CN1546034A - Dripping pills of meloxicam and its preparation - Google Patents
Dripping pills of meloxicam and its preparation Download PDFInfo
- Publication number
- CN1546034A CN1546034A CNA200310121922XA CN200310121922A CN1546034A CN 1546034 A CN1546034 A CN 1546034A CN A200310121922X A CNA200310121922X A CN A200310121922XA CN 200310121922 A CN200310121922 A CN 200310121922A CN 1546034 A CN1546034 A CN 1546034A
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- meloxicam
- preparation
- coolant
- polyethylene glycol
- drop pill
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Abstract
The invention relates to a meloxicam drop pill prepared by utilizing ultramicro disintegration and drop pill manufacturing process, which has the advantages of improving collapse and dissolving speed, quick effect, increased medicament stability, reduced adjuvant consumption, lowered production costs, and easiness in carrying and use. It has good compliance, thus is especially suitable for children, the elderly, bedridden patients and dysphagia patients.
Description
Technical field
The present invention relates to a kind of pharmaceutical product and preparation method thereof, specifically meloxicam drop pill and preparation method thereof.
Background technology
Meloxicam is the enol acid NSAID (non-steroidal anti-inflammatory drug), has antiinflammatory, analgesia and refrigeration function.Optionally suppress Cycloxygenase-2 (Cox-2), a little less than the inhibitory action to Cycloxygenase-1, so untoward reaction such as digestive system is few.
Meloxicam is oral, rectally is drawn and received well, and after the oral absorption, the medicine in the blood plasma more than 99% combines with plasma protein, and the half-life is about 20 hours.Metabolite about 50% is discharged from urine, and all the other are discharged from feces.When hepatic insufficiency or light, moderate renal insufficiency, pharmacokinetic parameter does not have significant change.Be applicable to the arthritic symptomatic treatment of rheumatoid arthritis and painful.
The meloxicam tablet disintegration time is long, absorption difference, and bioavailability is low, and the supplementary product consumption ratio is big, and child, old people, bed patient and dysphagia patients are taken inconvenience, and compliance is poor, has influenced the performance of meloxicam therapeutical effect.
The present invention makes the meloxicam drop pill by using ultramicro communication technique and dropping pill formulation Technology exactly, thereby overcomes the above defective of meloxicam tablet, and the therapeutical effect of meloxicam is given full play to.
Summary of the invention
The meloxicam drop pill of making by using ultramicro communication technique and dropping pill formulation Technology not only have disintegrate molten loose fast, steady quality, the pill volume is little, both can swallow also can buccal, easy to carry and use, onset is rapid, compliance is good, be particularly suitable for the characteristics that child, old people, bed patient and dysphagia patients are taken, but also has working condition and production equipment is simple, production cost is low, compares the advantage that supplementary product consumption reduces with tablet, has demonstrated fully the new drug research exploitation spirit that people-oriented.
For achieving the above object, the present invention by the following technical solutions: the meloxicam fine powder of 1 weight portion through micronizing is added in 1～10 weight portion molten matrix, abundant mixing, dropping preparation method is condensed into ball in coolant, remove coolant, drying, promptly.
The structural formula of meloxicam among the present invention (Meloxicam) is
Substrate among the present invention includes but not limited to polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, cetomacrogol 1000, sodium stearate, glycerin gelatine, poloxamer, stearic acid, glycerol monostearate acid, insect wax etc.
Coolant among the present invention includes but not limited to dimethicone, liquid paraffin, vegetable oil, water, alcoholic solution etc.
Below through detecting to beneficial effect of the present invention as directed
One, detects index and method
Disintegrate (molten loosing) time limit: check according to inspection technique disintegration (two appendix XA of Chinese Pharmacopoeia version in 2000).
Two, commercially available meloxicam tablet disintegration time testing result: 59 minutes
Three, example 1 sample disintegrate (molten loosing) time detecting result: 2 minutes
Four, example 2 sample disintegrates (molten loosing) time detecting result: 3 minutes
Five, example 3 sample disintegrates (molten loosing) time detecting result: 2 minutes
Six, example 4 sample disintegrates (molten loosing) time detecting result: 6 minutes
Seven, example 5 sample disintegrates (molten loosing) time detecting result: 9 minutes
Eight, example 6 sample disintegrates (molten loosing) time detecting result: 8 minutes
The specific embodiment
One, example 1
Prescription:
Meloxicam 7.5g
Polyethylene glycol 6000 12g
Make 1000
Method for making: the meloxicam fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused polyethylene glycol 6000 substrate, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Two, example 2
Prescription:
Meloxicam 7.5g
Macrogol 4000 12g
Make 1000
Method for making: the meloxicam fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused Macrogol 4000 substrate, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Three, example 3
Prescription:
Meloxicam 7.5g
Polyethylene glycol 6000 2g
Macrogol 4000 10g
Make 1000
Method for making: the meloxicam fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in fused Macrogol 4000 and the polyethylene glycol 6000 mixed-matrix, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Four, example 4
Prescription:
Meloxicam 7.5g
Glyceryl monostearate 12g
Make 1000
Method for making: the meloxicam fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused glyceryl monostearate substrate, and mixing is a coolant with the frozen water, the dropping preparation method pill, and drying, promptly.
Five, example 5
Prescription:
Meloxicam 7.5g
Polyethylene glycol 6000 10g
Poloxamer 2g
Make 1000
Method for making: the meloxicam fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in fused polyethylene glycol 6000 and the poloxamer mixed-matrix, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Six, example 6
Prescription:
Meloxicam 7.5g
Glyceryl monostearate 11g
Poloxamer 1g
Make 1000
Method for making: get the mixing fine powders that meloxicam and poloxamer cross 200 mesh sieves through micronizing and be added in the fused glyceryl monostearate substrate, mixing is a coolant with the frozen water, the dropping preparation method pill, and drying, promptly.
Claims (4)
1. meloxicam drop pill and preparation method thereof is characterized in that: the meloxicam fine powder of 1 weight portion through micronizing is added in 1～10 weight portion molten matrix, and abundant mixing, dropping preparation method is condensed into ball in coolant, remove coolant, drying, promptly.
2. the structural formula of the described meloxicam Meloxicam of claim 1 is
3. the described substrate of claim 1 includes but not limited to polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, cetomacrogol 1000, sodium stearate, glycerin gelatine, poloxamer, stearic acid, glycerol monostearate acid, insect wax etc.
4. the described coolant of claim 1 includes but not limited to dimethicone, liquid paraffin, vegetable oil, water, alcoholic solution etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200310121922XA CN1546034A (en) | 2003-12-08 | 2003-12-08 | Dripping pills of meloxicam and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200310121922XA CN1546034A (en) | 2003-12-08 | 2003-12-08 | Dripping pills of meloxicam and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1546034A true CN1546034A (en) | 2004-11-17 |
Family
ID=34338573
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA200310121922XA Pending CN1546034A (en) | 2003-12-08 | 2003-12-08 | Dripping pills of meloxicam and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1546034A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013056684A2 (en) * | 2011-10-18 | 2013-04-25 | 华东理工大学 | Thiazole derivative as dhodh inhibitor and use thereof |
-
2003
- 2003-12-08 CN CNA200310121922XA patent/CN1546034A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013056684A2 (en) * | 2011-10-18 | 2013-04-25 | 华东理工大学 | Thiazole derivative as dhodh inhibitor and use thereof |
| WO2013056684A3 (en) * | 2011-10-18 | 2013-06-13 | 华东理工大学 | Thiazole derivative as dhodh inhibitor and use thereof |
| CN103998434A (en) * | 2011-10-18 | 2014-08-20 | 华东理工大学 | Thiazole derivative as DHODH inhibitor and use thereof |
| CN103998434B (en) * | 2011-10-18 | 2016-10-12 | 华东理工大学 | Thiazole and application thereof as DHODH inhibitor |
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|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |