CN1582913A - Drops of benzohydroxymethylamine and their preparation - Google Patents
Drops of benzohydroxymethylamine and their preparation Download PDFInfo
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- CN1582913A CN1582913A CN 200410044292 CN200410044292A CN1582913A CN 1582913 A CN1582913 A CN 1582913A CN 200410044292 CN200410044292 CN 200410044292 CN 200410044292 A CN200410044292 A CN 200410044292A CN 1582913 A CN1582913 A CN 1582913A
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- diphemin
- coolant
- preparation
- polyethylene glycol
- weight portion
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Abstract
A dripping pill of phenylhydroxyformamine hydrochloride is prepared by superfine pulverizing and conventional process for preparing dripping pills.
Description
Technical field
The present invention relates to a kind of pharmaceutical product and preparation method thereof, specifically Diphemin drop pill and preparation method thereof.
Background technology
Diphemin has the central analgesic activity and the atropinic spasmolysis of similar morphine, also has the smooth muscle relaxation effect of atropine-like secretoinhibitory and similar papaverine, in addition, effects such as antihistamine is arranged still.List marketing at present tablet, clinical various stomachaches, stomachache and the postoperative pain of being used for only arranged.
The Diphemin mildly bitter flavor dissolves in water, and its disintegration of tablet time is longer, absorption difference, bioavailability is low, and the supplementary product consumption ratio is big, child, old people, bed patient and dysphagia patients are taken inconvenience, and compliance is poor, have influenced the performance of Diphemin therapeutical effect.
The present invention makes the Diphemin drop pill by using ultramicro communication technique and dropping pill formulation Technology exactly, thereby overcomes the above defective of Diphemin sheet, and the therapeutical effect of Diphemin is given full play to.
Summary of the invention
The Diphemin drop pill of making by using ultramicro communication technique and dropping pill formulation Technology not only have disintegrate molten loose fast, steady quality, the pill volume is little, and is easy to carry and use, and onset is rapid, compliance is good, be particularly suitable for the characteristics that child, old people, bed patient and dysphagia patients are taken, but also have working condition and production equipment is simple, production cost is low, compare the advantage that supplementary product consumption reduces with tablet, demonstrated fully the new drug research exploitation spirit that people-oriented.
For achieving the above object, the present invention by the following technical solutions: the Diphemin fine powder of 1 weight portion through micronizing is added in 5～30 weight portion molten matrix, fully mixing, dropping preparation method is condensed into ball in coolant, remove coolant, drying, promptly.
The chemical name of Diphemin is the sweet ammonia ester hydrochloride of dimethyl chloro hydrobenzoin among the present invention, and structural formula is
Molecular formula is C
18H
21NO
3HCl, molecular weight are 335.84.
Substrate among the present invention includes but not limited to polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, cetomacrogol 1000, sodium stearate, glycerin gelatine, poloxamer, stearic acid, glycerol monostearate acid, insect wax etc.
Coolant among the present invention includes but not limited to dimethicone, liquid paraffin, vegetable oil, water, alcoholic solution etc.
Below through detecting to beneficial effect of the present invention as directed
One, detects index and method
Disintegrate (molten loosing) time limit: check according to inspection technique disintegration (two appendix XA of Chinese Pharmacopoeia version in 2000).
Two, commercially available Diphemin sheet disintegration time testing result: 49 minutes
Three, example 1 sample disintegrate (molten loosing) time detecting result: 3 minutes
Four, example 2 sample disintegrates (molten loosing) time detecting result: 2 minutes
Five, example 3 sample disintegrates (molten loosing) time detecting result: 3 minutes
Six, example 4 sample disintegrates (molten loosing) time detecting result: 4 minutes
Seven, example 5 sample disintegrates (molten loosing) time detecting result: 4 minutes
Eight, example 6 sample disintegrates (molten loosing) time detecting result: 6 minutes
The specific embodiment
One, example 1
Prescription:
Diphemin 1g
Polyethylene glycol 6000 20g
Make 1000
Method for making: the Diphemin fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused polyethylene glycol 6000 substrate, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Two, example 2
Prescription:
Diphemin 1g
Macrogol 4000 20g
Make 1000
Method for making: the Diphemin fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused Macrogol 4000 substrate, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Three, example 3
Prescription:
Diphemin 1g
Polyethylene glycol 6000 15g
Macrogol 4000 5g
Make 1000
Method for making: the Diphemin fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in fused Macrogol 4000 and the polyethylene glycol 6000 mixed-matrix, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Four, example 4
Prescription:
Diphemin 1g
Glyceryl monostearate 20g
Make 1000
Method for making: the Diphemin fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused glyceryl monostearate substrate, and mixing is a coolant with the frozen water, the dropping preparation method pill, and drying, promptly.
Five, example 5
Prescription:
Diphemin 1g
Polyethylene glycol 6000 15g
Poloxamer 5g
Make 1000
Method for making: the Diphemin fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in fused polyethylene glycol 6000 and the poloxamer mixed-matrix, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Six, example 6
Prescription:
Diphemin 1g
Glyceryl monostearate 18g
Poloxamer 2g
Make 1000
Method for making: get the mixing fine powders that Diphemin and poloxamer cross 200 mesh sieves through micronizing and be added in the fused glyceryl monostearate substrate, mixing is a coolant with the frozen water, the dropping preparation method pill, and drying, promptly.
Claims (4)
1. Diphemin drop pill and preparation method thereof is characterized in that: the Diphemin fine powder of 1 weight portion through micronizing is added in 5～30 weight portion molten matrix, fully mixing, dropping preparation method is condensed into ball in coolant, remove coolant, drying, promptly.
2. the chemical name of the described Diphemin of claim 1 is the sweet ammonia ester hydrochloride of dimethyl chloro hydrobenzoin, and structural formula is
Molecular formula is C
18H
21NO
3HCl, molecular weight are 335.84.
3. the described substrate of claim 1 includes but not limited to polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, cetomacrogol 1000, sodium stearate, glycerin gelatine, poloxamer, stearic acid, glycerol monostearate acid, insect wax etc.
4. the described coolant of claim 1 includes but not limited to dimethicone, liquid paraffin, vegetable oil, water, alcoholic solution etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410044292 CN1582913A (en) | 2004-05-21 | 2004-05-21 | Drops of benzohydroxymethylamine and their preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410044292 CN1582913A (en) | 2004-05-21 | 2004-05-21 | Drops of benzohydroxymethylamine and their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1582913A true CN1582913A (en) | 2005-02-23 |
Family
ID=34601732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410044292 Pending CN1582913A (en) | 2004-05-21 | 2004-05-21 | Drops of benzohydroxymethylamine and their preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1582913A (en) |
-
2004
- 2004-05-21 CN CN 200410044292 patent/CN1582913A/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |