is: Radix Ginseng 350 grams, the Radix Astragali 250 grams, Ganoderma 350 grams, the Radix Paeoniae Alba 300 grams, Radix Curcumae 200 grams, Radix Salviae Miltiorrhizae 150 grams, Rhizoma Polygonati 250 grams, Arillus Longan 150 grams, Herba Epimedii 250 grams, Herba Cistanches 200 grams.

5. according to the preparation method of the described preparation of claim 2-5,, it is characterized in that, with each medicine oven dry back porphyrize powder of corresponding proportioning, cross 120 mesh sieves, and mix and stir evenly, the said medicine fine powder that stirs evenly is incapsulated, promptly get this preparation.

6. method according to claim 5, after above-mentioned capsule is made, standby behind medical sterilization.

7. according to claim 5 or 6 described methods, after above-mentioned capsule is made, standby after cobalt-60 irradiation is sterilized.