CN1602902A - Medicine for treating angina and preparation technology thereof - Google Patents

Abstract

The invention discloses the composition of a Chinese patent drug for curing coronarism and a production technique of preparing the Chinese patent drug, and the effective components of the Chinese patent drug include danshen, ligusticum chuanxiong, safflower, the tuber of multiflower knotweed, radix polygonati officinalis, fuling, dalbergia odorifera, Schisandra chinensis, Asarum sieboldii, artificial musk, and borneol and its preparing technique: taking dalbergia wood, Schisandra chinensis, and Asarum sieboldii, adding in water and soaking them, and extracting and reserving naphtha; taking danshen, ligusticum chuanxiong, and safflower, adding in alcohol to extract, combining the extracts and then filtering; combining the residues of danshen, ligusticum chuanxiong and safflower with the tuber of multiflower knotweed, radix polygonati officinalis, fuling, etc, adding in water and decocting, combining the decoctions, placing still, taking supernatant to combine with the water extract of dalbergia wood, Schisandra chinensis, and Asarum sieboldii, adding in alcohol, stirring and filtering and then evaporate-concentrating, combining with alcohol extraction concentrate of danshen, ligusticum chuanxiong and safflower, adding in a proper amount of dextrin and blending uniformly and obtaining dry cream; mixing the dry cream with artificial musk and borneol and then crushing the mixture, adding in the above naphtha, mixing uniformly, dry-making into granules, and canning and obtaining it; the invention can quickly relieve coronarism, obviously improve myocardial ischemia, improve cardiogram and achieve the purpose of treating both principal and secondary aspect of disease.

Description

Anginal medicine of a kind of treatment and preparation technology thereof

Technical field

The present invention relates to a kind of production technology that anginal Chinese Traditional Medicines become to be grouped into and to prepare these Chinese Traditional Medicines for the treatment of.

Background technology

From the global human angle, cardiovascular disease belongs to one of disease that sickness rate is the highest, mortality rate is also the highest.According to global dead population 5,200 ten thousand statistics of WHO tissue in 1996 announcement, the population of wherein dying from coronary heart disease reaches 7,200,000, accounts for 13.85% of total dead population, occupies first of the noninfectious.Along with improving constantly of people's living standard, the great variety that causes dietary structure and ecological environment, the M ﹠ M of coronary heart disease one this rich man's disease is all in rising trend, and, the cause of coronary heart disease age also is the development that becomes younger, and therefore prevents and treats the drug research of coronary heart disease and is paid close attention to by national governments and medical worker with exploitation always.Although the medicine of new treatment coronary heart disease is constantly released, adopt Chinese patent medicine material component treatment coronary heart disease not see definite report.

Summary of the invention utilization Chinese crude drug has

The objective of the invention is to: medical angle therefrom, utilization Chinese crude drug effective ingredient, allevating angina pectoris obviously improves myocardial ischemia rapidly, improves electrocardiogram, reaches treating both the principal and secondary aspects of a disease.

Technical scheme of the present invention is achieved in that the anginal medicine of a kind of treatment, its effective ingredient is: Radix Salviae Miltiorrhizae 100-1000 gram, Rhizoma Chuanxiong 100-500 gram, Flos Carthami 100-500 gram, Radix Polygoni Multiflori 100-1000 gram, Rhizoma Polygonati Odorati 100-1000 gram, Poria 100-500 gram, Lignum Dalbergiae Odoriferae 100-500 gram, Fructus Schisandrae Chinensis 100-500 gram, Herba Asari 10-500 gram, artificial Moschus 0.001-10 gram, Borneolum Syntheticum 0.001-10 gram can make the 800-6000 gram.

The preparation technology who treats anginal medicine is:

A, get effective ingredient Lignum Dalbergiae Odoriferae, Fructus Schisandrae Chinensis, Herba Asari, add 5 times of water gagings and soaked 12 hours, extracted volatile oil 8 hours, get volatile oil and water extract with oil extractor, standby;

B, get effective ingredient Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Flos Carthami, add 5 times of amount 95% ethanol extraction secondaries, each 1 hour, merge extractive liquid, filtered, and filtrate is 1.27-1.30 when being evaporated to relative density at 50 ℃ below 60 ℃;

C, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, the medicinal residues of Flos Carthami and effective ingredient Radix Polygoni Multiflori, Rhizoma Polygonati Odorati, merging such as Poria, add 5 times of water gagings and decoct secondary, each 1 hour, collecting decoction, leave standstill, get supernatant, with Lignum Dalbergiae Odoriferae, Fructus Schisandrae Chinensis, the water extract of Herba Asari merges, and being evaporated to relative density is 1.06-1.09 in the time of 60 ℃, add 70%-95% ethanol, stir, standing over night is filtered, it is 1.28-1.32 in the time of 60 ℃ that filtrate decompression is concentrated into relative density, go to evaporation and concentration, to relative density be 1.38-1.40 60 ℃ the time, with Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, the alcohol extraction concentrated solution of Flos Carthami merges, add an amount of dextrin, mix thoroughly, drying under reduced pressure below 60 ℃ gets dry extract;

D, dried cream and artificial Moschus, the Borneolum Syntheticum of gained mixed, add an amount of lactose and pulverize, cross 80 mesh sieves, add volatile oil such as above-mentioned Lignum Dalbergiae Odoriferae again, mixing, dry method is made granule, and is promptly canned.Every bag of content 6 grams are equivalent to crude drug 19.47 grams.

Chinese Traditional Medicines prescription of the present invention is rigorous, terse, can improve disease symptoms, allevating angina pectoris fast.

Main pharmacodynamics research: duodenum obtains medicine 2.5 grams of the present invention, 5.0 grams or 10.0 gram crude drug/kilograms, but dosage obviously improves the big ischemic electrocardiogram of coronary ligation with relying on, and the ST reduction is along with increase onset time of dosage also shifts to an earlier date; Duodenum obtains medicine of the present invention can obviously reduce myocardial infarction area; Medicine of the present invention has slight momentary reduction effect to anaesthetizing big blood pressure, can reduce ventricle and do work index, and total peripheral resistance is had the trend of reduction, and hemodynamics is shown favorable influence; Can reduce the uptake ratio (P＜0.05) of cardiac muscle to oxygen; Myocardial ischemia to the coronary ligation rat shows good preventing and therapeutical effect; Medicine 12.5 grams of the present invention, 25.0 gram crude drug/kilograms can also reduce the ratio of serum TG content and serum TC/HDL-C; Continuous oral is irritated stomach medicine 25.0 gram crude drug/kilograms of the present invention after 8 weeks, formation to experimental atherosclerosis Carnis Coturnicis japonicae endarterium speckle has the obvious suppression effect, Carnis Coturnicis japonicae tremulous pulse serum content HDL-C and reduction TC/HDL-C ratio 6.3 gram, 12.5 grams, 25.0 gram crude drug/kilograms all can raise, 12.5 gram crude drug/kilogram can reduce serum LDL-C content simultaneously, 25.0 gram crude drug/kilograms can reduce serum total cholesterol content.

Acute toxicity testing: oral maximum tolerated dose is 221.8 gram crude drug/kilograms, is equivalent to 228.6 times of clinical dosage.

Long term toxicity test: medicine of the present invention 30.0 grams, 60.0 gram crude drug/kg/day were in rat oral administration gavage 6 days weekly, and continuous 3 months, the result compared with matched group, and high dose group had the reduction effect to the female rats body weight after two months; Female rats serum BUN content raise in normal range after three months; The rat liver index of two dosage groups increases, drug withdrawal after one month full recovery normal.All other are checked indexs and pathologic finding there are no significant and change.30.0 gram crude drug/kg/day is a safe dose, 60.0 gram crude drug/kg/day are 60 times that high dose group is equivalent to clinical dosage.

The specific embodiment

Embodiment one

A. get effective ingredient Lignum Dalbergiae Odoriferae 100 grams, Fructus Schisandrae Chinensis 100 grams, Herba Asari 10 grams, add 1020 ml waters and soaked 12 hours, extracted volatile oil 8 hours, get volatile oil and water extract with oil extractor, standby;

B, get effective ingredient Radix Salviae Miltiorrhizae 1000 gram, Rhizoma Chuanxiong 500 grams, Flos Carthami 500 grams, add 10000 milliliter of 95% ethanol extraction secondary, each 1 hour, merge extractive liquid, filtered, and filtrate is 1.27-1.30 when being evaporated to relative density at 50 ℃ below 60 ℃;

C, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, about 500 grams of the medicinal residues of Flos Carthami and effective ingredient Radix Polygoni Multiflori 100 grams, Rhizoma Polygonati Odorati 1000 grams, merging such as Poria 100 grams, add 8500 ml waters and decoct secondary, each 1 hour, collecting decoction, leave standstill, get supernatant, with Lignum Dalbergiae Odoriferae, Fructus Schisandrae Chinensis, the water extract of Herba Asari merges, and being evaporated to relative density is 1.06-1.09 in the time of 60 ℃, add 70%-95% ethanol, stir, standing over night is filtered, it is 1.28-1.32 in the time of 60 ℃ that filtrate decompression is concentrated into relative density, go to evaporation and concentration, to relative density be 1.38-1.40 60 ℃ the time, with Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, the alcohol extraction concentrated solution of Flos Carthami merges, add an amount of dextrin, mix thoroughly, drying under reduced pressure below 60 ℃ gets dry extract;

D, the dried cream of gained is mixed with artificial Moschus's 10 grams, Borneolum Syntheticum 10 grams, adds an amount of lactose pulverizing, mistake 80 mesh sieves add volatile oil such as above-mentioned Lignum Dalbergiae Odoriferae again, mixing, and dry method is made granule, and is promptly canned.Every bag of content 6 grams are equivalent to crude drug 19.47 grams.

Embodiment two

A, get effective ingredient Lignum Dalbergiae Odoriferae 500 gram, Fructus Schisandrae Chinensis 500 grams, Herba Asari 500 grams, add 7500 ml waters and soaked 12 hours, extracted volatile oil 8 hours, get volatile oil and water extract with oil extractor, standby;

B, get effective ingredient Radix Salviae Miltiorrhizae 100 gram, Rhizoma Chuanxiong 100 grams, Flos Carthami 100 grams, add 1500 milliliter of 95% ethanol extraction secondary, each 1 hour, merge extractive liquid, filtered, and filtrate is 1.27-1.30 when being evaporated to relative density at 50 ℃ below 60 ℃;

C, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, about 75 grams of the medicinal residues of Flos Carthami and effective ingredient Radix Polygoni Multiflori 1000 grams, Rhizoma Polygonati Odorati 100 grams, merging such as Poria 500 grams, add 8375 ml waters and decoct secondary, each 1 hour, collecting decoction, leave standstill, get supernatant, with Lignum Dalbergiae Odoriferae, Fructus Schisandrae Chinensis, the water extract of Herba Asari merges, and being evaporated to relative density is 1.06-1.09 in the time of 60 ℃, add 70%-95% ethanol, stir, standing over night is filtered, it is 1.28-1.32 in the time of 60 ℃ that filtrate decompression is concentrated into relative density, go to evaporation and concentration, to relative density be 1.38-1.40 60 ℃ the time, with Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, the alcohol extraction concentrated solution of Flos Carthami merges, add an amount of dextrin, mix thoroughly, drying under reduced pressure below 60 ℃ gets dry extract;

D, the dried cream of gained is mixed with artificial Moschus's 0.001 gram, Borneolum Syntheticum 0.001 gram, adds an amount of lactose pulverizing, mistake 80 mesh sieves add volatile oil such as above-mentioned Lignum Dalbergiae Odoriferae again, mixing, and dry method is made granule, and is promptly canned.Every bag of content 6 grams are equivalent to crude drug 19.47 grams.

Embodiment three

A, get effective ingredient Lignum Dalbergiae Odoriferae 300 gram, Fructus Schisandrae Chinensis 300 grams, Herba Asari 300 grams, add 4500 ml waters and soaked 12 hours, extracted volatile oil 8 hours, get volatile oil and water extract with oil extractor, standby;

B, get effective ingredient Radix Salviae Miltiorrhizae 550 gram, Rhizoma Chuanxiong 300 grams, Flos Carthami 300 grams, add 5750 milliliter of 95% ethanol extraction secondary, each 1 hour, merge extractive liquid, filtered, and filtrate is 1.27-1.30 when being evaporated to relative density at 50 ℃ below 60 ℃;

C, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, about 288 grams of the medicinal residues of Flos Carthami and effective ingredient Radix Polygoni Multiflori 550 grams, Rhizoma Polygonati Odorati 550 grams, merging such as Poria 300 grams, add 8440 ml waters and decoct secondary, each 1 hour, collecting decoction, leave standstill, get supernatant, with Lignum Dalbergiae Odoriferae, Fructus Schisandrae Chinensis, the water extract of Herba Asari merges, and being evaporated to relative density is 1.06-1.09 in the time of 60 ℃, add 70%-95% ethanol, stir, standing over night is filtered, it is 1.28-1.32 in the time of 60 ℃ that filtrate decompression is concentrated into relative density, go to evaporation and concentration, to relative density be 1.38-1.40 60 ℃ the time, with Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, the alcohol extraction concentrated solution of Flos Carthami merges, add an amount of dextrin, mix thoroughly, drying under reduced pressure below 60 ℃ gets dry extract;

D, the dried cream of gained is mixed with artificial Moschus's 5 grams, Borneolum Syntheticum 5 grams, adds an amount of lactose pulverizing, mistake 80 mesh sieves add volatile oil such as above-mentioned Lignum Dalbergiae Odoriferae again, mixing, and dry method is made granule, and is promptly canned.Every bag of content 6 grams are equivalent to crude drug 19.47 grams.

Claims (2)

1, the anginal medicine of a kind of treatment, its effective ingredient is: Radix Salviae Miltiorrhizae 100-1000 gram, Rhizoma Chuanxiong 100-500 gram, Flos Carthami 100-500 gram, Radix Polygoni Multiflori 100-1000 gram, Rhizoma Polygonati Odorati 100-1000 gram, Poria 100-500 gram, Lignum Dalbergiae Odoriferae 100-500 gram, Fructus Schisandrae Chinensis 100-500 gram, Herba Asari 10-500 gram, artificial Moschus 0.001-10 gram, Borneolum Syntheticum 0.001-10 gram can make the 800-6000 gram.

2, a kind of preparation technology who treats anginal medicine is:

A, get effective ingredient Lignum Dalbergiae Odoriferae, Fructus Schisandrae Chinensis, Herba Asari, add 5 times of water gagings and soaked 12 hours, extracted volatile oil 8 hours, get volatile oil and water extract with oil extractor, standby;

B, get effective ingredient Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Flos Carthami, add 5 times of amount 95% ethanol extraction secondaries, each 1 hour, merge extractive liquid, filtered, and filtrate is 1.27-1.30 when being evaporated to relative density at 50 ℃ below 60 ℃;

C, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, the medicinal residues of Flos Carthami and effective ingredient Radix Polygoni Multiflori, Rhizoma Polygonati Odorati, merging such as Poria, add 5 times of water gagings and decoct secondary, each 1 hour, collecting decoction, leave standstill, get supernatant, with Lignum Dalbergiae Odoriferae, Fructus Schisandrae Chinensis, the water extract of Herba Asari merges, and being evaporated to relative density is 1.06-1.09 in the time of 60 ℃, add 70%-95% ethanol, stir, standing over night is filtered, it is 1.28-1.32 in the time of 60 ℃ that filtrate decompression is concentrated into relative density, go to evaporation and concentration, to relative density be 1.38-1.40 60 ℃ the time, with Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, the alcohol extraction concentrated solution of Flos Carthami merges, add an amount of dextrin, mix thoroughly, drying under reduced pressure below 60 ℃ gets dry extract;

D, dried cream and artificial Moschus, the Borneolum Syntheticum of gained mixed, add an amount of lactose and pulverize, cross 80 mesh sieves, add volatile oil such as above-mentioned Lignum Dalbergiae Odoriferae again, mixing, dry method is made granule, and is promptly canned.Every bag of content 6 grams are equivalent to crude drug 19.47 grams.