CN1602851A - Dripping pills of benactyzine hydrochloride and its preparation - Google Patents
Dripping pills of benactyzine hydrochloride and its preparation Download PDFInfo
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- CN1602851A CN1602851A CNA2004100553415A CN200410055341A CN1602851A CN 1602851 A CN1602851 A CN 1602851A CN A2004100553415 A CNA2004100553415 A CN A2004100553415A CN 200410055341 A CN200410055341 A CN 200410055341A CN 1602851 A CN1602851 A CN 1602851A
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- benactyzine
- benactyzine hydrochloride
- preparation
- coolant
- hydrochloride
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Abstract
The invention uses super micro shattering and benactyzine drop pills producing the technology to produce fenfluramine drop pills, reaching the purposes such as increasing speed, and dissolution of disintegration, increasing the medicine stability, reducing the dose of auxiliary materials and decreasing cost, with rapid effect and convenient use. It can be buccal as well as deglutition, has remarkable conformity, and is especially suitable for children, older man, sicker in bed or with difficulty of swallowing.
Description
Technical field
The present invention relates to a kind of pharmaceutical product and preparation method thereof, specifically benactyzine hydrochloride drop pill and preparation method thereof.
Background technology
Benactyzine hydrochloride has the visceral smooth muscle of alleviation spasm, reduces gastric acid secretion, the stable effect of maincenter.List marketing at present tablet, clinical gastric and duodenal ulcers, the cramps of gastrointestinal tract etc. of being used for are only arranged.
The benactyzine hydrochloride bitter in the mouth dissolves in water, but its disintegration of tablet time is longer, absorption difference, bioavailability is low, and the supplementary product consumption ratio is big, child, old people, bed patient and dysphagia patients are taken inconvenience, and compliance is poor, have influenced the performance of benactyzine hydrochloride therapeutical effect.
The present invention makes the benactyzine hydrochloride drop pill by using ultramicro communication technique and dropping pill formulation Technology exactly, thereby overcomes the above defective of benactyzine hydrochloride sheet, and the therapeutical effect of benactyzine hydrochloride is given full play to.
Summary of the invention
The benactyzine hydrochloride drop pill of making by using ultramicro communication technique and dropping pill formulation Technology not only have disintegrate molten loose fast, steady quality, the pill volume is little, and is easy to carry and use, and onset is rapid, compliance is good, be particularly suitable for the characteristics that child, old people, bed patient and dysphagia patients are taken, but also have working condition and production equipment is simple, production cost is low, compare the advantage that supplementary product consumption reduces with tablet, demonstrated fully the new drug research exploitation spirit that people-oriented.
For achieving the above object, the present invention by the following technical solutions: the benactyzine hydrochloride fine powder of 1 weight portion through micronizing is added in 5～30 weight portion molten matrix, fully mixing, dropping preparation method is condensed into ball in coolant, remove coolant, drying, promptly.
The chemical name of benactyzine hydrochloride is a 2-diethylamino ethyl diphenyl oxyacetate hydrochlorate among the present invention, and structural formula is
Molecular formula is C
20H
25NO
3Hcl, molecular weight are 363.9.
Substrate among the present invention includes but not limited to polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, cetomacrogol 1000, sodium stearate, glycerin gelatine, poloxamer, stearic acid, glycerol monostearate acid, insect wax etc.
Coolant among the present invention includes but not limited to dimethicone, liquid paraffin, vegetable oil, water, alcoholic solution etc.
Below through detecting to beneficial effect of the present invention as directed
One, detects index and method
Disintegrate (molten loosing) time limit: check according to inspection technique disintegration (two appendix XA of Chinese Pharmacopoeia version in 2000).
Two, commercially available benactyzine hydrochloride sheet disintegration time testing result: 32 minutes
Three, example 1 sample disintegrate (molten loosing) time detecting result: 2 minutes
Four, example 2 sample disintegrates (molten loosing) time detecting result: 2 minutes
Five, example 3 sample disintegrates (molten loosing) time detecting result: 3 minutes
Six, example 4 sample disintegrates (molten loosing) time detecting result: 3 minutes
Seven, example 5 sample disintegrates (molten loosing) time detecting result: 4 minutes
Eight, example 6 sample disintegrates (molten loosing) time detecting result: 5 minutes
The specific embodiment
One, example 1
Prescription:
Benactyzine hydrochloride 1g
Polyethylene glycol 6000 19g
Make 1000
Method for making: the benactyzine hydrochloride fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused polyethylene glycol 6000 substrate, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Two, example 2
Prescription:
Benactyzine hydrochloride 1g
Macrogol 4000 19g
Make 1000
Method for making: the benactyzine hydrochloride fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused Macrogol 4000 substrate, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Three, example 3
Prescription:
Benactyzine hydrochloride 1g
Polyethylene glycol 6000 12g
Macrogol 4000 7g
Make 1000
Method for making: the benactyzine hydrochloride fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in fused Macrogol 4000 and the polyethylene glycol 6000 mixed-matrix, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Four, example 4
Prescription:
Benactyzine hydrochloride 1g
Glyceryl monostearate 19g
Make 1000
Method for making: the benactyzine hydrochloride fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused glyceryl monostearate substrate, and mixing is a coolant with the frozen water, the dropping preparation method pill, and drying, promptly.
Five, example 5
Prescription:
Benactyzine hydrochloride 1g
Polyethylene glycol 6000 12g
Poloxamer 7g
Make 1000
Method for making: the benactyzine hydrochloride fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in fused polyethylene glycol 6000 and the poloxamer mixed-matrix, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Six, example 6
Prescription:
Benactyzine hydrochloride 1g
Glyceryl monostearate 17g
Poloxamer 2g
Make 1000
Method for making: get the mixing fine powders that benactyzine hydrochloride and poloxamer cross 200 mesh sieves through micronizing and be added in the fused glyceryl monostearate substrate, mixing is a coolant with the frozen water, the dropping preparation method pill, and drying, promptly.
Claims (4)
1. benactyzine hydrochloride drop pill and preparation method thereof is characterized in that: the benactyzine hydrochloride fine powder of 1 weight portion through micronizing is added in 5～30 weight portion molten matrix, fully mixing, dropping preparation method is condensed into ball in coolant, remove coolant, drying, promptly.
2. the chemical name of the described benactyzine hydrochloride of claim 1 is a 2-diethylamino ethyl diphenyl oxyacetate hydrochlorate, and structural formula is
, molecular formula is C
20H
25NO
3Hcl, molecular weight are 363.9.
3. the described substrate of claim 1 includes but not limited to polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, cetomacrogol 1000, sodium stearate, glycerin gelatine, poloxamer, stearic acid, glycerol monostearate acid, insect wax etc.
4. the described coolant of claim 1 includes but not limited to dimethicone, liquid paraffin, vegetable oil, water, alcoholic solution etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2004100553415A CN1602851A (en) | 2004-08-23 | 2004-08-23 | Dripping pills of benactyzine hydrochloride and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2004100553415A CN1602851A (en) | 2004-08-23 | 2004-08-23 | Dripping pills of benactyzine hydrochloride and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1602851A true CN1602851A (en) | 2005-04-06 |
Family
ID=34666173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2004100553415A Pending CN1602851A (en) | 2004-08-23 | 2004-08-23 | Dripping pills of benactyzine hydrochloride and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1602851A (en) |
-
2004
- 2004-08-23 CN CNA2004100553415A patent/CN1602851A/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |