CN1562335A - Essential oil of ganoderma lucidum spore and preparation technique - Google Patents
Essential oil of ganoderma lucidum spore and preparation technique Download PDFInfo
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- CN1562335A CN1562335A CNA2004100176382A CN200410017638A CN1562335A CN 1562335 A CN1562335 A CN 1562335A CN A2004100176382 A CNA2004100176382 A CN A2004100176382A CN 200410017638 A CN200410017638 A CN 200410017638A CN 1562335 A CN1562335 A CN 1562335A
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- ganoderma
- spore
- quintessence oil
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- extraction
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Abstract
A refined oil of ganoderma spore is prepared from the red ganodermal spora through pulverizing for breaking wall, loading in extracting tank, introducing supercritical CO2, extracting, laying aside, separating oil from water, and filtering the oil.
Description
One, technical field:
The present invention discloses a kind of Ganoderma spore quintessence oil and preparation technology thereof, and its product can be applicable to medicine, food and the cosmetic field of new drug research and health food exploitation.
Two, background technology:
Ganoderma is the king of BAICAO, among the peoplely looks Ganoderma for " the miraculous cure elixir of life ".It has immunomodulating, antitumor, life lengthening, defying age, keep fit the effect of body.
Ganoderma spore is the elite of Ganoderma, it is the female and male gametophyte that Ganoderma raises up seed, contain effective active compositions such as a large amount of polysaccharides, triterpenes (Ganodenic acid etc.), polypeptide class what the Ganoderma development later stage discharged, effect is tens of times of Ganoderma sporophore, one ton of dry Ganoderma sporophore just contains one kilogram of spore powder, and as seen it is rare and valuable.
If Ganoderma spore powder does not have broken wall treatment, the human absorptivity is low, improved absorbance and curative effect greatly behind the breaking cellular wall, be 2 times of spore powder with crushed sporoderm not, China's ganoderma extract, big fellow's sporoderm-broken Ganoderma spore electuary etc., though have many advantages at aspects such as curative effects, active component content is low, contains the triterpenes active substance in the gram spore powder with crushed sporoderm and only is tens milligrams.
According to Chinese Academy of Sciences's national patent technology (patent of invention number: 99123952.0) claim to adopt supercritical CO
2Abstraction technique gets spore oil and contains triterpenes active substance 200mg/g, yield is about 5%, though active component content has improved nearly 20 times than Ganoderma spore powder, wherein has following subject matter: 1, the active component triterpenes is also very not high, only is about 200mg/g; 2, yield is lower, only is about 5% of Ganoderma spore powder; 3, take place to dash jar through regular meeting in the extraction process, have potential safety hazard.
Three, summary of the invention:
At present at home, Ganoderma spore powder, spore oil cause extraction yield low owing to extraction process, abstraction technique, isolation technics etc. are not best, and powder is careful behind the main ganoderma lucidium spore powder wall breaking, CO
2Be difficult for evenly passing through, channel easily takes place, and the pressure height, easily extract not exclusively towards jar.
For solving existing defective workmanship, the present invention discloses a kind of Ganoderma spore quintessence oil and preparation technology thereof, adopts supercritical CO
2Extraction process is by choosing, be ground into Ganoderma spore powder the Ganoderma lucidum (Leyss. Ex Fr.) Karst. spore, the extractor of packing into extraction, obtain Ganoderma spore extract, place layering, separate and remove moisture, filter refining Ganoderma spore quintessence oil, it is characterized in that: the selection sporoderm-broken rate reaches the Ganoderma lucidum (Leyss. Ex Fr.) Karst. spore powder more than 99%; Extracting pressure 20Mpa～30Mpa, 60 ℃～70 ℃ of extraction temperature, 2～4 hours extraction time, extract secondary repeatedly.The triterpenes active substance is 200mg～500mg in every kairine Ganoderma lucidum spore quintessence oil.After Ganoderma spore quintessence oil is breaking trachytectum of glossy ganoderma, the Ganoderma elaboration that makes through the inventive method.The triterpenes activity substance content is only tens milligrams in every kairine Ganoderma lucidum spore powder, and contains triterpenes active substance 200mg～500mg in the every kairine Ganoderma lucidum spore of the present invention quintessence oil, is 20 times of Ganoderma spore powder.The present invention refining orange-yellow Ganoderma spore quintessence oil, yield reaches 10%～25%, and is higher 2～5 times than other patent extraction yields, can be used for the raw material of health food and PTS.
Four, the specific embodiment:
Ganoderma spore is through supercritical CO by spore powder with crushed sporoderm
2The product that obtains after the extraction, (1) selected Ganoderma lucidum (Leyss. Ex Fr.) Karst. breaking trachytectum powder, sporoderm-broken rate is more than 99%; (2) adopt orthogonal test 20Mpa～30Mpa extracting pressure, 60 ℃～70 ℃ extraction temperature, the extraction time is 2～4 hours, and the reextraction method; (3) done some major reforms on operating procedure, reached safe and efficient, the Ganoderma spore quintessence oil yield can be up to 10%～25%, and the triterpenes activity substance content reaches down 200mg/g～500mg/g, and water content is at orange-yellow transparent Ganoderma spore essential oil below 1%.
Low at yield, active component content is low, uneasy congruent problem, the present invention adopts orthogonal test method.Described orthogonal test method is meant that three factors in the technology are extracting pressure, temperature and time, and the result who obtains under a certain value does 9 tests continuously, as one-period, carries out several periodic tests, obtains experience data.
It is 20Mpa～30Mpa that the present invention obtains extracting pressure, 60 ℃～70 ℃ of extraction temperature, and the extraction time is 2～4 hours, and reextraction; In order to prevent to dash jar and to keep jar interior Ganoderma spore powder tinning even, CO
2Evenly pass through each several part, add the rustless steel pompon, the addition percent by volume is 30%～50%, and adds a cover filter paper covering, and can reach like this to make that the Ganoderma spore quintessence oil response rate reaches 10%～25%, every gram triterpenes active substance is the top grade Ganoderma spore quintessence oil of 200mg～500mg.
The technological process of extracting ganoderma spore essential oil of the present invention is as follows:
This utility model preparation technology obtains the quality testing of Ganoderma spore quintessence oil:
1) color shape: golden transparent oily liquids;
2) the fragrance sense of taste: have the peculiar fragrance of Ganoderma, flavor is extremely bitter;
3) refraction index (20 ℃) 1.4500～1.4700;
4) relative density (25/25 ℃) 0.8500～0.9500;
5) acid number mgKoh/g≤20;
6) arsenic (in A3) %≤0.0002;
7) heavy metal (in Pb) %≤0.001;
8) total triterpenes 200mg/g～500mg/g;
9) moisture is below 1%.
Embodiment 1:
According to above-mentioned, the selected Ganoderma lucidum (Leyss. Ex Fr.) Karst. breaking trachytectum powder extractor of packing into adds the rustless steel pompon, and addition is 35% of a Ganoderma spore powder volume, extracting pressure 25Mpa, extraction temperature is 65 ℃, and the extraction time is 3 hours, reextraction, place then and separate, separate and to remove moisture, filter refining orange-yellow oily liquid---Ganoderma spore quintessence oil, contain triterpenes active substance 220mg in every kairine Ganoderma lucidum spore quintessence oil.
Embodiment 2:
The amount that adds the rustless steel pompon in the extraction is 40% of a Ganoderma spore powder volume, extracting pressure 28Mpa, and extraction temperature is 68 ℃, and the extraction time is 3.5 hours, and every gram contains triterpenes active substance 250mg in the acquisition Ganoderma spore quintessence oil, and other are with example 1.
Embodiment 3:
The amount that adds the rustless steel pompon in the extraction is 50% of a Ganoderma spore powder volume, extracting pressure 30Mpa, and extraction temperature is 70 ℃, and the extraction time is 4 hours, and every gram contains triterpenes active substance 240mg in the acquisition Ganoderma spore quintessence oil, and other are with example 1.
Claims (5)
1. the preparation technology of a Ganoderma spore quintessence oil adopts supercritical CO
2Extraction process is by choosing, be ground into Ganoderma spore powder the Ganoderma lucidum (Leyss. Ex Fr.) Karst. spore, the extractor of packing into extraction, obtain Ganoderma spore extract, place layering, separate and remove moisture, filter refining Ganoderma spore quintessence oil, it is characterized in that: the selection sporoderm-broken rate reaches the Ganoderma lucidum (Leyss. Ex Fr.) Karst. spore powder more than 99%; Extracting pressure 20Mpa～30Mpa, 60 ℃～70 ℃ of extraction temperature, 2～4 hours extraction time, extract secondary repeatedly.
2. the preparation technology of Ganoderma spore quintessence oil according to claim 1 is characterized in that: when described Ganoderma spore powder is packed the extractor extraction into, also dope the rustless steel pompon simultaneously, the amount of doping percent by volume is 30%～50%, gets extractor and covers and add a cover filter paper.
3. the preparation technology of Ganoderma spore quintessence oil according to claim 1 and 2 is characterized in that: adopt supercritical CO
2Extracting ganoderma spore essential oil yield can be up to 10%～25%.
4. by the Ganoderma spore quintessence oil of claim 1 or 2 described preparation technologies' acquisitions, it is characterized in that: the triterpenes active substance is 200mg～500mg in every kairine Ganoderma lucidum spore quintessence oil.
5. Ganoderma spore quintessence oil according to claim 4 is characterized in that: product is to have the distinctive fragrance of Ganoderma, refraction index 1.4500～1.4700, relative density 0.8500～0.9500, the moisture orange-yellow transparent oily liquid below 1%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2004100176382A CN1562335A (en) | 2004-04-13 | 2004-04-13 | Essential oil of ganoderma lucidum spore and preparation technique |
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| CNA2004100176382A CN1562335A (en) | 2004-04-13 | 2004-04-13 | Essential oil of ganoderma lucidum spore and preparation technique |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100430082C (en) * | 2006-06-13 | 2008-11-05 | 上海永昊生物医药研究所 | Glossy ganoderma spore essential oil compound capsules and preparation thereof |
| CN102379906A (en) * | 2011-06-22 | 2012-03-21 | 南京中科药业有限公司 | Processing method of improving tumor resistance of ganoderma lucidum spore oil |
| CN104323978A (en) * | 2014-11-12 | 2015-02-04 | 福建春辉生物工程有限公司 | Compound essential oil for removing striae gravidarum |
| CN105886122A (en) * | 2014-12-08 | 2016-08-24 | 陈亚海 | Lucid ganoderma essential oil and preparation method thereof |
-
2004
- 2004-04-13 CN CNA2004100176382A patent/CN1562335A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100430082C (en) * | 2006-06-13 | 2008-11-05 | 上海永昊生物医药研究所 | Glossy ganoderma spore essential oil compound capsules and preparation thereof |
| CN102379906A (en) * | 2011-06-22 | 2012-03-21 | 南京中科药业有限公司 | Processing method of improving tumor resistance of ganoderma lucidum spore oil |
| CN104323978A (en) * | 2014-11-12 | 2015-02-04 | 福建春辉生物工程有限公司 | Compound essential oil for removing striae gravidarum |
| CN105886122A (en) * | 2014-12-08 | 2016-08-24 | 陈亚海 | Lucid ganoderma essential oil and preparation method thereof |
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