CN1583016A - Kebiting preparation for relieving cough and its preparing method - Google Patents
Kebiting preparation for relieving cough and its preparing method Download PDFInfo
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- CN1583016A CN1583016A CNA2004100207535A CN200410020753A CN1583016A CN 1583016 A CN1583016 A CN 1583016A CN A2004100207535 A CNA2004100207535 A CN A2004100207535A CN 200410020753 A CN200410020753 A CN 200410020753A CN 1583016 A CN1583016 A CN 1583016A
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Abstract
A Chinese medicine in the form of instant powder, particles, softgel, or tablet for treating caugh and asthma and resolving phlegm is prepared from white mustard seed, perilla seed and radish seed through proportional mixing, immersing in water, decocting, filtering, decocting dregs, collecting decoction, vacuum concentrating, filtering, recovering alcohol, concentrating, spray drying and shaping.
Description
Technical field:
The present invention relates to medical technical field, exactly it is a kind of Chinese medicine cough arresting---cough and must stop preparation and preparation method thereof.
Background technology:
Cough is a kind of common disease, and its pathogenic factor has multiple, can cause that cough can increase the weight of the state of an illness by diseases such as flu, pneumonia, tracheitiies, and violent cough can make patient very painful.The medicine of treatment cough at present has a variety of, and Chinese medicine is promptly arranged, and Western medicine is also arranged.China Patent No. 96109140 and 96118334 and 97100283 discloses the patent of invention that name is called " cough and asthma capsule ", " asthma curing plaster " and " a kind of Chinese patent medicine for the treatment of cough and asthma " respectively, and the compositions that they are made up of a lot of flavor Chinese medicines is used for taking orally or external application is treated cough.
Summary of the invention:
This purpose provides a kind ofly must stop preparation and preparation method thereof by coughing of forming of Semen Sinapis Albae, Fructus Perillae and Semen Raphani three flavor Chinese medicines, and it is mainly used in antitussive, removes expectorant, relievings asthma, and treats the cough that cold-phlegm causes.It is simple to have prescription, and therapeutic domain is wide, the characteristics of determined curative effect, and preparation technology is simple.
Semen Sinapis Albae among the present invention (semen sinapis) is the dry mature seed of crucifer Caulis et Folium Sinapis albee Sinapis alba L..Tap plant during fruit maturation at the beginning of autumn late summer, dry, lay seed, remove impurity.Semen Sinapis Albae is spherical in shape, diameter 1.5～2.5mm.The surface canescence is to faint yellow, and the reticulate pattern that tool is trickle has tangible point-like hilum.It is thin and crisp to plant skin, breaks the folding cotyledon of adularescent in the back, and oiliness is arranged.Odorless, acrid in the mouth is peppery.This product cross section: planting the skin surface is mucilage cell, and the mucus texture is arranged; Hypodermis is 2 row collenchymatous cells; Palisade cells 1 row, inwall and sidewall thicken, and outer wall is poor.Endosperm is the square cell of 1 row class, contains aleurone grain.Cotyledon and fatty oil droplet of radicle parenchyma cell and aleurone grain.Be used as medicine to fry Semen Sinapis (frying to buff according to the method for frying has fragrant peppery gas).Have warming the lung eliminating phlegm promoting the circulation of QI, the effect of resolving mass and removing the obstruction of the collateral pain relieving is used for cold-phlegm and breathes with cough, distending pain in the chest and hypochondrium, the expectorant meridians that stagnate, joint numbness pain, phlegm-damp fluidization tower.
Fructus Perillae is the dry mature fruit of labiate Folium Perillae Perillafrutescens (L.) Britt..Gather during fruit maturation autumn, removes impurity, dries.This product is oval or class sphere, the about 1.5mm of diameter.Surface taupe brown or taupe have the mulberry reticulate pattern of little protuberance, and base portion is point slightly, and canescence point-like carpopodium trace is arranged.Peel is thin and crisp, easily crushing.The seed yellow-white is planted epithelium matter, cotyledon 2, and off-white color has oiliness.Crushing has fragrance, little suffering of distinguishing the flavor of.This preparation is with Fructus Perillae (parched) be used as medicine (frying to detonans is arranged according to the method for frying).The effect of intestine moistening is relievingd asthma in the expectorant of this product tool sending down the abnormal ascending QI.Be used for expectorant and stop up QI rising in reverse order, cough and asthma, dryness of the intestine constipation.
Semen Raphani is the dry mature seed of crucifer Radix Raphani (Raphanus sativus L.), and tap plant during fruit maturation summer, dries, and rubs seed, removes impurity, dries again.This product is class oval or ellipse, and is flat slightly, long 2.5～4mm, wide 2～3mm.Surface yellowish-brown rufous or taupe brown.One end has the circular swollen umbilicus of dark-brown, and a side has several longitudinal furrows.It is thin and crisp to plant skin, cotyledon 2, and yellow-white has oiliness.Odorless, lightly seasoned little toil.This product differentiates with thin layer chromatography, with Semen Raphani (parched) be used as medicine (frying to little heaving according to frying method).This product tool helps digestion to remove and expands the effect of lowering the adverse-rising QI to resolve phlegm.Be used for retention of food and drink, constipation, stagnant dysentery, the expectorant heap soil or fertilizer over and around the roots is breathed with cough.
The present invention is that monarch drug and group are wanted composition by Semen Sinapis Albae, Fructus Perillae and Semen Raphani three flavor Chinese medicines, the medicine of the cough that be used to prepare antitussive, remove expectorant, relieving asthma, cold-phlegm causes.The proportion of composing of Semen Sinapis Albae, Fructus Perillae and Semen Raphani is 9: 9: 6.
Advantage of the present invention is that prescription is simple, prepares easily, has given full play to the function of Semen Sinapis Albae, Fructus Perillae and Semen Raphani three flavor treatments by Chinese herbs coughs in the prescription, has curative effect preferably.
The specific embodiment:
Embodiment 1
Cough and to stop electuary and preparation method thereof
Prescription
Cough and to stop electuary
Kebitingchongji
Semen Sinapis Albae (9000g) Fructus Perillae (9000g) Semen Raphani (6000g)
Make 1000 bags
Preparation method 1
Take by weighing Semen Sinapis Albae, Fructus Perillae and the Semen Raphani (all passing through parch) of recipe quantity, add the water retting 12 hours of 8 times of amounts, heat back to heat up in a steamer and decocted the leaching medicinal liquid 2 hours.Medicinal residues add the water of 6 times of amounts, heat back to heat up in a steamer and decocted 2 hours, filter, merge the secondary decocting liquid, being evaporated to density is 1.05～1.15 (90～95 ℃ of heat are surveyed), puts cold, add ethanol to pure content 75%, placed 12 hours, and filtered, filtrate recycling ethanol is not distinguished the flavor of to there being alcohol, and be concentrated to density be 1.17～1.30 thick paste (about 1800mL) of (90～95 ℃ of heat are surveyed), above-mentioned thick paste is 1 part, adds the dextrin of 0.8 part beta cyclodextrin, 1 portion of sucrose and 3 parts, mixing, granulate, dry (being about 10000g), be packaged into 1000 bags promptly, every bag of 10g.
Preparation method 2
Take by weighing Semen Sinapis Albae, Fructus Perillae and the Semen Raphani (all passing through parch) of recipe quantity, add the water retting 12 hours of 8 times of amounts, heat back to heat up in a steamer and decocted the leaching medicinal liquid 2 hours.Medicinal residues add the water of 6 times of amounts, heat back to heat up in a steamer and decocted 2 hours, filter, merge the secondary decocting liquid, being evaporated to density is 1.05～1.15 (90～95 ℃ of heat are surveyed), put cold, add ethanol to pure content 75%, placed 12 hours, filter, filtrate recycling ethanol is not distinguished the flavor of to there being alcohol, and be concentrated to the thick paste (about 1800mL) that density is 1.17～1.20 (90～95 ℃ of heat are surveyed), and above-mentioned thick paste is carried out spray drying (getting the about 1500g of dry powder), add 0.96 part beta cyclodextrin, 1.16 the dextrin of portion sucrose and 3.53 parts, mixing, it is an amount of to add water, granulates dry (being about 10000g), be packaged into 1000 bags promptly, every bag of 10g.
Embodiment 2
Cough and to stop granule and preparation method thereof
Prescription
Cough and to stop granule
Kebitingkeliji
Semen Sinapis Albae (3000g) Fructus Perillae (3000g) Semen Raphani (2000g)
Make 1000
Preparation method
Take by weighing Semen Sinapis Albae, Fructus Perillae and the Semen Raphani (all passing through parch) of recipe quantity, add the water retting 12 hours of 8 times of amounts, heat back to heat up in a steamer and decocted the leaching medicinal liquid 2 hours.Medicinal residues add the water of 6 times of amounts, heat back to heat up in a steamer and decocted 2 hours, filter, merge the secondary decocting liquid, be evaporated to density and be 1.05～1.15 (90～95 ℃ of heat are surveyed), put coldly, add ethanol to pure content 75%, placed 12 hours, filter, filtrate recycling ethanol is not distinguished the flavor of to there being alcohol, and be concentrated to the thick paste (about 650mL) that density is 1.17～1.30 (65 ℃ of heat are surveyed), above-mentioned thick paste is carried out spray drying (getting the about 500g of dry powder), add 80% alcoholic solution 60mL 10% acrylic resin I number, stirred 9 minutes, and added the 2.5g magnesium stearate, make granule, in 60 ℃ of oven dry, dress up 1000 capsules.
Embodiment 3
Cough and to stop soft capsule and preparation method thereof
Prescription
Cough and to stop soft capsule
Kebitingruanjiaonang
Semen Sinapis Albae (1500g) Fructus Perillae (1500g) Semen Raphani (1000g)
Get the 300ml clear paste after the extraction
Clear paste 300ml
PEG400 140g
Glycerol 12.5g
Tween 80 0.1g
Make 1000
Preparation method takes by weighing Semen Sinapis Albae, Fructus Perillae and the Semen Raphani (all passing through parch) of recipe quantity, adds the water retting 12 hours of 8 times of amounts, heats back to heat up in a steamer to decoct the leaching medicinal liquid 2 hours.Medicinal residues add the water of 6 times of amounts, heat back to heat up in a steamer and decocted 2 hours, filter, merge the secondary decocting liquid, being evaporated to density is 1.05～1.15 (90～95 ℃ of heat are surveyed), puts cold, add ethanol to pure content 75%, placed 12 hours, and filtered, filtrate recycling ethanol is not distinguished the flavor of to there being alcohol, and be concentrated to density be 1.17～1.30 thick paste (about 300mL) of (65 ℃ of heat are surveyed), in above-mentioned thick paste, add the Tween 80 mix homogeneously of recipe quantity, with homogenize machine homogenize 10 minutes, other adds the glycerol of recipe quantity, PEG400, solid dry powder, mixing with homogenize machine homogenize 30 minutes, is made 1000 soft capsules promptly.
Embodiment 4
Cough and to stop sheet and preparation method thereof
Prescription
Cough and to stop sheet
Kebitingpian
Semen Sinapis Albae (2250g) Fructus Perillae (2250g) Semen Raphani (1500g)
Make 1000
Preparation technology
Take by weighing Semen Sinapis Albae, Fructus Perillae and the Semen Raphani (all passing through parch) of recipe quantity, add the water retting 12 hours of 8 times of amounts, heat back to heat up in a steamer and decocted the leaching medicinal liquid 2 hours.Medicinal residues add the water of 6 times of amounts, heat back to heat up in a steamer to decoct 2 hours, filter, and merge the secondary decocting liquid, be evaporated to density and be 1.05～1.15 (90～95 ℃ of heat are surveyed), put coldly, add ethanol, placed 12 hours to pure content 75%, filter, filtrate recycling ethanol is not distinguished the flavor of to there being alcohol, and be concentrated to the thick paste (about 400mL) that density is 1.17～1.30 (90～95 ℃ of heat are surveyed), add beta-schardinger dextrin-50g, starch 70g, magnesium stearate 2.5g, mixing is made granule, drying, tabletting, sugar coating, promptly.
Claims (6)
1, cough and must stop preparation, it is characterized in that: it is that monarch drug and group are wanted composition by Semen Sinapis Albae, Fructus Perillae and Semen Raphani three flavor Chinese medicines, the preparation of the medicine of the cough that be used to prepare antitussive, remove expectorant, relieving asthma, cold-phlegm causes.
2, according to claim 1 coughing must be stopped preparation, it is characterized in that: the proportion of composing of Semen Sinapis Albae, Fructus Perillae and Semen Raphani is 9: 9: 6 in the medicine.
3, according to claim 1 coughing must be stopped preparation, it is characterized in that: described preparation is electuary, granule, soft capsule and tablet.
4, a kind of preparation method that must stop preparation of coughing as claimed in claim 1 is characterized in that: take by weighing Semen Sinapis Albae, Fructus Perillae and Semen Raphani through parch respectively by recipe quantity, add the water retting 12 hours of octuple amount, heat back and heat up in a steamer decoction 2 hours, leaching medicinal liquid.Medicinal residues add the water of 6 times of amounts, heat back to heat up in a steamer to decoct 2 hours, filter, merge the secondary decocting liquid, be evaporated to that density is 1.05～1.15 when 90～95 ℃ of heat are surveyed, put cold, add ethanol content 75%, placed 12 hours, and filtered, filtrate recycling ethanol is not distinguished the flavor of to there being alcohol, and to be concentrated into when 90～95 ℃ of heat are surveyed density be 1.17～1.30 thick paste, above-mentioned thick paste is carried out adding beta cyclodextrin, sucrose and dextrin again after the spray drying, add water and granulate drying; Or add 10% acrylic resin I number, 80% alcoholic solution stirs, and adds magnesium stearate and granulates.
5, the preparation method that to stop preparation of coughing according to claim 4, it is characterized in that: when above-mentioned 65 ℃ of heat are surveyed, be concentrated to density and be in 1.17～1.30 the thick paste, add the Tween 80 mix homogeneously, with homogenize machine homogenize 10 minutes, adding glycerol, PEG400, solid dry powder, mixing, with homogenize agent homogenize 30 minutes, make soft capsule.
6, the preparation method that must stop preparation of coughing according to claim 4 is characterized in that: add beta cyclodextrin, starch and magnesium stearate mixing in above-mentioned thick paste, make granule, drying, tabletting.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2004100207535A CN1583016A (en) | 2004-06-15 | 2004-06-15 | Kebiting preparation for relieving cough and its preparing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2004100207535A CN1583016A (en) | 2004-06-15 | 2004-06-15 | Kebiting preparation for relieving cough and its preparing method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1583016A true CN1583016A (en) | 2005-02-23 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2004100207535A Pending CN1583016A (en) | 2004-06-15 | 2004-06-15 | Kebiting preparation for relieving cough and its preparing method |
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| CN (1) | CN1583016A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7569237B2 (en) * | 2006-09-15 | 2009-08-04 | Luay Rashan | Composition for enhancing male fertility |
| CN103330758A (en) * | 2013-07-11 | 2013-10-02 | 康美药业股份有限公司 | Peony and liquorice soup formula granule, preparation method and detection method of peony and liquorice soup formula granule |
| CN107582626A (en) * | 2017-10-17 | 2018-01-16 | 朱晓军 | The cough and asthma that disappears phlegm wet dissipates preparation method |
-
2004
- 2004-06-15 CN CNA2004100207535A patent/CN1583016A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7569237B2 (en) * | 2006-09-15 | 2009-08-04 | Luay Rashan | Composition for enhancing male fertility |
| CN103330758A (en) * | 2013-07-11 | 2013-10-02 | 康美药业股份有限公司 | Peony and liquorice soup formula granule, preparation method and detection method of peony and liquorice soup formula granule |
| CN107582626A (en) * | 2017-10-17 | 2018-01-16 | 朱晓军 | The cough and asthma that disappears phlegm wet dissipates preparation method |
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