CN1555847A - Medicne for preventing and treating virus and its preparaton method - Google Patents
Medicne for preventing and treating virus and its preparaton method Download PDFInfo
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- CN1555847A CN1555847A CNA2004100000328A CN200410000032A CN1555847A CN 1555847 A CN1555847 A CN 1555847A CN A2004100000328 A CNA2004100000328 A CN A2004100000328A CN 200410000032 A CN200410000032 A CN 200410000032A CN 1555847 A CN1555847 A CN 1555847A
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- stock solution
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- fructus crataegi
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Abstract
A Chinese medicine for preventing and eliminating viruses, HPV, intractable fungus, bacteria, dermatologic virus and pathogenic bacteria is prepared from kernal of haw, rose flower, etc. Its advantages are high effect and no toxic by-effect.
Description
Technical field:
The present invention relates to human body skin venereal disease infection and intractable pathogenic bacteria, prevention and cure of viruses field.
Technical background:
The association area prior art mostly is chemical substance and chemical substance and plant extract through holding synthetic medicine of matchmaker and daily hygiene disinfecting, antimicrobial product at present, though these prior art products have certain antibiotic and sterilizing effect, but because of product contains chlorhexidine acetate, benzalkonium bromide, benzalkonium chloride, noxious substances such as aldehyde, skin there is stimulation, or anaphylaxis, human body there is certain toxicity, and environment caused certain pollution, with the pure natural extract as preventing and treating virus and daily hygiene disinfecting, antimicrobial product is very few, particularly at intractable Dermatology poison, the prevention effect of pathogenic bacteria is not obvious.
Summary of the invention:
The purpose of this invention is to provide a kind of control virus drugs and preparation method, it have to human papilloma virus (HPV) (AC) and various intractable fungus, antibacterial superpower lethal effect is arranged, and diseases prevention, the positive effect of curing the disease, and meet environmental protection, it comprises with Fructus Crataegi pit, Herba Houttuyniae, Herba portulacae, Flos Rosae Rugosae extract and combines with proportion, it is characterized in that: described a kind of control virus drugs and preparation method prescription are to produce stock solution respectively with Fructus Crataegi pit, Herba Houttuyniae, Herba portulacae, Flos Rosae Rugosae, aseptic subpackaged, form with the proportion formulated in combination.The process of producing of its stock solution is: select respectively, flushing with clean water is clean, adopts different temperature dry distilling extracting juices respectively, through distillation extraction, must concentrate stock solution through vacuum concentration, aseptic subpackaged preservation is stand-by.
The stock solution of described preparation can add that the preparation of an amount of distilled water is put on the skin, washed, spray is used at human papillomavirus (HPV) control (AC) or the beriberi of fungal infection, and the control of the microbial Dermatology of virosis.
The present invention reaches beneficial effect: 1, the present invention does not have the green control virus of any chemical addition agent for pure natural, pathogenic bacteria and sterilization medicinal liquid, normal skin there is not any damage, nontoxic to human body, have no side effect, the affected part can be put or be sprayed to using method outward on the skin, can thoroughly eradicate (AC) nongonococcal urethritis of human papillomavirus (HPV), urinary tract infection, gonorrhea, the genitals bleb is examined, pityrosporum furfur, mycoplasma, chlamydia, trichophyton, gonococcus and obstinate bacteria, pathogenic bacteria has superpower killing action, treatment function: can treat oral ulcer and oral mucosa, scald wound, dermatosis, beriberi, cure rate is up to more than 99%.2, the sterilization medicinal liquid with formulated in combination of the present invention can be used for the environment articles for washing, and this sterilization medicinal liquid is free from environmental pollution, and body surface leaves no trace, the Related product that contains chemical analysis that can replace present market to sell.3, can preserve down by normal room temperature, this product stability reaches, its mass conservation, and result of use is constant.4, carried out the confirmation of pharmacological toxicology Clinical detection through PLA Air Force General Hospital and disease prevention and control center, Beijing detection department: the reliable effect of this invention medicinal liquid.
The specific embodiment:
Below in conjunction with embodiment the specific embodiment of the invention is described: with Fructus Crataegi pit, Herba Houttuyniae, Herba portulacae, Flos Rosae Rugosae, produce stock solution respectively, aseptic subpackaged, form by different proportionings.The process of producing of its stock solution is for selecting respectively, flushing with clean water clean (the Fructus Crataegi pit needs pulverization process), then with raw material and water by 1: 1-1: 5 weight ratio is mixed, after soaking 4-10 hour, the raw material that soaks from packing gas retort into, is extracted feeding mouth, temperature at 95 ℃-100 ℃ to collect rough liquid, the rough liquid of collecting is carried out the secondary dry distilling again, temperature is 105 ℃-110 ℃, extract refined liquid through dry distilling, again refined liquid is carried out distillation extraction, temperature is 105 ℃-110 ℃, to collect stock solution, the stock solution collected is concentrated through multifunctional reaction still, temperature be 95 ℃-110 ℃ to collect concentrated stock solution, preserve stand-by.
The prescription of the specific embodiment is:
To collect stand-by concentrated stock solution, form by different proportionings (%):
Prescription one:
The Fructus Crataegi pit concentrates stock solution 15-50%
Herba Houttuyniae concentrates stock solution 20-50%
Flos Rosae Rugosae extract 0.1-0.5%
Distilled water surplus
Prescription two:
The Fructus Crataegi pit concentrates stock solution 10-25%
Herba portulacae concentrates stock solution 15-40%
Flos Rosae Rugosae extract 0.1-0.3%
Distilled water surplus
Quantitative distilled water or pure water are dropped in the reactor, to fully mix stirring after 5 minutes to 10 minutes in the quantitative haw berry nuclear extract material input still and in Herba Houttuyniae extract material and the Herba portulacae extract input still, left standstill 40 minutes after 5 minutes fully mixing stirring in the quantitative Flos Rosae Rugosae extract material input still, filter aseptic subpackaged sealing and preserve.Finished product is a light yellowish brown clear liquid liquid, can put or be sprayed at the affected part outward on the skin, and human papillomavirus (HPV) control (AC) is had specially good effect, is used for the treatment of Dermatology and intractable fungus, antibacterial, viral infection has remarkable therapeutical effect.
Experimental example 1:
Through PLA Air Force General Hospital's clinical experiment center this invention medicinal liquid being carried out clinical experiment detects:
1, one, test item: fluorescence quantitative polymerase chain reaction test.
Two, detect and estimate foundation: " disinfection technology standard ", " national Clinical Laboratory rule of operation ".
Three, test strain: the clinical chorista that cuts of human papillomavirus (HPV) wart body.
Four, method:, adopt fluorescence quantitative polymerase chain reaction test authentication method, the test triplicate from cutting the chopping of human papillomavirus (HPV) wart soma clinically.
Five, result: clinical human papillomavirus (HPV) the wart soma of getting off that cuts is shredded, add normal saline, get its lysate, the human papillomavirus of containing in this lysate (HPV) amount greatly, after putting into 4 ℃ of refrigerators and depositing 10 days, observe quantitative polyase chain reaction method (FQ-PCR), the test triplicate, test temperature is to carry out under the normal capacity, can not detect human papillomavirus (HPV) after 24 hours.
2, one, test item: quantitative sterile test.
Two, test strain: pityrosporum furfur clinical separation strain, three strains, trichophyton clinical separation strain, three strains.
Three, detect and estimate foundation: " disinfection technology standard " " national Clinical Laboratory rule of operation ".
Four, sterile test method; 20 ℃ of test temperatures, the test triplicate adopts quantitative sterile test authentication method.
Five, result; Under 20 ℃ of water bath condition, prove this invention medicinal liquid 20% diluent effect 10 minutes through three repeated trials qualification results, be 99.86% to the average kill ratio of pityrosporum furfur clinical separation strain.This invention medicinal liquid 20% diluent effect 10 minutes is 99.62% to the average kill ratio of trichophyton clinical separation strain.
Experimental example 2:
Through disease prevention and control center, Beijing at the detection of testing of this invention medicinal liquid:
1, acute skin irritation test report.
One, experiment purpose: detect stimulation/corrosiveness and the intensity of this medicinal liquid to laboratory animal skin.
Two, this invention medicinal liquid is directly used in experiment.
Three, laboratory animal: one grade of New Zealand 4 of rabbit of kind is female, body weight 2.0-2.5kg, and the experimental animal feeding ambient room temperature is 21 ℃, and relative humidity is 50%RH, and single cage is raised.
Four, test method: select 4 of the intact healthy rabbits of skin for use, its spinal column both sides, back were cut unhairing area left and right sides Ge Yue 3cm * 3cm by hair in preceding 24 hours in examination.Get during test and tried to be applied to a side skin of unhairing surface on two layers of gauze that thing 0.2cm is applied to 2.5cm * 2.5cm, oilpaper covers, immobilization with adhesive tape.Opposite side skin is blank.Seal after 4 hours, dismantle and clean with warm water and remove the residual thing that tried, spreader portion dermoreaction and scoring are observed in after removal is tried thing 1,24 and 48 hour.
Five, experimental result: laboratory animal skin irritation reaction integrated value is 0, and the anti-integration of reference examples skin irritation is 0, does not see other poisoning sign.Judge that according to skin irritation reaction standards of grading in " disinfection technology standard " this medicinal liquid is to rabbit skin nonirritant.
2, eye irritant test
Earlier with 4 of eye healthy rabbits, get 0.1ml and drop in the branch hole conjunctival sac, by animal closed 4 seconds, with normal saline flushing 5 minutes, opposite side was as normal control.Record is given and to be tried behind the thing damage and the recovery situation of 4 days, 7 days tame lagophthalmos conjunctivas, iris and corneas 6,24,48 hours.In experimental period, laboratory animal contamination back is observed scoring and is 0, and does not see other poisoning sign.
According to eye irritant test evaluation of result standard determination in " disinfection technology standard ", this medicinal liquid is to tame lagophthalmos conjunctiva nonirritant.
3, vaginal mucomembranous irritant test
The experimental animal quarantine was selected 18 healthy rats for use after 3 days, was divided into 3 groups at random, and every group each 6, be respectively blank, the excipient contrast is tried the thing group.The blank group is not handled; The excipient matched group soaks with sterile saline with suitably big or small sterilization cotton sliver and contacts 4 hours with vaginal mucosa, puts to death animal after 24 hours.Take out local vagina tissue, observe the pathological changes situation.
Judge that according to " disinfection technology standard " medial vagina mucomembranous irritant test evaluation criterion this medicinal liquid is to rat vagina mucosa nonirritant.
4, acute oral toxicity test
Select 20 of healthy adult mices, body weight 18-22 gram, female, hero half and half, the dosage design is female to be 6000mg/kg BW, male is 6000mg/kg BW, irritates stomach by 0.1ml/10g BW per os and is tried thing.Irritate the preceding animal fasting of stomach 6 hours, freely drink water.Give normal diet after irritating stomach, observed for two weeks, record poisoning sign and death condition.
Experimental session animal dead situation:
| Dosage (mg/kg BW) | Sex | Number of animals (only) | Dead animal number (only) | Mortality rate (%) |
| ????6000 | Female | ????10 | ????0 | ????0 |
| ????6000 | Male | ????10 | ????0 | ????0 |
In 14 days observation period, animal does not have obvious poisoning sign, does not have death, and postmortem is no abnormal.
Female mice per os LD50 is greater than 5000mg/kg BW.
Male mice per os LD50 is greater than 5000mg/kg BW.
Judge the nontoxic level in this true border of medicinal liquid per os toxicity according to acute toxicity grading criteria in " disinfection technology standard ".
Claims (2)
1, a kind of control virus drugs and preparation method, it has to human papilloma virus (HPV) (AC) and intractable Dermatology poison, the superpower lethal effect of pathogenic bacteria, and diseases prevention, the positive effect of curing the disease does not contain chemical constituent, human body is had no side effect, it comprises with the Fructus Crataegi pit, and Herba Houttuyniae, Herba portulacae, Flos Rosae Rugosae extract and concentrate stock solution by than combining, and its preparation process is: select respectively, flushing with clean water is clean.(Fructus Crataegi pit need pulverization process) then with raw material and water by 1: 1-1: 5 weight ratio is mixed, after soaking 4-10 hour, the raw material that soaks is carried out dry distilling to be extracted, temperature is at 95 ℃-100 ℃, to collect rough liquid, rough liquid is carried out the secondary dry distilling, temperature is 105 ℃-110 ℃, get refined liquid, refined liquid is carried out distillation extraction, 105 ℃-110 ℃ of temperature to be collecting stock solution, the stock solution collected must be concentrated stock solution through concentration extraction preserve stand-byly, form by different proportionings (%) collecting stand-by concentrated stock solution:
Prescription one:
The Fructus Crataegi pit concentrates stock solution 15-50%
Herba Houttuyniae concentrates stock solution 20-50%
Flos Rosae Rugosae extract 0.1-0.5%
Distilled water surplus
Prescription two:
The Fructus Crataegi pit concentrates stock solution 10-25%
Herba portulacae concentrates stock solution 15-40%
Flos Rosae Rugosae extract 0.1-0.3%
Distilled water surplus
2, by right 1 described a kind of control virus drugs and preparation method, it is characterized in that described by the stock solution than preparation also can be mixed with solution, put on the skin, lotion, spray, be used for human body skin (comprising mucosa) health hygienic disinfecting, antimicrobial product, or can also add the pure water of percentage by weight 10-80% at different purposes, be mixed with the strong disinfecting, the sterile products that are used for environment, the articles for daily use, medicated clothing and washing usefulness.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2004100000328A CN1555847A (en) | 2004-01-05 | 2004-01-05 | Medicne for preventing and treating virus and its preparaton method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2004100000328A CN1555847A (en) | 2004-01-05 | 2004-01-05 | Medicne for preventing and treating virus and its preparaton method |
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| Publication Number | Publication Date |
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| CN1555847A true CN1555847A (en) | 2004-12-22 |
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| CNA2004100000328A Pending CN1555847A (en) | 2004-01-05 | 2004-01-05 | Medicne for preventing and treating virus and its preparaton method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101461385A (en) * | 2007-12-20 | 2009-06-24 | 天津仁怡生物工程技术有限公司 | Bacteriostat of gram positive bacteria and gram negative bacteria and use thereof |
| CN101461558B (en) * | 2007-12-20 | 2014-05-07 | 天津仁怡生物工程技术有限公司 | Aspergillus bacteriostatic agent and use thereof |
| CN114680141A (en) * | 2020-12-30 | 2022-07-01 | 山东步长神州制药有限公司 | Use of a natural composition as a disinfectant in blocking the transmission of viruses through packaging surfaces |
-
2004
- 2004-01-05 CN CNA2004100000328A patent/CN1555847A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101461385A (en) * | 2007-12-20 | 2009-06-24 | 天津仁怡生物工程技术有限公司 | Bacteriostat of gram positive bacteria and gram negative bacteria and use thereof |
| CN101461558B (en) * | 2007-12-20 | 2014-05-07 | 天津仁怡生物工程技术有限公司 | Aspergillus bacteriostatic agent and use thereof |
| CN101461385B (en) * | 2007-12-20 | 2014-11-05 | 天津仁怡生物工程技术有限公司 | Bacteriostat of gram positive bacteria and gram negative bacteria and use thereof |
| CN114680141A (en) * | 2020-12-30 | 2022-07-01 | 山东步长神州制药有限公司 | Use of a natural composition as a disinfectant in blocking the transmission of viruses through packaging surfaces |
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