CN1589872A

CN1589872A - Red date extract for treating alimentary malignant tumour

Info

Publication number: CN1589872A
Application number: CN 200410005625
Authority: CN
Inventors: 周宝义
Original assignee: Individual
Current assignee: Individual
Priority date: 2004-02-16
Filing date: 2004-02-16
Publication date: 2005-03-09

Abstract

A red jujube extract, cAMP capsule, for treating stomach cancer, cardia cancer, intestinal cancer, etc is prepared from red jujube as primary raw material through extracting, low-temp drying and superfine pulverizing.

Description

A kind of Fructus Jujubae extract for the treatment of malignant tumor of digestive tract

The technical field Chinese medicine preparation

Background technology is except acquired immune deficiency syndrome (AIDS) (AIDS), and malignant tumor is the most serious a kind of disease of present harm humans health, and the whole world has 6,000,000 people to die from malignant tumor every year approximately.At present, still lack satisfied Therapeutic Method and means.Therefore, tumor becomes increasingly conspicuous to the mankind's threat, has become great research topic in the current medical domain in the world.Though doctor trained in Western medicine is occupying leading position aspect the treatment tumor,, still can not underestimate to the negative effect that the patient brings.Inquire into the road of treatment malignant tumor from traditional Chinese medical science angle, and walked decades, still aspect oncotherapy, be in the dock.It is a lot of that Chinese and western medicine is inquired into the method for the treatment of tumor.At present, effective method for treatment can arrive sure and generally acknowledged deeply, or phoenix feathers and unicorn horns.At present, just in the ascendant with plant amedica treatment tumor in the world, be acknowledged as the most promising a kind of means of treatment tumor.So the inventor based on motherland's Traditional Chinese medical theory.On the basis of my patent " cell-differentiation inducers ", in addition with reference to and use for reference.Adopt modern Chinese medicine pharmacology and scientific achievement, utilization high-tech extractive technique is invented a kind of Fructus Jujubae extract " cAMP " capsule for the treatment of digestive tract tumor.

Summary of the invention one, preparation are formed: cAMP _225gGlutathion _15g

Two, the side separates: cAMP (adenosine cyclophosphate) in the side: be the active ingredient of extracting from the fruit of Rhamnaceae plant Fructus Jujubae zizi phusjuujba.Mill.Var.inefmis (Bge) Rchd..Be mainly used in treatment gastric cancer, carcinoma of gastric cardia, malignants tumor of digestive tract such as intestinal cancer.Modern pharmacological research proves: ((tube claims the single Vitamin B4 thuja acid of cyclisation: adenosine cyclophosphate) to contain abundant cAMP in the Fructus Jujubae.) cAMP content is lower in the tumor cell, if infiltrate the cAMP composition to tumor cell, can make some sensitivities, just the cancerous cell in malignant development stops hypertrophy, even makes it to transfer to normal cell.Leukocyte cAMP is increased, and can suppress the release of chemical mediator leukotriene LTD4.Experimental results show that: when the concerning of research cAMP and cancerous cell, find in the cultivation of multiple cancerous cell that behind the adding cAMP, growth of cancer cells is suppressed.When cultivating the 4th day, the inhibition degree reaches 70-80%.When add cAMP in culture fluid after, soon, cell just transforms to normal direction, obtains the normal fibroblast characteristic; Monolayer growth, resuming contacts property inhibition iuntercellular is arranged in parallel, and outer deformation is big.In form, all transform on function and the cell surface characteristic to normal aspect.Put down in writing in the document: also have many similar researchs, obtain same conclusions.Their metamorphosis under the optical microscope, biochemical change and ultramicroscope under the several aspects of microcell structural change prove: cAMP can make cancerous cell transform to Normocellular direction really.Glutathion: the active ingredient that is extraction the style (maize palpus) from Gramineae plant Semen Maydis zea.maysi..Modern pharmacological research proves: the anticancer factor-glutathion.Have stronger antioxidant capacity, carcinogen is lost activity.The mutual compatibility of two flavor extracts brings out the best in each other.Have anticancerly, antioxidant capacity stops the effect of cancer cell hyperplasia.

Three, pharmacological action:

(1), have the concentration that strengthens cAMP in the hemocyte, make it the cancerous cell differentiation and reach the effect of becoming a full member;

(2), the effect that has the release that suppresses chemical mediator leukotriene (LTD4);

(3), contain the anticancer factor, cancerous cell is had stronger antioxidant capacity, can make the deactivated effect of carcinogen;

Four, indication and function:

Be applicable to malignants tumor of digestive tract such as gastric cancer, carcinoma of gastric cardia, intestinal cancer.Function has anticancer, and antioxidant capacity stops tumor proliferative and diffusion.

Five, usage and consumption:

Oral capsule.Four times a day, each 5-7 grain; (the suggestion patient took medicine by the course of treatment.30 days is a course of treatment).

1., cAMP (adenosine cyclophosphate) specific embodiment one, preparation method:.Adopt the high-tech extractive technique extract to be separated out drying, coarse powder, standby.2., maize must extract---glutathion.Adopt the high-tech extractive technique, extract is separated out drying, coarse powder, standby.3. above extract is pressed the prescription weighing, used modern superfine powder technology processing then.4., sterilize dress 0# capsule.Every contains clean medicine 0.4 gram.Encapsulated approximately 600.

Two, dosage form and requirement: dosage form is a capsule.(also can be developed into tablet).Every contains clean medicine 0.4 gram (400 milligrams).

Three, taboo and reaction: experiment and clinical proof have no side effect.

Claims

1, a kind of pure Chinese medicinal preparation " cAMP capsule " for the treatment of malignants tumor of digestive tract such as gastric cancer, carcinoma of gastric cardia, intestinal cancer, it is characterized by: by Fructus Jujubae extract is that principal agent is formed.Extract active ingredient then.Dosage form is capsule (also can be developed into tablet).Every contains clean medicine 0.4g (400mg).

2, according to power 1 described Chinese medicine preparation.It is characterized by: adopt the high-tech extractive technique that effective components of Chinese medicinal is proposed.The processing of superfine powder technology is adopted in cold drying.Sterilization treatment is adorned capsule No. 0.Every contains clean medicine 0.4g

3, according to power 1 and 2 described Chinese medicine preparation.It is characterized by: adopt Fructus Jujubae extract-cAMP (adenosine cyclophosphate) and maize palpus extract-glutathion, be used as medicine as composition in the prescription.Malignants tumor of digestive tract such as treatment gastric cancer, carcinoma of gastric cardia, intestinal cancer.