CN1528337A - Lentinan drop pill and preparing method thereof - Google Patents
Lentinan drop pill and preparing method thereof Download PDFInfo
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- CN1528337A CN1528337A CNA2003101009217A CN200310100921A CN1528337A CN 1528337 A CN1528337 A CN 1528337A CN A2003101009217 A CNA2003101009217 A CN A2003101009217A CN 200310100921 A CN200310100921 A CN 200310100921A CN 1528337 A CN1528337 A CN 1528337A
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- lentinan
- coolant
- polyethylene glycol
- preparation
- lentinus
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Abstract
The present invention utilizes ultramicropulverization and dripping pill preparation production process to produce lentinan dripping pills and can attain the goal of raising disintegration dissolution speed, quickl-obtaining effect, raising stability of medicine, reducing dose of auxiliary material, reducing production cost and convenient administration, it not only can be sucked, but also can be swallowed, and its compliance is good.
Description
Technical field
The present invention relates to a kind of pharmaceutical product and preparation method thereof, specifically drop pills of lentinan and preparation method thereof.
Background technology
Lentinan is the Agaricaceae fungus Lentinus Edodes fungus of artificial separation and Culture, the polysaccharide that extracts through Lentinus Edodes [Lentinus edodes (Berk) Sing] sporophore of inoculated and cultured, has replenishing QI to invigorate the spleen, the effect that tonify deficiency is set upright is used for the putting of chronic type b chronic persistent hepatitis and digestive tract tumor, chemotherapy adjuvant.
The lentinan odorless dissolves in water, but its disintegration of tablet time is long, absorption difference, bioavailability is low, and the supplementary product consumption ratio is big, child, old people, bed patient and dysphagia patients are taken inconvenience, and compliance is poor, have influenced the performance of lentinan therapeutical effect.
The present invention makes the drop pills of lentinan agent by using ultramicro communication technique and dropping pill formulation Technology exactly, thereby overcomes the above defective of lentinan film, and the therapeutical effect of lentinan is given full play to.
Summary of the invention
The drop pills of lentinan of making by using ultramicro communication technique and dropping pill formulation Technology not only have disintegrate molten loose fast, steady quality, the pill volume is little, both can swallow also can buccal, easy to carry and use, onset is rapid, compliance is good, be particularly suitable for the characteristics that child, old people, bed patient and dysphagia patients are taken, but also has working condition and production equipment is simple, production cost is low, compares the advantage that supplementary product consumption reduces with tablet, has demonstrated fully the new drug research exploitation spirit that people-oriented.
For achieving the above object, the present invention by the following technical solutions: the lentinan fine powder of 1 weight portion through micronizing is added in 1～10 weight portion molten matrix, abundant mixing, dropping preparation method is condensed into ball in coolant, remove coolant, drying, promptly.
Substrate among the present invention includes but not limited to polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, cetomacrogol 1000, sodium stearate, glycerin gelatine, poloxamer, stearic acid, glycerol monostearate acid, insect wax etc.
Coolant among the present invention includes but not limited to dimethicone, liquid paraffin, vegetable oil, water, alcoholic solution etc.
Below through detecting to beneficial effect of the present invention as directed
One, detects index and method
Disintegrate (molten loosing) time limit: check according to inspection technique disintegration (two appendix XA of Chinese Pharmacopoeia version in 2000).
Two, commercially available lentinan film disintegration time testing result: 46 minutes
Three, example 1 sample disintegrate (molten loosing) time detecting result: 2 minutes
Four, example 2 sample disintegrates (molten loosing) time detecting result: 3 minutes
Five, example 3 sample disintegrates (molten loosing) time detecting result: 2 minutes
Six, example 4 sample disintegrates (molten loosing) time detecting result: 5 minutes
Seven, example 5 sample disintegrates (molten loosing) time detecting result: 8 minutes
Eight, example 6 sample disintegrates (molten loosing) time detecting result: 10 minutes
The specific embodiment
One, example 1
Prescription:
Lentinan 5g
Polyethylene glycol 6000 15g
Make 1000
Method for making: the lentinan fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused polyethylene glycol 6000 substrate, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Two, example 2
Prescription:
Lentinan 5g
Macrogol 4000 15g
Make 1000
Method for making: the lentinan fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused Macrogol 4000 substrate, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Three, example 3
Prescription:
Lentinan 5g
Polyethylene glycol 6000 5g
Macrogol 4000 10g
Make 1000
Method for making: the lentinan fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in fused Macrogol 4000 and the polyethylene glycol 6000 mixed-matrix, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Four, example 4
Prescription:
Lentinan 5g
Glyceryl monostearate 15g
Make 1000
Method for making: the lentinan fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused glyceryl monostearate substrate, and mixing is a coolant with the frozen water, the dropping preparation method pill, and drying, promptly.
Five, example 5
Prescription:
Lentinan 5g
Polyethylene glycol 6000 10g
Poloxamer 5g
Make 1000
Method for making: the lentinan fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in fused polyethylene glycol 6000 and the poloxamer mixed-matrix, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Six, example 6
Prescription:
Lentinan 5g
Glyceryl monostearate 15g
Poloxamer 1g
Make 1000
Method for making: get the mixing fine powders that lentinan and poloxamer cross 200 mesh sieves through micronizing and be added in the fused glyceryl monostearate substrate, mixing is a coolant with the frozen water, the dropping preparation method pill, and drying, promptly.
Claims (4)
1. drop pills of lentinan and preparation method thereof is characterized in that: the lentinan fine powder of 1 weight portion through micronizing is added in 1～10 weight portion molten matrix, and abundant mixing, dropping preparation method is condensed into ball in coolant, remove coolant, drying, promptly.
2. the described lentinan of claim 1 is the Agaricaceae fungus Lentinus Edodes fungus of artificial separation and Culture, through the polysaccharide of the Lentinus Edodes Lentinus of inoculated and cultured edodes Berk Sing sporophore extraction.
3. the described substrate of claim 1 includes but not limited to polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, cetomacrogol 1000, sodium stearate, glycerin gelatine, poloxamer, stearic acid, glycerol monostearate acid, insect wax etc.
4. the described coolant of claim 1 includes but not limited to dimethicone, liquid paraffin, vegetable oil, water, alcoholic solution etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2003101009217A CN1528337A (en) | 2003-10-08 | 2003-10-08 | Lentinan drop pill and preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2003101009217A CN1528337A (en) | 2003-10-08 | 2003-10-08 | Lentinan drop pill and preparing method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1528337A true CN1528337A (en) | 2004-09-15 |
Family
ID=34304114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2003101009217A Pending CN1528337A (en) | 2003-10-08 | 2003-10-08 | Lentinan drop pill and preparing method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1528337A (en) |
-
2003
- 2003-10-08 CN CNA2003101009217A patent/CN1528337A/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |