CN1528304A - Anisodine hydrobromide drop pill and preparing method thereof - Google Patents
Anisodine hydrobromide drop pill and preparing method thereof Download PDFInfo
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- CN1528304A CN1528304A CNA2003101009202A CN200310100920A CN1528304A CN 1528304 A CN1528304 A CN 1528304A CN A2003101009202 A CNA2003101009202 A CN A2003101009202A CN 200310100920 A CN200310100920 A CN 200310100920A CN 1528304 A CN1528304 A CN 1528304A
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- anisodine hydrobromide
- hydrobromide
- anisodine
- coolant
- pill
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Abstract
The present invention utilizes ultramicropulverization and dripping pill preparation production process to make aniosidine hydrobromide dripping pills, and can attain the goal of raising disintegration and dissolution speed, quickly obtaining therapeutic effect, raising stability of medicine, reducing dose of auxiliary material, reducing production cost and convenient administration. Said pill not noly can be sucket, but also can be swallowed, and its compliance is good.
Description
Technical field
The present invention relates to a kind of pharmaceutical product and preparation method thereof, specifically Anisodine hydrobromide drop pill and preparation method thereof.
Background technology
Anisodine hydrobromide (Anisodine Hydromide) has tangible maincenter cholinolytic effect, it and acetylcholine are competed at M cholinoceptor position, stop acetylcholine to combine with the M cholinoceptor, thereby the block nerves impulsion is transmitted, and reaches the physiological function that interference is caused by the cholinergic nerve transmission.Can remove vasospasm, microcirculation improvement, have that antidetonation is quivered, spasmolytic, relieving asthma, suppress glandular secretion, pupil looses and the effect of antagonism organophosphorus compounds pesticide intoxication.Action intensity than atropine a little less than, and toxicity is little.List marketing at present tablet only arranged, the clinical caused acute paralysis of migraine, vascular headache, retinal angiospasm, ischemic optic neuropathy, nervous system inflammation and cerebrovascular, the Parkinsonism etc. of being used for the treatment of also can be used for the detoxifcation of organophosphorus compounds pesticide intoxication.
Anisodine hydrobromide sheet disintegration time is long, absorption difference, and bioavailability is low, and the supplementary product consumption ratio is big, and child, old people, bed patient and dysphagia patients are taken inconvenience, and compliance is poor, has influenced the performance of Anisodine hydrobromide therapeutical effect.
The present invention makes the Anisodine hydrobromide drop pill by using ultramicro communication technique and dropping pill formulation Technology exactly, thereby overcomes the above defective of Anisodine hydrobromide sheet, and the therapeutical effect of Anisodine hydrobromide is given full play to.
Summary of the invention
The Anisodine hydrobromide drop pill of making by using ultramicro communication technique and dropping pill formulation Technology not only have disintegrate molten loose fast, steady quality, the pill volume is little, both can swallow also can buccal, easy to carry and use, onset is rapid, compliance is good, be particularly suitable for the characteristics that child, old people, bed patient and dysphagia patients are taken, but also has working condition and production equipment is simple, production cost is low, compares the advantage that supplementary product consumption reduces with tablet, has demonstrated fully the new drug research exploitation spirit that people-oriented.
For achieving the above object, the present invention by the following technical solutions: the Anisodine hydrobromide fine powder of 1 weight portion through micronizing is added in 5～20 weight portion molten matrix, fully mixing, dropping preparation method is condensed into ball in coolant, remove coolant, drying, promptly.
The molecular formula of Anisodine hydrobromide is C among the present invention
17H
21NO
5HBr, molecular weight are 400.27.
Substrate among the present invention includes but not limited to polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, cetomacrogol 1000, sodium stearate, glycerin gelatine, poloxamer, stearic acid, glycerol monostearate acid, insect wax etc.
Coolant among the present invention includes but not limited to dimethicone, liquid paraffin, vegetable oil, water, alcoholic solution etc.
Below through detecting to beneficial effect of the present invention as directed
One, detects index and method
Disintegrate (molten loosing) time limit: check according to inspection technique disintegration (two appendix XA of Chinese Pharmacopoeia version in 2000).
Two, commercially available Anisodine hydrobromide sheet disintegration time testing result: 49 minutes
Three, example 1 sample disintegrate (molten loosing) time detecting result: 3 minutes
Four, example 2 sample disintegrates (molten loosing) time detecting result: 3 minutes
Five, example 3 sample disintegrates (molten loosing) time detecting result: 3 minutes
Six, example 4 sample disintegrates (molten loosing) time detecting result: 6 minutes
Seven, example 5 sample disintegrates (molten loosing) time detecting result: 10 minutes
Eight, example 6 sample disintegrates (molten loosing) time detecting result: 15 minutes
The specific embodiment
One, example 1
Prescription:
Anisodine hydrobromide 2g
Polyethylene glycol 6000 18g
Make 1000
Method for making: the Anisodine hydrobromide fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused polyethylene glycol 6000 substrate, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Two, example 2
Prescription:
Anisodine hydrobromide 2g
Macrogol 4000 18g
Make 1000
Method for making: the Anisodine hydrobromide fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused Macrogol 4000 substrate, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Three, example 3
Prescription:
Anisodine hydrobromide 2g
Polyethylene glycol 6000 8g
Macrogol 4000 10g
Make 1000
Method for making: the Anisodine hydrobromide fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in fused Macrogol 4000 and the polyethylene glycol 6000 mixed-matrix, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Four, example 4
Prescription:
Anisodine hydrobromide 2g
Glyceryl monostearate 18g
Make 1000
Method for making: the Anisodine hydrobromide fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused glyceryl monostearate substrate, and mixing is a coolant with the frozen water, the dropping preparation method pill, and drying, promptly.
Five, example 5
Prescription:
Anisodine hydrobromide 2g
Polyethylene glycol 6000 13g
Poloxamer 5g
Make 1000
Method for making: the Anisodine hydrobromide fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in fused polyethylene glycol 6000 and the poloxamer mixed-matrix, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Six, example 6
Prescription:
Anisodine hydrobromide 2g
Glyceryl monostearate 16g
Poloxamer 2g
Make 1000
Method for making: get the mixing fine powders that Anisodine hydrobromide and poloxamer cross 200 mesh sieves through micronizing and be added in the fused glyceryl monostearate substrate, mixing is a coolant with the frozen water, the dropping preparation method pill, and drying, promptly.
Claims (4)
1. Anisodine hydrobromide drop pill and preparation method thereof is characterized in that: the Anisodine hydrobromide fine powder of 1 weight portion through micronizing is added in 5～20 weight portion molten matrix, fully mixing, dropping preparation method is condensed into ball in coolant, remove coolant, drying, promptly.
2. the molecular formula of the described Anisodine hydrobromide of claim 1 is C
17H
21NO
5HBr, molecular weight are 400.27.
3. the described substrate of claim 1 includes but not limited to polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, cetomacrogol 1000, sodium stearate, glycerin gelatine, poloxamer, stearic acid, glycerol monostearate acid, insect wax etc.
4. the described coolant of claim 1 includes but not limited to dimethicone, liquid paraffin, vegetable oil, water, alcoholic solution etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2003101009202A CN1528304A (en) | 2003-10-08 | 2003-10-08 | Anisodine hydrobromide drop pill and preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2003101009202A CN1528304A (en) | 2003-10-08 | 2003-10-08 | Anisodine hydrobromide drop pill and preparing method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1528304A true CN1528304A (en) | 2004-09-15 |
Family
ID=34304113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2003101009202A Pending CN1528304A (en) | 2003-10-08 | 2003-10-08 | Anisodine hydrobromide drop pill and preparing method thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN1528304A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105820164A (en) * | 2016-05-01 | 2016-08-03 | 成都第制药原料药有限公司 | Crystal form D of anisodine hydrobromide as well as preparation method and use of crystal form D |
| CN105859711A (en) * | 2016-05-01 | 2016-08-17 | 成都第制药原料药有限公司 | Crystal form B of anisodine hydromide and preparation method and application of crystal form B |
| CN105906620A (en) * | 2016-05-01 | 2016-08-31 | 成都第制药原料药有限公司 | Anisodine hydromide crystal form C, and preparation method and application thereof |
-
2003
- 2003-10-08 CN CNA2003101009202A patent/CN1528304A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105820164A (en) * | 2016-05-01 | 2016-08-03 | 成都第制药原料药有限公司 | Crystal form D of anisodine hydrobromide as well as preparation method and use of crystal form D |
| CN105859711A (en) * | 2016-05-01 | 2016-08-17 | 成都第制药原料药有限公司 | Crystal form B of anisodine hydromide and preparation method and application of crystal form B |
| CN105906620A (en) * | 2016-05-01 | 2016-08-31 | 成都第制药原料药有限公司 | Anisodine hydromide crystal form C, and preparation method and application thereof |
| CN105906620B (en) * | 2016-05-01 | 2020-08-11 | 成都第一制药有限公司 | Crystal form C of anisodine hydrobromide, preparation method and application thereof |
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| WD01 | Invention patent application deemed withdrawn after publication |