CN1528335A - Shii-take fungus polysaccharide drop pill and preparing method thereof - Google Patents
Shii-take fungus polysaccharide drop pill and preparing method thereof Download PDFInfo
- Publication number
- CN1528335A CN1528335A CNA031433359A CN03143335A CN1528335A CN 1528335 A CN1528335 A CN 1528335A CN A031433359 A CNA031433359 A CN A031433359A CN 03143335 A CN03143335 A CN 03143335A CN 1528335 A CN1528335 A CN 1528335A
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- CN
- China
- Prior art keywords
- lentinula edodes
- mycelium polysaccharide
- edodes mycelium
- coolant
- drop pill
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abstract
The present invention utilizes ultramicropulverization and dripping pill preparation production process to produce lentinan dripping pills, and can attain the goal of raising disintegration dissolution speed, quickly obtaining therapeutic effect, raising stability, reducing dose of auxiliary material, reducing production cost and convenient administration, it not only can be sucked, but also can be swallowed, and its compliance is good.
Description
Technical field
The present invention relates to a kind of pharmaceutical product and preparation method thereof, specifically Lentinula edodes mycelium polysaccharide drop pill and preparation method thereof.
Background technology
Lentinula edodes mycelium polysaccharide is an immunostimulant.Strengthen the ability of host anti-virus, antitumor and bacterial infection, the toxicity of ameliorate tumor chemotherapy medicine by the immune system that activates body.List marketing at present tablet only arranged, the clinical various diseases that lowly causes because of autoimmune function of being used for, and be used for chronic viral hepatitis, liver protecting therapy; Also can be used as the chemotherapy of tumors ancillary drug.
The Lentinula edodes mycelium polysaccharide odorless has and draws moistly, and its disintegration of tablet time is long, absorption difference, bioavailability is low, and the supplementary product consumption ratio is big, child, old people, bed patient and dysphagia patients are taken inconvenience, and compliance is poor, have influenced the performance of Lentinula edodes mycelium polysaccharide therapeutical effect.
The present invention makes the Lentinula edodes mycelium polysaccharide drop pill by using ultramicro communication technique and dropping pill formulation Technology exactly, thereby overcomes the above defective of Lentinula edodes mycelium polysaccharide sheet, and the therapeutical effect of Lentinula edodes mycelium polysaccharide is given full play to.
Summary of the invention
The Lentinula edodes mycelium polysaccharide drop pill of making by using ultramicro communication technique and dropping pill formulation Technology not only have disintegrate molten loose fast, steady quality, the pill volume is little, both can swallow also can buccal, easy to carry and use, onset is rapid, compliance is good, be particularly suitable for the characteristics that child, old people, bed patient and dysphagia patients are taken, but also has working condition and production equipment is simple, production cost is low, compares the advantage that supplementary product consumption reduces with tablet, has demonstrated fully the new drug research exploitation spirit that people-oriented.
For achieving the above object, the present invention by the following technical solutions: the Lentinula edodes mycelium polysaccharide fine powder of 1 weight portion through micronizing is added in 1～10 weight portion molten matrix, abundant mixing, dropping preparation method is condensed into ball in coolant, remove coolant, drying, promptly.
Substrate among the present invention includes but not limited to polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, cetomacrogol 1000, sodium stearate, glycerin gelatine, poloxamer, stearic acid, glycerol monostearate acid, insect wax etc.
Coolant among the present invention includes but not limited to dimethicone, liquid paraffin, vegetable oil, water, alcoholic solution etc.
Below through detecting to beneficial effect of the present invention as directed
One, detects index and method
Disintegrate (molten loosing) time limit: check according to inspection technique disintegration (two appendix XA of Chinese Pharmacopoeia version in 2000).
Two, commercially available Lentinula edodes mycelium polysaccharide sheet disintegration time testing result: 49 minutes
Three, example 1 sample disintegrate (molten loosing) time detecting result: 2 minutes
Four, example 2 sample disintegrates (molten loosing) time detecting result: 2 minutes
Five, example 3 sample disintegrates (molten loosing) time detecting result: 3 minutes
Six, example 4 sample disintegrates (molten loosing) time detecting result: 6 minutes
Seven, example 5 sample disintegrates (molten loosing) time detecting result: 8 minutes
Eight, example 6 sample disintegrates (molten loosing) time detecting result: 7 minutes
The specific embodiment
One, example 1
Prescription:
Lentinula edodes mycelium polysaccharide 5g
Polyethylene glycol 6000 15g
Make 1000
Method for making: the Lentinula edodes mycelium polysaccharide fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused polyethylene glycol 6000 substrate, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Two, example 2
Prescription:
Lentinula edodes mycelium polysaccharide 5g
Macrogol 4000 15g
Make 1000
Method for making: the Lentinula edodes mycelium polysaccharide fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused Macrogol 4000 substrate, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Three, example 3
Prescription:
Lentinula edodes mycelium polysaccharide 5g
Polyethylene glycol 6000 5g
Macrogol 4000 10g
Make 1000
Method for making: the Lentinula edodes mycelium polysaccharide fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in fused Macrogol 4000 and the polyethylene glycol 6000 mixed-matrix, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Four, example 4
Prescription:
Lentinula edodes mycelium polysaccharide 5g
Glyceryl monostearate 15g
Make 1000
Method for making: the Lentinula edodes mycelium polysaccharide fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused glyceryl monostearate substrate, and mixing is a coolant with the frozen water, the dropping preparation method pill, and drying, promptly.
Five, example 5
Prescription:
Lentinula edodes mycelium polysaccharide 5g
Polyethylene glycol 6000 10g
Poloxamer 5g
Make 1000
Method for making: the Lentinula edodes mycelium polysaccharide fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in fused polyethylene glycol 6000 and the poloxamer mixed-matrix, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Six, example 6
Prescription:
Lentinula edodes mycelium polysaccharide 5g
Glyceryl monostearate 15g
Poloxamer 1g
Make 1000
Method for making: get the mixing fine powders that Lentinula edodes mycelium polysaccharide and poloxamer cross 200 mesh sieves through micronizing and be added in the fused glyceryl monostearate substrate, mixing is a coolant with the frozen water, the dropping preparation method pill, and drying, promptly.
Claims (3)
1. Lentinula edodes mycelium polysaccharide drop pill and preparation method thereof is characterized in that: the Lentinula edodes mycelium polysaccharide fine powder of 1 weight portion through micronizing is added in 1～10 weight portion molten matrix, fully mixing, dropping preparation method is condensed into ball in coolant, remove coolant, drying, promptly.
2. the described substrate of claim 1 includes but not limited to polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, cetomacrogol 1000, sodium stearate, glycerin gelatine, poloxamer, stearic acid, glycerol monostearate acid, insect wax etc.
3. the described coolant of claim 1 includes but not limited to dimethicone, liquid paraffin, vegetable oil, water, alcoholic solution etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031433359A CN1528335A (en) | 2003-09-27 | 2003-09-27 | Shii-take fungus polysaccharide drop pill and preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031433359A CN1528335A (en) | 2003-09-27 | 2003-09-27 | Shii-take fungus polysaccharide drop pill and preparing method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1528335A true CN1528335A (en) | 2004-09-15 |
Family
ID=34286559
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA031433359A Pending CN1528335A (en) | 2003-09-27 | 2003-09-27 | Shii-take fungus polysaccharide drop pill and preparing method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1528335A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7514085B2 (en) | 2004-07-16 | 2009-04-07 | Medimush A/S | Immune modulating compounds from fungi |
| US8758768B2 (en) | 2001-09-03 | 2014-06-24 | Glycanova As | Process for production of fungal extracellular immune stimulating compounds |
| US9072776B2 (en) | 2005-06-15 | 2015-07-07 | Glycanova As | Anti-cancer combination treatment and kit-of-parts |
-
2003
- 2003-09-27 CN CNA031433359A patent/CN1528335A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8758768B2 (en) | 2001-09-03 | 2014-06-24 | Glycanova As | Process for production of fungal extracellular immune stimulating compounds |
| US9249438B2 (en) | 2001-09-03 | 2016-02-02 | Glycanova As | Production of fungal extracellular immune stimulating compounds |
| US10471135B2 (en) | 2001-09-03 | 2019-11-12 | Glycanova As | Production of fungal extracellular immune stimulating compounds |
| US7514085B2 (en) | 2004-07-16 | 2009-04-07 | Medimush A/S | Immune modulating compounds from fungi |
| US7682615B2 (en) | 2004-07-16 | 2010-03-23 | Beka Holding As | Immune modulating compounds from fungi |
| US9072776B2 (en) | 2005-06-15 | 2015-07-07 | Glycanova As | Anti-cancer combination treatment and kit-of-parts |
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|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |