CN1561966A - Liquid wound plaster and its preparing method - Google Patents
Liquid wound plaster and its preparing method Download PDFInfo
- Publication number
- CN1561966A CN1561966A CN 200410031161 CN200410031161A CN1561966A CN 1561966 A CN1561966 A CN 1561966A CN 200410031161 CN200410031161 CN 200410031161 CN 200410031161 A CN200410031161 A CN 200410031161A CN 1561966 A CN1561966 A CN 1561966A
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- maifanitum
- nanometer silver
- liquid
- chitin
- ethanol
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Abstract
A liquid-state bandage for wound is prepared from polyvinyl alcohol acetal, silicone oil, chitin, alcohol, acetate, Ag nanoparticles, propanetriol, dibutyl ester, mint oil, Chinese medical stone powder and distilled water.
Description
Technical field
The present invention relates to a kind of Wound dressing, especially a kind of liquid bandage.In addition, the invention still further relates to the preparation method of this liquid bandage.
Background technology
At present, all there are some defectives in employed medical dressing such as the various bandage that is used for wound dressing in the prior art: existing bandage, as Chinese patent CN2479952Y and the disclosed nanometer silver wound plaster of CN2489751Y, form by gauze layer and the adhesive linkage that is fixed in the gauze layer outside often, during the wrapping wound gauze layer is placed on the wound, to place the peeling paper on the adhesive linkage to take off, bandage is fixed on the skin of wound outside by adhesive linkage, this bandage can not make the wound and the external world isolate fully, water or dust are arranged unavoidably by entering wound in the slit between dressing and the skin, tissue fluid on the wound, secretions etc. also can ooze out in bandage, thus, can cause traumatic infection and make the cicatrix of formation excessive.In addition, in order to play the effect to the wound bactericidal antiphlogistic, also have the medicine that is soaked with anti-inflammation in some bandages gauze layer wherein, the medical dressing of this pastille makes the patient produce anaphylaxis and drug resistance easily.Have, it all has certain specification various existing bandages again, lacks stronger adaptability for some privileged sites, the special wound of shape on the health.
Summary of the invention
The objective of the invention is to solve dressing of the prior art bad to wound with extraneous sealing, to the size of wound, position etc. can not fine adaptation problem and antibiotic property medicine wherein cause irritated and chemical sproof problem, a kind of have film property, water proofing property, breathability preferably are provided, both can prevent wound infection, promote wound healing, can not make the patient produce anaphylaxis and drug resistance again, can with the liquid bandage of the wound good conformity of any position, any size on the health.Another object of the present invention is to provide the preparation method of described liquid bandage.
The object of the present invention is achieved like this:
Liquid bandage provided by the invention is semimobile paste when not contacting with air, and its raw material is formed and proportioning is: (weight portion)
Pioloform, polyvinyl acetal 0.5-15 part silicone oil 1-3 part
Chitin 0.5-20 part ethanol 0.5-20 part
Acetone 0.5-5 part nanometer silver 1-5 part
Glycerol 0.5-3 part dibutyl ester 1-5 part
Oleum menthae 0.5-1 part Maifanitum powder 1-6 part
Distilled water 3-10 part
This prescription can be:
Pioloform, polyvinyl acetal 5-15 part silicone oil 1-3 part
Ethanol 2-20 part of chitin 0.5-2 part 75-95%
Acetone 1-5 part nanometer silver 1-5 part
Glycerol 1-3 part dibutyl ester 1-5 part
Oleum menthae 0.5-1 part Maifanitum powder 1-6 part
Distilled water 0.5-5 part
This prescription can also be:
Pioloform, polyvinyl acetal 0.5-2 part silicone oil 1-3 part
Ethanol 0.5-1 part of chitin 5-20 part 75-95%
Acetone 0.5-1 part nanometer silver 1-5 part
Glycerol 0.5-1 part dibutyl ester 1-5 part
Oleum menthae 0.5-1 part Maifanitum powder 1-5 part
Distilled water 3-10 part
Its preparation method is:
Operation 1: with Pioloform, polyvinyl acetal, concentration is that the ethanol, acetone, silicone oil, glycerol, dibutyl ester, Oleum menthae of 75-95 mixes to stir and makes basal liquid 1; Whipping temp is at 10 ℃-60 ℃, speed＞500 rev/min, generally at 500-1000 rev/min, and mixing time is 20-40 minute;
Operation 2: chitin powder, nanometer silver powder, Maifanitum powder and distilled water mixed stirred 20-40 minute, to make with the Maifanitum be the nanometer silver 2 of carrier in oven dry then; The temperature of oven dry is 100 ℃-200 ℃, and the normal pressure drying time is 30 minutes, and the granularity of chitin and Maifanitum is less than 800nm, and the granularity of nanometer silver is less than 100 nanometers.
Operation 3: basal liquid 1 limit is stirred to the nanometer silver 2 that wherein drops into the Maifanitum carrier in the limit, mixing speed is greater than 500 rev/mins, generally at 500-1000 rev/min, treat that the nanometer silver of whole Maifanitum carriers is thrown in the quick stirring in the back that finishes 20-40 minute, mixing speed is 600-1100 rev/min; At room temperature left standstill then 24-36 hour, and stirred fast 5-15 minute with 600-1100 rev/min mixing speed again, make with the Maifanitum be nanometer silver 2 and the basal liquid 1 mutual mixed dissolution of carrier even product.
The said goods poured in the flexible pipe get final product, extrude at any time during use, it is applied at the wound place, coating is come, so that wound is covered, after about a few minutes, mastic can form a rete on wound, the periphery of rete is combined closely with the skin of not hindering, and wound is isolated from the outside out.
Above-mentioned liquid bandage, the wherein each kind of effect that raw material is played in product is such:
Pioloform, polyvinyl acetal has the excellent high transparent of filming, elasticity, toughness, anti-highly basic, oil resistivity and pliability, be widely used in intermediate coat, baking vanish, woodcare paint, the printing-ink of automobile and building gummed safety glass in the prior art, has good then property in woodenware metallic, plastic cement, leather, glass art use, the solid that is used for electronic ceramics and printed circuit board (PCB), the waterproofing agent of the modification agent of PUR, paint, textile, fiber etc.It plays good filming function in this product.By ethanol Pioloform, polyvinyl acetal is dissolved, become waterproof, gas-pervious film forming liquid;
Glycerol and dibutyl ester are the film forming liquid thickening; Oleum menthae is an aromatic;
Nanometer silver is an antibacterial, and it has the anion (Ag of positive charge
+) being adsorbed in the surface by electronegative antibacterial, silver ion passes bacterial outer membrane, and the base in the Double helix of the intravital DNA of antibacterial is associated, and causes antibacterial forfeiture schizogamy ability, thereby reaches the effect of supression or kill bacteria;
The character of Maifanitum uniqueness is its super porous and rare many material compositions, and its porous can match in excellence or beauty with active carbon, and approximate according to its surface area of test and active carbon, its contained material composition is two over thousands of kinds nearly.Particularly complete to the organism beneficial trace elements, some are excessive then to the deleterious element of organism, and content has just neither too much nor too little.Maifanitum is widely used in the adsorbent filler in the water treatment procedure in the prior art, regulate water quality, improve the activity of water, the substrate that also is used for breeding, raising seedling, be mainly used in the growing and cultivation of plants such as flowers and fruits, vegetable, energy water conservation, guarantor's fertilizer, ventilation, diseases prevention provide plant growing required trace element; Also be used for feed additive, provide isostatic natural polybasic mineral to poultry.But also do not use it in the Wound dressing, in this bandage, Maifanitum has absorption, decomposes, removes various materials, as the effect of amine, chlorine, hydrargyrum, cadmium, cyanogen, Fructus Vins coccus, colon bacillus (comprising 0-157) and various antibacterials; In addition, Maifanitum also has a special and important effect, and the nanometer silver that plays bactericidal action in this product is easy to generate clustering phenomena, and it can make nanometer silver skewness in the mastic of this product.Add the Maifanitum powder, with distilled water pulverous chitin, Maifanitum and nanometer silver are mixed into paste, and then oven dry, it is coated to make nanometer silver be had a Maifanitum of micropore in this course, can prevent nanometer silver generation clustering phenomena effectively.
Chitin is the present edibility animal fiber of unique cation in the world, be widely used in industrial circle (as replacing plastics), agriculture field (fertilizer that does not need pesticide) in the prior art, cosmetic field (adjusting skin etc.), medicine, membrane material and other environmental protection, health field, both can suppress cancer, hepatopathy, diabetes, cholesterol reducing, the enhancing body immunity is arranged again, and a series of magical effects such as prevent to wear out.The chitin that adds in product of the present invention has the effect that promotes wound healing, and favourable to film property.
Therefore, liquid bandage provided by the invention has following characteristics:
1, can adsorb secretions and harmful substance on the human external wound and wound surface with Maifanitum effectively as the nanometer silver bandage of carrier, make wound pain alleviate, subside a swelling, stop blooding, also eliminated the external condition of bacteria living, thereby can prevent the wound surface inflammation, fester, the various materials that contained in this liquid bandage have sterilization, antibacterial, the effect that absorbs, decompose, remove harmful substance and promote wound healing, be used to cover postoperative wound, can reduce Complication included infection.Simultaneously, this liquid bandage does not make the patient produce anaphylaxis and chemical sproof material, and is safe.
2, except above-mentioned curative effect effect to wound, this liquid bandage also has than the more tangible advantage of hospital gauze, and this liquid bandage is being coated on the skin after the film forming, it has water-sealed effect, wound promptly can contact water after having applied this liquid bandage, no transudate.This liquid bandage is smooth in the film forming rear surface, no oiliness, and it is elaborate can not to be infected with clothing.Film forming has certain elasticity, and therefore the piecemeal activity that applies freely.This liquid bandage is not limited by wound size, shape, and is tight with skin attachement, so, can cover the special wound of shape at any privileged sites of human body.
3, this liquid bandage is stored in the flexible pipe, and is aseptic, do not have before using with regard to contaminated anxiety, and easy to carry, this advantage is more outstanding especially in the open air.Use also very conveniently, only this liquid bandage need be squeezed on wound, apply to open and get final product, and need not to fix adding adhesive tape.Therefore, this bandage is very suitable for various wound emergence therapeutics and Wound protection.This bandage lay take off also very convenient.
The specific embodiment
Embodiment 1:
Liquid bandage provided by the invention is semimobile paste when not contacting with air, and its raw material is formed and proportioning is: (weight portion)
3 parts of 15 parts of silicone oils of polyvinyl formal
18 parts of 1 part of medical ethanols of chitin
2 parts of 5 parts of nanometer silvers of acetone
3 parts of 3 parts of dibutyl esters of glycerol
1 part in 1 part of Maifanitum powder of Oleum menthae
0.5 part of distilled water
Its preparation method is:
Operation 1: with 15 parts of polyvinyl formals, purity is that 95% 3 parts of 3 parts of 3 parts of 5 parts in 18 parts of medical ethanols, acetone, silicone oils, glycerol, dibutyl esters, Oleum menthae mix for 1 part to stir and make basal liquid 1; Whipping temp 10 ℃-60 ℃,, speed is at 500 rev/mins, mixing time is 30 minutes;
Operation 2: be that 1 part in the Maifanitum powder of 2 parts of silver, 800 nanometers of 1 part of chitin, 100 nanometers of 800 nanometers and distilled water mix for 0.5 part and stirred 20-40 minute with granularity, to make with the Maifanitum be the nanometer silver 2 of carrier in oven dry then; The temperature of oven dry is 150 ℃, and the normal pressure drying time is 30 minutes, and the granularity of chitin and Maifanitum is 600-700nm, the granularity 60-100 nanometer of nanometer silver.
Operation 3: while stirring with basal liquid 1 to the nanometer silver 2 that wherein drops into the Maifanitum carrier, speed is at 500 rev/mins, the nanometer silver for the treatment of whole Maifanitum carriers is thrown in the back that finishes and was stirred 30 minutes fast, mixing speed is 800 rev/mins; At room temperature left standstill then 30 hours, stir fast again made in 10 minutes with the Maifanitum be nanometer silver 2 and the basal liquid 1 mutual mixed dissolution of carrier even product.It is inserted in the flexible pipe.
Ethanol in the present embodiment also can be 75% purity, uses the high more ethanol of purity, and it is fast more to be coated to the film forming speed of wound after drying, and in addition, alcoholic acid amount should be able to make the Pioloform, polyvinyl acetal dissolving.The consumption of distilled water is corresponding with the amount of nanometer silver, Maifanitum and chitin.
Embodiment 2:
Liquid bandage provided by the invention is semimobile paste when not contacting with air, and its raw material is formed and proportioning is: (weight portion)
1 part of 2 parts of silicone oil of polyvinyl acetal
1 part of 20 parts of medical ethanol of chitin
2 parts of 0.5 part of nanometer silvers of acetone
1 part of 0.5 part of dibutyl ester of glycerol
5 parts in 0.5 part of Maifanitum powder of Oleum menthae
10 parts of distilled water
Its preparation method is substantially the same manner as Example 1.
Embodiment 2 and embodiment 1 compare, and the amount of Pioloform, polyvinyl acetal wherein significantly reduces, and correspondingly, the also corresponding minimizing of consumption of ethanol replaces to have the chitin of better film forming characteristics equally.Correspondingly, the also corresponding increase of the consumption of distilled water.Its zest of the liquid bandage that present embodiment provides is littler.
The above is specific embodiments of the invention and the know-why used, and is any based on the equivalent transformation on the technical solution of the present invention basis, all belongs within the protection domain of the present invention.
Claims (9)
1, a kind of liquid bandage is semimobile paste when not contacting with air, and its raw material is formed and proportioning is: (weight portion)
Pioloform, polyvinyl acetal 0.5-15 part silicone oil 1-3 part
Chitin 0.5-20 part ethanol 0.5-20 part
Acetone 0.5-5 part nanometer silver 1-5 part
Glycerol 0.5-3 part dibutyl ester 1-5 part
Oleum menthae 0.5-1 part Maifanitum powder 1-6 part
Distilled water 3-10 part
2, liquid bandage according to claim 1 is characterized in that: described prescription is: (weight portion)
Pioloform, polyvinyl acetal 5-15 part silicone oil 1-3 part
Chitin 0.5-2 part ethanol 2-20 part
Acetone 1-5 part nanometer silver 1-5 part
Glycerol 1-3 part dibutyl ester 1-5 part
Oleum menthae 0.5-1 part Maifanitum powder 1-6 part
Distilled water 0.5-5 part
3, liquid bandage according to claim 1 is characterized in that: described prescription is: (weight portion)
Pioloform, polyvinyl acetal 0.5-2 part silicone oil 1-3 part
Chitin 5-20 part ethanol 0.5-1 part
Acetone 0.5-1 part nanometer silver 1-5 part
Glycerol 0.5-1 part dibutyl ester 1-5 part
Oleum menthae 0.5-1 part Maifanitum powder 1-5 part
Distilled water 3-10 part
4, according to the described liquid bandage of one of claim 1-3, it is characterized in that: described ethanol is medical ethanol, and its purity is 75-95%.
5, according to the described liquid bandage of one of claim 1-3, it is characterized in that: described Pioloform, polyvinyl acetal is polyvinyl formal, polyvinyl acetal, polyvinyl alcohol contract propionic aldehyde or polyvinyl butyral resin.
6, according to the described liquid bandage of one of claim 1-3, it is characterized in that: the granularity of described nanometer silver is less than 100 nanometers.
7,, according to the described liquid bandage of one of claim 1-3, it is characterized in that: the granularity of described Maifanitum and chitin is for less than 800 nanometers.
8, a kind of liquid bandage as claimed in claim 1, its preparation method is:
Operation 1: Pioloform, polyvinyl acetal, ethanol, acetone, silicone oil, glycerol, dibutyl ester, Oleum menthae are mixed stirring make basal liquid 1;
Operation 2: chitin, nanometer silver, Maifanitum powder and distilled water mixed stirred 20-40 minute, to make with the Maifanitum be the nanometer silver 2 of carrier in oven dry then; The temperature of described oven dry is 100 ℃-200 ℃, and the normal pressure drying time is 30 minutes.
Operation 3: basal liquid 1 limit is stirred to the nanometer silver 2 that wherein drops into the Maifanitum carrier in the limit, treats that the nanometer silver of whole Maifanitum carriers is thrown in the quick stirring in the back that finishes 20-40 minute; At room temperature left standstill then 24-36 hour, stir fast again made in 5-15 minute with the Maifanitum be nanometer silver 2 and the basal liquid 1 mutual mixed dissolution of carrier even product.
9, the preparation method of liquid bandage according to claim 8 is characterized in that: the mixing speed in the described operation 1,2 and 3 is 500-1000 rev/min, and the mixing speed that rapidity wherein stirs is 600-1100 rev/min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410031161 CN1216593C (en) | 2004-04-13 | 2004-04-13 | Liquid wound plaster and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410031161 CN1216593C (en) | 2004-04-13 | 2004-04-13 | Liquid wound plaster and its preparing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1561966A true CN1561966A (en) | 2005-01-12 |
| CN1216593C CN1216593C (en) | 2005-08-31 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410031161 Expired - Fee Related CN1216593C (en) | 2004-04-13 | 2004-04-13 | Liquid wound plaster and its preparing method |
Country Status (1)
| Country | Link |
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| CN (1) | CN1216593C (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100493612C (en) * | 2005-12-22 | 2009-06-03 | 李强 | Wound bandage and plaster |
| CN101920042A (en) * | 2010-07-16 | 2010-12-22 | 四川理工学院 | Liquid bandage and preparation method |
| CN102406959A (en) * | 2011-11-29 | 2012-04-11 | 江苏德达医药科技有限公司 | Liquid bandage containing povidone iodine and preparation method thereof |
| CN104548185A (en) * | 2015-02-10 | 2015-04-29 | 广州赛莱拉干细胞科技股份有限公司 | Liquid dressing and preparation method thereof |
| CN104784746A (en) * | 2015-04-02 | 2015-07-22 | 蚌埠市惠鸿电子科技有限公司 | Electronic band-aid |
| CN104826156A (en) * | 2015-04-02 | 2015-08-12 | 蚌埠市惠鸿电子科技有限公司 | Preparation formula of liquid bandaid |
| CN105288722A (en) * | 2015-11-13 | 2016-02-03 | 任宏 | Waterproof ventilating liquid adhesive bandage and preparation method thereof |
| CN112891616A (en) * | 2021-01-29 | 2021-06-04 | 周建大 | Chitosan sodium hyaluronate antibacterial liquid film and preparation method thereof |
-
2004
- 2004-04-13 CN CN 200410031161 patent/CN1216593C/en not_active Expired - Fee Related
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100493612C (en) * | 2005-12-22 | 2009-06-03 | 李强 | Wound bandage and plaster |
| CN101920042A (en) * | 2010-07-16 | 2010-12-22 | 四川理工学院 | Liquid bandage and preparation method |
| CN101920042B (en) * | 2010-07-16 | 2012-12-12 | 四川理工学院 | Liquid bandage and preparation method |
| CN102406959A (en) * | 2011-11-29 | 2012-04-11 | 江苏德达医药科技有限公司 | Liquid bandage containing povidone iodine and preparation method thereof |
| CN102406959B (en) * | 2011-11-29 | 2013-12-25 | 江苏德达医药科技有限公司 | Liquid bandage containing povidone iodine and preparation method thereof |
| CN104548185A (en) * | 2015-02-10 | 2015-04-29 | 广州赛莱拉干细胞科技股份有限公司 | Liquid dressing and preparation method thereof |
| CN104784746A (en) * | 2015-04-02 | 2015-07-22 | 蚌埠市惠鸿电子科技有限公司 | Electronic band-aid |
| CN104826156A (en) * | 2015-04-02 | 2015-08-12 | 蚌埠市惠鸿电子科技有限公司 | Preparation formula of liquid bandaid |
| CN105288722A (en) * | 2015-11-13 | 2016-02-03 | 任宏 | Waterproof ventilating liquid adhesive bandage and preparation method thereof |
| CN112891616A (en) * | 2021-01-29 | 2021-06-04 | 周建大 | Chitosan sodium hyaluronate antibacterial liquid film and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1216593C (en) | 2005-08-31 |
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