CN1615918A - Chinese medicine effervescent tablet and its preparing method - Google Patents
Chinese medicine effervescent tablet and its preparing method Download PDFInfo
- Publication number
- CN1615918A CN1615918A CN 200310108600 CN200310108600A CN1615918A CN 1615918 A CN1615918 A CN 1615918A CN 200310108600 CN200310108600 CN 200310108600 CN 200310108600 A CN200310108600 A CN 200310108600A CN 1615918 A CN1615918 A CN 1615918A
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- effervescent tablet
- edible
- powder
- fineness
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The Chinese medicine contains four kinds of Chinese medicine components of figwort, ophiopogon root, balloonflower root and licorice. The effervescent Chinese medicine tablet consists of Chinese medicine extractum powder 15-50 wt%, edible carbonate 20-50 wt%, edible organic acid 15-40 wt%, flow assistant 0.1-1 wt% and lubricant 0.5-5 wt%, and may have proper amount of corrective added. The preparation process of the effervescent Chinese medicine tablet features the direct tablet pressing with material powder.
Description
Technical field
The present invention relates to a kind of Chinese medicine effervescent tablet, more specifically relate to a kind of Xuanmai Ganju effervescent tablet that contains Radix Scrophulariae, Radix Ophiopogonis, Radix Platycodonis and Radix Glycyrrhizae four flavor Chinese medicine ingredients.
The invention still further relates to the preparation method of this effervescent tablet.
Background technology
The prescription of being made up of Radix Scrophulariae, Radix Ophiopogonis, Radix Platycodonis and Radix Glycyrrhizae four flavor Chinese medicine equal portions comes from that " Chinese pharmacopoeia version in 2000 is recorded " Xuanmai Ganju granule " (440 pages).Has tool heat clearing away YIN nourishing, the effect of dispelling phlegm and relieving sore-throat.Be used for hyperactivity of fire caused by deficiency of YIN, asthenic fire floating upward, mouth and nose drying, laryngopharynx swelling and pain.Be that pharyngolaryngitis, bronchitis see that above-mentioned patient is suitable for.Hyperactivity of fire caused by deficiency of YIN causes the mouth and nose drying, laryngopharynx swelling and pain is popular is called " getting angry ", and common disease is because of how each human body card and exopathogenic factor show effect repeatedly.
But this granule uses more cane sugar powder and dextrin preparation, and the four Chinese medicine material that adds prescription is and is rich in polysaccharide, gelationus plant roots and stems, and the finished product that wet granulation obtains can comparatively fast dissolve under needing to stir in hot water fully, becomes the medicinal liquid that can take.In the general suitable warm water cold water of drinking, be difficult to dissolving fully.Inconvenience during use.Add and contain more sugar part, needing to be not suitable for the patient of restriction sugar part absorption.
Summary of the invention
The objective of the invention is to overcome Xuanmai Ganju granule sugar content height, not diffluent defective provides the Xuanmai Ganju effervescent tablet of the quick Instant Drinks of a kind of energy, and this effervescent tablet has better ease of use and good mouthfeel.Increase compliance of patients, thereby guarantee drug effect.
Another object of the present invention is to provide the preparation method of this effervescent tablet.
Effervescent tablet of the present invention is formed (by weight) composed as follows of effervescent tablet of the present invention by the extract powder, edible carbonate, edible organic acid, fluidizer and the lubricant that wait weight portion Radix Scrophulariae, Radix Ophiopogonis, Radix Platycodonis and Radix Glycyrrhizae four flavor Chinese medicines to make:
Chinese medical concrete powder 15%～50%
Edible carbonate 20%～50%
Edible organic acid 15%～40%
Fluidizer 0.1%～1%
Lubricant 0.5%～5%
In the above-mentioned prescription, the Chinese medical concrete powder Radix Scrophulariae, Radix Ophiopogonis, Radix Platycodonis and the Radix Glycyrrhizae of weight portion such as serves as reasons through decocting with water the powder that extraction, concentrate drying are made, and its water content should be smaller or equal to 4%, and fineness is 100～300 orders; Edible carbonate adopts sodium bicarbonate or sodium carbonate or sodium bicarbonate and sodium carbonate to mix and uses, and fineness is 60～100 orders, should be 105～120 ℃ of dryings 2～4 hours before using; The edible organic acid adopts one or both in citric acid, the tartaric acid etc., and fineness is should be 105～110 ℃ of dryings 2～4 hours before 60～100 orders use; Fluidizer adopts micropowder silica gel, and its fineness is mean diameter 20～40nm; Lubricant adopts Polyethylene Glycol, fumaric acid, adipic acid, and its fineness is 100～200 orders.
Can also comprise correctives in the above-mentioned according to actual needs prescription.Correctives can adopt acesulfame potassium, cyclamate or protein sugar and aromatic, and as fruit type powdered flavor and Herba Menthae powdered flavor, the consumption of correctives is 0.5～5% (by weight), and fineness is 100～150 orders.
The preparation method of effervescent tablet of the present invention is:
1, the preparation of Chinese medical concrete powder: in etc. the weight portion ratio take by weighing Radix Scrophulariae, Radix Ophiopogonis, Radix Platycodonis and Radix Glycyrrhizae four flavor Chinese medicines, adding 10 times of water gagings decocted 4 hours, the filter press method is filtered, the elimination medicinal residues, the decocting liquid vacuum concentration is to doing, or vacuum concentration to Baume degrees is 1.1～1.3, uses the spray drying method drying instead, promptly gets extract powder.
2, each component pulverized on request, sieved, drying gets the raw materials ready, and takes by weighing Chinese medical concrete powder, edible carbonate, edible organic acid and fluidizer, correctives, lubricant by formula proportion then.
3, press the order of Chinese medical concrete powder, edible organic acid, edible carbonate, correctives, fluidizer and lubricant, reinforced successively, in double cone mixer, mixed 5～15 minutes behind every adding one taste substance, make mix homogeneously.
4, direct powder compression molding.At temperature 15-25 ℃, under the environment of relative humidity 30～45%, use the punch die of 2～2.5 centimetres of diameters, compression moulding on tablet machine, every heavy 2～4 grams.
Beneficial effect:
1, effervescent tablet of the present invention is compared with traditional granule, has convenient, fast, novel features, not limited by water temperature, cold drink, hot drink all can, no residue does not contain sucrose, the taste sweetness is pleasant.
2, the present invention is effectively applied to the effervescent technology to form the effervescent tablet of Instant Drinks fast, to make it to have better ease of use and good mouthfeel in the Chinese patent medicine preparation.Increase compliance of patients, thereby guarantee drug effect.
3, the present invention adopts the method for direct compression of full-powder to prepare effervescent tablet, makes effervescent tablet outward appearance and various component uniformity, and simple for process.
The specific embodiment
The present invention is further elaborated below in conjunction with specific embodiment, but do not limit the present invention.
Embodiment 1
Chinese medical concrete powder 600 gram natrium carbonicum calcinatums 700 gram recemic-tartaric acids 500 grams
Anhydrous citric acid 200 gram polyethylene glycol 6000s 100 gram powder Herba Menthae essence 20 grams
Acesulfame potassium 20 gram micropowder silica gels 5 grams
In the present embodiment, the water content of Chinese medical concrete powder should be less than 4%, its preparation method is: in waiting weight portion ratio to take by weighing Radix Scrophulariae, Radix Ophiopogonis, Radix Platycodonis and Radix Glycyrrhizae, adding 10 times of decoctings boiled 4 hours, 300 order filter clothes, pressure filtration, the decocting liquid vacuum concentration is to doing relative density 1.1-1.3, spray drying promptly gets extract powder again.Other component raw material are commercially available pharmaceutical grade or food stage commodity, and wherein powder Herba Menthae essence is the general board flavorant of love that Aipu Flavouring Co., Ltd., Shanghai produces; The food stage sulfacetamide potassium that the match of peace honey is produced for Beijing dimension polyvoltine worker company limited, commodity are called " dimension polysaccharide "; Micropowder silica gel is the triumphant chemical company limited production of German prestige (meeting USP24 version standard); Polyethylene glycol 6000 is that excipient substance factory of Liaoyang Huaxing produces polyethylene glycol 6000, meets medicinal standard; The food stage soda that natrium carbonicum calcinatum is; Recemic-tartaric acid is the DL-tartaric acid that Yuan Ji chemical plant, Shanghai produces; Anhydrous citric acid is the medicinal anhydrous citric acid that the big chemical industry company limited in Hangzhou side is produced.Married operation carries out in double cone mixer in the effervescent tablet preparation process, and mixing velocity is 15rpm; Tabletting uses the punch die of diameter as 2.0cm, and the TDK type tablet machine of producing with the Far East, Shanghai medical machinery factory carries out compression molding.
Effervescent tablet step preparation by the following method:
1, after following processing, be stored in the exsiccator each component raw material standby respectively:
The Chinese medical concrete powder is crossed 100 mesh sieves; Natrium carbonicum calcinatum is crushed to by behind 80 mesh sieves, puts 105 ℃ of aeration-dryings 3～4 hours; Recemic-tartaric acid and anhydrous citric acid pulverize separately are put 105 ℃ of aeration-dryings 3～4 hours to by behind 80 mesh sieves; Polyethylene glycol 6000 is crossed 200 mesh sieves; Powder Herba Menthae essence is crossed 100 mesh sieves; Peace honey is better than 100 mesh sieves.
2, take by weighing each component by above-mentioned formula proportion, in the Chinese medical concrete powder, add anhydrous citric acid, mixed 5 minutes, add recemic-tartaric acid then, mix and add natrium carbonicum calcinatum after 5 minutes, continue to mix 5 minutes, added powdered flavor and acesulfame potassium more mixed 5 minutes, add micropowder silica gel and mixed 10 minutes, add polyethylene glycol 6000 at last and mixed 5 minutes, make uniform mixed-powder.
3, under 25 ℃, relative humidity are 45% environmental condition, powder is carried out tabletting, make effervescent tablet, every heavily about 2.2 grams.
Zhi Bei effervescent tablet places 250 ml waters as stated above, can all be dissolved into light brown settled solution, taste and sweet mouthfeel about 4 minutes.
Claims (8)
1, a kind of Chinese medicine effervescent tablet, its composition (by weight) is:
Chinese medical concrete powder 15%～50%
Edible carbonate 20%～50%
Edible organic acid 15%～40%
Fluidizer 0.1%～1%
Lubricant 0.5%～5%
Wherein Chinese medical concrete powder Radix Scrophulariae, Radix Ophiopogonis, Radix Platycodonis and the Radix Glycyrrhizae of weight portion such as serve as reasons decocts with water the powder that extraction, concentrate drying are made; Edible carbonate is one or both in sodium bicarbonate and the sodium carbonate; The edible organic acid is one or both in citric acid, the tartaric acid; Fluidizer is micropowder silica gel; Lubricant is Polyethylene Glycol or fumaric acid or adipic acid.
2, Chinese medicine effervescent tablet according to claim 1, the water content that it is characterized in that the Chinese medical concrete powder should be smaller or equal to 4%, and fineness is 100～300 orders, and the edible carbonate fineness is 60～100 orders, edible organic acid fineness is 60～100 orders, and the fluidizer fineness is mean diameter 20～40nm; The lubricant fineness is 100～200 orders.
3, Chinese medicine effervescent tablet according to claim 1 is characterized in that comprising correctives.
4, Chinese medicine effervescent tablet according to claim 3 is characterized in that correctives is cyclamate, acesulfame potassium or protein sugar and aromatic, i.e. fruit type powdered flavor or Herba Menthae powdered flavor.
5, Chinese medicine effervescent tablet according to claim 4, the consumption that it is characterized in that correctives are 0.5～5% (by weight), and fineness is 100～150 orders.
6, the preparation method of the described Chinese medicine effervescent tablet of claim 1, form by the following step:
(1), the preparation of Chinese medical concrete powder: in etc. the weight portion ratio take by weighing Radix Scrophulariae, Radix Ophiopogonis, Radix Platycodonis and Radix Glycyrrhizae four flavor Chinese medicines, adding 10 times of water gagings decocted 4 hours, the filter press method is filtered, the elimination medicinal residues, the decocting liquid vacuum concentration is to doing, or vacuum concentration to Baume degrees is 1.1～1.3, uses the spray drying method drying instead, promptly gets extract powder;
(2), each component is pulverized on request, is sieved, drying gets the raw materials ready, and takes by weighing Chinese medical concrete powder, edible carbonate, edible organic acid and fluidizer, correctives, lubricant by formula proportion then;
(3), the order of pressing Chinese medical concrete powder, edible organic acid, edible carbonate, correctives, fluidizer and lubricant, reinforced successively, in double cone mixer, mixed 5～15 minutes behind every adding one taste substance, make mix homogeneously;
(4), direct powder compression molding.
7, the preparation method of Chinese medicine effervescent tablet according to claim 6, it is characterized in that adopting the direct powder compression moulding process, tabletting carries out under 15～25 ℃, the environment of relative humidity 30～45%, use the punch die of 2～2.5 centimetres of diameters, compression moulding on tablet machine, every heavy 2～4 grams.
8, the preparation method of Chinese medicine effervescent tablet according to claim 6 is characterized in that edible carbonate before use should be 105～120 ℃ of dryings 2～4 hours; The edible organic acid before use should be 105～110 ℃ of dryings 2～4 hours.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310108600 CN1615918A (en) | 2003-11-13 | 2003-11-13 | Chinese medicine effervescent tablet and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310108600 CN1615918A (en) | 2003-11-13 | 2003-11-13 | Chinese medicine effervescent tablet and its preparing method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1615918A true CN1615918A (en) | 2005-05-18 |
Family
ID=34758639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200310108600 Pending CN1615918A (en) | 2003-11-13 | 2003-11-13 | Chinese medicine effervescent tablet and its preparing method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1615918A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103893536A (en) * | 2014-03-25 | 2014-07-02 | 南京信息工程大学 | Composition and effervescent tablet for preventing and treating haze-induced pharyngitis |
| CN103989920A (en) * | 2014-04-22 | 2014-08-20 | 安徽省太湖山中药饮片有限公司 | Sunflower seed kernel and dwarf lilyturf tuber effervescent tablet and preparation method thereof |
| CN105231247A (en) * | 2015-08-31 | 2016-01-13 | 青岛海之源智能技术有限公司 | Fruit and vegetable multivitamin effervescent tablet and preparation method thereof |
| CN105942130A (en) * | 2016-05-04 | 2016-09-21 | 广州聚注专利研发有限公司 | Effervescent tablet beverage with efficacy of promoting digestion of intestine and stomach |
-
2003
- 2003-11-13 CN CN 200310108600 patent/CN1615918A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103893536A (en) * | 2014-03-25 | 2014-07-02 | 南京信息工程大学 | Composition and effervescent tablet for preventing and treating haze-induced pharyngitis |
| CN103989920A (en) * | 2014-04-22 | 2014-08-20 | 安徽省太湖山中药饮片有限公司 | Sunflower seed kernel and dwarf lilyturf tuber effervescent tablet and preparation method thereof |
| CN105231247A (en) * | 2015-08-31 | 2016-01-13 | 青岛海之源智能技术有限公司 | Fruit and vegetable multivitamin effervescent tablet and preparation method thereof |
| CN105942130A (en) * | 2016-05-04 | 2016-09-21 | 广州聚注专利研发有限公司 | Effervescent tablet beverage with efficacy of promoting digestion of intestine and stomach |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1265715C (en) | Bitter gourd cold tea and its production method | |
| CN101617800A (en) | Fructus phyllanthi buccal tablet and preparation method thereof | |
| CN100542584C (en) | Compound hippophae rhamnoides lozenge and preparation method thereof | |
| CN100556401C (en) | Effervescence tablet for cold | |
| CN1170560C (en) | Health care tea and production method thereof | |
| CN101062102A (en) | Material formula of olive microcapsule effervescent tablets and the preparing method thereof | |
| CN1824272A (en) | Alpinia eye brightening drink and its manufacturing method | |
| CN104771567A (en) | Alcohol-effect-dispelling pharmaceutical composition | |
| CN1615918A (en) | Chinese medicine effervescent tablet and its preparing method | |
| CN110881555A (en) | Dispersible candy tablet with dual-effect of lowering blood pressure | |
| CN1156031A (en) | Oral medicine for dropping blood lead and its preparing method | |
| CN101095709A (en) | Panax notoginseng floral leaf effervescent tablets and method for preparing the same | |
| CN1064539C (en) | Internal heat-reducing cooling tea | |
| CN107361281B (en) | Momordica grosvenori effervescent tablet and preparation method thereof | |
| CN100546570C (en) | Effervescence tablet for treating wind-cold type cold | |
| CN1270039A (en) | Chewing tablets of pilose antler, deerhorn and deer bone and preparing process thereof | |
| CN100563634C (en) | A kind of Herba Sidae Rhombifoliae soup drop pill | |
| CN1456247A (en) | Preparation of double coptis root effervescent tablets | |
| CN107581609A (en) | A kind of garlic peptide composition | |
| CN1663590A (en) | Buccal tablet of chrysanthemum flower | |
| CN1736415A (en) | Effervescence tablet of 'Shuang Huanglian' and its preparation process thereof | |
| CN101152424A (en) | Pharmaceutical composition of snake bile and tendril-leaved fritillary bulb, and preparations of the same | |
| CN100348178C (en) | 'Ganjing' dripping pills for treating liver disease and its preparation | |
| CN1562314A (en) | Effervesce tablet of reducing fever and detoxicating and preparation method | |
| CN102920963B (en) | The preparation technology of acute and chronic pharyngitis medicine scale |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |