CN101095709A - Panax notoginseng floral leaf effervescent tablets and method for preparing the same - Google Patents
Panax notoginseng floral leaf effervescent tablets and method for preparing the same Download PDFInfo
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- CN101095709A CN101095709A CNA2006100109832A CN200610010983A CN101095709A CN 101095709 A CN101095709 A CN 101095709A CN A2006100109832 A CNA2006100109832 A CN A2006100109832A CN 200610010983 A CN200610010983 A CN 200610010983A CN 101095709 A CN101095709 A CN 101095709A
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- hydroxypropyl starch
- floral leaf
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- sodium bicarbonate
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Abstract
The invention relates to a kind of medicine that takes plant extract as medical effective component and the method for preparing the same. The comprised components in effervescence and their proportions (by weight)are as follows: pseudo-ginseng flower and leaves and stem extract 10-40%, the left is medical findings; said findings comprises: urinary citric acid 6-20%, sodium acid carbonate 10-30%, macrogol 6000 2-10%, lactose 20-50%, stevia rebaudiava 2-10%, hydroxypropyl starch 5-15%, silicon micronized quartz powder 0.2-1%, and dolomol 0.5-1.5%. The method comprises following steps: disintegrating and screening pseudo-ginseng flower and leaves and stem extract, urinary citric acid, stevia rebaudiava, hydroxypropyl starch, silicon micronized quartz powder with 80 order screen, producing particle with 70-95% ethanol, drying at 60-80 Deg. C, getting particle, adding macrogol 6000 into sodium acid carbonate, stirring evenly, cooling and disintegrating, mixing with said particle and dolomol, sheeting and packing with complex memebrane.
Description
Technical field
The present invention relates to a kind of is medicine effective medicinal components, special form with the plant extract, and preparation method.
Background technology
Former dosage form notoginseng floral leaf granule is the granule of being made by flower of Radix Notoginseng, notoginseng leaf extract of my company exploitation seventies, and this medicine was once once being sold well.This medicine can be used for the furuncle that heat in blood causes; As the normal comedo of suffering from of adolescence,, headache fidgety, dizzy, insomnia etc. by the cardiopalmus that liver-heat causes.Because this medicine contains multiple active ingredient with physiologically active, makes this its treatment face of medicine more, both having can be used as medicine for treatment also has health-care effect preferably, but because dosage form is single, the scope of application is restricted.
Summary of the invention
The objective of the invention is to overcome the defective of prior art, provide a kind of new pharmaceutic adjuvant that contains, the notoginseng floral leaf novel pharmaceutical formulation that stability of drug and quality standard all are improved.
Another object of the present invention is to provide the preparation method of this new drug formulation.
Panax notoginseng floral leaf effervescent tablets of the present invention is made up of following component in percentage by weight: notoginseng floral leaf stem water extract 10-40%, surplus is a pharmaceutic adjuvant.
Described notoginseng floral leaf stem water extract is made by following method: get Radix Notoginseng, leaf, stem and decoct with water, each 1 hour, collecting decoction filtered, filtrate in 70 ℃ of vacuum concentration to flowing clear paste, the stream clear paste in 50-80 ℃ of vacuum drying, beat the powder sieving for standby.
Described pharmaceutic adjuvant is: citric acid 6-20%, sodium bicarbonate 10-30%, polyethylene glycol 6000 2-10%, lactose 20-50%, steviosin 2-10%, hydroxypropyl starch 5-15%, micropowder silica gel 0.2-1%, magnesium stearate 0.5-1.5%.
In above-mentioned pharmaceutic adjuvant, also can add an amount of Fructus Citri Limoniae essence.
Effervescent tablet of the present invention is the major ingredient at this medicine---a kind of tablet that the character of notoginseng floral leaf stem water extract is made with organic acid and bicarbonate or carbonate disintegrating agent, correctives, and add the new type medicinal stuff hydroxypropyl starch and accelerate the medicine disintegrate, adopt Polyethylene Glycol microcapsule pack new technology to improve medicine stability.Because notoginseng floral leaf stem water extract viscosity is bigger, adopts general disintegrating agent often not reach ideal disintegrate purpose, must add disintegrating property preferably hydroxypropyl starch be disintegrating agent and adopt two to go on foot granulations.
Citric acid, sodium bicarbonate and hydroxypropyl starch are disintegrating agent in the above-mentioned selected adjuvant, and lactose is a diluent, and micropowder silica gel, magnesium stearate are lubricant, and polyethylene glycol 6000 is as the packaging material lubricant.Bronsted lowry acids and bases bronsted lowry produces chemical reaction and produces the disintegrate of carbon dioxide formation foam in the preparation after effervescent tablet is met water, and hydroxypropyl starch can quicken the preparation disintegrate and have lubricity preferably.
The present invention shows through toxicity test and has no side effect that its pharmacodynamics test is the pharmacodynamics test of effective ingredient.
Effervescent tablet of the present invention is put into water can produce the rapid disintegrate of a large amount of bubbles, forms clear and delicious solution.Have heat clearing away, removing heat from blood, suppressing the hyperactive liver, YANG hyperactivity suppressing function, be used for the furuncle that heat in blood causes; Fidgety, dizzy by the cardiopalmus that liver-heat causes, the headache, the insomnia.This medicine is beneficial to absorption, carries, taking convenience, mouthfeel are better, is easy to accept into patient.The more former dosage form of panax notoginseng floral leaf effervescent tablets significantly reduces sugared dose, and is more favourable to diabetic to take.Because effervescent tablet preparation formulation is novel, is suitable for child, old man and dysphagia patients and takes.Especially catered to teenager and liked new, strange, special characteristics, had remarkable advantages in child, teenager field.
The preparation method of panax notoginseng floral leaf effervescent tablets of the present invention is:
Get notoginseng floral leaf stem water extract, citric acid, steviosin, hydroxypropyl starch, micropowder silica gel in proportion and pulverized 80 mesh sieves, use the 70-95% alcohol granulation, 60-80 ℃ of drying, granulate are standby; Taking polyethylene glycol 6000 fusions adding sodium bicarbonate stirs in addition, is ground into fine powder after the cooling, with above-mentioned granule, magnesium stearate mixing, tabletting, composite film packaging.
In the technology of the present invention for make said preparation as far as possible in short time (in 5 minutes) disintegrate, adopt two step granulations in the technology of the present invention, promptly principal agent is granulated with the part disintegrating agent earlier, again with residue disintegrating agent and other adjuvant tabletting method that is mixed.In the technology of the present invention for make said preparation have preferably stability we adopted acid, alkali is granulated respectively and the pack of Polyethylene Glycol microcapsule, is about to after Polyethylene Glycol and sodium bicarbonate mixing, fusion, the pulverizing granule mixed pressuring plate with principal agent and acid, adjuvant again.The present invention more former dosage form in quality standard has increased in stem and leaf of Radix Notoginseng Saponin, ginsenoside Rb1, Ginsenoside Rb's 3 identification check and the high effective liquid chromatography for measuring preparation Ginsenoside Rb's 3 content with the standard that improves the quality.
The specific embodiment
Embodiment:
1,25 parts of Radix Notoginseng base of leaf extracts, 75 parts of pharmaceutic adjuvants.In the pharmaceutic adjuvant: 15 parts of citric acids, 20 parts of sodium bicarbonate, 8 parts of polyethylene glycol 6000s, 37 parts of lactose, 8 parts of steviosin, 10 parts of hydroxypropyl starch, 0.8 part of micropowder silica gel, 1.2 parts of magnesium stearate.
Get Radix Notoginseng base of leaf extract, citric acid, steviosin, lactose, hydroxypropyl starch, micropowder silica gel and pulverized 80 mesh sieves, use 95% alcohol granulation, 60-80 ℃ of drying, granulate are standby, taking polyethylene glycol 6000 fusions adding sodium bicarbonate stirs in addition, be ground into fine powder after the cooling, cross 80 mesh sieves, with above-mentioned granule, magnesium stearate mixing, be pressed into 1000.
2,15 parts of Radix Notoginseng base of leaf extracts, 85 parts of pharmaceutic adjuvants.In the pharmaceutic adjuvant: 20 parts of citric acids, 15 parts of sodium bicarbonate, 8 parts of polyethylene glycol 6000s, 35 parts of lactose, 8 parts of steviosin, 12 parts of hydroxypropyl starch, 0.7 part of micropowder silica gel, 1.3 parts of magnesium stearate.
Get Radix Notoginseng base of leaf extract, citric acid, lactose, steviosin, hydroxypropyl starch, micropowder silica gel and pulverized 80 mesh sieves, 75% ethanol liquid is granulated, 60-80 ℃ of drying, granulate are standby, taking polyethylene glycol 6000 fusions adding sodium bicarbonate stirs in addition, be ground into fine powder after the cooling, cross 80 mesh sieves, with above-mentioned granule, magnesium stearate mixing, be pressed into 1000.
3,15 parts of Radix Notoginseng base of leaf extracts, 85 parts of pharmaceutic adjuvants.In the pharmaceutic adjuvant: 18 parts of citric acids, 14 parts of sodium bicarbonate, 9 parts of polyethylene glycol 6000s, 42 parts of lactose, 6 parts of steviosin, 9 parts of hydroxypropyl starch, 0.9 part of micropowder silica gel, 1.1 parts of magnesium stearate.
Get Radix Notoginseng base of leaf extract, citric acid, lactose, steviosin, hydroxypropyl starch, micropowder silica gel and pulverized 80 mesh sieves, granulate with alcohol 95 %, 60-80 ℃ of drying, granulate are standby, taking polyethylene glycol 6000 fusions adding sodium bicarbonate stirs in addition, be ground into fine powder after the cooling, cross 80 mesh sieves, with above-mentioned granule, magnesium stearate mixing, be pressed into 1000.
4,25 parts of Radix Notoginseng base of leaf extracts, 75 parts of pharmaceutic adjuvants.In the pharmaceutic adjuvant: 20 parts of citric acids, 20 parts of sodium bicarbonate, 7 parts of polyethylene glycol 6000s, 34 parts of lactose, 5 parts of steviosin, 12 parts of hydroxypropyl starch, 0.8 part of micropowder silica gel, 1.2 parts of magnesium stearate.
Get Radix Notoginseng base of leaf extract, citric acid, lactose, steviosin, hydroxypropyl starch, micropowder silica gel and pulverized 80 mesh sieves, granulate with 90% ethanol liquid, 60-80 ℃ of drying, granulate are standby, taking polyethylene glycol 6000 fusions adding sodium bicarbonate stirs in addition, be ground into fine powder after the cooling, cross 80 mesh sieves, with above-mentioned granule, magnesium stearate mixing, be pressed into 1000.
5,25 parts of Radix Notoginseng base of leaf extracts, 75 parts of pharmaceutic adjuvants.In the pharmaceutic adjuvant: 14 parts of citric acids, 14 parts of sodium bicarbonate, 7 parts of polyethylene glycol 6000s, 50 parts of lactose, 5 parts of steviosin, 8 parts of hydroxypropyl starch, 0.8 part of micropowder silica gel, 1.2 parts of magnesium stearate.
Get Radix Notoginseng base of leaf extract, citric acid, lactose, steviosin, hydroxypropyl starch, micropowder silica gel and pulverized 80 mesh sieves, use 90% alcohol granulation, 60-80 ℃ of drying, granulate are standby, taking polyethylene glycol 6000 fusions adding sodium bicarbonate stirs in addition, be ground into fine powder after the cooling, cross 80 mesh sieves, with above-mentioned granule, magnesium stearate mixing, be pressed into 1000.
6,25 parts of Radix Notoginseng base of leaf extracts, 75 parts of pharmaceutic adjuvants.In the pharmaceutic adjuvant: 18 parts of citric acids, 14 parts of sodium bicarbonate, 9 parts of polyethylene glycol 6000s, 42 parts of lactose, 6 parts of steviosin, 9 parts of hydroxypropyl starch, 0.9 part of micropowder silica gel, 1.1 parts of magnesium stearate.
Get Radix Notoginseng base of leaf extract, citric acid, lactose, steviosin, hydroxypropyl starch, micropowder silica gel and pulverized 80 mesh sieves, granulate with 75% ethanol liquid, 60-80 ℃ of drying, granulate are standby, taking polyethylene glycol 6000 fusions adding sodium bicarbonate stirs in addition, be ground into fine powder after the cooling, cross 80 mesh sieves, with above-mentioned granule, magnesium stearate mixing, be pressed into 1000.
7,30 parts of Radix Notoginseng base of leaf extracts, 70 parts of pharmaceutic adjuvants.In the pharmaceutic adjuvant: 14 parts of citric acids, 14 parts of sodium bicarbonate, 7 parts of polyethylene glycol 6000s, 50 parts of lactose, 5 parts of steviosin, 8 parts of hydroxypropyl starch, 0.8 part of micropowder silica gel, 1.2 parts of magnesium stearate.
Get Radix Notoginseng base of leaf extract, citric acid, lactose, polyethylene glycol 6000, steviosin, hydroxypropyl starch, micropowder silica gel and pulverized 80 mesh sieves, granulate with 70% ethanol liquid, 60-80 ℃ of drying, granulate are standby, and other gets sodium bicarbonate, magnesium stearate mixing, is pressed into 1000.
8,30 parts of Radix Notoginseng base of leaf extracts, 70 parts of pharmaceutic adjuvants.In the pharmaceutic adjuvant: 20 parts of citric acids, 15 parts of sodium bicarbonate, 8 parts of polyethylene glycol 6000s, 35 parts of lactose, 8 parts of steviosin, 12 parts of hydroxypropyl starch, 0.7 part of micropowder silica gel, 1.3 parts of magnesium stearate.
Get Radix Notoginseng base of leaf extract, citric acid, polyethylene glycol 6000, lactose, steviosin, hydroxypropyl starch, micropowder silica gel and pulverized 80 mesh sieves, use 95% alcohol granulation, 60-80 ℃ of drying, granulate are standby, and other gets sodium bicarbonate, magnesium stearate mixing, is pressed into 1000.
9,15 parts of Radix Notoginseng base of leaf extracts, 85 parts of pharmaceutic adjuvants.In the pharmaceutic adjuvant: 10 parts of citric acids, 20 parts of sodium bicarbonate, 7 parts of polyethylene glycol 6000s, 46 parts of lactose, 5 parts of steviosin, 10 parts of hydroxypropyl starch, 0.8 part of micropowder silica gel, 1.2 parts of magnesium stearate.
Get notoginseng floral leaf stem extract, polyethylene glycol 6000, lactose, steviosin, hydroxypropyl starch, micropowder silica gel and pulverized 80 mesh sieves, use 85% alcohol granulation, 60-80 ℃ of drying, granulate are standby, and other gets citric acid, sodium bicarbonate, magnesium stearate mixing, is pressed into 1000.
10,20 parts of Radix Notoginseng base of leaf extracts, 80 parts of pharmaceutic adjuvants.In the pharmaceutic adjuvant: 14 parts of citric acids, 14 parts of sodium bicarbonate, 7 parts of polyethylene glycol 6000s, 50 parts of lactose, 5 parts of steviosin, 8 parts of hydroxypropyl starch, 0.8 part of micropowder silica gel, 1.2 parts of magnesium stearate.
Get notoginseng floral leaf stem extract, polyethylene glycol 6000, lactose, steviosin, hydroxypropyl starch, micropowder silica gel and pulverized 80 mesh sieves, use 75% alcohol granulation, 60-80 ℃ of drying, granulate are standby, and other gets citric acid, sodium bicarbonate, magnesium stearate mixing, is pressed into 1000, composite film packaging.
Claims (3)
1, a kind of panax notoginseng floral leaf effervescent tablets is characterized in that being made up of following component in percentage by weight: notoginseng floral leaf stem water extract 10-40%, surplus is a pharmaceutic adjuvant.
2, panax notoginseng floral leaf effervescent tablets as claimed in claim 1 is characterized in that described pharmaceutic adjuvant is: citric acid 6-20%, sodium bicarbonate 10-30%, polyethylene glycol 6000 2-10%, lactose 20-50%, steviosin 2-10%, hydroxypropyl starch 5-15%, micropowder silica gel 0.2-1%, magnesium stearate 0.5-1.5%.
3, as the preparation method of claim 1 and 2 described panax notoginseng floral leaf effervescent tablets, it is characterized in that getting notoginseng floral leaf stem water extract, citric acid, steviosin, hydroxypropyl starch, micropowder silica gel in described ratio pulverized 80 mesh sieves, use the 70-95% alcohol granulation, 60-80 ℃ of drying, granulate are standby; Taking polyethylene glycol 6000 fusions adding sodium bicarbonate stirs in addition, is ground into fine powder after the cooling, with above-mentioned granule, magnesium stearate mixing, tabletting, composite film packaging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006100109832A CN101095709A (en) | 2006-06-26 | 2006-06-26 | Panax notoginseng floral leaf effervescent tablets and method for preparing the same |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006100109832A CN101095709A (en) | 2006-06-26 | 2006-06-26 | Panax notoginseng floral leaf effervescent tablets and method for preparing the same |
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| CN101095709A true CN101095709A (en) | 2008-01-02 |
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| CNA2006100109832A Pending CN101095709A (en) | 2006-06-26 | 2006-06-26 | Panax notoginseng floral leaf effervescent tablets and method for preparing the same |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101919802A (en) * | 2009-07-14 | 2010-12-22 | 无锡健而乐医药科技有限公司 | Solid effervescent mixture for the oral absorption |
| CN102335229A (en) * | 2011-09-26 | 2012-02-01 | 江西济民可信药业有限公司 | Preparation method of gynecological inflammation clearing vaginal effervescent tablet |
| CN106036903A (en) * | 2016-06-08 | 2016-10-26 | 彭常安 | Preparation method of phallus indusiatus and panax notoginseng flower effervescent tablets |
| CN115737583A (en) * | 2022-12-21 | 2023-03-07 | 中国中医科学院中药研究所 | Effervescent tablet for enhancing exercise endurance and preparation method thereof |
-
2006
- 2006-06-26 CN CNA2006100109832A patent/CN101095709A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101919802A (en) * | 2009-07-14 | 2010-12-22 | 无锡健而乐医药科技有限公司 | Solid effervescent mixture for the oral absorption |
| CN102335229A (en) * | 2011-09-26 | 2012-02-01 | 江西济民可信药业有限公司 | Preparation method of gynecological inflammation clearing vaginal effervescent tablet |
| CN102335229B (en) * | 2011-09-26 | 2013-04-03 | 江西济民可信药业有限公司 | Preparation method of gynecological inflammation clearing vaginal effervescent tablet |
| CN106036903A (en) * | 2016-06-08 | 2016-10-26 | 彭常安 | Preparation method of phallus indusiatus and panax notoginseng flower effervescent tablets |
| CN115737583A (en) * | 2022-12-21 | 2023-03-07 | 中国中医科学院中药研究所 | Effervescent tablet for enhancing exercise endurance and preparation method thereof |
| CN115737583B (en) * | 2022-12-21 | 2024-05-28 | 中国中医科学院中药研究所 | Effervescent tablet for enhancing exercise endurance and preparation method thereof |
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