CN1568990A - Dripping pills of cyproheptadine hydrochloride and its preparation method - Google Patents
Dripping pills of cyproheptadine hydrochloride and its preparation method Download PDFInfo
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- CN1568990A CN1568990A CNA2004100444460A CN200410044446A CN1568990A CN 1568990 A CN1568990 A CN 1568990A CN A2004100444460 A CNA2004100444460 A CN A2004100444460A CN 200410044446 A CN200410044446 A CN 200410044446A CN 1568990 A CN1568990 A CN 1568990A
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- CN
- China
- Prior art keywords
- cyproheptadine hydrochloride
- coolant
- preparation
- polyethylene glycol
- cyproheptadine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abstract
The invention discloses a cyproheptadine hydrochloride drop pill prepared through ultramicro disintegration and drop pills manufacturing technique, which has the advantages of improving collapse and dissolving speed, quick effect, increased medicament stability, reduced adjuvant consumption, lowered production costs, and easiness in carrying and use. It has good compliance, thus is especially suitable for children, the elderly, bedridden patients and dysphagia patients.
Description
Technical field
The present invention relates to a kind of pharmaceutical product and preparation method thereof, specifically cyproheptadine hydrochloride drop pill and preparation method thereof.
Background technology
Cyproheptadine hydrochloride is H
1Receptor antagonist, effect is strong than chlorphenamine, promethazine, and antiserotonergic effect and cholinolytic effect light, moderate are arranged, so its energy blocking 5-hydroxytryptamine to the effect of blood vessel, intestinal and other smooth muscle, can be used as the depressant of vascular headache.
The cyproheptadine hydrochloride oral absorption is better, about 8 hours of acting duration.Product in the body after most of drug metabolism combines with glucuronic acid, mainly by urine excretion, still has a small amount of original shape medicine and metabolite to be discharged by feces.The elimination speed of renal dysfunction person medicine slows down.List marketing at present tablet only arranged, clinically be used for urticaria, eczema, allergic dermatitis and contact dermatitis, skin pruritus, rhinitis, migraine, asthma etc. as antihistaminic.
The cyproheptadine hydrochloride mildly bitter flavor, slightly soluble in water, its disintegration of tablet time is longer, absorption difference, bioavailability is low, and the supplementary product consumption ratio is big, child, old people, bed patient and dysphagia patients are taken inconvenience, and compliance is poor, have influenced the performance of cyproheptadine hydrochloride therapeutical effect.
The present invention makes the cyproheptadine hydrochloride drop pill by using ultramicro communication technique and dropping pill formulation Technology exactly, thereby overcomes the above defective of cyproheptadin hydrochloride tablet, and the therapeutical effect of cyproheptadine hydrochloride is given full play to.
Summary of the invention
The cyproheptadine hydrochloride drop pill of making by using ultramicro communication technique and dropping pill formulation Technology not only have disintegrate molten loose fast, steady quality, the pill volume is little, and is easy to carry and use, and onset is rapid, compliance is good, be particularly suitable for the characteristics that child, old people, bed patient and dysphagia patients are taken, but also have working condition and production equipment is simple, production cost is low, compare the advantage that supplementary product consumption reduces with tablet, demonstrated fully the new drug research exploitation spirit that people-oriented.
For achieving the above object, the present invention by the following technical solutions: the cyproheptadine hydrochloride fine powder of 1 weight portion through micronizing is added in 1～10 weight portion molten matrix, abundant mixing, dropping preparation method is condensed into ball in coolant, remove coolant, drying, promptly.
The chemical name of cyproheptadine hydrochloride is 1-methyl-4-(5H-dibenzo [a, d] cycloheptatriene-5-subunit) piperidine hydrochlorate sesquialter hydrate among the present invention, and molecular formula is C
21H
21NHcl1 H
2O, molecular weight are 350.89, and structural formula is
Hcl, 1 H
2O.
Substrate among the present invention includes but not limited to polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, cetomacrogol 1000, sodium stearate, glycerin gelatine, poloxamer, stearic acid, glycerol monostearate acid, insect wax etc.
Coolant among the present invention includes but not limited to dimethicone, liquid paraffin, vegetable oil, water, alcoholic solution etc.
Below through detecting to beneficial effect of the present invention as directed
One, detects index and method
Disintegrate (molten loosing) time limit: check according to inspection technique disintegration (two appendix XA of Chinese Pharmacopoeia version in 2000).
Two, commercially available cyproheptadin hydrochloride tablet disintegration time testing result: 56 minutes
Three, example 1 sample disintegrate (molten loosing) time detecting result: 2 minutes
Four, example 2 sample disintegrates (molten loosing) time detecting result: 3 minutes
Five, example 3 sample disintegrates (molten loosing) time detecting result: 2 minutes
Six, example 4 sample disintegrates (molten loosing) time detecting result: 5 minutes
Seven, example 5 sample disintegrates (molten loosing) time detecting result: 8 minutes
Eight, example 6 sample disintegrates (molten loosing) time detecting result: 8 minutes
The specific embodiment
One, example 1
Prescription:
Cyproheptadine hydrochloride 2g
Polyethylene glycol 6000 18g
Make 1000
Method for making: the cyproheptadine hydrochloride fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused polyethylene glycol 6000 substrate, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Two, example 2
Prescription:
Cyproheptadine hydrochloride 2g
Macrogol 4000 18g
Make 1000
Method for making: the cyproheptadine hydrochloride fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused Macrogol 4000 substrate, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Three, example 3
Prescription:
Cyproheptadine hydrochloride 2g
Polyethylene glycol 6000 12g
Macrogol 4000 6g
Make 1000
Method for making: the cyproheptadine hydrochloride fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in fused Macrogol 4000 and the polyethylene glycol 6000 mixed-matrix, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Four, example 4
Prescription:
Cyproheptadine hydrochloride 2g
Glyceryl monostearate 18g
Make 1000
Method for making: the cyproheptadine hydrochloride fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused glyceryl monostearate substrate, and mixing is a coolant with the frozen water, the dropping preparation method pill, and drying, promptly.
Five, example 5
Prescription:
Cyproheptadine hydrochloride 2g
Polyethylene glycol 6000 12g
Poloxamer 6g
Make 1000
Method for making: the cyproheptadine hydrochloride fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in fused polyethylene glycol 6000 and the poloxamer mixed-matrix, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Six, example 6
Prescription:
Cyproheptadine hydrochloride 2g
Glyceryl monostearate 16g
Poloxamer 2g
Make 1000
Method for making: get the mixing fine powders that cyproheptadine hydrochloride and poloxamer cross 200 mesh sieves through micronizing and be added in the fused glyceryl monostearate substrate, mixing is a coolant with the frozen water, the dropping preparation method pill, and drying, promptly.
Claims (4)
1. cyproheptadine hydrochloride drop pill and preparation method thereof is characterized in that: the cyproheptadine hydrochloride fine powder of 1 weight portion through micronizing is added in 1～10 weight portion molten matrix, fully mixing, dropping preparation method is condensed into ball in coolant, remove coolant, drying, promptly.
2. the chemical name of the described cyproheptadine hydrochloride of claim 1 is 1-methyl-4-(5H-dibenzo [a, d] cycloheptatriene-5-subunit) piperidine hydrochlorate sesquialter hydrate, and molecular formula is C
21H
21NHcl1 H
2O, molecular weight are 350.89, and structural formula is
Hcl, 1 H
2O.
3. the described substrate of claim 1 includes but not limited to polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, cetomacrogol 1000, sodium stearate, glycerin gelatine, poloxamer, stearic acid, glycerol monostearate acid, insect wax etc.
4. the described coolant of claim 1 includes but not limited to dimethicone, liquid paraffin, vegetable oil, water, alcoholic solution etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2004100444460A CN1568990A (en) | 2004-05-13 | 2004-05-13 | Dripping pills of cyproheptadine hydrochloride and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2004100444460A CN1568990A (en) | 2004-05-13 | 2004-05-13 | Dripping pills of cyproheptadine hydrochloride and its preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1568990A true CN1568990A (en) | 2005-01-26 |
Family
ID=34481896
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2004100444460A Pending CN1568990A (en) | 2004-05-13 | 2004-05-13 | Dripping pills of cyproheptadine hydrochloride and its preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1568990A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111643462A (en) * | 2020-06-24 | 2020-09-11 | 上海复旦复华药业有限公司 | Formula and process for producing cyproheptadine hydrochloride tablets with high curative effect |
| WO2022188898A3 (en) * | 2021-12-04 | 2022-11-03 | 中国农业科学院兰州兽医研究所 | Use of cyproheptadine hydrochloride compound in preparation of drug for preventing or treating african swine fever |
-
2004
- 2004-05-13 CN CNA2004100444460A patent/CN1568990A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111643462A (en) * | 2020-06-24 | 2020-09-11 | 上海复旦复华药业有限公司 | Formula and process for producing cyproheptadine hydrochloride tablets with high curative effect |
| WO2022188898A3 (en) * | 2021-12-04 | 2022-11-03 | 中国农业科学院兰州兽医研究所 | Use of cyproheptadine hydrochloride compound in preparation of drug for preventing or treating african swine fever |
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|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |