CN1611525A - 生物可降解材料的制备方法 - Google Patents
生物可降解材料的制备方法 Download PDFInfo
- Publication number
- CN1611525A CN1611525A CN 200310110794 CN200310110794A CN1611525A CN 1611525 A CN1611525 A CN 1611525A CN 200310110794 CN200310110794 CN 200310110794 CN 200310110794 A CN200310110794 A CN 200310110794A CN 1611525 A CN1611525 A CN 1611525A
- Authority
- CN
- China
- Prior art keywords
- lactic acid
- film
- polyethyleneglycol
- biodegradable
- biodegradable material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000463 material Substances 0.000 title claims abstract description 26
- 238000000034 method Methods 0.000 title claims description 3
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims abstract description 106
- 235000014655 lactic acid Nutrition 0.000 claims abstract description 53
- 239000004310 lactic acid Substances 0.000 claims abstract description 53
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 40
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 40
- 238000012662 bulk polymerization Methods 0.000 claims abstract description 3
- 238000006243 chemical reaction Methods 0.000 claims abstract description 3
- 238000007334 copolymerization reaction Methods 0.000 claims abstract description 3
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 44
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 26
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 24
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical group CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 22
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 22
- 239000012046 mixed solvent Substances 0.000 claims description 22
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 22
- 238000001291 vacuum drying Methods 0.000 claims description 22
- 230000000181 anti-adherent effect Effects 0.000 claims description 20
- -1 polyoxyethylene Polymers 0.000 claims description 17
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 13
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 13
- 238000009998 heat setting Methods 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 claims description 11
- 230000015556 catabolic process Effects 0.000 abstract description 6
- 238000006731 degradation reaction Methods 0.000 abstract description 6
- 239000000470 constituent Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000012528 membrane Substances 0.000 description 4
- 229920000747 poly(lactic acid) Polymers 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 3
- 229920001661 Chitosan Polymers 0.000 description 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 229920002674 hyaluronan Polymers 0.000 description 2
- 229960003160 hyaluronic acid Drugs 0.000 description 2
- 239000004626 polylactic acid Substances 0.000 description 2
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N EtOH Substances CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 208000031737 Tissue Adhesions Diseases 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 239000002510 pyrogen Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
- Biological Depolymerization Polymers (AREA)
Abstract
Description
Claims (3)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2003101107949A CN1305928C (zh) | 2003-10-27 | 2003-10-27 | 生物可降解材料的制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2003101107949A CN1305928C (zh) | 2003-10-27 | 2003-10-27 | 生物可降解材料的制备方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1611525A true CN1611525A (zh) | 2005-05-04 |
| CN1305928C CN1305928C (zh) | 2007-03-21 |
Family
ID=34759235
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2003101107949A Expired - Lifetime CN1305928C (zh) | 2003-10-27 | 2003-10-27 | 生物可降解材料的制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1305928C (zh) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100445313C (zh) * | 2007-04-24 | 2008-12-24 | 上海同杰良生物材料有限公司 | 一种聚乳酸/聚醚二元醇共聚物的制备方法 |
| CN102107018A (zh) * | 2011-01-11 | 2011-06-29 | 上海鼎华医械有限责任公司 | 术后防粘连膜及其用途 |
| CN103495211A (zh) * | 2013-10-15 | 2014-01-08 | 山东赛克赛斯药业科技有限公司 | 用于心脏手术的可吸收防粘连膜及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01163135A (ja) * | 1987-12-18 | 1989-06-27 | Taki Chem Co Ltd | 徐放性基剤の製造方法 |
| EP0669358B1 (en) * | 1993-09-09 | 2003-11-19 | Kanebo Ltd. | Biodegradable copolyester, molding produced therefrom, and process for producing the molding |
| CN1049905C (zh) * | 1994-05-03 | 2000-03-01 | 中国科学院成都有机化学研究所 | 内酯或交酯与聚醚二醇的共聚方法 |
| CN1132758A (zh) * | 1995-04-06 | 1996-10-09 | 中国科学院成都有机化学研究所 | 一种高分子微球及其制法和用途 |
-
2003
- 2003-10-27 CN CNB2003101107949A patent/CN1305928C/zh not_active Expired - Lifetime
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100445313C (zh) * | 2007-04-24 | 2008-12-24 | 上海同杰良生物材料有限公司 | 一种聚乳酸/聚醚二元醇共聚物的制备方法 |
| CN102107018A (zh) * | 2011-01-11 | 2011-06-29 | 上海鼎华医械有限责任公司 | 术后防粘连膜及其用途 |
| CN103495211A (zh) * | 2013-10-15 | 2014-01-08 | 山东赛克赛斯药业科技有限公司 | 用于心脏手术的可吸收防粘连膜及其制备方法 |
| CN103495211B (zh) * | 2013-10-15 | 2016-03-23 | 山东赛克赛斯药业科技有限公司 | 用于心脏手术的可吸收防粘连膜及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1305928C (zh) | 2007-03-21 |
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| C06 | Publication | ||
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| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: SHANGHAI ZHIYUAN BIOLOGY MEDICAL DEVICES CO., LTD Free format text: FORMER OWNER: TUOTAI MEDICAL SCI. + TECH. DEV. CO., LTD., CHENGDU Effective date: 20051209 |
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Effective date of registration: 20051209 Address after: 200060 room 9, No. 1283, Lane 2306, Shanghai, North Shaanxi Road Applicant after: Shanghai Zhiyuan biological medical instrument Co.,Ltd. Address before: 610043 Sichuan city of Chengdu province Wuhou District Cuoqiao dragon Jinyuan three District No. 8-3-1 Applicant before: CHENGDU TUOTAI MEDICINE SCI. & TECH. DEV. Co.,Ltd. |
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Owner name: ZHU XIAOMING Free format text: FORMER OWNER: QIDONG ZHIYUAN BIOLOGY SCIENCE CO., LTD. Effective date: 20080104 |
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Effective date of registration: 20080104 Address after: Chengdu City, Sichuan Province, northwest of the temple street lamp No. 3 Patentee after: Zhu Xiaoming Address before: Jiangsu Province, Qidong City Department of Yuelong road Dragon Town Industrial Park No. 2 Patentee before: Tuotai Pharmaceutical Sci & Tech Development Co.,Ltd. Chengdu |
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Owner name: GUANGZHOU HONGJIAN BIO-MEDICAL PRODUCTS AND TECHNO Free format text: FORMER OWNER: ZHU XIAOMING Effective date: 20120228 |
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Free format text: CORRECT: ADDRESS; FROM: 610041 CHENGDU, SICHUAN PROVINCE TO: 510663 GUANGZHOU, GUANGDONG PROVINCE |
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Effective date of registration: 20120228 Address after: 510663 Guangzhou hi tech Industrial Development Zone, Guangdong Province, No. 17 Xiang Shan Road, B6-1 Patentee after: GUANGZHOU HONG JIAN BIO-MEDICAL PRODUCTS AND TECHNOLOGY Co.,Ltd. Address before: Chengdu City, Sichuan Province, northwest of the temple street lamp 610041 No. 3 Patentee before: Zhu Xiaoming |
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Owner name: CHENGDU NANDING MEDICAL MATERIAL CO., LTD. Free format text: FORMER OWNER: GUANGZHOU HONGJIAN BIO-MEDICAL PRODUCTS AND TECHNOLOGY CO., LTD. Effective date: 20130118 |
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Free format text: CORRECT: ADDRESS; FROM: 510663 GUANGZHOU, GUANGDONG PROVINCE TO: 610200 CHENGDU, SICHUAN PROVINCE |
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Effective date of registration: 20130118 Address after: 610200, No. six, section 59, the Yellow River Road, Shuangliu industrial port, Shuangliu, Sichuan, Chengdu Patentee after: CHENGDU NANDING MEDICAL MATERIAL Co.,Ltd. Address before: 510663 Guangzhou hi tech Industrial Development Zone, Guangdong Province, No. 17 Xiang Shan Road, B6-1 Patentee before: GUANGZHOU HONG JIAN BIO-MEDICAL PRODUCTS AND TECHNOLOGY Co.,Ltd. |
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| EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20050504 Assignee: GUANGZHOU HONG JIAN BIO-MEDICAL PRODUCTS AND TECHNOLOGY Co.,Ltd. Assignor: CHENGDU NANDING MEDICAL MATERIAL Co.,Ltd. Contract record no.: 2018510000006 Denomination of invention: Method for preparing biodegradable material Granted publication date: 20070321 License type: Exclusive License Record date: 20180112 |
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Granted publication date: 20070321 |
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