CN1615823A - 一种鼻喷剂 - Google Patents
一种鼻喷剂 Download PDFInfo
- Publication number
- CN1615823A CN1615823A CN 200410046798 CN200410046798A CN1615823A CN 1615823 A CN1615823 A CN 1615823A CN 200410046798 CN200410046798 CN 200410046798 CN 200410046798 A CN200410046798 A CN 200410046798A CN 1615823 A CN1615823 A CN 1615823A
- Authority
- CN
- China
- Prior art keywords
- nasal spray
- acrylate polymer
- spray agent
- release agent
- medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003795 chemical substances by application Substances 0.000 title claims abstract description 25
- 239000007921 spray Substances 0.000 title abstract description 9
- 229920000058 polyacrylate Polymers 0.000 claims abstract description 12
- 239000007922 nasal spray Substances 0.000 claims description 40
- 229940097496 nasal spray Drugs 0.000 claims description 39
- 239000000203 mixture Substances 0.000 claims description 13
- 150000003431 steroids Chemical class 0.000 claims description 3
- 239000003814 drug Substances 0.000 abstract description 16
- 210000003928 nasal cavity Anatomy 0.000 abstract description 4
- 210000001331 nose Anatomy 0.000 abstract description 4
- 229930182558 Sterol Natural products 0.000 abstract 1
- 230000007721 medicinal effect Effects 0.000 abstract 1
- 210000004400 mucous membrane Anatomy 0.000 abstract 1
- 125000002328 sterol group Chemical group 0.000 abstract 1
- 235000003702 sterols Nutrition 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 11
- 229920002125 Sokalan® Polymers 0.000 description 10
- 239000004744 fabric Substances 0.000 description 9
- 230000015556 catabolic process Effects 0.000 description 7
- 238000006731 degradation reaction Methods 0.000 description 7
- 239000012535 impurity Substances 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 3
- 210000003097 mucus Anatomy 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 2
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 229960001574 benzoxonium chloride Drugs 0.000 description 2
- 229960004436 budesonide Drugs 0.000 description 2
- 210000002421 cell wall Anatomy 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 239000003055 low molecular weight heparin Substances 0.000 description 2
- 229940127215 low-molecular weight heparin Drugs 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- PXGPLTODNUVGFL-JZFBHDEDSA-N prostaglandin F2beta Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@@H](O)[C@@H]1C\C=C/CCCC(O)=O PXGPLTODNUVGFL-JZFBHDEDSA-N 0.000 description 2
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- YXKFATPOEMHNMJ-KJEYTGHBSA-N Cormethasone acetate Chemical compound C1C(F)(F)C2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)COC(C)=O)(O)[C@@]1(C)C[C@@H]2O YXKFATPOEMHNMJ-KJEYTGHBSA-N 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940124599 anti-inflammatory drug Drugs 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- 230000009920 chelation Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229950011211 cormetasone Drugs 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000031891 intestinal absorption Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229960000306 zinc gluconate Drugs 0.000 description 1
- 235000011478 zinc gluconate Nutrition 0.000 description 1
- 239000011670 zinc gluconate Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
天数 | 实施例1 | 实施例2 | 对比实施例1 |
降解杂质含量% | 降解杂质含量% | 降解杂质含量% | |
7 | 0 | 0 | 0.15 |
28 | 0.12 | 0.10 | 0.61 |
63 | 0.30 | 0.27 | 0.59 |
92 | 0.47 | 0.41 | 2.21 |
180 | 0.92 | 0.87 | 4.88 |
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 200410046798 CN1244320C (zh) | 2004-09-27 | 2004-09-27 | 一种鼻喷剂 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 200410046798 CN1244320C (zh) | 2004-09-27 | 2004-09-27 | 一种鼻喷剂 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1615823A true CN1615823A (zh) | 2005-05-18 |
CN1244320C CN1244320C (zh) | 2006-03-08 |
Family
ID=34763862
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 200410046798 Active CN1244320C (zh) | 2004-09-27 | 2004-09-27 | 一种鼻喷剂 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1244320C (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106214926A (zh) * | 2016-07-29 | 2016-12-14 | 腾科宝迪(厦门)生物科技有限公司 | 一种鼻喷雾剂及其制备方法 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7353004B2 (en) * | 2001-11-01 | 2008-04-01 | Broadlogic Network Technologies, Inc. | Multi-channel broadband content distribution system |
-
2004
- 2004-09-27 CN CN 200410046798 patent/CN1244320C/zh active Active
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106214926A (zh) * | 2016-07-29 | 2016-12-14 | 腾科宝迪(厦门)生物科技有限公司 | 一种鼻喷雾剂及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN1244320C (zh) | 2006-03-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: SHANGHAI FOSUN PUSHI PHARMACEUTICAL TECHNOLOGY CO. Free format text: FORMER OWNER: ZHANG KAI Effective date: 20090403 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20090403 Address after: Shanghai City, Bing Road No. 306 2 floor Patentee after: Shanghai Fosun Pushi Pharmaceutical Technology Co., Ltd. Address before: Room 4, building 101, Furong district, lotus garden, Changsha, Hunan Patentee before: Zhang Kai |
|
ASS | Succession or assignment of patent right |
Owner name: ZHANG KAI Free format text: FORMER OWNER: SHANGHAI FOSUN PUSHI PHARMACEUTICAL TECHNOLOGY CO., LTD. Effective date: 20120716 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20120716 Address after: Pudong Zhangjiang road 201203 Bing Shanghai No. 306 Building No. 3 2 floor Patentee after: Zhang Kai Address before: 201203 Shanghai City Bing Road No. 306 2 floor Patentee before: Shanghai Fosun Pushi Pharmaceutical Technology Co., Ltd. |
|
ASS | Succession or assignment of patent right |
Owner name: SUZHOU OUMINI PHARMACEUTICALS CO., LTD. Free format text: FORMER OWNER: ZHANG KAI Effective date: 20150615 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20150615 Address after: 215421 Taicang city in Jiangsu Province town of Shaxi Biomedical Park Road No. 5, Zhenhui plant No. 6 Patentee after: Suzhou Pharmaceutical Co., Ltd. Address before: Pudong Zhangjiang road 201203 Bing Shanghai No. 306 Building No. 3 2 floor Patentee before: Zhang Kai |
|
CP02 | Change in the address of a patent holder |
Address after: 215421 Shaxi Town, Suzhou, Jiangsu Province, Shaxi Town, bio medicine industrial park, Zhen Xi Road No. 69 Patentee after: Suzhou Pharmaceutical Co., Ltd. Address before: 215421 Taicang city in Jiangsu Province town of Shaxi Biomedical Park Road No. 5, Zhenhui plant No. 6 Patentee before: Suzhou Pharmaceutical Co., Ltd. |
|
CP02 | Change in the address of a patent holder |