CN1546035A - Lorazepam dripping pills and its preparation process - Google Patents
Lorazepam dripping pills and its preparation process Download PDFInfo
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- CN1546035A CN1546035A CNA2003101219249A CN200310121924A CN1546035A CN 1546035 A CN1546035 A CN 1546035A CN A2003101219249 A CNA2003101219249 A CN A2003101219249A CN 200310121924 A CN200310121924 A CN 200310121924A CN 1546035 A CN1546035 A CN 1546035A
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- China
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- lorazepam
- coolant
- polyethylene glycol
- preparation
- drop pill
- Prior art date
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Abstract
The invention relates to a Lorazepum drop pill prepared by utilizing ultramicro disintegration and drop pill manufacturing process, which has the advantages of improving collapse and dissolving speed, quick effect, increased medicament stability, reduced adjuvant consumption, lowered production costs, and easiness in carrying and use. It has good compliance, thus is especially suitable for children, the elderly, bedridden patients and dysphagia patients.
Description
Technical field
The present invention relates to a kind of pharmaceutical product and preparation method thereof, specifically lorazepam drop pill and preparation method thereof.
Background technology
Lorazepam (Lorazepam) is a benzodiazepine, and its effect is similar to diazepam, but angst resistance effect is strong than diazepam, and the sleep inducing effect is obvious.Oral absorption is good, rapid.Be about 85% with plasma protein binding rate.By hepatic metabolism, metabolite inanimate object activity.t
1/2Be about 10～18 hours.1～4 hour blood drug level peaking in oral back; Reach steady plasma-drug concentration after 2～3 days.Clinical anxiety neurosis, insomnia and the epilepsy of being used for.
Lorazepam sheet disintegration time is long, absorption difference, and bioavailability is low, and the supplementary product consumption ratio is big, and child, old people, bed patient and dysphagia patients are taken inconvenience, and compliance is poor, has influenced the performance of lorazepam therapeutical effect.
The present invention makes the lorazepam drop pill by using ultramicro communication technique and dropping pill formulation Technology exactly, thereby overcomes the above defective of lorazepam sheet, and the therapeutical effect of lorazepam is given full play to.
Summary of the invention
The lorazepam drop pill of making by using ultramicro communication technique and dropping pill formulation Technology not only have disintegrate molten loose fast, steady quality, the pill volume is little, both can swallow also can buccal, easy to carry and use, onset is rapid, compliance is good, be particularly suitable for the characteristics that child, old people, bed patient and dysphagia patients are taken, but also has working condition and production equipment is simple, production cost is low, compares the advantage that supplementary product consumption reduces with tablet, has demonstrated fully the new drug research exploitation spirit that people-oriented.
For achieving the above object, the present invention by the following technical solutions: the lorazepam fine powder of 1 weight portion through micronizing is added in 5～50 weight portion molten matrix, abundant mixing, dropping preparation method is condensed into ball in coolant, remove coolant, drying, promptly.
Substrate among the present invention includes but not limited to polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, cetomacrogol 1000, sodium stearate, glycerin gelatine, poloxamer, stearic acid, glycerol monostearate acid, insect wax etc.
Coolant among the present invention includes but not limited to dimethicone, liquid paraffin, vegetable oil, water, alcoholic solution etc.
Below through detecting to beneficial effect of the present invention as directed
One, detects index and method
Disintegrate (molten loosing) time limit: check according to inspection technique disintegration (two appendix XA of Chinese Pharmacopoeia version in 2000).
Two, commercially available lorazepam sheet disintegration time testing result: 56 minutes
Three, example 1 sample disintegrate (molten loosing) time detecting result: 3 minutes
Four, example 2 sample disintegrates (molten loosing) time detecting result: 2 minutes
Five, example 3 sample disintegrates (molten loosing) time detecting result: 4 minutes
Six, example 4 sample disintegrates (molten loosing) time detecting result: 7 minutes
Seven, example 5 sample disintegrates (molten loosing) time detecting result: 10 minutes
Eight, example 6 sample disintegrates (molten loosing) time detecting result: 12 minutes
The specific embodiment
One, example 1
Prescription:
Lorazepam 1g
Poly-ethanol 6000 19g
Make 1000
Method for making: the lorazepam fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused polyethylene glycol 6000 substrate, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Two, example 2
Prescription:
Lorazepam 1g
Macrogol 4000 19g
Make 1000
Method for making: the lorazepam fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused Macrogol 4000 substrate, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Three, example 3
Prescription:
Lorazepam 1g
Polyethylene glycol 6000 9g
Macrogol 4000 10g
Make 1000
Method for making: the lorazepam fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in fused Macrogol 4000 and the polyethylene glycol 6000 mixed-matrix, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Four, example 4
Prescription:
Lorazepam 1g
Glyceryl monostearate 19g
Make 1000
Method for making: the lorazepam fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused glyceryl monostearate substrate, and mixing is a coolant with the frozen water, the dropping preparation method pill, and drying, promptly.
Five, example 5
Prescription:
Lorazepam 1g
Polyethylene glycol 6000 15g
Poloxamer 4g
Make 1000
Method for making: the lorazepam fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in fused polyethylene glycol 6000 and the poloxamer mixed-matrix, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Six, example 6
Prescription:
Lorazepam 1g
Glyceryl monostearate 18g
Poloxamer 1g
Make 1000
Method for making: get the mixing fine powders that lorazepam and poloxamer cross 200 mesh sieves through micronizing and be added in the fused glyceryl monostearate substrate, mixing is a coolant with the frozen water, the dropping preparation method pill, and drying, promptly.
Claims (3)
1. lorazepam drop pill and preparation method thereof is characterized in that: the lorazepam fine powder of 1 weight portion through micronizing is added in 5～50 weight portion molten matrix, and abundant mixing, dropping preparation method is condensed into ball in coolant, remove coolant, drying, promptly.
2. the described substrate of claim 1 includes but not limited to polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, cetomacrogol 1000, sodium stearate, glycerin gelatine, poloxamer, stearic acid, glycerol monostearate acid, insect wax etc.
3. the described coolant of claim 1 includes but not limited to dimethicone, liquid paraffin, vegetable oil, water, alcoholic solution etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2003101219249A CN1546035A (en) | 2003-12-08 | 2003-12-08 | Lorazepam dripping pills and its preparation process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2003101219249A CN1546035A (en) | 2003-12-08 | 2003-12-08 | Lorazepam dripping pills and its preparation process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1546035A true CN1546035A (en) | 2004-11-17 |
Family
ID=34338575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2003101219249A Pending CN1546035A (en) | 2003-12-08 | 2003-12-08 | Lorazepam dripping pills and its preparation process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1546035A (en) |
-
2003
- 2003-12-08 CN CNA2003101219249A patent/CN1546035A/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |