CN1613461A - Arthralgia removing pills and their preparation - Google Patents
Arthralgia removing pills and their preparation Download PDFInfo
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- CN1613461A CN1613461A CN 200310103525 CN200310103525A CN1613461A CN 1613461 A CN1613461 A CN 1613461A CN 200310103525 CN200310103525 CN 200310103525 CN 200310103525 A CN200310103525 A CN 200310103525A CN 1613461 A CN1613461 A CN 1613461A
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- 238000002360 preparation method Methods 0.000 title claims description 20
- 208000006820 Arthralgia Diseases 0.000 title description 2
- 239000003814 drug Substances 0.000 claims abstract description 34
- 241000218176 Corydalis Species 0.000 claims abstract description 32
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- 239000007788 liquid Substances 0.000 claims abstract description 14
- 206010058019 Cancer Pain Diseases 0.000 claims abstract description 11
- 239000003826 tablet Substances 0.000 claims abstract description 5
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- 239000002552 dosage form Substances 0.000 claims description 3
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- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
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- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
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- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 3
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Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
A Chinese medicine in the form of particles; tablet, capsule, pill, or oral liquid for treating cancer pain is prepared from 7 Chinese-medicinal materials including corydalis tuber, notogniseng, myrrh, borneol, etc. Its advantages are high curative effect and durability, and no addiction and toxic by-effect.
Description
[invention field]
The present invention relates to a kind of Chinese medicine composition, is a kind of Chinese medicine composition that is used for the treatment of cancer pain specifically, the invention still further relates to the preparation method of this Chinese medicine composition.
[background technology]
Show that according to the Ministry of Public Health statistics Chinese annual cancer patient increases progressively with the million people, just have one family to be subjected to the harm of tumor disease in per 200 families.Wherein pain is an insoluble problem as cancer patient's serious symptoms always.Three stage therapies are recommended to use to the treatment of cancer pain by World Health Organization (WHO), mild pain uses the non-opium antalgica, as acetaminophen, aspirin etc., moderate pain then uses weak opiates antalgica, as codeine, paracetamol ﹠ codeine etc., severe pain is then used strong opiates antalgica, as morphine, methadone etc.Though these strong opiates antalgicas can the respite patient suffering, use continuously easily to produce side effect such as cumulative toxicity and dependency, if improper use more can jeopardize health of human body,
In view of the medicine and the method that not have at present better effectively to treat cancer pain, so a kind of Chinese medicine for oral administration that can effectively treat cancer pain and have no side effect of demand still.The inventor develops a kind of Chinese medicine composition that can effectively treat cancer pain and have no side effect, thereby has finished the present invention through animal experiment and clinical verification repeatedly for many years.
[summary of the invention]
Goal of the invention
Purpose of the present invention just provides a kind of Chinese medicine composition that can effectively treat cancer pain.This medicine has the effect of regulating qi to disperse stagnation, removing obstruction in the collateral to relieve pain, can be used for costalgia, pain heavy treatment at night that qi depression to blood stasis causes, to the treatment cancerous pain have that analgesic effect is good, long action time, no addiction and toleration, the characteristics that have no side effect.
Another object of the present invention just provides the preparation method of this Chinese medicine composition.
Technical scheme
The object of the present invention is achieved like this:
The present invention treats the Chinese medicine composition of cancer pain, it is characterized in that the preparation raw material (in weight portion) of the contained active component of this Chinese medicine composition is as follows:
Rhizoma Corydalis 471-601 part Radix Notoginseng 257-386 part Myrrha 257-386 part
Rhizoma Curcumae Longae 257-386 part Pseudobulbus Cremastrae Seu Pleiones 257-386 part Rhizoma Curcumae 257-386 part
Borneolum Syntheticum 6-16 part
Preferably, medicine material consumption of the present invention is as follows in weight portion:
Rhizoma Corydalis 493-589 part Radix Notoginseng 278-365 part Myrrha 278-365 part
Rhizoma Curcumae Longae 278-365 part Pseudobulbus Cremastrae Seu Pleiones 278-365 part Rhizoma Curcumae 278-365 part
Borneolum Syntheticum 8-13 part
More preferably, medicine material consumption of the present invention is as follows by weight:
320 parts of 320 parts of Myrrhas of 533 portions of Radix Notoginseng of Rhizoma Corydalis
320 parts of 320 parts of Rhizoma Curcumae of 320 parts of Pseudobulbus Cremastrae Seu Pleioness of Rhizoma Curcumae Longae
11 parts of Borneolum Syntheticums
The source and the effect thereof of the Chinese crude drug that technique scheme is mentioned are as follows:
Rhizoma Corydalis: be the dry tuber of papaveraceae plant corydalis, invigorate blood circulation, promoting the circulation of QI, analgesic effect.
Radix Notoginseng: be the dry root of panax araliaceae plant, have the hemostasis of becoming silted up of loosing, the effect of subduing swelling and relieving pain.
Myrrha: the oleo-gum-resin for Burseraceae shrub or dungarunga myrrh or other bdellium plant skin zone wounds ooze out has promoting blood circulation to relieve pain, the effect of granulation promoting.
Rhizoma Curcumae Longae: be the dry rhizome of zingiberaceous plant Rhizoma Curcumae Longae, can the removing blood stasis circulation of qi promoting, inducing menstruation to relieve menalgia.
Pseudobulbus Cremastrae Seu Pleiones: the dry pseudobulb for the orchid Cremastra appendiculata has the effect of heat-clearing and toxic substances removing, dissipating phlegm and resolving masses.
Rhizoma Curcumae: be the dry rhizome of zingiberaceous plant Rhizoma Curcumae, have the circulation of qi promoting removing blood stasis, removing food stagnancy analgesic effect.
Borneolum Syntheticum:, have the refreshment of having one's ideas straightened out, the effect of clearing away heat to alleviate pain for water white transparency or the crisp crystallization of white translucent lamellar.
The effective ingredient of Chinese medicine composition of the present invention is according to comprising that the method for following each processing step obtains:
(a) Rhizoma Corydalis and Radix Notoginseng powder are broken into coarse powder, with 60-95 volume % ethanol water heating and refluxing extraction three times, each 1-3 hour, merge extractive liquid, also filtered, and relative density is the clear paste of 1.02-1.05 60 ℃ the time with being concentrated into behind the filtrate recycling ethanol;
(b) Myrrha, Rhizoma Curcumae Longae and Rhizoma Curcumae are extracted volatile oil, the aqueous solution after distillation device is in addition collected, and volatile oil is mixed with Borneolum Syntheticum, carries out inclusion with cyclodextrin and water then, stirs 1-3 hour at 60 ℃, and cold preservation is spent the night, and filters, and is ground into fine powder after the cold drying;
(c) above-mentioned medicinal residues and Pseudobulbus Cremastrae Seu Pleiones are decocted with water three times, each 1-3 hour, collecting decoction, filter and the aqueous solution after the distillation in filtrate and the above-mentioned steps (b) merged, be concentrated into that relative density is the clear paste of 1.02-1.05 in the time of 60 ℃, then with above-mentioned steps (a) in the clear paste merging, relative density is the thick paste of 1.20-1.25 when being concentrated into 60 ℃, through drying under reduced pressure, resulting dry thing is crushed to fine powder, again with above-mentioned steps
(b) fine powder of volatile oil inclusion complex is evenly mixed in, makes various dosage forms with pharmaceutically acceptable carrier or excipient then, promptly obtains Chinese medicine composition of the present invention.
The described concentration of alcohol of step in the above-mentioned preparation method (a) is preferably 80%, preferably make a living by weight 6 times of dose of alcoholic solution consumption.
Prescription of the present invention is through the above-mentioned steps preparation, can make various pharmaceutical formulations such as granule, capsule, tablet, pill, oral liquid or the like with pharmaceutically acceptable carrier or excipient composition.Wherein said pharmaceutically acceptable carrier or excipient are selected according to different dosage forms.These used carriers or excipient all are easy to determine for the those of ordinary skill of pharmaceutical field, also are conspicuous.
Beneficial effect
Chinese medicine composition of the present invention has the effect of regulating qi to disperse stagnation, removing obstruction in the collateral to relieve pain, can be used for bloated, the pain heavy treatment at night of costalgia, rib that qi depression to blood stasis causes, to the treatment cancerous pain have that analgesic effect is good, long action time, no addiction and toleration, characteristics such as have no side effect, be suitable for taking for a long time.Medicine of the present invention is easy to take, evident in efficacy, be a kind of medicine of ideal treatment cancer pain.
[specific embodiment]
Below in conjunction with specific embodiment the present invention is elaborated.
Embodiment 1:The preparation of granule of the present invention
Rhizoma Corydalis 533 weight portion Radix Notoginseng 320 weight portion Myrrhas 320 weight portions
Rhizoma Curcumae Longae 320 weight portion Pseudobulbus Cremastrae Seu Pleioness 320 weight portion Rhizoma Curcumae 320 weight portions
Borneolum Syntheticum 11 weight portions
Rhizoma Corydalis and Radix Notoginseng powder are broken into coarse powder, and with 80 volume % ethanol water heating and refluxing extraction three times, each 2 hours, merge extractive liquid, also filtered, and relative density is the clear paste of 1.02-1.05 60 ℃ the time with being concentrated into behind the filtrate recycling ethanol; Myrrha, Rhizoma Curcumae Longae and Rhizoma Curcumae are extracted volatile oil, and the aqueous solution after distillation device is in addition collected, and volatile oil is mixed with Borneolum Syntheticum, carries out inclusion with cyclodextrin and water then, stirs 2 hours at 60 ℃, and cold preservation is spent the night, and filters, and is ground into fine powder after the cold drying; Above-mentioned medicinal residues and Pseudobulbus Cremastrae Seu Pleiones are decocted with water three times, each 2 hours, collecting decoction, filter and with the merging of the aqueous solution after the distillation in filtrate and the above-mentioned steps, be concentrated into that relative density is the clear paste of 1.02-1.05 in the time of 60 ℃, then with above-mentioned steps in the clear paste of Rhizoma Corydalis and Radix Notoginseng merge, relative density is the thick paste of 1.20-1.25 when being concentrated into 60 ℃, through drying under reduced pressure, resulting dry thing is crushed to fine powder, again with above-mentioned steps in Myrrha, the fine powder of the volatile oil inclusion complex of Rhizoma Curcumae Longae and Rhizoma Curcumae is evenly mixed, adds the correctives steviosin and granulates, with the particle drying of preparation, packing.
Below in conjunction with specific embodiment the present invention is elaborated.
Embodiment 2:The preparation of granule of the present invention
Rhizoma Corydalis 471 weight portion Radix Notoginseng 257 weight portion Myrrhas 257 weight portions
Rhizoma Curcumae Longae 257 weight portion Pseudobulbus Cremastrae Seu Pleioness 257 weight portion Rhizoma Curcumae 257 weight portions
Borneolum Syntheticum 6 weight portions
Rhizoma Corydalis and Radix Notoginseng powder are broken into coarse powder, and with 80 volume % ethanol water heating and refluxing extraction three times, each 2 hours, merge extractive liquid, also filtered, and relative density is the clear paste of 1.02-1.05 60 ℃ the time with being concentrated into behind the filtrate recycling ethanol; Myrrha, Rhizoma Curcumae Longae and Rhizoma Curcumae are extracted volatile oil, and the aqueous solution after distillation device is in addition collected, and volatile oil is mixed with Borneolum Syntheticum, carries out inclusion with cyclodextrin and water then, stirs 2 hours at 60 ℃, and cold preservation is spent the night, and filters, and is ground into fine powder after the cold drying; Above-mentioned medicinal residues and Pseudobulbus Cremastrae Seu Pleiones are decocted with water three times, each 2 hours, collecting decoction, filter and with the merging of the aqueous solution after the distillation in filtrate and the above-mentioned steps, be concentrated into that relative density is the clear paste of 1.02-1.05 in the time of 60 ℃, then with above-mentioned steps in the clear paste of Rhizoma Corydalis and Radix Notoginseng merge, relative density is the thick paste of 1.20-1.25 when being concentrated into 60 ℃, through drying under reduced pressure, resulting dry thing is crushed to fine powder, again with above-mentioned steps in Myrrha, the fine powder of the volatile oil inclusion complex of Rhizoma Curcumae Longae and Rhizoma Curcumae is evenly mixed, adds the correctives steviosin and granulates, with the particle drying of preparation, packing.
Below in conjunction with specific embodiment the present invention is elaborated.
Embodiment 3:The preparation of granule of the present invention
Rhizoma Corydalis 601 weight portion Radix Notoginseng 386 weight portion Myrrhas 386 weight portions
Rhizoma Curcumae Longae 386 weight portion Pseudobulbus Cremastrae Seu Pleioness 386 weight portion Rhizoma Curcumae 386 weight portions
Borneolum Syntheticum 16 weight portions
Rhizoma Corydalis and Radix Notoginseng powder are broken into coarse powder, and with 80 volume % ethanol water heating and refluxing extraction three times, each 2 hours, merge extractive liquid, also filtered, and relative density is the clear paste of 1.02-1.05 60 ℃ the time with being concentrated into behind the filtrate recycling ethanol; Myrrha, Rhizoma Curcumae Longae and Rhizoma Curcumae are extracted volatile oil, and the aqueous solution after distillation device is in addition collected, and volatile oil is mixed with Borneolum Syntheticum, carries out inclusion with cyclodextrin and water then, stirs 2 hours at 60 ℃, and cold preservation is spent the night, and filters, and is ground into fine powder after the cold drying; Above-mentioned medicinal residues and Pseudobulbus Cremastrae Seu Pleiones are decocted with water three times, each 2 hours, collecting decoction, filter and with the merging of the aqueous solution after the distillation in filtrate and the above-mentioned steps, be concentrated into that relative density is the clear paste of 1.02-1.05 in the time of 60 ℃, then with above-mentioned steps in the clear paste of Rhizoma Corydalis and Radix Notoginseng merge, relative density is the thick paste of 1.20-1.25 when being concentrated into 60 ℃, through drying under reduced pressure, resulting dry thing is crushed to fine powder, again with above-mentioned steps in Myrrha, the fine powder of the volatile oil inclusion complex of Rhizoma Curcumae Longae and Rhizoma Curcumae is evenly mixed, adds the correctives steviosin and granulates, with the particle drying of preparation, packing.
Embodiment 4:The preparation of capsule of the present invention
Rhizoma Corydalis 533 weight portion Radix Notoginseng 320 weight portion Myrrhas 320 weight portions
Rhizoma Curcumae Longae 320 weight portion Pseudobulbus Cremastrae Seu Pleioness 320 weight portion Rhizoma Curcumae 320 weight portions
Borneolum Syntheticum 11 weight portions
Rhizoma Corydalis and Radix Notoginseng powder are broken into coarse powder, and with 80 volume % ethanol water heating and refluxing extraction three times, each 2 hours, merge extractive liquid, also filtered, and relative density is the clear paste of 1.02-1.05 60 ℃ the time with being concentrated into behind the filtrate recycling ethanol; Myrrha, Rhizoma Curcumae Longae and Rhizoma Curcumae are extracted volatile oil, and the aqueous solution after distillation device is in addition collected, and volatile oil is mixed with Borneolum Syntheticum, carries out inclusion with cyclodextrin and water then, stirs 2 hours at 60 ℃, and cold preservation is spent the night, and filters, and is ground into fine powder after the cold drying; Above-mentioned medicinal residues and Pseudobulbus Cremastrae Seu Pleiones are decocted with water three times, each 2 hours, collecting decoction, filter and with the merging of the aqueous solution after the distillation in filtrate and the above-mentioned steps, be concentrated into that relative density is the clear paste of 1.02-1.05 in the time of 60 ℃, then with above-mentioned steps in the clear paste of Rhizoma Corydalis and Radix Notoginseng merge, relative density is the thick paste of 1.20-1.25 when being concentrated into 60 ℃, through drying under reduced pressure, resulting dry thing is crushed to fine powder, again with above-mentioned steps in the fine powder of volatile oil inclusion complex of Myrrha, Rhizoma Curcumae Longae and Rhizoma Curcumae evenly mixed, incapsulate then.
Embodiment 5:The preparation of tablet of the present invention
Rhizoma Corydalis 533 weight portion Radix Notoginseng 320 weight portion Myrrhas 320 weight portions
Rhizoma Curcumae Longae 320 weight portion Pseudobulbus Cremastrae Seu Pleioness 320 weight portion Rhizoma Curcumae 320 weight portions
Borneolum Syntheticum 11 weight portions
Rhizoma Corydalis and Radix Notoginseng powder are broken into coarse powder, and with 80 volume % ethanol water heating and refluxing extraction three times, each 2 hours, merge extractive liquid, also filtered, and relative density is the clear paste of 1.02-1.05 60 ℃ the time with being concentrated into behind the filtrate recycling ethanol; Myrrha, Rhizoma Curcumae Longae and Rhizoma Curcumae are extracted volatile oil, and the aqueous solution after distillation device is in addition collected, and volatile oil is mixed with Borneolum Syntheticum, carries out inclusion with cyclodextrin and water then, stirs 2 hours at 60 ℃, and cold preservation is spent the night, and filters, and is ground into fine powder after the cold drying; Above-mentioned medicinal residues and Pseudobulbus Cremastrae Seu Pleiones are decocted with water three times, each 2 hours, collecting decoction, filter and with the merging of the aqueous solution after the distillation in filtrate and the above-mentioned steps, be concentrated into that relative density is the clear paste of 1.02-1.05 in the time of 60 ℃, then with above-mentioned steps in the clear paste of Rhizoma Corydalis and Radix Notoginseng merge, relative density is the thick paste of 1.20-1.25 when being concentrated into 60 ℃, through drying under reduced pressure, resulting dry thing is crushed to fine powder, again with above-mentioned steps in Myrrha, the fine powder of the volatile oil inclusion complex of Rhizoma Curcumae Longae and Rhizoma Curcumae is mixed evenly, makes wet granular, tabletting with preparation tablet excipient commonly used such as starch etc. then.
Embodiment 6:The preparation of pill of the present invention
Rhizoma Corydalis 533 weight portion Radix Notoginseng 320 weight portion Myrrhas 320 weight portions
Rhizoma Curcumae Longae 320 weight portion Pseudobulbus Cremastrae Seu Pleioness 320 weight portion Rhizoma Curcumae 320 weight portions
Borneolum Syntheticum 11 weight portions
Rhizoma Corydalis and Radix Notoginseng powder are broken into coarse powder, and with 80 volume % ethanol water heating and refluxing extraction three times, each 2 hours, merge extractive liquid, also filtered, and relative density is the clear paste of 1.02-1.05 60 ℃ the time with being concentrated into behind the filtrate recycling ethanol; Myrrha, Rhizoma Curcumae Longae and Rhizoma Curcumae are extracted volatile oil, and the aqueous solution after distillation device is in addition collected, and volatile oil is mixed with Borneolum Syntheticum, carries out inclusion with cyclodextrin and water then, stirs 2 hours at 60 ℃, and cold preservation is spent the night, and filters, and is ground into fine powder after the cold drying; Above-mentioned medicinal residues and Pseudobulbus Cremastrae Seu Pleiones are decocted with water three times, each 2 hours, collecting decoction, filter and with the merging of the aqueous solution after the distillation in filtrate and the above-mentioned steps, be concentrated into that relative density is the clear paste of 1.02-1.05 in the time of 60 ℃, then with above-mentioned steps in the clear paste of Rhizoma Corydalis and Radix Notoginseng merge, relative density is the thick paste of 1.20-1.25 when being concentrated into 60 ℃, through drying under reduced pressure, resulting dry thing is crushed to fine powder, again with above-mentioned steps in Myrrha, the fine powder of the volatile oil inclusion complex of Rhizoma Curcumae Longae and Rhizoma Curcumae is evenly mixed, adds refined honey then and makes small honey pill or big honeyed pills.
Embodiment 7:Oral liquid of the present invention
Rhizoma Corydalis 533 weight portion Radix Notoginseng 320 weight portion Myrrhas 320 weight portions
Rhizoma Curcumae Longae 320 weight portion Pseudobulbus Cremastrae Seu Pleioness 320 weight portion Rhizoma Curcumae 320 weight portions
Borneolum Syntheticum 11 weight portions
Rhizoma Corydalis and Radix Notoginseng powder are broken into coarse powder, and with 80 volume % ethanol water heating and refluxing extraction three times, each 2 hours, merge extractive liquid, also filtered, and relative density is the clear paste of 1.02-1.05 60 ℃ the time with being concentrated into behind the filtrate recycling ethanol; Myrrha, Rhizoma Curcumae Longae and Rhizoma Curcumae are extracted volatile oil, and the aqueous solution after distillation device is in addition collected, and volatile oil is mixed with Borneolum Syntheticum, carries out inclusion with cyclodextrin and water then, stirs 2 hours at 60 ℃, and cold preservation is spent the night, and filters, and is ground into fine powder after the cold drying; Above-mentioned medicinal residues and Pseudobulbus Cremastrae Seu Pleiones are decocted with water three times, each 2 hours, collecting decoction, filter and with the merging of the aqueous solution after the distillation in filtrate and the above-mentioned steps, be concentrated into that relative density is the clear paste of 1.02-1.05 in the time of 60 ℃, then with above-mentioned steps in the clear paste of Rhizoma Corydalis and Radix Notoginseng merge, relative density is the thick paste of 1.20-1.25 when being concentrated into 60 ℃, through drying under reduced pressure, resulting dry thing is crushed to fine powder, again with above-mentioned steps in Myrrha, the fine powder of the volatile oil inclusion complex of Rhizoma Curcumae Longae and Rhizoma Curcumae is evenly mixed, adds correctives Mel and diluent water then and makes oral liquid.
Below by testing the effect of further Chinese medicine composition.
Experimental example 1:The clinical trial of Chinese medicine composition of the present invention
The case choice criteria:
1, checks, is diagnosed as cancer person through X line, CT, B ultrasonic, blood biochemical, seroimmunity, MRI,, need Drug therapy person with pain in conjunction with medical history, clinical symptoms and sign.
2, Chinese medical discrimination is a qi depression to blood stasis disease, localized pain, and pain night is heavy, and is uncomfortable in chest with abdominal distention, the kind sigh, dark tongue quality or ecchymosis is arranged, stringy and thready pulse or weak pulse.
3, the age is at 18-65 between year.
4, estimate that existence is person more than 3 months.
5, stop using put, chemotherapy is more than one week, pain does not have alleviation person.
Get rid of the case standard:
1, non-above-mentioned cancer patient.
2, with severe cardiac, liver, renal insufficiency person.
3, treatment was used other analgesic and analgesic person in preceding 24 hours.
4, cognitive disorder or disturbance of consciousness person are arranged.
5, just carrying out the chemicotherapy person.
Test method:
1, adopts random packet, counter point.
2, verify routine number: 60 examples are organized in treatment, matched group 60 examples.
3, treatment group medication: product granule of the present invention, oral, each 10 grams, every day 3 times.
4, the course of treatment: 7 days, and tried the patient during the clinical verification and can not adopt other relevant treatment simultaneously.
5, medication did not have alleviation person as pain in 3 days, invalid case.
Curative effect index:
1, observation index: to the influence of blood pressure, breathing, heart rate; To neural influence; Gastrointestinal function is influenced; Anaphylaxis.
2, the observation of pain: mild pain; Moderate pain; Severe pain.
3, tcm symptom is observed: abdominal distention; Pain is heavy night; Breast is vexed; The kind sigh;
Curative effect determinate standard:
1, clinic control: treat the back symptom and disappear substantially.
2, produce effects: treat the back symptom and obviously improve.
3, effective: as to treat the back doing well,improving.
4, invalid: clinical symptoms no change or do not reach effective standard.
Result of the test: the every data to clinical trial are carried out statistical procedures, general enumeration data X 2 test, and measurement data is checked with t, and the level data data is analyzed with Ridit.Concrete data see the following form.
Table 1 cancer pain remission effect synopsis
| The example number | Transference cure | Manifest alleviation | The slight alleviation | Do not alleviate | Remission rate | |
| Granule of the present invention | ????61 | ????7 | ????15 | ????24 | ????15 | ????75.41％ |
Above data show that Chinese medicine of the present invention is 75.41% to terminal cancer case syndrome remission rate, and disappearance rate is that 11.48% alleviation degree is good, the remission rate height.
Claims (6)
1. Chinese medicine composition that is used for the treatment of cancer pain, it is made up of effective ingredient or effective ingredient and pharmaceutically acceptable carrier, it is characterized in that its contained effective ingredient made by following bulk drugs:
Rhizoma Corydalis 471-601 weight portion Radix Notoginseng 257-386 weight portion
Myrrha 257-386 weight portion Rhizoma Curcumae Longae 257-386 weight portion
Pseudobulbus Cremastrae Seu Pleiones 257-386 weight portion Rhizoma Curcumae 257-386 weight portion
Borneolum Syntheticum 6-16 weight portion.
2. according to the Chinese medicine composition described in the claim 1, be characterised in that preparation raw materials of effective components medicine and consumption thereof are:
Rhizoma Corydalis 493-589 weight portion Radix Notoginseng 278-365 weight portion
Myrrha 278-365 weight portion Rhizoma Curcumae Longae 278-365 weight portion
Pseudobulbus Cremastrae Seu Pleiones 278-365 weight portion Rhizoma Curcumae 278-365 weight portion
Borneolum Syntheticum 8-13 weight portion.
3. according to the Chinese medicine composition described in the claim 1, wherein prepare raw materials of effective components medicine and consumption thereof and be:
Rhizoma Corydalis 533 weight portion Radix Notoginseng 320 weight portion Myrrhas 320 weight portions
Rhizoma Curcumae Longae 320 weight portion Pseudobulbus Cremastrae Seu Pleioness 320 weight portion Rhizoma Curcumae 320 weight portions
Borneolum Syntheticum 11 weight portions.
4. according to any one described Chinese medicine composition among the claim 1-3, it is granule, capsule, tablet, pill or oral liquid.
5. according to the preparation method of any one described Chinese medicine composition among the claim 1-4, it comprises:
(a) Rhizoma Corydalis and Radix Notoginseng powder are broken into coarse powder, with 60-95 volume % ethanol water heating and refluxing extraction three times, each 1-3 hour, merge extractive liquid, also filtered, and relative density is the clear paste of 1.02-1.05 60 ℃ the time with being concentrated into behind the filtrate recycling ethanol;
(b) Myrrha, Rhizoma Curcumae Longae and Rhizoma Curcumae are extracted volatile oil, the aqueous solution after distillation device is in addition collected, and volatile oil is mixed with Borneolum Syntheticum, carries out inclusion with cyclodextrin and water then, stirs 1-3 hour at 60 ℃, and cold preservation is spent the night, and filters, and is ground into fine powder after the cold drying;
(c) above-mentioned medicinal residues and Pseudobulbus Cremastrae Seu Pleiones are decocted with water three times, each 1-3 hour, collecting decoction, filter and the aqueous solution after the distillation in filtrate and the above-mentioned steps (b) merged, be concentrated into that relative density is the clear paste of 1.02-1.05 in the time of 60 ℃, then with above-mentioned steps (a) in the clear paste merging, relative density is the thick paste of 1.20-1.25 when being concentrated into 60 ℃, through drying under reduced pressure, resulting dry thing is crushed to fine powder, again with above-mentioned steps
(b) fine powder of volatile oil inclusion complex is evenly mixed in, makes various dosage forms with pharmaceutically acceptable carrier or excipient then, promptly obtains Chinese medicine composition of the present invention.
6. preparation method according to claim 5 is characterized in that the described concentration of alcohol of step (a) is 80%, make a living by weight 6 times of dose of alcoholic solution consumption.
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| CNB200310103525XA CN1304045C (en) | 2003-11-06 | 2003-11-06 | Arthralgia removing pills and their preparation |
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| CNB200310103525XA CN1304045C (en) | 2003-11-06 | 2003-11-06 | Arthralgia removing pills and their preparation |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104399011A (en) * | 2014-12-16 | 2015-03-11 | 孔馨苑 | Traditional Chinese medicine combination for treating esophageal cancer pain and preparation method thereof |
| CN107335011A (en) * | 2017-07-14 | 2017-11-10 | 烟台市中医医院 | Treat the external application Chinese medicine compound preparation of cancer pain |
| CN115381912A (en) * | 2022-09-23 | 2022-11-25 | 湖南省中医药研究院附属医院 | External traditional Chinese medicine compound preparation for reducing cancer pain and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1042799C (en) * | 1993-03-03 | 1999-04-07 | 高贵 | Blood-activating analgetic plaster for tumour |
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2003
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104399011A (en) * | 2014-12-16 | 2015-03-11 | 孔馨苑 | Traditional Chinese medicine combination for treating esophageal cancer pain and preparation method thereof |
| CN107335011A (en) * | 2017-07-14 | 2017-11-10 | 烟台市中医医院 | Treat the external application Chinese medicine compound preparation of cancer pain |
| CN107335011B (en) * | 2017-07-14 | 2020-10-23 | 侯爱画 | External traditional Chinese medicine compound preparation for treating cancer pain |
| CN115381912A (en) * | 2022-09-23 | 2022-11-25 | 湖南省中医药研究院附属医院 | External traditional Chinese medicine compound preparation for reducing cancer pain and preparation method thereof |
| CN115381912B (en) * | 2022-09-23 | 2024-02-13 | 湖南省中医药研究院 | External traditional Chinese medicine compound preparation for reducing cancer pain and preparation method thereof |
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| CN1304045C (en) | 2007-03-14 |
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