CN1596731A - Multibauteria substance and its preparation method - Google Patents

Abstract

A multibacteria substance with medical function is prepared from 29 Chinese-emdicinal materials including cordyceps, liquorice root, astragalus root, cinammon bark, etc through fermenting.

Description

A kind of ROUZHI thalluses and preparation method thereof

Technical field:

The present invention relates to biotechnology, a kind of ROUZHI thalluses that obtains by the fermentation of Chinese herbal medicine is provided especially.

Background technology:

" Ganoderma " is " elixir " that Emperor Qin seeks in the legend, is called as " meat sesame " in the record of Ancient Times in China document.In the ancient books " meat sesame " and other Ganoderma are mentioned in the same breath, indicate that it is nontoxic, function [curing mainly]: make people " it is not old to make light of one's life by commiting suicide, and the angle prolongs life ", be decided to be " top grade ".

(1) " China book on Chinese herbal medicine " (annotate: this book is contemporary authoritative document, by the chief editor of editorial board of State Administration of Traditional Chinese Medicine's " China's book on Chinese herbal medicine ", claim in the book: " " detailed outline " (annotating: refer to Compendium of Material Medica) quoted as proof the record of relevant Ganoderma class of successive dynasties, and proposed the opinion of oneself.Say: the sesame class is a lot of ... its kind can not be failed to see." The Master of Preserving Simplicity " (annotate: cloud Jin Daige flood work): " sesame has SHIZHI, wooden sesame, careless sesame, meat sesame, bacterium sesame, and is all also hundreds of." sesame of Ancient Times in China record, kind more complicated be described " (drawing from " China's book on Chinese herbal medicine " 169 pages of " Ganoderma " projects of the de luxe edition first volume).

(2) roll up under the item of " SHIZHI " in SHIBU the 9th in Compendium of Material Medica ([bright] Li Shizhen (1518-1593 A.D.) work) book, all drawing " The Master of Preserving Simplicity " down with the item of dish portion the 28 volume " sesame " is described as " meat sesame " form: " meat sesame shape such as meat; invest Da Shi have end to end, be biology also.Red person such as Corallium Japonicum Kishinouye, white person deceives person such as Herba Euphorbiae Helioscopiae as cutting fat, blue or green person such as emerald green plumage, yellow person such as Zijin, all light is understood thoroughly as black ice also.Jin surplus the big person ten, three or four jin of little persons.Function [curing mainly]: smash the end, or change the water clothes, make us making light of one's life by commiting suicide, alive for evermore." (drawing from 577 pages of the Compendium of Material Medica first volumes, volume two 1708-1709 page or leaf).

(3) also quote " The Master of Preserving Simplicity " argumentation (seeing the seven 411-412 pages or leaves of " food book on Chinese herbal medicine " volume, 21 1334-1336 pages or leaves of volume) in " food book on Chinese herbal medicine " ([bright] Yao Kecheng compiles) book as proof about " meat sesame ".

Also there is the report of discovery " Ganoderma " in China only a few area, and people go after in a swarm, and regard as " superb work alive for evermore ".According to domestic document announcement: the U.S. found the natural materials of a kind of being commonly called as " Ganoderma " (or meat sesame) in 1973, owing to be not good at certainly at that time, only lived for three weeks.At home since nineteen ninety-two, successively in Shaanxi Province, ground such as Hebei province, three provinces in the northeast of China also found similar natural materials.Through this material of relevant expert's identification and analysis is a kind of protoplast biology between protozoa and fungus, has both had the protozoacide characteristics, and the characteristics of fungus are also arranged.

Chinese patent ZL96118007.2 had once reported a kind of Poria of using, Radix Glycyrrhizae, Fructus Jujubae, Fructus Lycii, Fructus Mori, Semen Coicis, Arillus Longan, Fructus Crataegi, Semen Nelumbinis, Carapax et Plastrum Testudinis, Zaocys, fish maw, Cordyceps, Mel, Monas cuspurpureus Went, the fungus complex of similar " meatball " of the long-term fermenting process of preparing of syrup and water warp of really crawling, has more rich food nutrient composition, help the balance function of human body, strengthen body immunity, can play certain therapeutical effect to some cancer patient, but the compound many thalline of this kind, the preparation process complexity, need 3 years ability of fermentation to obtain required compound many thalline, production cycle is long, and therapeutic effect can not be fully up to expectations.

Summary of the invention:

The object of the present invention is to provide a kind of ROUZHI thalluses, these many thalline have better therapeutic effect, and preparation process is simple, and are with short production cycle.

The invention provides a kind of ROUZHI thalluses, it is characterized in that: this ROUZHI thalluses is to be Poria 200～300g by filling a prescription, Cordyceps 10～20g, Lasiosphaera Seu Calvatia 50～70g, Herba Artemisiae Annuae 450～550g, Radix Rehmanniae Preparata 50～70g, Radix Polygalae 25～35g, the Rhizoma Atractylodis Macrocephalae 50～70g, Radix Pseudostellariae 10～20g, Radix Glycyrrhizae 50～70g, the Radix Astragali 40～60g, Radix Aconiti Lateralis Preparata 5～15g, Ramulus Cinnamomi 50～70g, Herba Epimedii 40～60g, Radix Morindae Officinalis 25～35g, Rhizoma Polygonati 50～70g, Radix Ophiopogonis 50～70g, Rhizoma Polygonati Odorati 50～70g, Fructus Schisandrae Chinensis 25～35g, Fructus Trichosanthis 40～60g, Pericarpium Citri Reticulatae 50～70g, Radix Arnebiae (Radix Lithospermi) 10～20, Periostracum Cicadae 40～60g, Fructus Jujubae 50～70g, Rhizoma Dioscoreae 400～600g, Fructus Rosae Laevigatae 1500～2500g, fructus zizaniae caduciflorae 1500～2500g, Mel 1500～2500g, Massa Medicata Fermentata is an amount of, the Chinese herbal medicine of Fructus Hordei Germinatus 400～600g obtains through fermentation.

In the ROUZHI thalluses of the present invention, when adopting prescription to be: during an amount of, the Fructus Hordei Germinatus 500g of Poria 240g, Cordyceps 15g, Lasiosphaera Seu Calvatia 60g, Herba Artemisiae Annuae 500, Radix Rehmanniae Preparata 60g, Radix Polygalae 30g, Rhizoma Atractylodis Macrocephalae 60g, Radix Pseudostellariae 15g, Radix Glycyrrhizae 60g, Radix Astragali 50g, Radix Aconiti Lateralis Preparata 10g, Ramulus Cinnamomi 60g, Herba Epimedii 50g, Radix Morindae Officinalis 30g, Rhizoma Polygonati 60g, Radix Ophiopogonis 60g, Rhizoma Polygonati Odorati 60g, Fructus Schisandrae Chinensis 30g, Fructus Trichosanthis 50g, Pericarpium Citri Reticulatae 60g, Radix Arnebiae (Radix Lithospermi) 15g, Periostracum Cicadae 50g, Fructus Jujubae 60g, Rhizoma Dioscoreae 500g, Fructus Rosae Laevigatae 1000g, fructus zizaniae caduciflorae 1000g, Mel 1000g, Massa Medicata Fermentata, best results.

The present invention also provides the preparation method of above-mentioned ROUZHI thalluses, it is characterized in that step is as follows:

A selects fine Poria, Cordyceps, Lasiosphaera Seu Calvatia, Herba Artemisiae Annuae, Radix Rehmanniae Preparata, Radix Polygalae, the Rhizoma Atractylodis Macrocephalae, Radix Pseudostellariae, Radix Glycyrrhizae, the Radix Astragali, Radix Aconiti Lateralis Preparata, Ramulus Cinnamomi, celestial spirit, Radix Morindae Officinalis, Rhizoma Polygonati, Radix Ophiopogonis, Rhizoma Polygonati Odorati, Fructus Schisandrae Chinensis, Fructus Trichosanthis, Pericarpium Citri Reticulatae, Radix Arnebiae (Radix Lithospermi), Periostracum Cicadae, Fructus Jujubae, Rhizoma Dioscoreae, Fructus Rosae Laevigatae, fructus zizaniae caduciflorae, Fructus Hordei Germinatus, through washing, standby after the infusion;

The B steeping in wine takes out standby after three days;

The C steaming and decocting picks up counting with boiling point, takes out, and cools off standby in 10～30 minutes;

D fermentation is put into container with well-done medicine and is added Mel, Massa Medicata Fermentata, sealing, and opening in per then 5～10 days once provides air and adds Mel, just can grow ROUZHI thalluses after three months.

In the preparation method of ROUZHI thalluses of the present invention, when fermentation temperature is controlled at the 25 degree left and right sides, thalline is grown fast.

ROUZHI thalluses form of the present invention has coralliform, meat shape, fatty shape, Hepar Bovis seu Bubali shape etc.; Smooth surface is thoroughly just like black ice; Layering is obvious; The meat exquisiteness, high resilience; After breaking away from nutritional solution, place under the point-blank condition of high temperature and high light many days not putrid and deteriorated; Deposit the back non-inactivation in subzero ten octave freezings; It is strong that antifungal pollutes power.ROUZHI thalluses of the present invention by analysis mainly is made up of glue acetobacter, yeast, lactobacillus, four kinds of microorganisms of letter stalk born of the same parents bacterium.Contain a large amount of protein, nucleic acid and multivitamin and human body trace elements necessary.No acute or chronic toxicity.ROUZHI thalluses of the present invention has the adjustment human circulation, and balance function of human body and strengthen the function of body immunity can SOD in vivo enhancement, reduce LPO, to anti-ageing good action is arranged, and has abundant nutritive value and good medicinal curative effect.ROUZHI thalluses of the present invention is compared with Chinese patent ZL96118007.2, in treatment at malignant tumor, onset is faster, act on more obvious, and ROUZHI thalluses of the present invention is in the preparation, can obtain medicine direct fermentation, economization a plurality of extraction steps, particularly fermentation time is short, thereby can reduce production cost greatly.

The specific embodiment:

The embodiment of the invention does not limit the present invention.

Embodiment 1

Select fine Poria, Cordyceps, Lasiosphaera Seu Calvatia, Herba Artemisiae Annuae, Radix Rehmanniae Preparata, Radix Polygalae, the Rhizoma Atractylodis Macrocephalae, Radix Pseudostellariae, Radix Glycyrrhizae, the Radix Astragali, Radix Aconiti Lateralis Preparata, Ramulus Cinnamomi, celestial spirit, Radix Morindae Officinalis, Rhizoma Polygonati, Radix Ophiopogonis, Rhizoma Polygonati Odorati, Fructus Schisandrae Chinensis, Fructus Trichosanthis, Pericarpium Citri Reticulatae, Radix Arnebiae (Radix Lithospermi), Periostracum Cicadae, Fructus Jujubae, Rhizoma Dioscoreae, Fructus Rosae Laevigatae, fructus zizaniae caduciflorae, Fructus Hordei Germinatus, the throwing amount is respectively: Poria 240g, Cordyceps 15g, Lasiosphaera Seu Calvatia 60g, Herba Artemisiae Annuae 500, Radix Rehmanniae Preparata 60g, Radix Polygalae 30g, Rhizoma Atractylodis Macrocephalae 60g, Radix Pseudostellariae 15g, Radix Glycyrrhizae 60g, Radix Astragali 50g, Radix Aconiti Lateralis Preparata 10g, Ramulus Cinnamomi 60g, Herba Epimedii 50g, Radix Morindae Officinalis 30g, Rhizoma Polygonati 60g, Radix Ophiopogonis 60g, Rhizoma Polygonati Odorati 60g, Fructus Schisandrae Chinensis 30g, Fructus Trichosanthis 50g, Pericarpium Citri Reticulatae 60g, Radix Arnebiae (Radix Lithospermi) 15g, Periostracum Cicadae 50g, Fructus Jujubae 60g, Rhizoma Dioscoreae 500g, Fructus Rosae Laevigatae 1000g, fructus zizaniae caduciflorae 1000g, Fructus Hordei Germinatus 500g, above-mentioned raw materials is washed infusion, take out after three days with soaking in Chinese liquor, begin in boiling point, cooling was taken out in steaming and decocting in 20 minutes, put into container and add Mel, Massa Medicata Fermentata seals in right amount, opening weekly then once provides air and adds Mel, promptly grows ROUZHI thalluses after three months.

Claims (4)

1, a kind of ROUZHI thalluses is characterized in that: this ROUZHI thalluses is to be Poria 200～300g by filling a prescription, Cordyceps 10～20g, Lasiosphaera Seu Calvatia 50～70g, Herba Artemisiae Annuae 450～550g, Radix Rehmanniae Preparata 50～70g, Radix Polygalae 25～35g, the Rhizoma Atractylodis Macrocephalae 50～70g, Radix Pseudostellariae 10～20g, Radix Glycyrrhizae 50～70g, the Radix Astragali 40～60g, Radix Aconiti Lateralis Preparata 5～15g, Ramulus Cinnamomi 50～70g, Herba Epimedii 40～60g, Radix Morindae Officinalis 25～35g, Rhizoma Polygonati 50～70g, Radix Ophiopogonis 50～70g, Rhizoma Polygonati Odorati 50～70g, Fructus Schisandrae Chinensis 25～35g, Fructus Trichosanthis 40～60g, Pericarpium Citri Reticulatae 50～70g, Radix Arnebiae (Radix Lithospermi) 10～20, Periostracum Cicadae 40～60g, Fructus Jujubae 50～70g, Rhizoma Dioscoreae 400～600g, Fructus Rosae Laevigatae 1500～2500g, fructus zizaniae caduciflorae 1500～2500g, Mel 1500～2500g, Massa Medicata Fermentata is an amount of, the Chinese herbal medicine of Fructus Hordei Germinatus 400～600g obtains through fermentation.

2,, it is characterized in that described prescription is according to the described ROUZHI thalluses of claim 1: Poria 240g, Cordyceps 15g, Lasiosphaera Seu Calvatia 60g, Herba Artemisiae Annuae 500, Radix Rehmanniae Preparata 60g, Radix Polygalae 30g, Rhizoma Atractylodis Macrocephalae 60g, Radix Pseudostellariae 15g, Radix Glycyrrhizae 60g, Radix Astragali 50g, Radix Aconiti Lateralis Preparata 10g, Ramulus Cinnamomi 60g, Herba Epimedii 50g, Radix Morindae Officinalis 30g, Rhizoma Polygonati 60g, Radix Ophiopogonis 60g, Rhizoma Polygonati Odorati 60g, Fructus Schisandrae Chinensis 30g, Fructus Trichosanthis 50g, Pericarpium Citri Reticulatae 60g, Radix Arnebiae (Radix Lithospermi) 15g, Periostracum Cicadae 50g, Fructus Jujubae 60g, Rhizoma Dioscoreae 500g, Fructus Rosae Laevigatae 1000g, fructus zizaniae caduciflorae 1000g, Mel 1000g, an amount of, the Fructus Hordei Germinatus 500g of Massa Medicata Fermentata.

3, the preparation method of a kind of claim 1 or 2 described ROUZHI thalluses is characterized in that step is as follows:

A selects fine Poria, Cordyceps, Lasiosphaera Seu Calvatia, Herba Artemisiae Annuae, Radix Rehmanniae Preparata, Radix Polygalae, the Rhizoma Atractylodis Macrocephalae, Radix Pseudostellariae, Radix Glycyrrhizae, the Radix Astragali, Radix Aconiti Lateralis Preparata, Ramulus Cinnamomi, Herba Epimedii, Radix Morindae Officinalis, Rhizoma Polygonati, Radix Ophiopogonis, Rhizoma Polygonati Odorati, Fructus Schisandrae Chinensis, Fructus Trichosanthis, Pericarpium Citri Reticulatae, Radix Arnebiae (Radix Lithospermi), Periostracum Cicadae, Fructus Jujubae, Rhizoma Dioscoreae, Fructus Rosae Laevigatae, fructus zizaniae caduciflorae, Fructus Hordei Germinatus, through washing, standby after the infusion;

The B steeping in wine takes out standby after three days;

The C steaming and decocting picks up counting with boiling point, takes out, and cools off standby in 10～30 minutes;

D fermentation is put into container with well-done medicine and is added Mel, Massa Medicata Fermentata, sealing, and opening in per then 5～10 days once provides air and adds Mel, just can grow ROUZHI thalluses after three months.

4,, it is characterized in that described fermentation temperature is controlled at 25 degree according to the preparation method of the described ROUZHI thalluses of claim 1.